<p><strong>An international team led by researchers from CEITEC Masaryk University has developed a computational method for designing entirely new antimicrobial peptides – short proteins capable of killing bacteria. Instead of relying on the lengthy process of searching for suitable molecules in nature, the researchers can now use molecular simulations to predict their properties and design new molecules with specific functions. The resulting peptides successfully eliminated bacteria resistant to conventional antibiotics and proved effective in preclinical mouse models. The findings introduce a new approach to developing future antibiotics as well as other biologically active peptides.</strong></p><p>According to the World Health Organization, antibiotic resistance is one of the greatest global health threats of our time. Every year, the number of bacteria resistant to available antibiotics continues to grow. At the same time, developing new drugs is a lengthy and costly process in which most candidate molecules ultimately fail.</p><p>Researchers at <strong>CEITEC Masaryk University </strong>have therefore taken a different approach. Rather than searching randomly for antimicrobial compounds, they developed a method for designing them based on molecular design principles. Using molecular simulations, they analysed around <strong>150 peptides</strong> in detail and identified the rules that govern the design of molecules capable of forming stable pores in bacterial membranes. These tiny openings disrupt the membrane barrier, causing bacteria to lose control of their internal environment and ultimately die. <i>"We discovered how to arrange specific amino acids so that the resulting peptides form pores in bacterial membranes. This now allows us to generate an enormous number of peptide candidates and select those with the properties we are looking for,"</i> says <a target="_blank" rel="noopener noreferrer" href="https://www.ceitec.eu/prof-robert-vacha-ph-d/u27252"><strong>Robert Vácha</strong></a> from<strong> CEITEC Masaryk University</strong>, who led the research.</p><p>The researchers validated the most promising peptide designs experimentally. They confirmed their activity against a group of the most dangerous antibiotic-resistant bacteria. The best results were achieved against <strong>Acinetobacter baumannii</strong>, which the World Health Organization classifies as a priority drug-resistant pathogen. The team also demonstrated that their most successful peptide does not damage human red blood cells and shows no significant toxicity towards human cells. Its efficacy was further confirmed in two preclinical mouse models of bacterial infection.</p><p>The significance of the study lies not only in identifying a new antibiotic candidate but, more importantly, in establishing a new design strategy. Based on their findings, the researchers developed a set of design principles and 52 sequence templates that can be used to design approximately<strong> 10 trillion molecules</strong>, providing other research teams with a framework for developing new membrane-disrupting peptides. The same principle that proved successful against bacteria could also be applied in the future to develop anticancer therapeutics, biosensors, or targeted drug delivery systems.</p><p><i>"Until now, researchers have mostly searched for biologically active molecules created by nature and only then investigated how they work. We reversed this process. First, we studied which molecular properties are required for a particular mechanism of action – in our case, the ability to stabilize membrane pores – and then used this knowledge to design entirely new peptides that make such pores. This approach could significantly accelerate the development of new medicines and help us keep pace with the growing challenge of antibiotic resistance,"</i> adds Robert Vácha, who has received <strong>ERC grants</strong> for his research.</p><p>The study was carried out in collaboration with researchers from the <strong>University of Pennsylvania, the University of Groningen, Palacký University Olomouc, and the Institute of Microbiology of the Czech Academy of Sciences</strong>. The results were published in <a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41589-026-02269-z.epdf"><strong>Nature Chemical Biology</strong></a>.</p><blockquote><h4><strong>The original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41589-026-02269-z#citeas"><strong>Computational design of antimicrobial peptide nanopores</strong></a></h4><p>Rahul Deb, Marcelo D. T. Torres, Ivo Kabelka, Jan Přibyl, Kateřina Dvořáková Bendová, Edo Vreeker, Markéta Koběrská, Gabriela Balíková Novotná, Miloš Petřík, Giovanni Maglia, Cesar de la Fuente-Nunez &amp; Robert Vácha</p><p><i><strong>Nat. Chem. Biol.</strong></i>, 2026, <strong>22</strong>, 1–12</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1038/s41589-026-02269-z"><span>https://doi.org/10.1038/s41589-026-02269-z</span></a><span>&nbsp;</span></p><h6>Licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>Antibiotic resistance is a global health threat, driving the need for new molecules that kill bacteria via nontraditional mechanisms. Here, we present a computational de novo design strategy for α-helical peptides that self-assemble into large, stable and membrane-spanning nanopores with antimicrobial activity, including in vivo efficacy against drug-resistant pathogens. Molecular dynamics simulations guided the selection of sequences for transmembrane barrel-stave pore formation, which were validated by microscopy, electrophysiology and fluorescence assays. Using computational and experimental analyses, including negative design controls, we developed general design guidelines and 52 modular sequence templates with tunable antimicrobial, pore-forming properties. Mechanistic studies confirmed bacterial cytoplasmic membrane disruption via designed nanopore formation. A tuned lead peptide selectively killed drug-resistant ESKAPEE bacteria, including <i>Acinetobacter baumannii</i>, without harming human cells, and showed anti-infective efficacy in preclinical mouse infection models. The framework presented here enables the design of synthetic peptide nanopores for precision antimicrobials, anticancer agents, molecular sensors and delivery systems.</p>

New Antibiotics Designed on a Computer: Scientists Develop a Blueprint for Building Molecules Against Drug-Resistant Bacteria 

