<p><strong>Taťána Gazárková is currently a&nbsp;postdoctoral fellow in the Laboratory of Antibiotic Resistance and Microbial Metabolomics. During her doctoral studies, she focused on chromatography and mass spectrometry. Recently, she was awarded second place in the “Sanofi Prize for Pharmacy 2026” competition.</strong></p><p><strong>Taťána Gazárková </strong>is currently a&nbsp;postdoctoral fellow in the <strong>Laboratory of Antibiotic Resistance and Microbial Metabolomics</strong>. During her doctoral studies, she focused on chromatography and mass spectrometry. Recently, she was awarded second place in the <strong>“Sanofi Prize for Pharmacy 2026” </strong>competition, which is awarded by the<strong> French Embassy in the Czech Republic</strong> for her dissertation – Steroid Analysis Using Modern Chromatographic and Mass Spectrometry Techniques: From Fundamental Studies to Targeted Bioanalytical Applications (supervisor: <strong>Lucie Nováková, Charles University</strong>).&nbsp;</p><h5><strong>What makes this field particularly exciting or unique in your view?</strong></h5><p>What I&nbsp;enjoy about analytical chemistry is that, to a&nbsp;certain extent, it is a&nbsp;kind of detective work. You are often looking for ways to “make the invisible visible”. In other words, extract the information you are interested in from a&nbsp;complex sample and then interpret it correctly. What also appeals to me about bioanalytical chemistry is its interdisciplinary nature. It brings together analytical chemistry, biochemistry, biology and medicine, which means that you need to be able not only to translate a&nbsp;biological or clinical question into a&nbsp;measurable analytical experiment, but also to place the resulting data back into a&nbsp;broader biological context. This combination of different perspectives is probably what I&nbsp;enjoy most about the field. At the same time, there is still plenty of room for fundamental research, ranging from studying analytical techniques themselves and improving them to developing new methodological approaches.</p><h5><strong>How did you end up at the </strong><a target="_blank" rel="noopener noreferrer" href="https://mbu.cas.cz/en/research/laboratory-of-antibiotic-resistance-and-microbial-metabolomics"><strong>Laboratory of Antibiotic Resistance and Microbial Metabolomics</strong></a><strong>, and what project are you currently working on?</strong></h5><p>I came to the Institute of Microbiology through a&nbsp;joint project between<strong> Dr Zdeněk Kameník and Assoc. Prof. Jan Bobek from the First Faculty of Medicine, Charles University</strong>. For me, it was also an opportunity to move from targeted analysis and the study of chromatographic techniques towards untargeted metabolomics and new biological questions.</p><p>In the project, we are trying to identify new biologically active compounds that would be effective, particularly against pathogenic fungi. As a&nbsp;potential source of such compounds, we study streptomycetes, bacteria known for their ability to produce a&nbsp;wide range of biologically active compounds, including many antibiotics that are currently in clinical use. We focus on less-explored host-associated streptomycetes, in which we had already observed antifungal activity in previous experiments. We are especially interested in strains active against Candida albicans whose activity cannot be explained by the presence of a&nbsp;known bioactive compound. These strains may represent an interesting source of novel compounds. We then integrate the results of untargeted metabolomic analyses with genomic analyses, which allows us to obtain a&nbsp;more comprehensive view of the biosynthetic potential of selected strains.</p><h5><strong>You also took part in this year’s Vědafest, a&nbsp;science outreach event for the public. What was it like?</strong></h5><p>I already had some experience with science outreach through events such as Researchers’ Night and the Science Fair at my previous institution, but this year’s Vědafest was still new to me in some ways. This time, I&nbsp;was presenting a&nbsp;field that I&nbsp;myself had entered only relatively recently. It was therefore more challenging to find the right analogies and explain the essence of the topic in a&nbsp;way that was simple, yet precise and scientifically accurate. At the same time, that was exactly what made it inspiring. It forces you to look at your own work from a&nbsp;different perspective. What I&nbsp;enjoyed most was the spontaneity and curiosity of the children, who often came up with questions that would never even occur to an adult.</p><h5><strong>What are the biggest challenges you face on your scientific journey, and what helps you overcome them?</strong></h5><p>One of the greatest, but at the same time most interesting, challenges is, in my view, the uncertainty that is inseparably linked to research. For a&nbsp;long time, you often do not know whether you have taken the right direction in addressing a&nbsp;particular question or whether you will ultimately manage to find that figurative final piece of the puzzle. At the same time, this uncertainty is precisely what makes science exciting for me.</p><p>Another major challenge, particularly in interdisciplinary projects, is communication. It is important from the very formulation of a&nbsp;hypothesis and the planning of experiments through to the interpretation of results, including negative ones, and placing them in a&nbsp;broader context. To some extent, every field has its own language, and finding a&nbsp;common understanding is not always straightforward. Personally, I&nbsp;find it very helpful to be able to discuss problems with colleagues on an ongoing basis, whether individually or during regular laboratory seminars. One of the major strengths of our current group is its interdisciplinary nature, which allows me to look at the same problem from several different perspectives. It is also important for me not to lose my curiosity, because that is ultimately what leads us to ask further questions.</p><h5><strong>What are your plans after completing your PhD?</strong></h5><p>After finishing my PhD, I&nbsp;decided that I&nbsp;do not need to have everything that comes next precisely mapped out straight away. I&nbsp;would like to keep different options open for a&nbsp;while and continue building on my experience in analytical chemistry, while at the same time connecting it with other areas that have a&nbsp;biological or medical relevance. I&nbsp;believe that we can keep learning throughout our lives, so I&nbsp;am quite curious to see where the next stage of my journey will take me.</p><p><i>Thank you for the interview!</i></p>

