<p><strong>WASHINGTON-Today, May 9, the President’s Task Force on Environmental Health Risks and Safety Risks to Children is publishing the <a href="https://ptfcehs.niehs.nih.gov/features/featured-activity/task-force-reports-progress-federal-lead-action-plan">Progress Report on the Federal Lead Action Plan</a>, a comprehensive update on the government’s progress since 2018 toward reducing childhood lead exposures. The U.S. Department of Housing and Urban Development (HUD), the U.S. Environmental Protection Agency (EPA), and the U.S. Department of Health and Human Services (HHS), as co-leading members of the Task Force’s Lead Exposures Subcommittee, are leading aggressive actions to combat lead exposure.</strong></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/US_Environmental_Protection_Agency_US_Environmental_Protection_Agency_press_release_29a82ee333.jpg" alt="US Environmental Protection Agency: US Environmental Protection Agency press release."/></p>
<p><em>“We’ve made excellent progress toward protecting children from the risks of lead exposure, advancing President Biden’s commitment to environmental justice and protections for all communities,”</em> <strong>said EPA Deputy Administrator Janet McCabe</strong>. <em>“The federal family has taken meaningful steps that will reduce lead exposure, and we are united in our commitment to improve children’s health and to ensure that populations overburdened with pollution have the opportunity to lead healthier lives.”</em></p>
<blockquote>
<p><em>“Children are our future. We must ensure that they have safe places to learn and grow. This progress report outlines the steps we are taking to ensure that healthier future by reducing childhood exposure to lead and shows the Biden-Harris commitment to environmental justice and health equity for all,”</em> <strong>said Assistant Secretary for Health Admiral Rachel Levine.</strong></p>
</blockquote>
<p><em>&quot;Protecting the health of vulnerable populations, especially children and families with limited resources, is paramount. Our Task Force&#39;s progress in implementing the Action Plan reflects the Biden-Harris administration&#39;s shared commitment to investing resources in lead safety programs,&quot;</em> <strong>said HUD Acting Secretary Adrianne Todman</strong>. <em>&quot;The individual programs to implement Justice40 and additional administration initiatives are complemented by the many interagency activities described in the progress report.&quot;</em></p>
<p>The <a href="https://ptfcehs.niehs.nih.gov/sites/niehs-ptfceh/files/resources/lead_action_plan_508.pdf"><strong>2018 Federal Lead Action Plan</strong></a> was released with a clear vision: to reduce childhood exposure to lead and its harmful effects. Since then, the federal government has been working to implement strategies outlined in the plan, and leveraging partnerships with states, Tribes, local communities, business, and caregivers to achieve this shared goal.</p>
<p>The progress report summarizes the significant strides made toward reducing lead exposure and improving children’s health through landmark initiatives including:</p>
<ul>
<li>Reducing lead in drinking water, land, air, food, housing, and consumer products,</li>
<li>Improving childhood lead poisoning testing to improve children’s health outcomes,</li>
<li>Enhancing lead hazard communication with partners and the public with streamlined messaging,</li>
<li>Supporting critical research that informs efforts to reduce lead exposures and health risks, and much more.</li>
</ul>
<p>The President’s Task Force is the focal point for the federal government to scope, plan, and act together for the betterment of children’s environmental health and safety. The Task Force engages <a href="https://ptfcehs.niehs.nih.gov/about"><strong>multiple government departments, agencies, and other federal partners</strong></a> to coordinate efforts to address the array of environmental and social stressors that threaten the health of children, with particular focus on areas including lead exposures, asthma disparities, chemical exposures, climate change, emergencies, and disasters. These efforts have complemented the <a href="https://www.whitehouse.gov/briefing-room/statements-releases/2021/12/16/fact-sheet-the-biden-harris-lead-pipe-and-paint-action-plan/"><strong>Biden-Harris Administration’s Lead Pipe and Paint Action Plan</strong></a>, which laid out over 15 new commitments from more than 10 federal agencies to make sure that the federal government marshals every resource and every tool it can to make rapid progress towards ensuring a lead-free future. These efforts have also complemented the President’s <a href="https://www.whitehouse.gov/environmentaljustice/justice40/"><strong>Justice40 Initiative</strong></a>, which set a goal that 40 percent of the overall benefits of certain federal investments flow to disadvantaged communities that are marginalized by underinvestment and overburdened by pollution.</p>
<p>Read the <a href="https://ptfcehs.niehs.nih.gov/features/featured-activity/task-force-reports-progress-federal-lead-action-plan"><strong>Progress Report on the Federal Lead Action Plan</strong></a>.</p>
<p>Learn more about <a href="https://ptfcehs.niehs.nih.gov/"><strong>The President’s Task Force on Environmental Health Risks and Safety Risks to Children</strong></a>.</p>
<p>Join the Task Force <a href="https://public.govdelivery.com/accounts/USNIHNIEHS/signup/31753"><strong>email list</strong></a></p>


Biden-Harris Administration Reports Significant Progress Toward Protecting Children from Lead Poisoning

<p><strong>For the first time, thorium nuclei have now been successfully transferred from one state to another using a laser – but there has already been speculation for decades about the technical possibilities that would arise if this feat were one day possible. Expectations are high: probably the best-known idea is the nuclear clock, but precision measurements based on the thorium transition could open up new possibilities in completely different areas of research.</strong></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/TU_Wien_Nuclear_Clocks_and_the_Fundamental_Constants_of_Nature_The_nuclear_clock_a_spectacular_application_made_possible_by_the_discovery_of_the_thorium_transition_cbfb93c6fb.jpg" alt="TU Wien: The nuclear clock: a spectacular application, made possible by the discovery of the thorium transition."/></p>
<h4><strong>Time measurement</strong></h4>
<p>The most accurate time measuring devices today are atomic clocks – they have even changed the definition of our units of time. Today, the second is defined as the length of time corresponding to a very specific number of oscillations of the light that must be shone on a caesium atom in order to switch its electrons from one state to another.</p>
<p>Similar to the pendulum of a pendulum clock, the light oscillation of the caesium atoms plays the role of the timer that provides the regular ticking for the most accurate time measurement possible. Today, atomic clocks are used, for example, for the coordination of satellites, they enable the high accuracy of GPS signals and they also play a role in telecommunications.</p>
<p>Instead of cesium atoms, however, thorium atomic nuclei can now also be used for keeping time. Only when the thorium nuclei are irradiated with a laser beam of exactly the right frequency do they change their state. If the laser changes its frequency slightly (e.g. due to external interference), this immediately results in a change of the response of the thorium nuclei. The combination of laser and thorium nuclei therefore makes it possible to keep the laser frequency extremely stable and ensures that the laser frequency does not drift away.</p>
<p>Because atomic nuclei are much smaller than atoms and much less sensitive to electromagnetic perturbations, atomic nuclei can achieve much higher precision than atoms when it comes to measuring time.</p>
<h4><strong>Everything gets better with better clocks</strong></h4>
<p>With better time measurement, other physical quantities can also be measured more accurately. This is a well-known phenomenon: in nautical navigation, for example, people have struggled for a long time with the problem that although it is easy to determine the latitude based on the position of the sun, an accurate clock is required to calculate the longitude correctly. Better time measurement often makes other measurements possible.</p>
<p>For example, Einstein&#39;s theory of relativity states that time does not pass in the same way everywhere: the flow of time depends on the gravitational field. In this way, an extremely precise clock could therefore be used to accurately measure the Earth&#39;s gravitational field – with many possible applications ranging from the search for mineral resources to research into plate tectonics and earthquake prediction.</p>
<p>Great hopes are also pinned on the possibility that new, better clocks could clarify previously unsolved fundamental questions of physics: If it is possible to measure the constants of nature much more accurately than before, then it would also be possible to test the theory that these natural constants may not be perfectly constant at all. Perhaps they change over time? Research into dark matter is also hoping to gain new insights through even more precise measurements.</p>
<p>It is not always possible to get closer to the fundamental laws of nature just by looking at the smallest particles in a particle accelerator or by looking at the most distant regions of space. Sometimes you just need greater precision – and this is where the newly discovered thorium transition and all its potential applications should help in the coming years and decades.</p>
<h4><strong>Back to the main article:</strong></h4>
<ul>
<li><a href="https://gcms.labrulez.com/article/4273"><strong>Atomic Nucleus Excited with Laser: A Breakthrough after Decades</strong></a></li>
</ul>


