An international team led by researchers from CEITEC Masaryk University has developed a computational method for designing entirely new antimicrobial peptides – short proteins capable of killing bacteria. Instead of relying on the lengthy process of searching for suitable molecules in nature, the researchers can now use molecular simulations to predict their properties and design new molecules with specific functions. The resulting peptides successfully eliminated bacteria resistant to conventional antibiotics and proved effective in preclinical mouse models. The findings introduce a new approach to developing future antibiotics as well as other biologically active peptides.According to the World Health Organization, antibiotic resistance is one of the greatest global health threats of our time. Every year, the number of bacteria resistant to available antibiotics continues to grow. At the same time, developing new drugs is a lengthy and costly process in which most candidate molecules ultimately fail.Researchers at CEITEC Masaryk University have therefore taken a different approach. Rather than searching randomly for antimicrobial compounds, they developed a method for designing them based on molecular design principles. Using molecular simulations, they analysed around 150 peptides in detail and identified the rules that govern the design of molecules capable of forming stable pores in bacterial membranes. These tiny openings disrupt the membrane barrier, causing bacteria to lose control of their internal environment and ultimately die. "We discovered how to arrange specific amino acids so that the resulting peptides form pores in bacterial membranes. This now allows us to generate an enormous number of peptide candidates and select those with the properties we are looking for," says <a target="_blank" rel="noopener noreferrer" href="https://www.ceitec.eu/prof-robert-vacha-ph-d/u27252">Robert Vácha</a> from CEITEC Masaryk University, who led the research.The researchers validated the most promising peptide designs experimentally. They confirmed their activity against a group of the most dangerous antibiotic-resistant bacteria. The best results were achieved against Acinetobacter baumannii, which the World Health Organization classifies as a priority drug-resistant pathogen. The team also demonstrated that their most successful peptide does not damage human red blood cells and shows no significant toxicity towards human cells. Its efficacy was further confirmed in two preclinical mouse models of bacterial infection.The significance of the study lies not only in identifying a new antibiotic candidate but, more importantly, in establishing a new design strategy. Based on their findings, the researchers developed a set of design principles and 52 sequence templates that can be used to design approximately 10 trillion molecules, providing other research teams with a framework for developing new membrane-disrupting peptides. The same principle that proved successful against bacteria could also be applied in the future to develop anticancer therapeutics, biosensors, or targeted drug delivery systems."Until now, researchers have mostly searched for biologically active molecules created by nature and only then investigated how they work. We reversed this process. First, we studied which molecular properties are required for a particular mechanism of action – in our case, the ability to stabilize membrane pores – and then used this knowledge to design entirely new peptides that make such pores. This approach could significantly accelerate the development of new medicines and help us keep pace with the growing challenge of antibiotic resistance," adds Robert Vácha, who has received ERC grants for his research.The study was carried out in collaboration with researchers from the University of Pennsylvania, the University of Groningen, Palacký University Olomouc, and the Institute of Microbiology of the Czech Academy of Sciences. The results were published in <a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41589-026-02269-z.epdf">Nature Chemical Biology</a>.<blockquote><h4>The original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.nature.com/articles/s41589-026-02269-z#citeas">Computational design of antimicrobial peptide nanopores</a></h4>Rahul Deb, Marcelo D. T. Torres, Ivo Kabelka, Jan Přibyl, Kateřina Dvořáková Bendová, Edo Vreeker, Markéta Koběrská, Gabriela Balíková Novotná, Miloš Petřík, Giovanni Maglia, Cesar de la Fuente-Nunez &amp; Robert VáchaNat. Chem. Biol., 2026, 22, 1–12<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1038/s41589-026-02269-z">https://doi.org/10.1038/s41589-026-02269-z</a>&nbsp;<h6>Licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>Antibiotic resistance is a global health threat, driving the need for new molecules that kill bacteria via nontraditional mechanisms. Here, we present a computational de novo design strategy for α-helical peptides that self-assemble into large, stable and membrane-spanning nanopores with antimicrobial activity, including in vivo efficacy against drug-resistant pathogens. Molecular dynamics simulations guided the selection of sequences for transmembrane barrel-stave pore formation, which were validated by microscopy, electrophysiology and fluorescence assays. Using computational and experimental analyses, including negative design controls, we developed general design guidelines and 52 modular sequence templates with tunable antimicrobial, pore-forming properties. Mechanistic studies confirmed bacterial cytoplasmic membrane disruption via designed nanopore formation. A tuned lead peptide selectively killed drug-resistant ESKAPEE bacteria, including Acinetobacter baumannii, without harming human cells, and showed anti-infective efficacy in preclinical mouse infection models. The framework presented here enables the design of synthetic peptide nanopores for precision antimicrobials, anticancer agents, molecular sensors and delivery systems.

