<p><strong>Taťána Gazárková is currently a&nbsp;postdoctoral fellow in the Laboratory of Antibiotic Resistance and Microbial Metabolomics. During her doctoral studies, she focused on chromatography and mass spectrometry. Recently, she was awarded second place in the “Sanofi Prize for Pharmacy 2026” competition.</strong></p><p><strong>Taťána Gazárková </strong>is currently a&nbsp;postdoctoral fellow in the <strong>Laboratory of Antibiotic Resistance and Microbial Metabolomics</strong>. During her doctoral studies, she focused on chromatography and mass spectrometry. Recently, she was awarded second place in the <strong>“Sanofi Prize for Pharmacy 2026” </strong>competition, which is awarded by the<strong> French Embassy in the Czech Republic</strong> for her dissertation – Steroid Analysis Using Modern Chromatographic and Mass Spectrometry Techniques: From Fundamental Studies to Targeted Bioanalytical Applications (supervisor: <strong>Lucie Nováková, Charles University</strong>).&nbsp;</p><h5><strong>What makes this field particularly exciting or unique in your view?</strong></h5><p>What I&nbsp;enjoy about analytical chemistry is that, to a&nbsp;certain extent, it is a&nbsp;kind of detective work. You are often looking for ways to “make the invisible visible”. In other words, extract the information you are interested in from a&nbsp;complex sample and then interpret it correctly. What also appeals to me about bioanalytical chemistry is its interdisciplinary nature. It brings together analytical chemistry, biochemistry, biology and medicine, which means that you need to be able not only to translate a&nbsp;biological or clinical question into a&nbsp;measurable analytical experiment, but also to place the resulting data back into a&nbsp;broader biological context. This combination of different perspectives is probably what I&nbsp;enjoy most about the field. At the same time, there is still plenty of room for fundamental research, ranging from studying analytical techniques themselves and improving them to developing new methodological approaches.</p><h5><strong>How did you end up at the </strong><a target="_blank" rel="noopener noreferrer" href="https://mbu.cas.cz/en/research/laboratory-of-antibiotic-resistance-and-microbial-metabolomics"><strong>Laboratory of Antibiotic Resistance and Microbial Metabolomics</strong></a><strong>, and what project are you currently working on?</strong></h5><p>I came to the Institute of Microbiology through a&nbsp;joint project between<strong> Dr Zdeněk Kameník and Assoc. Prof. Jan Bobek from the First Faculty of Medicine, Charles University</strong>. For me, it was also an opportunity to move from targeted analysis and the study of chromatographic techniques towards untargeted metabolomics and new biological questions.</p><p>In the project, we are trying to identify new biologically active compounds that would be effective, particularly against pathogenic fungi. As a&nbsp;potential source of such compounds, we study streptomycetes, bacteria known for their ability to produce a&nbsp;wide range of biologically active compounds, including many antibiotics that are currently in clinical use. We focus on less-explored host-associated streptomycetes, in which we had already observed antifungal activity in previous experiments. We are especially interested in strains active against Candida albicans whose activity cannot be explained by the presence of a&nbsp;known bioactive compound. These strains may represent an interesting source of novel compounds. We then integrate the results of untargeted metabolomic analyses with genomic analyses, which allows us to obtain a&nbsp;more comprehensive view of the biosynthetic potential of selected strains.</p><h5><strong>You also took part in this year’s Vědafest, a&nbsp;science outreach event for the public. What was it like?</strong></h5><p>I already had some experience with science outreach through events such as Researchers’ Night and the Science Fair at my previous institution, but this year’s Vědafest was still new to me in some ways. This time, I&nbsp;was presenting a&nbsp;field that I&nbsp;myself had entered only relatively recently. It was therefore more challenging to find the right analogies and explain the essence of the topic in a&nbsp;way that was simple, yet precise and scientifically accurate. At the same time, that was exactly what made it inspiring. It forces you to look at your own work from a&nbsp;different perspective. What I&nbsp;enjoyed most was the spontaneity and curiosity of the children, who often came up with questions that would never even occur to an adult.</p><h5><strong>What are the biggest challenges you face on your scientific journey, and what helps you overcome them?</strong></h5><p>One of the greatest, but at the same time most interesting, challenges is, in my view, the uncertainty that is inseparably linked to research. For a&nbsp;long time, you often do not know whether you have taken the right direction in addressing a&nbsp;particular question or whether you will ultimately manage to find that figurative final piece of the puzzle. At the same time, this uncertainty is precisely what makes science exciting for me.</p><p>Another major challenge, particularly in interdisciplinary projects, is communication. It is important from the very formulation of a&nbsp;hypothesis and the planning of experiments through to the interpretation of results, including negative ones, and placing them in a&nbsp;broader context. To some extent, every field has its own language, and finding a&nbsp;common understanding is not always straightforward. Personally, I&nbsp;find it very helpful to be able to discuss problems with colleagues on an ongoing basis, whether individually or during regular laboratory seminars. One of the major strengths of our current group is its interdisciplinary nature, which allows me to look at the same problem from several different perspectives. It is also important for me not to lose my curiosity, because that is ultimately what leads us to ask further questions.</p><h5><strong>What are your plans after completing your PhD?</strong></h5><p>After finishing my PhD, I&nbsp;decided that I&nbsp;do not need to have everything that comes next precisely mapped out straight away. I&nbsp;would like to keep different options open for a&nbsp;while and continue building on my experience in analytical chemistry, while at the same time connecting it with other areas that have a&nbsp;biological or medical relevance. I&nbsp;believe that we can keep learning throughout our lives, so I&nbsp;am quite curious to see where the next stage of my journey will take me.</p><p><i>Thank you for the interview!</i></p>

