ISC 2026 - Day 2

<h4>What if you could compress 179 days of grueling laboratory workflow into just 14 hours?</h4>In this episode of ‪ChromatographyTalk‬, ‪Organomation‬ General Manager David Oliva sits down with analytical chemist Laura Penabad to discuss her groundbreaking new research in biocatalysis and high-throughput screening. Evolving engineered enzymes typically requires checking thousands of variants—a massive bottleneck when traditional Liquid Chromatography-Mass Spectrometry (LC-MS) runs take minutes per sample. Laura reveals how her team built a modular screening platform that shatters this limitation, running samples 128 times faster than standard methods without sacrificing analytical accuracy.Laura breaks down the "orchestra" of technologies making this possible, including coupling nanoliter droplet microfluidics with Cyclic Ion Mobility-Mass Spectrometry (cIM-MS) to separate complex chemical isomers in milliseconds. She also shares the chaotic but triumphant behind-the-scenes stories of her PhD journey—from presenting a "comically bad" early poster at ASMS to recruiting an undergraduate mechanical engineer to build custom automation software from scratch.If you are an early-career researcher, a mass spec enthusiast, or curious about the future of synthetic biology and machine learning in chemistry, this episode is packed with invaluable intuition and advice.<h3>Video Transcription</h3><h4>From Months to Hours: Droplet Ion Mobility–MS for Biocatalysis Screening</h4>High-throughput screening is central to directed enzyme evolution, but conventional analytical workflows can create a difficult compromise: extremely fast screens often provide limited structural information, while techniques such as LC-MS offer much richer chemical insight at the cost of throughput. In a recent interview, analytical chemist Laura described how her work with droplet-based cyclic ion mobility mass spectrometry is helping bridge that gap—providing rapid analysis while retaining the ability to distinguish structurally similar products.Her research grew from an initially modest proof of concept into a screening platform capable of analyzing a 96-well plate in roughly ten minutes. The resulting workflow was approximately 128 times faster than a conventional three-minute LC-MS analysis, opening new possibilities for directed evolution campaigns in which thousands of enzyme variants need to be evaluated.<h4>Directed evolution needs better analytical screening</h4>Biocatalysis takes advantage of enzymes as highly selective catalysts capable of performing reactions under relatively mild conditions. Directed evolution extends those capabilities by deliberately modifying enzyme sequences, expressing large numbers of variants, screening their activity, and using the best-performing mutants as starting points for subsequent rounds of evolution.The process can be repeated multiple times, progressively steering an enzyme toward improved activity, altered substrate specificity, or even chemistry that does not occur naturally.But the effectiveness of directed evolution depends heavily on the screening step. The more variants that can be analyzed—and the more useful chemical information that can be collected for each one—the more effectively researchers can explore the enormous sequence space available to an enzyme.For Laura, this created a clear analytical challenge: develop a screening platform that was substantially faster than conventional chromatographic analysis without sacrificing the structural discrimination needed for chemically similar products.<h4>From an imperfect first experiment to a working platform</h4>The project did not begin with a polished high-throughput workflow.Laura recalled looking back at her 2023 ASMS poster, where the early system was still working with standards rather than true isomeric samples. Droplet introduction was slow—around six seconds per droplet—and the signals were far from the ideal reproducible, square, flat-topped profiles expected from replicate droplets.Nevertheless, simply producing a droplet signal represented an important first milestone.The decisive change came when the project stopped being treated merely as a demonstration that droplet ion mobility–MS could work and instead became a deliberate effort to build a robust screening platform.Laura approached the problem in modules. First came reliable droplet introduction. Then the ion mobility separation method. Quantification became another independent component. Matrix effects were introduced later, gradually making the system resemble the conditions expected with real screening samples.Each layer was tested before another was added.This stepwise strategy became one of the central principles of the project: rather than attempting to optimize the entire system simultaneously, individual components were developed, challenged, and then assembled into an increasingly realistic workflow.<h4>Finding the middle ground between speed and structural information</h4>One of the biggest analytical problems in high-throughput screening is distinguishing products with the same nominal or exact mass.Constitutional isomers may contain the same atoms and therefore generate the same mass-to-charge ratio, while differing only in how functional groups are arranged within the molecular structure. Very rapid optical or mass-based screens may therefore struggle to distinguish them.Traditional LC-MS can solve many of these problems through chromatographic separation, but a several-minute analysis rapidly becomes impractical when thousands of enzyme variants must be screened.Ion mobility offered Laura’s team another option.Rather than separating compounds on a chromatographic timescale, ion mobility can differentiate ions according to their gas-phase behavior on a much shorter timescale. In the workflow described in the interview, this created a useful compromise: not the kilohertz throughput possible with some simple screening technologies, but dramatically faster structural differentiation than conventional LC-MS.The goal was therefore not simply to achieve the fastest possible screen, but to find a middle-throughput analytical regime with enough resolving power to answer chemically meaningful questions.<h4>A 96-well plate in about ten minutes</h4>That strategy eventually produced one of the most striking results of the project.The droplet cyclic ion mobility–MS platform processed a 96-well plate in roughly ten minutes, while maintaining quantitative results comparable with the conventional LC-MS workflow used for comparison. According to the interview, this represented an approximately 128-fold increase in analysis speed relative to a three-minute LC-MS run.Laura described the successful plate experiment less as a surprise than as confirmation that the modular development strategy had worked.Before reaching that point, the workflow had already been challenged through a sequence of increasingly demanding experiments: droplet formation, ion mobility separation, calibration, matrix-containing calibration, and cross-testing analytes at different concentrations. By the time the complete plate was analyzed, each individual part of the analytical system had already been tested under progressively more realistic conditions.<h4>What does that speed mean for directed evolution?</h4>The impact becomes even clearer when the workflow is considered at the scale of an entire directed-evolution campaign.Laura’s manuscript estimated that a five-round campaign involving 5,000 variants would require approximately 179 days using the conventional LC-MS workflow but only about 14 hours using the new platform.Compressing months of analytical work into less than a day has consequences beyond laboratory productivity.It allows researchers to screen more enzyme variants and therefore sample a larger portion of sequence space. But the resulting datasets may also become increasingly valuable for computational approaches.Rather than retaining information only about the best-performing enzyme variant, researchers can preserve data describing variants that performed poorly as well as those that succeeded. When genotype and phenotype information remain linked through the well-plate workflow, these larger datasets can potentially provide richer input for machine-learning models designed to guide subsequent rounds of enzyme evolution.Faster analysis therefore does more than accelerate an existing experiment—it can change the scale and design of the experiment itself.