New Antibiotics Designed on a Computer: Scientists Develop a Blueprint for Building Molecules Against Drug-Resistant Bacteria 

A new study published in Nucleic Acids Research identifies short “start–stop” elements as highly effective regulators of protein synthesis in human cells. The study was co-led by Leoš Shivaya Valášek from IMIC CAS.<section><div><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MBU_Nenapadne_start_stop_brany_reguluji_tvorbu_bilkovin_v_bunce_2_4d91bb348d.jpg" alt="MBU: Unassuming Start–Stop “Gates” Regulate Protein Production in Cells" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MBU_Nenapadne_start_stop_brany_reguluji_tvorbu_bilkovin_v_bunce_2_4d91bb348d.jpg 245w," sizes="100vw" width="720" height="390"><section><div>An international team of scientists has described a&nbsp;previously overlooked mechanism that regulates the levels of important proteins in human cells. A new study published in Nucleic Acids Research reveals that short regulatory “start–stop“ elements act as highly effective speed-limiting gates of protein synthesis. Compared with previously known regulatory sequences, these elements were found to suppress protein production even more efficiently. At the same time, they help maintain low but stable levels of important proteins in cells, even under stress conditions. The study brought together scientists from the United States, the Czech Republic, Canada, and Sweden. Leoš Shivaya Valášek, Head of the Laboratory of Regulation of Gene Expression at the Institute of Microbiology of the Czech Academy of Sciences (IMIC CAS) was a&nbsp;co-author and one of the corresponding authors of the study.</div></section><section><div>During protein production, ribosomes read and translate information encoded in messenger RNA (mRNA) into amino acids, which are then assembled into a&nbsp;new protein. The researchers focused on an unusual sequence in which a&nbsp;start signal is immediately followed by a&nbsp;stop signal. As a&nbsp;result, the ribosome receives instructions to begin and terminate translation almost simultaneously. Although such an arrangement may appear illogical, it proved to be an important regulatory tool.Start–stop motifs are found in more than 1,400 human genes and are particularly common in genes that control cellular signaling pathways, the stress response, or the activity of transcription factors—that is, proteins that regulate the activity of other genes. These genes must be tightly controlled because even small changes in the amount of their protein products can have significant biological consequences.<h4>Resilience Under Stress</h4>The researchers tested the activity of this regulatory mechanism under stress conditions, including in the ATF4 gene, which plays a&nbsp;key role in the so-called integrated stress response. Cellular stress is typically associated with a&nbsp;global reduction in protein synthesis. The authors demonstrated that regulation mediated by start-stop elements is largely independent of the overall state of translation initiation and therefore remains effective even under cellular stress.<h4>A Stronger Brake Than Known Regulatory Elements</h4>The team compared start–stop sequences with similar regulatory regions known as uTranslons. Although both types of elements suppress protein synthesis, the start–stop sequences proved to be significantly more effective. Ribosomes remain associated with these motives for longer before proceeding to the main coding region of the gene.“Start-stop sequences are specialized regulatory elements that ensure increased ribosome retention, thereby allowing for fine-tuning translation,” says Leoš Valášek from IMIC CAS.The study expands our understanding of how cells fine-tune protein synthesis and may ultimately contribute to research on &nbsp;certain cancer and neurodegenerative disorders, and other diseases linked to disrupted protein production.</div></section><blockquote><h4>The original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://academic.oup.com/nar/article/54/13/gkag627/8725953?login=false">Elongationless start–stop elements are stress-resilient translation gates that are more repressive than uTranslons</a></h4>Justin Rendleman, Solomon A Haizel, Shaohuan Wu, Laurelle Lee Young, Junjie Liu, Xinyi Ge, Huijing Zou, Mahabub Pasha Mohammad, Matthew Pressler, Shuvadeep Maity, Vladislava Hronová, Zhaofeng Gao, Anna Hermannová, Anna Smirnova, Amy Lei, Kristina Allgoewer, Daniel Sultanov, Will Edward Hinckley, Ziyue Cheng, Lauren Shelby, Tanubrata Dey, Krzysztof J Szkop, Ivan Topisirovic, Ola Larsson, Maria Hatzoglou, Leoš Shivaya Valášek, Christine VogelNucleic Acids Research (2026), Volume 54, Issue 13&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1093/nar/gkag627">https://doi.org/10.1093/nar/gkag627</a><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>Start–stop elements are translation regulatory elements in 5′ untranslated regions (UTR) of eukaryotic transcripts, consisting of a start codon immediately followed by a stop codon. In contrast to canonical upstream Translons (uTranslons), they exclude elongation which creates unique properties. We conducted a comprehensive, carefully controlled comparison of human start–stop elements and uTranslons both at a genome-wide level and with targeted reporter assays. We found that start–stops and uTranslons were similar with respect to their presence in the 5′ UTRs of hundreds of genes, in particular transcription factors and signaling molecules, the low transcript levels of the corresponding genes, short RNA half-lives, and the negative effect on downstream translation. However, start–stop containing genes were translationally even more repressed than genes with uTranslons. Analysing the start–stop architecture and diverse ribosome footprinting datasets, we found evidence for a start–stop-specific mechanism that involves repeat cycling between initiation, termination, ribosome splitting, and 60S rejoining—a process possibly modulated by ASCC3 and eIF1. This cycling explained increased ribosome retention at start–stops and was—in contrast to ribosome retention at uTranslons—independent of the global initiation state. Finally, we showed that the start–stop element in human ATF4 augments the core regulatory model by controlling translation of the uTranslons.</div></section>