Interview: What Drew Postdoc Taťána Gazárková to Analytical Chemistry

<p><strong>Per- and polyfluoroalkyl substances (PFAS) have earned the moniker "forever chemicals" due to their extreme persistence in the environment. Their detection is crucial for protecting public health and the environment as these synthetic compounds continue to pose significant challenges worldwide. This comprehensive exploration examines why PFAS detection matters, current detection methods, and future directions in addressing PFAS contamination.</strong></p><h3><strong>Understanding PFAS and Their Health Impacts</strong></h3><p>PFAS are a class of synthetic organic compounds with diverse structures, properties, and uses. Despite their diversity, all PFAS contain perfluoroalkyl moieties that are extremely resistant to environmental and metabolic degradation [1]. This high persistence is a defining characteristic that makes PFAS management particularly challenging.</p><h3><strong>Documented Health Effects</strong></h3><p>Current scientific research has linked PFAS exposure to numerous adverse health outcomes:</p><ul><li>Reproductive effects including decreased fertility and increased high blood pressure in pregnant women [8]</li><li>Developmental effects in children such as low birth weight, accelerated puberty, and behavioral changes [8]</li><li>Reduced immune system function, including decreased vaccine response</li><li>Interference with natural hormones and endocrine disruption</li><li>Increased cholesterol levels and obesity risk</li><li>Increased risk of several cancers, including prostate, kidney, testicular, oral cavity/pharynx, brain, and endocrine cancers [3]</li></ul><p>A 2023 study linked PFAS-contaminated water with up to a <strong>33% increase in cancer incidence</strong> in affected areas [3]. The study compared regions with elevated PFAS levels to cancer data from the National Cancer Institute, finding higher incidences of various cancers after controlling for factors like smoking and obesity.</p><h3><strong>Environmental Persistence and Contamination</strong></h3><p>The extreme persistence of PFAS represents a fundamental concern for environmental management. PFAS are considered the most environmentally persistent substances among organic chemicals [7]. This persistence means that even if all PFAS uses were immediately phased out, existing contamination would continue to affect ecosystems and water supplies for generations.</p><p>A 2023 study at a military fire training site estimated that PFAS contamination will persist for centuries without remediation [7]. The research found that terminal PFAS still exceed regulatory limits by 2000-fold decades after aqueous film-forming foam (AFFF) use ceased, with precursors accounting for around half of the extractable organofluorine across years.</p><h3><strong>Current Detection Methods</strong></h3><h4><strong>EPA Standardized Methods</strong></h4><p>The<strong> Environmental Protection Agency (EPA</strong>) has developed several standardized methods for PFAS detection, each with specific applications and capabilities:</p><h5><strong>EPA Method 533</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/epa-533-drying-down-pfas-samples-after-spe"><strong>EPA Method 533</strong></a> focuses on "short chain" PFAS with carbon chain lengths of<strong> C4 to C12</strong>. Released in December 2019, this method complements Method 537.1 and includes several key features:</p><ul><li>Uses isotope dilution quantification approach with extracted internal standards, which reduces overall analytical uncertainty</li><li>Employs weak anion exchange solid phase extraction cartridges as opposed to polystyrene divinylbenzene used in 537.1</li><li>Can analyze 25 PFAS compounds, including additional short-chain PFAS that were not apart of Method 537.1</li><li>Allows for longer holding times: 28 days to extraction and 28 days to analyze (compared to 14 days to extraction in Method 537.1)</li><li>Uses ammonium acetate as a preservative (versus Trisma in Method 537.1) [1]</li></ul><h5><strong>EPA Method 537/537.1</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/sample-concentration-epa-method-537-pfas-determination"><strong>EPA Method 537 </strong></a>was first published in 2009 for the determination of 14 PFAS in drinking water [6]. It was later updated to Method 537.1 in 2018 (with editorial updates in 2020) to expand its capabilities:</p><ul><li>Uses<a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/what-is-solid-phase-extraction-spe"><strong> solid phase extraction (SPE) </strong></a>and<a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/preparing-samples-for-lc-ms/ms-analysis"><strong> liquid chromatography/tandem mass spectrometry (LC-MS/MS)</strong></a></li><li>Method 537.1 expanded detection to 18 PFAS compounds, including HFPO-DA (one component of GenX technology)</li><li>Utilizes styrene-divinylbenzene (SDVB) media for extraction</li><li>Requires samples to be extracted within 14 days and analyzed within 28 days</li><li>Methanol is used to elute the extracts. This should then be reconstituted with a 96:4 methanol:water mixture [1]</li></ul><p>Together, Methods 533 and 537.1 can detect a total of <strong>29 unique PFAS compounds in drinking water </strong>and are approved for monitoring under the fifth Unregulated Contaminant Monitoring Rule (UCMR 5) and the PFAS National Primary Drinking Water Regulation [1] [3].</p><h5><strong>EPA Method 1633</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/preparing-diverse-sample-matrices-for-epa-method-1633"><strong>EPA Method 1633</strong></a>, released in 2024, represents a significant advancement in PFAS analysis:</p><ul><li>Developed for the analysis of <strong>40 PFAS compounds </strong>in various matrices, including surface water, groundwater, wastewater, soil, biosolids, sediment, landfill leachate, and fish tissue</li><li>Expands beyond the drinking water focus of Methods 533 and 537.1</li><li>Provides a standardized approach that may replace modified drinking water methods (i.e., modified EPA 537) that were previously used for non-drinking water matrices [1]</li></ul><h4><strong>Conventional Analytical Techniques</strong></h4><p>The gold standard for PFAS analysis involves chromatographic techniques coupled with mass spectrometry:</p><ul><li>Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) is the most widely used method for PFAS analysis, offering high sensitivity and specificity [1]</li><li>High-Resolution Mass Spectrometry (HRMS) allows for rapid detection and identification of PFAS species at very low concentrations [5]</li></ul><p>These techniques can detect PFAS at parts per trillion (ppt) levels, which is essential given the low concentrations at which PFAS can cause health effects [1]. However, these methods require sophisticated equipment, specialized training, and significant financial resources, making them inaccessible in many regions, particularly in developing countries.