Toward Accurate Estimation of Extractable Organic Fluorine by Analysis of Fluoride Contamination in Extracts Using Gas Chromatography

Propionic Acid Outperforms Formic and Acetic Acid in MS Sensitivity for High-Flow Reversed-Phase LC-MS Bottom-Up Proteomics

<p><strong>In the week of August 31, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Technology Networks: Modern Methods for Faster Microbial Analysis</strong></h5><ul><li>Tu, 1.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6454">Registration</a></li></ul><p>Struggling to choose the right technique for microbial testing? Learn how MALDI-TOF, FTIR, and automated DNA/RNA electrophoresis accelerate identification.</p><h5><strong>2. Phenomenex: Addressing LC Method Optimization - Scaling For Efficiency, Throughput And Reproducibility</strong></h5><ul><li>We, 2.9.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6458">Registration</a></li></ul><p>Join this webinar on LC method optimization and scaling. Learn how column dimensions, particle morphology, and sample loading strategies maximize throughput and reproducibility.</p><h5><strong>3. Thermo Fisher Scientific: Proteoform Studio software, top down made simple</strong></h5><ul><li>We, 2.9.2026 14:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6459">Registration</a></li></ul><p>Learn how Thermo Scientific Proteoform Studio software simplifies top-down MS and intact protein analysis through integrated workflows, interactive deconvolution, and reporting.</p><h5><strong>4. Agilent Technologies: Targeted Hybridization Capture for Antimicrobial Resistance Surveillance in Complex Environmental Samples</strong></h5><ul><li>We, 2.9.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6455">Registration</a></li></ul><p>Discover how Agilent SureSelect hybrid capture enhances antimicrobial resistance gene detection and characterization in complex environmental samples compared with shotgun NGS.</p><h5><strong>5. Thermo Fisher Scientific: Ask the Expert: What to expect from the new Thermo Scientific™ Orbitrap™ Excedion™ Hybrid mass spectrometers</strong></h5><ul><li>Th, 3.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6466">Registration</a></li></ul><p>Discover the new Orbitrap Excedion Hybrid Mass Spectrometer and learn how enhanced dynamic range, robust performance, and an upgradeable design support advanced HRAM workflows.</p><h5><strong>6. Waters Corporation: Informatics series #34 Ready for Self-Documenting Chromatography?</strong></h5><ul><li>Th, 3.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6426">Registration</a></li></ul><p>Speed up root cause analysis with self-documenting LC and Empower software in this 30-minute Waters coffee break.</p><h5><strong>7. SciY/Mestrelab Research: From Legacy Workflows to Paperless Labs: Track Every Sample, Process, and Decision</strong></h5><ul><li>Th, 3.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6425">Registration</a></li></ul><p>Transform your lab from paper to digital. Learn how WebLab and LIMS workflows automate sample tracking and support laboratory compliance.</p><h5><strong>8. SelectScience: ADC characterization in one native LC-MS workflow</strong></h5><ul><li>Fr, 4.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6460">Registration</a></li></ul><p>Simplify ADC characterization with native RP-LC-MS using Biozen® columns to determine DAR, proteoforms, and positional isomers without buffer exchange.</p>

