Czech researchers from Charles University, Prague, led by Pavla Eliášová, have developed an advanced photocathode that helps convert the greenhouse gas carbon dioxide into pure ethanol using sunlight. The new technology solves a long-standing problem of material degradation in water, achieves record conversion efficiency, and opens the way toward sustainable production of green fuels.Converting carbon dioxide (CO2) into useful fuels using solar energy represents the holy grail of modern green chemistry. The device enabling this conversion is called a solar reactor. Its key element is a photocathode: a material that absorbs light and enables the chemical reaction. Cuprous oxide long appeared to be an ideal material because it is inexpensive, readily available, and excels at capturing solar rays. In practice, however, it faced a fundamental obstacle: in an aqueous environment under light, it transforms and degrades extremely rapidly—much like iron undergoing swift corrosion—and loses its functionality within just tens of minutes.The team from the Chemistry Section of the Faculty of Science, CU, led by Pavla Eliášová, in collaboration with Tomáš Hrbek from the Faculty of Mathematics and Physics, CU, resolved this issue by creating a unique "nano-sandwich". The scientists combined cuprous oxide with advanced two-dimensional materials called MXenes and, through precisely controlled heating, created an ultrathin layer of titanium dioxide on their surface. MXene modified in this way can rapidly drain electric charge from the cuprous oxide, thereby slowing down its decomposition. At the same time, it uses the charge further to convert carbon dioxide into liquid fuel."Surface-engineered MXene combined with cuprous oxide allowed us to unite the best of both materials. The copper base enables maximum utilization of light energy, while the conductive MXene framework ensures that the material remains active even after many hours of operation," explains research team leader Pavla Eliášová from the Chemistry Section of the Faculty of Science, Charles University.In laboratory tests, the new photocathode achieved a record solar-energy-to-ethanol conversion efficiency of 2,74 %. A crucial improvement is the formation of only a single product. While other systems often produce a mixture of byproducts, the material designed by the research team produces pure ethanol as its sole liquid product, which significantly simplifies its potential industrial application."This is a major step forward for us. On our laboratory scale, the system works very well and produces ethanol over many hours. In the next step, we want to further reinforce the stability of the entire photocathode and begin testing on a larger scale and under real daylight conditions," adds physical chemist Pavla Eliášová.The research was conducted within the international European project DESIRED (Horizon Europe), with support from the Charles University Research Centre (UNCE) and the L'Oréal-UNESCO For Women in Science program.<blockquote><h4>Article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/aenm.71469">Surface-Engineered Ti3C2Tx MXene/Cu2O Photocathodes for Highly Selective Photoelectrocatalytic CO2 Reduction to Ethanol</a></h4>Luis A. M. Carrascosa, Magdaléna Linková, Monika Remzová, Tomáš Hrbek, Pavla EliášováAdv. Energy Mater., 2026, 16, e71469<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/aenm.71469">https://doi.org/10.1002/aenm.71469</a><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>Cu2O is an inexpensive p-type semiconductor that promotes the photoelectrocatalytic CO2 reduction reaction (PEC CO2RR). While its low bandgap enables photoexcitation by visible light, long-term stability remains limited due to quick charge recombination and photocorrosion. Here, we enhanced charge separation and extraction by combining Cu2O with surface-engineered MXenes. In this novel architecture, TiO2 grows in situ on the surface of Ti3C2Tx and serves as a charge-transport layer, forming a junction with Cu2O. On the other side, the outer TiO2 surface exposed to the CO2-saturated electrolyte offers catalytically active sites for CO2 reduction. Acting as a central layer, the MXene conductive backbone provides an electronically continuous pathway for electron transport. In PEC CO2RR, the photocathode containing 50 wt.% of MXene and a balanced amount of TiO2 on the Ti3C2 surface outperformed the best Cu/CuxO-based systems operating in non-organic electrolytes reported in the literature. The FTO/Cu2O/ml-Ti3C2Tx-350-N2 photocathode reached 8.4&nbsp;µmol&nbsp;cm−2 h−1 ethanol production rate and 2.74% solar-to-ethanol efficiency after 2&nbsp;h. Moreover, pairing TiO2-MXene with Cu2O significantly stabilized the photocathode, which maintained 76% of the ethanol production rate after 6 h. Overall, our results establish surface-engineered Cu2O/TiO2-MXene heterostructures as a solid platform for highly selective, visible-light-driven ethanol production with significantly improved operational stability.

