<p><strong>Taťána Gazárková is currently a&nbsp;postdoctoral fellow in the Laboratory of Antibiotic Resistance and Microbial Metabolomics. During her doctoral studies, she focused on chromatography and mass spectrometry. Recently, she was awarded second place in the “Sanofi Prize for Pharmacy 2026” competition.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MBU_AV_CR_Lukas_Biba_Rozhovor_Cim_zaujala_analyticka_chemie_postdoktorandku_Tatanu_Gazarkovou_7450c646fa.jpg" alt="MBÚ/Lukas Biba:&nbsp;Sanofi Prize for Pharmacy 2026" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MBU_AV_CR_Lukas_Biba_Rozhovor_Cim_zaujala_analyticka_chemie_postdoktorandku_Tatanu_Gazarkovou_7450c646fa.jpg 234w," sizes="100vw" width="1024" height="683"></p><p><strong>Taťána Gazárková </strong>is currently a&nbsp;postdoctoral fellow in the <strong>Laboratory of Antibiotic Resistance and Microbial Metabolomics</strong>. During her doctoral studies, she focused on chromatography and mass spectrometry. Recently, she was awarded second place in the <strong>“Sanofi Prize for Pharmacy 2026” </strong>competition, which is awarded by the<strong> French Embassy in the Czech Republic</strong> for her dissertation – Steroid Analysis Using Modern Chromatographic and Mass Spectrometry Techniques: From Fundamental Studies to Targeted Bioanalytical Applications (supervisor: <strong>Lucie Nováková, Charles University</strong>).&nbsp;</p><h5><strong>What makes this field particularly exciting or unique in your view?</strong></h5><p>What I&nbsp;enjoy about analytical chemistry is that, to a&nbsp;certain extent, it is a&nbsp;kind of detective work. You are often looking for ways to “make the invisible visible”. In other words, extract the information you are interested in from a&nbsp;complex sample and then interpret it correctly. What also appeals to me about bioanalytical chemistry is its interdisciplinary nature. It brings together analytical chemistry, biochemistry, biology and medicine, which means that you need to be able not only to translate a&nbsp;biological or clinical question into a&nbsp;measurable analytical experiment, but also to place the resulting data back into a&nbsp;broader biological context. This combination of different perspectives is probably what I&nbsp;enjoy most about the field. At the same time, there is still plenty of room for fundamental research, ranging from studying analytical techniques themselves and improving them to developing new methodological approaches.</p><h5><strong>How did you end up at the </strong><a target="_blank" rel="noopener noreferrer" href="https://mbu.cas.cz/en/research/laboratory-of-antibiotic-resistance-and-microbial-metabolomics"><strong>Laboratory of Antibiotic Resistance and Microbial Metabolomics</strong></a><strong>, and what project are you currently working on?</strong></h5><p>I came to the Institute of Microbiology through a&nbsp;joint project between<strong> Dr Zdeněk Kameník and Assoc. Prof. Jan Bobek from the First Faculty of Medicine, Charles University</strong>. For me, it was also an opportunity to move from targeted analysis and the study of chromatographic techniques towards untargeted metabolomics and new biological questions.</p><p>In the project, we are trying to identify new biologically active compounds that would be effective, particularly against pathogenic fungi. As a&nbsp;potential source of such compounds, we study streptomycetes, bacteria known for their ability to produce a&nbsp;wide range of biologically active compounds, including many antibiotics that are currently in clinical use. We focus on less-explored host-associated streptomycetes, in which we had already observed antifungal activity in previous experiments. We are especially interested in strains active against Candida albicans whose activity cannot be explained by the presence of a&nbsp;known bioactive compound. These strains may represent an interesting source of novel compounds. We then integrate the results of untargeted metabolomic analyses with genomic analyses, which allows us to obtain a&nbsp;more comprehensive view of the biosynthetic potential of selected strains.</p><h5><strong>You also took part in this year’s Vědafest, a&nbsp;science outreach event for the public. What was it like?</strong></h5><p>I already had some experience with science outreach through events such as Researchers’ Night and the Science Fair at my previous institution, but this year’s Vědafest was still new to me in some ways. This time, I&nbsp;was presenting a&nbsp;field that I&nbsp;myself had entered only relatively recently. It was therefore more challenging to find the right analogies and explain the essence of the topic in a&nbsp;way that was simple, yet precise and scientifically accurate. At the same time, that was exactly what made it inspiring. It forces you to look at your own work from a&nbsp;different perspective. What I&nbsp;enjoyed most was the spontaneity and curiosity of the children, who often came up with questions that would never even occur to an adult.</p><h5><strong>What are the biggest challenges you face on your scientific journey, and what helps you overcome them?</strong></h5><p>One of the greatest, but at the same time most interesting, challenges is, in my view, the uncertainty that is inseparably linked to research. For a&nbsp;long time, you often do not know whether you have taken the right direction in addressing a&nbsp;particular question or whether you will ultimately manage to find that figurative final piece of the puzzle. At the same time, this uncertainty is precisely what makes science exciting for me.</p><p>Another major challenge, particularly in interdisciplinary projects, is communication. It is important from the very formulation of a&nbsp;hypothesis and the planning of experiments through to the interpretation of results, including negative ones, and placing them in a&nbsp;broader context. To some extent, every field has its own language, and finding a&nbsp;common understanding is not always straightforward. Personally, I&nbsp;find it very helpful to be able to discuss problems with colleagues on an ongoing basis, whether individually or during regular laboratory seminars. One of the major strengths of our current group is its interdisciplinary nature, which allows me to look at the same problem from several different perspectives. It is also important for me not to lose my curiosity, because that is ultimately what leads us to ask further questions.</p><h5><strong>What are your plans after completing your PhD?</strong></h5><p>After finishing my PhD, I&nbsp;decided that I&nbsp;do not need to have everything that comes next precisely mapped out straight away. I&nbsp;would like to keep different options open for a&nbsp;while and continue building on my experience in analytical chemistry, while at the same time connecting it with other areas that have a&nbsp;biological or medical relevance. I&nbsp;believe that we can keep learning throughout our lives, so I&nbsp;am quite curious to see where the next stage of my journey will take me.</p><p><i>Thank you for the interview!</i></p>