Webinars LabRulezLCMS Week 36/2026

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<div><h4><strong>Navigating Challenges and Opportunities for Environmental Testing Labs Under the Revised EU Water Framework Directive</strong></h4><p><strong>The European Commission’s proposed updates to the Water Framework, Groundwater, and Environmental Quality Standards Directives are bringing new responsibilities and opportunities for environmental testing labs. With expanded pollutant lists - including PFAS, pharmaceuticals, and pesticide metabolites - and stricter monitoring and reporting requirements, the landscape of water analysis is rapidly evolving.</strong></p><p>Join the 4th Waters Environmental Webinar Series to explore how your lab can navigate these challenges and turn regulatory change into opportunity.</p><p>Register for free and partner with us to shape the future of European water quality.</p><h5><strong>Why Attend</strong></h5><p>Stay ahead of new EU regulatory demands with insights from leading experts. Gain practical guidance, share experiences with peers, and prepare your lab for the next generation of water quality standards.</p><h5><strong>Highlights</strong></h5><ul><li>New pollutant categories and analytical challenges</li><li>Updates to monitoring protocols and reporting</li><li>Innovative methods to meet revised Environmental Quality Standards</li><li>Strategic guidance for compliance and adaptation</li></ul><p><strong>Lead the change in water analysis—stay ahead, stay compliant, and make a real impact.</strong></p><h4><strong>EPISODE 6: Blue Thursdays 2026 – The Best Of</strong></h4><p>In this final session, we’ll look back at the most important things we’ve learned throughout the Blue Thursday series. We’ll explore the big trends we’re seeing, the smart tools scientists use to study the environment, and what exciting developments will be coming next.</p><blockquote><p><strong>Speaker:</strong> Claudia Rathmann (Principal F&amp;E Market Development Manager, Waters Corporation)</p><p>Experienced and passionate analytical science professional with over 20 years of technical and strategic expertise in food and environmental applications. Currently serving as Principal Market Development Manager at Waters Corporation, Claudia specializes in connecting customers with product management to deliver innovative solutions for complex analytical challenges. With a strong scientific foundation and a proven track record in both technical and marketing roles, Claudia bridges the gap between customer needs and product innovation across the EMEA region.</p><p><strong>Speaker: </strong>Janitha De-Alwis (JD) (Principal F&amp;E Market Development Manager, Waters Corporation)</p><p>Janitha De-Alwis (known as JD) is an applications chemist in the European demo lab, based in Wilmslow, UK. His main role focuses on application development work for the food and environmental sector. JD takes great pride in speaking to, and advising, many food and environmental customers. His position requires him to be reactive and proactive to the changes in the food industry, such as changing regulations, topical issues and food safety risks.</p></blockquote></div>

Blue Thursdays 2026 – The Best Of

In this final session, we’ll look back at the most important things we’ve learned throughout the Blue Thursday series.

<p><strong>Mass spectrometry has become a cornerstone technology across the 'omics' sciences, enabling researchers to characterise complex biological systems with unprecedented depth and confidence. As advances in instrumentation, separation science, ion mobility, tandem mass spectrometry, and computational data analysis continue to evolve, laboratories can achieve broader molecular coverage and more meaningful biological insights.</strong></p><p>This webinar explores the latest innovations shaping modern mass spectrometry workflows and examines how these technologies are advancing applications across proteomics, metabolomics, lipidomics, spatial omics, and related fields. Attendees will gain practical insight into how complementary mass spectrometry approaches are improving analytical performance, supporting systems-level biological understanding, and driving progress in biomarker discovery, disease research, and precision health.</p><h4><strong>Key Learning Objectives:</strong></h4><ul><li>Explain why mass spectrometry is a foundational technology across multiple 'omics' disciplines</li><li>Describe recent advances in mass spectrometry instrumentation, separation science, ion mobility, and data analysis</li><li>Understand how integrated mass spectrometry workflows are enabling systems-level insights into biological function</li><li>Recognise the impact of mass spectrometry innovations on disease research, biomarker discovery, and precision health</li></ul><blockquote><p><strong>Presenter:</strong> &nbsp;James McCullagh, PhD (Professor of Biological Chemistry, University of Oxford)</p><p>&nbsp;James McCullagh is a professor of biological chemistry and director of the Mass Spectrometry Research Facility at the University of Oxford. His research focuses on understanding the function of small molecules in complex biochemical systems with applications at the interface between chemistry, biology and medicine.&nbsp;</p></blockquote><blockquote><p><strong>Presenter:</strong> Vladimir Kardelis, PhD (Technical Product Manager, PerkinElmer)</p><p>&nbsp;Vladimir Kardelis is the Technical Product Manager for LC and LC/MS solutions at PerkinElmer. Since joining the company in 2019 as a Software Quality Assurance Engineer, he has progressed through an Application Scientist role to lead product development for LC/MS solutions. His work focuses on evaluating the QSight system’s detection limits and robustness across complex environmental and food samples, helping advance reliable LC/MS performance in real-world laboratory settings.&nbsp;</p></blockquote>

Technology Networks: Tech Spotlight - Mass Spectrometry 2026

Tech Spotlight: Mass Spectrometry 2026

Discover 2026 mass spectrometry innovations across omics disciplines. Learn how advances in separation, ion mobility, and data analysis drive precision health