Researchers from Charles University, Prague, Have Developed a New Photocathode for Efficient Conversion of CO2 into Ethanol

News from LabRulezLCMS Library - Week 42, 2026

Autumn has already turned the leaves into vibrant shades, and with the end of the year approaching, we would like to thank you - before the first snowflakes arrive - for your trust, cooperation, and continued interest in our products and services.As a long-standing distributor of Thermo Scientific Finnpipette products, we know that the accuracy and reliability of laboratory results often begin with seemingly small details. Choosing the right pipette and tip is one of the first steps toward a successful analysis.That is why we have prepared an EXCLUSIVE offer to help you replenish your laboratory supplies at a more attractive price, while also thanking you for your continued cooperation and trust.<blockquote>EXCLUSIVE OFFER valid until the end of 2026<ul><li>10% off tips</li><li>10% off pipettes</li></ul>Enter the code “KAŠTANY” in your order or include it in your order e-mail.*For larger orders, an additional discount may be available.</blockquote><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/analytika_pipety_a_spicky_thermo_20c5943161.jpg" alt="analytika: Thermo Scientific Pipettes and Tips" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_analytika_pipety_a_spicky_thermo_20c5943161.jpg 146w," sizes="100vw" width="1500" height="1605"><h4>LIMITED OFFER WHILE STOCKS LAST</h4><h5>Everything ages. 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The main mission of the Faculty of Science is to create highly qualified experts in biology, chemistry, geography, geology and in other interdisciplinary fields. Its scientific and research effort aims to solve key problems concerned with the development of human society. Some of the priority long-term subjects are human health, the study of the function and prediction of the development of ecosystems and the biosphere, and the development of environmentally-friendly materials based on the utilization of renewable resources.

Přírodovědecká fakulta Univerzity Karlovy

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Analytika is a Czech company that offers and produces certified reference materials (CRM) and (ultra)pure chemicals for quality control and quality assurance in laboratories, including accredited laboratories.

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ANALYTIKA

Agilent Technologies

labroots

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SCIEX

This webinar will provide a practical overview of advanced data processing tools in MassHunter Quant for both LC and GC workflows. Participants will learn how to set up and manage outliers, apply AddIns and Actions such as blank subtraction, and use queries to efficiently review and filter quantitative results. The session will also cover key aspects of Report Methods, helping users generate clear and consistent reports for routine and advanced quantitative workflows.<blockquote>Presenter: Dr Susanne Soelter (Field Application Specialist LC/MS, Agilent Technologies)Susanne Soelter started her career as a product specialist for LC/MS in 2004. She has remained loyal to LC/MS since then. In her current position as a Field Application Specialist, she develops new methods in the Agilent laboratory in Waldbronn and supports customers on site.Susanne studied chemistry in Hamburg and received a doctorate degree in organic chemistry from the University of Hamburg.Presenter:&nbsp;Teresa Klink (Application Specialist LC/MS and GC/MS, Agilent Technologies)Teresa started at Agilent Technologies in 2022 and works in the Applied Markets area developing analytical methods for GC/MS and LC/MS. Prior to joining Agilent she worked for several years in a contract lab and an industry company. There, she focused on developing analytical methods using LC/MS and GC/MS to check food packaging materials and printing inks for their migration behaviour and their regulatory compliance for food contact.</blockquote>

Agilent Technologies: MassHunter Class 2.0: Smarter Workflows from Acquisition to Insight

Advanced Quantitative Data Processing with MassHunter Quant

This webinar will provide a practical overview of advanced data processing tools in MassHunter Quant for LC and GC workflows. 

Quantitative Data Processing with MassHunter Quant

PFAS testing laboratories are being asked to do more than ever before. As regulatory requirements evolve and target analyte lists expand, analysts across environmental, food, and materials testing laboratories must deliver reliable trace-level PFAS measurements in increasingly complex applications. In this seven-part mini webinar series, we explore a range of solutions for trace-level PFAS determination, including Feed Injection and large-volume injection techniques, automated sample preparation, direct injection workflows, SPE strategies, thermal desorption, and complementary LC/MS/MS and GC/MS approaches. Each webinar addresses a different aspect of PFAS analysis, providing practical insights into workflow design, method performance, and laboratory productivity.<h4>Session 3: Validated Method for PFAS Testing in Food, Including Meats</h4>Food laboratories face the challenge of detecting PFAS at low concentrations in complex food matrices and demanding analytical requirements. Join this webinar to discover a simplified workflow for analyzing 30 PFAS in food using QuEChERS extraction, Captiva EMR PFAS Food II clean up, and LC/TQ detection.In this mini webinar, discover how to:<ul><li>Analyse 30 PFAS across diverse food matrices</li><li>Simplify extraction and matrix cleanup</li><li>Use Captiva EMR PFAS Food II for effective sample preparation</li><li>Streamline analysis through direct injection</li><li>Achieve the sensitivity, accuracy and precision required for food testing</li></ul><blockquote>Presenter: Peter Kornas (Application specialist LC/MS, Agilent Technologies)Peter has more than 15 years of experience in the development and validation of analytical methods for the determination of pesticides, mycotoxins and contaminants using LC/MS/MS. Before joining Agilent as an LC/MS application specialist in 2018, he worked as an analytical chemist in the food industry. During this time, he was responsible for the development and validation of analytical methods and worked in close coordination with Regulatory Affairs to ensure compliance with the legal requirements of the LC/MS method portfolio.Presenter: Nassima Galloway (Business Development Manager Food &amp; Environmental, Agilent Technologies)Nassima Galloway BSc obtained her degree at Manchester University in Medical Biochemistry BSc. Her professional career began working with environmental laboratories within EMEA offering support on sample preparation solutions and helping laboratories to optimise their workflows throughout.She now holds the position of Business Development Manager for EMEAI within the chemistries supplies division of Agilent Technologies.Nassima works closely within the food &amp; environmental markets to promote the latest advancements in sample preparation techniques and workflow solutions for LC/MS and GC/MS.</blockquote>