Interview: What Drew Postdoc Taťána Gazárková to Analytical Chemistry

<p><strong>Per- and polyfluoroalkyl substances (PFAS) have earned the moniker "forever chemicals" due to their extreme persistence in the environment. Their detection is crucial for protecting public health and the environment as these synthetic compounds continue to pose significant challenges worldwide. This comprehensive exploration examines why PFAS detection matters, current detection methods, and future directions in addressing PFAS contamination.</strong></p><h3><strong>Understanding PFAS and Their Health Impacts</strong></h3><p>PFAS are a class of synthetic organic compounds with diverse structures, properties, and uses. Despite their diversity, all PFAS contain perfluoroalkyl moieties that are extremely resistant to environmental and metabolic degradation [1]. This high persistence is a defining characteristic that makes PFAS management particularly challenging.</p><h3><strong>Documented Health Effects</strong></h3><p>Current scientific research has linked PFAS exposure to numerous adverse health outcomes:</p><ul><li>Reproductive effects including decreased fertility and increased high blood pressure in pregnant women [8]</li><li>Developmental effects in children such as low birth weight, accelerated puberty, and behavioral changes [8]</li><li>Reduced immune system function, including decreased vaccine response</li><li>Interference with natural hormones and endocrine disruption</li><li>Increased cholesterol levels and obesity risk</li><li>Increased risk of several cancers, including prostate, kidney, testicular, oral cavity/pharynx, brain, and endocrine cancers [3]</li></ul><p>A 2023 study linked PFAS-contaminated water with up to a <strong>33% increase in cancer incidence</strong> in affected areas [3]. The study compared regions with elevated PFAS levels to cancer data from the National Cancer Institute, finding higher incidences of various cancers after controlling for factors like smoking and obesity.</p><h3><strong>Environmental Persistence and Contamination</strong></h3><p>The extreme persistence of PFAS represents a fundamental concern for environmental management. PFAS are considered the most environmentally persistent substances among organic chemicals [7]. This persistence means that even if all PFAS uses were immediately phased out, existing contamination would continue to affect ecosystems and water supplies for generations.</p><p>A 2023 study at a military fire training site estimated that PFAS contamination will persist for centuries without remediation [7]. The research found that terminal PFAS still exceed regulatory limits by 2000-fold decades after aqueous film-forming foam (AFFF) use ceased, with precursors accounting for around half of the extractable organofluorine across years.</p><h3><strong>Current Detection Methods</strong></h3><h4><strong>EPA Standardized Methods</strong></h4><p>The<strong> Environmental Protection Agency (EPA</strong>) has developed several standardized methods for PFAS detection, each with specific applications and capabilities:</p><h5><strong>EPA Method 533</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/epa-533-drying-down-pfas-samples-after-spe"><strong>EPA Method 533</strong></a> focuses on "short chain" PFAS with carbon chain lengths of<strong> C4 to C12</strong>. Released in December 2019, this method complements Method 537.1 and includes several key features:</p><ul><li>Uses isotope dilution quantification approach with extracted internal standards, which reduces overall analytical uncertainty</li><li>Employs weak anion exchange solid phase extraction cartridges as opposed to polystyrene divinylbenzene used in 537.1</li><li>Can analyze 25 PFAS compounds, including additional short-chain PFAS that were not apart of Method 537.1</li><li>Allows for longer holding times: 28 days to extraction and 28 days to analyze (compared to 14 days to extraction in Method 537.1)</li><li>Uses ammonium acetate as a preservative (versus Trisma in Method 537.1) [1]</li></ul><h5><strong>EPA Method 537/537.1</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/sample-concentration-epa-method-537-pfas-determination"><strong>EPA Method 537 </strong></a>was first published in 2009 for the determination of 14 PFAS in drinking water [6]. It was later updated to Method 537.1 in 2018 (with editorial updates in 2020) to expand its capabilities:</p><ul><li>Uses<a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/what-is-solid-phase-extraction-spe"><strong> solid phase extraction (SPE) </strong></a>and<a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/preparing-samples-for-lc-ms/ms-analysis"><strong> liquid chromatography/tandem mass spectrometry (LC-MS/MS)</strong></a></li><li>Method 537.1 expanded detection to 18 PFAS compounds, including HFPO-DA (one component of GenX technology)</li><li>Utilizes styrene-divinylbenzene (SDVB) media for extraction</li><li>Requires samples to be extracted within 14 days and analyzed within 28 days</li><li>Methanol is used to elute the extracts. This should then be reconstituted with a 96:4 methanol:water mixture [1]</li></ul><p>Together, Methods 533 and 537.1 can detect a total of <strong>29 unique PFAS compounds in drinking water </strong>and are approved for monitoring under the fifth Unregulated Contaminant Monitoring Rule (UCMR 5) and the PFAS National Primary Drinking Water Regulation [1] [3].</p><h5><strong>EPA Method 1633</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/preparing-diverse-sample-matrices-for-epa-method-1633"><strong>EPA Method 1633</strong></a>, released in 2024, represents a significant advancement in PFAS analysis:</p><ul><li>Developed for the analysis of <strong>40 PFAS compounds </strong>in various matrices, including surface water, groundwater, wastewater, soil, biosolids, sediment, landfill leachate, and fish tissue</li><li>Expands beyond the drinking water focus of Methods 533 and 537.1</li><li>Provides a standardized approach that may replace modified drinking water methods (i.e., modified EPA 537) that were previously used for non-drinking water matrices [1]</li></ul><h4><strong>Conventional Analytical Techniques</strong></h4><p>The gold standard for PFAS analysis involves chromatographic techniques coupled with mass spectrometry:</p><ul><li>Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) is the most widely used method for PFAS analysis, offering high sensitivity and specificity [1]</li><li>High-Resolution Mass Spectrometry (HRMS) allows for rapid detection and identification of PFAS species at very low concentrations [5]</li></ul><p>These techniques can detect PFAS at parts per trillion (ppt) levels, which is essential given the low concentrations at which PFAS can cause health effects [1]. However, these methods require sophisticated equipment, specialized training, and significant financial resources, making them inaccessible in many regions, particularly in developing countries.</p><h4><strong>Emerging Detection Technologies</strong></h4><p>Several innovative approaches are being developed to address the limitations of conventional methods:</p><ul><li>Electrochemical biosensors using modified electrodes have shown promise for selective PFAS detection with low detection limits [2]</li><li>Surface-Enhanced Raman Spectroscopy (SERS) uses metallic nanoparticles and can be made into a portable method for on-site testing [1]</li><li>Molecular imprinted polymers (MIPs) offer thermal and physical stability, reusability, and low-cost synthesis for PFAS detection [6]</li></ul><p>These emerging technologies aim to provide more accessible, field-deployable, and cost-effective alternatives to traditional laboratory-based methods.</p><h3><strong>Challenges in PFAS Detection</strong></h3><h4><strong>Analytical Challenges</strong></h4><p>Detecting PFAS presents several technical challenges:</p><ul><li>The ubiquity of PFAS in laboratory equipment and accessories can lead to background contamination when measuring at parts-per-trillion levels [1]</li><li>Many components in liquid chromatographs, mass spectrometers, and solid-phase extraction systems contain materials that can leach PFAS compounds [9]</li><li>The vast number of PFAS (thousands of compounds) makes comprehensive detection difficult, as analytical standards are only available for a small subset [1]</li><li>Complex matrices like food and environmental samples require sophisticated sample preparation techniques</li></ul><h4><strong>Global Disparities in Detection Capabilities</strong></h4><p>Access to PFAS detection technology varies significantly worldwide:</p><ul><li>Many developing regions, particularly in Africa, lack adequately equipped laboratories with the necessary instrumentation to detect and measure PFAS</li><li>There is often a scarcity of qualified professionals with experience in PFAS analysis in these regions</li><li>The high cost of acquiring and maintaining sophisticated analytical instruments presents a substantial obstacle to conducting extensive PFAS investigations in resource-limited settings [1]</li><li>Competing priorities such as infectious diseases, poverty, and food security often divert attention and resources from environmental pollutants like PFAS</li></ul><h4><strong>Regulatory Landscape and Compliance</strong></h4><p>The regulatory framework for PFAS is evolving rapidly worldwide:</p><ul><li>The EPA finalized Section 8(a)(7) of the Toxic Substances Control Act in September 2024, requiring manufacturers and importers to report on their use of PFAS since 2011 [10]</li><li>Electronic reporting for PFAS will open on July 11, 2025, with final reporting deadlines in 2026</li><li>Companies must report detailed information including chemical identity, production volumes, industrial and consumer products, worker exposure, and disposal methods [10]</li></ul><p>These regulations are driving demand for more effective and accessible PFAS detection methods to ensure compliance and protect public health.</p><h3><strong>Future Directions in PFAS Detection</strong></h3><h4><strong>Technological Advancements</strong></h4><p>The future of PFAS detection lies in developing more accessible, sensitive, and comprehensive methods:</p><ul><li>Non-targeted screening methods that can identify unknown PFAS compounds without requiring analytical standards for each specific compound</li><li>Total fluorine analysis techniques like Adsorbable Organic Fluorine and Total Oxidizable Precursor Assay that can quantify the presence of fluorine atoms within a sample [1]</li><li>Portable sensors and field-deployable technologies that enable on-site monitoring and rapid response to contamination events</li><li>AI-driven solutions that can improve data analysis and interpretation for complex PFAS mixtures</li></ul><h4><strong>Collaborative Approaches</strong></h4><p>Addressing the global challenge of PFAS detection requires coordinated efforts:</p><ul><li>International partnerships between researchers in developed and developing regions to enhance expertise and capacity building</li><li>Standardization of analytical methods to ensure consistency and comparability of results across different laboratories and regions</li><li>Open data sharing and collaboration across countries to leverage collective knowledge and resources</li><li>Integration of PFAS monitoring into broader environmental and public health surveillance systems</li></ul><h3><strong>Conclusion</strong></h3><p>The detection of PFAS is not merely a technical challenge but a critical public health and environmental imperative [1]. As these "forever chemicals" continue to persist in our environment, developing effective, accessible, and comprehensive detection methods becomes increasingly important. By advancing detection technologies, strengthening regulatory frameworks, and fostering global collaboration, we can better understand, monitor, and ultimately mitigate the impacts of PFAS contamination.</p><p>The EPA's standardized methods (533, 537.1, and 1633) provide crucial tools for monitoring PFAS in various environmental matrices, but continued innovation is needed to address the full spectrum of PFAS compounds and to make detection more accessible globally [1] [6]. The path forward requires sustained investment in research and development, capacity building in resource-limited settings, and a commitment to environmental justice that ensures all communities have access to the tools and information needed to protect themselves from PFAS exposure. Only through such comprehensive approaches can we hope to address the complex challenges posed by these persistent pollutants.</p><p><span>Be sure to check out our other installments of our&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/introducing-our-environmental-contaminants-series-making-sense-of-the-alphabet-soup"><span>Environmental Contaminant Series</span></a><span>&nbsp;covering&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-persistent-organic-pollutants-pops"><span>Persistent Organic Pollutants (POPs)</span></a><span>,&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-polycyclic-aromatic-hydrocarbons-pahs"><span>Polycyclic Aromatic Hydrocarbons (PAHs)</span></a><span>,&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-semi-volatile-organic-compounds-svocs"><span>Semi-Volatile Organic Compounds (SVOCs)</span></a><span>, and </span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-polychlorinated-biphenyls-pcbs"><span>Polychlorinated Biphenyls (PCBs)</span></a><span>.</span></p>

The Importance of Detecting Per- and Polyfluoroalkyl Substances (PFAS)