Interview: What Drew Postdoc Taťána Gazárková to Analytical Chemistry

<p><strong>Per- and polyfluoroalkyl substances (PFAS) have earned the moniker "forever chemicals" due to their extreme persistence in the environment. Their detection is crucial for protecting public health and the environment as these synthetic compounds continue to pose significant challenges worldwide. This comprehensive exploration examines why PFAS detection matters, current detection methods, and future directions in addressing PFAS contamination.</strong></p><h3><strong>Understanding PFAS and Their Health Impacts</strong></h3><p>PFAS are a class of synthetic organic compounds with diverse structures, properties, and uses. Despite their diversity, all PFAS contain perfluoroalkyl moieties that are extremely resistant to environmental and metabolic degradation [1]. This high persistence is a defining characteristic that makes PFAS management particularly challenging.</p><h3><strong>Documented Health Effects</strong></h3><p>Current scientific research has linked PFAS exposure to numerous adverse health outcomes:</p><ul><li>Reproductive effects including decreased fertility and increased high blood pressure in pregnant women [8]</li><li>Developmental effects in children such as low birth weight, accelerated puberty, and behavioral changes [8]</li><li>Reduced immune system function, including decreased vaccine response</li><li>Interference with natural hormones and endocrine disruption</li><li>Increased cholesterol levels and obesity risk</li><li>Increased risk of several cancers, including prostate, kidney, testicular, oral cavity/pharynx, brain, and endocrine cancers [3]</li></ul><p>A 2023 study linked PFAS-contaminated water with up to a <strong>33% increase in cancer incidence</strong> in affected areas [3]. The study compared regions with elevated PFAS levels to cancer data from the National Cancer Institute, finding higher incidences of various cancers after controlling for factors like smoking and obesity.</p><h3><strong>Environmental Persistence and Contamination</strong></h3><p>The extreme persistence of PFAS represents a fundamental concern for environmental management. PFAS are considered the most environmentally persistent substances among organic chemicals [7]. This persistence means that even if all PFAS uses were immediately phased out, existing contamination would continue to affect ecosystems and water supplies for generations.</p><p>A 2023 study at a military fire training site estimated that PFAS contamination will persist for centuries without remediation [7]. The research found that terminal PFAS still exceed regulatory limits by 2000-fold decades after aqueous film-forming foam (AFFF) use ceased, with precursors accounting for around half of the extractable organofluorine across years.</p><h3><strong>Current Detection Methods</strong></h3><h4><strong>EPA Standardized Methods</strong></h4><p>The<strong> Environmental Protection Agency (EPA</strong>) has developed several standardized methods for PFAS detection, each with specific applications and capabilities:</p><h5><strong>EPA Method 533</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/epa-533-drying-down-pfas-samples-after-spe"><strong>EPA Method 533</strong></a> focuses on "short chain" PFAS with carbon chain lengths of<strong> C4 to C12</strong>. Released in December 2019, this method complements Method 537.1 and includes several key features:</p><ul><li>Uses isotope dilution quantification approach with extracted internal standards, which reduces overall analytical uncertainty</li><li>Employs weak anion exchange solid phase extraction cartridges as opposed to polystyrene divinylbenzene used in 537.1</li><li>Can analyze 25 PFAS compounds, including additional short-chain PFAS that were not apart of Method 537.1</li><li>Allows for longer holding times: 28 days to extraction and 28 days to analyze (compared to 14 days to extraction in Method 537.1)</li><li>Uses ammonium acetate as a preservative (versus Trisma in Method 537.1) [1]</li></ul><h5><strong>EPA Method 537/537.1</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/sample-concentration-epa-method-537-pfas-determination"><strong>EPA Method 537 </strong></a>was first published in 2009 for the determination of 14 PFAS in drinking water [6]. It was later updated to Method 537.1 in 2018 (with editorial updates in 2020) to expand its capabilities:</p><ul><li>Uses<a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/what-is-solid-phase-extraction-spe"><strong> solid phase extraction (SPE) </strong></a>and<a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/preparing-samples-for-lc-ms/ms-analysis"><strong> liquid chromatography/tandem mass spectrometry (LC-MS/MS)</strong></a></li><li>Method 537.1 expanded detection to 18 PFAS compounds, including HFPO-DA (one component of GenX technology)</li><li>Utilizes styrene-divinylbenzene (SDVB) media for extraction</li><li>Requires samples to be extracted within 14 days and analyzed within 28 days</li><li>Methanol is used to elute the extracts. This should then be reconstituted with a 96:4 methanol:water mixture [1]</li></ul><p>Together, Methods 533 and 537.1 can detect a total of <strong>29 unique PFAS compounds in drinking water </strong>and are approved for monitoring under the fifth Unregulated Contaminant Monitoring Rule (UCMR 5) and the PFAS National Primary Drinking Water Regulation [1] [3].</p><h5><strong>EPA Method 1633</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/preparing-diverse-sample-matrices-for-epa-method-1633"><strong>EPA Method 1633</strong></a>, released in 2024, represents a significant advancement in PFAS analysis:</p><ul><li>Developed for the analysis of <strong>40 PFAS compounds </strong>in various matrices, including surface water, groundwater, wastewater, soil, biosolids, sediment, landfill leachate, and fish tissue</li><li>Expands beyond the drinking water focus of Methods 533 and 537.1</li><li>Provides a standardized approach that may replace modified drinking water methods (i.e., modified EPA 537) that were previously used for non-drinking water matrices [1]</li></ul><h4><strong>Conventional Analytical Techniques</strong></h4><p>The gold standard for PFAS analysis involves chromatographic techniques coupled with mass spectrometry:</p><ul><li>Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) is the most widely used method for PFAS analysis, offering high sensitivity and specificity [1]</li><li>High-Resolution Mass Spectrometry (HRMS) allows for rapid detection and identification of PFAS species at very low concentrations [5]</li></ul><p>These techniques can detect PFAS at parts per trillion (ppt) levels, which is essential given the low concentrations at which PFAS can cause health effects [1]. However, these methods require sophisticated equipment, specialized training, and significant financial resources, making them inaccessible in many regions, particularly in developing countries.