Unassuming Start–Stop “Gates” Regulate Protein Production in Cells

Why Biologics QC Is So Much Harder Than Small Molecule Pharma

Article

Scientists

Interview

Science and research

The Czech Academy of Sciences (CAS) was established by Act No. 283/1992 Coll. as the Czech successor of the former Czechoslovak Academy of Sciences. It is set up as a complex of 54 public research institutions.

Czech Academy of Sciences

Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Merck

The Analytical Scientist

Technology Networks

Restek Corporation

SCIEX

Bulk gas supply in the form of liquid nitrogen dewars and cylinders present laboratories with safety risks stemming from the frequent need to handle and manage gas supplies. Laboratory staff are at risk of injury every time they need to move a gas cylinder and a leak from bulk storage can result in the development of a potentially deadly atmosphere.
Flammable gases such as hydrogen present additional risks of fire or explosion, which need to be addressed through safe gas handling, storage and detection in the laboratory, increasing the cost of their use.
<h3>Attend this webinar to learn about:</h3>
<ul>
<li>General gas cylinder safety tips</li>
<li>Risks associated with bulk gas supply</li>
<li>The risks of using nitrogen and hydrogen in the laboratory</li>
<li>Benefits of using a gas generator to supply nitrogen and/or hydrogen</li>
</ul>
<blockquote>
Presenter: Dr. Ed Connor (Product Manager, PEAK Scientific)
</blockquote>