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 31st August 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring you brochures by <strong>Agilent Technologies </strong>and<strong> Waters Corporation </strong>and application notes by <strong>Shimadzu </strong>and<strong> Thermo Fisher Scientific!</strong></p><h3><strong>1. Agilent Technologies: Agilent OpenLab ICP-MS Software</strong></h3><p><strong>Simplify every step of ICP-MS analysis</strong></p><p><strong>For Agilent </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=7800"><strong>7800</strong></a><strong>, </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=7850"><strong>7850</strong></a><strong>, and </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=7900"><strong>7900</strong></a><strong> ICP-MS systems, and Agilent </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=8900"><strong>8900</strong></a><strong> and </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=9500"><strong>9500 ICP-QQQ</strong></a><strong> systems.</strong></p><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/br_openlab_icp_ms_software_5994_9288en_agilent_05f01dcdef.pdf"><strong>Full PDF for download</strong></a><strong>&nbsp;</strong></li></ul><p>The brochure introduces <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=OpenLab+ICP-MS+Software"><strong>Agilent OpenLab ICP-MS Software</strong></a>, designed to simplify routine operation and data handling for <strong>Agilent 7800, 7850, and 7900 ICP-MS systems</strong> and the <strong>8900</strong> and <strong>9500</strong> <strong>ICP-QQQ systems</strong>. The software supports the complete analytical workflow—from checking instrument readiness and creating batches to acquisition, data review, reporting, and compliance. A central dashboard provides an overview of system status, maintenance requirements, instrument health, and utilization, while Smart EMF and post-run performance checks help users identify when maintenance may be required. Guided Diagnostics, Meter Monitor, and time-stamped system records also support troubleshooting by tracking parameters such as vacuum levels, gas flows, and temperatures.</p><p>Method and batch setup are designed to reduce manual configuration. Batches can be created from preset methods, templates, existing batches, Method Wizard, or Method Advisor, and legacy Agilent ICP-MS MassHunter batches can be opened directly in OpenLab ICP-MS. For the <strong>9500 ICP-QQQ</strong>, Method Advisor provides an element-focused approach in which users select target elements and calibration information while the software applies recommended acquisition masses and cell-gas conditions. Preset methods are available for applications including <strong>EPA 200.8/EPA 6020, USP &lt;232&gt;, ICH Q3D, and Chinese Pharmacopoeia requirements</strong>, while an IntelliQuant Screening preset supports semiquantitative screening of unknown samples. Routine instrument tasks can also be automated through autotuning, startup checks, batch queues, end-of-run verification, rinse functions, and automatic shutdown.</p><p>For data evaluation, OpenLab ICP-MS provides a real-time workspace where users can review analyte concentrations, internal-standard recoveries, stability plots, spectra or chromatograms, calibration information, QC charts, and IntelliQuant results in a single view. <strong>IntelliQuant</strong> acquires a complete mass spectrum and displays semiquantitative elemental concentrations using a color-coded periodic table, while <strong>IntelliQuant Star Rating</strong> assigns a zero-to-five-star data-quality score based on factors such as potential interferences, calibration quality, background, detection limits, and precision. Reporting options include whole-batch reports, elemental impurity reports for USP &lt;232&gt;/&lt;233&gt; and ICH Q3D, customizable reports, structured CSV export, and direct data transfer to LIMS.</p><p>The software can be expanded for specialized applications, including <strong>LC-ICP-MS and GC-ICP-MS</strong>, advanced QC workflows, single-particle ICP-MS and FFF-ICP-MS, ADS 2 automation, semiconductor analysis, and peripheral-device control. Supported analytical approaches include external calibration, standard additions, semiquantitative calibration, isotope ratios, and isotope dilution. For regulated laboratories, OpenLab ICP-MS can be combined with scalable OpenLab compliance solutions providing electronic signatures, user access control, configurable roles, system activity logs, and audit trails, supporting workflows subject to <strong>21 CFR Part 11, EU Annex 11, and equivalent regulations</strong>. Overall, the platform is positioned as a unified environment for routine and advanced ICP-MS workflows, combining instrument control, method setup, diagnostics, data-quality assessment, reporting, and compliance support.</p><h3><strong>2. Shimadzu: Identification of Virgin PET and Recycled PET by X-ray Fluorescence Spectrometry</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_01_01204_en_f3f20ff020.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User benefits</strong></h5><ul><li>EDX enables the identification of recycled PET.&nbsp;</li><li>Measurements are quick and simple, require no cumbersome pretreatment, and can be automated using a multi-sample turret.&nbsp;</li><li>The instrument offers excellent cost-performance and supports the detection of a wide range of elements.</li></ul><p>Establishing a sustainable circular economy is a major societal challenge, and recycling plastic materials such as PET (polyethylene terephthalate) plays a particularly important role in reducing environmental impact. Large numbers of PET bottles and molded products are used every day in the food and beverage sectors. To recycle these materials safely and reliably, technologies are required that can accurately identify their origin. In practice, however, appearance and conventional physical properties alone are insufficient to distinguish virgin material from recycled material, creating a need for a more reliable identification method.&nbsp;</p><p>For rapid identification in industrial settings, a method requiring little or no pretreatment is highly desirable. In some cases, nondestructive analysis is also needed to enable subsequent application of other analytical techniques. This article presents a practical approach in which metal catalysts present in PET are detected by EDX (Energy-Dispersive X-ray Spectroscopy) and used to distinguish material-recycled PET from virgin PET.</p><h4><strong>Principle and Overview&nbsp;</strong></h4><p>Metal catalysts such as antimony (Sb) and germanium (Ge) are used in the synthesis of PET resin. These catalyst metals have been reported to be useful indicators of material origin. 1),2) For example, Sb and Ge are frequently detected together in material-recycled PET, whereas only one catalyst metal is detected in chemically recycled PET and virgin PET. This likely reflects the fact that material-recycled PET is derived from a mixture of feedstocks using different catalysts.&nbsp;</p><p>ICP-AES (ICP optical emission spectrometry) and ICP-MS (ICP mass spectrometry), which are commonly applied to catalyst metal analysis, provide high sensitivity and accuracy. However, they require pretreatment to convert the sample into a solution, thereby lengthening the analytical workflow. By contrast, EDX can measure solid samples directly, making it well-suited to applications requiring rapid results, such as incoming material inspection and in-line analysis in molding plants. Because EDX is non-destructive, it is also suitable for multimodal analytical workflows.&nbsp;</p><p>On the other hand, some commercially available handheld EDX instruments do not support elements such as Sb and Ge. At the same time, higher-end systems may not offer the specifications or price range needed for industrial deployment. The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=1&amp;search=EDX-7200"><strong>EDX-7200</strong></a> supports a broad range of elements with excellent cost performance. This article describes the analysis of Sb and Ge in PET using this instrument.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>EDX enables rapid and straightforward elemental analysis without cumbersome sample pretreatment. Previous studies have shown that the presence of Sb and Ge can be used to identify recycled PET. Building on this concept, this article presents a practical analytical approach based on EDX. Using the EDX-7200, which combines broad elemental coverage with excellent cost performance, the proposed method provides a practical tool for rapid on-site identification, quality control, and traceability management. When combined with physical property data and other information, this approach is expected to contribute to the safety assessment and quality assurance of recycled materials, thereby supporting a more advanced circular economy.</p><h3><strong>3. Thermo Fisher Scientific: Optimizing lithium-ion battery recycling operations using handheld XRF analysis</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/lithium_ion_battery_recycling_handheld_xrf_analysis_an1120_en_4c00477b78.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The shift to a low-carbon economy and the adoption of electric vehicles will drive an exponential increase in the demand for lithium-ion batteries. As a corollary to this, the International Energy Agency expects the demand for some key commodities to increase significantly over the next two decades: the demand for Copper (Cu) is anticipated to increase by more than 40%; for nickel (Ni) and cobalt (Co), by 60-70% each; and for lithium (Li), by nearly 90%.¹ This will translate into increased mining activities and potentially generate larger amounts of deleterious waste.&nbsp;</p><p>To reduce the environmental impact and limit reliance on scarce commodities associated with economical and geopolitical implications, several countries have implemented regulations regarding producers’ responsibilities.² These regulations contain both incentives and accountability guidelines for lithium-ion battery and electric vehicles manufacturers. Their goal is to facilitate the emergence of a circular economy in which recycling will increasingly contribute to the supply of the strategic raw materials.&nbsp;</p><p>Lithium-ion batteries are made of multiple components, the most valuable being the cathode that contains between 40 and 70% ³, ⁴ of the total value of the battery, depending on its exact chemistry. As of 2023, lithium nickel cobalt manganese oxides (NCM) account for 66% of lithium-ion battery cathode active materials for electric vehicles, followed by lithium iron phosphates (LFP) which account for 24%, and lithium nickel cobalt aluminum oxide (NCA) accounts for the remaining 10%.³</p><h4><strong>Handheld X-ray Fluorescence Analysis&nbsp;</strong></h4><p>Handheld X-ray fluorescence analysis (HHXRF) is an elemental analysis technique that has proven to be cost-effective in recycling areas such as scrap metal and automotive catalytic converters. HHXRF can measure elements from magnesium (Mg) to uranium (U) in various types of materials such as metals and alloys; non-metallic inorganic materials such as ceramics; or ores or plastics. The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1993"><strong>Thermo Scientific™ Niton™ XL2</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1992"><strong>Thermo Scientific™ Niton™ XL5 Plus Handheld XRF Analyzers </strong></a>deliver accurate elemental analysis in real time, with little or no sample preparation, across multiple steps of the lithium-ion battery recycling workflow. Although handheld XRF does not detect lithium, it can measure most elements from the periodic table including nickel or cobalt which often command much higher value than the lithium in a lithium-ion battery.⁴</p><h4><strong>Conclusion&nbsp;</strong></h4><p>There is no ideal process to recycle lithium-ion batteries that simultaneously incorporates low environmental impact, high metal recovery yield, and economic viability. Because of the variety of technologies and materials used, recycling lithium-ion batteries is a complex journey with multiple possible paths. HHXRF helps recyclers by generating lab-quality data in real time, allowing them to optimize their processes and make fast decisions that generate significant benefits:&nbsp;</p><ul><li>Unwanted materials containing heavy metals such as lead or cadmium can be prevented from entering subsequent steps in the recycling workflow.&nbsp;</li><li>Materials can be accurately sorted and adequate processes for recovery selected depending on the material type (e.g., LFP vs. MCM).&nbsp;</li><li>The economic value of incoming and outgoing material can be more accurately estimated.</li></ul><h3><strong>4. Waters Corporation: Waters Aura Systems</strong></h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/720009268_7b9ad02cb4.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The presentation introduces the <strong>Waters Aura Systems</strong>, a family of high-throughput, fluidics-free instruments for the characterization and identification of visible and subvisible particles. All Aura platforms provide particle counting, identification, morphology assessment, and flexible sample volumes ranging from microliters to milliliters. The portfolio includes configurations tailored to different applications: <strong>AuraBMI</strong> for biologics particle analysis, <strong>Aura</strong> for particle analysis with identification, <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2437"><strong>AuraPTx</strong></a> for protein formulation development, <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2438"><strong>AuraGT</strong></a> for gene therapy, <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2439"><strong>AuraCL</strong></a> for cell therapy, and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2190"><strong>Aura+</strong></a> as the most comprehensive platform. The systems are designed for automation-ready operation, straightforward method transfer, and continuity from research through QC.</p><p>A key feature of the Aura platform is the combination of <strong>Backgrounded Membrane Imaging (BMI), Fluorescence Membrane Microscopy (FMM), and Side Illumination Membrane Imaging (SIMI)</strong>. BMI captures particles on a membrane and subtracts the membrane background to improve particle contrast, while FMM uses fluorescent dyes or conjugated antibodies to distinguish specific particle types. This enables differentiation of protein aggregates, cells, viral capsids, degraded excipients, plastics, fibers, and other contaminants that may look similar based on morphology alone. SIMI adds further information for identifying unlabeled inorganic particles such as glass, fibers, and Dynabeads. Together, these techniques provide more specific particle identification than morphology-based classification alone.</p><p>The systems are particularly suited to <strong>biologics, gene therapy, and cell therapy development</strong>. For gene therapy, Aura can evaluate AAV stability, distinguish capsid-related particles, and monitor DNA leakage using SYBR Gold fluorescence, with measurements possible from as little as <strong>5 µL of sample</strong>. For cell therapy, the system can differentiate single cells, cell aggregates, protein aggregates, and extrinsic particles. The platform also supports flexible sample volumes and 24- or 96-well membrane formats, allowing the same general approach to be used from sample-limited early development through larger-volume and QC workflows. The brochure reports excellent quantitative linearity across serial dilutions and emphasizes the ability to preserve sample for additional orthogonal analyses.</p><p>From a technical perspective, Aura Systems provide <strong>100% sampling efficiency</strong>, a particle detection and quantitation range above <strong>1 µm</strong>, and can handle concentrations above <strong>3,000,000 particles/mL</strong> for 1.6 µm particles. Brightfield membrane imaging takes approximately <strong>one minute per sample</strong>, while fluorescence measurements require about <strong>15–30 seconds per sample</strong>. The instruments are compatible with robotic automation and offer different fluorescence-channel configurations depending on the selected Aura model. Overall, the platform is positioned as a comprehensive solution for obtaining quantitative particle counts together with information on particle identity and composition across the development and quality-control lifecycle.</p>