</p><h4><strong>Emerging Detection Technologies</strong></h4><p>Several innovative approaches are being developed to address the limitations of conventional methods:</p><ul><li>Electrochemical biosensors using modified electrodes have shown promise for selective PFAS detection with low detection limits [2]</li><li>Surface-Enhanced Raman Spectroscopy (SERS) uses metallic nanoparticles and can be made into a portable method for on-site testing [1]</li><li>Molecular imprinted polymers (MIPs) offer thermal and physical stability, reusability, and low-cost synthesis for PFAS detection [6]</li></ul><p>These emerging technologies aim to provide more accessible, field-deployable, and cost-effective alternatives to traditional laboratory-based methods.</p><h3><strong>Challenges in PFAS Detection</strong></h3><h4><strong>Analytical Challenges</strong></h4><p>Detecting PFAS presents several technical challenges:</p><ul><li>The ubiquity of PFAS in laboratory equipment and accessories can lead to background contamination when measuring at parts-per-trillion levels [1]</li><li>Many components in liquid chromatographs, mass spectrometers, and solid-phase extraction systems contain materials that can leach PFAS compounds [9]</li><li>The vast number of PFAS (thousands of compounds) makes comprehensive detection difficult, as analytical standards are only available for a small subset [1]</li><li>Complex matrices like food and environmental samples require sophisticated sample preparation techniques</li></ul><h4><strong>Global Disparities in Detection Capabilities</strong></h4><p>Access to PFAS detection technology varies significantly worldwide:</p><ul><li>Many developing regions, particularly in Africa, lack adequately equipped laboratories with the necessary instrumentation to detect and measure PFAS</li><li>There is often a scarcity of qualified professionals with experience in PFAS analysis in these regions</li><li>The high cost of acquiring and maintaining sophisticated analytical instruments presents a substantial obstacle to conducting extensive PFAS investigations in resource-limited settings [1]</li><li>Competing priorities such as infectious diseases, poverty, and food security often divert attention and resources from environmental pollutants like PFAS</li></ul><h4><strong>Regulatory Landscape and Compliance</strong></h4><p>The regulatory framework for PFAS is evolving rapidly worldwide:</p><ul><li>The EPA finalized Section 8(a)(7) of the Toxic Substances Control Act in September 2024, requiring manufacturers and importers to report on their use of PFAS since 2011 [10]</li><li>Electronic reporting for PFAS will open on July 11, 2025, with final reporting deadlines in 2026</li><li>Companies must report detailed information including chemical identity, production volumes, industrial and consumer products, worker exposure, and disposal methods [10]</li></ul><p>These regulations are driving demand for more effective and accessible PFAS detection methods to ensure compliance and protect public health.</p><h3><strong>Future Directions in PFAS Detection</strong></h3><h4><strong>Technological Advancements</strong></h4><p>The future of PFAS detection lies in developing more accessible, sensitive, and comprehensive methods:</p><ul><li>Non-targeted screening methods that can identify unknown PFAS compounds without requiring analytical standards for each specific compound</li><li>Total fluorine analysis techniques like Adsorbable Organic Fluorine and Total Oxidizable Precursor Assay that can quantify the presence of fluorine atoms within a sample [1]</li><li>Portable sensors and field-deployable technologies that enable on-site monitoring and rapid response to contamination events</li><li>AI-driven solutions that can improve data analysis and interpretation for complex PFAS mixtures</li></ul><h4><strong>Collaborative Approaches</strong></h4><p>Addressing the global challenge of PFAS detection requires coordinated efforts:</p><ul><li>International partnerships between researchers in developed and developing regions to enhance expertise and capacity building</li><li>Standardization of analytical methods to ensure consistency and comparability of results across different laboratories and regions</li><li>Open data sharing and collaboration across countries to leverage collective knowledge and resources</li><li>Integration of PFAS monitoring into broader environmental and public health surveillance systems</li></ul><h3><strong>Conclusion</strong></h3><p>The detection of PFAS is not merely a technical challenge but a critical public health and environmental imperative [1]. As these "forever chemicals" continue to persist in our environment, developing effective, accessible, and comprehensive detection methods becomes increasingly important. By advancing detection technologies, strengthening regulatory frameworks, and fostering global collaboration, we can better understand, monitor, and ultimately mitigate the impacts of PFAS contamination.</p><p>The EPA's standardized methods (533, 537.1, and 1633) provide crucial tools for monitoring PFAS in various environmental matrices, but continued innovation is needed to address the full spectrum of PFAS compounds and to make detection more accessible globally [1] [6]. The path forward requires sustained investment in research and development, capacity building in resource-limited settings, and a commitment to environmental justice that ensures all communities have access to the tools and information needed to protect themselves from PFAS exposure. Only through such comprehensive approaches can we hope to address the complex challenges posed by these persistent pollutants.</p><p><span>Be sure to check out our other installments of our&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/introducing-our-environmental-contaminants-series-making-sense-of-the-alphabet-soup"><span>Environmental Contaminant Series</span></a><span>&nbsp;covering&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-persistent-organic-pollutants-pops"><span>Persistent Organic Pollutants (POPs)</span></a><span>,&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-polycyclic-aromatic-hydrocarbons-pahs"><span>Polycyclic Aromatic Hydrocarbons (PAHs)</span></a><span>,&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-semi-volatile-organic-compounds-svocs"><span>Semi-Volatile Organic Compounds (SVOCs)</span></a><span>, and </span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-polychlorinated-biphenyls-pcbs"><span>Polychlorinated Biphenyls (PCBs)</span></a><span>.</span></p>

