Propionic Acid Outperforms Formic and Acetic Acid in MS Sensitivity for High-Flow Reversed-Phase LC-MS Bottom-Up Proteomics
Scientific article | Science and research

Propionic Acid Outperforms Formic and Acetic Acid in MS Sensitivity for High-Flow Reversed-Phase LC-MS Bottom-Up Proteomics

Propionic acid increases peptide identifications by 39% versus formic acid in LC-MS proteomics while maintaining chromatographic performance and compatibility.
Propionic Acid Outperforms Formic and Acetic Acid in MS Sensitivity for High-Flow Reversed-Phase LC-MS Bottom-Up Proteomics
Toward Accurate Estimation of Extractable Organic Fluorine by Analysis of Fluoride Contamination in Extracts Using Gas Chromatography
Scientific article | Science and research

Toward Accurate Estimation of Extractable Organic Fluorine by Analysis of Fluoride Contamination in Extracts Using Gas Chromatography

A GC-MS/MS method quantifies inorganic fluoride in EOF extracts and shows that fluoride contamination can substantially overestimate organic fluorine measured by CIC.
Toward Accurate Estimation of Extractable Organic Fluorine by Analysis of Fluoride Contamination in Extracts Using Gas Chromatography
A Liquid–Liquid Extraction Method for Measuring Ultrashort PFCAs and Longer-Chain PFAS in Water
Scientific article | Science and research

A Liquid–Liquid Extraction Method for Measuring Ultrashort PFCAs and Longer-Chain PFAS in Water

A two-stage liquid–liquid extraction method enables sensitive, reproducible analysis of ultrashort PFCAs such as TFA and longer-chain PFAS in water.
A Liquid–Liquid Extraction Method for Measuring Ultrashort PFCAs and Longer-Chain PFAS in Water
Separation Sciences in the Czech Republic: From Historical Foundations to Recent Advances
Scientific article | Science and research

Separation Sciences in the Czech Republic: From Historical Foundations to Recent Advances

This review explores lesser-known Czech contributions to chromatography and electrophoresis and highlights recent advances in separation science and instrumentation.
Separation Sciences in the Czech Republic: From Historical Foundations to Recent Advances
An Analyte-Specific LC-IMS-HRMS Framework for Enhanced Identification Confidence in Target Screening of Contaminants in Complex Matrices
Scientific article | Science and research

An Analyte-Specific LC-IMS-HRMS Framework for Enhanced Identification Confidence in Target Screening of Contaminants in Complex Matrices

This LC-TIMS-HRMS framework combines CCS values, mobility filtering, and mandatory qualifier ions to reduce false positives and negatives in contaminant screening.
An Analyte-Specific LC-IMS-HRMS Framework for Enhanced Identification Confidence in Target Screening of Contaminants in Complex Matrices
Aromatase Inhibitor Therapy Is Associated with Distinct Plasma Lipidomic Profiles in Postmenopausal Breast Cancer Patients
Scientific article | Science and research

Aromatase Inhibitor Therapy Is Associated with Distinct Plasma Lipidomic Profiles in Postmenopausal Breast Cancer Patients

Mass spectrometry-based lipidomics identifies distinct plasma lipid changes linked to long-term aromatase inhibitor therapy in postmenopausal breast cancer patients.
Aromatase Inhibitor Therapy Is Associated with Distinct Plasma Lipidomic Profiles in Postmenopausal Breast Cancer Patients
New Synthetic Approach to C‑30 Ethers, Esters, and Amines of Betulin Using the Mitsunobu Reaction and Biological Evaluation of the Products
Scientific article | Science and research

New Synthetic Approach to C‑30 Ethers, Esters, and Amines of Betulin Using the Mitsunobu Reaction and Biological Evaluation of the Products

This study introduces an efficient Mitsunobu-based synthesis of C-30 betulin derivatives and identifies promising compounds with broad anticancer activity.
New Synthetic Approach to C‑30 Ethers, Esters, and Amines of Betulin Using the Mitsunobu Reaction and Biological Evaluation of the Products
Photocatalytic degradation and transformation of pharmaceuticals using exfoliated metal-free g-C3N4
Scientific article | Science and research

Photocatalytic degradation and transformation of pharmaceuticals using exfoliated metal-free g-C3N4

This study uses exfoliated g-C₃N₄ photocatalysts to degrade pharmaceuticals under visible light and identifies degradation pathways by LC-HRMS/MS.
Photocatalytic degradation and transformation of pharmaceuticals using exfoliated metal-free g-C3N4
ABCA7 deficiency exacerbates glutamate excitotoxicity in Alzheimer’s disease mice – A new pharmacological target for Glu-related neurotoxicity
Scientific article | Science and research

ABCA7 deficiency exacerbates glutamate excitotoxicity in Alzheimer’s disease mice – A new pharmacological target for Glu-related neurotoxicity

This study shows that ABCA7 deficiency amplifies glutamate excitotoxicity in Alzheimer's disease, highlighting a promising drug target.
ABCA7 deficiency exacerbates glutamate excitotoxicity in Alzheimer’s disease mice – A new pharmacological target for Glu-related neurotoxicity
Residue-Level Determination of Small-Molecule–Protein Affinities by Hydrogen–Deuterium Exchange Mass Spectrometry
Scientific article | Science and research

Residue-Level Determination of Small-Molecule–Protein Affinities by Hydrogen–Deuterium Exchange Mass Spectrometry

This study introduces an HDX-MS titration workflow for quantifying protein–ligand affinities at global, peptide, and residue resolution.
Residue-Level Determination of Small-Molecule–Protein Affinities by Hydrogen–Deuterium Exchange Mass Spectrometry