Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 9th September 2024? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring to you applications by Agilent Technologies, Shimadzu, and Thermo Fisher Scientific and poster by LECO from ACS meeting!<h4>1. Thermo Fisher Scientific: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_002952_gc_ms_isq_environmental_an002952_na_en_9738609742.pdf">Adhering to U.S. EPA Method 524.2 for the analysis of volatile organic compounds in drinking water</a></h4><ul><li>application</li></ul>Goal: Demonstration of a routine analytical method that meets the requirements outlined in U.S. EPA 524.2 for the quantitation of volatile organic compounds (VOCs) in drinking water, using the Teledyne LABS Tekmar Lumin Purge and Trap (P&amp;T) concentrator paired with the AQUATek LVA autosampler system along with a Thermo Scientific™ ISQ™ 7610 MS system coupled with a Thermo Scientific™ TRACE™ 1610 gas chromatograph (GC) and Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS). Method linearity, method detection limit (MDL), precision, and accuracy were assessed to evaluate method performance.Introduction: Analytical testing labs play a crucial role in monitoring surface, ground, and drinking water for volatile organic compounds (VOCs). Common by-products in the processing of household and industrial products, VOCs can contaminate water sources, potentially harming the environment and public health. To safeguard against this, labs use the U.S. EPA Method 524.21 to test water for the presence of VOCs, including four trihalomethane disinfection by-products. This procedure utilizes Purge and Trap (P&amp;T) procedures to remove VOCs with high volatility and low water solubility from water samples, followed by gas chromatography-mass spectrometry (GC-MS).Conclusion: The TRACE 1610 GC, the ISQ 7610 system, and the Tekmar Lumin P&amp;T with the AQUATek LVA autosampler system together offer benefits for executing U.S. EPA Method 524.2. The Tekmar Lumin P&amp;T concentrator enhances sample throughput through efficient trap cooling and moisture control, thus reducing peak interference and extending GC column life. The ISQ 7610 system’s VPI and ExtractaBrite ion source allow ionization source and analytical column replacement without venting the instrument, ensuring minimal downtime, and the XLXR™ detector offers extended linear dynamic range. The collective technology addresses routine VOC analysis challenges, ensuring robust sensitivity, maximized output, and consistent method compliance. The ISQ 7610 system equipped with the VPI coupled with the Tekmar Lumin P&amp;T and the AQUATek LVA autosampler exceeds all the requirements outlined in U.S. EPA Method 524.2 for analysis of VOCs in drinking water:<ul><li>Excellent linearity for all compounds was demonstrated with the %RSD of the calibration response factors passing all method requirements.</li><li>MDL and precision for seven 0.5 ppb standards showed no interference from excessive water and produced very reproducible results. The average MDL result for all 83 target compounds was 0.06 ppb with a precision of 4.06%.</li><li>The precision for n=31 samples over 189 injections displayed &lt;30% RSD accuracy for all compounds as the method requires. The average precision for all 83 target compounds and 2 surrogates gave a %RSD of 6.43% with an accuracy of 98% recovering the compounds. Individually, 4-bromofluorobenzene and 1,2-dichlorobenzene-d4 had a 7.68% RSD with an accuracy of 98% and 4.95% RSD and an accuracy of 95%, respectively, over 189 injections and almost four days of uninterrupted analysis.</li></ul><h4>2. Shimadzu: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00706_en_f95bd4b605.pdf">Analysis of Denatured Fuel Ethanol with Brevis GC-2050 Using ASTM D5501</a></h4><ul><li>application</li></ul>User Benefits<ul><li>The compact design of the Brevis GC-2050 enables space-saving in the laboratory.</li><li>As an alternative gas for helium, hydrogen can be used as the carrier gas.</li><li>&nbsp;Analysis of ethanol and methanol in fuels based on ASTM D5501 is possible.</li></ul>IntroductionBioethanol has attracted attention as a form of renewable energy which can be obtained from biomasssuch as corn and sugar cane. ASTM D5501 provides a test method for determination of the concentrations of ethanol and methanol in fuels for concentrations of ethanol from 20 to 100 wt% and concentrations of methanol from 0.01 to 0.6 wt%.In this Application News article, measurements of the purity of ethanol containing gasoline as a denaturant as specified in ASTM D5501 were carried out with a Brevis GC-2050 gas chromatograph, using helium and hydrogen asthe carrier gases.ConclusionEthanol purity tests were carried out as provided in ASTM D5501 using a Brevis GC-2050 gas chromatograph. The splitter linearity test showed no inlet discrimination so that accurate qualitative analysis could be made for denatured fuel ethanol with the wide boiling range components regardless of whether helium or hydrogen was used as the carrier gas.<h4>3. Agilent Technologies: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_aldehydes_beer_pal3_autosampler_5977c_gc_msd_5994_7633en_agilent_1fe3b8541c.pdf">Analysis of Aldehydes in Beer by Agilent PAL3 Autosampler and 5977C GC/MSD</a></h4><ul><li>application</li></ul>AbstractThis application note describes a method for quantitation of four aldehydes (hexanal, furfural, phenylacetaldehyde, and trans-2-nonenal) responsible for off-flavors in beer using an Agilent 8890/5977C GC/MSD with an Agilent PAL3 (SPME) autosampler. The method used fully automated, solvent-free extraction and on-fiber derivatization. The aldehyde compounds were derivatized with the derivatization agent O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine hydrochloride (PFBHA) using the on-fiber derivatization procedure. The derivatization agent was first adsorbed onto an Agilent 65 µm PDMS/DVB fiber. Next, the fiber was inserted into a 20 mL headspace vial containing a 2 mL beer sample with agitation at 60 °C for 30 minutes. Both extraction and derivatization procedures were automatically performed using the PAL3 autosampler. The method demonstrated excellent sensitivity, with detection limits of 0.0009 µg/L for hexanal, 0.52 µg/L for furfural, 0.015 µg/L for phenylacetaldehyde, and 0.003 µg/L for trans-2-nonenal. The limits of the quantification for the four compounds were 0.003, 1.72, 0.05, and 0.01&nbsp;µg/L, respectively. The four aldehydes were successfully quantified in four beer samples purchased from a supermarket. Good repeatability was demonstrated with RSD &lt; 4.9% based on three replicate injections of the four beer samples for all four&nbsp;aldehydes.ConclusionThis application note describes the quantitative analysis of four aldehydes (hexanal, furfural, phenylacetaldehyde, and trans-2-nonenal) responsible for off-flavors in beer using an Agilent 8890/5977C GC/MSD with a PAL3 (SPME) autosampler. This method offers the advantages of full automation, rapid analysis, solvent-free extraction, and on-fiber derivatization. With this automated solution, excellent sensitivity was demonstrated for the detection of hexanal (0.0009 μg/L), furfural (0.52 μg/L), phenylacetaldehyde (0.015&nbsp;μg/L), and trans-2-nonenal (0.003 μg/L). Four different brands of beer were analyzed, with hexanal detected in the range of 0.45 to 1.56 μg/L, furfural in the range of 6.62&nbsp;to 50.37 μg/L, phenylacetaldehyde in the range of 6.64 to 10.51&nbsp;μg/L, and trans-2-nonenal in the range of 0.031 to 0.062&nbsp;μg/L. Good repeatability was demonstrated with RSD&nbsp;&lt;&nbsp;4.9% based on three replicate injections of the four beer samples for all four aldehydes.<h4>4. LECO: <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/hf_acs21_lpss_284_c35134b9cd.pdf">Combining GC with MS and Olfactory Detection for a Variety of Food, Flavor, and Fragrance Analyses</a></h4><ul><li>Poster / ACS</li></ul>INTRODUCTIONGas chromatography (GC) coupled with mass spectrometry (MS) is an important tool for the characterization of a wide range of food, flavor, and fragrance samples. The components most likely to contribute to the aroma of a sample tend to be volatile and semi-volatile analytes, and GC-MS is well-suited for this type of analysis. Complex samples are effectively separated into the individual analyte components with GC. Time-of-Flight (TOF) MS detection provides important information towards the identification of these potentially important components of the sample with full m/z range data that can be library searched and that is also optimal for deconvolution algorithms. The incorporation of olfactory (O) detection with this data is particularly helpful for connecting the identified features with their contributions to the overall aroma or flavor. This type of sensory directed analysis highlights regions of interest and leads to specific analytes of interest for a focused review of the data. This combination of tools can separate and identify analytes and then determine those that are most important for contributing to the sensory characteristics of the sample. A variety of samples were analyzed with this combination of tools, and the benefits of using the information together are highlighted.CONCLUSIONSIn this work, the combination of a GC separation with MS and O for detection provided a powerful and efficient analytical platform to isolate individual analytes, identify those isolated analytes, and connect them to their sensory impacts. The olfactory data allowed for sensory directed analysis. In each case, the GC separation and full m/z range TOFMS data were crucial for determining the identification of the feature responsible for the characteristic aroma. This collection of tools was demonstrated for the characterization of the most aroma impacting components of a nutmeg essential oil, the distinction of sensory differences in cilantro, and the determination of an off-odor in beer.