The Importance of Detecting Per- and Polyfluoroalkyl Substances (PFAS)

News from LabRulezLCMS Library - Week 36, 2026

Article

Application

Scientists

Environment

Water

Interview

The Czech Academy of Sciences (CAS) was established by Act No. 283/1992 Coll. as the Czech successor of the former Czechoslovak Academy of Sciences. It is set up as a complex of 54 public research institutions.

Czech Academy of Sciences

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Separation Science

Agilent Technologies

Technology Networks

Unchained Labs

Phenomenex

Thermo Fisher Scientific

SCIEX

Evosep Biosystems

Waters Corporation

<p><strong>Unexpected changes to our chromatography often lead us to suspect the column first. &nbsp; But, in many cases, the true source of the problem is somewhere else in the system. &nbsp;In this webinar, we’ll explore some of the common chromatography issues we most often hear about as technical support specialists. Whether you’re dealing with shifts in retention time, pressure fluctuations, unexpected peaks, ghost peaks, missing peaks, or your peak shapes just don’t look right, we’ll walk through practical steps for diagnosing and resolving the problem. Having an understanding for where issues typically occur can help us to quickly identify the problem, implement the right corrective action, and prevent the problem from recurring in the future.</strong></p><blockquote><p><strong>Speaker:</strong> Jean Lane (Application Engineer, Agilent Technologies, Inc.)</p><p>Jean has been employed with Agilent since Nov 2010 in technical and applications support and has a primary role supporting Agilent’s full line of LC columns and consumables, which also includes support for Agilent’s GPC/SEC product line. She came to Agilent thru acquisition of Varian and the former Polymer Laboratories. Jean has 20 plus years of technical and applications support for both HPLC and GPC consumable products. In addition to practical chromatography experience in the laboratory, she has had many, many years in her technical role involving customer support providing assistance and troubleshooting for customer chromatography issues.</p></blockquote>

Agilent Technologies: Becoming A Better Chromatographer Webinar Series

Why Your Column Isn’t Always the Culprit: Smarter HPLC Troubleshooting

Master HPLC troubleshooting with Agilent. Learn to diagnose retention shifts, pressure issues, and ghost peaks outside of the column environment