Unsplash/Julia Lobkova: Gas Safety in Your Laboratory

Gas Safety in Your Laboratory

Please join us for a webinar on how to overcome challenges related to the quantification of cyclic peptides with the latest triple quadrupole technology.
<h3>Agenda</h3>
<ul>
<li>11:00 a.m. Quantification of cyclic peptides</li>
<li>11:25 a.m. Why a gas generator matters for your mass spectrometer</li>
<li>11:55 a.m. Q&amp;A</li>
</ul>
The evaluation and quantification of trace-level cyclic peptides in biological matrices have remained challenging due to the high baseline interference in matrices, which can affect:
<ul>
<li>The selectivity of the quantification</li>
<li>The production of abundant fragment ions for the quantification</li>
<li>The sensitivity of the quantification</li>
</ul>
Join this webinar and see how the new SCIEX 7500 system is ready to overcome the challenges of the low-level quantification of cyclic peptides with its:
<ul>
<li>Enhanced desolvation and ion transmission based on the E Lens probe</li>
<li>Proven dynamic range, precision, accuracy, linearity and reproducibility thanks to the D Jet ion guide</li>
<li>Curved, high-energy and efficient collision cell to provide more fragment ions</li>
</ul>
We will also discuss how gas is used in the mass spectrometer and the importance of having a reliable and validated source of gas for your SCIEX instrument to achieve the best results.
<blockquote>
Presenter: Cathy Lane (EMEAI Applications Lead, Pharma and Peptide Quantification, SCIEX)
</blockquote>
<blockquote>
Cathy joined SCIEX in 2006 as a Support Specialist, focusing initially on protein and peptide applications. She has recently taken up the role of EMEAI Applications Lead for Pharma and Peptide Quantification. She has more than 20 years of experience in the development of LC-MS methods for multiple applications in a range of industries. Cathy obtained her PhD in mass spectrometry-based proteomics from the University of London School of Pharmacy, and prior to that spent several years working in doping control at the Drug Control Center at King’s College London.
</blockquote>
<blockquote>
Presenter: Dan Leigh (Senior Support Manager UK, SCIEX)
</blockquote>
<blockquote>
Dan joined SCIEX in 2007 as a Support Specialist focused primarily on small molecule workflows. Since 2016, Dan has held the role of Senior Support Manager, leading the SCIEX UK Support team and running the UK lab facility. In 2020, he successfully relocated the SCIEX UK Centre of Innovation to its new home at Alderley Park. Dan has almost 20 years of LC-MS experience from his time at SCIEX and prior roles in the pharma/CRO industry.
</blockquote>
<blockquote>
Presenter: Bruce Peat (Marketing Manager, Peak Scientific)
</blockquote>
<blockquote>
With 7 years of experience in marketing gas generation technology for analytical laboratories, Bruce has been championing Peak Scientific gas generator solutions and rapid-response, on-site services designed to help labs using LC-MS and GC instruments maximize their uptime.Most recently, Bruce has been showcasing Peak Scientific’s market-leading Genius XE SCI 2 product, developed with SCIEX, which supports both the SCIEX 7500 system and the Echo® MS system.
</blockquote>

SCIEX: Overcoming the quantification of cyclic peptides with the latest triple quadrupole technology

Overcoming the quantification of cyclic peptides with the latest triple quadrupole technology

This forum, hosted by The Analytical Scientist and featuring speakers from Peak Scientific, Shimadzu and Agilent, and more, will explore the latest LC-MS trends and innovations. Register to discover how recent advances in LC-MS are making waves across a broad range of exciting application areas.
At the end of the event, we’ll be hosting a live question-and-answer session with all of the speakers so you can dive a little deeper into any of the topics covered during the forum discussion. 
Join us today – register to make sure you claim your spot for the LC-MS Forum!
<blockquote>
Presenter: Gregor Thompson (Product Manager, PEAK Scientific)
</blockquote>
<blockquote>
Gregor Thompson joined PEAK Scientific in October 2021 as a Product Manager and has been leading on product improvements and new product development of nitrogen generators designed for LC/MS.
</blockquote>
<blockquote>
He has a varied portfolio of products and works closely with the major instrument manufacturers worldwide to ensure all new developments are optimised for LC/MS.
</blockquote>
<blockquote>
Presenter: Hannah Florance, PhD (LC/MS Application Specialist, Agilent)
</blockquote>
<blockquote>
In 2006, Hannah gained her PhD at the University of Edinburgh in non-covalent protein interactions in solution and the gas phase under the tutelage of Prof. Perdita Barran.
</blockquote>
<blockquote>
Hannah is currently an LC/MS applications specialist for Agilent, based in Cheadle, UK and has had multiple roles in the life sciences research, starting as a protein chemist, before moving into the proteomics and metabolomics fields.
</blockquote>
<blockquote>
Presenter: Stéphane Moreau (Product Manager , Shimadzu)
</blockquote>
<blockquote>
Stephane Moreau obtained his diploma in 1994 at INSA (National Institute of Applied Sciences) in Rouen, France, in fine chemistry and engineering specializing in chemical process engineering.
</blockquote>
<blockquote>
He then started his professional career in laboratory equipment distribution before he joined the brand-new Shimadzu France subsidiary in 2002. Since then, he has held many positions inside Shimadzu group to develop the MS range business. Since September 2013, he has been product manager for the MS range with Shimadzu Europe.
</blockquote>

LC/MS Forum

Featuring speakers from Peak Scientific, Shimadzu and Agilent, and more, will explore the latest LC-MS trends and innovations. 