<p><strong>A new study published in Nucleic Acids Research identifies short “start–stop” elements as highly effective regulators of protein synthesis in human cells. The study was co-led by Leoš Shivaya Valášek from IMIC CAS.</strong></p><section><div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MBU_Nenapadne_start_stop_brany_reguluji_tvorbu_bilkovin_v_bunce_2_4d91bb348d.jpg" alt="MBU: Unassuming Start–Stop “Gates” Regulate Protein Production in Cells" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MBU_Nenapadne_start_stop_brany_reguluji_tvorbu_bilkovin_v_bunce_2_4d91bb348d.jpg 245w," sizes="100vw" width="720" height="390"></p><section><div><p>An international team of scientists has described a&nbsp;previously overlooked mechanism that regulates the levels of important proteins in human cells. A new study published in <strong>Nucleic Acids Research </strong>reveals that short regulatory “start–stop“ elements act as highly effective speed-limiting gates of protein synthesis. Compared with previously known regulatory sequences, these elements were found to suppress protein production even more efficiently. At the same time, they help maintain low but stable levels of important proteins in cells, even under stress conditions. The study brought together scientists from the <strong>United States, the Czech Republic, Canada, and Sweden</strong>. <strong>Leoš Shivaya Valášek</strong>, Head of the <strong>Laboratory of Regulation of Gene Expression </strong>at the <strong>Institute of Microbiology of the Czech Academy of Sciences (IMIC CAS)</strong> was a&nbsp;co-author and one of the corresponding authors of the study.</p></div></section><section><div><p>During protein production, ribosomes read and translate information encoded in messenger RNA (mRNA) into amino acids, which are then assembled into a&nbsp;new protein. The researchers focused on an unusual sequence in which a&nbsp;start signal is immediately followed by a&nbsp;stop signal. As a&nbsp;result, the ribosome receives instructions to begin and terminate translation almost simultaneously. Although such an arrangement may appear illogical, it proved to be an important regulatory tool.</p><p><strong>Start–stop motifs </strong>are found in more than <strong>1,400 human genes</strong> and are particularly common in genes that control cellular signaling pathways, the stress response, or the activity of transcription factors—that is, proteins that regulate the activity of other genes. These genes must be tightly controlled because even small changes in the amount of their protein products can have significant biological consequences.</p><h4><strong>Resilience Under Stress</strong></h4><p>The researchers tested the activity of this regulatory mechanism under stress conditions, including in the ATF4 gene, which plays a&nbsp;key role in the so-called integrated stress response. Cellular stress is typically associated with a&nbsp;global reduction in protein synthesis. The authors demonstrated that regulation mediated by start-stop elements is largely independent of the overall state of translation initiation and therefore remains effective even under cellular stress.</p><h4><strong>A Stronger Brake Than Known Regulatory Elements</strong></h4><p>The team compared start–stop sequences with similar regulatory regions known as uTranslons. Although both types of elements suppress protein synthesis, the start–stop sequences proved to be significantly more effective. Ribosomes remain associated with these motives for longer before proceeding to the main coding region of the gene.</p><p><i>“Start-stop sequences are specialized regulatory elements that ensure increased ribosome retention, thereby allowing for fine-tuning translation,” </i>says Leoš Valášek from IMIC CAS.</p><p>The study expands our understanding of how cells fine-tune protein synthesis and may ultimately contribute to research on &nbsp;certain cancer and neurodegenerative disorders, and other diseases linked to disrupted protein production.</p></div></section><blockquote><h4><strong>The original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://academic.oup.com/nar/article/54/13/gkag627/8725953?login=false"><strong>Elongationless start–stop elements are stress-resilient translation gates that are more repressive than uTranslons</strong></a></h4><p>Justin Rendleman, Solomon A Haizel, Shaohuan Wu, Laurelle Lee Young, Junjie Liu, Xinyi Ge, Huijing Zou, Mahabub Pasha Mohammad, Matthew Pressler, Shuvadeep Maity, Vladislava Hronová, Zhaofeng Gao, Anna Hermannová, Anna Smirnova, Amy Lei, Kristina Allgoewer, Daniel Sultanov, Will Edward Hinckley, Ziyue Cheng, Lauren Shelby, Tanubrata Dey, Krzysztof J Szkop, Ivan Topisirovic, Ola Larsson, Maria Hatzoglou, Leoš Shivaya Valášek, Christine Vogel</p><p><i><strong>Nucleic Acids Research</strong> </i>(2026), Volume 54, Issue 13&nbsp;</p><p><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1093/nar/gkag627">https://doi.org/10.1093/nar/gkag627</a></p><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><h4><strong>Abstract</strong></h4><p>Start–stop elements are translation regulatory elements in 5′ untranslated regions (UTR) of eukaryotic transcripts, consisting of a start codon immediately followed by a stop codon. In contrast to canonical upstream Translons (uTranslons), they exclude elongation which creates unique properties. We conducted a comprehensive, carefully controlled comparison of human start–stop elements and uTranslons both at a genome-wide level and with targeted reporter assays. We found that start–stops and uTranslons were similar with respect to their presence in the 5′ UTRs of hundreds of genes, in particular transcription factors and signaling molecules, the low transcript levels of the corresponding genes, short RNA half-lives, and the negative effect on downstream translation. However, start–stop containing genes were translationally even more repressed than genes with uTranslons. Analysing the start–stop architecture and diverse ribosome footprinting datasets, we found evidence for a start–stop-specific mechanism that involves repeat cycling between initiation, termination, ribosome splitting, and 60S rejoining—a process possibly modulated by ASCC3 and eIF1. This cycling explained increased ribosome retention at start–stops and was—in contrast to ribosome retention at uTranslons—independent of the global initiation state. Finally, we showed that the start–stop element in human <i>ATF4</i> augments the core regulatory model by controlling translation of the uTranslons.</p></div></section>

Unassuming Start–Stop “Gates” Regulate Protein Production in Cells

Why Biologics QC Is So Much Harder Than Small Molecule Pharma

Article

Scientists

Interview

Science and research

The Czech Academy of Sciences (CAS) was established by Act No. 283/1992 Coll. as the Czech successor of the former Czechoslovak Academy of Sciences. It is set up as a complex of 54 public research institutions.