News from LabRulezGCMS Library - Week 37, 2024

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in week 37, 2024? Check out new documents from the field of spectroscopy, especially ICP/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT ICPMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring to you applications and other documents by Agilent Technologies, Shimadzu, Thermo Fisher Scientific, and Metrohm!<h4>1. Thermo Fisher Scientific: <style type="text/css"></style><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/XX_72201_ICP_MS_5_Questions_Infographic_XX_72201_EN_de14a23b16.pdf">How to Choose Your ICP-MS Solution. 5 Questions about ICP-MS</a></h4><ul><li>other</li></ul>5 Questions about ICP-MS<ol><li>When is trace elemental quantification important?</li><li>What advanced applications are possible with ICP-MS?</li><li>Wha are high precision isotope ratios important?</li><li>How is interference removal achieved in ICP-MS</li><li>What are the typical detection limits of ICP-MS system?</li></ol><h4>2. Shimadzu: <style type="text/css"></style><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00512_en_ca79400760.pdf">Analysis of Stain-like Deposits on the Surface of Metal Machined Parts for the Transportation Industry Using the AIRsight Infrared/Raman Microscope</a></h4><ul><li>application</li></ul>User Benefits<ul><li>AIRsight makes it easy to quickly switch between infrared and Raman measurements without moving the target.</li><li>Materials up to 40 mm thick can be measured directly and non-destructively.</li><li>Raman spectroscopy is ideal for measuring micron-scale areas and rough surfaces.</li></ul>IntroductionWhen manufacturing metal machined parts, anti-rust oil or cleaning fluid from machine tools may remain on metal parts, potentially leading to stain-like deposits. These stains can cause issues, such as reacting with lubricating oil or causing poor plating adhesion. This Application News presents a case study of measuring stainlike deposits found on the surface of metal machined partsfor the transportation industry using the infrared-Raman microscope AIRsight.ConclusionThe analysis of stain-like deposits discovered on the surface of metal machined parts for the transportation industry using AIRsight was introduced. Raman spectroscopy allowed the qualitative identification of the stain components, which was difficult with infrared spectroscopy due to the surface's unevenness. AIRsight is very useful for the qualitative analysis of unknown samples by allowing rapid switching and measurement of both infrared and Raman spectroscopy without moving the sample. Additionally, it can measure thick samples like metal machined parts non-destructively.<h4>3. Agilent Technologies: <style type="text/css"></style><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_mea_triazine_analysis_5994_7579en_agilent_1a14b8d0a5.pdf">Quantitative Analysis of MEA-Triazine Hydrogen Sulfide Scavengers Through Innovative Transmission FTIR Spectroscopy</a></h4><ul><li>application</li></ul><h5>The Agilent Cary 630 FTIR spectrometer with DialPath module: transmission FTIR with variable path lengths</h5>AbstractA common contaminant in oil and gas extraction is hydrogen sulfide (H2S). Monoethanolamine-triazine (MEA-triazine) is one of the most used scavengers for H2S. Industrially, there are many challenges in measuring MEA-triazine concentration in aqueous solutions. This application note aims to develop a mid-infrared (mid-IR) method using an Agilent DialPath transmission module to measure the concentration of MEA-triazine in aqueous solutions. The analytical method described meets the requirements for quantifying MEA-triazine with different solvents, providing time savings, ease of use, and reduced susceptibility to pipetting errors due to viscosity.ConclusionThe Agilent Cary 630 FTIR spectrometer with DialPath module proves to be a highly effective, accurate, and user-friendly method for the quantitative analysis of MEA-triazine in aqueous solutions. The technique's excellent linearity and robustness against additives such as MeOH and IPA highlight its reliability. The DialPath module's innovative design simplifies the measurement process, enhances sample throughput, and reduces common issues such as leaks and air bubbles. This method offers a significant improvement over traditional analytical techniques, providing a practical solution for both field and laboratory measurements in the oil and gas industry.<h4>4. Metrohm: <style type="text/css"></style><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_nir_122_download_da32ea61a1.pdf">Quantification of water in lactose with the OMNIS NIRS Analyzer</a></h4><ul><li>application</li></ul><h5>Fast, non-destructive determination of water with NIRS</h5>Lactose is an important pharmaceutical product. Approximately 60% to 70% of pharmaceutical dosage forms contain lactose [1], and it is one of the largest pharmaceutical excipients by volume. Lactose can be used as a bulk filler for pharmaceutical tablets, as a binder to provide more strength to a dosage form, and it can also be added to facilitate the flow of a formulation during the production process. Moisture in lactose is undesirable at high levels as it causes the material to become sticky and bind to itself, forming hard clusters that may be difficult to break apart. USP specifies the water content range in lactose monohydrate from 4.5 % to 5.5 % [2]. The analysis of water in lactose is usually done with time-consuming methods. Near-infrared spectroscopy (NIRS) is a faster alternative. This Application Note shows the determination of water content in lactose with NIRS.CONCLUSIONThis Application Note demonstrates the feasibility to determine water content in lactose quickly and easily. NIR spectroscopy offers users a fast, cost-effective, and highly accurate alternative to other standard testing methods. Additionally, NIRS analysis is nondestructive, completely reagent-free, and gives results in only a few seconds.

