An international team led by researchers from CEITEC Masaryk University has developed a computational method for designing entirely new antimicrobial peptides – short proteins capable of killing bacteria. Instead of relying on the lengthy process of searching for suitable molecules in nature, the researchers can now use molecular simulations to predict their properties and design new molecules with specific functions. The resulting peptides successfully eliminated bacteria resistant to conventional antibiotics and proved effective in preclinical mouse models. The findings introduce a new approach to developing future antibiotics as well as other biologically active peptides.According to the World Health Organization, antibiotic resistance is one of the greatest global health threats of our time. Every year, the number of bacteria resistant to available antibiotics continues to grow. At the same time, developing new drugs is a lengthy and costly process in which most candidate molecules ultimately fail.Researchers at CEITEC Masaryk University have therefore taken a different approach. Rather than searching randomly for antimicrobial compounds, they developed a method for designing them based on molecular design principles. Using molecular simulations, they analysed around 150 peptides in detail and identified the rules that govern the design of molecules capable of forming stable pores in bacterial membranes. These tiny openings disrupt the membrane barrier, causing bacteria to lose control of their internal environment and ultimately die. "We discovered how to arrange specific amino acids so that the resulting peptides form pores in bacterial membranes. This now allows us to generate an enormous number of peptide candidates and select those with the properties we are looking for," says <a target="_blank" rel="noopener noreferrer" href="https://www.ceitec.eu/prof-robert-vacha-ph-d/u27252">Robert Vácha</a> from CEITEC Masaryk University, who led the research.The researchers validated the most promising peptide designs experimentally. They confirmed their activity against a group of the most dangerous antibiotic-resistant bacteria. The best results were achieved against Acinetobacter baumannii, which the World Health Organization classifies as a priority drug-resistant pathogen. The team also demonstrated that their most successful peptide does not damage human red blood cells and shows no significant toxicity towards human cells. Its efficacy was further confirmed in two preclinical mouse models of bacterial infection.The significance of the study lies not only in identifying a new antibiotic candidate but, more importantly, in establishing a new design strategy. Based on their findings, the researchers developed a set of design principles and 52 sequence templates that can be used to design approximately 10 trillion molecules, providing other research teams with a framework for developing new membrane-disrupting peptides. The same principle that proved successful against bacteria could also be applied in the future to develop anticancer therapeutics, biosensors, or targeted drug delivery systems."Until now, researchers have mostly searched for biologically active molecules created by nature and only then investigated how they work. We reversed this process. First, we studied which molecular properties are required for a particular mechanism of action – in our case, the ability to stabilize membrane pores – and then used this knowledge to design entirely new peptides that make such pores. This approach could significantly accelerate the development of new medicines and help us keep pace with the growing challenge of antibiotic resistance," adds Robert Vácha, who has received ERC grants for his research.The study was carried out in collaboration with researchers from the University of Pennsylvania, the University of Groningen, Palacký University Olomouc, and the Institute of Microbiology of the Czech Academy of Sciences. The results were published in <a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41589-026-02269-z.epdf">Nature Chemical Biology</a>.<blockquote><h4>The original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41589-026-02269-z#citeas">Computational design of antimicrobial peptide nanopores</a></h4>Rahul Deb, Marcelo D. T. Torres, Ivo Kabelka, Jan Přibyl, Kateřina Dvořáková Bendová, Edo Vreeker, Markéta Koběrská, Gabriela Balíková Novotná, Miloš Petřík, Giovanni Maglia, Cesar de la Fuente-Nunez &amp; Robert VáchaNat. Chem. Biol., 2026, 22, 1–12<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1038/s41589-026-02269-z">https://doi.org/10.1038/s41589-026-02269-z</a>&nbsp;<h6>Licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>Antibiotic resistance is a global health threat, driving the need for new molecules that kill bacteria via nontraditional mechanisms. Here, we present a computational de novo design strategy for α-helical peptides that self-assemble into large, stable and membrane-spanning nanopores with antimicrobial activity, including in vivo efficacy against drug-resistant pathogens. Molecular dynamics simulations guided the selection of sequences for transmembrane barrel-stave pore formation, which were validated by microscopy, electrophysiology and fluorescence assays. Using computational and experimental analyses, including negative design controls, we developed general design guidelines and 52 modular sequence templates with tunable antimicrobial, pore-forming properties. Mechanistic studies confirmed bacterial cytoplasmic membrane disruption via designed nanopore formation. A tuned lead peptide selectively killed drug-resistant ESKAPEE bacteria, including Acinetobacter baumannii, without harming human cells, and showed anti-infective efficacy in preclinical mouse infection models. The framework presented here enables the design of synthetic peptide nanopores for precision antimicrobials, anticancer agents, molecular sensors and delivery systems.