<p><strong>The objective of this webinar is to demonstrate how the ZenoTOF 8600 system enables advanced, reliable, and high-throughput analysis for food safety and environmental testing.</strong></p><h4><strong>Participants will gain an understanding of how to:</strong></h4><ul><li>Achieve ultra-sensitive quantitation and confident identification of contaminants in complex matrices</li><li>Apply high-resolution workflows for quantitation and screening applications</li><li>Improve data quality, throughput, and regulatory compliance in routine laboratories</li><li>Leverage the capabilities of the ZenoTOF 8600 system to address emerging analytical challenges such as trace-level contaminants, unknown screening, and large multi-residue panels</li></ul><h4><strong>Key learning points</strong></h4><p>Participants will learn how to:</p><ul><li>Leverage ZenoTOF 8600 system capabilities</li><li>Perform advanced screening and quantitation workflows</li><li>Optimize workflows for food and environmental samples</li><li>Improve data quality and confidence</li><li>Enhance laboratory productivity</li><li>Address emerging analytical challenges: Ultra-trace detection (ppt levels) and non-target screening, and retrospective data analysis</li></ul><h4><strong>Who should attend</strong></h4><p>This webinar is designed for professionals involved in food safety and environmental analysis, including:</p><ul><li>Analytical scientists and chemists</li><li>Working with LC-MS/MS or high-resolution MS in routine or research laboratories</li><li>Laboratory managers and supervisors</li><li>Looking to improve lab efficiency, throughput, and analytical capabilities</li><li>QA/QC professionals</li><li>Responsible for ensuring data quality, compliance, and regulatory standards</li><li>Food safety specialists</li><li>Involved in testing for pesticides, mycotoxins, veterinary drugs, and contaminants</li><li>Environmental analysts</li><li>Focused on monitoring PFAS, pharmaceuticals, pollutants, and emerging contaminants</li><li>Contract testing laboratories (CROs)</li><li>Seeking high-throughput, multi-residue screening capabilities</li><li>Researchers and method developers</li><li>Interested in advanced HRMS workflows and non-target screening.</li></ul><p><i>We will send you a recording of the event</i></p><blockquote><p><strong>Speaker: </strong>Dr. Jianru Stahl-Zeng (Senior Market Development Manager, SCIEX)</p><p>Jianru has been part of SCIEX since 2001. She initially was part of the application support team and covered not only proteomics, but also small molecules applications. Jianru moved to technical marketing and focused on food and environmental applications. Since 2018 she has been managing the EMEA technical marketing team and projects. Jianru is also the Global Technical Leader for food and environmental applications. On January 2026, she took the role of Senior Market Development Manager, FEF, EMEAI.</p></blockquote>

SCIEX: Tackling emerging contaminants in food and water using the ZenoTOF 8600 system

Tackling emerging contaminants in food and water using the ZenoTOF 8600 system

Master emerging contaminant analysis in food and water. Discover how the SCIEX ZenoTOF 8600 delivers ppt sensitivity, screening, and high throughput.

