<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 21st September 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies, LECO </strong>and <strong>Shimadzu</strong> and technical note by <strong>Thermo Fisher Scientific!</strong></p><h3><strong>1. Agilent Technologies: Automated Analysis of Foods by ICP-QQQ with Discrete Sampling and Autodilution</strong></h3><p><strong>Fast, accurate AOAC compliant food analysis using the </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=9500"><strong>Agilent 9500 ICP-QQQ</strong></a><strong> with AVS MS and ADS 2&nbsp;</strong></p><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_automated_food_analysis_9500_icp_qqq_5994_9095en_agilent_e5869385b0.pdf"><strong>Full PDF for download</strong></a><strong>&nbsp;</strong></li></ul><p>Manufacturers and regulatory bodies, including state and federal governments, have an obligation to ensure that food is safe for human consumption. To protect public health, manufacturers and producers follow rigorous testing procedures, such as AOAC Official Method 2015.01 for the analysis of heavy metals in foods using ICP-MS.1 In recent years, global initiatives have sought to strengthen existing regulations and further reduce contaminant limits, as shown by the US Food and Drug Administration’s Closer to Zero program. Meeting these increasingly stringent targets depends on analytical instruments capable of delivering higher performance, improved sensitivity, and greater accuracy. At the same time, food testing laboratories are actively pursuing greater productivity and workflow efficiency to keep pace with evolving analytical demands.</p><p>To support these goals, the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=9500"><strong>Agilent 9500 Triple Quadrupole ICP-MS</strong></a> (ICP-QQQ) and Advanced Dilution System (ADS 2) combine seamlessly to streamline methods, improve productivity, and deliver high-quality results. Using the 9500 instrument’s unique Dual-Cell System (DCS) with Advanced Helium Mode (AHM) and Air cell mode enables effective removal of polyatomic and doubly charged interferences and enhances low-mass sensitivity.2,3 In addition, the ADS 2 simplifies sample preparation by creating calibration standards from a stock solution, pre-diluting samples before analysis, and reactively diluting any samples that exceed the calibration range. Together, these technologies support faster, more reliable delivery of accurate results.&nbsp;</p><p>In this study, various standard reference materials (SRMs) were selected to represent different sample types that may be analyzed in food testing laboratories and to validate the method. As these laboratories often require high productivity, the 9500 ICP-QQQ configuration and analytical method were optimized to maximize sample throughput. The performance of the method was evaluated according to criteria set out in the AOAC 2015.01 method.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>The Agilent 9500 ICP-QQQ with Dual-Cell System (DCS) successfully quantified a broad range of metals in diverse food matrices in accordance with an AOAC standard method. Most elements were measured in AHM, while As and Se were accurately determined at trace levels in Air cell mode using ambient air to eliminate severe doubly charged REE interferences. AHM mode effectively suppressed polyatomic interferences such as NaAr on Cu, even in samples such as NIST 1573a Tomato Leaves, where Na is present at more than 20 times the concentration of Cu.&nbsp;</p><p>Together, the two DCS gas modes provided comprehensive interference control for routine food analysis, as demonstrated by recoveries of certified elements within ±25% for the food SRMs.&nbsp;</p><p>Compared to single-quadrupole ICP-MS, DCS operation in both modes reduced analysis time by about 30 seconds per sample. Automation using the Agilent AVS MS discrete sampling accessory, SPS 4 autosampler, and ADS 2 autodilutor further improved productivity and delivered reliable results, including:&nbsp;</p><ul><li>Detection limits for As, Cd, Pb, and Hg well below the LOQs reported in AOAC 2015.01&nbsp;</li><li>Effective removal of REE2+ interferences on As and Se&nbsp;</li><li>Over 98% Lu recoveries across all SRMs, demonstrating excellent preservation of volatile elements throughout the analysis&nbsp;</li><li>Stable operation over five hours, maintaining CCV and ISTD recoveries within AOAC limits&nbsp;</li></ul><p>The 9500 ICP-QQQ enables high-throughput, AOAC-compliant food analysis by controlling interferences with AHM and Air cell mode, ideal for labs that need speed, reliability, and accuracy.</p><h3><strong>2. LECO: Determination of Total Carbon (TC) and Total Organic Carbon (TOC) in Soil by Acid Digestion and Combustion</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/832_TC_TOC_SOIL_ACID_DIGESTION_COMBUSTION_203_821_679_e5b4978a69.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Total organic carbon (TOC) determination in soil is a widely used method for evaluating soil quality in agriculture. TOC levels are a key indicator of soil vitality, fertility, and capacity for atmospheric carbon sequestration. TOC represents the carbon stored in soil organic matter, which plays a vital role in supporting microbial life, enhancing nutrient availability, and improving soil structure. These benefits translate directly into better water retention, reduced erosion, and more resilient crops—key factors for regenerative systems focused on ecosystem restoration and productivity. TOC levels can also be used to monitor the effectiveness of sustainable practices like crop rotation, cover cropping, reduced tillage, and the addition of organic matter such as manure and compost. Measuring soil TOC levels helps growers optimize the use of soil amendments like compost and manure to increase organic matter without over-application.</p><h4><strong>Instrument Model and Configuration&nbsp;</strong></h4><p>The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1883"><strong>LECO C832</strong></a> is a carbon determinator that utilizes hightemperature combustion in a whole oxygen environment to analyze a wide range of sample types. It features a ceramic combustion furnace in a horizontal orientation designed to analyze macro sample masses. Analysis begins when a sample is weighed into a ceramic combustion boat and inserted into the furnace where combustion is initiated under a controlled flow of oxygen. After a preset time, additional oxygen is applied directly above the sample using a ceramic lance to accelerate and complete the combustion process. The gases are swept from the furnace and passed through anhydrone for the removal of moisture and are then carried to a nondispersive infrared (NDIR) cell for detection of carbon as CO<sub>2</sub>.</p><h4><strong>Typical Results&nbsp;</strong></h4><p>For soils containing up to 5 % carbon, a linear, force through origin calibration using LECO synthetic carbon reference materials is recommended. For soils containing more than 5 % carbon, a linear, full regression calibration using LECO synthetic carbon and calcium carbonate reference materials is recommended.</p><h3><strong>3. Shimadzu: Determination of More Than 25 Nutritional, Essential and Toxic Elements in Whole Blood by ICP-MS Using Alkaline Dilution</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_05_sca_116_014_en_5fc2b521ce.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>Offering gas switching times &lt;5 sec and ProActive Rinsing function, short sample cycle times can be achieved&nbsp;</li><li>Using whole blood calibrators and control samples in research labs simplifies working routines&nbsp;</li><li>Alkaline media drastically improves washout capabilities for mercury and ensures proper sample stabilization compared to acidic media</li></ul><p>Inductively coupled plasma mass spectrometry (ICP-MS) like <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=1&amp;search=2050"><strong>Shimadzu ICPMS-2050</strong></a> offers ultra-low detection limits and fast multi-element capability required for reliable high throughput measurement of nutritional, essential, and toxic elementsin various complex biological samples.&nbsp;</p><p>While urine has been widely used to monitor elemental excretion, blood serum represents the protein-free fraction of circulating blood. Whole blood, however, contains both cellular and extracellular components, enabling a more integrated assessment of an individual’s nutritional status and exposure to potentially toxic metals than either urine or serum alone. Accordingly, whole-blood ICP-MS analysis is well suited for research applications such as nutritional assessment, toxicology, and biomonitoring studies.</p><h4><strong>Conclusion</strong></h4><p>The ICPMS-2050 LF was specifically configured for robust small volume analysis while reducing carry over, sample cycle times and environmental contamination impacts while being capable of successfully addressing several kind of possibly interference providing most accurate and reliable results.&nbsp;</p><p>The collision- and reaction cell performs efficiently with flowrates of helium and hydrogen in low levels of 6-7mL/min. At the same time, the method uses the well established Minitorch plasma system, allowing lowest argon consumption while reducing power consumption, which makes it exceptionally cost-effective without compromising performance characteristics.&nbsp;</p><p>LabSolutions ICPMS software allows to easily control the device, consumable lifetime, QC-recoveries and internal standard stability. Furthermore, features like ProActive Rinsing and Extended Rinsing speed up the method while reducing carryover risks.</p><h3><strong>4. Thermo Fisher Scientific: User-defined calibrations with Niton XL5 Plus user mode</strong></h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/user_defined_calibrations_with_niton_xl5_plus_user_mode_tn1732_en_fc054105e5.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1992"><strong>Thermo Scientific™ Niton™ XL5 Plus Handheld XRF Analyzer</strong></a><strong> </strong>(shown in Figure 1) features a software function called User Mode, designed for experienced users who need to create their own calibrations.</p><p>User Mode has been developed to provide maximum flexibility for performing empirical calibrations. It allows the user to specify certain parameters and to proceed with analytical method development:&nbsp;</p><ul><li>Define and select optimal beam conditions, including filter material and voltage*, while the current is dynamically adjusted to the maximum value.&nbsp;</li><li>Select elements and regions of interest from Na to U.&nbsp;</li><li>Select up to 12 background regions to perform background correction, background subtraction, or Compton normalization.&nbsp;</li><li>Select units of measurement for bulk concentrations, coat weight, and coating thickness.&nbsp;</li><li>Acquire normalized count rates for all selected regions of interest.&nbsp;</li><li>Construct calibration curves and apply mathematical fitting (Figure 2).&nbsp;</li><li>Manually enter calibration model equations for selected analytes as a function of element and background region intensities.&nbsp;</li><li>Validate the calibration model.&nbsp;</li><li>Analyze unknown samples.</li></ul>