News from LabRulezICPMS Library - Week 37, 2024

NIST, Wiley, and user-created EI mass spectral libraries are very powerful tools for the identification of organic compounds in complex mixtures by gas chromatography-mass spectrometry (GC-MS). &nbsp;This series of webinars will demonstrate the use of the NIST software suite including the NIST Search, AMDIS, and MS Interpreter for searching EI libraries. The series should be useful to a wide variety of research and developmental scientists involved in medical, environmental, industrial, forensic, and biological disciplines.<blockquote>The webinars demonstrate both Versions 3.0 (2023) and V2.4 of the NIST search. If you are using V3.0, start with Part 0. If you are using V2.4, start with Part I.</blockquote><h5>Today, we will look at:</h5><h3>Part II: Structure Searches with MS Search and Using MS Interpreter</h3><ul><li>Help Files for NIST Search</li><li>General Windows commands/functions</li><li>Primary Libraries of EI Spectra and Associated Structures</li><li>Select the libraries used for Exact Structure searches</li><li>Obtaining structures from chemical drawing program</li><li>Search for similar structures after inserting clipboard structure</li><li>Sending Structure from MS Search to drawing program&nbsp;</li><li>Tips for displaying structure search results</li><li>Tips for displaying related structures in structure searches</li><li>Search for exact structures</li><li>Using compare window to display multiple spectra</li><li>View of hit list structure search options utilized</li><li>MS interpreter for correlating structure to spectrum</li><li>Do the 3 isomers of methyl hydroxybenzoate fragment differently?</li><li>Any structure and associated spectrum sent to MS Interpreter</li><li>Accurate mass spectrum correlated to structure in MS Interpreter</li><li>Webinar references</li><li>Acknowledgements</li></ul><blockquote>Detailed Handouts including tables of content are available in the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ei_structure_searches_pt_ii_2_9e78dce7bb/ei_structure_searches_pt_ii-2.pdf">LabRulezGCMS library</a></blockquote><h4>Other parts of this series are focused on:</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/watch?v=KppCCeYTWTU">Part 0: Changes in EI NIST23 Program (V3.0)</a> (video only)</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/article/4438">Part I: Spectral Searches with NIST MS Search</a></li><li>Part II: Structure Searches with MS Search and Using MS Interpreter (this part)</li><li>Part III: AMDIS (NIST) for Processing EI Mass Spectral Data Files</li><li>Part IV: Advanced NIST Hybrid Search of EI and MS/MS Spectra</li><li>Part V: Creating and Sharing User EI and MS/MS Libraries</li><li>Part VI: Creating and Using Retention Indices in NIST Software</li><li>Part VII: &nbsp;Tracking Complex Coelution with AMDIS and NIST Search</li></ul><h4>Higher quality videos can be downloaded here:</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://drive.google.com/file/d/1XGOnO6vwyJv6rPucIH-NgOTBdvH1jNDg/view?usp=sharing">Higher Quality Video Part 0</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://drive.google.com/file/d/116Gzyh9nT4iDfJkac20K9aYarGvxpV2e/view?usp=sharing">Higher Quality Videos Pt. I-V Zipped</a></li></ul><h4>Other Webinar Resources:</h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://drive.google.com/file/d/1EGlEubUOWiNy3Y3mQZWdoaUXsFKTNjjj/view?usp=sharing">Test Files Used In Part VII for Tracking Coelution in Complex Mixtures with AMDIS and NIST</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2023/04/27/nist2023-library-and-software-available-in-early-june/">New NIST23 Brochures and Purchasing</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/wp-content/uploads/2023/07/nist_2023_release_presentation.pdf">NIST23 ASMS Presentation Houston, TX</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://blog.sepscience.com/massspectrometry/nist-23">NIST 23 Separation Science Article by David Sparkman</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/08/20/most-current-user-manuals-for-nist-search-and-amdis/">NIST and AMDIS User Manuals</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/08/20/most-current-user-manuals-for-nist-search-and-amdis/">NIST Approach for Creating Libraries</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/08/20/most-current-user-manuals-for-nist-search-and-amdis/">Databases Listed in Version 3.0 (2023)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.acdlabs.com/resources/free-chemistry-software-apps/chemsketch-freeware/">ACD Free Software</a> (structure drawing program personal/academic use)</li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2023/04/free-drawing-program-mass-spec-calculator-professional/">Mass Spec Calculator Professional</a> (free structure drawing program)</li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2011/08/28/using-nist-search-program-with-data-processing-and-drawing-programs/">Using with Manufacturers Data Processing Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/10/11/excel-deltamass-table-for-hybrid-searches/">Delta Mass Table (Excel Format)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/wp-content/uploads/2023/05/deltamass_ei.pdf">Delta Mass Table (PDF format)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2023/01/25/unknown-identification-presentation-at-current-trends-in-seized-drugs-analysis-symposium/">Hybrid Search/ChemSpider/SciFinder for Illicit Drug Identifications</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2011/08/28/using-nist-search-program-with-data-processing-and-drawing-programs/">Importing Mass Spectra to NIST Search Program</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2021/01/31/nist-ms-interpreter/">MS_Interpreter Correlating Structure to Spectrum</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/09/21/nists-suggested-settings-for-amdis-filter-settings/">NIST Tutorials and Settings for AMDIS</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/09/20/using-example-file-and-spectra/">Example Files for Part III AMDIS Webinar</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2020/09/20/using-example-file-and-spectra/">Example Spectra/Structures in Library Format Parts I-V</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/wp-content/uploads/2020/09/wiley_usermanual.pdf">Wiley Library User Manual with Spectral Source Codes</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/2011/08/28/using-nist-search-program-with-data-processing-and-drawing-programs/">Using with Manufacturers Data Processing Software</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://littlemsandsailing.com/wp-content/uploads/2020/12/observations-on-spectra-in-mona-database.pdf">Components in Free MONA Libraries</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://drive.google.com/file/d/1kGdFVnYYmrE-n1trB6ngVRPrSgyHsEx7/view?usp=share_link">MONA Library in EI format</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://drive.google.com/file/d/1os21j4L87oUmQ8GhQcIvX4edk6014JJ5/view?usp=drive_link">MONA and Other Free Libraries, 60,829 EI Spectra</a> (see read_me in zip file)</li></ul>

Effective Use of EI Mass Spectral Databases in Unknown Identifications - Part II: Structure Searches with MS Search and Using MS Interpreter

