ISC 2026 - Day 2

<h4>What if you could compress 179 days of grueling laboratory workflow into just 14 hours?</h4>In this episode of ‪ChromatographyTalk‬, ‪Organomation‬ General Manager David Oliva sits down with analytical chemist Laura Penabad to discuss her groundbreaking new research in biocatalysis and high-throughput screening. Evolving engineered enzymes typically requires checking thousands of variants—a massive bottleneck when traditional Liquid Chromatography-Mass Spectrometry (LC-MS) runs take minutes per sample. Laura reveals how her team built a modular screening platform that shatters this limitation, running samples 128 times faster than standard methods without sacrificing analytical accuracy.Laura breaks down the "orchestra" of technologies making this possible, including coupling nanoliter droplet microfluidics with Cyclic Ion Mobility-Mass Spectrometry (cIM-MS) to separate complex chemical isomers in milliseconds. She also shares the chaotic but triumphant behind-the-scenes stories of her PhD journey—from presenting a "comically bad" early poster at ASMS to recruiting an undergraduate mechanical engineer to build custom automation software from scratch.If you are an early-career researcher, a mass spec enthusiast, or curious about the future of synthetic biology and machine learning in chemistry, this episode is packed with invaluable intuition and advice.<h3>Video Transcription</h3><h4>From Months to Hours: Droplet Ion Mobility–MS for Biocatalysis Screening</h4>High-throughput screening is central to directed enzyme evolution, but conventional analytical workflows can create a difficult compromise: extremely fast screens often provide limited structural information, while techniques such as LC-MS offer much richer chemical insight at the cost of throughput. In a recent interview, analytical chemist Laura described how her work with droplet-based cyclic ion mobility mass spectrometry is helping bridge that gap—providing rapid analysis while retaining the ability to distinguish structurally similar products.Her research grew from an initially modest proof of concept into a screening platform capable of analyzing a 96-well plate in roughly ten minutes. The resulting workflow was approximately 128 times faster than a conventional three-minute LC-MS analysis, opening new possibilities for directed evolution campaigns in which thousands of enzyme variants need to be evaluated.<h4>Directed evolution needs better analytical screening</h4>Biocatalysis takes advantage of enzymes as highly selective catalysts capable of performing reactions under relatively mild conditions. Directed evolution extends those capabilities by deliberately modifying enzyme sequences, expressing large numbers of variants, screening their activity, and using the best-performing mutants as starting points for subsequent rounds of evolution.The process can be repeated multiple times, progressively steering an enzyme toward improved activity, altered substrate specificity, or even chemistry that does not occur naturally.But the effectiveness of directed evolution depends heavily on the screening step. The more variants that can be analyzed—and the more useful chemical information that can be collected for each one—the more effectively researchers can explore the enormous sequence space available to an enzyme.For Laura, this created a clear analytical challenge: develop a screening platform that was substantially faster than conventional chromatographic analysis without sacrificing the structural discrimination needed for chemically similar products.<h4>From an imperfect first experiment to a working platform</h4>The project did not begin with a polished high-throughput workflow.Laura recalled looking back at her 2023 ASMS poster, where the early system was still working with standards rather than true isomeric samples. Droplet introduction was slow—around six seconds per droplet—and the signals were far from the ideal reproducible, square, flat-topped profiles expected from replicate droplets.Nevertheless, simply producing a droplet signal represented an important first milestone.The decisive change came when the project stopped being treated merely as a demonstration that droplet ion mobility–MS could work and instead became a deliberate effort to build a robust screening platform.Laura approached the problem in modules. First came reliable droplet introduction. Then the ion mobility separation method. Quantification became another independent component. Matrix effects were introduced later, gradually making the system resemble the conditions expected with real screening samples.Each layer was tested before another was added.This stepwise strategy became one of the central principles of the project: rather than attempting to optimize the entire system simultaneously, individual components were developed, challenged, and then assembled into an increasingly realistic workflow.<h4>Finding the middle ground between speed and structural information</h4>One of the biggest analytical problems in high-throughput screening is distinguishing products with the same nominal or exact mass.Constitutional isomers may contain the same atoms and therefore generate the same mass-to-charge ratio, while differing only in how functional groups are arranged within the molecular structure. Very rapid optical or mass-based screens may therefore struggle to distinguish them.Traditional LC-MS can solve many of these problems through chromatographic separation, but a several-minute analysis rapidly becomes impractical when thousands of enzyme variants must be screened.Ion mobility offered Laura’s team another option.Rather than separating compounds on a chromatographic timescale, ion mobility can differentiate ions according to their gas-phase behavior on a much shorter timescale. In the workflow described in the interview, this created a useful compromise: not the kilohertz throughput possible with some simple screening technologies, but dramatically faster structural differentiation than conventional LC-MS.The goal was therefore not simply to achieve the fastest possible screen, but to find a middle-throughput analytical regime with enough resolving power to answer chemically meaningful questions.<h4>A 96-well plate in about ten minutes</h4>That strategy eventually produced one of the most striking results of the project.The droplet cyclic ion mobility–MS platform processed a 96-well plate in roughly ten minutes, while maintaining quantitative results comparable with the conventional LC-MS workflow used for comparison. According to the interview, this represented an approximately 128-fold increase in analysis speed relative to a three-minute LC-MS run.Laura described the successful plate experiment less as a surprise than as confirmation that the modular development strategy had worked.Before reaching that point, the workflow had already been challenged through a sequence of increasingly demanding experiments: droplet formation, ion mobility separation, calibration, matrix-containing calibration, and cross-testing analytes at different concentrations. By the time the complete plate was analyzed, each individual part of the analytical system had already been tested under progressively more realistic conditions.<h4>What does that speed mean for directed evolution?</h4>The impact becomes even clearer when the workflow is considered at the scale of an entire directed-evolution campaign.Laura’s manuscript estimated that a five-round campaign involving 5,000 variants would require approximately 179 days using the conventional LC-MS workflow but only about 14 hours using the new platform.Compressing months of analytical work into less than a day has consequences beyond laboratory productivity.It allows researchers to screen more enzyme variants and therefore sample a larger portion of sequence space. But the resulting datasets may also become increasingly valuable for computational approaches.Rather than retaining information only about the best-performing enzyme variant, researchers can preserve data describing variants that performed poorly as well as those that succeeded. When genotype and phenotype information remain linked through the well-plate workflow, these larger datasets can potentially provide richer input for machine-learning models designed to guide subsequent rounds of enzyme evolution.Faster analysis therefore does more than accelerate an existing experiment—it can change the scale and design of the experiment itself.