News from LabRulezICPMS Library - Week 36, 2026

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The Czech Academy of Sciences (CAS) was established by Act No. 283/1992 Coll. as the Czech successor of the former Czechoslovak Academy of Sciences. It is set up as a complex of 54 public research institutions.

Czech Academy of Sciences

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

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Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Phenomenex Biozen dSEC-1 LC columns

Phenomenex Biozen dSEC-1 is a high-resolution SEC column for peptide therapeutics, delivering fast, reproducible aggregate analysis with improved peak shape and compatibility with SEC-MS and SEC-MALS.

<h4><strong>High-Resolution Aggregate Analysis for Peptide Therapeutics</strong></h4><p>Biozen dSEC-1 columns are engineered to meet the growing demand for aggregate analysis in peptide therapeutics and mid-sized biologics. Packed with 90 Å small pore silica and featuring inert diol-based surface chemistry, dSEC-1 delivers enhanced resolution for low and high molecular weight peptide aggregates. Its robust design ensures reproducibility and compatibility with advanced workflows like SEC-MS and SEC-MALS.</p><h5><strong>Robust Performance for Peptide Aggregate Analysis</strong></h5><ul><li>High resolution for low/high MW peptide aggregates (1–50 kDa)</li><li>Reproducible, and fast analysis with extended column lifetime</li><li>Improved peak asymmetry by up to 40%</li><li><strong>Recommended Use: </strong>Analysis of peptides, protein fragments, and small biologics with reduced analysis times and improved column lifetimes.</li></ul><h4><strong>Aggregate and Monomer Separation in Liraglutide Formulations</strong></h4><ul><li>Baseline resolution of monomer and two aggregates achieved in under 10 minutes</li><li>Exceptional reproducibility with retention time RSD ≤ 0.08% and peak area RSD ≤ 0.01%</li><li>Clear detection at low levels with S/N ratios of 13, 75, and 10,917 for aggregates and monomer</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_separation_in_liraglutide_formulations_3_b0d97cd01f.jpg" alt="Phenomenex: Aggregate and Monomer Separation in Liraglutide Formulations" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_separation_in_liraglutide_formulations_3_b0d97cd01f.jpg 245w," sizes="100vw" width="938" height="307"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_separation_in_liraglutide_formulations_2_035bfea3bc.jpg" alt="Phenomenex: Aggregate and Monomer Separation in Liraglutide Formulations" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_separation_in_liraglutide_formulations_2_035bfea3bc.jpg 245w," sizes="100vw" width="1700" height="1050"></p><h3><strong>Biozen SEC Proprietary Silica Particle Technology</strong></h3><p>The Biozen dSEC columns are packed with low pore volume silica coupled with a proprietary hydrophilic diol-type bonded surface chemistry that prevents the silica surface from interacting with protein samples.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Biozen_SEC_Proprietary_Silica_Particle_Technology_502218b910.jpg" alt="Phenomenex: Biozen SEC Proprietary Silica Particle Technology" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Biozen_SEC_Proprietary_Silica_Particle_Technology_502218b910.jpg 245w," sizes="100vw" width="1448" height="469"></p><h4><strong>Improved Column Lifetime and Performance Stability</strong></h4><p>Phenomenex’s optimized SEC column loading technology has significantly improved the overall packing density and silica distribution of the columns leading to improved chromatographic lifetime and stability.</p><h4><strong>New Standard for Platform SEC Methods</strong></h4><p>Whether IgG2 or IgG4 isotypes, bispecifics, or Fc-Fusions, dSEC-2 provides excellent separation and sample recovery for many different classes of antibodies and related recombinant proteins.</p><h3><strong>Phenomenex Biozen Biologics LC Columns</strong></h3><p>With a new titanium <strong>BioTi™</strong> biocompatible <strong>hardware</strong> to minimize priming, <strong>four particle platforms</strong> for optimal versatility and <strong>nine particle chemistries</strong> to maximize selectivity and sensitivity, Biozen UHPLC/HPLC columns for <strong>protein analysis</strong> are seamlessly designed to bring peace of mind to your analysis of biologics through:</p><ul><li>Charge Variant Analysis</li><li>Aggregate Analysis</li><li>Peptide Mapping</li><li>Intact Mass Analysis</li><li>Intact and Subunit Analysis</li><li>Glycan Analysis</li><li>Peptide Quantitation</li><li>Drug Antibody Ratio (DAR)</li><li>Oligonucleotide Characterization</li></ul><h3><strong>Biocompatible Flow Path with BioTi™ Hardware</strong></h3><p>Keep your mind at ease knowing that we’ve minimized the need for priming with a new titanium infused biocompatible hardware and frit that doesn’t interfere with protein or peptide integrity!</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Bio_Ti_Hardware_991fb53395.jpg" alt="Phenomenex: BioTi Hardware" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Bio_Ti_Hardware_991fb53395.jpg 245w," sizes="100vw" width="1378" height="426"></p><h3><strong>4 Advanced Particle Platforms</strong></h3><p>All four of the Biozen particle platforms were individually designed and built by Phenomenex to take advantage of integral levels of performance, ruggedness, and reproducibility for protein characterization applications. Individually, each platform differs in the proprietary processing techniques used to control particle size and morphology.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Advanced_Particle_Platforms_a0959aca03.jpg" alt="Phenomenex: Advanced Particle Platforms" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Advanced_Particle_Platforms_a0959aca03.jpg 245w," sizes="100vw" width="1439" height="868"></p>

Phenomenex Clarity OTX Clean-Up

Rapid 15-minute clean-up of biological samples using Clarity OTX SPE enables efficient isolation of RNA- and DNA-based therapeutics without LLE, optimized for LC-MS bioanalysis.