SCIEX ZenoTOF 8600: Emerging Contaminants in Food & Water

<div><p><strong>Rapid microbial analysis is essential for maintaining product quality, ensuring safety, and supporting efficient laboratory workflows, yet selecting the most appropriate analytical approach can be challenging.</strong></p><p>This educational webinar explores three complementary methods—matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) for microbial identification, Fourier transform infrared (FTIR) spectroscopy for microbial strain typing, and automated DNA/RNA electrophoresis for genetic analysis.</p><p>Through practical examples and application-focused discussion, attendees will gain a clearer understanding of each technique's strengths, limitations, and ideal use cases, helping them make more informed decisions when designing or optimizing microbial testing workflows.</p><p><strong>Attend this webinar to:</strong></p><ul><li>Understand how MALDI-TOF MS, FTIR, and automated DNA/RNA electrophoresis address different microbial analysis challenges</li><li>Learn how these three methods can support faster and more efficient microbial testing workflows</li><li>Evaluate which analytical approach is best suited to specific microbial testing applications and laboratory objectives</li><li>Apply practical considerations when implementing microbial identification, bacterial classification, or genetic analysis techniques in routine testing</li></ul><blockquote><p><strong>Presenter:</strong> Kaoru Nakagawa (Assistant Manager, Application Specialist (MALDI), Shimadzu Corporation)</p><p>Kaoru Nakagawa joined Shimadzu Corporation in 2008. She began her career at the Koichi Tanaka Mass Spectrometry Research Laboratory, where she developed highly sensitive glycan analysis methods using MALDI-MS with liquid-matrix-based on-plate labeling. Kaoru later moved to a customer-facing role, supporting applications such as, MALDI-MS imaging technologies, including on-tissue chemical derivatization. Today, her work focuses on developing rapid, practical methods for microbial identification using MALDI. Guided by Shimadzu’s corporate philosophy, “Contributing to society through science and technology,” she is dedicated to advancing mass spectrometry technologies that help address real-world scientific challenges.</p></blockquote><blockquote><p><strong>Presenter: </strong>Nozomi Maeshima (Assistant Manager, Application Specialist (Life Science), Shimadzu Corporation)</p><p>Nozomi Maeshima is an applications scientist at Shimadzu, where she has been involved in LC-MS application development in the life sciences field and in genetic analysis applications. She also leads promotional and marketing activities and supports customer inquiries. During university, she studied chemical biology and investigated the mechanisms of enzymes involved in biosynthetic processes. Nozomi brings a combination of research experience and applications expertise to help laboratories identify practical solutions for their analytical needs.</p></blockquote><blockquote><p><strong>Presenter:</strong> Xu Yan ( Assistant Manager, Application Specialist (FTIR), Shimadzu Corporation)</p><p>Xu Yan is an application chemist at Shimadzu Corporation with five years of experience developing FTIR applications for microbiology, environmental analysis, and GX-related fields. His work focuses on advancing practical FTIR applications and has gained extensive experience in method development and real-world implementation. In this session, Xu will present insights into the use of FTIR for microbiological analysis, including strain typing and related applications.</p></blockquote></div>

Technology Networks: Modern Methods for Faster Microbial Analysis

Modern Methods for Faster Microbial Analysis

Explore modern microbial analysis methods. Learn how MALDI-TOF MS, FTIR, and automated electrophoresis streamline identification, strain typing, and genetics

Modern Microbial Analysis: MALDI-TOF, FTIR & Electrophoresis

<p><strong>Achieving comprehensive antibody-drug conjugate (ADC) characterization no longer requires complex multi-step workflows. Advances in native LC-MS are creating new opportunities to simplify ADC analysis while maintaining the depth of information needed to support development decisions.</strong></p><p>In this SelectScience® TechTalk, Roxana Eggleston-Rangel, Senior Applications Scientist at Phenomenex, will showcase how Biozen® Native RP-1 and RP-5 columns enable direct drug-to-antibody ratio (DAR) analysis through a streamlined, MS-compatible native reverse-phase liquid chromatography-mass spectrometry (RP-LC-MS) workflow.</p><p>Learn how this approach supports DAR determination, proteoform characterization, and positional isomer resolution without fraction collection or buffer exchange while maintaining native conditions.</p><p>Using case studies featuring the approved ADC therapies Enhertu®, Padcev®, Polivy®, and Adcetris®, Eggleston-Rangel will demonstrate how this workflow can be applied across a range of ADC modalities and payload chemistries. In just 20 minutes, discover how the same approach can support both high-resolution mass spectrometry and routine UV-based DAR monitoring, bringing greater efficiency and confidence to ADC characterization.</p><h5><strong>Certificate of attendance</strong></h5><p>If you attend the live TechTalk, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes. If you view the on-demand TechTalk, you can request a certificate of attendance by emailing editor@selectscience.net.</p><h5><strong>TechTalk details</strong></h5><ul><li>Cost: Free to attend</li><li>Location: Online</li><li>Duration: 20 minutes</li></ul><p>Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on-demand recording once it becomes available.</p><h5><strong>Who should attend?</strong></h5><p><strong>This event is perfect for:</strong></p><ul><li>Pharmaceutical and biopharmaceutical characterization scientists</li><li>Analytical development managers and directors overseeing LC-MS workflows</li><li>Researchers developing methods for ADC characterization, drug-to-antibody ratio (DAR) analysis, and isomer identification</li></ul><h5><strong>What will this webinar cover?</strong></h5><ul><li>How native RP chromatography can be used for streamlined ADC DAR characterization and intact mass analysis.</li><li>Best practices for selecting Biozen® Native RP columns based on ADC properties and analytical goals.</li><li>How a single workflow can provide DAR determination, proteoform characterization, and positional isomer information.</li><li>Real-world examples demonstrating how native RP-LC-MS can improve efficiency while reducing sample preparation complexity.</li></ul><h5><strong>Join the TechTalk to get answers to these questions:</strong></h5><ul><li>How can native RP-LC-MS simplify comprehensive ADC characterization workflows?</li><li>How do Biozen® Native RP-1 and RP-5 columns enable direct intact ADC analysis?</li><li>How is drug-to-antibody ratio (DAR) accurately determined under native conditions?</li><li>How can native RP-LC-MS resolve proteoforms and positional isomers in ADCs?</li><li>What insights were gained from case studies on Enhertu®, Padcev®, Polivy®, and Adcetris®?</li></ul><blockquote><p><strong>Speaker:</strong> Roxana Eggleston-Rangel (Senior Application Scientist, Phenomenex)</p><p>Roxana Eggleston-Rangel is a Senior Applications Scientist specializing in biopharmaceutical characterization workflows, with expertise in LC-MS, native chromatography, antibody-drug conjugates (ADCs), monoclonal antibodies, and protein biotherapeutics. She develops and evaluates analytical methods for critical quality attributes, including drug-to-antibody ratio (DAR), oxidation, isomerization, glycation, and fragmentation. Her work focuses on advancing innovative chromatographic and mass spectrometry solutions, generating application data, technical publications, and scientific content that help researchers improve characterization of complex biologics and next-generation therapeutics.</p></blockquote>