<h4>Balancing ion mobility resolution and signal</h4>Increasing cyclic ion mobility separation time can improve resolution, but it also introduces an important trade-off: additional passes can reduce signal.Laura optimized this balance experimentally by continuously infusing mixtures containing both isomers and progressively adjusting the ion mobility conditions. After tuning parameters such as wave height and velocity, increasing the separation to three passes provided baseline resolution at the high analyte concentrations used during method development.<blockquote>Concentration, however, also mattered.</blockquote>At higher ion populations, space-charge effects could broaden peaks and reduce the baseline separation. This meant that the optimal number of passes could not be selected independently of the concentration range required by the final assay.Her broader advice for optimization is therefore application-driven: decide first what the analytical method actually needs to accomplish.More speed will almost always require sacrificing something—resolution, signal intensity, quantitative precision, or another performance parameter. The key is to identify which compromise the application can tolerate and then optimize the system around that requirement.<h4>Solving droplet carryover with a practical compromise</h4>Droplet-based workflows present their own engineering challenges, including carryover between neighboring samples.In Laura’s system, analytes showed little tendency to partition into the fluorinated oil separating aqueous droplets within the Teflon tubing. The more troublesome carryover occurred closer to electrospray ionization, where a small amount of sample could remain associated with the interface and appear when the next droplet arrived.Rather than adding excessive engineering complexity to an already elaborate platform, the researchers adopted a pragmatic solution: a sacrificial wash droplet between analytical samples.It is an example of a recurring theme throughout the project. The objective was not to construct the theoretically most sophisticated droplet system, but to create a screening workflow that remained sufficiently robust, reproducible, and practical for large numbers of samples.<h4>High-throughput analysis also requires high-throughput data processing</h4>Accelerating the mass spectrometry experiment created another bottleneck: the data.The instrument produced a continuous intensity-versus-time trace rather than a neatly organized well-plate dataset. With small experiments, Laura could manually identify individual droplets and process the results in spreadsheets. That approach quickly became unrealistic as sample numbers increased.The solution emerged through collaboration with an undergraduate mentee, Aiden, who helped develop a dedicated software tool for processing the continuous traces.Laura defined how the software should behave and how the analytical information should be organized, while Aiden developed the computational implementation. The workflow itself was subsequently adjusted to make automated data processing more reliable—for example, by introducing marker columns that allowed the software to recognize the end of each plate row.The resulting tool can accept the acquired traces together with information about plate dimensions and replicates and automatically return parameters including peak identity, duration, and the corresponding well position. A later version also generated an automatically populated heat map.The experience illustrates how improving analytical throughput often requires simultaneous development of instrumentation, experimental design, and informatics. Making the measurement faster is useful only if the resulting data can be processed at a comparable speed.<h4>Mentoring became part of the scientific process</h4>The software project also reflects another theme Laura emphasized throughout the interview: the value of mentoring.Several younger researchers contributed directly to the development of the final platform. Laura described mentees not simply as additional hands in the laboratory but as scientists capable of proposing their own hypotheses and experimental ideas.Working with undergraduate researchers also influenced the way she organized experiments.Because their available laboratory time was limited, each task needed to have a clear purpose. That encouraged a more disciplined approach to experimental planning: instead of performing experiments simply because they could be done, the team had to ask which experiment would most efficiently answer the next important question.In that sense, mentoring became another mechanism for improving the research itself.<h4>The next step: continuous, automated screening</h4>Despite the dramatic increase in analytical speed, the current workflow still includes manual operations such as loading tubing and connecting the sample stream to the mass spectrometer.The next engineering challenge is therefore automation.Laura described ongoing work using the Venturi effect to pull samples directly from wells into the droplet system. Building on previous work in the laboratory with 96-well plates, she has already tested this approach with as many as 2,000 samples.The long-term direction is clear: continuous and robust droplet generation, automated handling of thousands of samples, rapid ion mobility separation, mass spectrometric detection, and automated reconstruction of the resulting data into plate-based outputs.Combining those elements could move the system closer to the type of large-scale screening required for increasingly ambitious biocatalysis campaigns.<h4>Learning mass spectrometry one problem at a time</h4>Laura also reflected on the broader experience of developing the platform during her PhD.Ion mobility and mass spectrometry initially appeared intimidating, particularly because they combine concepts from analytical chemistry, physical chemistry, separations, instrumentation, and electrical engineering. What eventually changed was not simply learning more facts, but developing the ability to move repeatedly between theory and experiment.An unexpected result sends the researcher back to the underlying theory. A better understanding suggests a modified experiment. That experiment creates another observation, gradually building intuition about how the system behaves.Her advice to early-career scientists is therefore to accept that this process takes time.Advanced analytical techniques may initially appear overwhelming, but understanding develops incrementally through repeated interaction between theory, experimentation, failure, and refinement. Equally important, she emphasized the role of the supportive ion mobility–mass spectrometry community in making a technically demanding field more approachable for young researchers.From the first inconsistent droplets to a platform capable of processing thousands of samples, that iterative mindset ultimately shaped the entire project.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote><blockquote><h4>Concentrating on Chromatography Podcast</h4>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!You can find Concentrating on Chromatography Podcast in podcast apps:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185">Apple podcast</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography">podscan</a></li></ul>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos">YouTube channel</a></blockquote>