New Antibiotics Designed on a Computer: Scientists Develop a Blueprint for Building Molecules Against Drug-Resistant Bacteria 

A new study published in Nucleic Acids Research identifies short “start–stop” elements as highly effective regulators of protein synthesis in human cells. The study was co-led by Leoš Shivaya Valášek from IMIC CAS.<section><div><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MBU_Nenapadne_start_stop_brany_reguluji_tvorbu_bilkovin_v_bunce_2_4d91bb348d.jpg" alt="MBU: Unassuming Start–Stop “Gates” Regulate Protein Production in Cells" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MBU_Nenapadne_start_stop_brany_reguluji_tvorbu_bilkovin_v_bunce_2_4d91bb348d.jpg 245w," sizes="100vw" width="720" height="390"><section><div>An international team of scientists has described a&nbsp;previously overlooked mechanism that regulates the levels of important proteins in human cells. A new study published in Nucleic Acids Research reveals that short regulatory “start–stop“ elements act as highly effective speed-limiting gates of protein synthesis. Compared with previously known regulatory sequences, these elements were found to suppress protein production even more efficiently. At the same time, they help maintain low but stable levels of important proteins in cells, even under stress conditions. The study brought together scientists from the United States, the Czech Republic, Canada, and Sweden. Leoš Shivaya Valášek, Head of the Laboratory of Regulation of Gene Expression at the Institute of Microbiology of the Czech Academy of Sciences (IMIC CAS) was a&nbsp;co-author and one of the corresponding authors of the study.</div></section><section><div>During protein production, ribosomes read and translate information encoded in messenger RNA (mRNA) into amino acids, which are then assembled into a&nbsp;new protein. The researchers focused on an unusual sequence in which a&nbsp;start signal is immediately followed by a&nbsp;stop signal. As a&nbsp;result, the ribosome receives instructions to begin and terminate translation almost simultaneously. Although such an arrangement may appear illogical, it proved to be an important regulatory tool.Start–stop motifs are found in more than 1,400 human genes and are particularly common in genes that control cellular signaling pathways, the stress response, or the activity of transcription factors—that is, proteins that regulate the activity of other genes. These genes must be tightly controlled because even small changes in the amount of their protein products can have significant biological consequences.<h4>Resilience Under Stress</h4>The researchers tested the activity of this regulatory mechanism under stress conditions, including in the ATF4 gene, which plays a&nbsp;key role in the so-called integrated stress response. Cellular stress is typically associated with a&nbsp;global reduction in protein synthesis. The authors demonstrated that regulation mediated by start-stop elements is largely independent of the overall state of translation initiation and therefore remains effective even under cellular stress.<h4>A Stronger Brake Than Known Regulatory Elements</h4>The team compared start–stop sequences with similar regulatory regions known as uTranslons. Although both types of elements suppress protein synthesis, the start–stop sequences proved to be significantly more effective. Ribosomes remain associated with these motives for longer before proceeding to the main coding region of the gene.“Start-stop sequences are specialized regulatory elements that ensure increased ribosome retention, thereby allowing for fine-tuning translation,” says Leoš Valášek from IMIC CAS.The study expands our understanding of how cells fine-tune protein synthesis and may ultimately contribute to research on &nbsp;certain cancer and neurodegenerative disorders, and other diseases linked to disrupted protein production.</div></section><blockquote><h4>The original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://academic.oup.com/nar/article/54/13/gkag627/8725953?login=false">Elongationless start–stop elements are stress-resilient translation gates that are more repressive than uTranslons</a></h4>Justin Rendleman, Solomon A Haizel, Shaohuan Wu, Laurelle Lee Young, Junjie Liu, Xinyi Ge, Huijing Zou, Mahabub Pasha Mohammad, Matthew Pressler, Shuvadeep Maity, Vladislava Hronová, Zhaofeng Gao, Anna Hermannová, Anna Smirnova, Amy Lei, Kristina Allgoewer, Daniel Sultanov, Will Edward Hinckley, Ziyue Cheng, Lauren Shelby, Tanubrata Dey, Krzysztof J Szkop, Ivan Topisirovic, Ola Larsson, Maria Hatzoglou, Leoš Shivaya Valášek, Christine VogelNucleic Acids Research (2026), Volume 54, Issue 13&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1093/nar/gkag627">https://doi.org/10.1093/nar/gkag627</a><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>Start–stop elements are translation regulatory elements in 5′ untranslated regions (UTR) of eukaryotic transcripts, consisting of a start codon immediately followed by a stop codon. In contrast to canonical upstream Translons (uTranslons), they exclude elongation which creates unique properties. We conducted a comprehensive, carefully controlled comparison of human start–stop elements and uTranslons both at a genome-wide level and with targeted reporter assays. We found that start–stops and uTranslons were similar with respect to their presence in the 5′ UTRs of hundreds of genes, in particular transcription factors and signaling molecules, the low transcript levels of the corresponding genes, short RNA half-lives, and the negative effect on downstream translation. However, start–stop containing genes were translationally even more repressed than genes with uTranslons. Analysing the start–stop architecture and diverse ribosome footprinting datasets, we found evidence for a start–stop-specific mechanism that involves repeat cycling between initiation, termination, ribosome splitting, and 60S rejoining—a process possibly modulated by ASCC3 and eIF1. This cycling explained increased ribosome retention at start–stops and was—in contrast to ribosome retention at uTranslons—independent of the global initiation state. Finally, we showed that the start–stop element in human ATF4 augments the core regulatory model by controlling translation of the uTranslons.</div></section>