News from LabRulezICPMS Library - Week 39, 2026

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 29th September 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies, LECO </strong>and<strong> Shimadzu!</strong></p><h3><strong>1. Agilent Technologies: Sensitive and Reproducible Determination of Organochlorine Pesticides in Water</strong></h3><p><strong>Large volume injection and dual-column confirmation with the Agilent GC/ECD system</strong></p><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_organochlorine_pesticides_water_gc_ecd_system_5994_9441en_agilent_61787a0901.pdf"><strong>Full PDF for download</strong></a></li></ul><section><div><div><div><div><div><div><p>Organochlorine pesticides (OCPs) remain important environmental contaminants due to their persistence, bioaccumulation potential, and toxicity. Regulatory laboratories often require sensitive and robust analytical methods capable of detecting these compounds at trace levels in environmental samples. USEPA Method 8081B is commonly used for the analysis of organochlorine pesticides using GC/ECD due to the strong electron-capturing properties of halogenated compounds.<sup>1</sup>&nbsp;</p><p>Large volume injection (LVI) techniques can significantly improve detection sensitivity by introducing more analyte mass into the GC system. However, successful LVI implementation requires careful optimization to minimize solvent flooding, peak distortion, and poor chromatographic performance. The Agilent Multimode Inlet (MMI) provides a flexible solvent vent mode that simplifies LVI method development while maintaining analytical robustness.&nbsp;</p><p>In this work, an Agilent GC/ECD system equipped with MMI was evaluated for the quantitative analysis of 31&nbsp;organochlorine pesticides using two analytical columns <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/library?mainauthorItems=10&amp;search=DB-5ms&amp;sources=GCMS_EN"><strong>DB-5ms</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/library?mainauthorItems=10&amp;sources=GCMS_EN&amp;search=DB-1701"><strong>DB-1701</strong></a>. The use of two columns follows the recommendations of USEPA Method 8081, which requires compound identification based on a primary column to be confirmed on a second column with a different stationary phase to improve analyte identification confidence. Calibration performance, unknown sample quantification, IDL determination, and multiday stability performance were&nbsp;assessed.</p><h4><strong>Conclusion</strong></h4><p>The Agilent GC/ECD system equipped with a Multimode Inlet successfully demonstrated robust quantitative analysis of 31 organochlorine pesticides using large volume injection technology. The solvent vent LVI approach enabled high sensitivity while maintaining good chromatographic performance and excellent reproducibility.&nbsp;</p><h5><strong>Key performance highlights included:&nbsp;</strong></h5><ul><li>Successful dual-column setup meeting EPA 8081 confirmatory identification requirements</li><li>Excellent calibration linearity with R² values greater than&nbsp;0.992&nbsp;</li><li>IDLs of 2.39 ppb or lower for all analytes&nbsp;</li><li>Excellent retention time repeatability with %RSD ≤ 0.07%&nbsp;</li><li>Stable multiday peak area reproducibility with %RSD ≤&nbsp;7.83%&nbsp;</li></ul><p>The combination of Agilent GC/ECD instrumentation, MMI solvent vent technology, and optimized large volume injection workflow provides an effective solution for routine environmental monitoring of organochlorine pesticides.</p><h3><strong>2. LECO: Determination of PFAS in Environmental Waters Using DHS-GCxGC-TOFMS</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/PEGBT_4_D_PFAS_ENVIRONMENTAL_WATER_203_821_721_815a93c9bc.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Per- and polyfluoroalkyl substances (PFAS) represent a vast group of synthetic organic compounds, with over 15,000 known variants. Their structure, characterized by strong carbon-fluorine bonds and amphipathic properties, makes them highly resistant to chemical 1 and biological degradation. These unique features led to extensive industrial and domestic applications, including coatings, 1 textiles, firefighting foams, packaging, and cosmetics. However, their persistence and mobility in the environment, along with their bioaccumulative nature, have raised serious health and ecological concerns. PFAS have been detected in human blood, breast milk, and umbilical cords, and studies since the 2000s have linked them to cancer, immune dysfunction, and endocrine 2 disruption.&nbsp;</p><p>Their recognition as persistent organic pollutants (POPs) under the Stockholm Convention in 2001 has prompted global efforts 3 to limit their release. Yet treating PFAS-contaminated water remains challenging, particularly for short-chain congeners that are not included in conventional removal methods. Monitoring is further complicated by their low concentrations and the interference of complex sample matrices. In addition, traditional sample preparation techniques like liquid-liquid extraction 4,5 (LLE) and solid-phase extraction (SPE) are laborious, solvent intensive, and prone to contamination. In this context, the use of thermal desorption tubes (TDTs) is well suited for trace-level compounds. They enable effective preconcentration while 6 minimizing solvent use and sample handling, reducing the risk of contamination.&nbsp;</p><p>This research aimed to leverage dynamic headspace extraction (DHS) combined with thermal desorption as an alternative for the extraction of volatile and semi-volatile PFAS in water samples. Advanced analytical techniques such as gas chromatography coupled to time-of-flight mass spectrometry (GC-TOFMS) and comprehensive two-dimensional gas chromatography (GCxGC)-TOFMS were used to enhance resolution, sensitivity, and selectivity.</p><h4><strong>Experimental</strong></h4><p>Both GC-TOFMS and GCxGC-TOFMS analyses were performed on a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/37"><strong>Pegasus BT 4D GCxGC-TOFMS system</strong></a> (LECO Corporation, MI, USA) equipped with an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/library?mainauthorItems=10&amp;search=8890&amp;sources=GCMS_EN"><strong>Agilent 8890 GC</strong></a> and an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/library?mainauthorItems=15&amp;search=RTC-PAL&amp;sources=GCMS_EN"><strong>RTC-PAL autosampler</strong></a> capable of automated handling of desorption tubes by employing a Capping/Decapping tool from GL Sciences (Eindhoven, The Netherlands). Sample injections were carried out using an Optic-4 multimode inlet (GL Science, Eindhoven, The Netherlands) with Peltier cooler and a liner exchanger (i.e., LINEX). The GC system was also equipped with a cryogenic trap, used for the secondary trapping/release stage. ® 7 The instrument parameters are summarized in Table 1. Data were acquired and processed using <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/41"><strong>ChromaTOF software</strong></a>.</p><h4><strong>Conclusions&nbsp;</strong></h4><p>The use of dynamic head-space extraction and thermal-desorption GC(xGC)-TOFMS using the LECO Pegasus BT 4D enabled the determination of nine volatile PFAS targets, including fluorotelomer alcohols, acrylates, and alkyl sulfonamides. The method achieved sensitive and precise quantification, with LOQs down to 6.6 ng L⁻¹ and repeatability between 1.4-7.9% RSD. When compared with 1D GC, the enhanced sensitivity of GCxGC allowed reliable detection of PFAS even at much lower concentrations. Moreover, the superior separation power of GCxGC supported effective non-target screening, enabling the identification of additional environmentally relevant compounds in an industrial water case study.&nbsp;</p><p>The combination of DHS-TD with GC-TOFMS, and particularly with GCxGC, provides a versatile platform that ensures robust quantification, high sensitivity, and expanded capabilities for both targeted PFAS analysis and non-targeted screening, supporting its application in environmental monitoring. Given the presence of hundreds of molecules, many of which are still poorly known and characterized, future studies will extend the workflow by including GC(xGC)-HRMS, which represents an important step toward a more comprehensive characterization of this emerging class of (semi-)volatile contaminants and will support the discovery of unknown congeners.</p><h3><strong>3. Shimadzu: Analysis of Methyl Ethane Sulfonate in Nintedanib Esylate API Sample Using Headspace-Trap Technique</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_06_sip_gc_045_en_423dc17c28.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>Shimadzu GCMS-TQ8050 NX with HS-20 NX autosampler works with LabSolutions GCMS 21CFR compliant software which extendsits utilization in compliance environment like pharmaceuticals</li><li>Trap headspace enables concentrating the analytes in cold trap with multi-injection count and helps to achieve higher sensitivity overstatic headspace, especially for trace level quantitation</li></ul><p><strong>Overview: </strong>Alkyl and aryl sulfonic acids have been used in the synthesis of active pharmaceutical ingredients (APIs) in various measures. They are known for their acid catalytic properties, sulfonamide intermediates and as agents to enhance solubility through salt formation. However, as the reactions progress, they form their respective esters, which are well-known potent genotoxic impurities (GTIs), that act as DNA-alkylating agents in biological systems posing mutagenic and carcinogenic risks even at trace levels. Hence, it is necessary to categorize, qualify, and control these impurities to limit the potential carcinogenic risks, as mentioned in ICH M7(R2).&nbsp;</p><p>Nintedanib Esylate API belongs to a family of kinase inhibitors, used primarily to treat idiopathic pulmonary fibrosis (IPF). It acts as a triple angiokinase inhibitor which targets receptors involved in pulmonary fibrosis. The synthesis of the API often involves the reaction of Nintedanib free base with Ethane Sulfonic Acid in a process called as salification. The salt formed in the form of yellow crystals is used further in formulations to enhance stability as well as solubility. The by-product of this reaction, often due to presence of residual short-chain alcohols, is Methyl Ethane Sulfonate (MES).</p><p>As per the ICH M7(R2) guidelines, a TTC (Threshold of Toxicological Concern) based acceptable intake of a mutagenic impurity of 1.5 μg/day which can be used for most pharmaceuticals as a default value, to derive an acceptable limit for control [2,3]. Nintedanib Esylate is supposed to be administered orally. Strength of the Nintedanib Esylate API in most of the medicines is 150 mg per capsule and prescribed dose is twice in a day. [4]</p><p>Irrespective of the limit calculated from maximum daily dose, Shimadzu has worked upon developing a method for quantification of MES at lowest possible detection so that it will be beneficial for the concern pharmaceuticals even if daily dose exceeds 0.3 g/day.</p><h4><strong>Need for a robust analytical method&nbsp;</strong></h4><p>Nintedanib Esylate API shows high solubility in acidic pH of about 3. To inject acidic aqueous media into GC via direct injection technique creates the risk of very high vapor pressure at the injector port. Further, its entry into the column might affect the stationary phase, thereby drastically reducing the shelf-life of the column. As a result, sensitivity of the analytical method becomes questionable. In order to overcome the said issues, it is imperative to develop a robust analytical method pertaining to high sensitivity, repeatability and reproducibility of the results.</p><p>In this regard, <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=1&amp;search=8050"><strong>Shimadzu GCMS-TQ8050 NX triple quadrupole</strong></a><strong> </strong>system with <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=1&amp;search=HS-20+NX"><strong>HS-20 NX</strong></a> (Trap) as shown in Figure 2, was used to develop a selective and sensitive method for the determination of Methyl Ethane Sulfonate in Nintedanib Esylate API at trace levels.&nbsp;</p><p>Further, development and partial validation were performed at significantly lower concentrations which clearly evidences the capability of instrument and suitability of the developed method.&nbsp;</p><p>To evaluate the method suitability, few validation parameters were performed such as system suitability, LOQ precision, Linearity and accuracy in terms of spike recovery. Refer Table 1 for the concentration levels of method validation parameters.</p><h4><strong>Conclusion&nbsp;</strong></h4><ul><li>Shimadzu GCMS-TQ8050 NX with HS-20 NX (Trap) autosampler enables accurate quantification of Methyl Ethane Sulfonate in Nintedanib Esylate API sample at ppb level.&nbsp;</li><li>Trap mode in the HS-20 NX auto sampler benefits in extracting the analyte multiple times which enhances sensitivity</li></ul></div></div></div></div></div></div></section>