Czech Academy of Sciences

Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Agilent Technologies

Technology Networks

Phenomenex

Thermo Fisher Scientific

SelectScience

SciY/Mestrelab Research

Waters Corporation

<p><strong>Laboratories are under growing pressure to handle increasing volumes of samples and data while operating under tighter regulatory inspection, all without compromising turnaround times or traceability. In this context, many organizations attempt to extend existing workflows and legacy tools, which can introduce inefficiencies, increase manual effort, and create compliance risks. At the same time, it is not always clear which digital solutions are best suited to address these challenges.</strong></p><p>This presentation illustrates how modern digital laboratory environments streamline routine activities by minimizing manual tasks and embedding compliance directly into everyday workflows. Drawing on a real-world use case, we show how automated capture of data from multiple sample measurements at the point of execution enables a continuous, sample-centric workflow.</p><p>By removing manual interventions and paper-based processes, laboratories can improve efficiency and visibility, support faster and more reliable decision-making while remaining responsive to evolving customer demands.</p><h4><strong>Learning Points</strong></h4><ul><li>The role of different systems (LIMS, SDMS, ELN) within the digital lab landscape and how they differ from each other's</li><li>How WebLab manages laboratory operations from a sample perspective, enabling you to track every sample, stage, and next action across workflows</li><li>How automated data capture from connected instruments helps reduce errors, lower contamination risks, and accelerate sample processing</li><li>You will see, through a real-life example, how integrated digital workflows improve data quality, accelerate reporting, and increase operational efficiency</li></ul><h4><strong>Who should attend</strong></h4><p>Professionals working in small to mid‑sized laboratories, including:</p><ul><li>Directors and Managers of Analytical, QC, or Contract Labs</li><li>Lab Operations and QA/QC Leaders</li><li>Digitalization and IT at organizations transitioning from paper, Excel, or legacy systems to LIMS</li></ul><blockquote><p><strong>Presenter:</strong> Peter Bellstedt, PhD (Director of Business Development and Product Manager at SciY)</p><p>Peter studied Biochemistry at the University of Jena before completing a PhD on the structural characterization of a DNA repair protein using solution and solid-state NMR. He was then appointed as the head of the NMR Spectroscopy Platform in Jena, Germany, where he pioneered the implementation of modern, highly efficient data-driven workflows. After five years, he moved to the University of Zurich, Switzerland, as a principal investigator, where his lab focused on structure-based drug discovery. This year, he brought his wealth of experience to the LOGS by SciY team, focusing on efficient workflow solutions for research labs and facilities on a global scale.</p></blockquote>

SciY: From Legacy Workflows to Paperless Labs: Track Every Sample, Process, and Decision

From Legacy Workflows to Paperless Labs: Track Every Sample, Process, and Decision

Transition from paper to a paperless lab. Discover how WebLab, LIMS, and automated data capture streamline sample tracking and boost compliance

Paperless Labs & Sample Tracking: Digital LIMS Workflows

<h4><strong>How about a 30 minute coffee break along with a bite of Empower?</strong></h4><h5><strong>Here you go!</strong></h5><p><strong>Faster Root Cause Analysis with Next-Generation LC and Empower™ Software</strong></p><p>Discover how next-generation LC systems connected to Empower software automatically capture critical system and method data, enabling faster troubleshooting and root cause analysis. Learn how to quickly identify the causes of peak tailing, reduced resolution, lower sensitivity, and other routine deviations while improving laboratory efficiency and confidence in your results.</p><h5><strong>Key takeaways:</strong></h5><ul><li>Automated data capture with connected LC systems and Empower</li><li>Faster identification of chromatographic issues</li><li>Improved troubleshooting efficiency and reduced downtime</li><li>Enhanced data integrity and compliance support</li></ul><p><strong>Prepare a coffee and attend!</strong></p><blockquote><p><strong>Speaker:</strong> Ralf Schröder (Informatics Market Development Manager)</p><p><strong>Speaker:</strong> Andrea Gheduzzi (Principal LC Market Development Manager)</p></blockquote>

Informatics series #34 Ready for Self-Documenting Chromatography?

Discover self-documenting LC with Waters Empower. Learn how connected LC systems automate root cause analysis and reduce troubleshooting downtime