<h4>Balancing ion mobility resolution and signal</h4>Increasing cyclic ion mobility separation time can improve resolution, but it also introduces an important trade-off: additional passes can reduce signal.Laura optimized this balance experimentally by continuously infusing mixtures containing both isomers and progressively adjusting the ion mobility conditions. After tuning parameters such as wave height and velocity, increasing the separation to three passes provided baseline resolution at the high analyte concentrations used during method development.<blockquote>Concentration, however, also mattered.</blockquote>At higher ion populations, space-charge effects could broaden peaks and reduce the baseline separation. This meant that the optimal number of passes could not be selected independently of the concentration range required by the final assay.Her broader advice for optimization is therefore application-driven: decide first what the analytical method actually needs to accomplish.More speed will almost always require sacrificing something—resolution, signal intensity, quantitative precision, or another performance parameter. The key is to identify which compromise the application can tolerate and then optimize the system around that requirement.<h4>Solving droplet carryover with a practical compromise</h4>Droplet-based workflows present their own engineering challenges, including carryover between neighboring samples.In Laura’s system, analytes showed little tendency to partition into the fluorinated oil separating aqueous droplets within the Teflon tubing. The more troublesome carryover occurred closer to electrospray ionization, where a small amount of sample could remain associated with the interface and appear when the next droplet arrived.Rather than adding excessive engineering complexity to an already elaborate platform, the researchers adopted a pragmatic solution: a sacrificial wash droplet between analytical samples.It is an example of a recurring theme throughout the project. The objective was not to construct the theoretically most sophisticated droplet system, but to create a screening workflow that remained sufficiently robust, reproducible, and practical for large numbers of samples.<h4>High-throughput analysis also requires high-throughput data processing</h4>Accelerating the mass spectrometry experiment created another bottleneck: the data.The instrument produced a continuous intensity-versus-time trace rather than a neatly organized well-plate dataset. With small experiments, Laura could manually identify individual droplets and process the results in spreadsheets. That approach quickly became unrealistic as sample numbers increased.The solution emerged through collaboration with an undergraduate mentee, Aiden, who helped develop a dedicated software tool for processing the continuous traces.Laura defined how the software should behave and how the analytical information should be organized, while Aiden developed the computational implementation. The workflow itself was subsequently adjusted to make automated data processing more reliable—for example, by introducing marker columns that allowed the software to recognize the end of each plate row.The resulting tool can accept the acquired traces together with information about plate dimensions and replicates and automatically return parameters including peak identity, duration, and the corresponding well position. A later version also generated an automatically populated heat map.The experience illustrates how improving analytical throughput often requires simultaneous development of instrumentation, experimental design, and informatics. Making the measurement faster is useful only if the resulting data can be processed at a comparable speed.<h4>Mentoring became part of the scientific process</h4>The software project also reflects another theme Laura emphasized throughout the interview: the value of mentoring.Several younger researchers contributed directly to the development of the final platform. Laura described mentees not simply as additional hands in the laboratory but as scientists capable of proposing their own hypotheses and experimental ideas.Working with undergraduate researchers also influenced the way she organized experiments.Because their available laboratory time was limited, each task needed to have a clear purpose. That encouraged a more disciplined approach to experimental planning: instead of performing experiments simply because they could be done, the team had to ask which experiment would most efficiently answer the next important question.In that sense, mentoring became another mechanism for improving the research itself.<h4>The next step: continuous, automated screening</h4>Despite the dramatic increase in analytical speed, the current workflow still includes manual operations such as loading tubing and connecting the sample stream to the mass spectrometer.The next engineering challenge is therefore automation.Laura described ongoing work using the Venturi effect to pull samples directly from wells into the droplet system. Building on previous work in the laboratory with 96-well plates, she has already tested this approach with as many as 2,000 samples.The long-term direction is clear: continuous and robust droplet generation, automated handling of thousands of samples, rapid ion mobility separation, mass spectrometric detection, and automated reconstruction of the resulting data into plate-based outputs.Combining those elements could move the system closer to the type of large-scale screening required for increasingly ambitious biocatalysis campaigns.<h4>Learning mass spectrometry one problem at a time</h4>Laura also reflected on the broader experience of developing the platform during her PhD.Ion mobility and mass spectrometry initially appeared intimidating, particularly because they combine concepts from analytical chemistry, physical chemistry, separations, instrumentation, and electrical engineering. What eventually changed was not simply learning more facts, but developing the ability to move repeatedly between theory and experiment.An unexpected result sends the researcher back to the underlying theory. A better understanding suggests a modified experiment. That experiment creates another observation, gradually building intuition about how the system behaves.Her advice to early-career scientists is therefore to accept that this process takes time.Advanced analytical techniques may initially appear overwhelming, but understanding develops incrementally through repeated interaction between theory, experimentation, failure, and refinement. Equally important, she emphasized the role of the supportive ion mobility–mass spectrometry community in making a technically demanding field more approachable for young researchers.From the first inconsistent droplets to a platform capable of processing thousands of samples, that iterative mindset ultimately shaped the entire project.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote><blockquote><h4>Concentrating on Chromatography Podcast</h4>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!You can find Concentrating on Chromatography Podcast in podcast apps:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185">Apple podcast</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography">podscan</a></li></ul>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos">YouTube channel</a></blockquote>