Smarter HPLC Troubleshooting: Beyond the Column Issues

<h4><strong>What’s trending across Asia and what you should know next</strong></h4><p><strong>PFAS Asia Summit is back in 2026! Join us with leading experts across science and industry to explore the latest PFAS developments shaping Asia. From evolving regulatory frameworks to cutting-edge research and analytical innovation, this summit offers a focused platform to understand emerging risks, industry responses - helping you stay informed and prepared in a rapidly changing PFAS landscape.</strong></p><h4><strong>What you will learn:</strong></h4><ul><li>Latest PFAS regulatory updates across global and Asian markets</li><li>Emerging PFAS trends in key industries, including agriculture, electronics, and pharmaceuticals</li><li>Advances in sample preparation and integrated LC-MS/MS technologies for PFAS detection and analysis</li></ul><h4><strong>Agenda</strong></h4><h5><strong>09:00 - 09:05 a.m. Welcome &amp; Introduction</strong></h5><h5><strong>09:05 - 09:35 a.m. PFAS around the world - Regulatory and analytical trends</strong></h5><ul><li>Holly Lee (SCIEX)</li></ul><h5><strong>09:35 - 10:05 a.m. Utilizing LC-MS for proactive PFAS detection in Pharma</strong></h5><ul><li>Eshani Galermo (SCIEX)</li></ul><h5><strong>10:05 - 10:35 a.m. Advanced strategies in LC-MS/MS for clean-up and analysis of PFAS compounds in various sample matrices</strong></h5><ul><li>Namrata Saxena (Phenomenex)</li></ul><h5><strong>10:35 - 11:00 a.m. Behavior and metabolic effects of PFAS in wheat</strong></h5><ul><li>Yanwei Zhang (China)<ul><li><i>*Speaking language: Chinese</i></li></ul></li></ul><h5><strong>11:00 - 11:25 a.m. Standardization of IEC test methods for PFAS regulation compliance in the electrical, electronics, and automotive plastic industries</strong></h5><ul><li>Jaehak Jung (Korea)<ul><li><i>*Speaking language: Korean</i></li></ul></li></ul><h5><strong>11:25 - 11:55 a.m. Nontarget screening of PFAS transformation products during photoelectrochemical degradation of PFAS in water</strong></h5><ul><li>Jheng-Sian, Yang (Taiwan)<ul><li><i>*Speaking language: Chinese</i></li></ul></li></ul><h5><strong>11:55 a.m. - 12:10 p.m. Q&amp;A</strong></h5><p><i>*Sessions delivered in non-English languages will be supported with English subtitles.</i></p><blockquote><p><strong>Speaker: </strong>Yanwei Zhang, Ph.D. (Associate Researcher, Agro-Environmental Protection Institute, Ministry of Agriculture and Rural Affairs, China)</p><p><strong>Speaker:</strong>&nbsp;Jaehak Jung, Ph.D. (Chief Technology Officer (CTO), Korea Institute of Analytical Science and Technology (KAIST), Republic of Korea)</p><p><strong>Speaker:</strong> Jheng-Sian Yang, Ph.D. (Assistant Professor, Department of Safety, Health and Environmental Engineering, National United University, Taiwan)</p><p><strong>Speaker:</strong> Holly Lee (Staff Scientist, Global Technical Marketing, Food, SCIEX)</p><p><strong>Speaker:</strong> Eshani Galermo (Staff Scientist, Pharma/Biopharma Quant Lead, SCIEX)</p><p><strong>Speaker:</strong> Namrata Saxena (Technical Manager, Asia/Pacific, Phenomenex)</p><p><strong>Speaker:</strong> See Chung Yip (Field Application Manager, SCIEX)</p></blockquote>

PFAS Asia Summit 2026

Stay ahead of the changing PFAS landscape in Asia. Learn about evolving regulations, industry impacts, and cutting-edge LC-MS/MS analytical methods

PFAS Asia Summit 2026: Trends, Regulations & LC-MS/MS  

<div><h4><strong>Minimizing QC Release Risk Through Molecule‑Specific Analytics in Empower™ CDS</strong></h4><p><strong>As MALS gains adoption in QC, many biopharmaceutical labs face a disconnect between absolute molecular measurements and confident lot‑release decisions. Reliance on relative SEC methods, manual calculations, and subjective interpretation can obscure risks related to aggregation, recovery, and molecular distribution - often emerging only during method transfer or regulatory review.</strong></p><p>In this webinar, we show how integrating QC‑ready MALS into an Empower™ workflow enables labs to quantify and manage release risk. Standardized calculations convert raw MALS data into objective, reviewable metrics - reducing analyst‑dependent interpretation and supporting defensible release decisions before risks become compliance issues.</p><h4><strong>What will you learn?</strong></h4><ul><li>Transition MALS from characterization to routine QC testing</li><li>Automate critical molecular metrics tied to release specifications</li><li>Improve consistency, traceability, and confidence in release decisions</li></ul><h4><strong>Who should attend</strong></h4><ul><li>QC Managers and Directors responsible for release testing</li><li>MSAT and Method Transfer teams moving methods into QC</li><li>Analytical Development scientists supporting late stage programs</li><li>Regulatory Affairs and Compliance professionals focused on audit readiness</li><li>Organizations working with proteins, peptides, biologics, or complex modalities where aggregation and heterogeneity impact release decisions</li></ul><blockquote><p><strong>Presenter:</strong> Colette Quinn, Ph.D. (Light Scattering Portfolio Owner, Waters Corporation)</p><p>Colette Quinn is a Sr. business development manager in the biopharmaceutical group at Waters Corporation. Her focus is around biophysical solutions and how to integrate biophysical and biochemical approaches to enable a “totality of evidence” based approach to problems.</p></blockquote><blockquote><p><strong>Presenter:</strong> Neil Lander (Senior Principal Product Manager, Waters Corporation)</p><p>Neil has worked for Waters Corporation since 1994 and has held a variety of positions including Technical Support Specialist, Technical Trainer, Manager Customer Education and currently, Senior Principal Product Manager focusing on Informatics solutions.</p><p>He provides internal support for Empower Chromatography Data System and is focused on developing laboratory software solutions that help organizations achieve their scientific and operational objectives.</p></blockquote></div>

Waters Corporation: Reduce QC Release Risk with Molecule Specific Analytics: QC Ready MALS in Empower™ CDS