News from LabRulezGCMS Library - Week 40, 2026

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 29th September 2026? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you technical note by <strong>KNAUER,</strong> application note by <strong>Shimadzu </strong>and posters by<strong> Thermo Fisher Scientific / HPLC Symposium </strong>and <strong>Waters Corporation / AOAC!</strong></p><h3><strong>1. KNAUER: Efficient separation of di(2-ethylhexyl) phthalate (DEHP) from oil matrices using GPC</strong></h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/VTN_00_XX_knauer_applichrom_gpc_f1d7f1a236.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Phthalates are chemical compounds primarily used as plasticizers in polymers to enhance the flexibility and elasticity of materials such as polyvinyl chloride (PVC) [1]. Since plasticizers are not covalently bound to the polymer chains, they have the potential to leach into the contacting media and contribute to contamination [2]. With the widespread and increasing use of plastic materials, the risk of phthalate release and human exposure continues to rise. As a result, and due to their potentially harmful effects on human health, phthalates have attracted growing scientific and regulatory attention in recent years [1]. Oil-rich food products can leach lipophilic phthalates from their packaging [3]. Throughout the production and packaging process, polymeric components such as tubing, containers, and caps may serve as potential sources of contamination. For the analysis of phthalates in such oil matrices, sample cleanup is an essential step. Gel permeation chromatography (GPC), based on sizeexclusion principles, is widely applied as an effective cleanup technique prior to subsequent analytical determination.</p><h4><strong>MATERIALS &amp; METHODS</strong></h4><p>The samples were dissolved in the eluent mixture and filtered through a 0.45 µm PTFE filter prior to analysis. For both olive oil and canola oil, an additional sample spiked with DEHP was prepared and likewise filtered before analysis. Chromatographic analysis was performed using an isocratic method with an eluent composition of ethyl acetate/heptane (50:50 v/v) at a flow rate of 1.0 mL/min. Detection was carried out by UV absorbance at 254 nm. The injection volume was 8 µL using a full-loop injection mode. The column temperature was maintained at 25°C. Separation was achieved on an <strong>AppliChrom® OleoSep column </strong>(10 µm, 300 × 8 mm). The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1630"><strong>AZURA® Semi Preparative GPC System</strong></a> was used.</p><h4><strong>CONCLUSION</strong></h4><p>GPC sample preparation is an effective approach for separating phthalates from high-molecular-weight matrices such as edible oils. In this study, the successful separation of di(2-ethylhexyl) phthalate (DEHP) from three different oil samples was demonstrated. Based on these results, it can be assumed that other phthalates with lower molecular weights (&lt; 390 Da) can also be effectively separated under same conditions. The KNAUER AZURA® GPC semi preparative system (Fig. 4) in combination with the AppliChrom® OleoSep GPC column provides a robust and efficient setup for sample preparation in phthalate analysis, offering rapid separation, high resolution, and minimal solvent consumption due to the short analysis time.</p><h3><strong>2. Shimadzu: Analysis of Chloride and Sulfate Ions in Bioethanol Using the </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=1&amp;search=Nexera+IC"><strong>Nexera IC Ion Chromatograph</strong></a></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_01_01211_en_55cbf3e64f.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>Analysis of chloride and sulfate ions in fuel ethanol can be conducted in accordance with ASTM D7319-221) .</li><li>Accurate quantitative determination, exhibiting excellent linearity and repeatability, can be achieved at concentration levels significantly below the limits specified by the ASTM criteria.</li></ul><p>First-generation bioethanol produced from raw materials such as corn and sugarcane has been utilized to achieve carbon neutrality. However, research and development for second-generation bioethanol produced from non-food, cellulose-based raw materials is also underway to avoid competition with food crops. In Japan, eight companies, including Toyota Motor Corporation, have formed the “Research Association of Biomass Innovation for Next Generation Automobile Fuels” (raBit) to advance research on next-generation bioethanol technologies. Shimadzu participates as a supporting member and promotes research and development through analytical technology cooperation.</p><p>&nbsp;It is known that the presence of chloride and sulfate ions in fuel ethanol can form engine residue, leading to reduced engine performance. ASTM D4806-252) specifies fuel ethanol quality as criterion of chloride ion must not exceed 6.7 mg/kg and that of sulfate ion must not exceed 4 mg/kg. ASTM D7319-22 includes test methods for chloride and sulfate ions in fuel ethanol using ion chromatography.&nbsp;</p><p>In this application, we present an example of the analysis of chloride and sulfate ions in bioethanol using the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=1&amp;search=Nexera+IC"><strong>Nexera IC</strong></a> in accordance with ASTM D7319-22.</p><h4><strong>Conclusion</strong></h4><p>Chloride and sulfate ions in bioethanol were determined using a Nexera IC system in accordance with ASTM D7319-22. The method offers high sensitivity, linearity, and repeatability, enabling reliable quantification at concentrations well below ASTM-specified limits, thus supporting effective quality control and regulatory compliance of fuel ethanol.</p><h3><strong>3. Thermo Fisher Scientific / HPLC Symposium: LC-MS analysis of intact and subunit-level mAb enabled by a novel monodisperse supermacroporous reversed-phase platform</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/po_004763_ccs_surepac_protein_reverse_phase_mabs_separation_po004763_na_en_56199ec50d.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Monoclonal antibodies (mAbs) are structurally complex biotherapeutics that require multi-level analytical characterization to ensure product quality, safety, and efficacy. LC-MS analysis is routinely applied at the intact protein and subunit levels to assess molecular mass, heterogeneity, and structural integrity. Enzymatic subunit generation, such as IdeS digestion, enables targeted domain-level characterization while reducing analytical complexity compared to full peptide mapping. Achieving high-performance reversed-phase separations across intact and subunit-level workflows remains challenging, as chromatographic columns optimized for intact proteins often compromise performance of smaller subunits. Consequently, multiple columns are required to support comprehensive mAb characterization.&nbsp;</p><p>In this study, we evaluate a reversed-phase separation column based on a novel 2.5 μm monodisperse supermacroporous (SMP) polymeric stationary phase for unified LC-MS analysis of monoclonal antibodies under intact, reduced, and IdeSdigested conditions. The SMP resin’s uniform particle size and highly accessible pore structure enable efficient separation of both small and large analytes, including intact mAbs, reduced subunits (LC and HC), and IdeS-generated fragments such as scFc and F(ab′)₂. Using the SurePac Protein RP MDi column, baseline separation of these species was achieved within a 10- minute gradient, providing a fast, all-in-one LC-MS approach for mAb variant characterization.</p><h4><strong>Materials and methods</strong></h4><h5><strong>Instruments&nbsp;</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/744"><strong>Thermo Scientific Vanquish Horizon UHPLC system</strong></a>; <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/401"><strong>Thermo Scientific Orbitrap Exploris 480 mass spectrometer</strong></a> with <strong>Thermo Scientific OptaMax NG ion source</strong>.&nbsp;</p><h5><strong>Data analysis&nbsp;</strong></h5><p>The UHPLC system with mass spectrometer were operated with <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1758"><strong>Thermo Scientific Xcalibur 4.7 software</strong></a>. Full MS spectra of intact mAbs and mAb fragments were analyzed using Thermo Scientific Freestyle 1.8 and BioPharma Finder 5.4 software that utilizes the ReSpect and Xtract algorithms for molecular mass determination.</p><h4><strong>Conclusions&nbsp;</strong></h4><ul><li>A SurePac Protein RP column enabled a rapid (10 min) separation of mAb LC, HC, scFc, and F(ab′)₂ fragments, with major proteoforms identified by mass agreement.&nbsp;</li><li>The SurePac Protein RP column supports comprehensive intact and subunit-level mAb characterization in a single workflow, with strong separation performance across mAb fragments.</li></ul><h3><strong>4. Waters Corporation / AOAC: IMPROVED PURIFICATION OUTCOMES FOR PROBLEMATIC COMPOUNDS USING AN INERT COLUMN WITH POLAR SORBENT</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/720009616_AOAC_f65ea1b771.pdf"><strong>Full PDF for download</strong></a></li></ul><div><div><section><div><div><div><div><div><div><p>Whether the goal is to obtain enough intermediate for the next step in a synthetic scheme, to polish a final product, or to create a suitable standard for compound identification, preparative liquid chromatography remains a primary technique for isolating compounds from complex mixtures. Recovering the target compound at the desired purity and yield in the least amount of time is of utmost importance.&nbsp;</p><p>Polar targets that do not retain, or “sticky” compounds that seemingly disappear on the column are two groups that many consider to be ’problematic’ in purification. “Sticky” compounds, also known as non-specific adsorbers (NSAs), are metal-sensitive targets what can adsorb to positively charged metal surfaces in the LC system flow path and column, making them difficult to detect and collect effectively. Although other methods, such as column pre-conditioning, can be implemented for isolating compounds known to be interactive, this option can be time-consuming and lead to sample loss and excessive solvent waste.&nbsp;</p><p>Although lab scale purifications in which tens to hundreds of milligrams of target compound are isolated from crude mixtures are still performed routinely, the trend toward smaller scale purification is becoming more prevalent. Laboratories are increasingly opting to isolate only a few milligrams of target compound for preliminary studies. Successful target candidates are then isolated in greater amounts to satisfy ensuing experiments. Whether the objective is to isolate a small amount of target compound for exploratory studies, or to purify greater amounts for their use as reference standards, a column which can resolve eluting impurities efficiently is required.&nbsp;</p><p>Echinacea is an herbaceous flowering plant in the daisy family<sup>1,2</sup> and is one of the most important medical herbs widely used to treat the common cold and other infectious diseases.<sup>3</sup> One of the most abundant compounds in echinacea is chicoric acid (Figure 1), a phenylpropanoid and caffeic acid derivative.<sup>4,5</sup> In this scale-up study, chicoric acid, a suspected “sticky” target polar compound was isolated from a complex echinacea tea extract using two inert XSelect HSS T3 MaxPeak Premier OBD Columns with different particle sizes and dimensions (3.5 μm 10 x 100 mm and 5 μm 10 x 150 mm). The MaxPeak Premier OBD preparative HPLC columns are considered ’inert’ because they are enabled with Waters High Performance Surface (HPS) Technology. The chicoric acid isolated using the 3.5 μm column was of equivalent UV purity to the product isolated using the 5 μm column, with a 34% savings in run time. Smaller particle preparative isolations using columns with inert hardware are a practical option for those laboratories where reduced amounts of target are needed for projects conducted on accelerated timelines.</p><h4><strong>METHODS</strong></h4><ul><li><strong>Analytical Columns and flow rate:</strong> ACQUITY Premier HSS T3 and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1952"><strong>ACQUITY UPLC HSS T3 Columns</strong></a>; 1.8 μm, 2.1x50 mm; 0.35 mL/min&nbsp;</li><li><strong>Prep Columns and flow rate:</strong> XSelect HSS T3 OBD Prep Column and XSelect Premier HSS T3 OBD Prep (custom) Columns, 5 μm, 10x150 mm; XSelect Premier HSS T3 OBD Prep Column, 3.5 μm, 10x100 mm; 5.4 mL/min</li></ul><h5><strong>Instrumentation&nbsp;</strong></h5><ul><li><strong>Analytical:</strong> <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/198"><strong>ACQUITY UPLC H-Class System</strong></a>; Quaternary Solvent Manager, Sample Manager FTN-H, Column Manager, TUV Detector, <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1543"><strong>ACQUITY QDa Detector&nbsp;</strong></a></li><li><strong>Prep:</strong> Waters AutoPurification System; 2545 Binary Gradient Module, 2767 Sample Manager, System Fluidics Organizer, 2998 Photodiode Array Detector</li></ul><h4><strong>CONCLUSIONS&nbsp;</strong></h4><ul><li>Chicoric acid was analyzed and isolated using analytical and preparative MaxPeak Premier HSS T3 Columns with inert surfaces, which increased the peak area and height for improved detection and collection.&nbsp;</li><li>Chicoric acid was successfully isolated using 3.5 and 5 μm XSelect Premier HSS T3 OBD Prep Columns and fraction pool analysis showed equivalent UV purity, which suggests the viability of incorporating small particle preparative chromatography into the purification workflow.&nbsp;</li><li>3.5 μm preparative columns improve purification process efficiency and promote sustainability by reducing method run time, solvent usage, and fraction lyophilization time.&nbsp;</li><li>Inert MaxPeak Premier column hardware, OBD Technology, and small particle preparative columns are well-suited for the demands of the purification laboratory when results must be generated efficiently to satisfy accelerated production timelines</li></ul></div></div></div></div></div></div></section></div></div>