Phenomenex: TechTalk - ADC characterization in one native LC-MS workflow

ADC characterization in one native LC-MS workflow

Simplify ADC characterization with Phenomenex Biozen® Native RP columns. Learn direct DAR determination and proteoform profiling in one LC-MS workflow

Native LC-MS ADC Characterization: Phenomenex Biozen Columns

<p><strong>Nitrosamine impurities continue to challenge pharmaceutical manufacturers as global regulatory requirements become more stringent. This webinar examines the analytical factors that drive successful nitrosamine and NDSRI testing, with a focus on LC/MS performance and column chemistry selection. Learn how triple quadrupole LC/MS delivers ultra‑trace sensitivity at low‑ng levels, how column chemistries (RP, HILIC, and mixed‑mode) influence separation and matrix interference, and how to optimize sample preparation and chromatography for complex drug matrices. Real‑world method development examples and regulatory perspectives from EMA, FDA, and Health Canada will round out this practical, application‑focused session.</strong></p><blockquote><p><strong>Presenter:</strong> Chander Mani&nbsp;</p><p>Chander Mani, currently a Field Technical Specialist for LC and GPC Columns, is an expert on nitrosamine workflow. He is Agilent’s Application Specialist, involved extensively in Nitrosamine method development work. He authored many application notes and ASMS posters on this subject and contributed immensely during discussions about nitrosamines in different platforms.</p></blockquote>

Agilent Technologies: Nitrosamine Testing: What Makes the Difference?

Nitrosamine Testing: What Makes the Difference?

Optimize nitrosamine and NDSRI testing in pharma using triple quad LC/MS. Learn column chemistry selection and sample prep to meet FDA and EMA standards