Nuclear Clocks and the Fundamental Constants of Nature

<p><strong>Physicists have been hoping for this moment for a long time: for many years, scientists all around the world have been searching for a very specific state of thorium atomic nuclei that promises revolutionary technological applications. It could be used, for example, to build an nuclear clock that could measure time more precisely than the best atomic clocks available today. It could also be used to answer completely new fundamental questions in physics - for example, the question of whether the constants of nature are actually constant or whether they change in space and time.</strong></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/TU_Wien_Oliver_Diekmann_Atomic_Nucleus_Excited_with_Laser_A_Breakthrough_after_Decades_A_laser_beam_changes_the_state_of_thorium_nucleui_which_are_embedded_in_a_crystal_940b6404dc.jpg" alt="TU Wien / Oliver Diekmann: A laser beam changes the state of thorium nuclei, which are embedded in a crystal."/></p>
<p>Now this hope has come true: the long-sought thorium transition has been found, its energy is now known exactly. For the first time, it has been possible to use a laser to transfer an atomic nucleus into a state of higher energy and then precisely track its return to its original state. This makes it possible to combine two areas of physics that previously had little to do with each other: classical quantum physics and nuclear physics. A crucial prerequisite for this success was the development of special thorium-containing crystals. A research team led by Prof. Thorsten Schumm from TU Wien (Vienna) has now published this success together with a team from the National Metrology Institute Braunschweig (PTB) in the journal &quot;Physical Review Letters&quot;.</p>
<blockquote>
<p><strong>The &quot;thorium transition&quot;, which physicists have been looking for for decades, has now been excited for the first time with lasers. This paves the way for revolutionary high precision technologies, including nuclear clocks.</strong></p>
</blockquote>
<h4><strong>Switching quantum states</strong></h4>
<p>Manipulating atoms or molecules with lasers is commonplace today: if the wavelength of the laser is chosen exactly right, atoms or molecules can be switched from one state to another. In this way, the energies of atoms or molecules can be measured very precisely. Many precision measurement techniques are based on this, such as today&#39;s atomic clocks, but also chemical analysis methods. Lasers are also often used in quantum computers to store information in atoms or molecules.</p>
<p>For a long time, however, it seemed impossible to apply these techniques to atomic nuclei. <em>&quot;Atomic nuclei can also switch between different quantum states. However, it usually takes much more energy to change an atomic nucleus from one state to another – at least a thousand times the energy of electrons in an atom or a molecule,&quot;</em> says Thorsten Schumm. <em>&quot;This is why normally atomic nuclei cannot be manipulated with lasers. The energy of the photons is simply not enough.&quot;</em></p>
<p>This is unfortunate, because atomic nuclei are actually the perfect quantum objects for precision measurements: They are much smaller than atoms and molecules and are therefore much less susceptible to external disturbances, such as electromagnetic fields. In principle, they would therefore allow measurements with unprecedented accuracy.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/TU_Wien_Foto_Wilke_Atomic_Nucleus_Excited_with_Laser_A_Breakthrough_after_Decades_Thorsten_Schumm_with_a_crystal_containing_thorium_03f3d62c0f.jpg" alt="TU Wien / Foto Wilke: Thorsten Schumm with a crystal containing thorium."/></p>
<h4><strong>The needle in the haystack</strong></h4>
<p>Since the 1970s, there has been speculation that there might be a special atomic nucleus which, unlike other nuclei, could perhaps be manipulated with a laser, namely thorium-229. This nucleus has two very closely adjacent energy states – so closely adjacent that a laser should in principle be sufficient to change the state of the atomic nucleus.</p>
<p>For a long time, however, there was only indirect evidence of the existence of this transition. <em>&quot;The problem is that you have to know the energy of the transition extremely precisely in order to be able to induce the transition with a laser beam,&quot;</em> says Thorsten Schumm. <em>&quot;Knowing the energy of this transition to within one electron volt is of little use, if you have to hit the right energy with a precision of one millionth of an electron volt in order to detect the transition.”</em> It is like looking for a needle in a haystack – or trying to find a small treasure chest buried on a kilometer-long island.</p>
<h4><strong>The thorium crystal trick</strong></h4>
<p>Some research groups have tried to study thorium nuclei by holding them individually in place in electromagnetic traps. However, Thorsten Schumm and his team chose a completely different technique. <em>&quot;We developed crystals in which large numbers of thorium atoms are incorporated,&quot;</em> explains Fabian Schaden, who developed the crystals in Vienna and measured them together with the PTB team. <em>&quot;Although this is technically quite complex, it has the advantage that we can not only study individual thorium nuclei in this way but can hit approximately ten to the power of seventeen thorium nuclei simultaneously with the laser – about a million times more than there are stars in our galaxy.&quot;</em> The large number of thorium nuclei amplifies the effect, shortens the required measurement time and increases the probability of actually finding the energy transition.</p>
<p>On November 21, 2023, the team was finally successful: the correct energy of the thorium transition was hit exactly, the thorium nuclei delivered a clear signal for the first time. The laser beam had actually switched their state. After careful examination and evaluation of the data, the result has now been published.</p>
<p><em>&quot;For us, this is a dream coming true,&quot;</em> says Thorsten Schumm. Since 2009, Schumm had focused his research entirely on the search for the thorium transition. His group as well as competing teams from all over the world have repeatedly achieved important partial successes in recent years. <em>&quot;Of course we are delighted that we are now the ones who can present the crucial breakthrough: The first targeted laser excitation of an atomic nucleus,&quot;</em> says Schumm.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/TU_Wien_PTB_Atomic_Nucleus_Excited_with_Laser_A_Breakthrough_after_Decades_PTB_researcher_Johannes_Tiedau_in_the_laser_lab_e7fa06332a.jpg" alt="TU Wien / PTB: PTB-researcher Johannes Tiedau in the laser lab."/></p>
<h4><strong>The dream of the atomic nucleus clock</strong></h4>
<p>This marks the start of a new exciting era of research: now that the team knows how to excite the thorium state, this technology can be used for precision measurements. <em>&quot;From the very beginning, building an atomic clock was an important long-term goal,&quot;</em> says Thorsten Schumm. <em>&quot;Similar to how a pendulum clock uses the swinging of the pendulum as a timer, the oscillation of the light that excites the thorium transition could be used as a timer for a new type of clock that would be significantly more accurate than the best atomic clocks available today.&quot;</em></p>
<p>But it is not just time that could be measured much more precisely in this way than before. For example, the Earth&#39;s gravitational field could be analyzed so precisely that it could provide indications of mineral resources or earthquakes. The measurement method could also be used to get to the bottom of fundamental mysteries of physics: Are the constants of nature really constant? Or can tiny changes perhaps be measured over time? <em>&quot;Our measuring method is just the beginning,&quot;</em> says Thorsten Schumm. <em>&quot;We cannot yet predict what results we will achieve with it. It will certainly be very exciting.&quot;</em></p>


Atomic Nucleus Excited with Laser: A Breakthrough after Decades

<p><strong>Vaping aerosols contain thousands of unknown chemicals and substances not disclosed by manufacturers, including industrial chemicals and caffeine, Johns Hopkins University researchers found.</strong></p>
<p><strong>The study is the first to apply to vaping liquids and aerosols an advanced fingerprinting technique used to identify chemicals in food and wastewater. The results, <a href="https://pubs.acs.org/doi/10.1021/acs.chemrestox.1c00253">just published in the journal <em>Chemical Research in Toxicology</em></a>, suggest people who vape are using a product whose risks have yet to be fully determined and could be exposing themselves to chemicals with adverse health effects.</strong></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Johns_Hopkins_University_WILL_KIRK_JOHNS_HOPKINS_RESEARCHERS_FIND_THOUSANDS_OF_UNKNOWN_CHEMICALS_IN_ELECTRONIC_CIGARETTES_9b00c7b9b3.jpg" alt="Johns Hopkins University / Will Kirk: Johns Hopkins Researchers Find Thousands of Unknown Chemicals in Electronic Cigarettes."/></p>
<p><em>&quot;Existing research that compared e-cigarettes with normal cigarettes found that cigarette contaminants are much lower in e-cigarettes. The problem is that e-cigarette aerosols contain other completely uncharacterized chemicals that might have health risks that we don&#39;t yet know about,&quot;</em> said senior author <a href="https://engineering.jhu.edu/ehe/faculty/carsten-prasse/"><strong>Carsten Prasse</strong></a>, an assistant professor of environmental health and engineering at the <a href="https://engineering.jhu.edu/"><strong>Whiting School of Engineering</strong></a> and the <a href="https://publichealth.jhu.edu/"><strong>Bloomberg School of Public Health</strong></a>. <em>&quot;More and more young people are using these e-cigarettes and they need to know what they&#39;re being exposed to.&quot;</em></p>
<p>Previous studies of e-cigarettes have looked specifically for evidence of the hazardous chemicals found in traditional cigarettes. But here the researchers performed a nontargeted analysis to explore the full range of chemicals both in the vaping liquid and the aerosols.</p>
<p>Prasse and his team were the first researchers to test vape samples with chromatography/high-resolution mass spectrometry, a chemical fingerprinting technique more commonly used to identify organic compounds in wastewater, food, and blood. Although it&#39;s possible to buy vaping products in hundreds of flavors, for consistency they tested only tobacco-flavored liquids sold by four popular brands—Mi-Salt, Vuse, Juul, and Blu. They found thousands of unknown chemicals in the liquid, and the number of compounds increased significantly in the aerosol. Furthermore, they detected condensed hydrocarbon-like compounds, typically associated with combustion, which manufacturers say is not happening during vaping. In traditional cigarettes, the condensed hydrocarbons generated during combustion are toxic.</p>
<blockquote>
<h4>&quot;I HAVE A PROBLEM WITH HOW VAPING IS BEING MARKETED AS MORE HEALTHY THAN SMOKING CIGARETTES. IN MY OPINION WE ARE JUST NOT AT THE POINT WHEN WE CAN REALLY SAY THAT.&quot;</h4>
</blockquote>
<blockquote>
<p>Carsten Prasse</p>
<h6>Assistant professor, School of Engineering</h6>
</blockquote>
<p><em>&quot;One of the main ways electronic cigarettes have been marketed is that they operate at temperatures below combustion, which would make them safer than traditional smoking,&quot;</em> said lead author Mina Tehrani, a postdoctoral fellow in the School of Public Health. <em>&quot;Our study shows that this novel fingerprinting approach can be applied to assess whether combustion-like processes are going on.&quot;</em></p>
<p>The team found nearly 2,000 chemicals, the vast majority of which are unidentified. Of those the team could identify, six substances were potentially harmful, including three chemicals never previously found in e-cigarettes. Tehrani was particularly surprised to find the stimulant caffeine in two of the four products. Caffeine has previously been detected in e-cigarettes but only in the caffeine-oriented flavors like coffee and chocolate.</p>
<p><em>&quot;That might be giving smokers an extra kick that is not disclosed,&quot;</em> she said. <em>&quot;We wonder if they are adding it intentionally.&quot;</em></p>
<p>Besides caffeine, the team found three industrial chemicals, a pesticide, and two flavorings linked with possible toxic effects and respiratory irritation.</p>
<p>Prasse said he became interested in studying vaping products after his cousin, a former smoker, started vaping, insisting it was healthy. He plans to send that cousin this paper.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Johns_Hopkins_University_WILL_KIRK_JOHNS_HOPKINS_RESEARCHERS_FIND_THOUSANDS_OF_UNKNOWN_CHEMICALS_IN_ELECTRONIC_CIGARETTES_1_f38915afda.jpg" alt="Johns Hopkins University / Will Kirk: Johns Hopkins Researchers Find Thousands of Unknown Chemicals in Electronic Cigarettes."/></p>
<p><em>&quot;People just need to know that they&#39;re inhaling a very complex mixture of chemicals when they vape. And for a lot of these compounds we have no idea what they actually are,&quot;</em> Prasse said. <em>&quot;I have a problem with how vaping is being marketed as more healthy than smoking cigarettes. In my opinion we are just not at the point when we can really say that.&quot;</em></p>
<p>Co-author Ana M. Rule, an expert in metals exposures from vaping with the Johns Hopkins Bloomberg School of Public Health, says many young people who vape never smoked—so they aren&#39;t making a healthier choice, only starting out with a risky one.</p>
<p><em>&quot;There are millions of middle school and high school students vaping that would not otherwise think of smoking,&quot;</em> she says. <em>&quot;For them there is no risk reduction, only increased risk.&quot;</em></p>
<p>Authors also include Matthew N. Newmeyer, a postdoctoral fellow at the Johns Hopkins Bloomberg School of Public Health. The work was supported by grants from the National Institute of Environmental Health Sciences, the National Center for Advancing Translational Sciences, and NIH Roadmap for Medical Research.</p>