News from LabRulezLCMS Library - Week 40, 2026

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 29th September 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies, LECO,</strong> <strong>Shimadzu</strong> and <strong>Thermo Fisher Scientific!</strong></p><h3><strong>1. Agilent Technologies: Analysis of Environmental Waters by ICP-QQQ with a Dual-Cell System and Discrete Sampling</strong></h3><p><strong>Fast, accurate measurements by the </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=9500"><strong>Agilent 9500 ICP-QQQ </strong></a><strong>in Advanced Helium Mode</strong></p><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_enviro_waters_DCS_9500_icp_qqq_5994_9125en_agilent_590880266a.pdf"><strong>Full PDF for download</strong></a><strong>&nbsp;</strong></li></ul><p>Agilent ICP-MS instrumentation has become standard equipment in many environmental laboratories, recognized for its speed, sensitivity, accuracy, and robustness. Its ability to integrate seamlessly with autosamplers, high‑speed discrete sampling systems, and autodilutors has further contributed to its widespread adoption.<sup>1–3</sup> These capabilities are especially important in contract environmental laboratories, where increasing competition and financial pressures have made sample throughput and productivity a top priority. At the same time, laboratories are expected to process more samples in less time, without sacrificing data quality or ease-of-use. To address these demands, the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=9500"><strong>Agilent 9500 Triple Quadrupole ICP-MS</strong></a> (ICP-QQQ) includes a unique Dual-Cell System (DCS) collision/reaction cell (CRC). For routine testing of large numbers of samples, the DCS can be operated in Advanced Helium Mode (AHM), a revolutionary collision-cell mode that delivers excellent-quality data across a wide range of analytes.</p><p>AHM delivers high‑sensitivity measurements while effectively removing interferences through a dual mechanism of collision‑induced dissociation (CID) and kinetic energy discrimination (KED), eliminating the need for multiple cell conditions.&nbsp;</p><h5><strong>AHM: A revolution in helium-based interference removal&nbsp;</strong></h5><p>AHM represents a major advancement in He-KED collision-cell technology by dynamically optimizing DCS conditions for both low- and high-mass elements in real time. As a result, AHM provides an approximately 20-fold improvement in sensitivity for low-mass elements and approximately a twofold improvement for mid- to high-mass elements. By enabling interference removal across the entire periodic table in a single gas mode, AHM replaces no gas, conventional He, and high energy (HE) He mode. Eliminating cell‑gas switching simplifies the workflow and accelerates sample measurement using the 9500 ICP-QQQ with DCS.&nbsp;</p><p>As shown in Figure 1, the DCS incorporates a two-stage ion guide design (front and rear ion guides) and rapid cell voltage control. These features underpin the improved performance of AHM relative to conventional He-KED mode. Further technical details of the DCS and AHM are described elsewhere.<sup>4</sup></p><h5><strong>AVS MS discrete sampling: Maximizing sample throughput and minimizing maintenance&nbsp;</strong></h5><p>The 9500 ICP-QQQ can also be fitted with the optional Agilent AVS MS discrete sampling accessory, which is ideal for high-throughput applications. The AVS&nbsp;MS minimizes both sample delivery and rinsing times, significantly accelerating the analytical cycle. When combined with AHM, the 9500 with AVS MS reduces both the analysis time per sample and the interface’s exposure to the complex sample matrices common in environmental samples.</p><p>The AVS MS is an automated multi-port switching valve system that directs sample and rinse solutions through different flow paths.<sup>1,2</sup> It introduces sample to the ICP-MS only during data acquisition, while a clean blank solution is nebulized at all other times. This approach not only increases sample throughput but also reduces the amount of sample that reaches the instrument, resulting in lower cleaning requirements and improved long-term stability.&nbsp;</p><p>By combining AVS MS discrete sampling and a single AHM collision cell mode for all elements, laboratories can achieve higher sample throughput and lower maintenance frequency, ultimately reducing operating costs and improving margins.&nbsp;</p><p>In this study, certified reference materials (CRMs) representative of the routine workload in contract environmental laboratories were analyzed by the 9500 ICP-QQQ to assess accuracy, productivity, and long‑term stability.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>The study showed that the Agilent 9500 ICP-QQQ with Dual-Cell System (DCS) operating in Advanced Helium Mode (AHM) and equipped with an integrated AVS MS discrete sampler delivered exceptional performance for routine environmental analyses.&nbsp;</p><p>Over 140 samples, including real-world environmental water samples, were analyzed in under 140&nbsp;minutes, with no need for matrix matching the calibration standards or recalibration. The 9500 ICP-QQQ workflow delivered a 50% increase in sample throughput compared with a comparable single‑quad ICP‑MS method, substantially improving overall productivity.&nbsp;</p><p>The method’s accuracy was confirmed through multiple measurements of water, soil, and sediment CRMs. Each sample was analyzed in under one minute, highlighting the method’s capacity for high‑throughput analysis while maintaining accuracy, as demonstrated by recoveries within 100 ± 10%. The long-term stability test results confirmed the robust performance of the 9500 ICP-QQQ with UHMI and AVS&nbsp;MS for the analysis of high-TDS samples, with no internal standard failures over more than two hours.&nbsp;</p><p>The results confirm fast analysis, effective interference removal, and robust, stable performance during the analysis of high‑matrix samples over long runs—all critical performance criteria for demanding environmental workflows.&nbsp;</p><p>In an increasingly competitive landscape, where environmental laboratories are under pressure to improve productivity without compromising data quality, the 9500 ICP-QQQ controlled by Agilent OpenLab ICP-MS software operating in a single gas cell mode offers a powerful solution. AHM streamlines analytical workflows, reduces instrument maintenance demands, and delivers robust, reproducible results, enhancing overall operational efficiency.</p><h3><strong>2. LECO: Temperature-Dependent Determination of Total Carbon (TC), Total Organic Carbon (TOC), Residual Oxidizable Carbon (ROC), and Total Inorganic Carbon (TIC) in Soil</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/CM_812_TC_TOC_TIC_ROC_SOIL_203_821_728_4773eacc8f.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Total organic carbon (TOC) analysis is a widely used indicator of soil quality in agricultural and ecological systems. Because TOC reflects the amount of carbon stored in soil organic matter, it serves as a strong measure of soil health, fertility, and its capacity to sequester atmospheric carbon. Organic carbon supports essential soil functions, including microbial activity, nutrient cycling, and soil aggregation, which in turn improves water-holding capacity, reduces erosion, and strengthens the resilience of cropping systems. These qualities are especially important in regenerative agriculture, where restoring ecosystem function is a central goal. TOC measurements are also valuable for evaluating the impact of management practices such as crop rotation, cover cropping, reduced tillage, and the application of compost or manure. By tracking TOC levels, growers can optimize soil amendment strategies to build organic matter effectively without excessive application.&nbsp;</p><p>Residual oxidizable carbon (ROC) is the portion of soil organic carbon that is more stable than actively cycling carbon, yet can still be oxidized through chemical or thermal processes, typically at temperatures between 400–600 °C. Unlike biologically active carbon pools, ROC represents a long-lasting, non-bioavailable carbon reserve made up of materials such as charcoal, biochar, lignin, humus, and graphite. Because these carbon forms decompose slowly, they contribute to durable soil structure, improved nutrient retention, and gradual carbon release. Measuring ROC provides insight into the stability of soil carbon and helps differentiate persistent carbon from rapidly degradable fractions. By comparing ROC to TOC, growers can estimate how much of the soil organic carbon is readily available for biological processes versus how much of it contributes to long-term carbon sequestration.</p><h4><strong>Instrument Model and Configuration&nbsp;</strong></h4><p>The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=24&amp;search=CM812"><strong>LECO CM812</strong></a> is a multiphase carbon and moisture determinator with a variable ramp furnace and a wide carbon detection range that is specifically designed to differentiate various forms of carbon by the temperature at which they combust. This capability facilitates the temperature differentiation determination of the different species of carbon in soil.</p><h4><strong>Typical Data&nbsp;</strong></h4><p>The low carbon calibration was performed utilizing a linear, force through origin calibration using LECO 502-696 (Lot 1005) Synthetic Carbon LCRM (1.01 % C). The high carbon calibration was performed utilizing a linear, full regression calibration using LECO 502-696 (Lot 1005) Synthetic Carbon LCRM (1.01 % C) and LECO 502-905 (Lot 1002) Synthetic Carbon LCRM (5.00 % C). The calibrations were verified using LECO 502-934 (Lot 1002) Synthetic Carbon LCRM (0.53 % C) and a reduced sample mass of LECO 502-905 (Lot 1002) Synthetic Carbon LCRM (5.00 % C). The results are reported on a dry basis.</p><h3><strong>3. Shimadzu: Trace Elements Analysis in Steel by ICP-MS</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_01_01207_en_618679c078.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>Even high-matrix metal samples can be analyzed using the Aerosol Dilution System.&nbsp;</li><li>Trace elements in steel can be analyzed simultaneously under a single He collision mode, reducing analysis time.&nbsp;</li><li>Operating costs can be reduced by using a mini torch, which reduces argon consumption.</li></ul><p>In high-performance metallic materials such as steel, material properties are strongly influenced by trace element concentrations, making their proper control extremely important. Conventionally, inductively coupled plasma atomic emission spectrometry (ICP-AES) has been widely used for trace element analysis in metallic materials. In Japan, steel samples have been controlled and analyzed based on JIS G 12011) and JIS G 1258. 2) Recently, however, as metallic materials have become increasingly sophisticated, there has been a growing need to control elements at concentrations below those that can be addressed by conventional methods.</p><p>Inductively coupled plasma mass spectrometry (ICP-MS) is known as a highly sensitive technique for trace element analysis, but in the past it was not always suitable for analyzing high-matrix samples such as metals. In recent years, however, improvements in sample introduction systems, including gas dilution technology, have made it possible to apply ICP-MS to high-matrix samples as well.&nbsp;</p><p>This article describes the trace element analysis of certified reference materials for steel using the Aerosol Dilution System installed as standard in the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=1&amp;search=ICPMS-2050"><strong>ICPMS-2050</strong></a> (Fig. 1). By reducing the amount of sample introduced into the plasma through gas dilution, matrix-induced decreases in signal intensity and signal drift could be effectively suppressed, enabling stable analytical results. The results are presented below.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>In this application news article, trace elements in a certified reference material for steel were analyzed using the<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=1&amp;search=ICPMS-2040%2F2050"><strong> ICPMS2040/2050</strong></a>. Agreement with the certified values confirmed the accuracy of the analytical results. In addition, for the elements analyzed in this study, simultaneous analysis under a single condition was possible without changing the cell conditions, thereby reducing the analysis time. By using a mini torch, the ICPMS-2040/2050 reduces argon gas consumption while enabling stable analysis of high-matrix metal samples such as steel.</p><h3><strong>4. Thermo Fisher Scientific: Unbiased Color Analysis using UV-Visible Spectrophotometers</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/unbiased_color_analysis_using_uv_visible_spectrophotometers_an1406_en_b2893661ee.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Across a range of different applications, the color of a material can be an important quality assessment. For certain environments, like textiles and paint manufacturers, the color must match an established criteria to ensure product consistency. In other areas, like water analysis and pharmaceutical manufacturing,¹- ⁴ the color of a product may indicate the presence of undesired substances. While the specific areas of study can vary greatly, the ability to rigorously assess a given sample’s color is shared among these application spaces. Visual methods for determining color have been used in many of these industries; however, technician-to-technician biases inherently influence the analysis. This can lead to discrepancies between testing subjects and testing sites. As a result, it is often preferred to use an unbiased instrument-based method for precisely determining the color of a given product or sample.&nbsp;</p><p>The human eye is able to collect the light reflected off a surface, leading to the perception of color. Since the color range we can see covers the aptly named visible range of the electromagnetic spectrum (400 – 700 nm), UV-Visible spectrophotometers are often used for color analysis. These instruments are used to assess a material’s response to light in the ultraviolet (UV) and visible spectral range. Based on the electronic structure of the material, light within this range is either absorbed, transmitted, or reflected off the material of interest. Given that color perception is based on the collected reflections from a material’s surface, UV-Visible spectroscopy is an ideal technique for this analysis.&nbsp;</p><p>Once the visible spectrum of a given sample, either in liquid or solid form, is collected, there are a number of unique analysis methods that can be used to report the color. As there are many different industries which require this analysis, a multitude of different standardized methods exist which call for different color analysis procedures. Herein, a selection of these standard color analyses is detailed, and information pertaining to the industry standards required for these analyses are discussed. For these methods, special attention is focused on the use of UV-Visible techniques.</p><h4><strong>Summary&nbsp;</strong></h4><p>The color of a finished product can have implications on the quality, both in terms of the appearance and the presence of degraded materials or contaminants. As shown herein, there exist many standardized methods for ascertaining the color of a given substance. While visual methods can be applied, the use of a UV-Visible spectrophotometer is widely accepted and is helpful in providing an unbiased technique for color analysis.</p>