Nitrosamine & NDSRI Testing: LC/MS & Column Selection

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Join our experts for an in-depth look at the new Thermo Scientific™ Orbitrap™ Excedion™ Hybrid Mass Spectrometer—a next-generation HRAM platform designed to help laboratories confidently tackle today's analytical challenges while remaining ready for tomorrow's discoveries.</strong></p><p>Whether you're working in metabolomics, drug metabolism, environmental and food safety research, proteomics, or bioanalysis, the Orbitrap Excedion MS delivers the sensitivity, dynamic range, and robustness needed to detect more low-abundance compounds, improve confidence in your results, and maximize productivity. Learn how Full Scan Enhanced Dynamic Range (eDR) technology enables deeper sample coverage by revealing low-level analytes that conventional full-scan methods may miss, while maintaining outstanding quantitative performance.</p><p>This session will also explore how the Orbitrap Excedion platform is purpose-built for long-term value. With in-lab upgrade paths to the Orbitrap Excedion Pro MS, laboratories can expand capabilities as research needs evolve—protecting their investment without replacing their instrument. You'll also discover how a redesigned front-end, robust ion source, and simplified maintenance contribute to reliable, reproducible performance and greater uptime for busy laboratories.</p><p>Bring your questions and hear directly from our product experts about the innovations that are helping researchers generate more confident results today while preparing for the analytical challenges of tomorrow.</p><h4><strong>Who should attend?</strong></h4><ul><li>Scientists and laboratory managers seeking greater sensitivity, dynamic range, and confidence in HRAM mass spectrometry workflows.</li><li>Researchers working in metabolomics, DMPK, environmental and food safety, proteomics, bioanalysis, or other complex small-molecule applications.</li><li>Existing Orbitrap users and laboratories planning future instrument investments who want to understand the benefits of a scalable, upgradeable platform.</li></ul><h4><strong>What you can expect to learn</strong></h4><ul><li>How Full Scan Enhanced Dynamic Range (eDR) technology improves detection of low-abundance compounds and expands analytical coverage in complex samples.</li><li>How the Orbitrap Excedion MS delivers robust, reproducible performance with improved uptime, simplified operation, and reliable quantitative results.</li><li>How the platform's in-lab upgrade path enables your laboratory to add new capabilities as your research evolves, protecting your investment and future-proofing your workflows.</li></ul><blockquote><p><strong>Presenter: </strong>Maciej Bromirski (Sr. Product Marketing Manager, Thermo Fisher Scientific)</p><p>Maciej Bromirski has over 25 years of experience in mass spectrometry starting as an undergraduate student with late Prof. Ken Standing at the Physics Department at University of Manitoba in Winnipeg, Canada. Upon completion of his graduate studies on IR &amp; UV vacuum MALDI Q-TOF prototype MS with first oral presentation at ASMS and publications starting in 1999, Maciej undertook various roles and responsibilities with different Mass Spectrometry vendors. Since 2010 to present-day, Maciej has been fully dedicated to new product introductions and marketing developments of Q Exactive series, Orbitrap Exploris and more recently Orbitrap Excedion series MS with Thermo Fisher Scientific.</p><p><strong>Presenter: </strong>Claire Dauly (Senior Product Manager, Thermo Fisher Scientific)</p></blockquote></div></div></div>

Thermo Fisher Scientific: Ask the Expert: What to expect from the new Thermo Scientific™ Orbitrap™ Excedion™ Hybrid mass spectrometers

Ask the Expert: What to expect from the new Thermo Scientific™ Orbitrap™ Excedion™ Hybrid mass spectrometers

Explore the Orbitrap Excedion MS, featuring enhanced dynamic range, robust HRAM performance and an upgrade path to the Excedion Pro platform.

Thermo Scientific Orbitrap Excedion Hybrid mass spectrometer

<p><strong>Analytical Strategies for GLP-1 Therapeutics: Advancing Impurity Profiling with LC-UV/MS and High Resolution MS&nbsp;</strong></p><p>Glucagon-like peptide-1 (GLP-1) receptor agonists have transformed the treatment of type 2 diabetes and obesity, while increasing molecular complexity has created new analytical challenges for pharmaceutical scientists. Sequence modifications, fatty acid conjugation, and emerging multi-agonist designs require robust analytical strategies capable of detecting, characterizing, and monitoring impurities throughout development and manufacturing to ensure product quality, safety, and efficacy.</p><h4><strong>Why you should attend</strong></h4><p>This webinar will showcase complementary LC-MS approaches for the characterization and impurity profiling of GLP-1 therapeutics.</p><p>Part 1 will highlight the use of LC-UV/MS workflows as a versatile toolbox for impurity analysis of exenatide. Case studies will demonstrate how orthogonal mass information can enhance impurity detection beyond UV-based analysis, while complementary chromatographic approaches, including reverse-phase liquid chromatography (RPLC) and hydrophilic interaction liquid chromatography (HILIC), improve impurity resolution and raw material screening. Applications for characterizing amino acid sequence variants, monitoring stability-indicating impurities, and supporting risk-based decision-making in peptide manufacturing environments will be discussed.</p><p>Part 2 will focus on advanced characterization of the tirzepatide using high resolution mass spectrometry (HRMS). Through forced degradation studies under oxidative stress conditions, HRMS will be used to confidently identify degradants and elucidate impurity pathways, providing detailed structural insights into sites of molecular vulnerability and degradation mechanisms. Case studies will demonstrate how HRMS supports comprehensive characterization of complex peptide therapeutics and helps establish the analytical methodologies needed to identify and control clinically relevant impurities.</p><h4><strong>Key Learning Objectives</strong></h4><ul><li>Apply LC-UV/MS workflows to characterize impurities, sequence variants, and stability-indicating degradants in GLP-1 therapeutics.</li><li>Leverage complementary RPLC and HILIC separations to improve impurity detection and analytical confidence.</li><li>Understand how HRMS enables detailed structural characterization of GLP-1 analogs and their impurities.U<br>se forced degradation studies and degradant identification to support stability assessment and impurity control strategies.</li></ul><h4><strong>Who should attend</strong></h4><p>This webinar is designed for analytical development, LC-MS, CMC, and QC scientists working in pharmaceutical and biotechnology organizations developing or manufacturing GLP-1 and other therapeutic peptides.</p><p>Don't miss it!</p><blockquote><p><strong>Presenter: </strong>Duanduan Han, Ph.D. (Senior Scientist, Waters Corporation)</p><p>Duanduan Han is a Senior Scientist at Waters Corporation in Milford, MA. She specializes in LC–MS method development and troubleshooting, impurity profiling, and raw material screening for biopharmaceutical products and new modalities, including GLP‑1 therapeutics, lipid nanoparticles, oligonucleotides, surfactants, and monoclonal antibodies.</p><p>She earned her PhD in Chemical Engineering from Texas A&amp;M University.</p></blockquote><blockquote><p><strong>Presenter: </strong>Christopher Henry (Senior Scientist, Waters Corporation)</p><p>Chris Henry is a Principal Scientist at Waters Corporation in Wilmslow, UK. He has worked at Waters for 13 years focusing on LC-MS and GC-MS method development across small molecule and large molecule workflows using high resolution mass spectrometry.</p></blockquote>