Unassuming Start–Stop “Gates” Regulate Protein Production in Cells

Why Biologics QC Is So Much Harder Than Small Molecule Pharma

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The Czech Academy of Sciences (CAS) was established by Act No. 283/1992 Coll. as the Czech successor of the former Czechoslovak Academy of Sciences. It is set up as a complex of 54 public research institutions.

Czech Academy of Sciences

Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

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Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

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Characterization of polymers (Watrex)

Watrex Prague offers laboratory characterization of polymers using GPC.

<h4>WI08112 – Determination of Molecular Weight Distribution of Polymeric Materials</h4><ul><li>Determination by GPC method in water and THF, or optionally in other solvents upon request.</li><li>Each set of measurements requires calibration (WI08113).</li><li>Price: 3,300 CZK excl. VAT</li></ul><h4>WI08113 – Calibration for Molecular Weight Distribution of Polymeric Materials</h4><ul><li>Calibration using dextran, polymaltotriose, or polystyrene standards for GPC molecular weight distribution determination.</li><li>Price: 4,500 CZK excl. VAT</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_GPC_separace_polymeru_na_kolone_Watrex_Delta_Gel_47ce92deaa.jpg" alt="Watrex: GPC separation of polymers on Watrex DeltaGel column" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_GPC_separace_polymeru_na_kolone_Watrex_Delta_Gel_47ce92deaa.jpg 213w," sizes="100vw" width="1385" height="1018"><blockquote><h3>Services – Laboratory</h3>The Watrex Analytical Laboratory will be happy to perform any of our standard analyses, custom analyses, or assist you with method development.We specialize primarily in liquid chromatography techniques and are ready to meet a wide range of requirements—from method development and optimization, through validation and verification of external methods, to training and troubleshooting.Our laboratory also manufactures and packs its own chromatographic columns and guard columns for basic HPLC modes (reversed phase, normal phase, ion chromatography, and ion exclusion chromatography).<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Analyticka_laborator_fc8862fba5.jpg" alt="Watrex: Analytical Laboratory" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Analyticka_laborator_fc8862fba5.jpg 245w," sizes="100vw" width="1569" height="637"></blockquote>

Determination of ions, pH, and water hardness (Watrex)

Watrex Prague offers the determination of cations and anions in water and aqueous extracts, pH determination, and water hardness calculation.