Analytical Scientists at the University of Amsterdam’s Van ‘t Hoff institute for Molecular Sciences together with colleagues from TNO have demonstrated for the first time that chemical warfare agents react with plant proteins to form stable protein adducts. These ‘biomarkers’ could still be detected in the living plants, as well as in dried leaves, up to three months after the actual exposure. This enables forensic reconstructions of the use of chemical weapons, which can assist investigations into alleged use in conflict areas.<figure class="image"><img style="aspect-ratio:1360/270;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/University_of_Amsterdam_HIMS_Analytical_Methods_Finding_evidence_in_plants_for_the_use_of_chemical_weapons_Photo_of_leaves_of_selected_plants_A_Bay_laurel_leaf_Laurus_nobilis_B_75d3501a91.jpg" alt="University of Amsterdam / HIMS: Photo of leaves of selected plants. (A) Bay laurel leaf (Laurus nobilis), (B) Basil (Ocimum basilicum), (C) Stinging nettle (Urtica dioica). Image taken from the paper." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_University_of_Amsterdam_HIMS_Analytical_Methods_Finding_evidence_in_plants_for_the_use_of_chemical_weapons_Photo_of_leaves_of_selected_plants_A_Bay_laurel_leaf_Laurus_nobilis_B_75d3501a91.jpg 245w," sizes="100vw" width="1360" height="270"></figure>The research was recently published as a ‘hot article’ in the scientific journal Analytical Methods and features on the cover. First author is Mirjam de Bruin-Hoegée who performed the research as part of her PhD study under supervision of Arian van Asten, professor of Forensic Analytical Chemistry and On Scene Chemical Analysis at the University of Amsterdam and one of the directors of the Amsterdam Center for Forensic Science and Medicine (CLHC). De Bruin-Hoegée cooperated with researchers at TNO Defence, Safety and Security in Rijswijk, and with scientists of various member states of the Organisation for the Prohibition of Chemical Weapons (OPCW) as part of its “Plant Biomarker Challenge”. The OPCW was awarded the Nobel Peace Prize in 2013 for its comprehensive efforts to eliminate chemical weapons.<h4>Abstract of the paper</h4>The continuing threats of military conflicts and terrorism may involve the misuse of chemical weapons. The present study aims to use environmental samples to find evidence of the release of such agents at an incident scene. A novel approach was developed for identifying protein adducts in plants.Basil (Ocimum basilicum), bay laurel leaf (Laurus nobilis) and stinging nettle (Urtica dioica) were exposed to 2.5 to 150 mg m−3 sulfur mustard, 2.5 to 250 mg m−3 sarin, and 0.5 to 25 g m−3 chlorine gas. The vapors of the selected chemicals were generated under controlled conditions in a dedicated set-up. After sample preparation and digestion, the samples were analyzed by liquid chromatography tandem mass spectrometry (LC-MS/MS) and liquid chromatography high resolution tandem mass spectrometry (LC-HRMS/MS), respectively.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/University_of_Amsterdam_HIMS_Analytical_Methods_Finding_evidence_in_plants_for_the_use_of_chemical_weapons_Graphical_abstract_8c9616273e.jpg" alt="University of Amsterdam / HIMS / Analytical Methods: Graphical abstract." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_University_of_Amsterdam_HIMS_Analytical_Methods_Finding_evidence_in_plants_for_the_use_of_chemical_weapons_Graphical_abstract_8c9616273e.jpg 245w," sizes="100vw" width="700" height="390">In the case of chlorine exposure, it was found that 3-chloro- and 3,5-dichlorotyrosine adducts were formed. As a result of sarin exposure, the o-isopropyl methylphosphonic acid adduct to tyrosine could be analyzed, and after sulfur mustard exposure the N1- and N3-HETE-histidine adducts were identified. The lowest vapor exposure levels for which these plant adducts could be detected, were 2.5 mg m−3 for sarin, 50 mg m−3 for chlorine and 12.5 mg m−3 for sulfur mustard. Additionally, protein adducts following a liquid exposure of only 2 nmol Novichock A-234, 0.4 nmol sarin and 0.2 nmol sulfur mustard could still be observed. For both vapor and liquid exposure, the amount of adduct formed increased with the level of exposure. In all cases synthetic reference standards were used for unambiguous identification.The window of opportunity for investigation of agent exposure through the analysis of plant material was found to be remarkably long. Even three months after the actual exposure, the biomarkers could still be detected in the living plants, as well as in dried leaves. An important benefit of the current method is that a relatively simple and generic sample work-up procedure can be applied for all agents studied.In conclusion, the presented work clearly demonstrates the possibility of analyzing chemical warfare agent biomarkers in plants, which is useful for forensic reconstructions, including the investigation into alleged use in conflict areas.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/University_of_Amsterdam_HIMS_Analytical_Methods_Finding_evidence_in_plants_for_the_use_of_chemical_weapons_aebfe37614.jpg" alt="University of Amsterdam / HIMS / Analytical Methods: Finding evidence in plants for the use of chemical weapons." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_University_of_Amsterdam_HIMS_Analytical_Methods_Finding_evidence_in_plants_for_the_use_of_chemical_weapons_aebfe37614.jpg 120w," sizes="100vw" width="700" height="908">