News from LabRulezICPMS Library - Week 40, 2026

News from LabRulezGCMS Library - Week 41, 2026

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 5th October 2026? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Metrohm </strong>and posters by <strong>Shimadzu / ASMS, Thermo Fisher Scientific / Metabolomics </strong>and <strong>Waters Corporation / ASMS!</strong></p><h3><strong>1. Metrohm: Carbonate in lithium carbonate by potentiometric titration</strong></h3><p><strong>Determination of carbonate in lithium carbonate by potentiometric titration according to draft standard ISO 10662</strong></p><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_t_251_download_c1c530d784.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Lithium carbonate is one of the main lithium salts in cathode materials used for lithium-ion batteries. Accurate carbonate and overall purity determination in this raw material are essential because even trace impurities can affect key physicochemical properties, ultimately influencing electrochemical behavior in downstream applications. This is especially significant in battery-grade materials, where strict compositional tolerances are required to ensure consistent manufacturing performance, long-term cell stability, and overall safety. This Application Note describes carbonate content determination in lithium carbonate on an automated OMNIS system with Dis-Cover lids. The ISO 10662 draft method quantifies the main content of lithium carbonate to enable a precise assessment of material purity.</p><h4><strong>EXPERIMENTAL</strong></h4><p>The analysis is carried out on an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=220&amp;search=OMNIS+Titrator"><strong>OMNIS Advanced Titrator</strong> </a>with an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=220&amp;search=OMNIS+Sample+Robot"><strong>OMNIS Sample Robot</strong></a> equipped with a dUnitrode and Dis-Cover lids (Figure 1). A blank analysis is performed with a start volume of hydrochloric acid and titrated until after the equivalence point. Samples are titrated with hydrochloric acid until after the second equivalence point.</p><h4><strong>CONCLUSION</strong></h4><p>The OMNIS Titrator and OMNIS Sample Robot with Dis-Cover lids provide a fast and reliable determination of carbonate in lithium carbonate according to draft standard ISO 10662. The OMNIS system can be expanded to other titration applications as required.</p><h3><strong>2. Shimadzu / ASMS: Comprehensive Untargeted Metabolomic Analysis from Five Stages of Blueberry Development by High Resolution Accurate Mass Spectrometry</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/MP_459_Comprehensive_Untargeted_Metabolomic_Analysis_from_Five_Stages_of_Blueberry_Development_by_High_Resolution_Accurate_Mass_Spectrometry_bc0aadf181.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Metabolomic studies of blueberry cultivars and growth stages have been conducted to identify optimal cultivation conditions maximizing antioxidant production. Many of these studies utilize reversed phase (RP) chromatography and target fragmentation data collection at the most abundant chemical species as observed by electrospray ionization mass spectrometry (ESI MS). However, this strategy may miss important metabolites suppressed by matrix effects or unfavorable ionization. A comprehensive untargeted metabolomic study was performed to determine how diverse chromatographic separation and multiple fragmentation strategies could impact the identification of additional metabolites. The expanded metabolomics data was used to assess differences across fruit developmental stages and determine if unique metabolomic populations could be identified between stages.</p><h4><strong>Methods</strong></h4><p>All samples were analyzed in triplicate and in a randomized order using a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=1&amp;search=nexera+hplc"><strong>Nexera HPLC</strong></a> and a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=1&amp;search=9050"><strong>Shimadzu LCMS-9050 Q-TOF</strong></a>. To maximize feature identification across the blueberry developmental stages, both RP and hydrophilic interaction liquid chromatography (HILIC) were used. Mass spectrometry data was collected with ESI in positive and negative mode using data-independent analysis (DIA) and data-dependent analysis (DDA), generating 8 different analytical methods in total.</p><h4><strong>Conclusions</strong></h4><p>The Shimadzu LCMS-9050 provided a comprehensive analysis of plant extracts when complementary chromatographic and MS analysis modes were utilized. All five growth stages showed distinct metabolimic populations. Overall differentiation of groups is captured by any of the analytical methods employed, but the same approach can be used to get a more holistic approach to metabolome coverage. If reduced analysis time is preferred, a combination of HILIC DDA and RP DDA methods characterize most metabolites.</p><h3><strong>3. Thermo Fisher Scientific / Metabolomics: Pushing the limits of structural lipidomics: enhanced sensitivity and MS³-driven annotation on Orbitrap Tribrid Apex Small Molecule MS</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/po_004763_ccs_surepac_protein_reverse_phase_mabs_separation_po004763_na_en_56199ec50d.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Advances in lipidomic analysis require mass spectrometry deliver high sensitivity, rapid acquisition, and efficient parallel use of multiple mass analyzers. Orbitrap Tribrid Apex Small Molecule MS was evaluated to meet these demands through improved sensitivity, faster polarity switching, and enhanced parallelization between the Orbitrap analyzer and linear ion trap analyzer. High-resolution MS enables effective resolution of isobaric lipid species, while alternative fragmentation strategies with rapid MSⁿ, supports confident lipid identification and structural annotation of lipid classes. The parallel operation of the Orbitrap analyzer and linear ion trap analyzer minimizes duty-cycle limitations while maximizing data density and throughput. Leveraging these instrument enhancements, robust lipidomics workflows were demonstrated through method evaluation with lipid reference materials and application to complex biological samples from plants.</p><h4><strong>Materials and methods</strong></h4><p><strong>Instrumentation and methods: </strong>A <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1988"><strong>Thermo Scientific Accucore C30 HPLC Column</strong></a> (150 mm x 2.1 mm, 2.6 µm particle size) connected to a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/744"><strong>Thermo Scientific Vanquish Horizon UHPLC System</strong></a> and a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=3&amp;search=Orbitrap+Tribrid+Apex"><strong>Orbitrap Tribrid Apex Small Molecule MS</strong></a> were used to acquire the data.</p><h4><strong>Conclusions&nbsp;</strong></h4><p>We have successfully demonstrated the utility of the Orbitrap Tribrid Apex Small Molecule MS for structural lipidomics, using various fragmentation strategies on an LC timescale. We applied this to study lipid extracts from a plant and annotated around 1700 high grade lipids.</p><h3><strong>4. Waters Corporation / ASMS: Tandem Quadrupole DESI Imaging To Visualize Spatial Distribution of Gefitinib and Related Metabolites in Rat Liver</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/720009433_4e913e0193.pdf"><strong>Full PDF for download</strong></a></li></ul><div><div><section><div><div><div><div><div><div><p><span>This poster presents a targeted DESI-MS/MS imaging workflow for visualizing the spatial distribution of gefitinib and its metabolites in rat liver after a single therapeutic subcutaneous dose. The study addresses a common limitation in drug-distribution studies: spatial localization is often assessed using radiolabeled compounds, which may not be available during early drug discovery. DESI offers a label-free ambient ionization approach with minimal sample preparation, enabling direct mapping of drugs and metabolites in tissue.</span></p><p><span>Male Wistar rats received gefitinib at 10 mg/kg, while plasma, urine, and liver samples were collected over a 24-hour period. Plasma and urine were analyzed by LC-MS/MS for pharmacokinetics and metabolite identification, whereas fresh-frozen liver sections were analyzed by targeted DESI MRM imaging on a </span><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2100"><span><strong>Xevo TQ-Absolute XR tandem quadrupole mass spectrometer</strong></span></a><span>. Liver sections were cryosectioned to 10 µm thickness and analyzed using DESI with a methanol/water solvent containing formic acid.&nbsp;</span></p><p><span>The targeted DESI imaging experiment detected gefitinib together with six metabolites in liver tissue. Signal intensities were generally highest at approximately 1 hour after dosing, but the compounds remained detectable at 24 hours. Importantly, this was achieved at a therapeutically relevant dose rather than the much higher doses often required for imaging studies. The spatial imaging data also showed good agreement with LC-MS/MS pharmacokinetic profiles, particularly for gefitinib and the M11 metabolite.&nbsp;</span></p><p><span>Overall, the poster demonstrates that tandem quadrupole DESI MRM imaging can complement conventional LC-MS/MS by adding spatial information to quantitative pharmacokinetic and metabolite data. The approach enables label-free mapping of drug distribution directly in tissue and may therefore provide a useful tool for drug metabolism and disposition studies during discovery and development.</span></p></div></div></div></div></div></div></section></div></div>