Agilent Technologies: PFAS Mini webinar Series

Validated Method for PFAS Testing in Food, Including Meats

Validated workflow for 30 PFAS in food using QuEChERS, Captiva EMR PFAS Food II cleanup, direct injection, and LC/TQ detection.

Validated Method for PFAS Testing in Food

The increasing focus on ultrashort PFAS, particularly Trifluoroacetic Acid (TFA) and Difluoroacetic Acid (DFA), is creating new analytical challenges for laboratories worldwide. Reliable quantification at trace levels requires a holistic approach that combines regulatory awareness, robust sample preparation, contamination management, optimized chromatography, and sensitive detection.In this webinar, Phenomenex experts will discuss key regulatory drivers, SPE sorbent selection, official PFAS methods, contamination control strategies and the role of delay columns in achieving reliable PFAS measurements.SCIEX experts will present a complete workflow for TFA and DFA analysis demonstrating how advanced LC-MS/MS technology and workflow automation help laboratories achieve ultra-sensitive detection, high throughput, and confidence in TFA and DFA analysis across multiple matrices.&nbsp;<h5>Key Learning Points</h5><ul><li>Understand the regulatory landscape and analytical challenges driving PFAS monitoring, with a focus on food, environmental, and emerging ultrashort-chain PFAS applications.</li><li>Implement robust PFAS workflows through optimized SPE sample preparation, appropriate column selection, and contamination management strategies, including the use of delay columns to improve analytical performance.</li><li>Improve data confidence and laboratory productivity by applying best practices for PFAS identification, quantification, and workflow standardization.</li><li>Address the growing challenge of TFA and DFA analysis using highly sensitive, automated LC-MS/MS workflows that deliver reliable results across multiple matrices with minimal hands-on time.</li></ul><h5>Who should attend:</h5><ul><li>Environmental &amp; Drinking Water Laboratories</li><li>Food Testing &amp; Food Safety Laboratories</li><li>PFAS Analysts &amp; Method Development Scientists</li><li>SPE &amp; Sample Preparation Specialists</li><li>LC-MS/MS Users</li><li>Laboratory Managers &amp; Technical Leaders</li><li>Regulatory &amp; Compliance Professionals</li></ul><blockquote>Presenter: Luigi Margarucci, PhD (EMEA Seminar and Application Lead, Phenomenex)Luigi holds a PhD in Pharmaceutical Sciences and began his career at Phenomenex in 2015 as a Technical Sales Consultant. In 2017, he took on the role of Mass Spectrometry Specialist, followed by Chromatography Training Manager in 2020. Since 2021, he has served as Technical Manager for Italy.He gained extensive experience in chromatography coupled with mass spectrometry while working as a researcher and research fellow at the University of Salerno, collaborating with leading chromatography and mass spectrometry centers in Italy and across Europe, including Utrecht University (The Netherlands).To date, Luigi has authored 27 scientific publications and has written and delivered numerous seminars on analytical techniques such as HPLC, GC, and SPE.&nbsp;</blockquote><blockquote>Presenter: Jianru Stahl-Zeng (Senior Market Development Manager Food, Environmental and Forensics, SCIEX)Jianru has been part of SCIEX since 2001. She initially was part of the application Support team and covered not only proteomics but also small molecules applications. Jianru then moved to technical marketing and focused on Food and Environmental applications.Since 2018, she is managing the EMEAI technical marketing team and projects. Jianru is also the Global Technical Leader for Food and Environmental applications.&nbsp;</blockquote>

Phenomenex: Confidence in PFAS Data: Smarter Sample Prep, Contamination Control, Highly Sensitive and Robust MS

Confidence in PFAS Data: Smarter Sample Prep, Contamination Control, Highly Sensitive and Robust MS

Learn how Phenomenex and SCIEX enable robust PFAS analysis. Master SPE sample prep, contamination control, and LC-MS/MS testing for TFA and DFA