Finding evidence in plants for the use of chemical weapons

<h3>The Science</h3>At the subatomic level, electrons move so fast that attosecond strobe pulses are required to capture their motion. Researchers performed the first all X-ray attosecond-pump attosecond-probe experiment in condensed phase to observe electron motion, defining a method for spectral snapshots free of nuclear motion. The researchers established a technique called all X-ray attosecond transient absorption spectroscopy (AX-ATAS)—which involves synchronized attosecond X-ray pulse pairs—to study the electronic response to valence ionization in liquid water. This experiment provides the first real-time observation of X-ray induced electron dynamics at subfemtosecond timescales in the condensed phase.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pacific_Northwest_National_Laboratory_Nathan_Johnson_Attosecond_X_rays_Provide_a_Snapshot_of_Liquid_Water_Scientists_used_a_synchronized_pair_of_attosecond_X_ray_pulses_pictured_in_pink_4ddb7c913b.jpg" alt="Pacific Northwest National Laboratory / Nathan Johnson: Attosecond X-rays Provide a Snapshot of Liquid Water - Scientists used a synchronized pair of attosecond X-ray pulses (pictured in pink and green here) from an X-ray free electron laser to study the response of electrons (gold) in liquid water on attosecond timescale, while the hydrogen (white) and oxygen (red) atoms are &quot;frozen&quot; in time." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pacific_Northwest_National_Laboratory_Nathan_Johnson_Attosecond_X_rays_Provide_a_Snapshot_of_Liquid_Water_Scientists_used_a_synchronized_pair_of_attosecond_X_ray_pulses_pictured_in_pink_4ddb7c913b.jpg 245w," sizes="100vw" width="1600" height="1012"><h3>The Impact</h3>The study resolves a long-standing debate about the splitting observed in the X-ray emission spectrum of liquid water. It provides evidence that the splitting is due to dynamics and not two structural motifs, as previously thought. The methodology also enables future studies of the origin and evolution of reactive species produced by radiation-induced processes. As these processes are initiated by electronic motion at attosecond timescales, this technique is critical for understanding ultrafast reactions.<h3>Summary</h3>The all X-ray attosecond transient absorption spectroscopy (AX-ATAS) experiment was performed on liquid water using synchronized attosecond X-ray pulse pairs from the Linac Coherent Light Source operating in a harmonic configuration, omega (ω) and 2ω. The X-rays were focused on a thin, flat sheet of liquid water. The ω pump pulse ionized the valence band of liquid water, and the 2ω probe pulse interrogated the electronic structure.The researchers’ model showed that the polarization response in condensed-phase media observed with AX-ATAS is confined to the sub-femtosecond timescale, such that the resulting experimental spectra are free from nuclear motion. The researchers were then able to model the X-ray absorption spectra of the instantaneous post-ionization electronic structure using multi-reference restricted-active-space configuration interaction with fixed nuclear geometry. The findings, reported in the journal Science,&nbsp;provide a new window into the electronic structure of molecules in the liquid phase on a timescale previously unattainable with X-rays. The new technique reveals the immediate electronic response when a target is hit with an X-ray, an important step in understanding the effects of prolonged exposure to ionizing radiation. This research opens the doors for future work with more complex radiation-induced chemical solutions, like those found in legacy nuclear tank waste.Experimental work used the resources of the Linac Coherent Light Source (LCLS) at SLAC National Accelerator Laboratory. The multi-disciplinary team also included researchers from Argonne National Laboratory, the University of Chicago, the University of Washington, Pacific Northwest National Laboratory, SLAC, Hamburg Centre for Ultrafast Imaging and the&nbsp;Center for Free-Electron Laser Science (CFEL), Deutsches Elektronen-Synchrotron (DESY), in Hamburg, Germany.<h3>Contact</h3>Carolyn Pearce, Pacific Northwest National Laboratory, <a href="mailto:carolyn.pearce@pnnl.gov">carolyn.pearce@pnnl.gov</a>Linda Young, Argonne National Laboratory, <a href="mailto:young@anl.gov">young@anl.gov</a>Xiaosong Li, University of Washington, <a href="mailto:xsli@uw.edu">xsli@uw.edu</a><h3>Funding</h3>This work was primarily supported by IDREAM (Interfacial Dynamics in Radioactive Environments and Materials), an Energy Frontier Research Center funded by the Department of Energy (DOE), Office of Science, Basic Energy Sciences program (FWP 68932). Additional support was provided by the DOE, Office of Science, Basic Energy Science, Chemical Sciences, Geosciences and Biosciences Division, DESY (Hamburg, Germany), and the Cluster of Excellence "CUI: Advanced Imaging of Matter" of the Deutsche Forschungsgemeinschaft (DFG).

Attosecond X-rays Provide a Snapshot of Liquid Water

In analytical laboratories, precise handling of mobile phases and waste solvents is crucial to ensuring the reliability of chromatographic analyses and workplace safety. An essential part of this process is monitoring the levels of these liquids. <a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/chromatography/dedicated-instruments/lss-205-starter-kit/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty">The Watrex Liquid Sensing System LSS-205</a> offers a revolutionary solution that automates this task and reduces the risk of errors caused by human factors.<blockquote>Price: 578<bdi>&nbsp;€ ex VAT</bdi></blockquote><h3>Using the LSS-205</h3><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/chromatography/dedicated-instruments/lss-205-starter-kit/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty">The Watrex LSS-205</a> is a universal device designed to monitor liquid levels in any analytical system. The device is equipped with non-contact level sensors that do not require immersion in the liquid. These sensors are installed on the external surface of a non-metallic container, allowing them to be used on containers of virtually any shape and size. This effectively monitors both the solvent supply to the system and the condition of the waste solvent containers.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Level_sensors_installed_on_bottles_with_mobile_phases_5ed9d1742f.jpg" alt="Watrex - Level sensors installed on bottles with mobile phases..jpg" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Level_sensors_installed_on_bottles_with_mobile_phases_5ed9d1742f.jpg 234w," sizes="100vw" width="1737" height="1156"><h3>Functionality and Signaling</h3>The central unit of the LSS-205 can process signals from up to five level sensors simultaneously. Each of these sensors can be individually configured to trigger an alarm when the absence or presence of liquid is detected. When a deviation from the normal state is detected, this information is immediately indicated optically on the central unit. The optical signal is further supported by an acoustic alert, ensuring that the operator is promptly informed of the issue.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_The_connected_central_unit_and_green_monitor_light_indicating_that_the_mobile_phase_level_has_not_yet_dropped_below_the_set_level_dda36a33f4.jpg" alt="Watrex: The connected central unit and green monitor light indicating that the mobile phase level has not yet dropped below the set level." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_The_connected_central_unit_and_green_monitor_light_indicating_that_the_mobile_phase_level_has_not_yet_dropped_below_the_set_level_dda36a33f4.jpg 235w," sizes="100vw" width="1814" height="1207"><h3>Components and Connectivity</h3>The basic LSS-205 set includes not only the central unit and sensor but also an external optical signal, which uses color coding (green/red) for easy navigation. For more demanding environments where a standard alarm might go unnoticed, a loud siren is available as an optional feature. The device is also equipped with a microUSB connector for PC connection, allowing easy integration with other laboratory systems and more sophisticated liquid level record management.<figure class="image"><img style="aspect-ratio:2419/825;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Example_of_LSS_205_components_From_left_level_sensor_central_unit_and_traffic_light_for_optical_signaling_00ad52dd60.jpg" alt="Watrex: Example of LSS-205 components. From left: level sensor, central unit, and traffic light for optical signaling." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Example_of_LSS_205_components_From_left_level_sensor_central_unit_and_traffic_light_for_optical_signaling_00ad52dd60.jpg 245w," sizes="100vw" width="2419" height="825"></figure><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Traffic_light_attached_via_magnet_to_the_Watrex_Streamline_HPLC_system_The_traffic_light_is_glowing_red_indicating_that_the_mobile_phase_level_has_dropped_below_the_set_threshold_970b0f94df.jpg" alt="Watrex - Traffic light attached via magnet to the Watrex Streamline HPLC system. The traffic light is glowing red, indicating that the mobile phase level has dropped below the set threshold..jpg" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Watrex_Traffic_light_attached_via_magnet_to_the_Watrex_Streamline_HPLC_system_The_traffic_light_is_glowing_red_indicating_that_the_mobile_phase_level_has_dropped_below_the_set_threshold_970b0f94df.jpg 235w," sizes="100vw" width="1660" height="1104"><h3>Conclusion</h3>The Watrex Liquid Sensing System LSS-205 represents a key tool for modern laboratories that require a high level of control and automation in liquid handling for chromatographic systems. With its universal application, flexible sensors, and efficient signaling, it not only simplifies daily operations but also increases the safety and reliability of analytical processes. This system is an ideal choice for laboratories looking to minimize error risks and improve operational efficiency.For more information or a non-binding price quote, feel free to contact us at watrex@watrex.com.