News from LabRulezLCMS Library - Week 41, 2026

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 5th October 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring you technical note by <strong>Agilent Technologies, </strong>application notes by<strong> LECO </strong>and <strong>Thermo Fisher Scientific </strong>and poster by <strong>Shimadzu / AOAC!</strong></p><h3><strong>1. Agilent Technologies: ATR Sampling Accessories for the </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?instrumentationItems=89&amp;mainauthorItems=10&amp;search=635"><strong>Agilent Cary 635 FTIR</strong></a><strong> Spectrometer</strong></h3><p><strong>An easy and versatile way to perform FTIR measurements</strong></p><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/5991_6858_EN_bcf9447b77.pdf"><strong>Full PDF for download</strong></a><strong>&nbsp;</strong></li></ul><p>Attenuated total reflectance (ATR) is the most widely used sampling methodology for Fourier transform infrared (FTIR) spectroscopy. This popularity is due to its ability to quickly and easily measure a broad range of sample types, including liquids, solids, powders, semisolids, and pastes. The Agilent Cary 635 FTIR spectrometer uses a versatile modular concept, where precisely optimized sampling modules are attached to the front of the Cary 635 FTIR engine. Depending on the specific application or sample, different ATR sensors are used. Permanently aligned optics allow a wide range of modules to be swapped in seconds, with no user alignment. The Cary 635 FTIR accommodates a wide selection of ATR sensors, and features the ability to switch from one ATR sensor to another instantaneously.&nbsp;</p><p>For most applications, single reflection zinc selenide (ZnSe), diamond, and germanium (Ge) ATR sampling modules are available for the Cary 635 FTIR. These modules are used with a sampling press, and are excellent for analyzing solid materials, as well as liquids, pastes, and gels. The diamond sensor is highly durable, and the best choice for harder materials. The ZnSe sensor is a good choice for softer solids. The Ge sensor, with a shorter pathlength, is the best choice for highly absorbing samples. In addition, the multireflection ZnSe ATR sampling module is a great option for the analysis of liquids, pastes, and gels, where extra sensitivity is&nbsp;needed.&nbsp;</p><p>Because these sampling technologies are custom engineered for the Cary 635 FTIR, the analyst can have confidence in the results, whichever ATR sensor is chosen for their application. This custom engineering translates into the highest performance, sensitivity, and ease-of-use of any spectrometer in its class.</p><h4><strong>ATR sensors for the </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?instrumentationItems=89&amp;mainauthorItems=10&amp;search=635"><strong>Cary 635 FTIR&nbsp;</strong></a></h4><p>Whether your applications require the single reflection ZnSe, diamond or Ge, or the multireflection ZnSe, the Cary 635 FTIR delivers class-leading performance. Unlike other FTIR spectrometers that use third-party accessories, sampling technology for the Cary 635 FTIR is custom designed by Agilent engineers, and perfectly matched to the optical characteristics of the spectrometer. The rugged, no‑alignment design permits instantaneous exchange of these ATR sampling technologies, so that any sample type you might face will readily be accommodated.&nbsp;</p><h5><strong>Zinc selenide (ZnSe) ATR modules&nbsp;</strong></h5><p>ZnSe is a semiconductor-type material that has been used for many years as an ATR sensing element. It is relatively hard, has a broad wavelength range, and is insoluble in water. For this reason, it is an excellent choice for pliable solids, pastes, gels, and liquids. It can be used to analyze aqueous solutions in the pH 5 to 9 range. The Cary 635 FTIR has two variations of ZnSe sampling technology available: multireflection and single reflection sensors.&nbsp;</p><h5><strong>Single reflection ZnSe ATR module&nbsp;</strong></h5><p>Because of the relatively short pathlength of infrared light into the sample, this sensor is ideal for neat samples; that is, samples that are relatively concentrated or pure. The single reflection ZnSe module is a good choice for identification of softer materials, as well as viscous liquids. When measuring solids, such as polymer films, it can be used with the Cary 635 FTIR.&nbsp;</p><h5><strong>Multireflection ZnSe ATR module&nbsp;</strong></h5><p>The exceptional performance of the Cary 635 FTIR, combined with the increased pathlength of the multireflection ATR sensor, demonstrates a spectrometer system of unsurpassed sensitivity. Lower concentration components in pastes, gels and liquids can be measured. Solutes in diluted or concentrated aqueous solutions in the pH range of 5 to 9 can also be analyzed. Since the multireflection sensor is recessed slightly in its stainless steel holder, it is ideal for analyzing nonviscous liquid samples. This sensor is a superior choice when qualitative or quantitative measurements are required. It is not recommended for use with solid materials, since it is not used with the pressure clamp.&nbsp;</p><h3><strong>2. LECO: Temperature-Dependent Determination of Total Organic Carbon (TOC) in Geological Materials</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/RC_612_TOC_GEOLOGICAL_MATERIALS_203_821_543_d525d35b59.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Total Organic Carbon (TOC) determination in geological materials—such as metal-bearing ores, oil shales, minerals, and aggregates—is routinely performed to assess organic matter content. This is an essential quality control procedure used to identify locations of natural hydrocarbon fuel deposits and to ensure the quality and compositional integrity of raw materials used in construction.&nbsp;</p><p>The organic Carbon content of rock and shale samples is one of the most important parameters used in the evaluation of sediments as a potential source for petroleum or natural gas. TOC content controls the hydrocarbon generation potential of the rock and the content of adsorbed natural gas within the rock, as it is the source material responsible for the formation of natural hydrocarbon fossil fuel deposits.&nbsp;</p><p>The determination of TOC is also an important quality control procedure used during the manufacturing of cement, from the raw material to the final product. TOC content is used to monitor the quality of raw materials such as limestone and shale and manage the kiln operation. This allows manufacturers to ensure that the final product meets the requirements necessary for optimal performance and compliance with environmental regulations.</p><h4><strong>Instrument Model and Configuration&nbsp;</strong></h4><p>The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1845"><strong>LECO RC612</strong></a> is a multiphase Carbon and moisture determinator with a variable ramp furnace and a wide Carbon detection range that is specifically designed to differentiate various forms of Carbon by the temperature at which they combust or decompose. This capability facilitates the temperature differentiation determination of the different species of Carbon in geological materials. The following application note outlines the instrument parameters and procedure for temperature-dependent Carbon determination using the RC612.</p><h4><strong>Typical Results</strong></h4><p>The low Carbon calibration was performed utilizing a single standard, linear, force through origin calibration, using LECO 502-029 Synthetic Carbon (1.00 % C). The high Carbon calibration was performed utilizing a linear, full regression calibration, using LECO 502-030 Synthetic Carbon (4.99 % C) and LECO 501-034 Calcium Carbonate (12.01 % C). The results are reported on a dry basis.</p><h3><strong>3. Shimadzu / AOAC: Rapid analysis of harmful heavy metals in pet food using EDXRF</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/aoac_2026_24_4b781e06d8.pdf"><strong>Full PDF for download</strong></a></li></ul><p>On June 1, 2009, the Act on Ensuring the Safety of Pet Food was enacted in Japan, and compositional standards for dog and cat food were established. The ordinance specifies maximum levels for toxic heavy metals in pet food: cadmium (Cd) ≤ 1 μg/g, lead (Pb) ≤ 3 μg/g, and inorganic arsenic (As) ≤ 2 μg/g.&nbsp;</p><p>Although atomic absorption spectrophotometry (AA) and inductively coupled plasma mass spectrometry (ICP-MS) are commonly used for heavy metal analysis, they require complicated pretreatment such as acid digestion and skilled operators.&nbsp;</p><p>In this study, we focused on X-ray fluorescence analysis, which enables simple and rapid pretreatment, and analyzed five elements: Cd, Pb, As, mercury (Hg), and selenium (Se). This poster presents the usefulness of X-ray fluorescence analysis for toxic heavy metals in pet food and discusses prospects.</p><h4><strong>Methods</strong></h4><p>An energy-dispersive X-ray fluorescence spectrometer, <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=1&amp;search=altrace"><strong>ALTRACE</strong></a> (EDXRF; Shimadzu Corporation), was used for the analysis (Fig. 1). Table 1 summarizes the analytical conditions.&nbsp;</p><p>The main features of EDXRF are as follows:&nbsp;</p><ul><li>Samples can be analyzed directly or with only simple pretreatment, such as grinding.&nbsp;</li><li>Elements from sodium (11Na) to uranium (92U) can be analyzed.&nbsp;</li><li>Various sample types, including solids, powders, and liquids, can be analyzed.&nbsp;</li><li>Typical measurement times range from a few minutes to several tens of minutes.</li><li>Quantification limit is well below 1 ppm.</li></ul><h4><strong>Conclusion&nbsp;</strong></h4><p>X-ray fluorescence analysis enables the determination of harmful heavy metals with simple sample pretreatment. ALTRACE, characterized by its high sensitivity, demonstrated a lower limit of quantification sufficient for analysis at the level of a few ppm, as well as good reproducibility.</p><p>Since XRF is an elemental analysis technique, separate analysis is required to distinguish between the chemical forms of inorganic and organic arsenic; however, it is considered useful for the screening of hazardous heavy metals.</p><h3><strong>4. Thermo Fisher Scientific: Characterizing carbon materials with Raman spectroscopy</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/D19504_cc33b312f3.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Carbon nanomaterials have revolutionized the field of material science in recent years. Individual carbon nanomaterials offer a wide range of useful properties pertaining to electrical conductance, thermal resistance, and exceptional strength, making them very interesting materials to a broad range of industries. The high-level of interest in the processing, modification, and customization of these materials has created a strong demand for techniques that can be used to characterize carbon nanomaterials. Raman spectroscopy is one technique that has proven to be very well suited to many of the characterization needs with these materials.&nbsp;</p><p>Raman spectroscopy is most sensitive to highly symmetric covalent bonds with little or no natural dipole moment. The carbon-carbon bonds that make up these materials fit this criterion perfectly and as a result Raman spectroscopy is highly sensitive to these materials and able to provide a wealth of information about their structure. As we shall see, Raman spectroscopy is capable of discerning even slight changes in structure making it a very valuable tool in the characterization of carbon nanomaterials.</p><h4><strong>Raman highly sensitive to morphology&nbsp;</strong></h4><p>Raman spectroscopy is particularly well suited to molecular morphology characterization of carbon materials. Every band in the Raman spectrum corresponds directly to a specific vibrational frequency of a bond within the molecule. The vibrational frequency and hence the position of the Raman band is very sensitive to the orientation of the bands and weight of the atoms at either end of the bond. Figure 2 shows an example in which the Raman spectrum of diamond is compared to the Raman spectra of crystalline silicon and germanium. These spectra show us several things. First, note that in the case of diamond, where the material consists of highly uniform C-C bonds in a tetrahedral crystal structure, the Raman spectrum is very simple. It consists of only a single band because all of the bonds in the crystal are of the same orientation and strength resulting in a single vibrational frequency. We also see that the spectrum of diamond is easily distinguished from the spectra of silicon and germanium by the frequency (cm-1 position) of the band even though they share the same tetrahedral crystal configuration. The heavier atoms of silicon and germanium slow the vibrational frequency and shift the corresponding Raman band to lower frequency as well.&nbsp;</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2239"><strong>Thermo Scientific DXR3 Raman Microscope</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2235"><strong>Thermo Scientific DXR3 SmartRaman Spectrometer</strong></a></li></ul><h4><strong>Conclusions&nbsp;</strong></h4><p>Raman is a very powerful and valuable technique that can be of great benefit to characterization of carbon nanomaterials. Raman is particularly well suited to detect small changes in structural morphology of carbon nanomaterials making it an indispensable tool for many material scientists working with carbon nanostructures. Raman instruments are very fast and provide a great deal of flexibility in samples that can be accommodated. Every lab that is characterizing carbon nanomaterials will benefit from having access to Raman instrumentation.</p>