Informatics series #34 Self-Documenting LC & Empower

<div><p><strong>Rapid microbial analysis is essential for maintaining product quality, ensuring safety, and supporting efficient laboratory workflows, yet selecting the most appropriate analytical approach can be challenging.</strong></p><p>This educational webinar explores three complementary methods—matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for microbial identification, Fourier transform infrared (FTIR) spectroscopy for microbial strain typing, and automated DNA/RNA electrophoresis for genetic analysis.</p><p>Through practical examples and application-focused discussion, attendees will gain a clearer understanding of each technique's strengths, limitations, and ideal use cases, helping them make more informed decisions when designing or optimizing microbial testing workflows.</p><p><strong>Attend this webinar to:</strong></p><ul><li>Understand how MALDI-TOF MS, FTIR, and automated DNA/RNA electrophoresis address different microbial analysis challenges</li><li>Learn how these three methods can support faster and more efficient microbial testing workflows</li><li>Evaluate which analytical approach is best suited to specific microbial testing applications and laboratory objectives</li><li>Apply practical considerations when implementing microbial identification, bacterial classification, or genetic analysis techniques in routine testing</li></ul><blockquote><p><strong>Presenter:</strong> Kaoru Nakagawa (Assistant Manager, Application Specialist (MALDI), Shimadzu Corporation)</p><p>Kaoru Nakagawa joined Shimadzu Corporation in 2008. She began her career at the Koichi Tanaka Mass Spectrometry Research Laboratory, where she developed highly sensitive glycan analysis methods using MALDI-MS with liquid-matrix-based on-plate labeling. Kaoru later moved to a customer-facing role, supporting applications such as, MALDI-MS imaging technologies, including on-tissue chemical derivatization. Today, her work focuses on developing rapid, practical methods for microbial identification using MALDI. Guided by Shimadzu’s corporate philosophy, “Contributing to society through science and technology,” she is dedicated to advancing mass spectrometry technologies that help address real-world scientific challenges.</p></blockquote><blockquote><p><strong>Presenter: </strong>Nozomi Maeshima (Assistant Manager, Application Specialist (Life Science), Shimadzu Corporation)</p><p>Nozomi Maeshima is an applications scientist at Shimadzu, where she has been involved in LC-MS application development in the life sciences field and in genetic analysis applications. She also leads promotional and marketing activities and supports customer inquiries. During university, she studied chemical biology and investigated the mechanisms of enzymes involved in biosynthetic processes. Nozomi brings a combination of research experience and applications expertise to help laboratories identify practical solutions for their analytical needs.</p></blockquote><blockquote><p><strong>Presenter:</strong> Xu Yan ( Assistant Manager, Application Specialist (FTIR), Shimadzu Corporation)</p><p>Xu Yan is an application chemist at Shimadzu Corporation with five years of experience developing FTIR applications for microbiology, environmental analysis, and GX-related fields. His work focuses on advancing practical FTIR applications and has gained extensive experience in method development and real-world implementation. In this session, Xu will present insights into the use of FTIR for microbiological analysis, including strain typing and related applications.</p></blockquote></div>

Technology Networks: Modern Methods for Faster Microbial Analysis

Modern Methods for Faster Microbial Analysis

Explore modern microbial analysis methods. Learn how MALDI-TOF MS, FTIR, and automated electrophoresis streamline identification, strain typing, and genetics

Modern Microbial Analysis: MALDI-TOF, FTIR & Electrophoresis

<p><strong>Wastewater surveillance has become an increasingly valuable approach for monitoring antimicrobial resistance (AMR) within a One Health framework. &nbsp;However, comprehensive characterization of antimicrobial resistance genes (ARGs) in complex environmental samples remains challenging using conventional methodologies alone.</strong></p><p>Join Helena Torrell, PhD, and Douglas Hurd, PhD, for a webinar discussing the challenges of antimicrobial resistance (AMR) surveillance in complex environmental samples and the growing need for sensitive, targeted genomic approaches. &nbsp;Douglas will provide an overview of Agilent’s SureSelect target enrichment technology prior to Next Generation Sequencing and its role in enhancing the detection of low-abundance gene sequences, before introducing guest speaker Helena Torrell, PhD. Helena will share her team’s innovative application of targeted hybridization capture for wastewater-based AMR surveillance.</p><p>This presentation will introduce a targeted hybridization capture strategy we developed to enhance the detection and characterization of known ARGs in environmental samples. &nbsp;Using hospital wastewater as a case study, the presentation will discuss the outstanding performance of our targeted enrichment approach for AMR surveillance, demonstrating its potential advantages and comparing its performance with untargeted shotgun metagenomic sequencing. The session will also address the opportunities and current limitations of targeted capture technologies for environmental resistome monitoring and their potential role in future surveillance programs.</p><h4><strong>Learning Objectives:</strong></h4><ol style="list-style-type:decimal;"><li>Learn how targeted capture improves ARG detection and environmental samples.</li><li>Compare targeted enrichment with shotgun metagenomic sequencing for AMR surveillance.</li><li>Explore the benefits and limitations of targeted capture for resistome monitoring</li></ol><blockquote><p><strong>Presenter:</strong> &nbsp;Helena Torrell Galceran, PhD ( Head of the Genomics Platform, Omic Sciences Unit, Eurecat Technology Center, Barcelona, Spain)</p><p>Helena Torrell, PhD in Biomedicine, is the Head of the Genomics Platform within the Omic Sciences Unit at Eurecat Technology Center (Barcelona, Spain). &nbsp;She specializes in microbial genomics, metagenomics, and next-generation sequencing technologies, with a particular focus on developing genomic tools for infectious disease research, antimicrobial resistance surveillance, and environmental monitoring. &nbsp;She leads the implementation of advanced sequencing technologies and supports multidisciplinary research projects aimed at translating genomic into practical applications for public health, clinical research, and the One Health framework.&nbsp;</p></blockquote><blockquote><p><strong>Presenter: &nbsp;</strong>Douglas Hurd, PhD (Field Application Scientist, Agilent)</p><p>Dr. Douglas Hurd has worked in Customer support and R&amp;D roles for many years within the Biotechnology industry. &nbsp;He currently supports Agilent’s genomics instrumentation and reagents, as well as the Automated electrophoresis instruments such as the TapeStation, Fragment Analyzer, and ProteoAnalyzer.</p></blockquote>