<h4><strong>15 Minute Clean Up from Biological Samples</strong></h4><p><strong>Isolate RNA and DNA-based therapeutics / metabolites from biological fluids and tissues in less time with Clarity OTX solid phase extraction (SPE) and buffer products.</strong></p><ul><li>No liquid-liquid extraction (LLE) required required</li><li>&gt;80 % typical extraction recoveries</li><li>Optimized for LC-MS bioanalysis</li></ul><h3><app-cb-header style="color:rgb(65, 66, 69);font-family:proxima-nova, sans-serif;font-size:16px;font-style:normal;font-weight:400;letter-spacing:normal;text-align:left;text-indent:0px;text-transform:none;"><div><div><h2 style="border-bottom:1px solid rgb(51, 51, 51);color:rgb(0, 41, 72);font-size:32px;font-style:normal;font-weight:400;line-height:1.2;"><div>General Extraction</div></h2></div></div></app-cb-header><app-cb-fourtext-eightimage style="color:rgb(65, 66, 69);font-family:proxima-nova, sans-serif;font-size:16px;font-style:normal;font-weight:400;letter-spacing:normal;text-align:left;text-indent:0px;text-transform:none;"><div><div><div style="flex-wrap:wrap;"><div style="flex:0 0 100%;"><h2 style="color:rgb(0, 41, 72);font-size:32px;font-weight:400;line-height:1.2;">Common Extraction Procedure (~180 minutes)</h2></div></div></div></div></app-cb-fourtext-eightimage><strong>General Extraction</strong></h3><h4><strong>Common Extraction Procedure (~180 minutes)</strong></h4><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Clarity_OTX_Clean_Up_e317411382.jpg" alt="Phenomenex: Clarity OTX Clean-Up: Common Extraction Procedure (~180 minutes)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Clarity_OTX_Clean_Up_e317411382.jpg 245w," sizes="100vw" width="678" height="374"></p><h5><strong>Suitable for Most Oligo Therapeutics &amp; Samples</strong></h5><p><strong>Oligo types / Sample Types</strong></p><ul><li>DNA: Plasma</li><li>Aptamers: Serum</li><li>RNAi/siRNA: Urine</li><li>Thioates: Tears</li><li>Lipid-conjugates: Saliva</li><li>Liposome encapsulated: Tissue</li></ul><h4><strong>Extraction Protocol</strong></h4><p><strong>Sample Pre-Treatment</strong></p><ul><li><strong>Tissue:</strong><ul><li>Proteinase K digestion or homogenize</li><li>Mix 1-to-1 with Lysis-Loading buffer</li></ul></li><li><strong>Biological Fluids: </strong>Mix 1-to-1 with Lysis-Loading buffer</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Clarity_OTX_Clean_Up_2_fd322c63cd.jpg" alt="Phenomenex: Clarity OTX Clean-Up: Extraction Protocol" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Clarity_OTX_Clean_Up_2_fd322c63cd.jpg 245w," sizes="100vw" width="1031" height="494"></p>

Phenomenex Zebron Z-Guard GC Columns

Phenomenex Zebron Z-Guard GC columns protect analytical columns, improve peak shape and sensitivity, and extend column lifetime. Individually QC tested.

<h4><strong>Protect and Extend Column Lifetime</strong></h4><ul><li>Individually QC tested to ensure the highest level of quality</li><li>Extend column lifetime by preventing stationary phase damage</li><li>Improve separation and peak shapes (especially early elutors)</li><li>Improve sensitivity and accuracy of quantitative results</li><li>Available as individual guard columns or as complete kits with connectors</li></ul><p>To ensure that all Z-Guards are the highest possible quality, we individually test each one! The columns are attached to a reference <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/1577"><strong>Zebron ZB-5 column</strong></a> and are tested using our specially designed QC mix. We carefully monitor activity, bleed, and stability. This way, we are able to say with confidence that Z-Guards will provide the low activity and high quality your methods require.</p><h5><strong>Recommended Use</strong></h5><p>Extends column lifetime by preventing stationary phase damage and improves separation, peak shapes (especially early elutors), sensitivity, and accuracy of quantitative results</p><h4><strong>Zebron Z-Guard Phase Information</strong></h4><p>Z-Guard columns are universal GC guard columns, designed for use with virtually any GC capillary column, from virtually any manufacturer.</p><ul><li>Extend column lifetime by preventing stationary phase damage</li><li>Improve separation, peak shapes (especially early elutors), sensitivity, and accuracy of quantitative results</li><li>Alternative to Agilent, Restek, Supelco, and many more</li></ul><h5><strong>Easy Use Z-Guard Column Kits</strong></h5><p>Try Z-Guard columns individually or get the convenient, complete kit. Each kit includes:</p><ul><li>5 or 10 meters of deactivated fused-silica tubing</li><li>5 universal connectors</li><li>0.5 mL of high-temperature polyimide resin</li></ul><h5><strong>Guard Column Usage</strong></h5><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Zebron_Z_Guard_GC_Columns_Guard_column_usage_675cd327b8.jpg" alt="Phenomenex: Zebron Z-Guard GC Columns: Guard column usage" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Zebron_Z_Guard_GC_Columns_Guard_column_usage_675cd327b8.jpg 245w," sizes="100vw" width="1039" height="359"></p><h5><strong>Tips: Using Z-Guard Columns</strong></h5><p>When using a guard at high temperatures, make sure that the press-fit connection is secure.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Zebron_Z_Guard_GC_Columns_Using_Z_guard_columns_6842e6a4bd.jpg" alt="Phenomenex: Zebron Z-Guard GC Columns: Using Z-guard columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Zebron_Z_Guard_GC_Columns_Using_Z_guard_columns_6842e6a4bd.jpg 245w," sizes="100vw" width="414" height="164"></p><p>The most important aspect of a good seal is a good column cut.</p><ul><li>The column end should be square and smooth (like a straw). Any irregularities will cause leaks.</li><li>Columns are long - repeat cutting until a good cut is achieved.</li><li>Lightly scoring the column usually creates a cleaner opening.</li></ul>

Phenomenex Phenex LC/GC Approved Syringe Filters

Phenex syringe filters deliver fast, reliable sample filtration with excellent flow rates and broad chemical compatibility. Designed to protect columns, reduce downtime, and ensure particulate-free samples for LC, GC, and MS analysis.