A Helper That Alerts You in Time! Not only in HPLC.

"I like the non-violence of the environmental chemistry field. We're trying to help society," says analytical chemist Martin Palušák from the Institute for Nanomaterials, Advanced Technologies and Innovation, who is currently working on methods for reusing metals from mine water.Martin grew up in the popularity of Jurassic Park. He wanted to travel the world and discover dinosaurs, but over time he found chemistry and physics more interesting. "My chemist and I went to the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/62">Institute of Organic Chemistry and Biochemistry</a> of the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/10">CAS</a>. We went to a lab where they were studying the structures of proteins. It was in the basement, with an old couch against the wall and a shelf full of fantasy books next to it. And I thought, I have to do this. That's when I decided that I wanted to be a scientist," recalls Martin, who returned to the Institute of Chemical Biology as part of his bachelor's thesis. "It was a valuable experience, there are real experts working there," he says. So Martin studied biochemistry at the UK and ended up at the Faculty of Nuclear and Physical Engineering at the Czech Technical University, where he went on to complete his PhD.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CXI_TUL_Z_laborky_rovnou_na_longboard_Martin_Palusak_jede_ve_vede_a_adrenalinu_cover_image_0faeb1c613.jpg" alt="CXI TUL: Martin Palušák goes from lab to longboard: science and adrenaline" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CXI_TUL_Z_laborky_rovnou_na_longboard_Martin_Palusak_jede_ve_vede_a_adrenalinu_cover_image_0faeb1c613.jpg 245w," sizes="100vw" width="1080" height="670">In a white coat instead of a helmet on the dig siteEventually he returned from Prague to his native Liberec and currently works in the environmental chemistry laboratory at the Institute for Nanomaterials, Advanced Technologies and Innovations (<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/companies/319">CXI TUL</a>). "During my PhD I worked here two days a week. And then my wife was pregnant, so we decided to go back to our family. Everything goes better with the help of grandmothers," explains Martin.Martin values the freedom of self-realization and the opportunity to gain experience abroad. "We have a lot of international collaborations, I have gotten to places I would never have thought of in my life. I was in the oceanography lab. They had round windows on the door, just like on a ship. There were aquariums full of fish or even coral. Of course, we don't have that in the Czech Republic."Did his childhood dream come true? He travels the world and discovers. Not dinosaurs, but analytical methods.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CXI_TUL_Z_laborky_rovnou_na_longboard_Martin_Palusak_jede_ve_vede_a_adrenalinu_1_4827d2c497.jpg" alt="CXI TUL: Martin Palušák goes from lab to longboard: science and adrenaline." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CXI_TUL_Z_laborky_rovnou_na_longboard_Martin_Palusak_jede_ve_vede_a_adrenalinu_1_4827d2c497.jpg 156w," sizes="100vw" width="1080" height="1080">Hit the bull's-eyeAnd what would Martin recommend to budding scientists? "The most important thing is to choose the right field," he jokes."I chose environmental chemistry. I enjoy the fact that this field is trying to help society. For example, there is a lot of debate these days about whether or not there is global warming and who is to blame. We look for the facts and use them to decide on solutions to improve the current situation. In our case, for example, by treating water better or using neglected resources."The fact that Martin is passionate about chemistry is evidenced by the fact that he performed chemical experiments at schools and then taught organic chemistry and ran laboratories at the PhD level. "When I think about it, it was definitely an important experience. It made me realize how much I didn't know. Nowadays, teaching is no longer compulsory, but I think everyone who wants to work in a university should try it as a career."Did his childhood dream come true? He travels the world and discovers. Not dinosaurs, but analytical methods.From the lab straight to the longboardAnd what's Martin up to after work? He rides from the peaks of the Jizera Mountains on a longboard. He has no brakes, he controls everything with his body. "Now I take more care of myself for my family. I go slower, maybe 60 km per hour," explains Martin, who still relaxes after work by bouldering and of course with his wife and daughter.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CXI_TUL_Z_laborky_rovnou_na_longboard_Martin_Palusak_jede_ve_vede_a_adrenalinu_3_2536599565.jpg" alt="CXI TUL: Martin Palušák goes from lab to longboard: science and adrenaline." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CXI_TUL_Z_laborky_rovnou_na_longboard_Martin_Palusak_jede_ve_vede_a_adrenalinu_3_2536599565.jpg 229w," sizes="100vw" width="1627" height="1107">Horizon Europe TwinningMartin is working on several projects, one of the larger ones being <a target="_blank" rel="noopener noreferrer" href="https://surri.eu/">SURRI</a> (Sustainable Remediation of Radionuclide Impacts on Land and Critical Materials Recovery). It is a prestigious international Horizon Europe Twinning project. The main idea is to form a team and exchange know-how through the world.And what is the project about? The Czech Republic has been one of the main producers of uranium in recent years. After mining, there are many sites with high levels of radioactive substances or rare heavy metals. However, these can still be considered strategic raw materials. "The first problem that SURRI is addressing is how to clean up the mine water. This is because a huge amount of money is spent to ensure that contaminated water does not flow into the environment. But by cleaning the water, we concentrate strategic materials such as uranium or heavy metals. The next problem is how to access and reuse these valuable resources. The options are biological or chemical. I am working on electrochemical methods."Extracting metals from mine waterTo a layman, what Martin is doing can be described as having two magnets that can attract certain chemicals, but instead of magnetism, electricity is used. "Our partner, the University of Southampton, has a lot of experience in this and that helps us transfer their methods to our conditions. And it was an English university that was almost excluded because of Brexit. And then we have partnerships with Sapienza University of Rome and the University of Granada, and in the Czech Republic we work with the national company Diamo. SURRI is a project that promotes knowledge transfer."<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CXI_TUL_Z_laborky_rovnou_na_longboard_Martin_Palusak_jede_ve_vede_a_adrenalinu_2_d877d2c4c2.jpg" alt="CXI TUL: Martin Palušák goes from lab to longboard: science and adrenaline." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CXI_TUL_Z_laborky_rovnou_na_longboard_Martin_Palusak_jede_ve_vede_a_adrenalinu_2_d877d2c4c2.jpg 145w," sizes="100vw" width="1046" height="1124">Comprehensive methodology and other projectsThe end result of the project will be a comprehensive methodology using both chemical and biological methods for the reuse of valuable raw materials from mine water. "Ideally, SURRI will be followed by another project that would integrate our technologies into site-specific operations. I would like to be involved in this. I appreciate the fact that I write interesting projects," Martin explains enthusiastically."For example, when I came from Prague, I didn't know how to write projects. At CXI TUL, I was immediately involved in all the processes and they helped me get collaborations going pretty quickly. So far, my projects haven't worked out well. I am at the beginning of my career. But I'm still trying. It's probably best to take the plunge and not be afraid to work on it again and again. That's what I'm free to do here."For CXI TUL and across half the countryAnd where does Martin see himself in five years? "I would like to go back to my PhD studies, but now we are about to have another child, so it will be slower," he calculates, adding in one breath that he would like to stay at CXI TUL, simply because he is working with leading capacities in the field of environmental chemistry. "For example, there are scientists working here who do not hesitate to commute to Liberec from Prague every day," he says.