</p><h4><strong>Emerging Detection Technologies</strong></h4><p>Several innovative approaches are being developed to address the limitations of conventional methods:</p><ul><li>Electrochemical biosensors using modified electrodes have shown promise for selective PFAS detection with low detection limits [2]</li><li>Surface-Enhanced Raman Spectroscopy (SERS) uses metallic nanoparticles and can be made into a portable method for on-site testing [1]</li><li>Molecular imprinted polymers (MIPs) offer thermal and physical stability, reusability, and low-cost synthesis for PFAS detection [6]</li></ul><p>These emerging technologies aim to provide more accessible, field-deployable, and cost-effective alternatives to traditional laboratory-based methods.</p><h3><strong>Challenges in PFAS Detection</strong></h3><h4><strong>Analytical Challenges</strong></h4><p>Detecting PFAS presents several technical challenges:</p><ul><li>The ubiquity of PFAS in laboratory equipment and accessories can lead to background contamination when measuring at parts-per-trillion levels [1]</li><li>Many components in liquid chromatographs, mass spectrometers, and solid-phase extraction systems contain materials that can leach PFAS compounds [9]</li><li>The vast number of PFAS (thousands of compounds) makes comprehensive detection difficult, as analytical standards are only available for a small subset [1]</li><li>Complex matrices like food and environmental samples require sophisticated sample preparation techniques</li></ul><h4><strong>Global Disparities in Detection Capabilities</strong></h4><p>Access to PFAS detection technology varies significantly worldwide:</p><ul><li>Many developing regions, particularly in Africa, lack adequately equipped laboratories with the necessary instrumentation to detect and measure PFAS</li><li>There is often a scarcity of qualified professionals with experience in PFAS analysis in these regions</li><li>The high cost of acquiring and maintaining sophisticated analytical instruments presents a substantial obstacle to conducting extensive PFAS investigations in resource-limited settings [1]</li><li>Competing priorities such as infectious diseases, poverty, and food security often divert attention and resources from environmental pollutants like PFAS</li></ul><h4><strong>Regulatory Landscape and Compliance</strong></h4><p>The regulatory framework for PFAS is evolving rapidly worldwide:</p><ul><li>The EPA finalized Section 8(a)(7) of the Toxic Substances Control Act in September 2024, requiring manufacturers and importers to report on their use of PFAS since 2011 [10]</li><li>Electronic reporting for PFAS will open on July 11, 2025, with final reporting deadlines in 2026</li><li>Companies must report detailed information including chemical identity, production volumes, industrial and consumer products, worker exposure, and disposal methods [10]</li></ul><p>These regulations are driving demand for more effective and accessible PFAS detection methods to ensure compliance and protect public health.</p><h3><strong>Future Directions in PFAS Detection</strong></h3><h4><strong>Technological Advancements</strong></h4><p>The future of PFAS detection lies in developing more accessible, sensitive, and comprehensive methods:</p><ul><li>Non-targeted screening methods that can identify unknown PFAS compounds without requiring analytical standards for each specific compound</li><li>Total fluorine analysis techniques like Adsorbable Organic Fluorine and Total Oxidizable Precursor Assay that can quantify the presence of fluorine atoms within a sample [1]</li><li>Portable sensors and field-deployable technologies that enable on-site monitoring and rapid response to contamination events</li><li>AI-driven solutions that can improve data analysis and interpretation for complex PFAS mixtures</li></ul><h4><strong>Collaborative Approaches</strong></h4><p>Addressing the global challenge of PFAS detection requires coordinated efforts:</p><ul><li>International partnerships between researchers in developed and developing regions to enhance expertise and capacity building</li><li>Standardization of analytical methods to ensure consistency and comparability of results across different laboratories and regions</li><li>Open data sharing and collaboration across countries to leverage collective knowledge and resources</li><li>Integration of PFAS monitoring into broader environmental and public health surveillance systems</li></ul><h3><strong>Conclusion</strong></h3><p>The detection of PFAS is not merely a technical challenge but a critical public health and environmental imperative [1]. As these "forever chemicals" continue to persist in our environment, developing effective, accessible, and comprehensive detection methods becomes increasingly important. By advancing detection technologies, strengthening regulatory frameworks, and fostering global collaboration, we can better understand, monitor, and ultimately mitigate the impacts of PFAS contamination.</p><p>The EPA's standardized methods (533, 537.1, and 1633) provide crucial tools for monitoring PFAS in various environmental matrices, but continued innovation is needed to address the full spectrum of PFAS compounds and to make detection more accessible globally [1] [6]. The path forward requires sustained investment in research and development, capacity building in resource-limited settings, and a commitment to environmental justice that ensures all communities have access to the tools and information needed to protect themselves from PFAS exposure. Only through such comprehensive approaches can we hope to address the complex challenges posed by these persistent pollutants.</p><p><span>Be sure to check out our other installments of our&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/introducing-our-environmental-contaminants-series-making-sense-of-the-alphabet-soup"><span>Environmental Contaminant Series</span></a><span>&nbsp;covering&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-persistent-organic-pollutants-pops"><span>Persistent Organic Pollutants (POPs)</span></a><span>,&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-polycyclic-aromatic-hydrocarbons-pahs"><span>Polycyclic Aromatic Hydrocarbons (PAHs)</span></a><span>,&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-semi-volatile-organic-compounds-svocs"><span>Semi-Volatile Organic Compounds (SVOCs)</span></a><span>, and </span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-polychlorinated-biphenyls-pcbs"><span>Polychlorinated Biphenyls (PCBs)</span></a><span>.</span></p>