<h4>WI08106 – Determination of Anions in Water</h4><ul><li>Determination of fluoride, chloride, nitrite, bromide, nitrate, phosphate, and sulfate ions in aqueous samples using ion chromatography.</li><li>Price: 1,825 CZK excl. VAT</li></ul><h4>WI081107 – Determination of Cations in Water</h4><ul><li>Determination of sodium, ammonium (NH₄⁺), potassium, calcium, and magnesium ions in aqueous samples using ion chromatography.</li><li>Price: 825 CZK excl. VAT</li></ul><h4>WI081108 – Determination of pH in Aqueous Samples</h4><ul><li>Measurement of pH in aqueous samples using a combined glass electrode. Approximately 20 mL of sample required.</li><li>Price: 115 CZK excl. VAT</li></ul><blockquote>10% discount when submitting 3 or more samples at once</blockquote><h3>Services – Laboratory</h3>The Watrex Analytical Laboratory will be happy to perform any of our standard analyses, custom analyses, or assist you with method development.We specialize primarily in liquid chromatography techniques and are ready to meet a wide range of requirements—from method development and optimization, through validation and verification of external methods, to training and troubleshooting.Our laboratory also manufactures and packs its own chromatographic columns and guard columns for basic HPLC modes (reversed phase, normal phase, ion chromatography, and ion exclusion chromatography).<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Analyticka_laborator_fc8862fba5.jpg" alt="Watrex: Analytical Laboratory" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Analyticka_laborator_fc8862fba5.jpg 245w," sizes="100vw" width="1569" height="637">

Identification of the substance – what is in your sample? (Bioanalytic)

We are able to identify metabolites and products of chemical reactions, contaminants of biological and chemical substances and preparations, and perform profiling of a series of samples to study the kinetics of transformations.

<h4>Substance Identification - Looking for answers to what's in your sample? - we can help you.</h4>Substance identification based on LC-MS/MS techniques can involve single compounds or mixtures of substances. In our analyses, we rely primarily on the knowledge and skills we have acquired after many years of work. For analysis, we use full laboratory facilities for sample preparation and high-resolution mass spectrometry (<a target="_blank" rel="noopener noreferrer" href="https://labexperts.com.pl/o-nas/">equipment</a>).We use different work algorithms depending on the material we are dealing with and the analytical task to be solved. We use DDA (IDA) or DIA (SWATH) methods or targeted approaches (e.g. MRMhr) if we know what to expect. Thus, we are able to identify metabolites and products of chemical reactions, contaminants of biological and chemical substances and preparations, and perform profiling of a series of samples to study the kinetics of transformations.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Bioanalytic_Bioanalytic_Identification_of_the_substance_what_is_in_your_sample_2_0f425a648b.jpg" alt="Bioanalytic: Identification of the substance – what is in your sample" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Bioanalytic_Bioanalytic_Identification_of_the_substance_what_is_in_your_sample_2_0f425a648b.jpg 245w," sizes="100vw" width="1881" height="1156"><h4>COST OF SERVICE</h4>We determine the cost of the service individually. The final cost is influenced by many factors related to the nature of the sample itself and the client's expectations. Thus, the price depends, among other things, on the complexity of the sample preparation procedure, the scope and number of analyses, etc.The service includes (depending on individual arrangements):<h5>Development of sample preparation procedure</h5><ul><li>Depending on the matrix and test substances.</li></ul><h5>Development of analytical methods</h5><ul><li>Application of high-resolution LC-MS/MS analyses using DDA (IDA) or DIA (SWATH) experiments and software to support the development of targeted screening methods.</li></ul><h5>Analysis of results includes:</h5><ul><li>finding and identifying the substances of interest, interpreting MS/MS spectra and proposing a structural formula.</li><li>Comparative analysis of sample series, e.g. PCA,</li><li>profiling of analytes in sample series</li></ul><h5>Reporting of results</h5><ul><li>Compile results into easy-to-read reports.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Bioanalytic_Bioanalytic_Identification_of_the_substance_what_is_in_your_sample_3_c1b8adc1d0.jpg" alt="Bioanalytic: Identification of the substance – what is in your sample" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Bioanalytic_Bioanalytic_Identification_of_the_substance_what_is_in_your_sample_3_c1b8adc1d0.jpg 245w," sizes="100vw" width="1919" height="1208">

Watrex application and R&D laboratory

Watrex application and R&D laboratory is providing a range of analyses.