Martin Palušák goes from lab to longboard: science and adrenaline

<h3>Chiral ION-QN &amp; Chiral ION-QD</h3>Weak Anion-Exchanger (WAX) stationary phases for reliable chiral separation of acidic compounds<h4>Transform Your Chiral Analysis</h4>One of the main challenges of today’s liquid chromatography is chiral separation of ionised and ionisable analytes, e.g., organic acids, amino acids, N-protected amino acids, amino acid mimics, etc. The most efficient approach to purify and resolve such troublesome racemates utilises ion exchange-type stationary phases that facilitate strong interactions between the chiral selector and the analyte.Galochrom introduces its own generic series of weak anion-exchangers, based on tert-butyl-carbamoylated Cinchona alkaloids quinine (QN) and quinidine (QD). These chiral phases have demonstrated excellent selectivity and improved peak resolution, resulting in highly accurate and replicable analyses. Our innovative manufacturing and strict quality control ensure that these generic columns not only outperform commercial alternatives, but also meet your technical requirements.<blockquote>Chiral ION-QN &amp; Chiral ION-QD represent the most efficient approach to purify and resolve even the most challenging mixtures.</blockquote><h4>Applications</h4>Chiral ION-QN &amp; Chiral ION-QD are ideal for enantioseparations of:<ul><li>N-protected amino acids</li><li>Aminophosphonic &amp; Aminosulfonic acids</li><li>Lactic &amp; Thiolactic acids</li><li>Clenbuterol &amp; Thyroxin</li></ul><h4>Upgrade your separation performance and gain:</h4><ul><li>Premium enantioselectivity</li><li>Elegant switch of the elution order of enantiomers</li><li>High-stability against all common HPLC solvents</li><li>Seamless method transfer</li></ul><h3>Powerful Selectivity</h3>Aim for the best resolution and selectivity possibleIn collaboration with dozens of researchers, we have selected the best-performing derivatives of both quinine (QN) and quinidine (QD). As a result, the Chiral ION-QN features O-9-(tert-butylcarbamoyl)quinine, which is immobilized on fully-porous spherical silica (see below). The unique chiral scaffold of the cinchona backbone provides exceptional selectivity for wide array of acidic compounds.The Chiral ION-QD features structurally similar selector to Chiral ION-QN. As a result, these selectors, while being diastereomers, act as pseudo-enantiomers. This feature enables elegant switch of elution order of enantiomers, which is often challenging for other chiral stationary phases.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Galochrom_Chiral_ION_QN_and_Chiral_ION_QD_HPLC_columns_Transform_Your_Chiral_Analysis_3_18e49ab8ee.jpg" alt="Galochrom: Chiral ION-QN &amp; Chiral ION-QD HPLC columns - Transform Your Chiral Analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Galochrom_Chiral_ION_QN_and_Chiral_ION_QD_HPLC_columns_Transform_Your_Chiral_Analysis_3_18e49ab8ee.jpg 241w," sizes="100vw" width="1908" height="1238"><h4>Molecular recognition</h4>The prime driving force for specific molecular association are electrostatic or ionic interactions. Once analyte reaches close proximity of the selector, weaker non-bonding interactions such as H-bonding, π−π stacking and steric interactions apply. These directive interactions result in different column retention per each enantiomer.Since analytes differ in combination and strength of these binding increments, our chiral stationary phase delivers superior molecular recognition.<h4>Supporting professionals across many industries</h4><ul><li>Forensic Science</li><li>Chemical Manufacturing</li><li>Biotechnology</li><li>Agriculture</li><li>Academic Research&nbsp;</li><li>Pharmaceuticals</li><li>Food &amp; Quality Control</li></ul><h3>Popular chiral columns</h3>Essential tools with a wide range of applications<h4>Find your best match</h4>There are hundreds of chiral stationary phases available on the market. The selection of chiral HPLC columns below represents the most popular and top-performing choices for analysis and resolution of chiral acidic compounds. Displayed data are relevant to analytical and semi-preparative scale<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Galochrom_Chiral_ION_QN_and_Chiral_ION_QD_HPLC_columns_Transform_Your_Chiral_Analysis_4_5d48236baa.jpg" alt="Galochrom: Chiral ION-QN &amp; Chiral ION-QD HPLC columns - Transform Your Chiral Analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Galochrom_Chiral_ION_QN_and_Chiral_ION_QD_HPLC_columns_Transform_Your_Chiral_Analysis_4_5d48236baa.jpg 224w," sizes="100vw" width="1508" height="1052"><h4>Take Full Advantage Of Unique Selectivity And Expand Your Research Possibilities</h4>Chiral ION-QN &amp; Chiral ION-QD now available at ANALYTICAL &amp; PREPARATIVE scale<h3>Order information</h3><h4>Analytical Columns</h4><h5>Chiral ION-QN</h5><ul><li>Dimensions [mm]: 150 x 3</li><li>Porosity: [Å] 200</li><li>Cat. No.: ION01-A150</li><li>Price [€]: 1 300</li></ul><h5>Chiral ION-QD</h5><ul><li>Dimensions [mm]: 150 x 3</li><li>Porosity: [Å] 200</li><li>Cat. No.: ION02-A150</li><li>Price [€]: 1 300</li></ul>*As an alternative, we can also offer 150x3 mm, 3 μm with 120 Å<h4>Preparative Columns</h4><h5>Chiral ION-QN</h5><ul><li>Dimensions [mm]: 150 x 20<ul><li>Porosity: [Å] 120</li><li>Cat. No.: ION03-P150</li><li>Price [€]: 9 800</li></ul></li><li>Dimensions [mm]: 250 x 20<ul><li>Porosity: [Å] 120</li><li>Cat. No.: ION04-P250</li><li>Price [€]: 11 300</li></ul></li></ul><h5>Chiral ION-QD</h5><ul><li>Dimensions [mm]: 150 x 20<ul><li>Porosity: [Å] 120</li><li>Cat. No.: ION05-P150</li><li>Price [€]: 9 800</li></ul></li><li>Dimensions [mm]: 250 x 20<ul><li>Porosity: [Å] 120</li><li>Cat. No.: ION06-P250</li><li>Price [€]: 11 300</li></ul></li></ul><blockquote><h3>SPECIAL OFFER 1+1</h3>Buy 1 preparative column and get analytical column for FREEYou can choose 150x4 or 250x4 column with the same sorbent as your preparative column.</blockquote>