The Importance of Detecting Per- and Polyfluoroalkyl Substances (PFAS)

News from LabRulezLCMS Library - Week 36, 2026

Article

Application

Scientists

Environment

Water

Interview

The Czech Academy of Sciences (CAS) was established by Act No. 283/1992 Coll. as the Czech successor of the former Czechoslovak Academy of Sciences. It is set up as a complex of 54 public research institutions.

Czech Academy of Sciences

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Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

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SCIEX

Waters Corporation

<div><h4><strong>Navigating Challenges and Opportunities for Environmental Testing Labs Under the Revised EU Water Framework Directive</strong></h4><p><strong>The European Commission’s proposed updates to the Water Framework, Groundwater, and Environmental Quality Standards Directives are bringing new responsibilities and opportunities for environmental testing labs. With expanded pollutant lists - including PFAS, pharmaceuticals, and pesticide metabolites - and stricter monitoring and reporting requirements, the landscape of water analysis is rapidly evolving.</strong></p><p>Join the 4th Waters Environmental Webinar Series to explore how your lab can navigate these challenges and turn regulatory change into opportunity.</p><p>Register for free and partner with us to shape the future of European water quality.</p><h5><strong>Why Attend</strong></h5><p>Stay ahead of new EU regulatory demands with insights from leading experts. Gain practical guidance, share experiences with peers, and prepare your lab for the next generation of water quality standards.</p><h5><strong>Highlights</strong></h5><ul><li>New pollutant categories and analytical challenges</li><li>Updates to monitoring protocols and reporting</li><li>Innovative methods to meet revised Environmental Quality Standards</li><li>Strategic guidance for compliance and adaptation</li></ul><p><strong>Lead the change in water analysis—stay ahead, stay compliant, and make a real impact.</strong></p><h4><strong>EPISODE 6: Blue Thursdays 2026 – The Best Of</strong></h4><p>In this final session, we’ll look back at the most important things we’ve learned throughout the Blue Thursday series. We’ll explore the big trends we’re seeing, the smart tools scientists use to study the environment, and what exciting developments will be coming next.</p><blockquote><p><strong>Speaker:</strong> Claudia Rathmann (Principal F&amp;E Market Development Manager, Waters Corporation)</p><p>Experienced and passionate analytical science professional with over 20 years of technical and strategic expertise in food and environmental applications. Currently serving as Principal Market Development Manager at Waters Corporation, Claudia specializes in connecting customers with product management to deliver innovative solutions for complex analytical challenges. With a strong scientific foundation and a proven track record in both technical and marketing roles, Claudia bridges the gap between customer needs and product innovation across the EMEA region.</p><p><strong>Speaker: </strong>Janitha De-Alwis (JD) (Principal F&amp;E Market Development Manager, Waters Corporation)</p><p>Janitha De-Alwis (known as JD) is an applications chemist in the European demo lab, based in Wilmslow, UK. His main role focuses on application development work for the food and environmental sector. JD takes great pride in speaking to, and advising, many food and environmental customers. His position requires him to be reactive and proactive to the changes in the food industry, such as changing regulations, topical issues and food safety risks.</p></blockquote></div>

Blue Thursdays 2026 – The Best Of

In this final session, we’ll look back at the most important things we’ve learned throughout the Blue Thursday series.

<p><strong>Mass spectrometry has become a cornerstone technology across the 'omics' sciences, enabling researchers to characterise complex biological systems with unprecedented depth and confidence. As advances in instrumentation, separation science, ion mobility, tandem mass spectrometry, and computational data analysis continue to evolve, laboratories can achieve broader molecular coverage and more meaningful biological insights.</strong></p><p>This webinar explores the latest innovations shaping modern mass spectrometry workflows and examines how these technologies are advancing applications across proteomics, metabolomics, lipidomics, spatial omics, and related fields. Attendees will gain practical insight into how complementary mass spectrometry approaches are improving analytical performance, supporting systems-level biological understanding, and driving progress in biomarker discovery, disease research, and precision health.</p><h4><strong>Key Learning Objectives:</strong></h4><ul><li>Explain why mass spectrometry is a foundational technology across multiple 'omics' disciplines</li><li>Describe recent advances in mass spectrometry instrumentation, separation science, ion mobility, and data analysis</li><li>Understand how integrated mass spectrometry workflows are enabling systems-level insights into biological function</li><li>Recognise the impact of mass spectrometry innovations on disease research, biomarker discovery, and precision health</li></ul><blockquote><p><strong>Presenter:</strong> &nbsp;James McCullagh, PhD (Professor of Biological Chemistry, University of Oxford)</p><p>&nbsp;James McCullagh is a professor of biological chemistry and director of the Mass Spectrometry Research Facility at the University of Oxford. His research focuses on understanding the function of small molecules in complex biochemical systems with applications at the interface between chemistry, biology and medicine.&nbsp;</p></blockquote><blockquote><p><strong>Presenter:</strong> Vladimir Kardelis, PhD (Technical Product Manager, PerkinElmer)</p><p>&nbsp;Vladimir Kardelis is the Technical Product Manager for LC and LC/MS solutions at PerkinElmer. Since joining the company in 2019 as a Software Quality Assurance Engineer, he has progressed through an Application Scientist role to lead product development for LC/MS solutions. His work focuses on evaluating the QSight system’s detection limits and robustness across complex environmental and food samples, helping advance reliable LC/MS performance in real-world laboratory settings.&nbsp;</p></blockquote>

Technology Networks: Tech Spotlight - Mass Spectrometry 2026

Tech Spotlight: Mass Spectrometry 2026

Discover 2026 mass spectrometry innovations across omics disciplines. Learn how advances in separation, ion mobility, and data analysis drive precision health