Recent technological advancements have greatly expanded the options for high-quality mass spectrometry equipment. With significant progress in GC-MS, LC-MS, and gas generators, critical analyses can now be conducted with enhanced effectiveness and efficiency.
Join our technical webinar to gain a comprehensive overview of cutting-edge MS equipment and the latest innovations in utilizing hydrogen as a carrier gas. Discover the advancements, including Agilent&#39;s quadrupole time-of-flight LC-MS and PEAK Scientific&#39;s nitrogen gas generator, designed to optimize competitiveness and productivity in your analytical workflows.
<h5>Attend this webinar to:</h5>
<ul>
<li>Learn about why there is a huge drive to switch to hydrogen as a carrier gas for GC</li>
<li>Discover how to achieve time-saving efficiencies and meet future challenges with instrument intelligence using the latest quadrupole time-of-flight LC-MS</li>
<li>Understand how a gas generator can save you time and money as well as improve your lab’s sustainability</li>
</ul>
<h3>1. Novel Mass Spectrometry Technologies Expand Future of Biomarker Discovery Research</h3>
<ul>
<li>Diane Turner (Director and Senior Consultant, Anthias Consulting Ltd)</li>
</ul>
Gas chromatography - mass spectrometry (GC-MS) instruments are used for a wide variety of critical analyses and presents a topic of growing importance as the industry collectively moves away from helium as a carrier gas due to availability and pricing to suitable alternatives such as hydrogen.
In this webinar, Dr. Diane Turner from Anthias Consulting Ltd will focus on the innovations around using hydrogen as a carrier gas and explore the associated benefits as well as address the challenges involved.
<h5>In his talk, she will cover:</h5>
<ul>
<li>Why there is a huge drive to switch to hydrogen as a carrier gas for GC</li>
<li>The associated benefits and negatives of using hydrogen</li>
<li>A ‘to do’ list of parameters to re-optimize when switching to hydrogen</li>
</ul>
<h3>2. Be Ready for Future Challenges With an Intelligent LC-MS Solution</h3>
<ul>
<li>Christian Klein (Product Manager LC/Q-TOF and IM-QTOF, Agilent Technologies)</li>
</ul>
Many labs are faced with an ever-increasing sample load, while instrumentation and resources remain at a steady level. As a consequence, instrument throughput and uptime are critical factors to maintain competitiveness and productivity.
In this webinar, Dr. Christian Klein will show how you can meet these challenges with the newest time-of-flight LC-MS from Agilent. See examples of complete workflows demonstrating performance, robustness and throughput for food safety screening applications.
<h5>In his talk, he will cover:</h5>
<ul>
<li>Time-saving efficiencies and meeting future challenges with instrument intelligence</li>
<li>How to implement end-to-end workflows for food safety to produce meaningful results</li>
<li>How to identify and quickly assess compounds in question</li>
</ul>
<h3>3. How Can a Gas Generator Benefit Your Lab?</h3>
<ul>
<li>Petra Gierga (Product Manager, PEAK Scientific)</li>
</ul>
Labs face challenges every day and lab gas should not be one of these problems. On-site gas generators play a pivotal role in helping labs to streamline workflows while providing high-quality gas for LC-MS analysis.
In this webinar, Petra Gierga from PEAK Scientific will be discussing the benefits a gas generator can provide your lab over cylinders, dewars or bulk supply. Removing the need for repeated cylinder deliveries, cylinder contracts, manual handling and changing of cylinders – an in-house gas generator can reduce costs, increase productivity and improve your lab’s sustainability efforts.
<h5>In this talk, she will cover:</h5>
<ul>
<li>How a gas generator can save you time</li>
<li>The economic benefits of using a gas generator</li>
<li>The advantages a gas generator has for your labs workflows and long-term sustainability goals</li>
</ul>

Technology Networks: Breaking the Boundaries: The Latest Innovations in Mass Spectrometry

Breaking the Boundaries: The Latest Innovations in Mass Spectrometry

Technical webinar: overview of cutting-edge MS equipment and the latest innovations in utilizing H2 as a carrier gas, LC/Q-TOF or N2 gas generators.