Johns Hopkins Researchers Find Thousands of Unknown Chemicals in Electronic Cigarettes

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 22nd July 2024? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p>
<blockquote>
<h4>👉 <a href="https://gcms.labrulez.com/library"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></a></h4>
</blockquote>
<blockquote>
<p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p>
</blockquote>
<p>This week we bring to you poster presentations from <a href="https://gcms.labrulez.com/events/568"><strong>ASMS 2024</strong></a> by <strong>LECO</strong>, <strong>Agilent Technologies</strong>, and <strong>Thermo Fisher Scientific</strong>! And as a bonus two application notes from <strong>Shimadzu</strong> and <strong>Thermo Fisher Scientific</strong>.</p>
<blockquote>
<p>💡 <strong>+ 100 ASMS posters and presentations <a href="https://gcms.labrulez.com/library?mainauthorItems=284">available in the LabRulezGCMS library</a></strong> (unique search and filtering)</p>
</blockquote>
<h4><strong>1. LECO: <a href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/Long_Lifetime_Ion_Detector_GC_G_Cx_GC_TOFMS_MS_ASMS_24_LPSS_326_4c9e1fb7a1.pdf">A Novel Long-Lifetime Ion Detector for GC-TOFMS and GCxGC-TOFMS with Sub-Femtogram Detection Limits</a></strong></h4>
<ul>
<li>poster - ASMS 2024</li>
</ul>
<p><strong>Introduction:</strong> Ion detection efficiency and fast response times are critical aspects of the ion detectors used in time-of-flight mass spectrometry (TOFMS). With modern advancements in ionization, ion optics, and ion transfer efficiency, TOFMS systems are capable of generating high ion flux onto the ion detectors. Having an ion detector that is capable of maintaining optimal performance over a long period of time while accepting high amounts of ion flux is a significant challenge in development of TOFMS instrumentation. Improvements in detector life will minimize maintenance costs and improve TOFMS user experience. A novel long-lifetime ion detector was developed in partnership with El Mul Technologies for use in LECO’s Pegasus® BTX GC and GCxGCTOFMS. The system was thoroughly evaluated for sensitivity and robustness, including longevity of the detector.</p>
<p><strong>Conclusions:</strong> The Pegasus BTX GC(GCxGC)-TOFMS with a novel Long-Lifetime Ion Detector has demonstrated the following performance characteristics:</p>
<ul>
<li>Sub-2 fg IDL for GC-TOFMS and Sub-fg IDL for GCxGC-TOFMS </li>
<li>Linear dynamic range of 5 orders of magnitude in GC-TOFMS and 4 orders of magnitude in GCxGC-TOFMS</li>
<li>Robust operation: the detector bias remains consistent and BTX peak intensity remains consistent over long periods of time, even with large numbers of samples acquired and significant amounts of charge accumulation on the detector.</li>
</ul>
<h4><strong>2. Thermo Fisher Scientific: <a href="https://gcms.cz/labrulez-bucket-strapi-h3hsga3/po_142_utilizing_hydrogen_pesticides_food_gc_ms_po142_asms2024_en_7ed0951b93.pdf">Utilizing hydrogen carrier gas for sensitive analysis of pesticides in food using gas chromatography mass spectrometry</a></strong></h4>
<ul>
<li>poster - ASMS 2024</li>
</ul>
<h5><strong>Abstract</strong></h5>
<p><strong>Purpose:</strong> To demonstrate the performance of the Thermo Scientifc HeSaverH2Safer kit for iConnect split-splitless (SSL) injection module for trace analysis of pesticides using H2 as a carrier gas as a safe and sustainable solution for laboratory operations.</p>
<p><strong>Methods:</strong> In this study, hydrogen was used as a carrier gas for GC-MS/MS analysis of trace levels of pesticides in food. The GC was fitted with a new hydrogen safer split/splitless injector, with chromatographic separation performed on a TG-5 SIL MS(30 m × 0.25 mm, 0.25 μm) capillary GC column. The chromatographic conditions applied ensured critical pair separation was achieved. The GC-MS/MS system was equipped.</p>
<h5><strong>Conclusions</strong></h5>
<ul>
<li>The use of the HeSaver-H2Safer technology allows for a safe and compliant use of hydrogen as an alternative carrier gas in GC/GC-MS applications without the need to install a hydrogen sensor and removes any risk of unwanted reactions with the sample in the hot SSL injector.</li>
<li>When used with hydrogen, the limited carrier gas consumption offered by the HeSaverH2Safer mode permits a very controlled system demand for hydrogen, making this solution ideal for laboratories working with hydrogen generators.</li>
<li>Migrating the GC-MS/MS method from helium to hydrogen requires an adaptation of method parameters to address (i.e., retention time shift and different fragmentation patterns).</li>
<li>97% of pesticides in baby food and 98% in honey showed a linear response in the concentration range 0.005–0.500 mg/kg and the relative standard deviation for N=5 repeats of each sample type at 0.01 mg/kg was equal or lower than 10% for 98% of the evaluated compounds with an advanced electron ionization (AEI) source to increase sensitivity for analyte detection. Quantification and assessment of critical regulatory requirements, such as linearity and sensitivity, were performed in a single software.</li>
</ul>
<h4><strong>3. Agilent Technologies: <a href="https://gcms.cz/labrulez-bucket-strapi-h3hsga3/po_142_utilizing_hydrogen_pesticides_food_gc_ms_po142_asms2024_en_7ed0951b93.pdf">Analyzing Nitrosamines with Hydrogen Carrier Gas: GC/MS/MS Analysis of Nitrosamines in Sartan Drugs</a></strong></h4>
<ul>
<li>Poster Reprint - ASMS 2024</li>
</ul>
<p><strong>Introduction:</strong> The limited availability of helium has been a concern, leading to a growing interest in switching to alternative carrier gases like hydrogen. Hydrogen offers several advantages over helium1 , including faster run times and improved chromatographic resolution. Helium is commonly used as a carrier gas for analyzing nitrosamine impurities in pharmaceuticals. However, there are concerns that nitrosamines may react with hydrogen, forming unwanted byproducts. To ensure that using hydrogen as a carrier gas does not impact spectral quality, we evaluated its suitability for analyzing eight impurities:</p>
<ul>
<li>N-nitrosodimethylamine (NDMA),</li>
<li>N-nitrosomethylethylamine (NMEA),</li>
<li>N-nitrosodiethylamine (NDEA),</li>
<li>N-nitroso-ethylisopropylamine (NEIPA),</li>
<li>N-nitrosodiisopropylamine (NDIPA),</li>
<li>N-Nitrosodipropylamine (NDPA),</li>
<li>N-nitrosodi-n-butylamine (NDBA),</li>
<li>N-Nitrosopiperidine (NPIP).</li>
</ul>
<p>Hydrogen carrier gas was used with the 7000E and 7010 Series GC/TQ systems equipped with the HydroInert and HES ion sources respectively, assessing spectral quality, linearity, repeatability, recovery, and compliance with nitrosamine analysis regulations.</p>
<p>MassHunter 13 software suite provided the tools for data acquisition and processing to be performed under a unified compliance environment. OpenLab Electronic Content Management (ECM) XT includes native tools to facilitate compliance, including the ability to create users with affiliated permissions, the generation of audit trails, and remote data storage.</p>
<p><strong>Conclusions:</strong></p>
<ul>
<li>The 7000E and 7010 Series GC/TQ systems equipped with the HydroInert and HES, respectively, exhibited exceptional performance in determining eight nitrosamine drug impurities in sartan drug products and substances using hydrogen carrier gas.</li>
<li>The method was validated at 30 ppb with acceptable recovery and long-term repeatability. </li>
<li>The 7010 Series GC/TQ system enabled a smooth switch between helium and hydrogen carrier gas without compromising the performance of the methods. </li>
<li>Both the HydroInert and the HES sources facilitated achieving the necessary detection limits for the tested impurities.</li>
</ul>
<h4><strong>4. Agilent Technologies: <a href="https://gcms.cz/labrulez-bucket-strapi-h3hsga3/po_142_utilizing_hydrogen_pesticides_food_gc_ms_po142_asms2024_en_7ed0951b93.pdf">Analysis of Essential Oils Using a Comprehensive GCxGC with a Reverse Flow Modulator Combined with High Resolution GC/MS</a></strong></h4>
<ul>
<li>Poster Reprint - ASMS 2024</li>
</ul>
<p><strong>Introduction:</strong> Essential oils are typically analyzed to determine their chemical composition contributing to flavor and quality as well as to evaluate their authenticity and identify adulterants. Essential oils are often complex samples with high number of volatile and semi-volatile components that include many isomers with highly similar spectra and close Retention Indices (RIs) when separated on a single column. Hence, a comprehensive GCxGC approach is preferable to achieve an appropriate chromatographic separation for this sample matrix. In this study we used comprehensive GCxGC coupled to a high-resolution accurate mass GC/MS to identify the essential oil  components. Here we also investigate approaches for comparison of the complex GCxGC essential oil data.</p>