Droplet Cyclic Ion Mobility Mass Spec: Compressing Months of Enzyme Screening Into Just 14 Hours

ISC 2026 - Day 3

Article

Events

Video

Scientists

Interview

The International Symposium on Chromatography (ISC) represents the oldest conference series focussing on separation science. ISC symposia have been organised since 1956 in each even year. ISC is internationally recognised as one of the premier meeting series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.

International Symposium on Chromatography - (ISC)

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Organomation RapidVap N2 Nitrogen Evaporator

The RapidVap N₂ nitrogen evaporator enables fast solvent evaporation using a controlled nitrogen stream. It combines dry block heating, vortex motion, and end-point detection for efficient sample concentration.

The RapidVap N₂ Evaporation Systems provide a fast, automated alternative to <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1904">Kuderna-Danish</a> and rotary evaporators, compatible with a wide range of aggressive chemicals. By directing a controlled stream of nitrogen or dry gas onto the sample surface, these systems reduce the partial pressure above the liquid to accelerate evaporation, with optional vortex motion and dry heat for further speed.&nbsp;The main block accommodates eight large samples up to 450 mL each, and an accessory block supports eight 170 mL tubes for solid phase extraction.&nbsp;The unique Cool-Zone block design slows evaporation after the end point, preventing samples from going completely dry and allowing time for solvent exchange or removal. Built-in alarms notify users when the process reaches the timed end point or approaches completion, enabling unattended operation.&nbsp;<ul><li>Dry Block: Dry heating system prevents potential contamination source</li><li>Increased Surface Area: Vortex motion increases surface area for faster evaporation</li><li>PTFE-Coated Chamber: Aluminum with PTFE coating for broad range of chemical compatibility</li><li>End-Point Detection: Signal completion of run allows samples to be left unattended while drying to desired end point</li></ul>In partnership with Labconco.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_Rapid_Vap_N2_Nitrogen_Evaporator_2_eb75d729d4.jpg" alt="Organomation RapidVap N2 Nitrogen Evaporator " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_Rapid_Vap_N2_Nitrogen_Evaporator_2_eb75d729d4.jpg 235w," sizes="100vw" width="1152" height="764"><h3>STANDARD FEATURES</h3><ul><li>Dry block heating system prevents adding potential contamination source</li><li>Vortex action, heat, and vacuum combine to accelerate evaporation</li><li>PTFE-coated chamber for broad range of chemical compatibility</li><li>Microprocessor-controlled vortex motion increases surface area for faster evaporation</li><li>Signal completion of run allows samples to be left unattended while evaporation to desired end point</li><li>Microprocessor-controlled nitrogen blow down manifold to facilitate liquid to gas phase change</li></ul><h3>REQUIREMENTS (not included):</h3><ul><li>Glassware</li><li>Nitrogen source with flow rate of 0.6 CFM/17 LPM minimu</li><li>Gas pressure regulator</li></ul><h3>OPTIONS</h3><ul><li>RS-232 Link for two-way communication (Cat# LC-7910010)</li></ul><h3>SPECIFICATIONS</h3><ul><li>Instrument: RapidVap N2</li><li>Instrument Catalog Number: LC-7910000</li><li>Bath Type: Dry aluminum blocks</li><li>Number of Sample Positions: Up to 8</li><li>Dimensions (w x d x h): 21.7 x 19.0 x 13.5 in</li><li>Weight: Net: 99 lbs. (45 kg)</li><li>Weight: Gross: 107 lbs. (49 kg)</li><li>Sample Layout: Circular</li><li>Lid Material: Glass</li><li>Pressure Regulator: 0–20 psi</li><li>Temperature Range: 0–100 °C</li><li>Warranty: 1 year</li><li>Electrical Requirements: 115V, 60 Hz</li><li>Vortex Motion: Up to 500 RPM</li></ul><h5>Nitrogen Requirements</h5><ul><li>Flow Rate: 0.6 CFM / 17 LPM minimum</li><li>Pressure: 5–10 psi</li></ul><h3>ACCESSORIES</h3><ul><li>PTFE-coated aluminum blocks</li><li>Borosilicate glass tubes</li><li>600 mL tubes with stems</li><li>170 mL tubes with stems</li><li>Flat bottom tubes</li><li>Eight-place stainless steel racks</li><li>Glassware caps</li></ul>

Organomation RapidVap N2/48 Nitrogen Evaporator

The RapidVap N₂/48 Nitrogen Evaporation System rapidly concentrates up to 48 samples using nitrogen blowdown, vortex motion, and dry block heating without the need for water baths.