GLP‑1 Analogs: Enhancing Impurity Profiling with LC‑UV/MS Workflows

Profile impurities in GLP-1 therapeutics using LC-UV/MS and HRMS. Learn RPLC/HILIC separation and forced degradation analysis for exenatide and tirzepatide

GLP-1 Impurity Profiling: LC-UV/MS & HRMS Workflows

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Missed the International Symposium on Chromatography 2026? Explore our posters and talks now.</strong></p><h4><strong>LC-MS/MS determination of PFAS in wild Baltic grey seal plasma for the assessment of health and developmental parameters</strong></h4><p>Per- and polyfluoroalkyl substances (PFAS) are persistent environmental contaminants that require highly sensitive and selective analytical methods for reliable quantification in complex biological matrices. Wildlife plasma presents additional analytical challenges due to limited sample availability, high protein and lipid content, and the risk of background contamination, making robust method development essential for accurate exposure assessment.</p><p>Following an initial LC-MS/MS screening of 31 PFAS compounds in pooled grey seal pup plasma, 10 target analytes were selected for quantitative method development. This webinar will demonstrate how the analytical workflow was designed and optimized to achieve reliable PFAS quantification from only 50 µL of plasma, including streamlined sample preparation, implementation of a delay column to minimize instrument-derived PFAS background, chromatographic separation using a Thermo Scientific Hypersil GOLD C18 Selectivity column, and quantitative analysis by isotope dilution LC-MS/MS. The presentation will conclude with the application of the validated method to plasma samples from Baltic grey seal pups and adults collected in Estonia, demonstrating its suitability for wildlife biomonitoring and providing insights into age- and sex-dependent PFAS exposure patterns.</p><h5><strong>What attendees will learn</strong></h5><ul><li>How to develop an LC-MS/MS method for PFAS in a highly complex plasma matrix</li><li>How to work with very limited sample volumes using a streamlined preparation workflow</li><li>How targeted PFAS screening can be converted into a quantitative method</li><li>How delay columns and chromatographic choices can help manage PFAS background and interferences</li><li>How validated PFAS data can support wildlife biomonitoring and toxicokinetic assessment</li></ul><h5><strong>Who should attend</strong></h5><p>This webinar is intended for analytical chemists, LC-MS/MS users, environmental monitoring scientists, toxicology researchers, and anyone working on biomonitoring of PFAS or other persistent contaminants in challenging biological matrices.</p><p>Register now to learn how a robust LC-MS/MS approach can enable reliable PFAS quantification in complex wildlife plasma samples.</p><p><i>If you are unable to attend the live webinar, please register to automatically receive a link to the on-demand recording.&nbsp;</i></p><blockquote><p><strong>Presenter: </strong>Elīna Pasečnaja, PhD (Product Application Specialist, Thermo Fisher Scientific)</p><p>Elīna Pasečnaja, PhD, is a Life Sciences Applications Specialist specializing in chromatography and mass spectrometry. With a PhD in Analytical Chemistry from Latvijas Universitāte, she combines lab expertise with environmental research, analyzing chemical pollutants to advance wildlife conservation and human health.</p></blockquote></div></div></div>