<p><strong>Conclusions:</strong></p>
<ul>
<li>Several comprehensive GCxGC configurations and method using the high-resolution GC/Q-TOF and RFM were developed and optimized using a diesel sample. </li>
<li>Essential oils were analyzed using the optimized GCxGC approach, and the workflows for compound identification and statistical analysis were evaluated.</li>
</ul>
<h4><strong>5. Shimadzu: <a href="https://gcms.cz/labrulez-bucket-strapi-h3hsga3/an_01_00746_en_e14cf49b7b.pdf">Greenhouse Gas Analyzer</a></strong></h4>
<ul>
<li>Application</li>
</ul>
<p><strong>User Benefits:</strong></p>
<ul>
<li>Simultaneously measures the 3 main greenhouse gases: CH₄, CO₂, and N₂O.</li>
<li>Offers short analysis cycle times and is equipped with an AOC-6000 Plus syringe injection system to analyze large numbers of samples.</li>
<li>Uses nitrogen as a carrier gas for lower running costs.</li>
</ul>
<p><strong>Introduction:</strong> Greenhouse gases are a major cause of climate change, and carbon dioxide, (CO₂), methane (CH₄), and nitrous oxide (N₂O) are considered the 3 primary greenhouse gases. Although CO₂ accounts for the majority of greenhouse gas emissions followed by CH₄, reducing CH₄ emissions is considered important because CH₄ has a warming effect that is more than twenty times greater than CO₂. At the United Nations Climate Change Conference (COP26) in November 2021, over 100 countries joined the Global Methane Pledge, which pledges by 2030 to reduce global CH₄ emissions by 30 % compared to 2020 levels. The Greenhouse Gas Analyzer is a gas chromatography system that has been developed by Shimadzu in collaboration with the National Agriculture and Food Research Organization (NARO) (Fig. 1). Measuring levels of CH₄, CO₂, and N₂O simultaneously in a single sample is difficult, but the Greenhouse Gas Analyzer has been designed to do this simultaneously, which reduces analytical errors and improves the sampling speed, giving researchers a valuable tool in reducing greenhouse gas emissions.</p>
<p>This Application News describes using the Greenhouse Gas Analyzer to simultaneously measure CO₂, CH₄, and N₂O levels.</p>
<p><strong>Conclusion:</strong> The Greenhouse Gas Analyzer can simultaneously measure 3 greenhouse gases in atmospheric air in a single analysis. Each analysis by the Greenhouse Gas Analyzer is performed in 8 minutes with an analysis cycle time of 10 minutes.</p>
<h4><strong>6. Thermo Fisher Scientific: <a href="https://gcms.cz/labrulez-bucket-strapi-h3hsga3/an_002695_gc_triplus_rsh_smart_sample_prep_environ_an002695_na_en_77a5aa2300.pdf">An automated approach for the analysis of VOCs in drinking and surface water by using the TriPlus RSH SMART VOC Sample Prep Station</a></strong></h4>
<ul>
<li>Application - Environmental</li>
</ul>
<p><strong>Goal:</strong> The aim of this study is to demonstrate the suitability of the Thermo Scientific™ TriPlus™ RSH SMART VOC Sample Prep Station for the analysis of volatile organic compounds (VOCs) in drinking and surface water by using a fully automated sample preparation workflow.</p>
<p><strong>Keywords:</strong> Automated sample preparation, TriPlus RSH SMART Sample Prep Station, volatile organic compounds, VOCs, drinking water, surface water, gas chromatography, TRACE 1610 GC, single quadrupole mass spectrometry, ISQ 7610 GC-MS.</p>
<p><strong>Conclusions:</strong> The results of these experiments demonstrate that the automated sample preparation capability of the TriPlus RSH SMART VOC Sample Prep Station coupled to the ISQ 7610 GC-MS system provides an ideal solution for water testing laboratories looking to improve productivity and deliver confident results.</p>
<ul>
<li>Static headspace is a convenient solventless extraction technique for volatiles in water with almost no sample preparation required. </li>
<li>Unattended operations of up to 210 samples can be achieved with the automated calibration dilution and ISTD addition workflows.</li>
<li>The automated addition of fresh reagent just before the incubation increases the stability of ISTD/surrogates mix, therefore improving the accuracy of the quantitation of target analytes during data reprocessing.</li>
<li>The TriPlus RSH SMART VOC Sample Prep Station ensures increased sample integrity for highly reliable quantitative analysis, and reduced errors or possible cross-contaminations, maximizing the productivity of the laboratory. Additionally, it allows saving valuable analyst time and improving safety by limiting the user’s exposure to toxic chemicals. </li>
<li>The integrated control for both autosampler and GC-MS in a single CDS ensures a streamlined automated workflow from on-line sample preparation to sequence setup, data acquisition, and reporting. </li>
<li>Suitability of headspace sampling for analysis of VOCs was demonstrated with R2  &gt; 0.990, RRF %RSD &lt; 20%, and calculated amount within 20% of the spiked concentration. </li>
<li>Inter-day reproducibility was demonstrated by running three batches of samples bracketed with QCs. Average absolute peak area %RSD across the entire evaluation period was &lt;20%, the QC calculated amount was within 20% of the expected value, and the calculated recovery was within 70–130%, with the only exception of 1,2-dibromo-3-chloropropane for which the % recovery was 132. </li>
<li>Reliable quantitative analysis was achieved for drinking water samples and surface water samples analyzed in three different batches across six working days. All the sample results were compliant with the thresholds set by the current EU regulation.</li>
</ul>


News from LabRulezGCMS Library - Week 30, 2024

<p><strong>In the 2 weeks from July 29, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p>
<blockquote>
<h4><a href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4>
</blockquote>
<blockquote>
<p><strong>👉 Search and filter in the largest global database</strong>  with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p>
</blockquote>
<h5><strong>1. Markes International: Simplifying sample preparation for GC–MS</strong></h5>
<ul>
<li>Tu, 30.7.2024 12:00 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/4131">Registration</a></li>
</ul>
<p>This webinar addresses the use of an innovative, robust and cost-effective sampling device, the Micro-Chamber/Thermal Extractor, combined with the thermal desorption GCMS.</p>
<h5><strong>2. Agilent Technologies: GC and GC/MS Frequently Asked Questions</strong></h5>
<ul>
<li>Tu, 30.7.2024 17:00 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/3896">Registration</a></li>
</ul>
<p>To help you improve your chromatographic know-how, we’ve compiled a list of some of our most frequently asked questions.</p>
<h5><strong>3. Agilent Technologies: Simplified Measurement of Content Distribution of Pharma Tablets</strong></h5>
<ul>
<li>Tu, 30.7.2024 21:30 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/3905">Registration</a></li>
</ul>
<p>Content distribution of entire pharma tablets can be quickly measured using the component-specific workflow of the LDIR.</p>
<h5><strong>4. Agilent Technologies: Analysis of Per- and Polyfluoroalkyl Substances in Different Media: Produce, Wastewater, and Air</strong></h5>
<ul>
<li>We, 31.7.2024 17:00 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/4134">Registration</a></li>
</ul>
<p>This presentation will summarize analytical methods to determine PFAS concentrations in produce from the vicinity of a fluorochemical plant, wastewater, and air near wastewater treatment plants.</p>
<h5><strong>5. Phenomenex: Solid Phase Extraction Introduction and Theory</strong></h5>
<ul>
<li>Tu, 6.8.2024 19:00 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/4159">Registration</a></li>
</ul>
<p>Understand the benefit of using SPE than other sample preparation techniques.</p>
<h5><strong>6. C&amp;EN/Metrohm: Smart and Actionable: Spectroscopy PAT-Supported Process Operations</strong></h5>
<ul>
<li>We, 7.8.2024 19:00 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/4175">Registration</a></li>
</ul>
<p>How Albemarle Corporation approached the implementation of Spectroscopy PAT to obtain smarter process operations and what you can do to help drive a mindset change in your business.</p>
<h5><strong>7. Agilent Technologies: Advanced GC/MS | GC/HR-MS Based Workflow for Extractable and Leachable Analysis</strong></h5>
<ul>
<li>Th, 8.8.2024 11:30 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/4136">Registration</a></li>
</ul>
<p>Whether you are scouting or conducting a targeted screening, suspect screening, or nontargeted screening, Agilent can help with a wide range of analytical technologies.</p>