Droplet Cyclic Ion Mobility Mass Spec: Compressing Months of Enzyme Screening Into Just 14 Hours

ISC 2026 - Day 3

Article

Events

Video

Scientists

Interview

The International Symposium on Chromatography (ISC) represents the oldest conference series focussing on separation science. ISC symposia have been organised since 1956 in each even year. ISC is internationally recognised as one of the premier meeting series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.

International Symposium on Chromatography - (ISC)

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Linde Nitrogen 5.6 – Gas Cylinder

Linde Nitrogen 5.6 (≥99.9996%) for GC, analytics, and industry. Ultra-high purity gas for purging, protection, and carrier applications.

Nitrogen 5.6 from Linde is an ultra-high purity inert gas with a purity of ≥ 99.9996%, designed for demanding analytical, industrial, and research applications.Its extremely low impurity levels make it particularly suitable for gas chromatography and other analytical techniques where baseline stability and minimal interference are critical. Nitrogen 5.6 is also widely used as a protective, purge, and carrier gas in processes requiring reliable contamination control.Its versatility enables use across multiple industries as well as in advanced scientific research.<h4>Key Features</h4><ul><li>Ultra-high purity ≥ 99.9996% (5.6 grade)</li><li>Extremely low impurity levels</li><li>Chemically inert gas</li><li>Suitable for analytical applications (GC)</li><li>Stable and reproducible performance</li><li>Broad industrial and laboratory use</li></ul><h4>Technical Specifications</h4><ul><li>Gas: nitrogen (N₂)</li><li>Purity: ≥ 99.9996% (5.6 grade)</li><li>Supply form: pressurized gas cylinder<ul><li>10 L (200 bar)</li><li>50 L (200 bar)</li></ul></li></ul><h4>Applications</h4><ul><li>Protective and purge gas in metallurgy and metal processing</li><li>Chemical, food, and electronics industries</li><li>Carrier and protective gas in semiconductor manufacturing</li><li>Zero gas for analytical instruments</li><li>Purging gas in extrusion and system flushing</li><li>Carrier gas in gas chromatography (GC)</li><li>Cooling applications (e.g., shrink fitting)</li><li>Plastics processing</li><li>Construction and food industry</li><li>Biology, medicine, and research</li></ul>

Linde Nitrogen 4.6 – Gas Cylinder

Linde Nitrogen 4.6 (≥99.996%) for industry and analytics. Reliable inert gas for purging, protection, and calibration.