Watrex application and R&amp;D laboratory is providing a range of analyses with special focus in the following fields:<ul><li>Chemical analysis for construction industry</li><li>Environmental analysis</li><li>Sample preparation including online solid-phase extraction protocols</li><li>Development of methods for pharmaceutical analysis</li><li>Characterization of synthetic polymers by GPC</li><li>Column technology and methods for chiral separation</li><li>Parameters evaluation and testing in ion chromatography applications</li></ul><h5>Our ready-to-go tests include:</h5><ul><li>Analysis of carbohydrates</li><li>Characterization of polymers</li><li>Analysis of organic acids</li><li>Construction analysis</li><li>Analysis of ions, pH and water hardness</li></ul>

Advanced PFAS Analytical Services (ALS)

Comprehensive PFAS analysis in water, soil, sludge, and AFFF sites using LC-MS/MS. Detect 60+ PFAS compounds, meet EU limits, and ensure compliance with evolving 2025 regulations.

<h4>Advanced PFAS Analytical Services</h4><h5>Ensuring Compliance, Safety and Environmental Responsibility</h5>Per- and polyfluoroalkyl substances (PFAS) are a group of synthetic chemicals widely used in industrial applications and consumer products. Their persistence in the environment and potential health risks have led to increasing regulatory scrutiny, particularly in drinking water and firefighting foam residues.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ALS_Advanced_PFAS_Analytical_Services_c8d8b28b7c.jpg" alt="ALS: Advanced PFAS Analytical Services" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ALS_Advanced_PFAS_Analytical_Services_c8d8b28b7c.jpg 245w," sizes="100vw" width="1604" height="502"><h4>Our Expertise</h4>We offer state-of-the-art analytical services for the detection and quantification of PFAS in:<ul><li>Drinking/ground/surface/waste water</li><li>Soil, sediment, sludge and biosolids</li><li>AFFF-contaminated sites and products</li></ul><h5>Using LC-MS/MS, our laboratories provide:</h5><ul><li>Ultra-trace level detection (ng range)</li><li>Analysis of over <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/enviromail_01_europe_the_scope_of_pfas_analyses_in_waters_and_current_state_of_legislation_6ebd4f1b6f/enviromail_01_europe_the-scope-of-pfas-analyses-in-waters-and-current-state-of-legislation.pdf">60 individual PFAS compounds</a></li><li>Non-targeted PFAS analysis like TOPA</li></ul><blockquote><h5>Contact Us</h5>Let us help you navigate the complex landscape of PFAS regulation and ensure your operations meet the highest standards of safety and compliance.<ul><li>+420 226 226 228</li><li><a href="mailto:customer.support@alsglobal.com">customer.support@alsglobal.com</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.alsglobal.eu/">alsglobal.eu</a></li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/ALS_PFAS_421ef75bea.jpg" alt="ALS: PFAS Analytical Services" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_ALS_PFAS_421ef75bea.jpg 156w," sizes="100vw" width="919" height="919"></blockquote><h4>Regulatory Context in Europe (2025)</h4>European legislation is rapidly evolving to address PFAS contamination:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://eur-lex.europa.eu/legal-content/EN/LSU/?uri=oj:JOL_2020_435_R_0001">The EU Drinking Water Directive (2020/2184) </a>mandates monitoring of PFAS, with a parametric value of 0.10 μg/L for the sum of 20 PFAS compounds</li><li><a target="_blank" rel="noopener noreferrer" href="https://eur-lex.europa.eu/legal-content/EN/TXT/?uri=OJ:L:2006:396:TOC">Reach Regulation 