Webinars LabRulezGCMS Week 31-32/2024

<p><strong>Although he originally wanted to study mathematics, Tomáš Janoš eventually became an environmental epidemiologist. He completed his doctorate at RECETOX focusing on human biomonitoring, for which he received the Dean’s Award of the MU Faculty of Science. When he was in Spain, analyzing mortality due to heat and cold, he realized that he wanted to devote himself to studying the impact of extreme temperatures on human health. In the interview, he explains the origins of his interest in climate change, how such a topic is communicated to the public, and why he believes it is crucial for scientists in the Czech Republic to focus more on this issue.</strong></p>
<h5><strong>How did you become interested in climate change in your scientific work?</strong></h5>
<p>I was interested in climate change and the impacts of extreme temperatures on human health for most of my doctorate but I found space for this topic only at the very end. I noticed that in southern European countries, research on the impact of temperature on health is advancing, while Central and Eastern Europe is lagging. So, I thought exploring whether high and low temperatures have similar effects here would be interesting. At that time, I contacted colleagues from the Institute for Global Health in Barcelona, who have extensive experience with research on this topic. Then, I went to Spain with Czech data to learn how to process and analyze them. The topic intrigued me during my three months there, so I decided to write my own project and focus more on this direction.</p>
<h5><strong>In October 2023, a study on the relationship between mortality rates and extreme temperatures was published based on your work. Are you still dealing with this topic?</strong></h5>
<p>Yes, in connection with extreme temperatures, I also started to examine ambulance dispatches in the Czech Republic, which have not yet been explored on the national level in Europe. Such research examines different socio-economic groups and locations, which is important because temperatures vary from place to place. We have written a scientific article on this topic, which we hope to publish by the end of the year. Interestingly, not just elderly people, but also small children, teenagers, and young adults are at high risk. I also have a project studying the impact of short-term temperature fluctuations in combination with polluted air, such as smog, on the number of work accidents, especially among outdoor workers. I will be doing research for another two years, again with people from Barcelona, who are trying to create a European-wide database of work accidents, which already includes the Czech Republic, among others.</p>
<h5><strong>Is it difficult to get data for this type of research?</strong></h5>
<p>Data on deaths is obtained through excellent cooperation with the Institute of Health Information and Statistics of the Czech Republic. On the other hand, data on ambulance dispatches are much more difficult to obtain because of their sensitivity. We get them for certain territorial units, ambulance dispatches for example for districts, which is a terribly large territorial unit. If we went lower, we would get to the numbers of one, two dispatches a day, from which it would already be possible to deduce who it was specifically on a smaller territory. Also, not in all countries have data on ambulance dispatches collected and a database is made. Here, the information is again collected by the Institute of Health Information and Statistics of the Czech Republic from insurance companies, so a summary can be made. However, not in all countries does it work so comprehensively.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/RECETOX_In_the_next_years_climate_change_will_affect_everything_says_environmental_epidemiologist_Tomas_Janos_1_53337bc013.jpg" alt="RECETOX: In the next years, climate change will affect everything, says environmental epidemiologist Tomáš Janoš 1."/></p>
<h5><strong>So you work more with a summary of data, how do you find out that the dispatches were related to the temperature?</strong></h5>
<p>In general, attributing something to the weather is extremely difficult, something like that is not often even part of the diagnosis. Then there are epidemiological models that calculate with daily temperature and dispatches, and when they see some fluctuation that cannot be explained by anything else, they attribute it to the temperature. So we just get specific numbers and we do the calculations through models.</p>
<h5><strong>As for extreme temperatures in cities in general, can the aforementioned health risks be systematically prevented?</strong></h5>
<p>Definitely. Mortality studies for example show that in greener cities it is generally cooler by one to two degrees, which can save several lives a year. Furthermore, a network of fountains can be built, where a person can cool down. In Barcelona, for example, they have so-called climate refuges. It is a network of places where people from can hide in case of a heat wave. It’s nothing special, they are usually air-conditioned public places like supermarkets, libraries or museums, for which a map is created. Thanks to it, people find out where they can go in case of need and where they will be accepted. Therefore, it is important to inform the public and communicate the existence of refuges well, especially to populations which are at a higher risk, such as the elderly, and lower socioeconomic groups, for example by distributing leaflets. In Spain, they also created an early warning system, which several days in advance reports how high is the probability that due to high temperatures a certain number of people will die. Although it sounds morbid, it allows public institutions, such as hospitals and rescue services, to prepare for such a risk.</p>
<h5><strong>As for communication with the public, do you cooperate with other organizations or other public actors?</strong></h5>
<p>As an expert, I cooperate externally for example with Klimatická koalice, which is a platform of Czech non-profit organizations dealing with climate protection. One of their recent activities is the education of medical students in the field of climate change and how it can affect human health, because it is completely missing in the curriculum. The idea is that older people, for whom climate change poses the highest risk in terms of health, but at the same time tend to underestimate it the most, could draw information from doctors, who are a trustworthy authority for them.</p>
<h5><strong>And what does such cooperation bring to you as a scientist?</strong></h5>
<p>From my point of view as a scientist, it is often difficult to get the information to the right place where it will have an effect. Organizations like Klimatická koalice, Fakta o klimatu or the Institute for Czech Policy EUROPEUM help me a lot in this. When we published the study, thanks to the fact that I sent the information about it to everyone I knew would be interested in it, several public or media outputs were created. I probably wouldn’t be able to get it into awareness like this myself.</p>
<h5><strong>So do you have to initiate the first dissemination of information yourself?</strong></h5>
<p>Yes, we as scientists are not pushed into popularizing science much. It is usually more our own interest and it is not part of our performance. Communication is important and should be taken care of. In science, we often pat ourselves on the back, what a great article we published, but when you come to ordinary people outside the scientific sphere, they are interested in information, not the impact of the journal. Of course, at the beginning there must be a quality scientific study, but the actual effect should not be forgotten. Another thing is that it is difficult to communicate a complex problem well and convey it in a few sentences. To do it well, you need to educate yourself. But in practice, there is no time to do either.</p>
<h5><strong>What is it like to communicate the topic of climate change from the perspective of science?</strong></h5>
<p>There is definitely interest in the climate among the public, but when you say climate, it acts like a red rag. It evokes in people things that they will not be able to do or something for which others will condemn them. Moreover, I am afraid that over time it will rather worsen. At the same time, I think that people are interested in climate protection and the environment, we are just at it again, that it is necessary to communicate it all better.</p>
<h5><strong>How does the scientific community react to the topic of climate change? Is there interest there too?</strong></h5>
<p>I feel that the interest is primarily abroad so far. The impacts of it probably do not affect the Czech Republic so much yet, but it certainly awaits us. In the next fifty years, climate change will affect everything, including environmental epidemiology. I am dealing with a very limited section of the whole issue, but there are many more aspects. Through new invasive species, it will be necessary to change the way pesticides are used, there will be an increase in the incidence of infectious diseases, floods, cloudbursts, the change will affect air research, food safety or migration. We should not close our eyes to such a complex and difficult to explain problem as climate change. Whole research groups are devoted to it at foreign institutes, so the Czech Republic should not miss the boat.</p>


In the next years, climate change will affect everything, says environmental epidemiologist Tomáš Janoš.