Nitrogen 4.6 from Linde is a high-purity inert gas with a purity of ≥ 99.996%, suitable for a wide range of industrial and analytical applications.Due to its chemical inertness, it is widely used as a protective and purge gas in processes where oxidation or contamination must be prevented. Nitrogen 4.6 is also suitable as a zero gas in analytical instrumentation, providing stable baseline conditions for accurate measurements.In industrial environments, it is commonly used as a cutting gas for laser and plasma cutting of standard materials.<h4>Key Features</h4><ul><li>Purity ≥ 99.996% (4.6 grade)</li><li>Chemically inert gas</li><li>Suitable for protective atmospheres</li><li>Stable performance in analytical applications</li><li>Versatile industrial use</li><li>Supplied in pressurized cylinders</li></ul><h4>Technical Specifications</h4><ul><li>Gas: nitrogen (N₂)</li><li>Purity: ≥ 99.996% (4.6 grade)</li><li>Supply form: pressurized gas cylinder<ul><li>20 l (200 bar)</li><li>50 l (200 bar)</li></ul></li></ul><h4>Applications</h4><ul><li>Protective and purge gas in metallurgy and metal processing</li><li>Chemical, food, and electronics industries</li><li>Carrier and protective gas in semiconductor manufacturing</li><li>Laser and plasma cutting gas</li><li>Zero gas for analytical and measurement systems</li></ul>

Linde Nitrogen 4.0 – Gas Cylinder

Linde Nitrogen 4.0 (≥99.99%) for industrial applications. Reliable inert gas for purging, protection, and cooling.

Nitrogen 4.0 from Linde is a technically pure inert gas with a purity of ≥ 99.99%, designed for a wide range of industrial and technological applications.Due to its chemical inertness, it is widely used as a protective and purging gas in processes where oxidation or unwanted reactions must be prevented. Nitrogen 4.0 is also suitable as a universal cooling medium and is applied across various industrial and research processes.Its robust and versatile performance makes it a cost-effective solution for applications where ultra-high purity is not required.<h4>Key Features</h4><ul><li>Purity ≥ 99.99% (4.0 grade)</li><li>Chemically inert gas</li><li>Suitable for protective and purging applications</li><li>Versatile industrial use</li><li>Suitable as a cooling medium</li><li>Cost-effective solution</li></ul><h4>Technical Specifications</h4><ul><li>Gas: nitrogen (N₂)</li><li>Purity: ≥ 99.99% (4.0 grade)</li><li>Supply form: pressurized gas cylinder<ul><li>10 L (200 bar)</li><li>20 L (200 bar)</li><li>50 L (200 bar)</li><li>50 L (300 bar)</li></ul></li></ul><h4>Applications</h4><ul><li>Protective gas in metallurgical, chemical, food, and electrochemical industries</li><li>Purging gas for pipes and tanks</li><li>Cooling applications (e.g., shrink fitting, plastics processing)</li><li>Construction, food industry, biology, and medicine</li><li>Welding applications (root protection and oxidation prevention)</li></ul>

Linde Nitrogen 5.3 – Gas Cylinder

Linde Nitrogen 5.3 (≥99.999%) for GC, analytics, and industry. High-purity inert gas for purging, protection, and carrier applications.

Nitrogen 5.3 from Linde is a high-purity inert gas with a purity of ≥ 99.999%, suitable for demanding analytical, industrial, and research applications.Its low impurity levels make it ideal as a carrier gas in gas chromatography and as a working gas for analytical instruments. It is also widely used as a protective, purge, and flushing gas in processes requiring a stable inert environment with minimal contamination risk.Nitrogen 5.3 offers an optimal balance between high purity and cost efficiency for a wide range of applications.<h4>Key Features</h4><ul><li>High purity ≥ 99.999% (5.3 grade)</li><li>Low trace impurity levels</li><li>Chemically inert gas</li><li>Suitable for analytical applications (GC)</li><li>Stable and reproducible performance</li><li>Versatile industrial and laboratory use</li></ul><h4>Technical Specifications</h4><ul><li>Gas: nitrogen (N₂)</li><li>Purity: ≥ 99.999% (5.3 grade)</li><li>Supply form: pressurized gas cylinder<ul><li>50 L (200 bar)</li><li>50 L (300 bar)</li></ul></li></ul><h4>Applications</h4><ul><li>Protective and purge gas in metallurgy and metal processing</li><li>Chemical, food, and electronics industries</li><li>Carrier and protective gas in semiconductor manufacturing</li><li>Zero gas for analytical instruments</li><li>Flushing gas for industrial systems</li><li>Carrier gas in gas chromatography (GC)</li><li>Cooling applications (e.g., shrink fitting)</li><li>Plastics processing</li><li>Construction and food industry</li><li>Biology, medicine, and research</li></ul>