The RapidVap N₂/48 Evaporation System combines nitrogen blowdown, vortex motion, and controlled heat to accelerate evaporation of up to 48 small samples or eight 450 mL samples simultaneously. A stream of nitrogen or dry gas reduces the partial pressure over the liquid, speeding solvent removal, while microprocessor-controlled vortex motion increases surface area and continuously mixes samples for maximum recovery.&nbsp;Nitrogen delivery can be applied to 2, 4, 6, or all 8 clusters of six ports, conserving gas when processing fewer samples. Using a dry block heating method, the RapidVap N₂/48 offers a reliable, low-maintenance alternative to water bath systems and is ideal for applications such as drug development, bioresearch, combinatorial chemistry, environmental testing, forensics, and toxicology.&nbsp;<ul><li>Dry Block: Dry heating system prevents potential contamination source</li><li>Increased Surface Area: Vortex motion increases surface area for faster evaporation</li><li>PTFE-Coated Chamber: Aluminum with PTFE coating for broad range of chemical compatibility</li><li>End-Point Detection: Signal completion of run allows samples to be left unattended while drying to desired end point</li></ul>In partnership with Labconco.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_Rapid_Vap_N2_48_Nitrogen_Evaporator_2_cc454a8f2d.jpg" alt="Organomation RapidVap N2_48 Nitrogen Evaporator" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_Rapid_Vap_N2_48_Nitrogen_Evaporator_2_cc454a8f2d.jpg 234w," sizes="100vw" width="1169" height="783"><h3>STANDARD FEATURES</h3><ul><li>Dry block heating system prevents adding potential contamination source</li><li>Vortex action, heat, and vacuum combine to accelerate evaporation</li><li>PTFE-coated chamber for broad range of chemical compatibility</li><li>Microprocessor-controlled vortex motion increases surface area for faster evaporation</li><li>Signal completion of run allows samples to be left unattended while evaporation to desired end point</li><li>Microprocessor-controlled nitrogen blow down manifold to facilitate liquid to gas phase change</li></ul><h3>REQUIREMENTS (not included)</h3><ul><li>Sample block</li><li>Glassware</li><li>Nitrogen source with flow rate of 3.5 CFM/100 LPM minimu</li><li>Gas pressure regulator</li></ul><h3>OPTIONS</h3><ul><li>RS-232 Link for two-way communication (Cat# LC-7910014)</li></ul><h3>SPECIFICATIONS</h3><ul><li>Instrument: RapidVap N2/48</li><li>Instrument Catalog Number: LC-7910012</li><li>Bath Type: Dry aluminum blocks</li><li>Number of Sample Positions: Up to 48</li><li>Dimensions (w x d x h): 21.7 x 19.0 x 13.5 in</li><li>Weight: Net: 92 lbs. (42 kg)</li><li>Weight: Gross: 100 lbs. (45 kg)</li><li>Sample Layout: Circular</li><li>Lid Material: Glass</li><li>Pressure Regulator: 0–20 psi</li><li>Temperature Range: 0–100 °C</li><li>Warranty: 1 year</li><li>Electrical Requirements: 115V, 60 Hz</li><li>Vortex Motion: Up to 500 RPM</li></ul><h5>Nitrogen Requirements</h5><ul><li>Flow Rate: 3,5 CFM / 100 LPM minimum</li><li>Pressure: 5–10 psi</li></ul><h3>ACCESSORIES</h3><ul><li>PTFE-coated aluminum blocks</li><li>Borosilicate glass tubes</li><li>600 mL tubes with stems</li><li>170 mL tubes with stems</li><li>Flat bottom tubes</li><li>Eight-place stainless steel racks</li><li>Glassware caps</li></ul>

Organomation RapidVap Vertex Dry Evaporator

The RapidVap Vertex dry evaporator accelerates solvent evaporation for up to 50 samples using dry block heating, gentle nitrogen blowdown, and an intuitive touchscreen interface.