Ultrashort PFAS and TFA Analysis by LC MS MS

PFAS are ubiquitous and detectable at increasingly low concentrations, making sample preparation a critical source of potential contamination. Labware, filtration consumables, and water used for dilutions and blanks can introduce background PFAS, compromising data integrity.Join our experts in this SelectScience® webinar as they explore practical strategies to reduce PFAS contamination in sample preparation for both LC-MS and Total Organic Fluorine (TOF) analysis using combustion ion chromatography (CIC). You will learn how to identify contamination pathways, implement best practices, and select consumables validated for low PFAS background.Sartorius solutions — including Arium® ultrapure lab water systems, Minisart® syringe filters, and Optifit® pipette tips — will be highlighted along with independent testing from Claros Technologies and Novem Scientific demonstrating their performance in LC-MS and TOF workflows.<h5>Certificate of attendance</h5>If you attend the live webinar, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.If you view the on-demand webinar, you can request a certificate of attendance by emailing editor@selectscience.net.<h5>Webinar details</h5><ul><li>Cost: Free to attend</li><li>Location: Online</li><li>Duration: 60 minutes</li></ul>Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on‑demand recording once it becomes available.<h4>Who should attend?</h4>This event is perfect for:<div><ul><li>Analytical chemists</li><li>Analytical lab heads/managers</li><li>Lab managers</li><li>QA and QC managers</li><li>Environmental scientists</li><li>Research scientists</li><li>Environmental lab professionals</li><li>LC-MS/MS-based clinical research professionals</li></ul><h4>What will this webinar cover?</h4><ul><li>Key PFAS contamination pathways and mitigation strategies</li><li>LC-MS vs. CIC/TOF sample preparation considerations</li><li>Independent test results on Sartorius consumables</li><li>How to select and validate consumables</li><li>Practical PFAS quality control strategies</li></ul></div><blockquote>Speaker: Andrew Christianson (President and CEO, Novem Scientific)Andrew Christianson is the President and CEO of Novem Scientific, LLC. He graduated in 2004 from the University of Minnesota, Morris with a BA in Chemistry, emphasis in Biochemistry. He has been serving the scientific industry and solving analytical problems for over 15 years in service and sales of analytical equipment and applications. In addition to being involved in the local Minnesota Chromatography Forum, he is also a voting member on the ASTM D19 water committee.Novem Scientific was founded in August 2021 and specializes in Total Organic Fluorine (TOF) analysis. TOF gives a non-targeted view of the total PFAS contribution in a sample as a compound class, without distinguishing individual analytes. The TOF test has been reimagined with modern instrumentation and Novem is on the cutting edge of research and development in new methods and matrices for this new and demanding analysis space.</blockquote><blockquote>Speaker: Sandra Söderholm, Ph.D. (Application Development Scientist, Sartorius)Sandra Söderholm earned her Ph.D. in Biochemistry from the University of Helsinki in 2016. Before joining Sartorius as an Application Development Scientist in 2019, she worked as a post doc in the field of infection biology at the University of Basel in Switzerland. At Sartorius, she focuses on the development, optimization, and validation of liquid-handling applications, and works with new product innovation, where understanding the customers’ workflows and needs plays a central role.</blockquote><blockquote>Speaker: Dr. Zijie 'Beryl' Xia (Director of Analytical Laboratories, Claros Technologies)Dr. Zijie 'Beryl' Xia is Director of Analytical Laboratories at Claros Technologies Inc., a PFAS destruction company. Since joining Claros in 2020, she has established its ISO-accredited PFAS analytical laboratory. Together with her team, she has developed standard PFAS methods and continues to advance non-standard methods and matrices for novel PFAS analysis.</blockquote><blockquote>Speaker: Klaus Schöne (Scientist, Sartorius)Klaus Schöne is a scientist who has been working at Sartorius, a supplier to the life science industry, since 2005. His work focuses on customer applications and translating application needs into new product solutions, including separation products for laboratory use such as PFAS sample preparation. Further areas of his expertise include the clarification and purification of biomolecules using ultrafiltration and chromatography.</blockquote><blockquote>Speaker: Dr. Kunal Kureja (Product Manager, Sartorius)Dr. Kunal Kureja is a Product Manager at Sartorius AG, specializing in laboratory water technologies and analytical applications. He earned his Ph.D. in Analytical and Preparative Chemistry from the University of Kassel and has worked across academic, startup, and industrial settings. His expertise includes application development, technical communication, and cross‑functional project leadership, with a particular focus on PFAS‑related analytical challenges and contamination risks in laboratory workflows.</blockquote><blockquote>Moderator: Todd Beanlands (Science Editor, SelectScience)</blockquote>

SelectScience: Minimizing PFAS background contamination in sample preparation

Minimizing PFAS background contamination in sample preparation

Learn how to reduce PFAS background contamination during sample prep. Discover Sartorius solutions for clean LC-MS and combustion IC workflows