Linde Nitrogen 6.0 – Gas Cylinder

Linde Nitrogen 6.0 (≥99.9999%) for GC, semiconductors, and research. Ultra-high purity inert gas for demanding analytical and industrial applications.

Nitrogen 6.0 from Linde is an ultra-high purity inert gas with a purity of ≥ 99.9999%, designed for the most demanding analytical, laboratory, and industrial applications.Its extremely low level of trace impurities makes it ideal for high-sensitivity analytical techniques such as gas chromatography, as well as for semiconductor manufacturing and advanced research. It ensures maximum stability, minimal contamination, and excellent reproducibility.Nitrogen 6.0 is the preferred choice wherever gas purity is critical and precise control of process conditions is required.<h4>Key Features</h4><ul><li>Ultra-high purity ≥ 99.9999% (6.0 grade)</li><li>Extremely low trace impurity levels</li><li>Chemically inert gas</li><li>Ideal for analytical and semiconductor applications</li><li>High stability and reproducibility</li><li>Suitable for high-end applications</li></ul><h4>Technical Specifications</h4><ul><li>Gas: nitrogen (N₂)</li><li>Purity: ≥ 99.9999% (6.0 grade)</li><li>Supply form: pressurized gas cylinder<ul><li>10 l (200 bar)</li><li>50 l (200 bar)</li></ul></li></ul><h4>Applications</h4><ul><li>Protective and purge gas in metallurgy and metal processing</li><li>Chemical, food, and electronics industries</li><li>Carrier and protective gas in semiconductor manufacturing</li><li>Zero gas for analytical instruments</li><li>Flushing gas for industrial systems</li><li>Carrier gas in gas chromatography (GC)</li><li>Cooling applications (e.g., shrink fitting)</li><li>Plastics processing</li><li>Construction and food industry</li><li>Biology, medicine, and research</li></ul>

Linde Food Grade Nitrogen – Gas Cylinder

Food grade nitrogen from Linde for MAP packaging, inerting, and food protection. Prevents oxidation and extends product shelf life.

Food grade nitrogen from Linde is a high-purity inert gas designed for use in the food and beverage industry. It complies with all relevant regulations for food-contact applications.Nitrogen is primarily used to displace oxygen, preventing oxidation, microbial growth, and product degradation. Its inert nature helps extend shelf life while preserving product quality, taste, and appearance.It is suitable for a wide range of applications, including modified atmosphere packaging and beverage inerting.<h4>Key Features</h4><ul><li>Food-grade quality compliant with regulations</li><li>Inert gas with no impact on taste or odor</li><li>Prevents oxidation and microbial growth</li><li>Extends shelf life of products</li><li>Suitable for MAP packaging and inerting</li><li>Colorless and odorless</li></ul><h4>Technical Specifications</h4><ul><li>Gas: nitrogen (N₂)</li><li>Grade: food grade</li><li>Supply form: gas cylinder<ul><li>20 L (200 bar)</li><li>50 L (200 bar)</li></ul></li></ul><h4>Applications</h4><h5>Food Industry:</h5><ul><li>Modified Atmosphere Packaging (MAP)</li><li>Oxygen displacement during packaging</li><li>Storage of oils and fats to prevent oxidation</li><li>Cryogenic cooling and freezing (liquid nitrogen)</li></ul><h5>Beverage Industry:</h5><ul><li>Inerting of beverages and equipment</li><li>Wine preservation and storage</li><li>Shelf-life extension of beverages</li></ul>

Organomation 6 Position N-EVAP Nitrogen Evaporator

Compact nitrogen evaporator for up to 6 samples with precise flow control, heated bath options, and wide sample compatibility.