The RapidVap Vertex Dry Evaporator accelerates sample evaporation by combining efficient dry heat with gentle nitrogen blowdown, allowing laboratories to process up to 50 samples simultaneously.Its intuitive touchpad interface makes it easy to set and control both temperature and run time, and users can save up to ten custom programs to ensure consistent, repeatable workflows. Because it relies on a dry block heater rather than a traditional water bath, the system requires minimal upkeep—no distilled water, additives, or concerns about waterborne contamination.The RapidVap Vertex is well-suited for a wide range of sample prep needs, including pharmaceutical and drug development, clinical laboratories, environmental analysis, agricultural chemistry, and forensic testing.&nbsp;<ul><li>LCD Display: Touchscreen programming shows parameters for block, sample, and time</li><li>Nitrogen Control: Each switch controls nitrogen flow to each row of five nozzles</li><li>Temperature Sensor: Monitors block or sample temperature</li><li>Dry heat - no water bath: Less maintenance, no rust, no condensation, and no potential source of cross contamination</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Organomation_Rapid_Vap_Vertex_Dry_Evaporator_2_c112725d7a.jpg" alt="Organomation RapidVap Vertex Dry Evaporator" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Organomation_Rapid_Vap_Vertex_Dry_Evaporator_2_c112725d7a.jpg 245w," sizes="100vw" width="1375" height="768">In partnership with Labconco.<h3>STANDARD FEATURES</h3><ul><li>LCD display with touchscreen programming</li><li>Nitrogen control to each row of nozzles</li><li>Pressure regulator for 0 to 45 psi</li><li>Dry heat for less maintenance and no rust compared to water baths</li><li>Microprocessor-controlled heater up to 100 °C</li><li>Temperature sensor monitors block or sample temperature</li><li>Angled samples to increase surface area for faster evaporation</li></ul><h3>REQUIREMENTS (not included)</h3><ul><li>Aluminum block (Specific cat # depends on your tube size)</li><li>Sample tubes</li><li>Nitrogen source with a flow rate of 6.5 CFM/185 LPM minimum</li></ul><h3>SPECIFICATIONS</h3><ul><li>Instrument Catalog Number: LC-7320020</li><li>Bath Type: Dry aluminum blocks</li><li>Number of Sample Positions: Up to 50</li><li>Dimensions (w x d x h): 20.4 x 13.0 x 12.5 in</li><li>Weight: Net: 35 lbs. (16 kg)</li><li>Weight: Gross: 45 lbs. (20 kg)</li><li>Sample Layout: 5 rows of 10 samples</li><li>Lid Material: Glass</li><li>Pressure Regulator: 0–45 psi</li><li>Temperature Range: 30–100 °C</li><li>Warranty: 1 year</li><li>Electrical Requirements: 115V, 60 Hz</li></ul><h5>Nitrogen Requirements</h5><ul><li>Flow Rate: 6.5 CFM / 185 LPM minimum</li><li>Pressure: &lt;50 psi</li></ul><h3>ACCESSORIES</h3><ul><li>Aluminum blocks</li></ul>

Thermo Scientific TSQ Altis Plus EFOX Edition Triple Quadrupole Mass Spectrometer

Thermo Scientific TSQ Altis Plus EFOX Edition is a triple quadrupole mass spectrometer designed for ultra-sensitive quantification of trace contaminants in environmental and food safety analyses.

The Thermo Scientific™ TSQ Altis™ Plus EFOX Edition is a triple quadrupole mass spectrometer engineered for the most demanding environmental and food safety applications. Combining extreme sensitivity, high acquisition speed, and robust system design, it enables accurate detection and quantification of trace contaminants even in highly complex matrices.When integrated with advanced <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=37&amp;manufacturerItems=3">(U)HPLC systems</a>, dedicated quantitation software, and optimized sample preparation workflows, the system delivers reliable, compliant-ready results. Its intuitive operation and seamless software integration enhance laboratory productivity and analytical confidence.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_TSQ_Altis_Plus_EFOX_Edition_Triple_Quadrupole_Mass_Spectrometer_4354bbb447.jpg" alt="Thermo Scientific TSQ Altis Plus EFOX Edition Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_TSQ_Altis_Plus_EFOX_Edition_Triple_Quadrupole_Mass_Spectrometer_4354bbb447.jpg 207w," sizes="100vw" width="650" height="490"><h4>Key features</h4><ul><li>Extreme sensitivity for trace-level contaminant detection in environmental and food matrices</li><li>Exceptional robustness ensuring reliable, reproducible results and maximum uptime</li><li>Ultrafast SRM acquisition enabling higher compound throughput</li><li>High-selectivity H-SRM performance (0.2 Da FWHM) for improved signal-to-noise and confident target identification</li><li>Seamless integration with application-specific software to boost productivity</li><li>Intuitive operation delivering high-quality, defensible results regardless of user experience</li></ul><h4>Technical specifications</h4><ul><li>Mass range: 2–2010 m/z</li><li>Ion source: OptaMax NG</li><li>Technique: MS</li><li>Software compatibility: <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromeleon software</a></li><li>Dimensions (D × W × H): 840 × 760 × 680 mm</li><li>Weight: 125 kg</li><li>System type: TSQ LC-MS with dry pump</li><li>Applications: Environmental analysis, food safety testing</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_TSQ_Altis_Plus_EFOX_Edition_Triple_Quadrupole_Mass_Spectrometer_2_4c34dd7919.jpg" alt="Thermo Scientific TSQ Altis Plus EFOX Edition Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_TSQ_Altis_Plus_EFOX_Edition_Triple_Quadrupole_Mass_Spectrometer_2_4c34dd7919.jpg 220w," sizes="100vw" width="650" height="460">

Thermo Scientific Orbitrap Exploris EFOX Mass Detector

Orbitrap Exploris EFOX is an HRMS detector for screening, quantification, and profiling of trace contaminants in food and environmental analysis using full-scan acquisition and in-source CID.