<p><strong>The objective of this webinar is to demonstrate how the ZenoTOF 8600 system enables advanced, reliable, and high-throughput analysis for food safety and environmental testing.</strong></p><h4><strong>Participants will gain an understanding of how to:</strong></h4><ul><li>Achieve ultra-sensitive quantitation and confident identification of contaminants in complex matrices</li><li>Apply high-resolution workflows for quantitation and screening applications</li><li>Improve data quality, throughput, and regulatory compliance in routine laboratories</li><li>Leverage the capabilities of the ZenoTOF 8600 system to address emerging analytical challenges such as trace-level contaminants, unknown screening, and large multi-residue panels</li></ul><h4><strong>Key learning points</strong></h4><p>Participants will learn how to:</p><ul><li>Leverage ZenoTOF 8600 system capabilities</li><li>Perform advanced screening and quantitation workflows</li><li>Optimize workflows for food and environmental samples</li><li>Improve data quality and confidence</li><li>Enhance laboratory productivity</li><li>Address emerging analytical challenges: Ultra-trace detection (ppt levels) and non-target screening, and retrospective data analysis</li></ul><h4><strong>Who should attend</strong></h4><p>This webinar is designed for professionals involved in food safety and environmental analysis, including:</p><ul><li>Analytical scientists and chemists</li><li>Working with LC-MS/MS or high-resolution MS in routine or research laboratories</li><li>Laboratory managers and supervisors</li><li>Looking to improve lab efficiency, throughput, and analytical capabilities</li><li>QA/QC professionals</li><li>Responsible for ensuring data quality, compliance, and regulatory standards</li><li>Food safety specialists</li><li>Involved in testing for pesticides, mycotoxins, veterinary drugs, and contaminants</li><li>Environmental analysts</li><li>Focused on monitoring PFAS, pharmaceuticals, pollutants, and emerging contaminants</li><li>Contract testing laboratories (CROs)</li><li>Seeking high-throughput, multi-residue screening capabilities</li><li>Researchers and method developers</li><li>Interested in advanced HRMS workflows and non-target screening.</li></ul><p><i>We will send you a recording of the event</i></p><blockquote><p><strong>Speaker: </strong>Dr. Jianru Stahl-Zeng (Senior Market Development Manager, SCIEX)</p><p>Jianru has been part of SCIEX since 2001. She initially was part of the application support team and covered not only proteomics, but also small molecules applications. Jianru moved to technical marketing and focused on food and environmental applications. Since 2018 she has been managing the EMEA technical marketing team and projects. Jianru is also the Global Technical Leader for food and environmental applications. On January 2026, she took the role of Senior Market Development Manager, FEF, EMEAI.</p></blockquote>

SCIEX: Tackling emerging contaminants in food and water using the ZenoTOF 8600 system

Tackling emerging contaminants in food and water using the ZenoTOF 8600 system

Master emerging contaminant analysis in food and water. Discover how the SCIEX ZenoTOF 8600 delivers ppt sensitivity, screening, and high throughput.

SCIEX ZenoTOF 8600: Emerging Contaminants in Food & Water

<p><strong>Nitrosamine impurities continue to challenge pharmaceutical manufacturers as global regulatory requirements become more stringent. This webinar examines the analytical factors that drive successful nitrosamine and NDSRI testing, with a focus on LC/MS performance and column chemistry selection. Learn how triple quadrupole LC/MS delivers ultra‑trace sensitivity at low‑ng levels, how column chemistries (RP, HILIC, and mixed‑mode) influence separation and matrix interference, and how to optimize sample preparation and chromatography for complex drug matrices. Real‑world method development examples and regulatory perspectives from EMA, FDA, and Health Canada will round out this practical, application‑focused session.</strong></p><blockquote><p><strong>Presenter:</strong> Chander Mani&nbsp;</p><p>Chander Mani, currently a Field Technical Specialist for LC and GPC Columns, is an expert on nitrosamine workflow. He is Agilent’s Application Specialist, involved extensively in Nitrosamine method development work. He authored many application notes and ASMS posters on this subject and contributed immensely during discussions about nitrosamines in different platforms.</p></blockquote>

Agilent Technologies: Nitrosamine Testing: What Makes the Difference?

Nitrosamine Testing: What Makes the Difference?

Optimize nitrosamine and NDSRI testing in pharma using triple quad LC/MS. Learn column chemistry selection and sample prep to meet FDA and EMA standards

Nitrosamine & NDSRI Testing: LC/MS & Column Selection

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Join our experts for an in-depth look at the new Thermo Scientific™ Orbitrap™ Excedion™ Hybrid Mass Spectrometer—a next-generation HRAM platform designed to help laboratories confidently tackle today's analytical challenges while remaining ready for tomorrow's discoveries.</strong></p><p>Whether you're working in metabolomics, drug metabolism, environmental and food safety research, proteomics, or bioanalysis, the Orbitrap Excedion MS delivers the sensitivity, dynamic range, and robustness needed to detect more low-abundance compounds, improve confidence in your results, and maximize productivity. Learn how Full Scan Enhanced Dynamic Range (eDR) technology enables deeper sample coverage by revealing low-level analytes that conventional full-scan methods may miss, while maintaining outstanding quantitative performance.</p><p>This session will also explore how the Orbitrap Excedion platform is purpose-built for long-term value. With in-lab upgrade paths to the Orbitrap Excedion Pro MS, laboratories can expand capabilities as research needs evolve—protecting their investment without replacing their instrument. You'll also discover how a redesigned front-end, robust ion source, and simplified maintenance contribute to reliable, reproducible performance and greater uptime for busy laboratories.</p><p>Bring your questions and hear directly from our product experts about the innovations that are helping researchers generate more confident results today while preparing for the analytical challenges of tomorrow.</p><h4><strong>Who should attend?</strong></h4><ul><li>Scientists and laboratory managers seeking greater sensitivity, dynamic range, and confidence in HRAM mass spectrometry workflows.</li><li>Researchers working in metabolomics, DMPK, environmental and food safety, proteomics, bioanalysis, or other complex small-molecule applications.</li><li>Existing Orbitrap users and laboratories planning future instrument investments who want to understand the benefits of a scalable, upgradeable platform.</li></ul><h4><strong>What you can expect to learn</strong></h4><ul><li>How Full Scan Enhanced Dynamic Range (eDR) technology improves detection of low-abundance compounds and expands analytical coverage in complex samples.</li><li>How the Orbitrap Excedion MS delivers robust, reproducible performance with improved uptime, simplified operation, and reliable quantitative results.</li><li>How the platform's in-lab upgrade path enables your laboratory to add new capabilities as your research evolves, protecting your investment and future-proofing your workflows.</li></ul><blockquote><p><strong>Presenter: </strong>Maciej Bromirski (Sr. Product Marketing Manager, Thermo Fisher Scientific)</p><p>Maciej Bromirski has over 25 years of experience in mass spectrometry starting as an undergraduate student with late Prof. Ken Standing at the Physics Department at University of Manitoba in Winnipeg, Canada. Upon completion of his graduate studies on IR &amp; UV vacuum MALDI Q-TOF prototype MS with first oral presentation at ASMS and publications starting in 1999, Maciej undertook various roles and responsibilities with different Mass Spectrometry vendors. Since 2010 to present-day, Maciej has been fully dedicated to new product introductions and marketing developments of Q Exactive series, Orbitrap Exploris and more recently Orbitrap Excedion series MS with Thermo Fisher Scientific.</p><p><strong>Presenter: </strong>Claire Dauly (Senior Product Manager, Thermo Fisher Scientific)</p></blockquote></div></div></div>