<p><strong>Phenex syringe filters are designed for efficient and rapid filtration of almost any solution prior to analysis, and are optimized for superior flow rates and high-throughput. Proper syringe filter membrane and size selection is the key to choosing the best product to maintain the integrity of your sample components as well as to protect your system from particulate contamination. Phenex offers a wide variety of membranes ideal for any application.</strong></p><h5><strong>Try our Phenex Syringe Filters for:</strong></h5><ul><li>High quality filtration product</li><li>Increased column lifetime</li><li>Less system downtime</li><li>Low protein absorption</li></ul><h4><strong>Phenex Offers:</strong></h4><ul><li>Broad chemical compatibility</li><li>Minimized extractables</li><li>Excellent flow rate</li><li>High total throughput</li><li>Certified quality</li><li>100 % integrity tested</li><li>Low hold-up volume</li><li>Low protein adsorption</li><li>Bi-directional use</li></ul><h3><strong>Maximum Quality</strong></h3><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Phenex_LC_GC_Approved_Syringe_Filters_2_44145fa074.jpg" alt="Phenomenex: Phenex LC-GC Approved Syringe Filters: Maximum Quality" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Phenex_LC_GC_Approved_Syringe_Filters_2_44145fa074.jpg 218w," sizes="100vw" width="1156" height="828"></p><h5><strong>A: Identification</strong></h5><ul><li>Syringe filter membrane type and pore size are clearly marked on each syringe filter</li></ul><h5><strong>B: Luer Lock Inlet Tip</strong></h5><ul><li>Secures connections to prevent “blow off”</li></ul><h5><strong>C: Sample Distribution Rings</strong></h5><ul><li>Creates even sample distribution for high sample flow rates</li></ul><h5><strong>D: Medical Grade Polymer Housing</strong></h5><p>Offers the most inert syringe filter and helps eliminate unwanted secondary interactions with the filter housing</p><h5><strong>E: Ultrasonically Welded</strong></h5><ul><li>Ensures robust housing - filter integrity</li></ul><h4><strong>Guaranteed Reliability and Consistency</strong></h4><p>Quality filtration products from Phenomenex offer a convenient way to clean up your samples - for improved analytical results with a simple method. Phenex syringe filters are designed for efficient and rapid filtration of almost any solution prior to analysis, and are optimized for superior flow rates and high-throughput. Phenex offers a wide variety of membranes ideal for any application.</p><ul><li>High quality filtration product</li><li>Increased column lifetime</li><li>Less system downtime</li></ul><p>The housing attaches to any standard luer lock syringe, so the sample can easily be pushed through the membrane with minimal pressure. The result is a particulate-free eluent that is ready for use with LC, GC, or other analytical techniques. One of the most popular sample preparation methods is filtration using a sample preparation solution. It has the ability to remove particulates before injection onto the column and the ability to use it in parallel with another sample preparation technique. It requires no method development.</p><ul><li><strong>A:</strong> Particulates Trapped</li><li><strong>B:</strong> Particulate-free Sample</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Phenex_LC_GC_Approved_Syringe_Filters_631acccb54.jpg" alt="Phenomenex: Phenex LC/GC Approved Syringe Filters: Guaranteed Reliability and Consistency" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Phenex_LC_GC_Approved_Syringe_Filters_631acccb54.jpg 42w," sizes="100vw" width="143" height="523"></p><h3><strong>Recommendation Based on Your Industry</strong></h3><h5><strong>Environmental</strong></h5><p>Water, wastewater, soil and sludge, and pollution control samples are especially challenging. No matter the sample type, Phenex offers filtration products to meet your demanding requirements.</p><ul><li><strong>Recommended Filter: </strong>GF/NY</li><li><strong>First Alternative:</strong> RC</li></ul><h5><strong>Pharmaceutical / Biotech</strong></h5><p>At every stage of the drug discovery process target compounds must be isolated, purified, and prepared prior to testing. Sample complexity in DMPK work can be even more challenging. Difficult samples such as serum, urine, and other physiological fluids are easily filtered and clarified using Phenex syringe filters.</p><ul><li><strong>Recommended Filter: </strong>PES</li><li><strong>First Alternative: </strong>RC</li></ul><h5><strong>Clinical / Toxicology</strong></h5><p>Removal of particulate matter to sub-micron levels is critical before any clinical sample is injected into an LC, GC or mass spectrometer. At every stage in toxicology, samples should be filtered, preferably with a rapid and simple sample preparation method to reduce downtime in the fast paced environment. Phenex is designed for higher flow rates and throughputs than those of competing products.</p><ul><li><strong>Recommended Filter: </strong>RC</li><li><strong>First Alternative: </strong>PES</li></ul><h5><strong>Food and Beverage</strong></h5><p>Food safety is more important than ever and lower detection limits are making analysis even more challenging. Accurate and reliable testing is critical and Phenex filters are routinely used in preparation for analysis of pesticides, herbicides, fungicides, flavors, and fragrances. For samples with large amounts of particulate and/or large fibrous matter, use a glass fiber prefilter.</p><ul><li><strong>Recommended Filter: </strong>GF/NY</li><li><strong>First Alternative: </strong>RC</li></ul><h3><strong>How to Use Phenex Syringe Filters</strong></h3><h4><strong>Easy to assemble and even easier to get consistent and particulate-free samples</strong></h4><h5><strong>Step 1: Load</strong></h5><ul><li>Fill a syringe barrel with the liquid sample. Allow a small amount of air (approximately 10 % of the sample volume) to enter the syringe. The air is used as a purge to minimize fluid retention when expelling the sample from the syringe (Step 3 below).</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Phenex_LC_GC_Approved_Syringe_Filters_Step_1_f8246ba832.jpg" alt="Phenomenex: Phenex LC/GC Approved Syringe Filters - Step 1: Load" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Phenex_LC_GC_Approved_Syringe_Filters_Step_1_f8246ba832.jpg 155w," sizes="100vw" width="423" height="427"></p><h5><strong>Step 2: Assemble</strong></h5><ul><li>Twist the luer lock end of the filter securely onto the syringe.</li><li><strong>Caution: </strong>Do not use syringes without a matching luer lock, otherwise the pressure applied may cause the filter to come off unexpectedly.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Phenex_LC_GC_Approved_Syringe_Filters_Step_2_2833584d34.jpg" alt="Phenomenex: Phenex LC/GC Approved Syringe Filters: Step 2: Assemble" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Phenex_LC_GC_Approved_Syringe_Filters_Step_2_2833584d34.jpg 158w," sizes="100vw" width="349" height="344"></p><h5><strong>Step 3: Filter</strong></h5><ul><li>Apply gentle pressure to the syringe plunger.</li><li><strong>Caution: </strong>Small syringes can generate excessive pressures.) Push the liquid sample, as well as the remaining air, through the syringe filter to maximize sample recovery.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Phenex_LC_GC_Approved_Syringe_Filters_Step_3_d8c5f61231.jpg" alt="Phenomenex: Phenex LC/GC Approved Syringe Filters - Step 3: Filter" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Phenex_LC_GC_Approved_Syringe_Filters_Step_3_d8c5f61231.jpg 177w," sizes="100vw" width="375" height="331"></p>

KNAUER Sepapure oliGO 120-3 Column

KNAUER Sepapure oliGO 120-3 column for oligonucleotide analysis in RP and IP-RP modes with UHPLC performance and low back pressure.

<p><strong>The KNAUER Sepapure® oliGO 120-3 is a high-performance HPLC/UHPLC column optimized for oligonucleotide analysis in both reversed-phase (RP) and ion-pair reversed-phase (IP-RP) modes.</strong></p><p>The column is based on <strong>hybrid silica with advanced endcapping and hydrophobic modification</strong>, ensuring <strong>stable interactions, high reproducibility, and long lifetime</strong>, even under demanding conditions.</p><p>With <strong>3 µm particles</strong>, the column delivers <strong>UHPLC performance</strong> while maintaining <strong>low back pressure</strong>, allowing use even on standard HPLC systems.</p><p>It is ideal for:</p><ul><li><strong>identification</strong></li><li><strong>quantification</strong></li><li><strong>quality control (QC)</strong><br>of oligonucleotides.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Sepapure_oli_GO_120_3_Column_3_e306727053.jpg" alt="KNAUER: Sepapure oliGO 120-3 Column" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Sepapure_oli_GO_120_3_Column_3_e306727053.jpg 245w," sizes="100vw" width="882" height="478"></p><h4><span><strong>Key Features</strong></span></h4><ul><li>Optimized for oligonucleotides</li><li>Supports <strong>RP and IP-RP modes</strong></li><li>UHPLC performance with low back pressure</li><li><strong>3 µm particles </strong>for high resolution</li><li><strong>18% carbon load</strong></li><li><strong>Wide pH range (1.5–10)</strong></li><li>High chemical stability</li><li>Compatible with standard HPLC systems</li><li>High reproducibility and robustness</li><li>Suitable for extreme pH and temperature conditions</li></ul><h3><span><strong>Technical Specifications</strong></span></h3><h4><span><strong>General</strong></span></h4><ul><li><strong>Separation modes:</strong> RP / IP-RP</li><li><strong>Endcapping:</strong> Yes</li><li><strong>USP classification: </strong>L1</li><li><strong>Connection:</strong> 1/16"</li></ul><h4><span><strong>Column Parameters</strong></span></h4><ul><li><strong>Particle size:</strong> 3 µm</li><li><strong>Pore size:</strong> 120 Å</li><li><strong>Surface area:</strong> 300 m²/g</li><li><strong>Carbon load:</strong> 18%</li></ul><h4><span><strong>Operating Conditions</strong></span></h4><ul><li><strong>pH range:</strong> 1.5 – 10</li><li><strong>Max pressure:</strong> 413 bar</li><li><strong>Max temperature:</strong> 60 °C</li></ul><h3><span><strong>Technology Advantages</strong></span></h3><h4><span><strong>Low Back Pressure</strong></span></h4><ul><li>enables <strong>UHPLC performance on HPLC systems</strong></li><li><strong>protects instrumentation</strong></li><li>reduces <strong>wear and clogging</strong></li><li>minimizes <strong>oligonucleotide aggregation</strong></li></ul><h4><span><strong>IP-RP Optimization</strong></span></h4><ul><li>ideal <strong>pH range: 7.0 – 9.5</strong></li><li>combines <strong>hydrophobic and ionic interactions</strong></li><li>enables <strong>high-resolution separation</strong></li></ul><h4><span><strong>Cost-effective Hardware</strong></span></h4><ul><li>no need for inert hardware</li><li>optimized for <strong>routine analytical use</strong></li><li>tested with no impact on performance</li></ul><h4><span><strong>Typical Applications</strong></span></h4><ul><li>Oligonucleotide analysis</li><li>Biopharmaceutical QC</li><li>Polar molecule analysis</li><li>Method development (extreme pH/temperature)</li></ul>

KNAUER Sepapure Laboratory Filtration

Sepapure laboratory filtration includes syringe filters, membranes, and filter units for clean, precise, and reproducible results.