Agilent: Targeted Hybridization Capture for Antimicrobial Resistance Surveillance in Complex Environmental Samples

Targeted Hybridization Capture for Antimicrobial Resistance Surveillance in Complex Environmental Samples

Learn how Agilent SureSelect targeted hybridization capture enhances AMR surveillance and low-abundance ARG detection in complex wastewater samples

Targeted Capture for AMR Surveillance in Wastewater

<p><strong>Understanding the tissue microenvironment in tumour samples is an important factor for predicting response to different treatment regimens. Highly multiplexed imaging of tenfolds of protein markers can help to define this complex biology. However, these assays are costly and not always easy to scale for larger translational studies that are often needed to translate findings to clinical evidence.&nbsp;</strong></p><p>In this webinar, we demonstrate how we move from a highly multiplexed imaging platform used in a discovery phase to identify a marker for response prediction to immunotherapy at the translational phase. This transition was possible with the use of the Invitrogen™ EVOS™ S1000 Spatial Imaging System in combination with the Invitrogen™ Aluora™ Spatial Amplification Kits and a panel of 6 markers. By focusing on the most relevant targets from the discovery panel, the cost per sample is reduced to about 25 % of the initial assay, thereby resulting in a more affordable option for larger translational cohort studies. In addition, we show how relevant protein markers can be combined with in situ proximity Ligation Assay (is PLA) to simultaneously look at protein interactions, in this case demonstrated for PD-1/PD-L1. In summary, this workflow enables scalable, cost-effective spatial biology approaches that bridge discovery and clinical translation.&nbsp;</p><h4><strong>Learning Objectives:</strong></h4><ul><li>Learn how to transition from discovery to translational proteomic imaging assays&nbsp;</li><li>Understand how spectral imaging with the EVOS S1000 Spatial Imaging System can be used for hypothesis-driven research</li><li>Explore the use of spatial amplification reagents for exploring the tissue microenvironment</li></ul><blockquote><p><strong>Presenter: </strong>Charlotte Stadler, PhD (Co-director of Spatial Biology and Head of the National Spatial Proteomics facility at Science for Life Laboratory)</p><p>Charlotte Stadler is the co-director of the Spatial Biology platform and Head of the National Spatial Proteomics facility at Science for Life Laboratory. She is also a Principal Investigator at the Royal Institute of Technology. She received her Ph.D. in 2012 within the framework of the Human Protein Atlas (HPA) project, with Prof. Emma Lundberg and Prof. Mathias Uhlén as her supervisors. During her PhD she established many of the protocols and pipelines for image based subcellular protein profiling that are used in the Human Protein Cell Atlas. Today, her main focus is to develop and implement services and technologies within spatial biology that can be used projects ranging from discovery to translational and clinical research. In her role she works with many companies in the spatial omics field including Thermo Fisher Scientific. Her internal research projects focus on the implementation and adaptation of multiplexed imaging solutions into clinical practice but also on integrating different omics types for a more complete molecular understanding of the tissue sample biology.&nbsp;</p></blockquote><blockquote><p><strong>Presenter: </strong>Adyary Fallarero, PhD, MBA (Sr. Manager, Thermo Fisher Scientific, Faculty of Pharmacy, University of Helsinki, Finland)</p><p>Dr. Fallarero earned PhD in Biochemistry from the University of Havana, Cuba and a Master in International Business Management (MBA) from the Tampere University of Applied Sciences, in Finland.</p><p>During her more than 10 years of academic career, she published over 75 peer-reviewed publications, co-authored over 10 patents, and was awarded multiple grants to lead research programs focused on early drug discovery of anti-biofilms. In 2018, she received the prestigious Oskar Öflund’s Foundation Grand Prize, for her contributions to the development of the field of bacterial biofilms in Finland.</p><p>She joined Thermo Fisher Scientific in 2016 to work on cell analysis instrumentation, gaining significant expertise in new product development and product management. Since 2021, she has been responsible for new product introductions, portfolio management and commercial enablement of cell and tissue imaging systems.</p></blockquote>

Thermo Fisher Scientific: Spatial Proteomics for Translational Research

Spatial Proteomics for Translational Research

Scale spatial proteomics from discovery to translation. Learn how Thermo Fisher's EVOS S1000 & Aluora kits reduce sample costs for tumor imaging