Minimizing PFAS Contamination in Sample Prep

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>Discover a fully automated LC-MS/MS workflow for rapid, sensitive quantitaion of TFA across multiple matrices.Trifluoroacetic acid (TFA) is an ultra-short-chain PFAS of growing concern due to its extreme persistence, high mobility, and widespread occurrence in environmental and drinking water sources. This webinar reviews the emerging regulatory attention and the analytical challenges associated with trace-level measurement, including background contamination, matrix effects, ion suppression, and confirmatory analysis.The webinar introduces a fully automated SCIEX LC-MS/MS workflow for rapid, sensitive quantitaion of TFA across multiplematrices, with the flexibility to incorporate DFA and TFMS into the same analytical approach.Validation data demonstrates excellent linearity, repeatability, accuracy, robustness, and matrix tolerance in drinking water, surface water, wastewater, mineral water, and a wide variety of food matrices. With 40 samples plus standards analyzed in less than four hours, the workflow supports high-throughput routine monitoring for environmental, food, regulatory, and contract testing laboratories.<h5>By attending this webinar you will be able to:</h5><ul><li>Implement strategies to minimize contamination and matrix effects during trifluoroacetic acid (TFA) analysis</li><li>Evaluate the benefits of automated internal standard addition and automated calibration preparation</li><li>Apply a high-throughput LC-MS/MS workflow capable of quantifying TFA down to 20 ng/L with confirmation by two MRM transitions</li><li>Understand how trifluoromethanesulfonic acid (TFMS) and difluoroacetic acid (DFA) can be incorporated into the same analytical workflow</li></ul><h5>Who should attend?</h5>This webinar is designed for laboratory professionals and decision-makers involved in ultra-short-chain PFAS analysis, particularly those working in environmental, drinking water, wastewater, PFAS, regulatory, and contract testing laboratories:<ul><li>Commercial laboratory managers, technical directors, and QA/validation specialists responsible for method implementation, data quality, ROI and regulatory readiness.</li><li>LC-MS/MS method developers, analytical chemists, and application scientists working on trace-level TFA, DFA, TFMS, or broader PFAS workflows.</li><li>Environmental scientists, researchers, and laboratory staff focused on emerging contaminants in drinking water, surface water, wastewater, mineral water, and other complex water matrices such as food.</li></ul><blockquote>Presenter: Carlos Bueno (Senior Aftermarket Workflow Specialist, Food, Environmental and Forensics, SCIEX EMEA)Carlos Bueno is a Senior Aftermarket Workflow Specialist for EMEA at SCIEX with more than 20 years of experience in chromatography and mass spectrometry. After earning his bachelor’s degree in chemistry in 2001 and spending four years at the Madrid Doping Control Laboratory, he built an extensive career focused on analytical application development for food safety and environmental testing markets. Since joining SCIEX in 2023, he has supported laboratories across EMEA in implementing advanced LC-MS/MS solutions and optimizing analytical workflows, and is currently leading SCIEX EMEA's PFAS initiative.</blockquote></div></div></div>

SCIEX: The TFA and DFA challenge solved: ultra-sensitive detection with end-to-end automation

The TFA and DFA challenge solved: ultra-sensitive detection with end-to-end automation

Learn how automated LC-MS/MS enables sensitive TFA, DFA, and TFMS analysis down to 20 ng/L in water and food matrices with high throughput

Automated LC-MS/MS Analysis of TFA and DFA

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>Accurate characterization of drug metabolites is critical to drug discovery and development, but labile metabolites and emerging peptide therapeutics can present significant analytical challenges. In-source fragmentation may obscure important small-molecule biotransformations, while complex peptide drugs require high sensitivity to detect and characterize low-abundance metabolites in biological matrices.Join experts from AbbVie and MIT (Massachusetts Institute of Technology) to explore how next-generation Orbitrap™ high-resolution accurate mass (HRAM) mass spectrometry can help address these challenges. Through applications involving labile small-molecule metabolites and semaglutide, the speakers will examine strategies for optimizing source conditions, balancing metabolite integrity with sensitivity, and extending HRAM workflows to support both metabolite identification and quantitative analysis.The webinar will also highlight cross-platform studies of Orbitrap mass spectrometers, providing practical insights into how advances in instrument design, acquisition strategies, and method optimization can improve confidence in drug metabolite characterization and quantification.<h5>Learning Objectives:</h5><ul><li>Understand key analytical challenges in characterizing labile small-molecule metabolites and complex peptide therapeutics, including in-source fragmentation and low-abundance metabolite detection.</li><li>Learn how source optimization and next-generation Orbitrap&nbsp;HRAM mass spectrometry can improve metabolite integrity, sensitivity, and confidence in characterization</li><li>Explore HRAM LC-MS strategies that integrate comprehensive metabolite identification with sensitive intact drug quantification across diverse drug metabolism studies.</li></ul><blockquote>Presenter: Alena Joignant, PhD (Senior Scientist, AbbVie)Alena Joignant is a Senior Scientist in AbbVie’s Biotransformation and Disposition group, where her work focuses on metabolite identification for First-in-Human and ADME studies. Her current collaboration with Thermo Fisher Scientific explores mass spectrometry approaches for improving the detection and characterization of labile small-molecule drug metabolites. She received her PhD from North Carolina State University, where she researched sampling innovations for IR-MALDESI mass spectrometry imaging and high-throughput screening.</blockquote><blockquote>Presenter: Aaron Lopes (Senior Research Engineer, MIT)Aaron Lopes is the core director for the bioanalytics platform at MIT, managing a for-service analytical lab which provides state-of-the-art resources for chromatography and mass spectrometry. Aaron has worked on GLP-1 receptor agonists for over a decade, developing many cGMP quality assays and DMPK bioanalytical assays for semaglutide and tirzepatide. Through collaborations with Novo Nordisk and Eli Lily, his efforts have aided in the successful commercialization of oral GLP-1 medications.&nbsp;</blockquote></div></div></div>