Thermo Fisher Scientific: Ask the Expert: What to expect from the new Thermo Scientific™ Orbitrap™ Excedion™ Hybrid mass spectrometers

Ask the Expert: What to expect from the new Thermo Scientific™ Orbitrap™ Excedion™ Hybrid mass spectrometers

Explore the Orbitrap Excedion MS, featuring enhanced dynamic range, robust HRAM performance and an upgrade path to the Excedion Pro platform.

Thermo Scientific Orbitrap Excedion Hybrid mass spectrometer

<p><strong>Analytical Strategies for GLP-1 Therapeutics: Advancing Impurity Profiling with LC-UV/MS and High Resolution MS&nbsp;</strong></p><p>Glucagon-like peptide-1 (GLP-1) receptor agonists have transformed the treatment of type 2 diabetes and obesity, while increasing molecular complexity has created new analytical challenges for pharmaceutical scientists. Sequence modifications, fatty acid conjugation, and emerging multi-agonist designs require robust analytical strategies capable of detecting, characterizing, and monitoring impurities throughout development and manufacturing to ensure product quality, safety, and efficacy.</p><h4><strong>Why you should attend</strong></h4><p>This webinar will showcase complementary LC-MS approaches for the characterization and impurity profiling of GLP-1 therapeutics.</p><p>Part 1 will highlight the use of LC-UV/MS workflows as a versatile toolbox for impurity analysis of exenatide. Case studies will demonstrate how orthogonal mass information can enhance impurity detection beyond UV-based analysis, while complementary chromatographic approaches, including reverse-phase liquid chromatography (RPLC) and hydrophilic interaction liquid chromatography (HILIC), improve impurity resolution and raw material screening. Applications for characterizing amino acid sequence variants, monitoring stability-indicating impurities, and supporting risk-based decision-making in peptide manufacturing environments will be discussed.</p><p>Part 2 will focus on advanced characterization of the tirzepatide using high resolution mass spectrometry (HRMS). Through forced degradation studies under oxidative stress conditions, HRMS will be used to confidently identify degradants and elucidate impurity pathways, providing detailed structural insights into sites of molecular vulnerability and degradation mechanisms. Case studies will demonstrate how HRMS supports comprehensive characterization of complex peptide therapeutics and helps establish the analytical methodologies needed to identify and control clinically relevant impurities.</p><h4><strong>Key Learning Objectives</strong></h4><ul><li>Apply LC-UV/MS workflows to characterize impurities, sequence variants, and stability-indicating degradants in GLP-1 therapeutics.</li><li>Leverage complementary RPLC and HILIC separations to improve impurity detection and analytical confidence.</li><li>Understand how HRMS enables detailed structural characterization of GLP-1 analogs and their impurities.U<br>se forced degradation studies and degradant identification to support stability assessment and impurity control strategies.</li></ul><h4><strong>Who should attend</strong></h4><p>This webinar is designed for analytical development, LC-MS, CMC, and QC scientists working in pharmaceutical and biotechnology organizations developing or manufacturing GLP-1 and other therapeutic peptides.</p><p>Don't miss it!</p><blockquote><p><strong>Presenter: </strong>Duanduan Han, Ph.D. (Senior Scientist, Waters Corporation)</p><p>Duanduan Han is a Senior Scientist at Waters Corporation in Milford, MA. She specializes in LC–MS method development and troubleshooting, impurity profiling, and raw material screening for biopharmaceutical products and new modalities, including GLP‑1 therapeutics, lipid nanoparticles, oligonucleotides, surfactants, and monoclonal antibodies.</p><p>She earned her PhD in Chemical Engineering from Texas A&amp;M University.</p></blockquote><blockquote><p><strong>Presenter: </strong>Christopher Henry (Senior Scientist, Waters Corporation)</p><p>Chris Henry is a Principal Scientist at Waters Corporation in Wilmslow, UK. He has worked at Waters for 13 years focusing on LC-MS and GC-MS method development across small molecule and large molecule workflows using high resolution mass spectrometry.</p></blockquote>

GLP‑1 Analogs: Enhancing Impurity Profiling with LC‑UV/MS Workflows

Profile impurities in GLP-1 therapeutics using LC-UV/MS and HRMS. Learn RPLC/HILIC separation and forced degradation analysis for exenatide and tirzepatide