<h3><strong>About us</strong></h3>
<p>Our laboratory is equipped with high-end mass spectrometry instruments, which offers services in field of <strong>PROTEOMICS</strong> and <strong>METABOLOMICS</strong>. All our services are available for everybody from the academic and non-academic areas.</p>
<h5><a href="https://www.biocev.eu/en/services/omics-mass-spectrometry-core-facility.6#core-facility-services"><strong>Our Services:</strong></a></h5>
<ul>
<li><strong>Preparation of samples</strong> for analysis (cells, body fluids, tissues, plants etc.)</li>
<li><strong>Targeted</strong> or <strong>untargeted</strong> <strong>proteomics</strong> and <strong>metabolomics</strong> analysis</li>
<li><strong>Data analysis</strong> and basic statistical evaluation</li>
<li><strong>Consultation</strong> of experimental design and the results</li>
</ul>
<h5><strong>Proteomics:</strong></h5>
<p>We are modern well equipped laboratory with the technical background able to perform most of the currently used <a href="https://www.biocev.eu/en/services/omics-mass-spectrometry-core-facility.6/untargeted-proteomics.24?t=s"><strong>untargeted</strong></a> and <a href="https://www.biocev.eu/en/services/omics-mass-spectrometry-core-facility.6/targeted-proteomics.25?t=s"><strong>targeted</strong></a> proteomic measurements. We provide full proteomics service, including protein isolation from the supplied sample to evaluation and consultation of the measured data. Since 2015, we handle approximately 300 orders per year (roughly 3000 samples). Results based on measurements from our laboratory were used in dozens of publications. To consult your plan, please contact Karel Harant (karel.harant@natur.cuni.cz) or Pavla Talacko (pavel.talacko@natur.cuni.cz).</p>
<h5><strong>Metabolomics:</strong></h5>
<p>As a service, we provide <a href="https://www.biocev.eu/en/services/omics-mass-spectrometry-core-facility.6/targeted-metabolomics.26?t=s"><strong>targeted</strong></a> and <a href="https://www.biocev.eu/en/services/omics-mass-spectrometry-core-facility.6/untargeted-metabolomics.30?t=s"><strong>untargeted</strong></a> analysis of small molecules. Thanks to the combination of equipment for <strong>LC-MS</strong> and <strong>GCxGC-MS</strong>, it is possible to measure a wide range of small molecules. We use several types of <strong>C18</strong> and <strong>HILIC</strong> stationary phase columns on LC. For GC, we have various columns for different types of analytes. Individual measuremnts must always be consulted in advance, an individual approach and method must be chosen for each group of molecules. Please contact Olga Součková (souckoo@natur.cuni.cz) for LC-MS or Petr Žáček (zacek@natur.cuni.cz) for GCxGC-MS.</p>
<blockquote>
<p><strong>All our services are available for everybody from the academic and non-academic areas.</strong></p>
</blockquote>
<blockquote>
<p><strong>Contact us before you start your first experiment: +420 325 873 925!</strong></p>
</blockquote>
<blockquote>
<p><strong>23.7.2024 Waiting time from “sample to result” is approximately 6-8 weeks.</strong></p>
</blockquote>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/BIOCEV_Introducing_BIOCEV_OMICS_Mass_Spectrometry_Core_Facility_cover_image_7cb6de4462.jpg" alt="BIOCEV: BIOCEV OMICS Mass Spectrometry Core Facility"/></p>
<h3><strong>Services</strong></h3>
<ul>
<li>Preparation of samples for analysis</li>
<li>Untargeted and targeted proteomics</li>
<li>Untargeted and targeted metabolomics</li>
<li>Data analysis and basic statistical processing</li>
<li>Consultation of experiment design and measured data</li>
</ul>
<h4><strong>Untargeted proteomics</strong></h4>
<h5><strong>Up to 8000 identified proteins in one injection.</strong></h5>
<p>A basic type of proteomic experiment. Complete lysate is digested with trypsin. The resulting peptides are desalted and separated on a reverse phase column. Due to the low amount of proteins and the high complexity of the sample, liquid chromatography is currently most often used in nanoflow - hundreds of nanoliters per minute. Liquid chromatography is directly connected to the electrospray of the Orbitrap Fusion or Orbitrap Ascend mass spectrometer. The mass spectrometer measures alternately in two modes: MS¹, where peptide masses are measured in the Orbitrap with high resolution and accuracy, and MS², in which peptides selected from the previous MS¹ scan are fragmented. These are measured either again in the Orbitrap or in the ion trap. The ion trap provides lower accuracy and resolution than the Orbitrap, but is faster and more sensitive.</p>
<blockquote>
<p><strong>We offer untargeted proteomics measurement and analysis of post-translational modifications in different types of samples (cells, tissues, body fluids, plant samples, etc.).</strong></p>
</blockquote>
<blockquote>
<p><strong>Our newest service is &quot;Thermal proteome profiling (TPP)&quot; that allows you direct detection of drug-protein interactions in living cells.</strong></p>
</blockquote>
<h5><strong>Examples of analyses:</strong></h5>
<ul>
<li>LFQ (label free quantification)</li>
<li>TMT (tandem mass tags)</li>
<li>TPP (Thermal proteome profiling)</li>
<li>phosphoproteome profiling</li>
<li>pull-down experiments</li>
</ul>
<h5><strong>Tips for sample handling:</strong></h5>
<ul>
<li>do not use trypsin for cell harvesting</li>
<li>inform us about presence of detergent</li>
<li>always keep in mind same protein loading for pull-down experiments (eg. Co-immunoprecipitation)</li>
<li>do not use phosphatase inhibitors for phosphoproteomic experiments</li>
</ul>
<h4><strong>Targeted proteomics</strong></h4>
<h5><strong>Accurate quantification of selected proteins.</strong></h5>
<p>Method aims to validate the results from an untargeted approach. It is performed on a triple quadrupole in SRM mode or using the MRM method on an Orbitrap. It is an an alternative approach to common techniques such as western blot. The advantage of this approach is the possibility to analyze several proteins (dozens) at once during one injection. This eliminates the problem of finding suitable antibodies.</p>
<blockquote>
<p><strong>The targeted proteomics service is always project specific and we offer it after prior meeting with the customer.</strong></p>
</blockquote>
<p>Parallel analysis of peptides labeled with heavy amino acids is essential. These serve as an internal standards.</p>
<p>The amount of proteins that can be targeted in one injection using a triple quadrupole, is strongly dependent on the concentration of the target proteins in the sample. The lower the expression of the target proteins, the less it is possible to analyze them in one injection due to the need for higher loading times. Information of fragmentation properties of targeted peptides is also important. This is usually obtained from an untargeted experiment, which should precede the targeted proteomic analysis. If the protein of interest was not detected during an untargeted experiment, then its targeted analysis is very difficult. However, in some cases fragmentation information can be obtained from publicly available databases.</p>
<h5><strong>Tips for sample handling:</strong></h5>
<ul>
<li>do not use trypsin for cell harvesting</li>
<li>inform us about presence of detergent</li>
<li>always keep in mind same protein loading for pull-down experiments (eg. Co-immunoprecipitation)</li>
<li>do not use phosphatase inhibitors for phosphoproteomic experiments</li>
</ul>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/BIOCEV_Introducing_BIOCEV_OMICS_Mass_Spectrometry_Core_Facility_Targeted_proteomics_1_f0605d8efc.jpg" alt="BIOCEV: Introducing BIOCEV OMICS Mass Spectrometry Core Facility - Targeted proteomics."/></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/BIOCEV_Introducing_BIOCEV_OMICS_Mass_Spectrometry_Core_Facility_Targeted_proteomics_2_f1af260d27.jpg" alt="BIOCEV: Introducing BIOCEV OMICS Mass Spectrometry Core Facility - Targeted proteomics."/></p>
<h4><strong>Untargeted metabolomics</strong></h4>
<p>The goal of untargeted metabolomics is to cover the widest possible spectrum of metabolites present in the sample, their identification, and quantification. The development of this approach was made possible by the recent advances in instrumentation and computing. Our laboratory equipment enables non-targeted analyses by liquid and gas chromatography.</p>
<blockquote>
<p><strong>We offer untargeted analyses of metabolites in various biological matrices and basic statistical evaluation of the data (Figure 2, 3, 4).</strong></p>
</blockquote>
<blockquote>
<p><strong>Our newest service is stable isotope tracing (Figure 1).</strong></p>