News from LabRulezICPMS Library - Week 41, 2026

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 12th October 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you technical note by <strong>Agilent Technologies </strong>and application notes by<strong> LECO </strong>and<strong> Shimadzu!</strong></p><h3><strong>1. Agilent Technologies: The Role of Flow Path Inertness in GC Peak Shape</strong></h3><p><strong>Evaluating the Agilent Ultra Inert Focus Open inlet liner using 105 compounds from EPA method 8270</strong></p><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/technical_overview_epa_8270_ultra_inert_focus_open_inlet_liner_5994_9487en_agilent_1f5ff6f5e7.pdf"><strong>Full PDF for download</strong></a></li></ul><section><div><div><div><div><div><div><p>Ultra Inert Focus inlet liners are designed to minimize this variability. Two internal focal points hold a bed of deactivated glass wool at a fixed position: the lower point sets wool placement, and the upper point maintains that position during use while moderating solvent-vapor expansion after injection. The result is more consistent sample introduction, reliable needle wiping, and improved injection-to-injection reproducibility, particularly for injection modes in which the sample is deposited directly onto the wool bed.<sup>4,5</sup> The large surface area of the glass wool also promotes more uniform heat transfer, improving the vaporization and column transfer of less volatile&nbsp;compounds.<sup>1,4&nbsp;</sup></p><p>Efficient sample introduction alone does not guarantee chromatographic performance. Once vaporized, analytes can encounter exposed silanol groups and other active sites within the inlet that may contribute to adsorption, catalytic degradation, and analyte loss.<sup>3,6</sup> The effect is usually most apparent for acidic, basic, polar, and otherwise reactive compounds, where these interactions can produce peak tailing, reduced recovery, and poor quantitative reproducibility.<sup>4,6</sup> Previous studies have shown that liner surface activity can affect active compound response, calibration behavior, and sensitivity<sup>6</sup> , and that improved deactivation of both the liner and the glass wool can reduce these effects.<sup>4</sup> Agilent Ultra Inert technology deactivates and minimizes residual activity within the liner, reducing the analyte interactions that can compromise recovery, peak shape, and quantitative performance.<sup>4,6</sup>&nbsp;</p><p>Active compounds interact with surfaces throughout the GC/MS flow path, so overall system inertness is an important consideration when evaluating inlet liner performance.<sup>7,8</sup> Liner performance is therefore assessed here within the broader context of flow path inertness rather than as an isolated inlet component. Both analytical columns used in this work, Agilent J&amp;W DB-5ms Ultra Inert and Agilent J&amp;W DB-5Q, come from the same development path toward inert, low-bleed GC/MS columns. The J&amp;W DB-5ms Ultra Inert is a premium phenyl arylene column, virtually equivalent to a (5%-phenyl)‑methylpolysiloxane phase, that pairs Ultra Inert surface deactivation with low-bleed chemistry.<sup>9</sup> Every column is individually inertness tested with a demanding probe mixture before release<sup>9,10</sup>, establishing a verified baseline of low surface activity that supports symmetric peak shapes, high signal-to-noise ratios, and reliable recovery for challenging semivolatile analytes such as acidic phenols, aromatic amines, and&nbsp;nitroaromatics.<sup>10,11&nbsp;</sup></p><p>The J&amp;W DB-5Q is the next generation of this premium column family, building on the DB-5ms UI design by combining Ultra Inert deactivation with ultralow‑bleed chemistry.<sup>12</sup> The DB-5Q phase retains DB-5ms-type selectivity, so existing 5ms-based methods and retention time libraries transfer directly<sup>12</sup>, while the ultralow-bleed chemistry further reduces the column bleed contribution to baseline rise and mass spectral interference during high-temperature operation.<sup>12,13</sup> The result is high signal-to-noise performance, mass spectral integrity, fast conditioning, and durability across general-use and trace‑level&nbsp;applications.</p><h4><strong>Peak shape and reproducibility&nbsp;</strong></h4><p>Two 4 mm open-bottom inlet liners, the Agilent Ultra Inert Focus Open (part&nbsp;number 5190-7107) and the Agilent Standard Deactivation Focus Open (part&nbsp;number 210-4004-5), were evaluated on two premium Agilent columns, <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=10&amp;search=DB-5ms"><strong>DB-5ms UI</strong></a> (part number 122-5532UI) and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=10&amp;search=DB-5Q"><strong>DB-5Q</strong></a> (part number 122-5532Q), for a total of four liner and column configurations. Performance was benchmarked with 105 semivolatile target compounds representative of EPA method 8270 (Table 1), chosen for their breadth of chemical classes and analyte behaviors rather than to define an intended application. Each compound was analyzed as five replicate injections of a 50 part per billion (ppb) standard solution with helium carrier gas on an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=10&amp;search=8890"><strong>Agilent 8890 GC</strong></a> coupled to an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=10&amp;search=7000E"><strong>Agilent 7000E triple quadrupole GC/MS</strong></a> fitted with a 6&nbsp;mm source extractor lens.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>Neither the liner nor the column alone determined performance in this study; injection-to-injection precision and peak symmetry tracked the inertness of the flow path.&nbsp;</p><ul><li><strong>Flow path inertness drives performance.</strong> Pairing the Agilent Ultra Inert Focus Open inlet liner with the Agilent J&amp;W DB-5Q column gave the best peak shape and precision in the study: 76.2% of peaks in the ideal symmetry window (0.9 to 1.2) and 94.3% of compounds below 5% RSD.&nbsp;</li><li><strong>Controlled wool placement improves reproducibility.</strong> Controlled wool placement in the Ultra Inert Focus Open inlet liner, combined with deactivation via Agilent Ultra Inert technology, produced the most consistent injection-to-injection performance tested, with a mean of 2.38% RSD.&nbsp;</li><li><strong>Active analytes benefit the most. </strong>Pairing the Ultra Inert deactivation of the Focus Open inlet liner with the next-generation inertness of the J&amp;W DB-5Q column delivered the largest peak symmetry gains for the most surface-sensitive compounds: weak acids (70.7%), weak bases (77.5%), phenols and halogenated phenols (72%), and aromatic amines and azo compounds (92.7%).&nbsp;</li><li><strong>Agilent J&amp;W DB-5ms Ultra Inert remains an excellent column for EPA method 8270.</strong> Every J&amp;W DB-5ms UI configuration delivered excellent precision across the full 105-compound list, consistent with its individually verified inertness testing, and it remains a best-in-class choice across many semivolatile and general-purpose application spaces.&nbsp;</li><li><strong>The Agilent J&amp;W DB-5Q column further improves performance for active compounds.</strong> As the next generation of Ultra Inert, ultralow‑bleed column chemistry, J&amp;W DB-5Q extended the symmetry and precision gains to the analytes most likely to limit method robustness, while retaining DB‑5ms-type selectivity so existing methods and retention time libraries transfer&nbsp;directly.&nbsp;</li></ul><p>Together, the Ultra Inert Focus Open inlet liner and the J&amp;W DB-5Q column give analysts a practical way to align inlet inertness with column inertness, improving reproducibility and active‑compound peak shape.</p><h3><strong>2. LECO: The Utility of Pyrolysis with Enhanced Chromatography– Time-of-Flight Mass Spectrometry for the Characterization of Nylon</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/PEGBTX_4_D_NYLON_203_821_738_35cd638c83.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Nylon is an engineered polymer that is synthesized through the reaction between dicarboxylic acid and diamine. It consists of a series of repeated amide groups that result in a polymer that has superior strength, durability, and abrasion resistance. Also featuring a low molecular weight and low cost of production, nylon is a popular choice within the world of polymers. Originally used as an alternative for silk, it quickly found many applications when WWII started in 1939, where it was used in textiles to create parachutes, ropes, and clothing for the war. Now, nylon can be found in anything from instruments like guitar strings to self-care products like toothbrushes.&nbsp;</p><p>Modern-day consumers are given a variety of options for toothbrushes. They can pick a toothbrush with medium, soft, or even extra soft bristles. Having different options for bristle types allows consumers to make choices that are closely tailored to their oral health needs. Most consumer toothbrushes use nylon for their bristles, the exception being premium or biodegradable toothbrushes that use polybutylene terephthalate (PBT) or polyethylene terephthalate (PET). In this application note, we utilized TD/Py-GCxGC-TOFMS for the characterization of nylon in typical consumer toothbrush bristles (Figure 1).</p><h4><strong>Experimental&nbsp;</strong></h4><p>Toothbrushes were purchased from local pharmacies. Sample preparation involved cutting the bristles near the base using wire cutters without removing material from the toothbrush handle. One or two bristles (approximately 5 mm in length) were placed into 60 µL quartz microtubes, which were then transferred to quartz inlet liners for analysis.&nbsp;</p><p>Pyrolysis was carried out using a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1097"><strong>Pegasus BTX 4D instrument</strong></a><strong> </strong>equipped with a GL Sciences Optic 4 inlet.¹ GC-TOFMS and ® GCxGC-TOFMS data were processed using <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/41"><strong>ChromaTOF software</strong></a><strong> </strong>with automated peak finding and spectral deconvolution for untargeted workflows, including spectral similarity searches against extensive reference libraries and mass delta (ΔM) calculations for molecular ion evaluation.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>The LECO Pegasus BTX 4D demonstrates exceptional capability for the characterization of polymeric materials, particularly when leveraging GCxGC-TOFMS. The enhanced chromatographic resolution and sensitivity provided by GCxGC generated rich, high quality pyrolysis spectral data, enabling robust and unambiguous characterization of key polymeric markers. In this study, characteristic markers associated with Nylon 6, Nylon 66, and polyethylene were confidently annotated from toothbrush bristles, underscoring the instrument’s suitability for real world industrial applications involving complex polymer matrices and consumer product analysis.</p><h3><strong>3. Shimadzu: Quantitative Analysis of Polycyclic Aromatic Hydrocarbons in Five Edible Oil Samples by GCMS-TQ8050NX</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_07_2605_en_0d1c7616d2.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Polycyclic Aromatic Hydrocarbons (PAHs) are a group of organic compounds containing two or more fused aromatic rings, formed primarily during the incomplete combustion of organic materials. PAHs are lipophilic organic contaminants that readily accumulate in lipid-rich foods such as edible oils and fats. Longterm exposure to PAHs increases the risk of cancer, harms the heart and lungs, and weakens the immune system. To protect consumer health, the European Commission (EU) 2023/915 has established maximum levels (MLs) for several PAHs[1] in edible oils and fats. Among all, benzo[a]pyrene (BaP) serves as the primary marker compound, while compliance is based on the sum of four priority PAHs (PAH4): BaP, benz[a]anthracene (BaA), benzo[b]fluoranthene (BbF), and chrysene (CHR) (Fig. 1). The maximum levels are 2 µg/kg for benzo[a]pyrene (BaP) and 10 µg/kg for the sum of the four marker PAHs (PAH4). For coconut oil and cocoa butter, the maximum level for PAH4 is 20 µg/kg.&nbsp;</p><p>The analysis of PAHs in edible oils is challenging because the high triglyceride content and other matrix components can interfere with chromatographic analysis. Therefore, efficient sample extraction and cleanup procedures are recommended for trace-level determination. In the present study, Molecularly Imprinted Polymer Solid-Phase Extraction (MIP-SPE) was employed for extraction and cleanup. A highly sensitive GCMS/MS method was developed for 14 PAHs including regulated PAHs in five commonly used edible oils namely corn oil, olive oil, sesame oil, coconut oil and rice bran oil.</p><h4><strong>Materials and methods</strong></h4><p>The quantification of PAHs was carried out using a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=1&amp;search=8050+nx"><strong>Shimadzu GCMS-TQ8050 NX</strong></a>, equipped with the HTA 2800T “all-in-one GC autosampler”. This autosampler can perform liquid injections, headspace analysis as well as Solid - Phase Microextraction (SPME).</p><h4><strong>Conclusion</strong></h4><p>A highly sensitive GC-MS/MS method was developed for the determination of 14 PAHs in five edible oils namely; olive oil, coconut oil, sesame oil, rice bran oil, and corn oil using the Shimadzu GCMS-TQ8050 NX.&nbsp;</p><p>Sample preparation was performed using AFFINIMIP® SPE PAHs Molecularly Imprinted Polymer Solid-Phase Extraction (MIP-SPE) columns, which provided effective cleanup and selective extraction of PAHs from the complex oil matrix.&nbsp;</p><p>The developed protocol is suitable for analyzing PAHs in complex, highly pigmented, and high-fat cooking oil matrices containing triglycerides, plant sterols, vitamins, and natural antioxidants.&nbsp;</p><p>Better recoveries were obtained for the heavier PAHs across the tested oil matrices, demonstrating the reliable performance of the MIP-SPE method. The results also satisfied the criteria specified in Commission Regulation (EU) 2023/915 for PAHs in edible oils.</p></div></div></div></div></div></div></section>