GLP-1 Impurity Profiling: LC-UV/MS & HRMS Workflows

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Missed the International Symposium on Chromatography 2026? Explore our posters and talks now.</strong></p><h4><strong>LC-MS/MS determination of PFAS in wild Baltic grey seal plasma for the assessment of health and developmental parameters</strong></h4><p>Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants that require highly sensitive and selective analytical methods for reliable quantification in complex biological matrices. Wildlife plasma presents additional analytical challenges due to limited sample availability, high protein and lipid content, and the risk of background contamination, making robust method development essential for accurate exposure assessment.</p><p>Following an initial LC-MS/MS screening of 31 PFAS compounds in pooled grey seal pup plasma, 10 target analytes were selected for quantitative method development. This webinar will demonstrate how the analytical workflow was designed and optimized to achieve reliable PFAS quantification from only 50 µL of plasma, including streamlined sample preparation, implementation of a delay column to minimize instrument-derived PFAS background, chromatographic separation using a Thermo Scientific Hypersil GOLD C18 Selectivity column, and quantitative analysis by isotope dilution LC-MS/MS. The presentation will conclude with the application of the validated method to plasma samples from Baltic grey seal pups and adults collected in Estonia, demonstrating its suitability for wildlife biomonitoring and providing insights into age- and sex-dependent PFAS exposure patterns.</p><h5><strong>What attendees will learn</strong></h5><ul><li>How to develop an LC-MS/MS method for PFAS in a highly complex plasma matrix</li><li>How to work with very limited sample volumes using a streamlined preparation workflow</li><li>How targeted PFAS screening can be converted into a quantitative method</li><li>How delay columns and chromatographic choices can help manage PFAS background and interferences</li><li>How validated PFAS data can support wildlife biomonitoring and toxicokinetic assessment</li></ul><h5><strong>Who should attend</strong></h5><p>This webinar is intended for analytical chemists, LC-MS/MS users, environmental monitoring scientists, toxicology researchers, and anyone working on biomonitoring of PFAS or other persistent contaminants in challenging biological matrices.</p><p>Register now to learn how a robust LC-MS/MS approach can enable reliable PFAS quantification in complex wildlife plasma samples.</p><p><i>If you are unable to attend the live webinar, please register to automatically receive a link to the on-demand recording.&nbsp;</i></p><blockquote><p><strong>Presenter: </strong>Elīna Pasečnaja, PhD (Product Application Specialist, Thermo Fisher Scientific)</p><p>Elīna Pasečnaja, PhD, is a Life Sciences Applications Specialist specializing in chromatography and mass spectrometry. With a PhD in Analytical Chemistry from Latvijas Universitāte, she combines lab expertise with environmental research, analyzing chemical pollutants to advance wildlife conservation and human health.</p></blockquote></div></div></div>

Thermo Fisher Scientific: LC-MS/MS determination of PFAS in wild Baltic grey seal plasma for the assessment of health and developmental parameters

LC-MS/MS determination of PFAS in wild Baltic grey seal plasma for the assessment of health and developmental parameters

Quantify PFAS in complex plasma samples using LC-MS/MS. Learn how delay columns and Hypersil GOLD C18 enable reliable analysis from 50 µL of sample

PFAS Determination in Seal Plasma by LC-MS/MS

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><blockquote><p><strong>Missed the International Symposium on Chromatography 2026? Explore our posters and talks now.</strong></p></blockquote><h4><strong>Advance your analysis of complex biotherapeutics</strong></h4><p><strong>Discover how novel reversed-phase column technology, a next-generation bioinert LC system, and Thermo Scientific™ Orbitrap™ mass spectrometry can work together to streamline the characterization of antisense oligonucleotides and antibody-drug conjugates.</strong></p><p>Based on the ISC 2026 lunchtime seminar, this webinar presents practical workflows for improving chromatographic separation, optimizing ion-pairing conditions, and enabling multi-level LC-MS characterization. Learn how intact, subunit, and bottom-up approaches can support antibody drug conjugates characterization and detailed profiling of critical post-translational modifications.</p><p>Gain practical insights to help accelerate method development, address challenging sample types, and build greater confidence in biotherapeutic analysis.</p><h5><strong>Key learnings</strong></h5><ul><li>Understand how reversed-phase chromatography supports the analysis of diverse biotherapeutic modalities.</li><li>Explore the benefits of a bioinert LC platform for sensitive biotherapeutic workflows.</li><li>Learn how design of experiments can optimize ion-pairing conditions for oligonucleotide LC-MS analysis.</li><li>See how Orbitrap mass spectrometry enables multi-level ADC characterization.</li><li>Discover how intact, subunit, and bottom-up workflows support DAR determination and PTM profiling.</li></ul><h5><strong>Who should attend</strong></h5><p>This webinar is designed for scientists and analysts working in biopharmaceutical characterization, analytical method development, oligonucleotide and ADC analysis, and LC-MS workflow development. It is particularly relevant to professionals supporting biotherapeutic development, comparability studies, and regulatory readiness.</p><p><i>Unable to attend the broadcast? Register anyway, and you will automatically receive access to the recording.</i></p><blockquote><p><strong>Presenter: </strong>Sara Carillo, PhD (Principal Scientist, Senior Manager, NationalBioprocessing Research and Training (NIBRT))</p><p>Sara Carillo earned her Ph.D. in chemical sciences from the University of Naples Federico II, where she studied polysaccharides and glycoconjugates using NMR and mass spectrometry. She joined NIBRT in 2015 and is nowPrincipal Scientist, developing MS-based methods to better characterize biomanufacturing processes and biopharmaceutical complexity.</p></blockquote><blockquote><p><strong>Presenter: </strong>Sukhdev Bangar (Senior Product Marketing Manager, Thermo Fisher Scientific)</p><p>Sukhdev holds a BSc in Pharmaceutical Sciences from De Montfort University and began his career in LC and LC-MS analysis at GSK and AstraZeneca. He later held several roles at Waters in LC-MS applications and product management before joining Thermo Fisher Scientific, where he now leads marketing for the Vanquish analytical LC portfolio.</p></blockquote></div></div></div>

Thermo Fisher Scientific: ASOs, ADCs, and Other Therapeutics: Advanced Characterization with Novel Reversed-Phase Columns and Integrated LC–MS Platform

ASOs, ADCs, and Other Therapeutics: Advanced Characterization with Novel Reversed-Phase Columns and Integrated LC–MS Platform

Characterize ASOs and ADCs with bioinert LC, novel RP columns, and Orbitrap MS. Learn multi-level LC-MS workflows, DAR determination, and PTM profiling