</blockquote>
<p>HPLC-MS/MS (Figure 2): Analyzes are performed on Thermo Scientific equipment on an Ultimate 3000 liquid chromatograph coupled to an Orbitrap Fusion mass detector. The measured data are evaluated by the Compound Discoverer software.</p>
<p>GCxGC-MS (Figure 3): Analyzes are performed on a two-dimensional comprehensive chromatograph connected to a Pegasus 4D mass detector. We evaluate the data in ChromaTOF v4.5 software.</p>
<p>The liquid chromatography method covers non-volatile substances, generally polar, soluble in water, and polar organic solvents (methanol, acetonitrile...). The gas chromatography method is more suitable for analyzing stable volatile non-polar substances up to a weight of approx. 1000 Da. The range of measured substances can be increased for both methods eg., by chemical modifications (derivatization) of the analyzed molecules, which adjust their polarity and volatility (for GC) and/or stability (for LC). We choose a suitable technique or a combination of several techniques based on prior consultation with the customer.</p>
<p>The untargeted analysis results in a list of substances found in the samples, a proposal of probable structures, and an indication of the quantity of individual compounds. We also provide a basic statistical evaluation focusing on looking for differences between the tested sample groups (Figure 4).</p>
<h5><strong>Tips for sample handling:</strong></h5>
<ul>
<li>do not use phosphate buffers in the sample</li>
<li>inform us about sample type, growth medium, chemicals used, etc.</li>
</ul>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/BIOCEV_Introducing_BIOCEV_OMICS_Mass_Spectrometry_Core_Facility_Untargeted_metabolomics_Fig_1_11750e6992.jpg" alt="BIOCEV: Introducing BIOCEV OMICS Mass Spectrometry Core Facility - Untargeted metabolomics Fig. 1."/></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/BIOCEV_Introducing_BIOCEV_OMICS_Mass_Spectrometry_Core_Facility_Untargeted_metabolomics_Fig_2_5ca1521705.jpg" alt="BIOCEV: Introducing BIOCEV OMICS Mass Spectrometry Core Facility - Untargeted metabolomics Fig. 2."/></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/BIOCEV_Introducing_BIOCEV_OMICS_Mass_Spectrometry_Core_Facility_Untargeted_metabolomics_Fig_3_f4f1050fc5.jpg" alt="BIOCEV: Introducing BIOCEV OMICS Mass Spectrometry Core Facility - Untargeted metabolomics Fig. 3."/></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/BIOCEV_Introducing_BIOCEV_OMICS_Mass_Spectrometry_Core_Facility_Untargeted_metabolomics_Fig_4_b3e198dbc9.jpg" alt="BIOCEV: Introducing BIOCEV OMICS Mass Spectrometry Core Facility - Untargeted metabolomics Fig. 4."/></p>
<h4><strong>Targeted metabolomics</strong></h4>
<p>Targeted metabolomics includes analyses of selected metabolites, which are then detected selectively and with greater sensitivity than applying an untargeted approach. It is also possible to quantify substances both relatively and absolutely. In the case of absolute quantification, it is necessary to supply a suitable labeled analog of the determined substance.</p>
<blockquote>
<p><strong>We offer analysis of primary cellular metabolites - see List of substances.</strong></p>
</blockquote>
<blockquote>
<p><strong>We analyze metabolites in tissues, cell pellets, incubation media, and body fluids (plasma, urine...).</strong></p>
</blockquote>
<blockquote>
<p><strong>We also offer the possibility of developing a method for the analysis of substances that are not in the attached list or for other matrices.</strong></p>
</blockquote>
<p>The attached list contains substances with the analysis of which we have experience. We adapt each method to the type of experiment and matrix. We can develop a method for any substance or group of substances capable of being detected by liquid and gas chromatography techniques (both connected to a mass detector or a UV detector in liquid chromatography). In the case of the development of a new method, it is necessary to supply the standards of these substances.</p>
<h5><strong>Tips for sample handling:</strong></h5>
<ul>
<li>do not use phosphate buffers in the sample</li>
<li>inform us about sample type, growth medium, chemicals used, etc.</li>
</ul>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/BIOCEV_Introducing_BIOCEV_OMICS_Mass_Spectrometry_Core_Facility_Targeted_metabolomics_List_of_substances_a6a4198b34.jpg" alt="BIOCEV: Introducing BIOCEV OMICS Mass Spectrometry Core Facility - Targeted metabolomics: List of substances."/></p>
<h3><a href="https://www.biocev.eu/en/services/omics-mass-spectrometry-core-facility.6#core-facility-equipment"><strong>Equipment</strong></a></h3>
<h4><strong>Mass spectrometers</strong></h4>
<h5><strong>Orbitrap Ascend</strong></h5>
<ul>
<li><a href="https://lcms.labrulez.com/library?instrumentationItems=31-32-33-30&amp;mainauthorItems=3&amp;search=Ascend"><strong>Application in the LabRulezLCMS library</strong></a></li>
</ul>
<p>Thermo Scientific Orbitrap Ascend Tribrid mass spectrometer, offering new capabilities for multiplexed proteomics and native protein characterization. The mass spectrometer enables improved sample throughput, versatility and ease-of-use — producing high quality data with simplicity. More samples can be analyzed at lower concentrations, enabling faster, more sensitive analysis, and macromolecule experiments, that were not possible before, can now be achieved. The new Auto-Ready ion source for calibration maximizes convenience, allowing the user to spend more time on the results, and less time on instrument set-up.</p>
<h5><strong>Orbitrap Fusion</strong></h5>
<ul>
<li><a href="https://lcms.labrulez.com/library?instrumentationItems=31-32-33-30&amp;mainauthorItems=3&amp;search=Fusion"><strong>Application in the LabRulezLCMS library</strong></a></li>
</ul>
<p>Mass spectrometer combining Quadrupole, Ion trap and Orbitrap. The quadrupole is used as a mass filter for the selection of precursors, after which the instrument branches and the ions can travel either to the Orbitrap - a very accurate and high-resolution mass analyzer that uses the Fourier transform to determine their mass, or to the collision cell, where they can be fragmented. From there, the path leads either back to the Orbitrap or further to the linear ion trap. This serves as the second mass analyzer in the device. It is less accurate and low-resolution, but provides greater sensitivity and the possibility of ion fragmentation. Fragmentation products can be isolated in the trap and fragmented again. This enables analysis in MS³ and even higher levels of fragmentation.</p>
<h5><strong>TSQ Quantiva Triple Quadrupole Mass Spectrometer</strong></h5>
<ul>
<li><a href="https://lcms.labrulez.com/library?instrumentationItems=31-32-35&amp;mainauthorItems=3&amp;search=Quantiva"><strong>Application in the LabRulezLCMS library</strong></a></li>
</ul>
<h5><strong>Leco - Pegasus® 4D GCxGC-TOFMS</strong></h5>
<ul>
<li><a href="https://gcms.labrulez.com/library?instrumentationItems=3-13-2&amp;mainauthorItems=24&amp;search=4D"><strong>Application in the LabRulezGCMS library</strong></a></li>
</ul>
<h4><strong>Liquid chromatography</strong></h4>
<ul>
<li>nano LC Thermo Dionex Ultimate 3000</li>
<li>LC Thermo Dionex Ultimate 3000</li>
</ul>
<h4><strong>Sample preparation</strong></h4>
<ul>
<li>KingFisher Flex</li>
<li>vacuum concentrator</li>
<li>Low flow fraction collector - Spider</li>
<li>Bioruptor pico - sonication bath</li>
</ul>
<h4><strong>Software</strong></h4>
<ul>
<li>Spectronaut 19</li>
<li>FreeStyle</li>
<li>ChromaTOF 4.5</li>
<li>Proteome Discoverer 2.2</li>
<li>Scaffold Q+S 4.6.1</li>
<li>Compound Discoverer 3.3</li>
<li>TraceFinder</li>
</ul>
<h5><strong>Software - Freeware</strong></h5>
<ul>
<li>LipidHunter</li>
<li>MaxQuant</li>
<li>Perseus</li>
<li>Skyline</li>
</ul>
<h3><a href="https://www.biocev.eu/en/services/omics-mass-spectrometry-core-facility.6#core-facility-team"><strong>Team</strong></a></h3>
<h5><strong>Mgr. Karel Harant</strong></h5>
<ul>
<li>Head of Proteomic Core Facilty</li>
</ul>
<h5><strong>Mgr. Pavel Talacko</strong></h5>
<ul>
<li>Non-targeted proteomics, targeted proteomics</li>
</ul>
<h5><strong>RNDr. Petr Žáček, Ph.D.</strong></h5>
<ul>
<li>GC / MS specialist, small molecule analysis</li>
</ul>
<h5><strong>Mgr. Veronika Ševců</strong></h5>
<ul>
<li>researcher, preparation of proteomic samples</li>
</ul>
<h5><strong>RNDr. Petr Žáček, Ph.D.</strong></h5>
<h5><strong>Mgr. Veronika Ševců</strong></h5>
<ul>
<li>researcher, preparation of proteomic samples</li>
</ul>
<h5><strong>Ing. Olga Součková, Ph.D.</strong></h5>
<ul>
<li>LC/MS specialist, small molecule analysis</li>
</ul>