1907/2006</a> and the key <a target="_blank" rel="noopener noreferrer" href="https://eur-lex.europa.eu/eli/reg/2021/1297/oj/eng">Amendment Regulation 2021/1297</a>, targeting the C9-C14 perfluorocarboxylic acids and related substances</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.consilium.europa.eu/en/press/press-releases/2025/04/10/soil-monitoring-law-council-reaches-deal-with-parliament/">The Soil Monitoring law</a> (provisional agreement april 2025) includes PFAS as part of the soil Health assessment</li><li><a target="_blank" rel="noopener noreferrer" href="https://environment.ec.europa.eu/topics/water/water-framework-directive_en">The Water Frame Directive </a>with EQS on surface and groundwater and considerations for sediments and biota</li></ul><h3>List of PFAS analytes and report limits for determining PFAS substances in water</h3>For the sum of PFAS, a limit of 0.1 μg/l has been set, which applies to 20 substances marked with an asterisk (*) in the text below.<h5>Group: Perfluoroalkyl carboxylic acids</h5>Analyte / Abbreviation / Standard method (μg/l) / Low-limit method (μg/l)<ul><li>Perfluorobutanoic acid / PFBA* / 0.01 / 0.002</li><li>Perfluoro-3-methoxypropanoic acid / PFMPA / 0.025 / 0.001</li><li>Perfluoropentanoic acid / PFPeA* / 0.01 / 0.0003</li><li>Perfluoro-4-methoxybutanoic acid / PFMBA / 0.025 / 0.001</li><li>Perfluorohexanoic acid / PFHxA* / 0.01 / 0.0003</li><li>Tetrafluoro-2-(heptafluoropropoxy) propanoic acid / HFPO-DA / 0.02 / 0.001</li><li>Perfluoroheptanoic acid / PFHpA* / 0.01 / 0.0003</li><li>4,8-dioxa-3H-perfluorononanoic acid / DONA / 0.01 / 0.002</li><li>7H-perfluoroheptanoic acid / HPFHpA / 0.01 / 0.001</li><li>Perfluorooctanoic acid / PFOA* / 0.005 / 0.0003</li><li>Perfluoro-3,7-dimethyloctanoic acid / P37DMOA / 0.01 / 0.001</li><li>Perfluorononanoic acid / PFNA* / 0.01 / 0.0003</li><li>Perfluorodecanoic acid / PFDA* / 0.01 / 0.0003</li><li>2H,2H,3H,3H-Perfluorooctanoic acid / H4PFUnDA / 0.02 / 0.0003</li><li>Perfluorooctanoic acid / PFUnDA* / 0.01 / 0.0003</li><li>Perfluorododecanoic acid / PFDoDA* / 0.01 / 0.0003</li><li>Perfluorotridecanoic acid / PFTrDA* / 0.01 / 0.0003</li><li>Perfluorotetradecanoic acid / PFTeDA / 0.025 / 0.0003</li><li>Perfluorohexadecanoic acid / PFHxDA / 0.05 / n.a.</li><li>Perfluorooctadecanoic acid / PFOcDA / 0.05 / n.a.</li></ul><h5>Group: Perfluoroalkylsulfonic acids</h5>Analyte / Abbreviation / Standard method (μg/l) / Low-limit method (μg/l)<ul><li>Perfluoropropanesulfonic acid / PFPrS / 0.02 / 0.001</li><li>Perfluoro(2-ethoxyethane)sulfonic acid / PFEESA / 0.1 / 0.001</li><li>Perfluorobutanesulfonic acid / PFBS* / 0.01 / 0.0003</li><li>Perfluoropentanesulfonic acid / PFPeS* / 0.01 / 0.0003</li><li>Perfluorohexanesulfonic acid / PFHxS* / 0.01 / 0.0003</li><li>Perfluoroheptanesulfonic acid / PFHpS* / 0.01 / 0.0003</li><li>Perfluorooctane sulfonic acid / PFOS* / 0.005 / 0.0003</li><li>n-Decafluoro-4-(pentafluoroethyl) cyclohexane sulfonic acid / PFECHS / 0.01 / 0.0003</li><li>Perfluorononane sulfonic acid / PFNS* / 0.01 / 0.0003</li><li>Perfluorodecane sulfonic acid / PFDS* / 0.01 / 0.0003</li><li>Perfluorooctadecane sulfonic acid / PFUnDS* / 0.01 / 0.001</li><li>Perfluorododecane sulfonic acid / PFDoDS* / 0.01 / 0.0003</li><li>Perfluorotridecane sulfonic acid / PFTrDS* / 0.02 / 0.001</li></ul><h5>Group: Fluorotelomeric sulfonates</h5>Analyte / Abbreviation / Standard method (μg/l) / Low-limit method (μg/l)<ul><li>4:2 fluorotelomeric sulfonate / 4:2 FTS / 0.01 / 0.0003</li><li>6:2 fluorotelomeric sulfonate / 6:2 FTS / 0.01 / 0.0003</li><li>8:2 fluorotelomeric sulfonate / 8:2 FTS / 0.01 / 0.0003</li><li>10:2 fluorotelomeric sulfonate / 10:2 FTS / 0.01 / n.a.