The Thermo Scientific™ Orbitrap Exploris™ EFOX Mass Detector is an Orbitrap-based mass detector designed for accurate and reliable trace contaminant analysis in environmental and food safety applications. This high-resolution mass spectrometry system enables comprehensive screening, quantification, and sample profiling within a single analysis while supporting efficient laboratory workflows and regulatory compliance.The instrument combines high sensitivity, selectivity, and robust design with simplified workflows for both routine and advanced applications. Full-scan acquisition together with in-source fragmentation eliminates the need for time-consuming MS/MS method optimization. Integration with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Thermo Scientific™ Chromeleon™ software</a> ensures efficient data processing and management.<h4>Key features</h4><ul><li>High-resolution mass spectrometry for precise detection and quantification of trace contaminants</li><li>Supports targeted analysis, suspect screening, and comprehensive sample profiling</li><li>Streamlined workflows reducing operational and maintenance costs</li><li>Enables retrospective data analysis without sample reinjection</li><li>Integrated with Chromeleon™ CDS for efficient data processing</li></ul><h4>Technical specifications</h4><ul><li>Dimensions (D × W × H): 763 × 534 × 703 mm (30 × 21 × 27.6 in), without data system, vacuum rough pumps, and optional items</li><li>Mass accuracy:<ul><li>External calibration: &lt;3 ppm RMS drift over 24 h</li><li>1-point calibration: &lt;3 ppm RMS drift over at least 4 weeks</li><li>Internal lock mass: &lt;1 ppm RMS drift over 24 h</li><li>EASY-IC: &lt;1 ppm RMS drift for at least 5 days</li></ul></li><li>Mass resolution: Up to 90,000 at 200 m/z</li><li>Scan rates: Up to 22 Hz at resolution setting 15,000</li><li>Software compatibility: Chromeleon software</li><li>Weight: 120 kg (265 lbs)</li><li>Mass range: 50–1500 m/z</li><li>Technique: MS</li><li>Type: Orbitrap LC-MS</li><li>Unit size: Each</li></ul>

Eaton 9E2000I UPS

Reliable 2000 VA / 1600 W online UPS with double-conversion technology, ensuring continuous power protection, stable output, and easy integration for IT systems and analytical equipment.

The Eaton 9E2000I is a reliable double-conversion (online) UPS designed to provide continuous power protection for critical equipment. With a capacity of 2000 VA / 1600 W, it ensures stable voltage and frequency output, making it ideal for servers, networking devices, and laboratory or analytical instruments.The compact tower design allows easy integration into various environments, while the intuitive LCD interface provides clear status monitoring and control. High efficiency operation (up to 97.5% in eco mode) helps reduce energy consumption and operating costs.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eaton_9_E2000_I_UPS_3_af8342a083.jpg" alt="Eaton 9E2000I UPS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eaton_9_E2000_I_UPS_3_af8342a083.jpg 176w," sizes="100vw" width="1000" height="887"><h3>Key features</h3><ul><li>True online double-conversion topology for maximum protection</li><li>2000 VA / 1600 W output power</li><li>Wide input voltage range reduces battery usage</li><li>LCD display for real-time monitoring (load, battery, alarms)</li><li>Automatic voltage regulation and frequency stabilization</li><li>Cold start capability (startup without mains power)</li><li>Compatible with external battery packs for extended runtime</li><li>Communication ports (USB, RS232) for system integration</li><li>Compact tower form factor</li><li>High efficiency up to 97.5% (eco mode)</li><li>Automatic battery testing and deep discharge protection</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eaton_9_E2000_I_UPS_4_7c6bf8b875.jpg" alt="Eaton 9E2000I UPS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eaton_9_E2000_I_UPS_4_7c6bf8b875.jpg 178w," sizes="100vw" width="1000" height="878"><h3>Technical specifications</h3><ul><li>Power rating: 2000 VA / 1600 W</li><li>Topology: Online (double conversion)</li><li>Input connection: IEC C14</li><li>Output connections: 6 × IEC C13</li><li>Form factor: Tower</li><li>Battery type: Sealed lead-acid (internal)</li><li>Display: LCD</li><li>Communication: USB, RS232</li><li>Input voltage range: 176–300 V (without battery use)</li><li>Input frequency range: 40–70 Hz</li><li>Output voltage: 230 V (configurable 220/230/240 V)</li><li>Output waveform: Pure sine wave</li><li>Runtime: up to ~16 minutes at 50% load (typical)</li><li>Battery configuration: 6 × 12 V / 7 Ah</li><li>Software compatibility: Eaton Intelligent Power Manager, Intelligent Power Protector</li><li>Applications: Servers, IT infrastructure, analytical instruments, laboratory systems</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eaton_9_E2000_I_UPS_6_47619799ff.jpg" alt="Eaton 9E2000I UPS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eaton_9_E2000_I_UPS_6_47619799ff.jpg 179w," sizes="100vw" width="1000" height="872">

Eaton 9E3000I UPS

Reliable 3000 VA / 2400 W online UPS with double-conversion technology, delivering continuous power protection, stable output, and flexible integration for IT infrastructure and critical equipment.