Labroots: Advancing Drug Metabolite Characterization with Next-Generation Orbitrap HRAM Mass Spectrometry

Advancing Drug Metabolite Characterization with Next-Generation Orbitrap HRAM Mass Spectrometry

Learn how Thermo Fisher Scientific Orbitrap HRAM LC-MS improves drug metabolite characterization and quantification for labile compounds and peptides

Orbitrap HRAM Drug Metabolite Analysis

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>High-resolution accurate mass (HRAM) mass spectrometry has transformed quantitative bioanalysis, opening new possibilities for challenging analytes that have historically pushed the limits of conventional approaches. Join Troy Voelker for a practical look at the evolution of HRAM mass spectrometry for quantitative bioanalysis and how advances in Orbitrap™ technology are helping address increasingly complex analytical challenges.Drawing on more than a decade of experience applying high-resolution mass spectrometry to quantitative workflows, Troy will trace the progression from early studies evaluating whether HRAM could deliver the speed, precision, specificity, and dynamic range required for quantitative analysis to its growing role in modern bioanalysis.The session explores oligonucleotide bioanalysis, including multiple charge states, nonspecific fragmentation, matrix interference, and demanding sensitivity requirements. Troy will share findings from an industry oligonucleotide ring trial and discuss how established methods provided a benchmark for evaluating the next generation of Orbitrap technology, featuring the new Thermo Scientific™ Orbitrap™ Excedion™ Hybrid Mass Spectrometer.Attendees will have the opportunity to participate in the live Q&amp;A following the presentation.<h5>Who should attend?</h5>Scientists and laboratory leaders developing quantitative bioanalytical methods using HRAM MS; researchers working with oligonucleotides and nucleic acid therapeutics; and bioanalytical scientists interested in sensitivity, specificity, and quantitative performance.<h5>What you can expect to learn</h5><ul><li>How HRAM MS has evolved for quantitative bioanalysis</li><li>Why charge-state behavior and fragment selection are critical for oligonucleotide LC-MS specificity</li><li>How hybridization sample preparation and HRAM detection can support sensitive workflows</li><li>How Orbitrap Excedion technology can extend sensitivity, speed, and dynamic range</li></ul><blockquote>Presenter: Min Du (Senior Manager, Pharma/BioPharma Applications, Thermo Fisher Scientific)Min Du is the Senior Manager of Pharma/Biopharma Applications for Chromatography and Mass Spectrometry at Thermo Fisher Scientific. With extensive expertise in analytical workflows, she leads teams developing cutting-edge LC-MS solutions. Her work focuses on bioanalysis challenges, RNA oligonucleotide characterization, and advancing therapeutic workflows.Presenter: Troy Voelker (Senior Director of Laboratory Operations, Aliri Bioanalysis)Troy Voelker is an accomplished bioanalytical scientist with more than a decade of experience advancing high-resolution mass spectrometry. His career spans pioneering quantitative HRMS applications to today’s cutting-edge oligonucleotide bioanalysis, with deep expertise in developing methods for complex therapeutics.Moderator: Breana Murphy (Regional Marketing Manager LSMS-North America, Thermo Fisher Scientific)</blockquote></div></div></div>

Thermo Fisher Scientific: The Groundbreakers Series: Pushing Boundaries 

Advancing Oligonucleotide Bioanalysis with High-Resolution Mass Spectrometry

Join this webinar for a practical look at the evolution of HRAM mass spectrometry for quantitative bioanalysis.

