The KNAUER AZURA HTQC UHPLC (1240 bar) is a high-performance UHPLC system designed for high-throughput quality control (QC) where speed, robustness, and reproducibility are essential.
The system features a unique concept of parallel analysis and offline column re-equilibration, significantly increasing productivity. With two gradient pumps, one column performs the analytical run while the second is re-equilibrated in backflush mode.
This architecture enables:
- ≥30% reduction in cycle time
- increased sample throughput
- column protection from matrix contamination
- consistent retention times
It is ideal for pharmaceutical QC laboratories requiring automation and validated workflows.
Key Features
- UHPLC system up to 1240 bar (124 MPa)
- Dual gradient pumps (HPG + LPG)
- Parallel analysis and column re-equilibration
- Backflush mode for column protection
- ≥30% faster analysis cycles
- High flow reproducibility
- Autosampler with cooling
- Column thermostat (Peltier)
- Fully automated modular system
- MS detector compatibility
System Configuration
Included components:
- Eluent tray E 2.1L
- Pump P 8.1L (HPG)
- Pump P 6.1L (LPG)
- Liquid handler LH 8.1 + Robotic Cooler
- Column thermostat CT 2.1
- Column switching & backflush valve
- Accessories and tools
Technical Specifications
Pumps
P 8.1L (HPG – analytical pump):
- Max pressure: 1240 bar
- Flow rate: up to 5 mL/min
- Adaptive pulsation compensation
- Degasser + binary solvent selection
- Low baseline noise
P 6.1L (LPG – re-equilibration):
- Quaternary gradient
- Integrated degasser
- Low dwell volume
- Inline filter
Autosampler
LH 8.1:
- XYZ autosampler
- Capacity: up to 390 samples
- Temperature: 4–40 °C
- Low carryover
Column Thermostat
CT 2.1:
- Peltier controlled
- Above and below ambient operation
- High precision
Valve System
- Column switching + backflush
- Up to 1200 bar
- Parallel column operation
Detection
- Compatible with all HPLC detectors
- Ideal for LC-MS coupling
HTQC Concept
- Independent flow paths (analysis vs re-equilibration)
- Backflush re-equilibration
- Parallel operation
- Increased throughput without compromise
Typical Applications
- Pharmaceutical QC
- Routine validated workflows
- High sample throughput environments
- Reversed-phase HPLC