The Organomation 6 Position N-EVAP is a compact and cost-effective sample concentrator designed for simultaneous evaporation of up to 6 samples. Based on the proven N-EVAP technology developed in the 1970s, it ensures reliable and reproducible solvent evaporation using nitrogen gas within a heated bath.The system supports a wide range of sample sizes – 10–30 mm OD as standard, and up to 30–56 mm OD with an optional holder. The circular rotating design allows easy front access to all samples.<h4>Key Features</h4><ul><li>Evaporation of up to 6 samples simultaneously</li><li>Adjustable nitrogen flow: 0–10 L/min</li><li>Individually adjustable needle valves for precise control</li><li>Circular rotating sample holder for easy access</li><li>Wide sample diameter range: 10–56 mm OD (with optional holder)</li><li>Stainless steel bath construction for durability</li><li>Water or dry bath configurations available</li><li>High temperature limit switch for safety</li><li>Phthalate-free silicone tubing to prevent contamination</li><li>Efficient nitrogen usage with minimal waste</li></ul><h3>Technical Specifications</h3><h4>General</h4><ul><li>Number of positions: 6</li><li>Sample holder layout: Circular</li><li>Gas manifold: Single ring</li><li>Gas flow meter: 0–10 L/min</li><li>Standard sample OD: 10–30 mm</li><li>Optional sample OD: 30–56 mm</li><li>Gas input pressure: 20–30 psig</li><li>With regulator: 30–160 psig</li></ul><h4>Dimensions</h4><ul><li>Water bath: 33 × 28 × 79 cm</li><li>Dry bath: 33 × 28 × 70 cm</li><li>Reduced height: 33 × 28 × 61 cm</li></ul><h4>Needles</h4><ul><li>Length: 4 in (≈10 cm)</li><li>Gauge: 19 ga</li><li>Material: stainless steel + chrome-plated brass hub</li></ul><h4>Heating – Water Bath</h4><ul><li>Temperature range: 30–90 °C</li><li>Power: 550 W</li><li>Controller: mechanical thermostat</li><li>Accuracy: ±2 °C</li></ul><h4>Heating – Dry Bath</h4><ul><li>Temperature range: 40–130 °C</li><li>Power: 500 W</li><li>Medium: aluminum / glass beads</li><li>Accuracy: ±2 °C</li></ul>

Organomation 20 Position Auto N-EVAP Nitrogen Evaporator

The 20 Position Auto N-EVAP enables automated, safe evaporation of up to 20 samples with digital control and pneumatic sample handling.

The Organomation 20 Position Auto N-EVAP is the most advanced nitrogen evaporator developed by Organomation. It combines the classic N-EVAP system with timed automation and optional nitrogen self-generation.The instrument operates in both automatic and manual modes using an integrated pneumatic system. In automatic mode, samples are removed from the heating bath at the end of the cycle, reducing the risk of sample loss or damage.A digital control system provides precise control of gas flow and bath temperature, ensuring safe and reproducible evaporation of up to 20 samples simultaneously.<h4>Key Features</h4><ul><li>Automatic and manual operation modes</li><li>Capacity of up to 20 samples</li><li>Automatic sample removal after cycle completion</li><li>Digital control of temperature and timing</li><li>Nitrogen flow up to 25 L/min</li><li>Built-in pressure reducing regulator</li><li>Dual nitrogen filtration system</li><li>Pneumatic sample lift (gas piston)</li><li>Safety cover and circuit breaker</li><li>Precision needle valve control</li><li>Phthalate-free high-pressure tubing</li><li>Reduced risk of sample loss through automation</li></ul><h4>Available Model</h4><h5>Automatic 20 Position N-EVAP – Water Bath</h5><ul><li>Catalog number: 11220-A</li><li>Bath type: Water</li><li>Number of positions: 20</li><li>Dimensions: 49 × 46 × 92 cm</li><li>Temperature range: 30–100 °C</li><li>Total wattage: 1100 W</li></ul><h5>Standard Features</h5><ul><li>Adjustable flow meter: 0–25 L/min</li><li>Built-in pressure reducing regulator</li><li>Dual nitrogen filters</li><li>Digital temperature controller (LED)</li><li>Electronic timer</li><li>High temperature limit switch</li><li>Safety cover</li><li>Circuit breaker</li><li>High-pressure phthalate-free tubing</li><li>Precision variable valve technology</li><li>Gas piston lift mechanism</li><li>Set of 20 needles (4" × 19 gauge)</li></ul><h4>Options</h4><ul><li>220v wiring harness</li><li>Z-Purge / positive pressure purge case</li><li>Acid resistant coating on instrument and needles</li></ul><h4>Technical Specifications</h4><h4>General</h4><ul><li>Number of positions: 20</li><li>Sample holder layout: Circular</li><li>Gas manifold: Single Ring</li><li>Gas flow rate: 0–25 L/min</li><li>Sample size range: 10–30 mm OD</li><li>Nitrogen input pressure: 30–110 psig</li><li>Acid resistant coating: Optional</li></ul><h4>Needles</h4><ul><li>Size: 102 mm × 19 ga (4")</li><li>Material: stainless steel with plated brass hub</li></ul><h4>Sample Lift Mechanism</h4><ul><li>Type: Gas piston</li><li>Function: automatic lifting/removal of samples</li></ul><h4>Control System</h4><ul><li>Digital temperature control (LED display)</li><li>Electronic timer for gas and heating</li></ul><h4>Heating Specifications</h4><ul><li>Model: 11196</li><li>Medium: Water</li><li>Inside dimensions: 11 × 11 × 5.5 in</li><li>Outside dimensions: 49 × 46 × 18 cm</li><li>Power: 1100 W</li><li>Temperature range: 30–100 °C</li><li>Controller: digital electronic</li><li>Accuracy: ±2 °C</li></ul><h4>Accessories</h4><ul><li>Nitrogen generator (20 L/min)</li><li>Pasteur pipette adapters</li><li>Pressure reducing regulator 0–160 psi</li><li>High temperature silicone fluid</li><li>Various needle sizes and gauges</li></ul><h4>Replacement Parts</h4><ul><li>NA1955 – Nitrogen generator</li><li>NA0603 – Needles 4" × 19 ga</li><li>NA0636 – Pasteur pipette adapter</li></ul>