The Latest Innovations in Mass Spectrometry

Join this webinar to explore the utility of hydrogen in chemical research, its associated risks, and a safer laboratory solution: H-Genie® Lite. This innovative, compact hydrogen generator employs unique patented cell technology to convert water into high-purity hydrogen gas, reaching pressures up to 50 bar (725 psi). As an ideal replacement for conventional hydrogen cylinders, it not only boosts lab safety but is also perfect for filling autoclaves and pressured containers.
Subsequently, we will delve into metal-catalyzed hydrogenation reactions. Heterogeneous catalysts like Pd/C are commonly employed for nitro group reductions and hydrogenation of carbon-carbon and carbon-heteroatom double bonds. These catalysts also aid in O- and N- deprotection, yielding respective alcohols or amines, and in asymmetric hydrogenation reactions.
We’ll discuss the core principles of hydrogenation, featuring both heterogeneous and homogeneous catalysts, and highlight their significance in industrial applications. H-Genie® Lite seamlessly integrates with both batch and continuous flow chemistry hydrogenation processes.
<blockquote>
Presenter: Nándor Kánya, PhD (Head of Experimental Chemistry, ThalesNano)
</blockquote>
<blockquote>
Nándor graduated from Budapest University of Technology and Economics as a Pharmaceutical Engineer in 2016, followed by a PhD degree in synthetic organic chemistry from the University of Debrecen in 2021. He joined ThalesNano in 2021 as an Application Scientist and became the leader of Experimental Chemistry in 2022.
</blockquote>
<blockquote>
Presenter: Thomas Colacot, PhD (R&amp;D Fellow and Director of Global Technology Innovation, Merck KGaA, Darmstadt, Germany)
</blockquote>
<blockquote>
Thomas J. Colacot holds a Ph.D. in chemistry and an MBA. He joined MilliporeSigma in 2018 and currently serves as an R&amp;D Fellow and Director of Global Technology Innovation in the Life Science Business division. He is an expert in organometallics and homogeneous catalysis and has a strong track record of commercializing innovative products. Colacot has published over 120 peer-reviewed articles and holds 67 international patents. He has been recognized with various awards, including a lifetime achievement award from the Chairman and CEO of Merck KGaA, Darmstadt, Germany. From 1995 to 2018, he was instrumental in establishing a successful homogeneous catalysis program at Johnson Matthey.
</blockquote>

Safe Hydrogenation in the Lab

Safe Hydrogenation in the Lab with H-Genie® Lite

Safe Hydrogenation in the Lab H-Genie® Lite

Laboratories rely on efficiency, safety, and cost-effectiveness to optimize their workflows. One of the most significant factors in achieving these goals is ensuring a reliable supply of nitrogen gas. Organomation’s latest webinar, Improving Laboratory Workflows through Nitrogen Generation, explores how nitrogen generators can revolutionize lab operations by eliminating the need for gas cylinders.<h4>The Challenge: Gas Cylinders vs. On-Site Nitrogen Generation</h4>Traditionally, many laboratories depend on nitrogen cylinders, which come with hidden costs and logistical challenges.&nbsp;These include:<ul><li>Rental Fees: The recurring costs of renting cylinders add up over time.</li><li>Refill and Delivery Charges: Market fluctuations and scheduling conflicts can delay deliveries, leading to downtime.</li><li>Safety Concerns: Handling and transporting high-pressure cylinders can pose workplace hazards.</li><li>Space Limitations: Storing multiple bulky cylinders takes up valuable lab space.</li></ul>Organomation’s David Oliva shared a real-world example of a lab located in a multi-floor building without an elevator. Employees were forced to carry heavy gas cylinders up and down staircases, creating an unnecessary safety risk. Another lab experienced a several-week delay in research due to a miscommunication in their cylinder delivery. Situations like these highlight the need for a more reliable and efficient solution.<h4>The Solution: On-Site Nitrogen Generation</h4>Nitrogen generators provide labs with a cost-effective, continuous nitrogen supply while addressing many of the pain points associated with gas cylinders.Key benefits include:<ul><li>Significant Cost Savings: Eliminates rental, refill, and delivery fees.</li><li>Operational Efficiency: Reduces workflow disruptions by ensuring an uninterrupted nitrogen supply.</li><li>Enhanced Safety &amp; Convenience: Removes the need to store and handle high-pressure cylinders.</li><li>Space Optimization: Compact generators free up valuable lab space.</li><li>Sustainability: Reduces the environmental impact associated with nitrogen gas transportation.</li></ul>To help labs assess whether a nitrogen generator is a worthwhile investment, Organomation has developed a payback calculator. Many labs find that they achieve a full return on investment within 1-2 years.<h3>Real-World Success Stories</h3>Several laboratories have already made the switch to nitrogen generators, experiencing improved efficiency and cost savings.<h4>Temple University’s McKenzie Environmental Engineering Research Group</h4>Temple University’s research group, which concentrates PFAS sample extracts for mass spectrometry, made the transition to nitrogen generation to combat rising costs associated with tank rentals, delivery, and surcharges. Their investment in the NITRO-GEN generator allowed them to meet growing sample throughput requirements without the logistical headaches of cylinder replacements. With a compact design and plug-and-play functionality, the generator seamlessly integrated into their workflow.<h4>Moyo Lab at Louisiana State University</h4>The Moyo Lab, which studies nutrient movement across habitats, relies on nitrogen evaporation to remove excess chloroform from their extraction samples. Dissatisfied with nitrogen cylinders, they opted for the NITRO-GEN+ generator to streamline their operations.Lab Manager and Assistant Professor of Biology Sydney Moyo shared his experience:"I love the NITRO-GEN+ for many reasons. First, a vital benefit is that I can move the generator around the department because it has wheels. When I used cylinders, I had difficulty moving them around the lab. Second, when the NITRO-GEN+ is not in use, I can safely store it in a corner in my lab because it only takes up a little space. Third, the NITRO-GEN+ is also very quiet and is one of the quietest generators we have used in the lab. Fourth, I love that there is less risk of running out of nitrogen as I always have a 24/7 supply when needed. Lastly, the NITRO-GEN+ is so easy to use that students in the Moyo Lab can use it with little training.”With user-friendly features and portability, the NITRO-GEN+ has proven to be a game-changer for the Moyo Lab, ensuring they never run out of nitrogen while simplifying lab operations.<h4>Making the Right Choice for Your Lab</h4>To assist labs in selecting the best nitrogen generator for their needs, Organomation offers a generator recommendation chart that matches evaporator models with the most suitable generator options. Additionally, their customer service team is always available to help labs find the best solution for their workflow requirements.<blockquote>Presenter: David Oliva (General Manager of Organomation)One of Oliva’s favorite responsibilities is visiting academic institutions and environmental laboratories around the world. He was named to the 40 Under Forty Class of 2022 from the Worcester Business Journal and is a winner of a B2B Innovator Award from Demand Gen Report.</blockquote>