The Eaton 9E3000I is a reliable double-conversion (online) UPS designed to provide continuous power protection for critical equipment. With a power rating of 3000 VA / 2400 W, it ensures stable voltage and frequency output, making it ideal for servers, networking infrastructure, and laboratory or analytical instruments.The compact tower design allows easy integration into various environments, while the intuitive LCD display provides clear real-time system monitoring.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eaton_9_E3000_I_UPS_3_21e5358d03.jpg" alt="Eaton 9E3000I UPS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eaton_9_E3000_I_UPS_3_21e5358d03.jpg 179w," sizes="100vw" width="1000" height="874"><h3>Key features</h3><ul><li>True online double-conversion topology for maximum protection</li><li>3000 VA / 2400 W output power</li><li>Pure sine wave output</li><li>Wide input voltage range (176–300 V)</li><li>LCD display for real-time monitoring (load, battery, alarms)</li><li>Voltage and frequency stabilization</li><li>Cold start capability (startup without mains power)</li><li>Compatible with external battery packs</li><li>USB, RS232 and communication card slot</li><li>Compatible with Eaton Intelligent Power Manager and Intelligent Power Protector software</li><li>Compact tower design</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eaton_9_E3000_I_UPS_5_94dcd6f68b.jpg" alt="Eaton 9E3000I UPS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eaton_9_E3000_I_UPS_5_94dcd6f68b.jpg 180w," sizes="100vw" width="1000" height="870"><h3>Technical specifications</h3><ul><li>Power rating: 3000 VA / 2400 W</li><li>Topology: Online (double conversion)</li><li>Input: IEC C20</li><li>Outputs: 6 × IEC C13, 1 × IEC C19</li><li>Phase: Single-phase input / output</li><li>Dimensions (W × H × D): 39.9 × 33 × 19 cm</li><li>Weight: 24.2 kg</li><li>Display: LCD</li><li>Communication:<ul><li>USB port (HID compatible)</li><li>Serial port (RS232)</li><li>Communication card slot</li></ul></li><li>Software: Eaton Intelligent Power Manager, Eaton Intelligent Power Protector</li><li>Battery:<ul><li>Maintenance-free sealed lead-acid (VRLA), 6 × 12 V / 9 Ah</li><li>Automatic battery test</li><li>Deep discharge protection</li></ul></li><li>Efficiency: up to 98% (eco mode)</li><li>Noise level: &lt;37 dB (at 1 m)</li><li>Operating temperature: 0 to 40 °C</li><li>Color: Black</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Eaton_9_E3000_I_UPS_2_aecae50e52.jpg" alt="Eaton 9E3000I UPS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Eaton_9_E3000_I_UPS_2_aecae50e52.jpg 181w," sizes="100vw" width="1000" height="865">

Linde REDLINE Pressure Regulators C 200/1 & C 200/2

REDLINE C 200 pressure regulators provide precise and stable gas control up to 6.0 purity, ideal for laboratory, analytical, and research applications.

The REDLINE C 200 series pressure regulators (models C 200/1 single-stage and C 200/2 dual-stage) are designed for precise control of non-corrosive gases with purity levels up to 6.0 (99.9999%), as well as gas mixtures containing low concentrations of corrosive components.These regulators ensure excellent pressure stability, high accuracy, and preservation of gas purity, making them ideal for demanding laboratory, analytical, and research applications.The C 200/1 single-stage version is suitable for applications with stable inlet pressure, such as gases supplied in liquid phase. The C 200/2 dual-stage version is specifically designed for systems where inlet pressure fluctuates, ensuring highly stable outlet pressure even under changing conditions.<h4>Key Features</h4><ul><li>High precision pressure regulation for analytical applications</li><li>Suitable for high-purity gases up to grade 6.0 (99.9999%)</li><li>Excellent outlet pressure stability (especially dual-stage version)</li><li>Designed to maintain gas purity and minimize contamination</li><li>Wide range of configurable outlet pressure ranges</li><li>Flexible configuration with multiple valve and purging options</li><li>Robust and reliable design for laboratory and R&amp;D environments</li></ul><h4>Technical Specifications</h4><ul><li>Inlet pressure: up to 230 bar</li><li>Outlet pressure ranges:<ul><li>C 200/1 (single-stage): 3 / 6 / 10 / 14 / 16 / 28 / 35 / 50 / 100 / 200 bar</li><li>C 200/2 (dual-stage): 1 / 3 / 6 / 10 / 14 bar</li></ul></li><li>Gas compatibility:<ul><li>Non-corrosive gases up to purity 6.0</li><li>Gas mixtures with low corrosive content</li></ul></li><li>Inlet connections:<ul><li>According to DIN 477 and gas specification</li></ul></li><li>Outlet connections:<ul><li>Compression fittings</li><li>Hose nozzles</li></ul></li></ul><h4>Available Configurations</h4><h5>Models</h5><ul><li>C 200/1 (Single-stage) Designed for applications with stable inlet pressure</li><li>C 200/2 (Dual-stage) Designed for fluctuating inlet pressure with maximum outlet stability</li></ul><h4>Optional Equipment</h4><ul><li>Shut-off valve (Type A)</li><li>Needle valve (Type B)</li><li>High-pressure side purge (Type P)</li><li>Inert/external gas purge (Type TP)</li><li>Purge manifold (Type EP)</li><li>Post-purge (Type DP – available only for C 200/2)</li></ul><h4>Applications</h4><ul><li>Laboratory gas supply systems</li><li>Analytical instrumentation (e.g., GC, LC, MS workflows)</li><li>Research and development environments</li><li>High-purity gas distribution systems</li><li>Any application requiring stable pressure and contamination-free gas delivery</li></ul>

Linde REDLINE Pressure Regulators C 300/1 & C 300/2

REDLINE C 300 pressure regulators provide precise and stable gas control up to 6.0 purity, ensuring reliability for laboratory, analytical, and research applications.