Spatial Proteomics in Translation: EVOS S1000 Imaging

<p><strong>This webinar provides a foundational overview of LC method optimization. The session will focus on parameters that are significant for method optimization, including column dimensions, sample loading, particle morphologies, silica specifications, and stationary phase selectivities. Attendees will gain insight into how to use method development tools for scalability, throughput, and reproducibility for their LC methods.</strong></p><h4><strong>Key Learning Points</strong></h4><ul><li>Understand your column, from hardware design through stationary phase.</li><li>Learn how to choose the right particle morphology to match your analytical objectives.</li><li>Master sample load scaling for consistent, reliable results.</li><li>Apply LC method scaling parameters to maximize throughput while maintaining reproducibility.</li></ul><h4><strong>Who Should Attend</strong></h4><ul><li>Any scientists and professionals working with liquid chromatography who want to learn about LC method optimisation during scaling for high throughput and preparative applications.</li></ul><h4><strong>One webinar, two viewing options</strong></h4><p>We know you're busy, select a viewing session that works best for you.</p><h5><strong>Viewing Options</strong></h5><p><strong>Session 1: Tuesday, September 1, 2026</strong></p><ul><li>Los Angeles: 10:00 AM PT&nbsp;</li><li>New York: 1:00 PM EST</li><li>Mexico City: 12:00 PM CDT</li></ul><p><strong>Session 2:Wednesday, September 2, 2026</strong></p><ul><li>London: 9:00 AM BST&nbsp;</li><li>Berlin: 10:00 AM CEST&nbsp;</li><li>Mumbai: 1:30 PM IST</li></ul><blockquote><p><strong>Speaker:</strong> Namrata Saxena (Technical Manager, Phenomenex)</p><p>&nbsp;Namrata Saxena is the Technical Manager for the Asia-Pacific region at Phenomenex and is part of the global technical team, she provides expert support for a wide range of chromatographic challenges particularly in the characterization of biotherapeutics and emerging cell and gene therapy modalities. Her role includes delivering technical training, hosting seminars and webinars, and contributing to scientific content development. Prior to joining Phenomenex, Namrata worked as a Product Specialist at Bischoff Chromatography GmbH in Germany where she gained extensive experience in stationary phase chemistry, column manufacturing and method development domains.&nbsp;</p></blockquote>

Phenomenex: Addressing LC Method Optimization - Scaling For Efficiency, Throughput And Reproducibility

Addressing LC Method Optimization - Scaling For Efficiency, Throughput And Reproducibility

Optimize and scale LC methods with confidence. Learn how column dimensions, particle morphology, and sample load impact throughput and reproducibility

LC Method Optimization: Scaling for High-Throughput Labs

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Top-down mass spectrometry enables a proteoform-first approach by keeping the protein molecule intact, combining intact mass information with intact-ion fragmentation to support confident characterization of sequences, modifications, variants, and proteoforms. In this webinar, you will see how Thermo Scientific Proteoform Studio brings acquisition, analysis, visualization, and reporting together in a streamlined workflow for intact mass and top-down applications.</strong></p><h5><strong>By attending this webinar, you will learn how to:</strong></h5><ul><li><strong>Understand how top-down MS supports proteoform-first characterization:</strong> See how intact mass and intact-ion fragmentation can be used to characterize proteoforms, modifications, variants, and sequence coverage.</li><li><strong>See how Proteoform Studio simplifies acquisition, analysis, and reporting: </strong>Learn how integrated instrument control, interactive deconvolution, targeted top-down method creation, database management, result review, and automated reports can reduce workflow complexity.</li><li><strong>Learn how Direct Mass Technology™ and automated workflows can improve data quality and productivity: </strong>Explore how Direct Mass Technology™, automated charge assignment, data aggregation, and proteoform tracks can help improve sequence coverage, simplify comparison, and support deeper characterization.</li></ul><h5><strong>Topics covered:</strong></h5><ul><li>Why top-down mass spectrometry matters</li><li>Proteoform Studio for intact protein characterization</li><li>Interactive deconvolution and walk-up analysis</li><li>Mixed and sliding-window deconvolution</li><li>Targeted top-down method creation</li><li>Direct Mass Technology™ workflows</li><li>Proteoform tracks and data aggregation</li><li>Automated reporting</li></ul><p>You will leave with a practical understanding of how Proteoform Studio can help streamline intact mass and top-down workflows for applications such as biotherapeutic characterization, antibody analysis, covalent binder localization, native MS, and deep proteoform sequencing.</p><h5><strong>This webinar is designed for scientists working in:</strong></h5><ul><li>Intact protein analysis</li><li>Top-down proteomics</li><li>Native MS</li><li>Biotherapeutic characterization</li><li>Proteoform analysis</li><li>Protein complex or antibody characterization</li><li>Mass spectrometry core facilities supporting intact protein workflows</li></ul><p>If you are unable to attend the live webinar, please register to automatically receive a link to the on-demand recording.</p><blockquote><p><strong>Presenter: </strong>Jacob McCabe (Product Manager, Proteinaceous- Thermo Fisher Scientific)</p><p>Jacob McCabe, Ph.D., is a life-science innovator specializing in mass spectrometry, high-throughput automation, and software engineering who currently serves as a Product Manager at Thermo Fisher Scientific following the acquisition of Proteinaceous in March 2026. With a focus on translating complex research into scalable, user-centric digital solutions, he leads cross-functional teams to bridge laboratory instrumentation with automated workflows</p></blockquote></div></div></div>

Thermo Fisher Scientific: ASMS 2025 Workshops

Proteoform Studio software, top down made simple

Simplify top-down MS with Thermo Scientific Proteoform Studio. Learn how automated deconvolution and Direct Mass Technology™ analyze intact proteoforms