Organomation: Why Laboratories are Switching to Nitrogen Generators

Why Laboratories are Switching to Nitrogen Generators

Explore how nitrogen generators enhance lab safety and efficiency. Learn how to cut costs and ditch gas cylinders in Organomation's latest webinar.

When it comes to gas supply for LC-MS, gas generators are now the gas source of choice as the most cost-effective and reliable method of supplying the high flow LC-MS instruments require. Find out more about the innovative technology behind Peak’s products and market-leading after sale support offered by Peak around the globe, all designed to keep your lab running day in, day out.
<h3>Learning Objectives:</h3>
<ul>
<li>Improving your lab’s productivity</li>
<li>Nitrogen gas generator technology and how it works</li>
<li>Maintaining your nitrogen gas generator</li>
</ul>
<blockquote>
Presenter: Dr. Ed Connor (Product Manager, Peak Scientific)
</blockquote>
<blockquote>
After gaining a PhD from ETH Zurich and working as a lab manager for the University of Zurich, Dr. Ed Connor joined Peak Scientific as a Product Manager responsible for the ongoing management and development of gas generator solutions. Dr. Ed Connor has also produced a number of articles and application notes for Peak Scientific’s gas generator ranges for LC-MS and GC applications.
</blockquote>

Peak Scientific: Increasing Lab Uptime with a Nitrogen Gas Generator

Increasing Lab Uptime with a Nitrogen Gas Generator

This presentation will give an overview of the selection of air sampling media, covering both whole air and sorbent sampling techniques. The advantages and disadvantages of each will be addressed, as well as proper techniques for cleaning, sampling, and sample introduction. Common applications and analytical techniques will be covered as well, giving a comprehensive overview from air sampling to analysis.<h4>Key Learnings:&nbsp;</h4><ul><li>Learn how to choose the right air sampling approach by understanding the strengths and limitations of whole air vs. sorbent techniques</li><li>Learn how proper handling - from cleaning to sample introduction - directly impacts data quality and analytical outcomes</li></ul>

RESTEK: Air Sampling Media Selection and Analysis

Air Sampling Media Selection and Analysis

This presentation will give an overview of the selection of air sampling media, covering both whole air and sorbent sampling techniques. 

LCMS webinars focusing on Gas Generators - page 1