Introducing BIOCEV OMICS Mass Spectrometry Core Facility

<p><strong>Amyotrophic lateral sclerosis, ALS for short, is a mysterious neurodegenerative disease that is almost always fatal. A consortium of researchers led by the Technical University of Munich (TUM) has systematically investigated the underlying molecular mechanisms of ALS. Among other things, the team discovered that ALS can be divided into subtypes. Depending on the subtype, different drugs could be effective. There are also clear differences in the molecular processes when comparing men and women.</strong></p>
<p>The molecular processes in the body that cause ALS patients to increasingly lose control of motor functions are still poorly understood. Previous studies have been limited to individual aspects of the underlying molecular processes. A consortium led by Prof. Paul Lingor, a neurologist at TUM, has investigated ALS using a so-called &quot;multi-omics&quot; approach. The researchers mapped both coding and non-coding RNA molecules and the entirety of the proteins.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/TUM_Mojan_Parvaz_Insight_into_the_molecular_mechanisms_of_ALS_There_are_hardly_any_drugs_against_ALS_A_new_study_shows_that_a_substance_acting_on_the_MAPK_signaling_pathway_6f7450013b.jpg" alt="Technical University of Munich /  Mojan Parvaz: There are hardly any drugs against ALS. A new study shows that a substance acting on the MAPK signaling pathway may help: After treatment with trametinib, mouse nerve cells (blue) survived better than without."/></p>
<h4><strong>Four subtypes</strong></h4>
<p>A key finding of the study is that ALS can be roughly divided into four subtypes. <em>&quot;You can&#39;t distinguish between these variants based on the clinical symptoms,&quot;</em> says Paul Lingor, who, together with other researchers is part of the <a href="https://www.synergy-munich.de/"><strong>SyNergy Cluster of Excellence</strong></a> investigating neurodegenerative diseases. <em>&quot;However, very different things happen at the molecular level. This means that an active substance that is ineffective in one ALS subtype may well be helpful in another. Previous clinical studies were only able to look at the effects across all patients and may not have identified substances effective for an individual subtype.&quot;</em></p>
<p>While in one common subtype genes associated with inflammatory processes and immune responses were affected, in another there were mainly disturbances in the transcription of DNA into RNA molecules. In two others, different signs of oxidative stress were found in the cells. The researchers assume that the ALS subtype may change over the course of the disease.</p>
<h4><strong>Promising drug identified</strong></h4>
<p>Men develop ALS around 1.2 times more frequently than women. The breakdown of the molecular processes also revealed clear differences between the sexes. While the four subtypes appear to occur equally frequently in both sexes, the researchers found a significantly larger number of altered gene products in men. From the researchers&#39; point of view, this could mean that men and women will have to be treated differently in future.</p>
<p>Through the multi-omics analysis, the researchers also identified a signaling pathway that could be a particularly suitable target for new drugs against ALS. <em>&quot;This signaling pathway, MAPK, is well described in neurobiology and plays a role in various, although by no means all, processes in ALS,&quot;</em> says Prof. Stefan Bonn, co-last author of the study and Director of the Institute for Medical Systems Biology at the University Medical Center Hamburg Eppendorf (UKE). From the researchers&#39; point of view, it would therefore be promising to repurpose an approved cancer drug that acts on MAPK for ALS.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/TUM_Klinikum_rechts_der_Isar_Thomas_Einberger_Insight_into_the_molecular_mechanisms_of_ALS_Prof_Paul_Lingor_is_the_head_of_the_consortium_that_conducted_the_study_98122db927.jpg" alt="Technical University of Munich / Klinikum rechts der Isar / Thomas Einberger: Prof. Paul Lingor is the head of the consortium that conducted the study."/></p>
<h4><strong>Basis for future studies</strong></h4>
<p>The study is based on tissue samples from deceased ALS patients and additional investigations using mouse models of the disease. <em>&quot;An important next step is to find a way to determine the ALS subtype of patients while they are still alive - we are currently working on this,&quot;</em> says Paul Lingor. <em>&quot;We believe that our study made an important contribution in the search for causes and therapies for ALS. Our findings have brought us a good deal closer to a more personalized and therefore more effective therapy.&quot;</em></p>


Insight into the molecular mechanisms of ALS

<p><strong>In the 2 weeks from August 5, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p>
<blockquote>
<h4><a href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4>
</blockquote>
<blockquote>
<p><strong>👉 Search and filter in the largest global database</strong>  with over <strong>3 500 GC, LC, MS and spectroscopy webinars</strong>.</p>
</blockquote>
<h5><strong>1. Phenomenex: Solid Phase Extraction Introduction and Theory</strong></h5>
<ul>
<li>Tu, 6.8.2024 19:00 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/4159">Registration</a></li>
</ul>
<p>Understand the benefit of using SPE than other sample preparation techniques.</p>
<h5><strong>2. C&amp;EN/Metrohm: Smart and Actionable: Spectroscopy PAT-Supported Process Operations</strong></h5>
<ul>
<li>We, 7.8.2024 19:00 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/4175">Registration</a></li>
</ul>
<p>How Albemarle Corporation approached the implementation of Spectroscopy PAT to obtain smarter process operations and what you can do to help drive a mindset change in your business.</p>
<h5><strong>3. Agilent Technologies: Advanced GC/MS | GC/HR-MS Based Workflow for Extractable and Leachable Analysis</strong></h5>
<ul>
<li>Th, 8.8.2024 11:30 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/4136">Registration</a></li>
</ul>
<p>Whether you are scouting or conducting a targeted screening, suspect screening, or nontargeted screening, Agilent can help with a wide range of analytical technologies.</p>
<h5><strong>4. Agilent Technologies: Get the Most Out of Your MS: Novel Column Chemistry Raises the Bar on Sensitivity and Data Accuracy</strong></h5>
<ul>
<li>Tu, 13.8.2024 17:00 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/3908">Registration</a></li>
</ul>
<p>We’ll examine how column attributes like bleed, thermal stability, and inertness can translate into practical data quality improvements.</p>
<h5><strong>5. Phenomenex: Advancing Food Testing Using New and Unique GC Column Selectivities</strong></h5>
<ul>
<li>Tu, 13.8.2024 19:00 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/4161">Registration</a></li>
</ul>
<p>Learn about important applications in food testing and current trends. Recieve an overview of available new column selectivity, and relevant applications.</p>
<h5><strong>6. Shimadzu Corporation: Elevating Pharma 4.0: Harnessing CaliberLIMS For Digital Excellence</strong></h5>
<ul>
<li>We, 14.8.2024 08:30 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/4163">Registration</a></li>
</ul>
<p>CaliberLIMS is a robust, scalable, and reliable platform designed to meet the demands of modern laboratories aiming for Pharma 4.0.</p>
<h5><strong>7. Agilent Technologies: UV-VIS-NIR in Battery Development</strong></h5>
<ul>
<li>Th, 15.8.2024 20:00 CEST</li>
<li><a href="https://gcms.labrulez.com/webinar/3909">Registration</a></li>
</ul>
<p>Agilent&#39;s portfolio of instruments offers the high performance and flexible accessories needed for pioneering new applications.</p>


Webinars LabRulezGCMS Week 32-33/2024

Article

Product

Events

Webinars

Application

Academy

Video

Poster

Scientists

Plastics

Environment

Food

Water

Health

Presentation

Scientific article

Interview

Toxicology

Popularization

Science and research

Software

Covid-19

Career

Laboratories

Various

PFAS 

Zaměření

Type of News

Focus

RECETOX (Research Centre for Toxic Compounds in the Environment) is an independent department of the Faculty of Science of Masaryk University in Brno, which has been established in 1983. RECETOX is focused on the research and education in cross-cutting area of Environment and Health. It addresses interactions among chemicals, environment, and biological systems, including consequences at local, regional, and global levels.

RECETOX - Centrum pro výzkum toxických látek v prostředí

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

The TU Wien is Austria's largest research and educational institution in the field of technology and natural sciences. More than 4,000 scientists are researching "technology for people" in five main research areas at eight faculties. The content of the studies offered is derived from the excellent research. More than 26,000 students in 62 degree programmes benefit from this. As a driver of innovation, TU Wien strengthens the business location, facilitates cooperation and contributes to the prosperity of society.

TU Wien

U.S. Environmental Protection Agency’s (EPA) mission is to protect human health and the environment. EPA works to ensure that: Americans have clean air, land and water; National efforts to reduce environmental risks are based on the best available scientific information; Federal laws protecting human health and the environment are administered and enforced fairly, effectively and as Congress intended; Environmental stewardship is integral to U.S. policies concerning natural resources, human health, economic growth, energy, transportation, agriculture, industry, and international trade, and these factors are similarly considered in establishing environmental policy; All parts of society--communities, individuals, businesses, and state, local and tribal governments--have access to accurate information sufficient to effectively participate in managing human health and environmental risks; Contaminated lands and toxic sites are cleaned up by potentially responsible parties and revitalized; and Chemicals in the marketplace are reviewed for safety.

US Environmental Protection Agency (EPA)

We are America’s first research university, founded in 1876 on the principle that by pursuing big ideas and sharing what we learn, we can make the world a better place. For more than 140 years, our faculty and students have worked side by side in pursuit of discoveries that improve lives.

Johns Hopkins University

Our university combines top-class facilities for cutting-edge research with unique learning opportunities for 48,000 students. Whether our researchers are investigating the origins of life, matter and the universe or looking for solutions to the major challenges for our society, people lie at the heart of our research and innovation agenda. Our goal is to create lasting value for society through excellence in education and research, the active promotion of next-generation talents and a strong entrepreneurial spirit. All of which combine to make TUM one of Europe’s leading universities.

Technical University of Munich -TUM

BIOCEV is a scientific centre of excellence in biotechnology and biomedicine, which aims to detailed study of cellular mechanisms at the molecular level, research and development of novel therapeutic strategies, early diagnostics, biologically active agents including chemo-therapeutics, protein engineering and other technologies. Endowed with superb instruments and equipment, BIOCEV brings together enthusiastic teams of well-trained scientists from six institutes of the Czech Academy of Sciences and two faculties of the Charles University.

Webinars LabRulezGCMS Week 32-33/2024

Insight into the molecular mechanisms of ALS

Introducing BIOCEV OMICS Mass Spectrometry Core Facility

In the next years, climate change will affect everything, says environmental epidemiologist Tomáš Janoš.

News from LabRulezGCMS Library - Week 30, 2024

Johns Hopkins Researchers Find Thousands of Unknown Chemicals in Electronic Cigarettes

Webinars LabRulezGCMS Week 31-32/2024

Nuclear Clocks and the Fundamental Constants of Nature

Atomic Nucleus Excited with Laser: A Breakthrough after Decades

Biden-Harris Administration Reports Significant Progress Toward Protecting Children from Lead Poisoning

Upcoming events

Thermo Fisher Scientific Environmental & Food Safety Workshop Series 2026

LECO Training Course Pegasus BT/BT4D BTX/BTX4D

LECO Separation Science Workshop

Webinars

How to Perform Routine Quantification by FTIR: Tips & Tricks Workshop

Learn How FTIR Can Help You with Contamination and Poor Product Quality

Unlocking New Analytical Possibilities with Waters APGC Solutions