Reduce QC Release Risk with Molecule Specific Analytics: QC Ready MALS in Empower™ CDS

Reduce biopharma release risks by integrating MALS into Empower CDS. Automate molecular metrics, eliminate manual math, and secure audit readiness

Reduce QC Release Risk with Empower Integrated MALS

<p><strong>Deep visual proteomics and quantitative proteomic assays are expanding the possibilities for understanding disease biology and translating discoveries into actionable insights. By combining spatially resolved proteomics with robust quantitative workflows, researchers can gain a more comprehensive view of complex biological systems.</strong></p><p>In this webinar, our speakers will share perspectives on the application of deep visual proteomics and quantitative assays in translational and biomedical research. Join us to learn how advanced proteomic workflows can help uncover biologically relevant targets, improve analytical confidence, and support the generation of high-quality data at scale.</p><h5><strong>Precision at the Microscale: Low Input Spatial Proteomics in the 5xFAD Brain</strong></h5><ul><li>T. Wolf, Post Doc, Drug Safety R&amp;D, Pfizer</li></ul><p>Using the <strong>Evosep Eno and Orbitrap Astral Zoom</strong>, we applied a spatial proteomics workflow integrating AI-driven image segmentation with low-input mass spectrometry. This high-resolution pipeline reliably captured 5xFAD brain microenvironments, resolving distinct local proteomes to reveal diverging pathological pathways between plaques and microglial subtypes.</p><h5><strong>Reimagining Large Molecule PK Analysis with High-Throughput Evosep ENO LCMS</strong></h5><ul><li>Rebecca Ferreira, Senior Associate Scientist, Pfizer</li></ul><p>Accelerate biologics discovery with high-throughput LCMS. Learn how the Neubert Group at Pfizer is using the<strong> Evosep ENO</strong> platform to improve PK assay throughput while maintaining sensitivity and robustness needed for surrogate peptide quantification, enabling faster construct selection and optimization.</p>

Evosep: Perspective from Industry - Deep Visual Proteomics and Quantitative Assays

Perspective from Industry: Deep Visual Proteomics and Quantitative Assays

Advance translational research with Evosep. Discover how deep visual proteomics and scalable quantitative assays improve target discovery and confidence

Deep Visual Proteomics and Quantitative Assays

<div><p><strong>Per- and polyfluoroalkyl substances (PFAS) are a diverse class of persistent environmental contaminants that can accumulate in biological systems and pose potential risks to human and environmental health. Understanding how different PFAS structures behave within living organisms, including the distribution of individual isomers and their biological effects, remains a significant analytical challenge.</strong></p><p>In this webinar, researchers will demonstrate how matrix-assisted laser desorption/ionization trapped ion mobility spectrometry mass spectrometry was used to differentiate PFAS isomers, analyze PFAS-exposed bacterial biomass, and investigate tissue-specific PFAS distribution in a mouse model.</p><p>The session will also explore PFAS-associated changes to the hepatic lipidome, highlighting the potential of advanced mass spectrometry approaches for PFAS research.</p><h4><strong>Attend this webinar to:</strong></h4><ul><li>Understand advanced mass spectrometry approaches for PFAS detection, characterization, and isomer differentiation</li><li>Learn how spatial imaging techniques reveal the biological impact and tissue distribution of environmental contaminants</li><li>Explore emerging applications of spatial mass spectrometry for studying microplastics and other environmental pollutants</li></ul><blockquote><p><strong>Presenter:</strong> &nbsp;Elizabeth Neumann, PhD &nbsp;( Assistant Professor, University of California, Davis)</p><p>&nbsp;Elizabeth Neumann is an assistant professor in the chemistry department at UC Davis. Her research focuses on understanding the molecular and cellular architecture behind complex human disorders, such as renal cell carcinoma, spina bifida and Alzheimer's Disease.&nbsp;</p></blockquote><blockquote><p><strong>Presenter: </strong>Autumn Qiu, PhD ( Assistant Professor, Michigan State University)</p><p>&nbsp;Prof. Tian (Autumn) Qiu earned her Bachelor of Science in chemistry from Peking University and her PhD from the University of Minnesota. Autumn’s PhD studies focused on nanotoxicity mechanisms in environmental bacteria at the Center for Sustainable Nanotechnology. She was a Beckman Postdoctoral Fellow at the University of Illinois at Urbana-Champaign and worked on D-amino acids in the microbiome-gut-brain axis. She joined Michigan State University as an Assistant Professor in 2022. Her lab investigates interactions among environmental contaminants, microbial metabolism, and host responses using mass spectrometry, particularly MALDI-MS, integrated with animal models and toxicological analyses.&nbsp;</p></blockquote></div>

Bruker: Unlocking New Insights Into PFAS Distribution and Biological Impact

Unlocking New Insights Into PFAS Distribution and Biological Impact

Explore advanced PFAS analysis with MALDI-TIMS-MS imaging. Discover how to differentiate isomers and investigate tissue-specific lipidome changes