News from LabRulezGCMS Library - Week 42, 2026

News from LabRulezLCMS Library - Week 42, 2026

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 12th October 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring you technical note by <strong>Agilent Technologies </strong>and<strong> </strong>application notes by<strong> LECO, Metrohm </strong>and <strong>Shimadzu!</strong></p><h3><strong>1. Agilent Technologies: Agilent OpenLab ICP-MS Software Version 1.1</strong></h3><p><strong>For the Agilent 7800, 7850 &amp; 7900 ICP-MS and 8900 &amp; 9500 ICP-QQQ systems</strong></p><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/te_openlab_software_icp_ms_5994_9216en_agilent_c860090c42.pdf"><strong>Full PDF for download</strong></a><strong>&nbsp;</strong></li></ul><p>Agilent OpenLab ICP‑MS software 1.1 is the most recent version of the straightforward, user-friendly, and robust ICP‑MS workstation software. It replaces ICP‑MS MassHunter, the longstanding core software platform for Agilent ICP‑MS systems.&nbsp;</p><p>Major features in version 1.1 include a new dashboard to facilitate daily instrument operation, guided diagnostic tools to help users troubleshoot instrument issues, Method Advisor for element-focused method development, and the IntelliQuant Star Rating for easier data review, along with enhancements to IntelliQuant’s semiquantitative features.</p><p>Additionally, this version supports the new Agilent 9500 ICP‑QQQ system. When using the 9500, batches created for Agilent single quadrupole ICP‑MS instruments can be converted for the 9500 via the Batch Conversion Tool in OpenLab ICP-MS. OpenLab ICP-MS 1.1 comes with all new instruments and is compatible with Microsoft Windows 11 (64-bit). Existing Agilent ICP-MS instruments can be upgraded to version 1.1 with or without the Agilent-supplied PC bundle<sup>1</sup> .</p><h4><strong>Hardware compatibility&nbsp;</strong></h4><p>OpenLab ICP-MS 1.1 is compatible with the currently supported instrument hardware, as follows:</p><h5><strong>Variant number / instrument model</strong></h5><ul><li>#003: <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=7900"><strong>7900&nbsp;</strong></a></li><li>#004: <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=7800"><strong>7800&nbsp;</strong></a></li><li>#005: <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=8900"><strong>8900&nbsp;</strong></a></li><li>#006: <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=7850"><strong>7850&nbsp;</strong></a></li><li>#007: <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=9500"><strong>9500</strong></a></li></ul><h4><strong>Features of OpenLab ICP-MS 1.1&nbsp;</strong></h4><h5><strong>Dashboard&nbsp;</strong></h5><p>OpenLab ICP-MS 1.1 features a new dashboard that offers a quick overview of instrument status and system health. Its user-friendly layout combines essential information, including instrument configuration, maintenance status (Early Maintenance Feedback), and troubleshooting access, allowing users to quickly evaluate the system's current condition during daily use.</p><h5><strong>Instrument Hub and Diagnostics&nbsp;</strong></h5><p>The Dashboard features an Instrument Hub, shown as a dedicated pane. This hub consolidates health monitoring, maintenance, and diagnostic functions to ensure consistent instrument performance.&nbsp;</p><p>If a problem occurs, a notification appears in this pane. You can click on the notification to see detailed information or start Diagnostics, a new guided troubleshooting tool. Diagnostics helps identify potential causes of any problems using software, offering step-by-step guidance with images and videos. This design allows users to troubleshoot issues easily, even without prior specialist experience.</p><h4><strong>Method Advisor and import for </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=9500"><strong>9500 ICP-QQQ</strong></a><strong>&nbsp;</strong></h4><p>Method Advisor is an element-centric method creation tool designed specifically for the 9500 ICP-QQQ. By choosing the elements to measure, users get automatic application of recommended method conditions, drawing from Agilent’s over ten years of experience in triple quadrupole ICP-MS. This simplifies the process of developing methods for ICP-QQQ analysis. To create a batch with Method Advisor, simply select the target elements, input calibration data, and prepare a sample list. The tool then automatically sets key parameters—such as cell gas modes and acquisition masses—optimizing the 9500’s performance. This makes reliable method development accessible even for analysts who are new to ICP-QQQ or the OpenLab ICP-MS software.&nbsp;</p><p>Methods from Agilent single quadrupole ICP-MS instruments can be imported using the method import tool. This tool converts the ICP-MS method into a format compatible with the 9500 ICP-QQQ. Users simply select the base batch file and choose whether to import the method directly or optimize it for the 9500. The tool then determines the optimal conditions and fine-tunes the instrument settings accordingly.&nbsp;</p><p>Target element selection can also be performed using a CSV file. This allows methods from non‑Agilent instruments to be transitioned efficiently by importing a list of target elements into Method Advisor.</p><h4><strong>Software compatibility&nbsp;</strong></h4><p>Version 1.1 of the OpenLab ICP-MS software is compatible with:&nbsp;</p><ul><li>Agilent 7800, 7850, and 7900 ICP-MS and 8900 and 9500 ICP-QQQ and their associated peripherals&nbsp;</li><li>Third-party autosamplers and accessories, using plug-ins developed by the supplier&nbsp;</li><li><strong>Agilent 7890 &amp; 8890 GC and 7693 autosampler </strong>when the optional chromatographic software module is installed&nbsp;</li><li>Most <strong>Agilent 1100 and 1200 Series HPLC modules</strong> and peripherals when the optional chromatographic module is installed</li></ul><h3><strong>2. LECO: Titanium Alloy Analysis by Glow Discharge Spectroscopy</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/GDS_900_TITANIUM_ALLOYS_203_821_737_cdf595a170.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Titanium alloys play a critical role in today's high-tech world, offering an exceptional combination of strength-toweight ratio, corrosion resistance, high-temperature strength retention, and biocompatibility. To achieve these properties, titanium is commonly alloyed with elements such as aluminum, tin, vanadium, zirconium, molybdenum, niobium, and iron. Because alloy composition directly affects material performance and compliance with product specifications, accurate elemental analysis is essential for quality assurance. As researchers continue to investigate new titanium alloy formulations, analytical techniques such as glow discharge spectroscopy (GDS) provide a fast and effective means of determining elemental composition.&nbsp;</p><p>Titanium alloys are used extensively across a wide range of industries. Aerospace and defense applications account for the largest share of titanium consumption, while medical and biomedical fields utilize titanium for artificial joints, implants, and surgical instruments. The chemical processing industry relies on titanium alloys for heat exchangers and desalination equipment due to their outstanding corrosion resistance. Titanium also finds application in premium consumer products, including bicycles, golf clubs, and luxury watches.&nbsp;</p><p><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1842"><strong>LECO's GDS900</strong></a> is an <strong>atomic emission spectrometer</strong> designed for the elemental analysis of solid conductive materials. The instrument determines elemental composition by measuring the characteristic light emitted from a sample when its atoms are excited. At the heart of the system is a glow discharge source that uniformly sputters material from the sample surface, offering advantages over many other excitation techniques. Because excitation occurs within the glow discharge plasma and is spatially separated from the sample surface, the influence of the sample's metallurgical and chemical history is significantly reduced.Glow discharge spectra are dominated by neutral atomic emission lines, resulting in relatively simple spectra with minimal spectral interferences. Although singly ionized transitions are also observed, glow discharge spectra remain considerably less complex than those produced by many other atomic emission techniques. In addition, the response of a typical glow discharge analytical line is highly linear across a broad concentration range, reducing the number of wavelengths required for accurate quantitative analysis.&nbsp;</p><p>The GDS900 delivers state-of-the-art technology specifically engineered for routine elemental determination in both ferrous and nonferrous materials. LECO's exclusive CCDbased optical design provides the measurement stability, flexibility, and analytical performance required for demanding production and quality-control environments.</p><h3><strong>3. Metrohm: Automated quality control of gasoline using NIR spectroscopy</strong></h3><p><strong>Rapid determination of AKI, RON, MON, density, oxygenates, benzene, olefins, and aromatic content in gasoline</strong></p><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/GDS_900_TITANIUM_ALLOYS_203_821_737_cdf595a170.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Determining the key quality parameters of gasoline, namely research octane number (RON), motor octane number (MON), anti-knock index (AKI), oxygenates, benzene, olefins, and aromatic content, conventionally requires several laborious analytical methods which need trained personnel. This Application Note demonstrates that the OMNIS NIR Analyzer Liquid, operating in the near-infrared (NIR) spectral region, provides a cost-efficient, fast solution for the multiparameter analysis of gasoline. Its precise temperature control ensures that all samples are measured in compliance with ASTM D8340, ASTM D8321, and ASTM D6122. The system offers fully automated operation when combined with the OMNIS Sample Robot M – NIR.</p><h4><strong>EXPERIMENTAL EQUIPMENT&nbsp;</strong></h4><p>Gasoline fuel samples were measured with an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=220&amp;search=OMNIS+NIR"><strong>OMNIS NIR Analyzer Liquid</strong></a> (Figure 1) in transmission mode (1000–2250 nm) at 30 °C. The OMNIS Sample Robot M – NIR was used for fully automated sample measurement with disposable vials (8 mm pathlength). The vials are closed, reducing the flammability risk for fuel samples to an absolute minimum. All data acquisition and prediction model development was performed with <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=220&amp;search=OMNIS+software"><strong>OMNIS Software</strong></a>.</p><h4><strong>CONCLUSION</strong></h4><p>This Application Note shows the feasibility of using NIR spectroscopy for gasoline quality testing. Compared to wet chemical methods, the time to result is a major advantage of NIRS. Each measurement is performed in a few seconds, and all parameters are measured simultaneously. The possibility of fully automated analysis in combination with the OMNIS Sample Robot M – NIR increases throughput, maximizing gasoline quality control efficiency. With the OMNIS gasoline pre-calibration (6.06008.008), users can measure all the mentioned parameters from day one.</p><h3><strong>4. Shimadzu: Extractable and Leachable Study of Pharmaceutical Packaging Material used to Store Penicillin-V Using </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=1&amp;search=2050"><strong>ICPMS-2050</strong></a></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_06_sip_sp_079_en_5775bf5d71.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User benefits</strong></h5><ul><li>Simultaneous qualitative scanning feature benefits to user in identification of non-targeted elements, supporting the creation of a comprehensive extractable profile.&nbsp;</li><li>Proprietary Mini-Torch technology enables stable plasma with highersensitivity and lower gas consumption (11 L/min).&nbsp;</li><li>LabSolutions ICPMS ensures compliance with regulatory norms in spectroscopy products,streamlining data management.</li></ul><p>Extractable and leachable (E &amp; L) studies are becoming increasingly important in the pharmaceutical industry as it is a mandatory requirement from the FDA during filing of the drug product. The purpose of E &amp; L studies is to identify and evaluate possible toxicological risks. In this, the regulatory references aim to identify traces of potential chemical substances. These substances may be harmful to patients due to their toxicity or may impact the activity of the drug product. Hence, to ensure the safety and efficacy of the drug throughout its shelf-life, E &amp; L studies play an important role.</p><h4><strong>What are Extractables and Leachables?&nbsp;</strong></h4><ul><li><strong>Extractables</strong> are organic and inorganic chemical entities that are released from a pharmaceutical packaging/delivery system, packaging component, or packaging material of construction into an extraction solvent under laboratory conditions[1] .&nbsp;</li><li><strong>Leachables</strong> are foreign organic and inorganic chemical entities that are present in a packaged drug product because they have leached into the packaged drug product from a packaging/delivery system, packaging component, or packaging material of construction under normal conditions of storage and use or during accelerated drug product stability studies[1].&nbsp;</li></ul><h4><strong>Analytical Conditions</strong></h4><ul><li><strong>Instrument: </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=1&amp;search=2050"><strong>ICPMS-2050</strong></a><strong> </strong>with AS-20s</li></ul><h4><strong>Conclusion&nbsp;</strong></h4><ul><li>A Shimadzu ICPMS-2050 spectrometer was utilized to evaluate elemental impurities leached from a Container Closure Pack (CCP) under various acidified extraction environments. To simulate accelerated leaching, extraction was performed at elevated temperatures. Initial qualitative screening revealed the presence of several key analytes specifically aluminum, boron, calcium, iron, potassium, magnesium, sodium, and silicon which showed a significant response relative to the diluent.&nbsp;</li><li>This study shows that the ICPMS-2050 is sensitive enough to identify and quantify extractables at the permissible limits set by ICH Q3D targeted as well as non targeted elements by using Scan mode feature.&nbsp;</li><li>Shimadzu ICPMS Series adopted total 11 L/min argon gas consumption by implementing Mini torch accessory attachment is help to minimize the operation cost without compromising the sensitivity and plasma stability.&nbsp;</li><li><strong>LabSolutions software: </strong>Shimadzu ICPMS ensures compliance with regulatory norms in spectroscopy products,streamlining data management and analysis.</li></ul>

News from LabRulezICPMS Library - Week 42, 2026

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Thermo Fisher Scientific Mass Spectrometry Users’ Meetings 2026

LECO Training Course GDS900/950 & CDP

Thermo Fisher Scientific Analytical solutions forum

Validated Method for PFAS Testing in Food, Including Meats

Confidence in PFAS Data: Smarter Sample Prep, Contamination Control, Highly Sensitive and Robust MS

From sample to result: advanced sample prep strategies for food and environmental matrices