Thermo Fisher Scientific: LC-MS/MS determination of PFAS in wild Baltic grey seal plasma for the assessment of health and developmental parameters

LC-MS/MS determination of PFAS in wild Baltic grey seal plasma for the assessment of health and developmental parameters

Quantify PFAS in complex plasma samples using LC-MS/MS. Learn how delay columns and Hypersil GOLD C18 enable reliable analysis from 50 µL of sample

PFAS Determination in Seal Plasma by LC-MS/MS

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Missed the International Symposium on Chromatography 2026? Explore our posters and talks now.</strong></p><h4><strong>Practical aspects and advantages of coupling ion exchange chromatography to mass spectrometry for biotherapeutic analysis</strong></h4><p>Based on Ken Cook’s ISC 2026 talk, this expanded webinar will explore the practical aspects and advantages of directly coupling ion exchange chromatography to high-resolution mass spectrometry for biotherapeutic analysis.</p><p>The session will highlight how pH gradient elution with volatile, low ionic strength buffers can improve the analysis of monoclonal antibodies, fusion proteins, and PMOs, while avoiding the need for fraction collection and desalting.</p><p>Attendees will also learn about the key method development considerations that influence performance, including buffer selection, pH control, and column choice.</p><p>The talk will further demonstrate how direct ion exchange-MS can deliver high sensitivity, clean deconvolution, impurity detection, and GLP-ready quantitation in a streamlined workflow.</p><h5><strong>Key learnings</strong></h5><ul><li>Understand the principles and practical setup of direct ion exchange-MS for biotherapeutic analysis.</li><li>Learn how volatile, low ionic strength buffers support pH gradient separations compatible with MS.</li><li>See how buffer and column selection affect separation quality, sensitivity, and reproducibility.</li><li>Learn how the workflow applies to mAbs, fusion proteins, and PMOs.</li><li>Understand how direct coupling can improve impurity detection, deconvolution, and quantitation in regulated workflows.</li></ul><h5><strong>Audience</strong></h5><p>This webinar is intended for scientists and analysts working in biopharmaceutical characterization, protein analytics, oligonucleotide therapeutics, method development, and regulated analytical environments. It will be especially relevant for those working on charge variant analysis, intact protein characterization, impurity profiling, and GLP-compliant workflows.</p><p><i>If you are unable to attend the live webinar, please register to automatically receive a link to the on-demand recording.&nbsp;</i></p><blockquote><p><strong>Presenter: </strong>Dr. Ken Cook (BioPharma Applications Support Expert, Thermo Fisher Scientific)</p><p>Moved to industry from a University lectureship in Biochemistry, University of Newcastle upon Tyne, following 7 years’ experience in academia. Now with over 35 years’ experience with Thermo Fisher Scientific using a wide range of analytical equipment and software. Publications range from metabolomics, proteomics to large biopharmaceutical drug analysis. Current job title is the European manager for the BioPharma expert support group. This involves the support of Bio-Pharmaceutical applications to characterise protein and oligonucleotide based bio-therapeutics. This involves ongoing collaborations with the Biopharmaceutical industry and academia. Characterization methods of Bio-therapeutics include, monoclonal antibodies, peptides, AAV analytical development, small and large RNA analysis including sequence mapping of mRNA by LC/HRMS.</p></blockquote></div></div></div>

Thermo Fisher Scientific: Practical aspects and advantages of coupling ion exchange chromatography to mass spectrometry for biotherapeutic analysis

Practical aspects and advantages of coupling ion exchange chromatography to mass spectrometry for biotherapeutic analysis

Learn direct ion exchange chromatography-mass spectrometry (IEX-MS) for biotherapeutics. Streamline mAb, fusion protein, and PMO analysis using pH gradients.

LCMS webinars focusing on LC/MS - page 1