Spatial PFAS Analysis: MALDI-TIMS-MS

<h4><strong>By attending this presentation you will:</strong></h4><ul><li>Explore a range of chromatographic separation modes for Bicycle® molecules and their impurities.</li><li>Gain practical insights into the identification and characterization of impurities and degradation products.</li><li>Learn a systematic approach to developing effective separation methods.</li><li>Recognize best practices for optimizing separations to support analytical development and stability studies.</li></ul><h4><strong>Event Overview</strong></h4><p>Bicycle® molecules are novel medium molecules and provide a unique set of challenges to separate and identify impurities and degradants. They are fully synthetic, short peptides that loop together into two constrained rings. This unique bicyclic shape allows them to mimic the target-binding capabilities of large antibodies while retaining the rapid tissue penetration and manufacturing advantages of small molecules.</p><p>The presentation covers a broad approach to achieving separation with Bicycle® molecules and will touch on a large range of separation modes.</p><blockquote><p><strong>Speaker: </strong>Andrew Feilden (Senior Director, Analytical Sciences, Bicycle Therapeutics)</p><p>Dr Feilden joined Bicycle in October 2022 where he leads the CMC analytical science team. &nbsp;He has over 25 years' experience in the pharmaceutical industry having worked for both CROs and large pharma. &nbsp;His area of work has been around trace analysis and he is an expert in extractables and leachables. &nbsp;He completed his degree and DPhil at the University of York.</p></blockquote>

Agilent Technologies: Analysis of Bicycle® Molecules - Novel Medium Molecules

Analysis of Bicycle® Molecules: Novel Medium Molecules

Explore chromatographic separation modes for Bicycle® peptides. Learn systematic method development to analyze impurities and degradants

Analyzing Bicycle® Molecules: Separation & Impurities

<h4><strong>Key Learning Points</strong></h4><ul><li>Understand how to improve resolution with different stationary phases and mobile phase selectivity.&nbsp;</li><li>Learn key method development strategies for unknowns and complex mixtures.</li><li>Build LC methods that are reproducible, rugged, and transferable.</li><li>Review real examples of how to separate difficult compound classes.</li></ul><h4><strong>Who Should Attend</strong></h4><ul><li>Any LC users who want practical strategies for method development and optimization, or scientists who struggle with method reproducibility, ruggedness, or robustness.</li></ul><h4><strong>One webinar, two viewing options</strong></h4><p>We know you're busy, select a viewing session that works best for you.</p><h5><strong>Viewing Options</strong></h5><p><strong>Session 1</strong></p><ul><li><strong>Tuesday, August 11, 2026</strong></li><li>Los Angeles: 10:00 AM PT | New York: 1:00 PM EST</li><li>Mexico City: 12:00 PM CDT</li></ul><p><strong>Session 2</strong></p><ul><li><strong>Wednesday, &nbsp;August 12, 2026</strong></li><li>London: 9:00 AM BST | Berlin: 10:00 AM CEST&nbsp;</li><li>Mumbai: 1:30 PM IST</li></ul><blockquote><p><strong>Speaker:</strong> Grace Guo (Senior Technical Specialist, Phenomenex)</p><p>&nbsp;Grace Guo graduated from Johns Hopkins University with a Master’s degree in Material Science and Engineering. She joined Phenomenex Technical Team in 2017 providing technical support globally. With more than 9 years of experience in SPE, HPLC and GC, she delivered 90+ seminars and webinars globally covering food and environmental, clinical, pharma and biopharma industry.&nbsp;</p></blockquote>

Phenomenex: Unknowns Uncovered - Smart LC Strategies That Work

Unknowns Uncovered: Smart LC Strategies That Work

Master smart LC method development for unknown compounds. Learn Phenomenex strategies for better resolution, stationary phase selectivity, and ruggedness

Smart LC Strategies That Work

<p><strong>Therapeutic peptides are a fast-growing pharmaceutical drug class, but they present unique analytical challenges due to closely related process impurities, degradation products, and higher-order aggregate species. This webinar shows how complementary chromatographic workflows can be used to address those challenges, with examples spanning assay, related substances, stability-indicating analysis, and aggregate assessment. Real-world applications will cover aggregation profiles of key GLP-1 receptor agonists, including semaglutide, liraglutide, and tirzepatide.</strong></p><h4><strong>Key Learning Points</strong></h4><ul><li>Understand the main analytical challenges involved in therapeutic peptide characterization, including closely related impurities, degradation products, and aggregate species.</li><li>Describe where reversed-phase chromatography and size exclusion chromatography fit across therapeutic peptide development workflows.&nbsp;</li><li>Learn how different reversed-phase selectivities were used for semaglutide assay, related substances, and stability/degradant studies, and understand how similar workflows can be adapted for other GLP-1 analogs, including tirzepatide.</li></ul><h4><strong>Who Should Attend</strong></h4><ul><li>Any liquid chromatography users working with, or interested in analyzing peptide therapeutics by HPLC. &nbsp;</li></ul><blockquote><p><strong>Speaker:</strong> Sean Orlowicz (Principal Market Development Manager, Phenomenex)</p><p>Sean Orlowicz has been working in the field of analytical chemistry for over 23yrs. After receiving his degree in Chemistry from the University of Illinois at Chicago, he started his career in large scale synthesis, using HPLC and GC techniques in reaction monitoring and purification. Sean took this experience to Phenomenex in 2003, working on site with clients worldwide on method development, troubleshooting and method transfer. Sean explored instrumentation for a few years, growing to specialize in LCMS, before returning to Phenomenex to help build and manage Phenomenex’s new applications laboratory. Since then, Sean has been driving innovation and growth though Business Development efforts, and most recently, in 2025 Sean has taken a Market Development Management role, spearheading our global efforts in Pharmaceuticals.&nbsp;</p></blockquote>