<p><strong>The Sepapure® Laboratory Filtration range provides a comprehensive solution for laboratory sample filtration, focusing on purity, precision, and reproducibility.</strong></p><p>The portfolio includes:</p><ul><li><strong>syringe filters</strong></li><li><strong>membrane disc filters</strong></li><li><strong>filter units</strong></li><li><strong>filter holders</strong></li></ul><p>These products are designed to ensure <strong>maximum sample recovery, minimal loss, and broad compatibility</strong> across analytical, pharmaceutical, and routine laboratory applications.</p><h4><span><strong>Key Features</strong></span></h4><ul><li>High filtration purity and reproducibility</li><li>Minimal sample loss</li><li>Color-coded identification</li><li>Wide range of membrane materials</li><li>Broad application compatibility</li><li>Pressure resistance (&gt;6 bar)</li><li>Eco-friendly reusable solutions</li></ul><h3><span><strong>Product Variants</strong></span></h3><h4><span><strong>Sepapure® Syringe Filters</strong></span></h4><ul><li>Color-coded and labeled</li><li>Integrated polypropylene prefilter</li><li>Low hold-up volume → minimal sample loss</li><li>High pressure resistance (&gt;6 bar)</li><li>Wide application compatibility</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Sepapure_Laboratory_Filtration_5_00f6e96bbe.jpg" alt="KNAUER: Sepapure® Syringe Filters" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Sepapure_Laboratory_Filtration_5_00f6e96bbe.jpg 245w," sizes="100vw" width="1216" height="196"></p><h4><span><strong>Sepapure® Membrane Disc Filters</strong></span></h4><ul><li>Various membrane materials</li><li>Efficient separation for complex samples</li><li>High filtrate purity</li><li>Suitable for lab and research use</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Sepapure_Laboratory_Filtration_3_1e207905e0.jpg" alt="KNAUER: Sepapure® Membrane Disc Filters" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Sepapure_Laboratory_Filtration_3_1e207905e0.jpg 156w," sizes="100vw" width="1000" height="1000"></p><h4><span><strong>Filter Units (Glass Vacuum Units)</strong></span></h4><ul><li>Glass vacuum filtration systems</li><li>Available volumes: 1000 mL and 2000 mL</li><li>Ground glass or rubber joints</li><li>Compatible with membrane filters</li><li>High chemical resistance and durability</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Sepapure_Laboratory_Filtration_2_86cf0cc5f8.jpg" alt="KNAUER: Filter Units (Glass Vacuum Units)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Sepapure_Laboratory_Filtration_2_86cf0cc5f8.jpg 156w," sizes="100vw" width="1000" height="1000"></p><h4><span><strong>Filter Holders</strong></span></h4><ul><li>Reusable and durable</li><li>Eco-friendly (waste reduction)</li><li>Versatile applications</li><li>High mechanical stability</li></ul><h4><span><strong>Typical Applications</strong></span></h4><ul><li>Sample preparation for HPLC/LC-MS</li><li>Mobile phase filtration</li><li>Environmental analysis</li><li>Pharmaceutical QC</li><li>Biochemical and clinical workflows</li></ul>

KNAUER Vials & Caps

KNAUER vials and caps for HPLC/UHPLC with high chemical resistance, multiple closure types, and optimized solutions for precise sample handling.

<p><strong>The KNAUER Vials &amp; Caps range provides a complete solution for sample preparation in HPLC/UHPLC analysis, where precision, purity, and sample integrity are critical.</strong></p><p>Selecting the correct vial and cap combination directly impacts:</p><ul><li><strong>result reproducibility</strong></li><li><strong>contamination prevention</strong></li><li><strong>minimization of evaporation</strong></li><li><strong>autosampler performance</strong></li></ul><p>KNAUER offers a wide variety of configurations including:</p><ul><li>glass types (clear / amber)</li><li>closure types (screw, crimp, snap)</li><li>septa (pre-slit / non pre-slit)</li><li>accessories (µ-inserts for small volumes)</li></ul><h3><span><strong>Product Variants</strong></span></h3><h4><span><strong>Sample Vials</strong></span></h4><ul><li><strong>Neck types:</strong><ul><li>screw neck</li><li>crimp neck</li><li>snap ring</li></ul></li><li><strong>Materials:</strong><ul><li>clear glass</li><li>amber glass (UV protection)</li></ul></li><li>High chemical resistance</li><li>Compatible with micro-inserts</li></ul><h4><span><strong>Caps</strong></span></h4><ul><li>Compatible with all vial types</li><li><strong>Options:</strong><ul><li>pre-slit septa</li><li>solid septa</li></ul></li><li>Optimized sealing</li><li>Suitable for automated and manual sampling</li></ul><h3><span><strong>Vial Selection Guide</strong></span></h3><h4><span><strong>Glass Color</strong></span></h4><ul><li><strong>Amber glass</strong><ul><li>UV protection</li><li>ideal for <strong>light-sensitive compounds (vitamins, steroids, pharmaceuticals)</strong></li></ul></li><li><strong>Clear glass</strong><ul><li>maximum visibility</li><li>ideal for <strong>routine applications</strong></li></ul></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Vials_and_Caps_glass_color_bd1238185e.jpg" alt="KNAUER: Vials &amp; Caps - Glass color" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Vials_and_Caps_glass_color_bd1238185e.jpg 155w," sizes="100vw" width="435" height="437"></p><h4><span><strong>Closure Types</strong></span></h4><ul><li><strong>Screw Neck</strong><ul><li>resealable</li><li>ideal for <strong>volatile samples and storage</strong></li></ul></li><li><strong>Crimp Neck</strong><ul><li>tightest seal</li><li>ideal for <strong>highly volatile samples</strong></li></ul></li><li><strong>Snap Ring</strong><ul><li>tool-free handling</li><li>suitable for <strong>short-term use</strong></li></ul></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Vials_and_Caps_closure_type_c6c7a61418.jpg" alt="KNAUER: Vials &amp; Caps - Closure type" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Vials_and_Caps_closure_type_c6c7a61418.jpg 245w," sizes="100vw" width="978" height="389"></p><h4><span><strong>Septum Types</strong></span></h4><ul><li><strong>Pre-slit septum</strong><ul><li>easier needle penetration</li><li>ideal for <strong>autosamplers</strong></li><li>prevents vacuum formation</li></ul></li><li><strong>Non pre-slit septum</strong><ul><li>tighter seal</li><li>ideal for <strong>storage and evaporation control</strong></li></ul></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Vials_and_Caps_septum_type_0b6afde0e9.jpg" alt="KNAUER: Vials &amp; Caps - Septum type" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Vials_and_Caps_septum_type_0b6afde0e9.jpg 245w," sizes="100vw" width="551" height="343"></p><h4><span><strong>µ-Inserts (Small Volumes)</strong></span></h4><ul><li>Reduce sample volume requirements</li><li>Maximize recovery</li><li>Ideal for valuable or limited samples</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Vials_and_Caps_3_b697f0f41b.webp" alt="KNAUER: Vials &amp; Caps - Micro inserts" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Vials_and_Caps_3_b697f0f41b.webp 239w," sizes="100vw" width="1000" height="653"></p>

KNAUER Capillaries & Tubing

KNAUER Capillaries & Tubing provide high-pressure LC capillaries and tubing up to 1200 bar, including MarvelXACT™ tool-free UHPLC connection systems.

<p><strong>KNAUER Capillaries &amp; Tubing provide a wide range of capillaries and tubing solutions for analytical and preparative HPLC, UHPLC, and FPLC applications. The portfolio includes stainless steel, PEEK, PTFE, and other tubing materials designed for reliable LC connections at pressures up to 1200 bar. The range also features innovative MarvelXACT™ capillaries with tool-free fingertight connections and a patented torque-limiting mechanism for secure and trouble-free operation.</strong></p><h4><span><strong>Key Features</strong></span></h4><ul><li>Capillaries and tubing for HPLC, UHPLC, and FPLC</li><li>Maximum pressure up to 1200 bar</li><li>Materials include stainless steel, PEEK, PTFE, PFA, ETFE, and more</li><li>Suitable for analytical and preparative applications</li><li>MarvelXACT™ fingertight connection system</li><li>Patented torque-limiting “click” mechanism</li><li>Automatic adjustment to different port depths</li><li>More than 100 connection/disconnection cycles</li><li>PEEK capillaries for maximum biocompatibility</li><li>User-cuttable standard capillaries</li><li>Tubing for low-pressure solvent and waste lines</li></ul><h4><span><strong>MarvelXACT™ Capillaries</strong></span></h4><ul><li>Recommended for AZURA® Analytical systems</li><li>Tool-free installation</li><li>Flexible 1/32” OD tubing</li><li>compatible with KNAUER standard 1/16” receiving ports</li><li>Pre-installed fittings</li><li>Eliminates under- and over-tightening</li><li>Patented torque-limiting mechanism</li><li>Flexible tubing for easy routing</li><li>Bottom-port sealing without ferrules</li></ul><h4><span><strong>Available Options</strong></span></h4><ul><li>Stainless steel capillaries for high-pressure applications</li><li>PEEK capillaries for biocompatible workflows</li><li>PTFE, PFA, ETFE, and Tefzel® tubing</li><li>User-customizable capillary lengths</li><li>Tubing for solvent and waste connections</li></ul>

KNAUER Pipettes

KNAUER Pipetting Solutions combine ergonomic BlueOrchid pipettes, high-purity pipette tips, reload systems, and sustainable rack boxes for accurate, comfortable, and contamination-free liquid handling workflows.