The REDLINE C 300 series pressure regulators (models C 300/1 single-stage and C 300/2 dual-stage) are designed for precise control of non-corrosive gases with purity levels up to 6.0 (99.9999%), as well as gas mixtures containing low concentrations of corrosive components.Thanks to their robust design and high-quality manufacturing, these regulators provide excellent pressure stability, accuracy, and long-term reliability. They are particularly well suited for demanding laboratory, analytical, and research applications where maintaining gas purity and consistent pressure is critical.The C 300/1 single-stage regulator is recommended for applications with relatively stable inlet pressure, such as gases supplied in liquid phase. The C 300/2 dual-stage version is intended for systems with fluctuating inlet pressure, ensuring highly stable outlet pressure and improved control under varying operating conditions.<h4>Key Features</h4><ul><li>Precise and stable pressure regulation for analytical workflows</li><li>Compatible with high-purity gases up to grade 6.0 (99.9999%)</li><li>Dual-stage version provides superior outlet pressure stability</li><li>Designed to maintain gas purity and minimize contamination risks</li><li>Wide range of adjustable outlet pressure settings</li><li>Modular design with multiple optional valve and purge configurations</li><li>High reliability for continuous laboratory and R&amp;D operation</li></ul><h4>Technical Specifications</h4><ul><li>Inlet pressure: up to 300 bar</li><li>Outlet pressure ranges:<ul><li>C 300/1 (single-stage): 3 / 6 / 10 / 14 / 16 / 28 / 35 / 50 / 100 / 200 bar</li><li>C 300/2 (dual-stage): 1 / 3 / 6 / 10 / 14 bar</li></ul></li><li>Gas compatibility:<ul><li>Non-corrosive gases up to purity 6.0</li><li>Gas mixtures with low corrosive content</li></ul></li><li>Inlet connections:<ul><li>According to DIN 477 and gas specification</li></ul></li><li>Outlet connections:<ul><li>Compression fittings</li><li>Hose nozzles</li></ul></li></ul><h4>Available Configurations</h4><h5>Models</h5><ul><li>C 300/1 (Single-stage) Designed for applications with stable inlet pressure</li><li>C 300/2 (Dual-stage) Designed for fluctuating inlet pressure with maximum outlet pressure stability</li></ul><h4>Optional Equipment</h4><ul><li>Shut-off valve (Type A)</li><li>Needle valve (Type B)</li><li>High-pressure side purge (Type P)</li><li>Inert gas purge (Type TP)</li><li>Purge manifold (Type EP)</li><li>Post-purge (Type DP – available only for C 300/2)</li></ul><h4>Applications</h4><ul><li>Analytical instrumentation (e.g., GC, LC, MS systems)</li><li>Laboratory gas supply systems</li><li>Research and development environments</li><li>High-purity gas distribution systems</li><li>Applications requiring precise pressure control and contamination-free gas delivery</li></ul>

Linde Nitrogen 5.0 – Gas Cylinder

Linde Nitrogen 5.0 (≥99.999%) for analytics, industry, and electronics. High-purity inert gas for purging, protection, and calibration.

Nitrogen 5.0 from Linde is a high-purity inert gas with a purity of ≥ 99.999%, designed for a wide range of industrial, analytical, and technological applications.Due to its chemical inertness and high purity, it is ideal as a protective, purge, and carrier gas in demanding processes where oxidation and contamination must be prevented. Nitrogen 5.0 is also widely used as a zero gas in analytical instrumentation, enabling precise baseline calibration.Its versatility makes it suitable for applications in metallurgy, chemical processing, food production, electronics, and semiconductor manufacturing.<h4>Key Features</h4><ul><li>High purity ≥ 99.999% (5.0 grade)</li><li>Chemically inert gas</li><li>Suitable for protective atmospheres</li><li>Stable performance in analytical applications</li><li>Versatile use across industries</li><li>Supplied in pressurized cylinders</li></ul><h4>Technical Specifications</h4><ul><li>Gas: nitrogen (N₂)</li><li>Purity: ≥ 99.999% (5.0 grade)</li><li>Supply form: pressurized gas cylinder<ul><li>10 L (200 bar)</li><li>20 L (200 bar)</li><li>50 L (200 bar)</li><li>50 L (300 bar)</li></ul></li></ul><h4>Applications</h4><ul><li>Protective and purge gas in metallurgy and metal processing</li><li>Chemical, food, and electronics industries</li><li>Carrier and protective gas in semiconductor manufacturing</li><li>Cutting gas for laser and plasma cutting (e.g., stainless steel)</li><li>Zero gas in analytical and measurement systems</li></ul>

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