GLP-1: Assay to Aggregates

Master GLP-1 peptide analysis (semaglutide, tirzepatide). Discover RP-HPLC and SEC workflows for assay, related substances, degradation, and aggregates

GLP-1 Peptide Characterization: RP-HPLC & SEC Workflows

<h5><strong>The Problem&nbsp;</strong></h5><p>Most researchers developing LNPs are stuck in the shade with one-by-one LNP makers that either run costly single use consumables or need a whole extra run to clean the mixer and flowpath before pressing on with more formulations. They tie researchers to the lab bench, and often consume more reagents than you’d ideally want. At the end of the day, this means fewer samples processed, with more hands-on time and higher per experiment costs&nbsp;</p><h5><strong>The Solution</strong></h5><p>Sunscreen stops formulation labs from getting burnt by high costs, wasted reagents and laborious sample processing with 100% re-usable mixers and automated sample processing in a 96 well plate format. Using as little as 400 µL of sample per formulation and running a sample every 3-4 minutes, you get more formulations in less time from less material – all while you bask in the extra hours you thought you’d never get back.&nbsp;</p><h5><strong>The Proof&nbsp;</strong></h5><p>In this virtual seminar we’ll shed light on how Sunscreen’s automation enables fully hands-free LNP formulation, learn about the benefits of mixing LNPs with Sunnies, and check out the impact of Sunscreen vs one-by-one approaches.&nbsp;</p><blockquote><p><strong>Presenter: </strong>Ben Knappett, PhD (Sr. Product Manager, The Sunny Suite, Unchained Labs)</p><p>Ben Knappett is the Sr. Product Manager for the Sunny Suite, Unchained Labs’ automated microfluidic nanoparticle synthesis instruments, used primarily for LNP encapsulation in drug delivery, vaccines, and gene therapy applications. Ben received his MChem degree from Durham University, and completed a PhD in nanoparticle synthesis and characterization at the University of Cambridge. Ben previously worked for Particle Works as Head of Science and Applications, playing a key role in the development and commercialization of the instruments that now make up the Sunny Suite.</p></blockquote>

Unchained Labs: Make your LNP formulation workflow shine with Sunscreen

Make your LNP formulation workflow shine with Sunscreen

Automate LNP formulation with the Sunscreen system. Learn how 96-well plate automation and reusable mixers reduce reagent waste and speed up workflows.

Automated LNP Formulation Workflows: Sunscreen Platform

<div><div id="inner_content_body_text" data-content-id="394785"><p><strong>As PFAS regulations continue to evolve, laboratories face increasing pressure to detect a broader range of compounds while maintaining confidence, efficiency, and regulatory readiness. Traditional targeted methods remain essential, but growing awareness of emerging PFAS is driving the need for more comprehensive analytical strategies.</strong></p><p><strong>Join us for a webinar exploring the latest advances in high-resolution mass spectrometry and intelligent data analysis that enable more comprehensive PFAS characterization in food and food-contact material testing.</strong></p><h4><strong>You will learn how to:</strong></h4><ul><li>Expand PFAS detection beyond targeted analysis</li><li>Improve confidence in identifying known and emerging PFAS</li><li>Streamline PFAS identification with intelligent data analysis workflows</li><li>Stay ahead of evolving food safety testing requirements</li></ul><p>The webinar concludes with a <strong>live panel discussion</strong> moderated by <strong>Dr. Dasharath P. Oulkar </strong>(Thermo Fisher Scientific). Joined by invited customer speakers, the panel will explore the growing focus on <strong>PFAS in seafood, </strong>discussing current analytical challenges, regulatory considerations, and practical approaches to testing.</p><p>English subtitles will be provided for this webinar and a Certificate of Attendance will be awarded to all attendees of the live webcast.</p><blockquote><p><strong>Presenter:</strong> Jeremy Koelmel, Ph.D. (Associate Research Scientist in Epidemiology, Yale University)</p></blockquote><blockquote><p><strong>Panel Discussion:</strong> Dasharath P. Oulkar, Ph.D. (Manager, FSSAI-Thermo Fisher Scientific Food Safety Solution Center, Ghaziabad, Thermo Fisher Scientific, India)</p><p>Dr Dasharath P. Oulkar has 20+ years of experience in the area of food safety and quality testing and extensive technical experience various chromatography, mass spectrometry and sample preparation techniques required for food safety, authenticity and quality. He is currently working in collaboration with FSSAI to develop new methods and supporting various food laboratories across APJ.&nbsp;</p></blockquote></div></div>

Thermo Fisher Scientific: Future-Proofing Emerging Contaminants in Food Analysis

Future-Proofing Emerging Contaminants in Food Analysis

Future-proof your food testing lab against evolving PFAS regulations. Learn how high-resolution MS and intelligent workflows identify emerging contaminants