Proteoform Studio: Top-Down MS & Intact Protein Analysis

<p><strong>Achieving comprehensive antibody-drug conjugate (ADC) characterization no longer requires complex multi-step workflows. Advances in native LC-MS are creating new opportunities to simplify ADC analysis while maintaining the depth of information needed to support development decisions.</strong></p><p>In this SelectScience® TechTalk, Roxana Eggleston-Rangel, Senior Applications Scientist at Phenomenex, will showcase how Biozen® Native RP-1 and RP-5 columns enable direct drug-to-antibody ratio (DAR) analysis through a streamlined, MS-compatible native reverse-phase liquid chromatography-mass spectrometry (RP-LC-MS) workflow.</p><p>Learn how this approach supports DAR determination, proteoform characterization, and positional isomer resolution without fraction collection or buffer exchange while maintaining native conditions.</p><p>Using case studies featuring the approved ADC therapies Enhertu®, Padcev®, Polivy®, and Adcetris®, Eggleston-Rangel will demonstrate how this workflow can be applied across a range of ADC modalities and payload chemistries. In just 20 minutes, discover how the same approach can support both high-resolution mass spectrometry and routine UV-based DAR monitoring, bringing greater efficiency and confidence to ADC characterization.</p><h5><strong>Certificate of attendance</strong></h5><p>If you attend the live TechTalk, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes. If you view the on-demand TechTalk, you can request a certificate of attendance by emailing editor@selectscience.net.</p><h5><strong>TechTalk details</strong></h5><ul><li>Cost: Free to attend</li><li>Location: Online</li><li>Duration: 20 minutes</li></ul><p>Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on-demand recording once it becomes available.</p><h5><strong>Who should attend?</strong></h5><p><strong>This event is perfect for:</strong></p><ul><li>Pharmaceutical and biopharmaceutical characterization scientists</li><li>Analytical development managers and directors overseeing LC-MS workflows</li><li>Researchers developing methods for ADC characterization, drug-to-antibody ratio (DAR) analysis, and isomer identification</li></ul><h5><strong>What will this webinar cover?</strong></h5><ul><li>How native RP chromatography can be used for streamlined ADC DAR characterization and intact mass analysis.</li><li>Best practices for selecting Biozen® Native RP columns based on ADC properties and analytical goals.</li><li>How a single workflow can provide DAR determination, proteoform characterization, and positional isomer information.</li><li>Real-world examples demonstrating how native RP-LC-MS can improve efficiency while reducing sample preparation complexity.</li></ul><h5><strong>Join the TechTalk to get answers to these questions:</strong></h5><ul><li>How can native RP-LC-MS simplify comprehensive ADC characterization workflows?</li><li>How do Biozen® Native RP-1 and RP-5 columns enable direct intact ADC analysis?</li><li>How is drug-to-antibody ratio (DAR) accurately determined under native conditions?</li><li>How can native RP-LC-MS resolve proteoforms and positional isomers in ADCs?</li><li>What insights were gained from case studies on Enhertu®, Padcev®, Polivy®, and Adcetris®?</li></ul><blockquote><p><strong>Speaker:</strong> Roxana Eggleston-Rangel (Senior Application Scientist, Phenomenex)</p><p>Roxana Eggleston-Rangel is a Senior Applications Scientist specializing in biopharmaceutical characterization workflows, with expertise in LC-MS, native chromatography, antibody-drug conjugates (ADCs), monoclonal antibodies, and protein biotherapeutics. She develops and evaluates analytical methods for critical quality attributes, including drug-to-antibody ratio (DAR), oxidation, isomerization, glycation, and fragmentation. Her work focuses on advancing innovative chromatographic and mass spectrometry solutions, generating application data, technical publications, and scientific content that help researchers improve characterization of complex biologics and next-generation therapeutics.</p></blockquote>

Phenomenex: TechTalk - ADC characterization in one native LC-MS workflow

ADC characterization in one native LC-MS workflow

Simplify ADC characterization with Phenomenex Biozen® Native RP columns. Learn direct DAR determination and proteoform profiling in one LC-MS workflow

Native LC-MS ADC Characterization: Phenomenex Biozen Columns

<h3><strong>Standardize. Automate. Simplify.</strong></h3><h4><strong>Endotoxin Testing for Modern QC Labs</strong></h4><p><strong>Endotoxin testing is a critical quality control requirement in pharmaceutical manufacturing, where laboratories must consistently balance efficiency, data integrity, and regulatory compliance. Manual workflows can be time-consuming and introduce variability that impacts reproducibility and documentation. The combination of the Waters Andrew+™ Robot and ENDOZYME® II GO from bioMérieux provides a standardized and automated approach to endotoxin testing that helps reduce manual handling, improve consistency, and support audit-ready laboratory operations.</strong></p><p>In this joint webinar, experts from Waters Corporation and bioMérieux will demonstrate how automation can help QC laboratories streamline sample preparation, improve method execution, and establish greater traceability throughout the testing process. You'll learn how OneLab™ Software captures and documents workflow execution with audit trails and electronic records while ENDOZYME II GO simplifies assay preparation through its ready-to-use format, enabling more reliable and reproducible endotoxin testing.</p><p>Whether your goal is to increase throughput, reduce operator-to-operator variability, or strengthen compliance readiness, this session will showcase a practical automation solution designed for today's regulated laboratory environment.</p><h4><strong>What you’ll take away</strong></h4><ul><li>How to standardize and automate endotoxin testing workflows using the Andrew+ Robot and ENDOZYME® II GO to reduce manual handling, improve reproducibility, and increase laboratory efficiency.</li><li>How automation strengthens traceability and data integrity through standardized protocol execution, electronic workflow documentation, and audit-ready records that support regulated QC environments.</li><li>How QC laboratories can improve compliance readiness and operational performance while reducing operator variability and scaling endotoxin testing with greater confidence.</li></ul><h4><strong>This webinar is designed for you if you want to:</strong></h4><ul><li>Streamline endotoxin testing through automation</li><li>Improve laboratory efficiency and consistency</li><li>Reduce manual steps and enhance compliance</li><li>Learn about the latest automation solutions for endotoxin testing</li></ul><p>Don't miss it!</p><blockquote><p><strong>Speaker:&nbsp;</strong>Guillaume Mignard (Lab Automation Product Marketing Manager, Waters Corporation)</p><p>Guillaume Mignard serves as the Lab Automation Product Manager at Waters Corporation, a position he has held since 2025. He previously occupied the roles of Product Manager and Product Designer of the OneLab™ Software.</p><p>Since his start at Waters in 2017, he has led the strategic vision, design, and deployment of the OneLab™ Software, a cloud-based platform that democratizes laboratory automation for scientists worldwide.</p><p>Guillaume initiated his professional journey as a UX/UI designer specializing in business software, where he pioneered user-centric design principles at a time when such approaches were still emerging beyond web marketing.</p></blockquote><blockquote><p><strong>Speaker:&nbsp;</strong>Paola Vigilanza, PhD (Global Solution Manager, bioMérieux)</p><p>Paola Vigilanza, PhD in Cellular and Molecular Biology, works as Global Solution Manager for Pyrogen Testing at bioMérieux.</p><p>Her background includes long-standing experience in R&amp;D and pharmaceutical industry, with a focus on endotoxin testing and product management.</p></blockquote><blockquote><p><strong>Speaker:&nbsp;</strong>Luca Di Bello (Application Specialist, bioMérieux)</p><p>Luca Di Bello holds a MSc in Biology from the Technical University of Munich, Germany.</p><p>In his current role as Application Specialist at bioMérieux he supports and develops current and new applications of the ENDONEXT™ endotoxin assays and automation platforms.</p></blockquote>