Oligonucleotide Bioanalysis with HRMS

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>Join our experts for an in-depth look at the new Thermo Scientific™ Orbitrap™ Tribrid™ Apex Mass Spectrometer, a flexible, high-performance platform engineered for greater speed, sensitivity, fragmentation flexibility, and performance across demanding analyses.Whether you’re working in proteomics and multiomics, structural biology, biopharmaceutical characterization, or small-molecule analysis, the Orbitrap Tribrid Apex MS combines high-resolution accurate-mass performance with advanced ion parallelization, flexible MSⁿ workflows, infrared-enabled fragmentation, and intelligent acquisition. Learn how these capabilities can help researchers gain deeper insight into complex samples, from identifying and quantifying low-level compounds to characterizing PTMs, protein complexes, and complex biotherapeutics.This session will also explore how the Orbitrap Tribrid Apex platform can be tailored to different scientific needs. Four application-focused editions for MultiOmics, Structural Biology, BioPharma, and Small Molecule research extend the core capabilities of Tribrid mass spectrometry with specialized functionality for different workflows. Our experts will discuss how these capabilities can be applied to real experimental challenges and answer your questions about the platform, applications, and workflows.&nbsp;<h5>Who should attend?</h5>Mass spectrometry scientists, researchers, and laboratory leaders working in small-molecule characterization and quantitation, proteomics and multiomics, structural biology, or biopharmaceutical characterization.<h5>What you can expect to learn</h5><ul><li>The speed, sensitivity, fragmentation flexibility, and ion parallelization available with the Orbitrap Tribrid Apex MS</li><li>The distinct capabilities of the Small Molecule, MultiOmics, Structural Biology, and BioPharma editions</li><li>Ways advanced fragmentation, intelligent acquisition, and flexible MSⁿ workflows can provide deeper structural and molecular insight</li><li>Where Native MS, Direct Mass Technology mode, IR-assisted fragmentation, and PTCR can add value</li></ul><blockquote>Presenter: Rafael Melani, PhD (Senior Manager, Product Management, Thermo Fisher Scientific)Dr. Rafael D. Melani is a Senior Product Manager for Orbitrap Tribrid Mass Spectrometers at Thermo Fisher Scientific. He earned his PhD in Biochemistry and has extensive expertise in top-down and bottom-up proteomics, native MS, mass spectrometry, and proteoform characterization.Presenter: Graeme McAlister (Principal Scientist, Research &amp; Development, Thermo Fisher Scientific)Graeme McAlister is a Principal Scientist at Thermo Fisher Scientific working on the Orbitrap Tribrid product line. He earned his PhD at the University of Wisconsin–Madison and completed postdoctoral research at Harvard Medical School, where he developed the SPS MS3 TMT workflow.Moderator: Breana Murphy (Regional Marketing Manager LSMS-North America, Thermo Fisher Scientific)</blockquote></div></div></div>

Ask the Expert: Explore the New Thermo Scientific™ Orbitrap™ Tribrid™ Apex Mass Spectrometer

Join our experts for an in-depth look at the new Thermo Scientific™ Orbitrap™ Tribrid™ Apex Mass Spectrometer

Thermo Scientific Orbitrap Tribrid Apex MS

This webinar provides a foundational overview of sample enrichment approaches and LC analysis workflows for oligonucleotides, DNA, and RNA-based therapeutic molecules.We will start by exploring the molecular structure and challenges associated with these molecules and learn about the various chromatographic techniques for their comprehensive characterization.The session will cover the practical approaches for sample preparation and selectivity optimization for gaining higher sensitivity and efficiency in LC-MS/MS methods. Attendees will gain insight into how the method development and optimization approaches can be applied across a variety of DNA and RNA-based molecules for solving the prevalent bioanalytical challenges.<h4>One webinar, two viewing options</h4><h5>Viewing Options</h5>Session 1<ul><li>Tuesday, October 27, 2026 Los Angeles: 10:00 AM PT | New York: 1:00 PM EST Mexico City: 12:00 PM CDT</li></ul>Session 2<ul><li>Wednesday, October 28, 2026 London: 9:00 AM GMT | Berlin: 10:00 AM CET&nbsp; Mumbai: 2:30 PM IST</li></ul><h4>Key Learning Points</h4><ul><li>Describe Nucleic Acids and Oligonucleotides, including their molecular structure, their production process, and how they are delivered as therapeutic medicines.&nbsp;</li><li>Define the ubiquitous challenges associated with these molecules and define the Critical Quality Attributes (CQAs) for mRNA and explain how they relate to product quality, safety, and performance.&nbsp;</li><li>Describe common sample enrichment approaches for these molecules.</li><li>Understand the typical workflow designs and their role in supporting downstream LC and LC-MS/MS analysis. &nbsp;</li></ul><h4>Who Should Attend</h4><ul><li>Any scientists and professionals working in biopharma, life sciences, CROs, CDMOs or analytical laboratories interested in learning about Oligonucleotides and Nucleic Acid based therapeutic analysis workflows as well as sample enrichment and sample preparation approaches. &nbsp;</li></ul><blockquote>Speaker: Namrata Saxena (Technical Manager, Phenomenex)&nbsp;Namrata Saxena is the Technical Manager for the Asia-Pacific region at Phenomenex and is part of the global technical team, she provides expert support for a wide range of chromatographic challenges particularly in the characterization of biotherapeutics and emerging cell and gene therapy modalities. Her role includes delivering technical training, hosting seminars and webinars, and contributing to scientific content development. Prior to joining Phenomenex, Namrata worked as a Product Specialist at Bischoff Chromatography GmbH in Germany where she gained extensive experience in stationary phase chemistry, column manufacturing and method development domains. Namrata is based in Sydney, Australia and can be reached through e-mail or phone.&nbsp;</blockquote>