Organomation 9 Position MULTIVAP Nitrogen Evaporator

The MULTIVAP 9 Position enables rapid evaporation of large-volume samples using a high-temperature dry block and efficient row-based nitrogen control.

The Organomation 9 Position MULTIVAP is a high-temperature dry block nitrogen evaporator designed for large volume sample evaporation.The system features a rectangular 3×3 gas distribution manifold and a dual post lifting assembly, allowing easy adjustment of needles or pipettes. Nitrogen is directed onto the sample surface, enabling rapid solvent evaporation and efficient sample concentration.Each row of three positions can be individually switched on/off, allowing significant nitrogen savings when processing fewer samples.The system operates with a heated aluminum dry block (30–120 °C) or as an ambient (unheated) version.<h4>Key Features</h4><ul><li>Up to 9 samples simultaneously (3×3 layout)</li><li>High-temperature dry block: 30–120 °C</li><li>Ambient (unheated) version available</li><li>Direct nitrogen delivery onto sample surface</li><li>Row-based gas control (3 samples per row)</li><li>Nitrogen flow range: 0–25 L/min</li><li>Built-in pressure regulator</li><li>Digital temperature control and timer</li><li>Dual spring hoist lifting system</li><li>Includes 50 mm OD beakers</li><li>Custom inserts available for different sample sizes</li><li>Compatible with organic solvents</li><li>Optional acid-resistant configuration</li></ul><h4>Available Models</h4><h5>9 Position MULTIVAP – Dry Block</h5><ul><li>Catalog number: 11809</li><li>Heating type: Dry block</li><li>Number of positions: 9</li><li>Dimensions: 41 × 36 × 76 cm</li><li>Temperature range: 30–120 °C</li><li>Power: 900 W</li></ul><h5>9 Position MULTIVAP – No Heating</h5><ul><li>Catalog number: 11809-O</li><li>Heating type: None</li><li>Number of positions: 9</li><li>Dimensions: 33 × 38 × 66 cm</li><li>Temperature: Ambient</li></ul><h4>Standard Features</h4><ul><li>Adjustable flow meter: 0–25 L/min</li><li>Gas distribution manifold (3×3)</li><li>Nitrogen filter</li><li>Built-in pressure reducing regulator</li><li>Electronic timer</li><li>Digital temperature controller (LED)</li><li>Safety control cover plate</li><li>High temperature limit switch</li><li>Dual band hoist spring assembly</li><li>9 beakers (50 mm OD included)</li></ul><h4>Options</h4><ul><li>220v wiring harness</li><li>Z-Purge / positive pressure purge case</li><li>Acid resistant coating</li><li>Pasteur pipette adapters instead of needles</li><li>Manifold and stand only (no heating platform)</li></ul><h3>Technical Specifications</h3><h4>General</h4><ul><li>Number of positions: 9</li><li>Layout: Rectangular (3×3)</li><li>Spacing: 5.87 cm</li><li>Standard vessels: 50 mm OD beakers</li><li>Optional tube range: 16–40 mm OD</li><li>Gas flow: 0–25 L/min</li><li>Flow control: per row (3 samples)</li><li>Gas input pressure: 30–110 psig</li><li>Acid resistant coating: Optional</li></ul><h4>Needles</h4><ul><li>Size: 102 mm × 16 ga</li><li>Material: stainless steel</li><li>Needle guide: optional for tubes</li></ul><h4>Lift Mechanism</h4><ul><li>Type: Dual pulley &amp; band springs</li><li>Function: adjustable needle height</li></ul><h4>Heating Specifications</h4><ul><li>Model: 9156</li><li>Type: Aluminum dry block</li><li>Dimensions: 41 × 36 × 15 cm</li><li>Power: 900 W</li><li>Temperature range: 30–120 °C</li><li>Controller: digital electronic (LED)</li><li>Accuracy: ±2 °C</li></ul><h4>Accessories</h4><ul><li>Nitrogen generator</li><li>Custom inserts&nbsp;</li><li>Pasteur pipette adapters</li><li>Luer plugs</li><li>Various needle sizes and gauges</li></ul>