<p><strong>KNAUER Pipetting Solutions combine ergonomic design, precision engineering, and high-quality consumables to support reliable liquid handling workflows in analytical, biological, and routine laboratory applications. The portfolio includes BlueOrchid micropipettes, premium pipette tips, reload systems, and sustainable rack boxes designed to deliver maximum accuracy, user comfort, and workflow efficiency.</strong></p><h4><span><strong>BlueOrchid Pipettes</strong></span></h4><p>KNAUER BlueOrchid pipettes are designed for effortless daily pipetting with reduced hand strain and reliable long-term performance. The lightweight and balanced construction, combined with a silicone-based shock absorption mechanism and magnet-assisted piston system, minimizes pipetting and tip ejection forces for fatigue-free operation.</p><p>The pipettes feature intuitive one-handed volume adjustment with a secure locking mechanism and a large 4-digit display for easy readability. All models are ISO 8655-6 calibrated to ensure high accuracy and precision.</p><p><strong>Available single-channel volume ranges include:</strong></p><ul><li>0.1–2.5 µL</li><li>0.5–10 µL</li><li>2–20 µL</li><li>5–50 µL</li><li>10–100 µL</li><li>20–200 µL</li><li>100–1,000 µL</li><li>500–5,000 µL</li><li>1,000–10,000 µL</li><li>Fixed-volume 150 µL model</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Pipettes_6_3d401a1c67.jpg" alt="KNAUER: Pipettes" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Pipettes_6_3d401a1c67.jpg 241w," sizes="100vw" width="1046" height="677"></p><p><strong>Key characteristics:</strong></p><ul><li>Ergonomic low-force pipetting design</li><li>Color-coded volume identification</li><li>Autoclavable and chemically resistant construction</li><li>UV-resistant materials</li><li>No recalibration required after sterilization</li><li>Compatible with KNAUER pipette tips and many third-party brands</li></ul><h4><span><strong>Pipette Tips</strong></span></h4><p>KNAUER pipette tips are manufactured in Germany from high-quality medical-grade virgin polypropylene to ensure contamination-free and highly reproducible pipetting. The product range includes eight <strong>tip sizes from 10 µL to 10 mL</strong>, including <strong>extra-long 10 µL tips</strong> optimized for recovery of very small sample volumes.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Pipette_Tips_71e87b2e4b.webp" alt="KNAUER: Pipette Tips" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Pipette_Tips_71e87b2e4b.webp 100w," sizes="100vw" width="690" height="1077"></p><p>The tips are designed with optimized cone geometry for secure pipette fitting and low-force attachment and ejection. A conical tip opening and ultra-smooth internal surface reduce droplet formation and minimize sample retention.</p><p><strong>Key advantages:</strong></p><ul><li>Free of DNase, RNase, human DNA, pyrogens, and PCR inhibitors</li><li>Autoclavable and non-wettable</li><li>US FDA-approved virgin polypropylene</li><li>Universal compatibility with major pipette brands</li><li>Graduation marks for rapid volume verification</li><li>Available in bulk bags or reload systems</li><li>Yellow and blue versions available for selected tip sizes</li></ul><p><strong>Available packaging options:</strong></p><ul><li>Bulk bags for economical refilling</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Bulk_Bags_f99e73dba3.webp" alt="KNAUER: Bulk Bags" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Bulk_Bags_f99e73dba3.webp 156w," sizes="100vw" width="690" height="690"></p><ul><li>Reload units for fast one-handed box refilling and reduced plastic waste</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Reloads_48b0e2cf9d.webp" alt="KNAUER: Reload units" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Reloads_48b0e2cf9d.webp 245w," sizes="100vw" width="690" height="343"></p><h4><span><strong>Reload Systems</strong></span></h4><p>KNAUER reload systems are designed to simplify laboratory workflows while reducing environmental impact. <strong>Reloads</strong> are available for <strong>10 µL, 200 µL, and 1,000 µL pipette tips</strong> and allow quick replacement of empty rack inserts with minimal handling effort.</p><p><strong>Advantages of reload systems:</strong></p><ul><li>One-handed reload operation</li><li>Reduced plastic consumption</li><li>Space-saving storage</li><li>Color-coded rack inserts for quick identification</li><li>Optimized for routine high-throughput workflows</li></ul><h4><span><strong>Rack Boxes</strong></span></h4><p>KNAUER rack boxes provide secure and sustainable storage for pipette tips. The boxes are manufactured from 100% recycled plastic sourced from pipette tip production and are fully autoclavable.</p><p>The stackable design allows safe and space-efficient storage, while the easy-open lid and color-coded rack inserts improve laboratory organization and workflow efficiency.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Tip_boxes_1d59517540.webp" alt="KNAUER: Rack boxes" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Tip_boxes_1d59517540.webp 245w," sizes="100vw" width="1024" height="427"></p><p><strong>Available rack box versions:</strong></p><ul><li>10 µL / 10 µL XL pipette tips</li><li>200 µL / 300 µL pipette tips</li><li>1,000 µL pipette tips</li><li>1,250 µL pipette tips</li></ul><p><strong>Key features:</strong></p><ul><li>Made from 100% recycled plastic</li><li>Stackable construction</li><li>Secure tip positioning</li><li>Easy one-handed handling</li><li>Compatible with single- and multi-channel pipettes</li><li>Sustainable and reusable design</li></ul>

Phenomenex Luna Omega HILIC HPLC Columns

Phenomenex Luna Omega HILIC combines a bonded diol phase with fully porous particles for superior retention and selectivity of polar analytes in HILIC applications.

<p><strong>Luna Omega HILIC columns combine thermally modified fully porous particles with a bonded diol stationary phase to provide enhanced retention and selectivity for polar analytes under HILIC conditions. Designed for small polar molecules, metabolites, nucleobases, pharmaceuticals, and other challenging compounds, these columns deliver excellent chromatographic performance and robustness.</strong></p><p>The diol stationary phase provides multiple interaction mechanisms that improve retention and separation of polar compounds while maintaining excellent peak shape and reproducibility. The thermally modified fully porous particles extend column lifetime and ensure reliable performance across demanding analytical workflows.</p><h3><strong>Technical Specifications</strong></h3><h4><strong>Stationary Phase</strong></h4><ul><li><strong>Phase: </strong>Diol</li><li><strong>USP Classification:</strong> L20</li></ul><h4><strong>Particle Characteristics</strong></h4><ul><li><strong>Particle Sizes:</strong><ul><li>1.6 µm</li><li>3 µm</li></ul></li><li><strong>Pore Size:</strong> 100 Å</li><li><strong>Surface Area:</strong> 260 m²/g</li><li><strong>Carbon Load:</strong> 5 %</li></ul><h4><strong>Chemical Properties</strong></h4><ul><li><strong>pH Range: </strong>2.0–7.0</li><li><strong>Maximum Pressure: </strong>1034 bar (15,000 psi)</li></ul><h4><strong>Available Dimensions</strong></h4><ul><li><strong>Lengths:</strong><ul><li>50 mm</li><li>100 mm</li><li>150 mm</li><li>250 mm</li></ul></li><li><strong>Internal Diameters:</strong><ul><li>2.1 mm</li><li>3.0 mm</li><li>4.6 mm</li></ul></li></ul><h4><strong>Typical Applications</strong></h4><ul><li>HILIC separations</li><li>Nucleobases</li><li>Nucleotides</li><li>Metabolomics</li><li>Pharmaceutical analysis</li><li>Bioanalytical workflows</li><li>Food analysis</li><li>Environmental testing</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Luna_Omegs_HILIC_b02079eee2.jpg" alt="Phenomenex: Separation of Nucleobases with Luna Omega 3μm HILIC.  1. Thymine 2. Uracil 3. Adenine 4. Cytosine 5. Guanine" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Luna_Omegs_HILIC_b02079eee2.jpg 245w," sizes="100vw" width="1284" height="648"></p><h3><strong>Phenomenex Luna Omega HPLC/UHPLC Columns</strong></h3><p>The cutting edge thermally modified Luna Omega particle delivers high efficiency, ruggedness, reproducibility, and dependability for a wide range of chromatographic analyses. Luna Omega HPLC and UHPLC columns are built upon more then 20 years of applied knowledge, invention, and customer experience in the manufacture and packing of LC columns. The particle’s novel design and proprietary manufacturing process results in greater particle inertness, a stronger particle morphology, and more consistent porosity.</p><ul><li>Greater separation muscle and retention</li><li>Consistent porous structure and elimination of micropores</li><li>Extreme ruggedness and reproducibility</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_Thermal_modified_pore_structure_of_Luna_Omega_Column_particles_37138bb135.jpg" alt="Phenomenex:Thermal modified pore structure of Luna Omega Column particles" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_Thermal_modified_pore_structure_of_Luna_Omega_Column_particles_37138bb135.jpg 245w," sizes="100vw" width="1257" height="369"></p><h3><strong>Explore Luna Omega Columns</strong></h3><h5><strong>Astounding Performance</strong></h5><p>The undeniably high efficiency levels found in each Luna Omega UHPLC column provide you with the potential of huge gains in method performance. While traditional silica and hybrid fully porous particles claim high performance, when compared to Luna Omega 1.6 μm, they drastically fall short and prevent UHPLC scientists from reaching their UHPLC potential.</p><h5><strong>Separation Muscle</strong></h5><p>Our industry leading bonding technologies in conjunction with high efficiency levels ensure excellent stationary phase coverage and improved separation power. Now, with Luna Omega 1.6 μm, you can turn difficult separations into resolution achievements.</p><h5><strong>Inert Foundation</strong></h5><p>Luna Omega UHPLC columns contain a unique silica modified using a proprietary, post-synthetic thermal treatment process to provide extraordinary mechanical strength and significantly greater inertness than traditional fully porous and hybrid materials. This greatly minimizes secondary interactions that negatively affect peak shape, allowing for greater method accuracy.</p><h5><strong>Consistent Results</strong></h5><p>Batch-to-batch and column-to-column, Luna® Omega media and columns are designed to be consistent and incredibly accurate tools for your analysis. Each batch and column are quality tested to ensure dependability and reproducibility.</p>

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