Phenomenex: Fundamentals First Bio Series: Understanding Oligonucleotides & Nucleic Acid Based Bioanalytical Workflows

Understanding Oligonucleotides & Nucleic Acid Based Bioanalytical Workflows

Learn LC-MS/MS workflows and sample enrichment strategies for oligonucleotides and nucleic acid therapeutics in this Phenomenex technical webinar

Oligonucleotide LC-MS/MS Bioanalysis

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>The investigation of the spatially organized regulation of protein phosphorylation across whole tissue is critical to facilitate an accurate, comprehensive understanding of disease mechanisms and therapeutic effects. Here, we introduce Phos-MASP (micro-scaffold-assisted spatial phosphoproteomics), the first-ever spatial phosphoproteomics method enabling reproducible, in-depth mapping of phosphosites at the whole-tissue level. &nbsp;Uniquely, Phos-MASP also allows parallel profiling of both the proteome and phosphoproteome from the same tissue. &nbsp;Leveraging the robust, reproducible separation of OptiSpray and the ultra-sensitive quantification capabilities of the Orbitrap Astral, this workflow achieves exceptional mapping depth and accuracy. By applying Phos-MASP to an Alzheimer’s Disease model, we reliably mapped ~10,000 proteins and ~30,000 phosphosites, revealing disease-specific intra-brain distributions that offer unprecedented spatial insights into disease mechanisms and therapeutic interventions.<h5>Key learnings:</h5><ul><li>Understanding the fundamentals of Phos-MASP and its significance in spatial phosphoproteomics&nbsp;</li><li>Best practices for implementing Phos-MASP in research&nbsp;</li><li>How Phos-MASP enables parallel profiling of both the proteome and phosphoproteome from the same tissue&nbsp;</li><li>Insights into the robust, reproducible separation of Thermo Scientific OptiSpray ion source and the ultra-sensitive quantification capabilities of the Thermo Scientific Orbitrap Astral MS&nbsp;</li><li>Real-world applications of Phos-MASP in mapping disease-specific intra-brain distributions in Alzheimer's Disease models&nbsp;</li></ul><h5>Who should attend:</h5><ul><li>Researchers and professionals in the fields of proteomics and phosphoproteomics&nbsp;</li><li>Scientists interested in spatially organized regulation of protein phosphorylations&nbsp;</li><li>Individuals looking to expand their knowledge in disease mechanisms and therapeutic effects&nbsp;</li><li>Students and newcomers interested in advanced proteomics techniques&nbsp;</li><li>Anyone interested in staying updated with the latest advancements in spatial phosphoproteomics&nbsp;</li></ul>If you cannot attend the live webinar, please register anyway to automatically receive the link to the recording.<blockquote>Presenter: Jun Qu (Professor, Dept of Pharmaceutical Sciences, University at Buffalo, The State University of New York (SUNY))Jun Qu is a professor in the Department of Pharmaceutical Sciences of SUNY-Buffalo and the director of the Proteomics and Pharmaceutical Analysis Group in the New York Center of Excellence in Bioinformatics and Life Sciences. His research is directed toward the innovations in both global and targeted analysis of proteins, in the context of pharmaceutical and clinical investigations. His group is one of the international leaders in LC-MS-based study of biotherapeutics and drug targets in pre-clinical models, as well as MS1-based, large-cohort quantitative proteomics. He has &gt;160 peer reviewed publications and &gt;80 grants funded as PI or co-I.</blockquote></div></div></div>

Thermo Fisher Scientific: Whole-tissue, parallel mapping of 10,000 proteins and 30,000 phosphosites by integrating MASP with OptiSpray/Orbitrap Astral

Whole-tissue, parallel mapping of 10,000 proteins and 30,000 phosphosites by integrating MASP with OptiSpray/Orbitrap Astral

Jun Qu showcases workflow for spatial proteomics using Thermo Scientific OptiSpray ion source, cartridge column and the Thermo Scientific Orbitrap Astral MS.

LCMS webinars focusing on LC/MS - page 1