Organomation 30 Position MULTIVAP Nitrogen Evaporator

The MULTIVAP 30 Position enables high-throughput evaporation of up to 30 samples with a heated dry block, efficient gas control, and custom inserts.

The Organomation 30 Position MULTIVAP is a high-capacity dry block nitrogen evaporator designed for parallel evaporation of up to 30 samples.The system features a rectangular 5×6 gas distribution manifold and a dual post lifting assembly. Nitrogen is directed onto the sample surface, enabling rapid solvent evaporation and efficient concentration.Each row of 5 samples can be independently switched on/off, allowing significant nitrogen savings when processing fewer samples.The system operates with a heated aluminum dry block (30–120 °C) or as an ambient (unheated) version. Custom-made inserts and blocks ensure optimal heat transfer for specific sample sizes.<h4>Key Features</h4><ul><li>Up to 30 samples simultaneously (5×6 layout)</li><li>High-temperature dry block: 30–120 °C</li><li>Ambient (no heating) version available</li><li>Direct nitrogen blowdown onto sample surface</li><li>Row-based gas control (5 samples per row)</li><li>Nitrogen flow: 0–25 L/min</li><li>Built-in pressure regulator</li><li>Digital temperature control and timer</li><li>Dual spring hoist system</li><li>Custom inserts for optimized heat transfer</li><li>Compatible with organic solvents</li><li>Optional acid-resistant version</li></ul><h4>Available Models</h4><h5>30 Position MULTIVAP – Dry Block</h5><ul><li>Catalog number: 11830</li><li>Heating type: Dry block</li><li>Number of positions: 30</li><li>Dimensions: 41 × 36 × 76 cm</li><li>Temperature range: 30–120 °C</li><li>Power: 900 W</li></ul><h5>30 Position MULTIVAP – No Heating</h5><ul><li>Catalog number: 11830-O</li><li>Heating type: None</li><li>Number of positions: 30</li><li>Dimensions: 33 × 38 × 66 cm</li><li>Temperature: Ambient</li></ul><h4>Standard Features</h4><ul><li>Adjustable flow meter: 0–25 L/min</li><li>Gas distribution manifold (5×6)</li><li>Nitrogen filter</li><li>Built-in pressure reducing regulator</li><li>Digital temperature controller (LED)</li><li>Electronic timer</li><li>Safety control cover plate</li><li>High temperature limit switch</li><li>Dual band hoist spring assembly</li></ul><h4>Options</h4><ul><li>220v wiring harness</li><li>Z-Purge / positive pressure purge case</li><li>Acid resistant coating</li><li>Pasteur pipette adapters instead of needles</li><li>Manifold and stand only (no heating platform)</li></ul><h3>Technical Specifications</h3><h4>General</h4><ul><li>Number of positions: 30</li><li>Layout: Rectangular (5×6)</li><li>Spacing: 3.33 cm</li><li>Sample diameter range: 16–30 mm OD</li><li>Gas flow: 0–25 L/min</li><li>Flow control: per row (5 samples)</li><li>Gas input pressure: 30–110 psig</li><li>Acid resistant coating: Optional</li></ul><h4>Needles</h4><ul><li>Size: 102 mm × 19 ga</li><li>Material: stainless steel</li><li>Needle guide: optional</li></ul><h4>Lift Mechanism</h4><ul><li>Type: Dual pulley &amp; band springs</li><li>Function: adjustable needle height</li></ul><h4>Heating Specifications</h4><ul><li>Model: 9156</li><li>Type: Aluminum dry block</li><li>Dimensions: 41 × 36 × 15 cm</li><li>Power: 900 W</li><li>Temperature range: 30–120 °C</li><li>Controller: digital electronic (LED)</li><li>Accuracy: ±2 °C</li></ul><h4>Accessories</h4><ul><li>Nitrogen generator</li><li>Custom inserts</li><li>Pasteur pipette adapters (not compatible with needle guide)</li><li>Luer plugs</li><li>Various needle sizes and gauges</li></ul>

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