Waters Corporation: Streamlining Endotoxin Testing: Automated Sample Preparation and Audit-Ready Workflows for QC Laboratories

Streamlining Endotoxin Testing: Automated Sample Preparation and Audit-Ready Workflows for QC Laboratories

Automate endotoxin testing with Waters Andrew+ Robot and bioMérieux ENDOZYME II GO. Streamline QC workflows, reduce errors, and ensure audit-ready compliance

Automated Endotoxin Testing: Waters Andrew+ & ENDOZYME GO

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Join our experts for an in-depth look at the new Thermo Scientific™ Orbitrap™ Excedion™ Hybrid Mass Spectrometer—a next-generation HRAM platform designed to help laboratories confidently tackle today's analytical challenges while remaining ready for tomorrow's discoveries.</strong></p><p>Whether you're working in metabolomics, drug metabolism, environmental and food safety research, proteomics, or bioanalysis, the Orbitrap Excedion MS delivers the sensitivity, dynamic range, and robustness needed to detect more low-abundance compounds, improve confidence in your results, and maximize productivity. Learn how Full Scan Enhanced Dynamic Range (eDR) technology enables deeper sample coverage by revealing low-level analytes that conventional full-scan methods may miss, while maintaining outstanding quantitative performance.</p><p>This session will also explore how the Orbitrap Excedion platform is purpose-built for long-term value. With in-lab upgrade paths to the Orbitrap Excedion Pro MS, laboratories can expand capabilities as research needs evolve—protecting their investment without replacing their instrument. You'll also discover how a redesigned front-end, robust ion source, and simplified maintenance contribute to reliable, reproducible performance and greater uptime for busy laboratories.</p><p>Bring your questions and hear directly from our product experts about the innovations that are helping researchers generate more confident results today while preparing for the analytical challenges of tomorrow.</p><h4><strong>Who should attend?</strong></h4><ul><li>Scientists and laboratory managers seeking greater sensitivity, dynamic range, and confidence in HRAM mass spectrometry workflows.</li><li>Researchers working in metabolomics, DMPK, environmental and food safety, proteomics, bioanalysis, or other complex small-molecule applications.</li><li>Existing Orbitrap users and laboratories planning future instrument investments who want to understand the benefits of a scalable, upgradeable platform.</li></ul><h4><strong>What you can expect to learn</strong></h4><ul><li>How Full Scan Enhanced Dynamic Range (eDR) technology improves detection of low-abundance compounds and expands analytical coverage in complex samples.</li><li>How the Orbitrap Excedion MS delivers robust, reproducible performance with improved uptime, simplified operation, and reliable quantitative results.</li><li>How the platform's in-lab upgrade path enables your laboratory to add new capabilities as your research evolves, protecting your investment and future-proofing your workflows.</li></ul><blockquote><p><strong>Presenter: </strong>Maciej Bromirski (Sr. Product Marketing Manager, Thermo Fisher Scientific)</p><p>Maciej Bromirski has over 25 years of experience in mass spectrometry starting as an undergraduate student with late Prof. Ken Standing at the Physics Department at University of Manitoba in Winnipeg, Canada. Upon completion of his graduate studies on IR &amp; UV vacuum MALDI Q-TOF prototype MS with first oral presentation at ASMS and publications starting in 1999, Maciej undertook various roles and responsibilities with different Mass Spectrometry vendors. Since 2010 to present-day, Maciej has been fully dedicated to new product introductions and marketing developments of Q Exactive series, Orbitrap Exploris and more recently Orbitrap Excedion series MS with Thermo Fisher Scientific.</p><p><strong>Presenter: </strong>Claire Dauly (Senior Product Manager, Thermo Fisher Scientific)</p></blockquote></div></div></div>

Thermo Fisher Scientific: Ask the Expert: What to expect from the new Thermo Scientific™ Orbitrap™ Excedion™ Hybrid mass spectrometers

Ask the Expert: What to expect from the new Thermo Scientific™ Orbitrap™ Excedion™ Hybrid mass spectrometers

Explore the Orbitrap Excedion MS, featuring enhanced dynamic range, robust HRAM performance and an upgrade path to the Excedion Pro platform.