</li></ul><h5>Group: Perfluorinated sulfonamides</h5>Analyte / Abbreviation / Standard method (μg/l) / Low-limit method (μg/l)<ul><li>N-methyl-perfluorooctanesulfonamide / MeFOSA / 0.05 / 0.002</li><li>N-ethyl perfluorooctane sulfonamide / EtFOSA / 0.05 / 0.002</li><li>N-methyl perfluorooctane sulfonamidoethanol / MeFOSE / 0.025 / 0.002</li><li>N-ethyl perfluorooctane sulfonamidoethanol / EtFOSE / 0.025 / 0.002</li></ul><h5>Group: Perfluorooctane sulfonamidoacetic acid derivatives</h5>Analyte / Abbreviation / Standard method (μg/l) / Low-limit method (μg/l)<ul><li>Perfluorooctane sulfonamidoacetic acid / FOSAA / 0.01 / 0.001</li><li>N-Methyl perfluorooctane sulfonamidoacetic acid / MeFOSAA / 0.01 / 0.001</li><li>N-Ethyl perfluorooctane sulfonamidoacetic acid / EtFOSAA / 0.01 / 0.001</li></ul><h5>Group: Fluorotelomeric carboxylic acids</h5>Analyte / Abbreviation / Standard method (μg/l) / Low-limit method (μg/l)<ul><li>3-Perfluoropropyl propanoic acid (3:3) / 3:3 FTCA / 0.1 / 0.0003</li><li>n-2-Perfluorohexyl ethanoic acid (6:2) / 6:2 FTCA / 0.1 / 0.001</li><li>3-Perfluoropentyl propanoic acid (5:3) / 5:3 FTCA / 0.02 / 0.001</li><li>2H-Perfluoro-2-octenoic acid (6:2) / 6:2 FTUCA / 0.02 / 0.001</li><li>3-Perfluoroheptyl propanoic acid (7:3) / 7:3 FTCA / 0.02 / 0.0003</li><li>n-2-Perfluorooctyl ethanoic acid (8:2) / 8:2 FTCA / 0.1 / 0.001</li><li>2H-Perfluoro-2-decanoic acid (8:2) / 8:2 FTUCA / 0.02 / 0.001</li></ul><h5>Group: Chlorinated perfluoroalkyl sulfonic acids</h5>Analyte / Abbreviation / Standard method (μg/l) / Low-limit method (μg/l)<ul><li>9-Chlorohexadecafluoro-3-oxanonane-1-sulfonic acid / 9Cl-PF3ONS / 0.01 / 0.001</li><li>11-Chloroeicosafluoro-3-oxaundecane-1-sulfonic acid / 11Cl-PF3OUdS / 0.01 / 0.002</li></ul>*Analytes included in the sum of 20 PFAS in drinking water according to DIRECTIVE (EU) 2020/2184 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 16 December 2020 on the quality of water intended for human consumption.<h4>Applications</h4><ul><li>Site investigations and remediation planning</li><li>Compliance monitoring for water utilities</li><li>Environmental due diligence for industrial sites</li><li>AFFF legacy contamination assessments</li><li>Products compliance</li></ul><h4>Why Choose Us?</h4><ul><li>Accredited laboratories with experience in regulatory, diagnostic and scientific PFAS analyses</li><li>Rapid turnaround times and customizable reporting formats</li><li>Expert support for laboratories, environmental consultants, utilities, and industrial clients</li><li>Webinars by specialists in the field</li></ul><blockquote><h5>Read more about PFAS analysis:</h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/enviromail_02_europe_sampling_recommendations_for_pfas_to_maximize_data_quality_26c1da00bb/enviromail_02_europe_sampling-recommendations-for-pfas-to-maximize-data-quality.pdf">EnviroMail™ 02/Europe: Sampling Recommendations for PFAS to Maximize Data Quality</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/enviromail_10_europe_pfas_forever_chemicals_in_soil_a5b49ad7dd/enviromail_10_europe_pfas_forever-chemicals-in-soil.pdf">EnviroMail™ 10/Europe: PFAS: “Forever chemicals” in soil</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/enviromail_13_europe_passive_sampling_for_the_monitoring_of_pfas_in_water_feb2024_227a69e2dc.pdf">EnviroMail™ 13/Europe: Passive sampling for the monitoring of PFAS in water</a></li></ul></blockquote>

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