Advanced ASO & ADC Characterization via Bioinert LC-MS

<p><strong>Synthetic peptides like GLP-1 analogs (e.g., semaglutide, tirzepatide) present analytical challenges due to complex modifications and potential degradation products. High resolution accurate mass spectrometry (HRMS) offers the sensitivity, resolution, and mass accuracy needed for confident sequence confirmation and impurity profiling.</strong></p><p>In this Tech Talk, attendees will discover how integrated workflows from high-throughput screening using the <strong>INTACT Mass App</strong> to detailed degradation characterization with UNIFI streamline synthetic peptide analysis, support quality attribute monitoring, and ensure regulatory compliance.</p><h5><strong>Certificate of attendance</strong></h5><ul><li>If you attend the live TechTalk, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.&nbsp;</li><li>If you view the on-demand TechTalk, you can request a certificate of attendance by emailing editor@selectscience.net.</li></ul><h5><strong>TechTalk details</strong></h5><ul><li><strong>Cost: </strong>Free to attend</li><li><strong>Location: </strong>Online</li><li><strong>Duration: </strong>20 minutes</li></ul><p><i>Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on-demand recording once it becomes available.</i></p><h5><strong>Who should attend?</strong></h5><p>This event is perfect for:</p><ul><li>Bioanalytical scientists</li><li>Pharmaceutical R&amp;D researchers</li><li>QC/QA laboratory managers</li><li>Contract Research Organisation (CRO) scientists</li><li>Mass spectrometry specialists</li></ul><h5><strong>What will this webinar cover?</strong></h5><ul><li>The advantages of high resolution accurate mass spectrometry (HRMS) over nominal mass systems for resolving near-isobaric impurities and peptide variants.</li><li>How high-throughput screening tools enable rapid mass confirmation, sequence verification, and routine purity reporting.</li><li>Strategies for comprehensive qualitative analysis and tracking of forced degradation products.</li></ul><blockquote><p><strong>Presenter:</strong> Jonathan Fox (Biologics Consulting Scientist, Waters Corporation)</p><p>Jonathan Fox is a Biologics Consulting Scientist at Waters Corporation, specializing in advanced high resolution accurate mass spectrometry (HRMS) applications for biopharmaceutical research and development. With extensive expertise in biotherapeutic characterization, analytical chemistry, and liquid chromatography-mass spectrometry (LC-MS) workflows, he focuses on developing innovative solutions for complex molecules, including synthetic peptides, oligonucleotides, and therapeutic proteins. He works closely with pharmaceutical and biotech organizations to optimize quality attribute monitoring and impurity profiling strategies.</p></blockquote>

SelectScience: GLP-1 & GIP under the lens: HRMS strategies for synthetic peptide profiling

GLP-1 & GIP under the lens: HRMS strategies for synthetic peptide profiling

Explore HRMS workflows for synthetic peptide analysis, including sequence confirmation, impurity profiling, purity assessment, and degradation characterization.

GLP-1 & GIP HRMS strategies for synthetic peptide profiling

<p><strong>Join us for an insightful webinar exploring advanced LC-MS/MS approaches for the quantitative analysis of nitrosamine impurities using the SCIEX novus V55 system.</strong></p><p>This session will highlight highly sensitive and selective LC-MS/MS workflows for the detection and quantitation of trace-level nitrosamine impurities in pharmaceutical products. Learn about optimized sample preparation, chromatographic separation, and MRM-based quantitation strategies designed to deliver accurate, reproducible, and regulatory-compliant results.</p><p>The webinar will also cover method development and validation considerations, analytical challenges associated with nitrosamine analysis, and best practices to support global regulatory requirements for routine quality control and risk assessment.</p><blockquote><p><strong>Speaker: </strong>Dr. Dev Kant Shandilya (Director - Analytical Research and Development, Fresenius Kabi)</p><p>Dr. Devkant is an accomplished analytical chemistry leader with over 26 years of experience in pharmaceutical analytical R&amp;D, specializing in APIs, drug products, peptides, and complex generics. He has extensive expertise in LC-MS/MS, impurity profiling, nitrosamine and elemental impurity analysis, method development and validation, and regulatory submissions (DMF, NDA, and ANDA). Holding a Ph.D. in Chemistry, an MBA, and an M.Sc. in Analytical Chemistry, Dr. Devkant has successfully led high-performing analytical teams and driven innovation in pharmaceutical development and regulatory compliance.</p><p><strong>Topic: LC-MS-Based Quantitative Analysis of Nitrosamines from Leachable</strong></p><p><strong>Key Highlights:</strong></p><ul><li>Ultra-trace detection and quantitation of nitrosamines using highly sensitive LC-MS methodologies.</li><li>Optimized sample preparation and chromatographic separation for enhanced selectivity and analytical robustness.</li><li>Validated workflows supporting regulatory-compliant risk assessment of nitrosamine impurities arising from leachable sources.</li></ul><p><strong>Speaker: </strong>Aman Sharma (Sales Development Manager, Sciex India Pvt Ltd)</p><p>Aman Sharma has over 18 years of experience in analytical sciences, spanning analytical instrumentation, application support, and strategic marketing. He specializes in understanding market needs, driving demand generation, and developing innovative marketing initiatives. Known for his strategic mindset, customer-centric approach, and collaborative leadership, he has successfully bridged technical expertise with business growth.</p><p><strong>Topic: High-Sensitivity Quantitation of Nitrosamine Impurities with the SCIEX novus V55 system</strong></p><p><strong>Key Highlights:</strong></p><ul><li>Enhanced sensitivity for low-level nitrosamine detection.</li><li>Robust quantitative performance with optimized LC-MS/MS workflows.</li><li>Streamlined method development for routine quality control and regulatory compliance.</li></ul></blockquote>

SCIEX: LC-MS/MS Analysis of Nitrosamines using novus V55

LC-MS/MS Analysis of Nitrosamines using novus V55

Explore LC-MS/MS workflows for trace nitrosamine analysis with the SCIEX novus V55, including MRM quantitation, validation, and regulatory compliance.

LCMS webinars focusing on LC/MS/MS - page 1