Chiral ION-QN & Chiral ION-QD HPLC columns - Transform Your Chiral Analysis

In the week from September 23, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4></blockquote><blockquote>👉 Search and filter in the largest global database with over 3 500 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1.&nbsp;Mettler-Toledo: Automated Data Management for LC/GC Workflows</h5><ul><li>Mo, 23.9.2024 10:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4226">Registration</a></li></ul>How can you support digitalized and scalable sample preparation processes for better chromatography results.<h5>2. Agilent Technologies: PFAS in Food Supply Chains: Regulations and Analytical Approaches: in association with AOAC India Section</h5><ul><li>Tu, 24.9.2024 08:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4281">Registration</a></li></ul>PFAS characteristics and the challenges they present to food safety.<h5>3. Waters Corporation: Chromatography - APGC</h5><ul><li>Tu, 24.9.2024 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4307">Registration</a></li></ul>Discover the advantages of GC coupled to MS under atmospheric pressure (Atmospheric Pressure GC/ APGC) as a powerful alternative to electron ionization (EI) for GC-MS.<h5>4. Agilent Technologies: Alcoholic Beverages Virtual Symposium: Wine</h5><ul><li>Tu, 24.9.2024 20:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4259">Registration</a></li></ul>How you can assure safety, authenticity, and quality of alcoholic beverages.<h5>5. Waters Corporation: General Sample Preparation</h5><ul><li>We, 25.9.2024 09:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4308">Registration</a></li></ul>Join us in exploring SPE key parameters and best practices for implementing successful SPE methods.<h5>6. Waters Corporation: Automated Sample Preparation</h5><ul><li>We, 25.9.2024 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4309">Registration</a></li></ul>The Andrew+™ pipetting robot offers fully automated liquid handling using electronic pipettes and labware holders.<h5>7. Agilent Technologies: Sample Cleanup: Method Development for Solid Phase Extraction and Beyond</h5><ul><li>We, 25.9.2024 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/3917">Registration</a></li></ul>We’ll discuss tips for selecting, developing, and implementing SPE methods. We’ll also discuss newly developed targeted filtration options and their benefits.<h5>8. LECO: Non-Targeted Screening in Sustainable Fuels: Exploring Method Development and Fuel Quality Assessment Using GCxGC-MS and Hyphenated Techniques</h5><ul><li>Th, 26.9.2024 14:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4296">Registration</a></li></ul>Embark on a journey of discovery in chemical analysis, with each instalments of our monthly webinar series delivering fresh perspectives and invaluable insights.

Webinars LabRulezGCMS Week 39/2024

In the week from September 23, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4></blockquote><blockquote>👉 Search and filter in the largest global database with over 3 500 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. Metrohm: Simplify your speciation analysis: Metrohm ion chromatography meets Agilent ICP-MS</h5><ul><li>Tu, 24.9.2024 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4280">Registration</a></li></ul>Key features of the integration of Metrohm IC with Agilent’s MassHunter software for ICP-MS.<h5>2. Agilent Technologies: Cary 3500 UV-VIS Advanced Analytical Capabilities and Seamless Server Connectivity</h5><ul><li>We, 25.9.2024 11:30 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4295">Registration</a></li></ul>Join the webinar to discover how this cutting-edge instrument elevates the standards of pharmaceutical analysis with its unique features and seamless OpenLab integration.<h5>3. Bruker: From Biological Exploration to Clinical Translation: Lipoproteins in Inflammation Response</h5><ul><li>We, 25.9.2024 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4228">Registration</a></li></ul>How our translational achievements in NMR technology are poised to revolutionize clinical research settings.<h5>4. Mettler-Toledo: Thermal Analysis of Inorganic Materials</h5><ul><li>Th, 26.9.2024 08:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/3918">Registration</a></li></ul>Discover Key Techniques for Characterizing This Diverse Group of Materials.<h5>5. Bruker: Hypoxia assessment using simultaneous multiparametric PET/MRI</h5><ul><li>Th, 26.9.2024 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4230">Registration</a></li></ul>Simultaneous PET/MRI methods and challenges in the characterization of hypoxia-induced physiological differences between breast cancer subtypes.

Webinars LabRulezICPMS Week 39/2024

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Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

The University of Amsterdam is one of the largest comprehensive universities in Europe. With some 40,000 students, 6,000 staff, 3,000 PhD candidates, and an annual budget of more than 850 million euros, it is also one of Amsterdam’s biggest employers.

There is an inseparable link between the university and its host city. The freedom and creativity with which Amsterdam has long been associated have worked their way into the fabric of the university. This is a place where individuality, authenticity and diversity are celebrated as sources of stimulation, inspiration and innovation.

Professional and personal development, challenges and collaboration are undertaken in a versatile and multidimensional (inter)national ecosystem with leading stakeholders. Staff at the UvA make a meaningful contribution to uncovering solutions to some of the world’s most significant problems and to developing the next generation of talent.

University of Amsterdam

Galochrom is a chromatography pioneer, providing custom solutions for HPLC separations, compound purification and method development.

Galochrom

Pacific Northwest National Laboratory advances the frontiers of knowledge, taking on some of the world’s greatest science and technology challenges. PNNL is a U.S. Department of Energy national lab with distinctive strengths in chemistry, Earth sciences, biology, and data science that are central to our scientific discovery mission. PNNL’s research lays a foundation for innovations that advance sustainable energy through decarbonization and energy storage and enhance national security through nuclear materials and threat analyses. PNNL collaborates with academia in its fundamental research and with industry to transition technologies to market.

Pacific Northwest National Laboratory

The Institute for Nanomaterials, Advanced Technologies and Innovations of the Technical University of Liberec, also known as CXI TUL, was founded in 2009. Our mission is to support TUL's long-term vision of collaboration with industry and innovation.

CXI TUL

My main interest is the identification of organic compounds by mass spectrometry in organic mixtures.

James Little/Mass Spec Interpretation Services

WATREX Prague is the distributor and producer of HPLC techniques in the Czech Republic and Slovakia. Main Chromatografic and Related Techniques Supported: LC, GPC, IC, IEC, Automated SPE, LC Columns and special column packings, LC method development, Software development, Laboratory Robots.

Webinars LabRulezICPMS Week 39/2024

Webinars LabRulezGCMS Week 39/2024

Chiral ION-QN & Chiral ION-QD HPLC columns - Transform Your Chiral Analysis

Martin Palušák goes from lab to longboard: science and adrenaline

Attosecond X-rays Provide a Snapshot of Liquid Water

A Helper That Alerts You in Time! Not only in HPLC.

Finding evidence in plants for the use of chemical weapons

Effective Use of EI Mass Spectral Databases in Unknown Identifications - Part II: Structure Searches with MS Search and Using MS Interpreter

News from LabRulezICPMS Library - Week 37, 2024

News from LabRulezGCMS Library - Week 37, 2024

Upcoming events

Analytical Insights Tour: From Food to Nutraceuticals

SCIEX at SOFT/TIAFT

LECO Training Course CS-744/844 Series & ON/ONH-736/836 Series

Webinars

From Sample to Reliable Result: How to Optimise Particle Concentration Measurements on the Zetasizer Advance

What defines an Aroma? Advanced GC-MS strategies for fragrance characterization and off-odor analysis

Next-Generation Pathogen Genomics: The Long-Read Advantage