Post-translational modifications (PTMs) are where so much of biology’s complexity lives, but they are also some of the hardest molecular features to analyze with confidence. Phosphorylation, asymmetric dimethylarginine (ADMA), and O-GlcNAcylation (O-GlcNAc) often occur at low abundance, can be highly labile, and frequently require precise site localization to understand their biological meaning. This<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/tn_004377_ov_phosphorylation_ptm_etd_excedion_pro_tn004377_na_en_71f681655f.pdf"> technical note </a>shows how the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1958">Thermo Scientific Orbitrap Excedion Pro Hybrid Mass Spectrometer</a> helps address those challenges by combining fast, sensitive performance with complementary <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/7217">HCD and EThcD fragmentation</a> workflows.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Phosphorylation_ADMA_and_O_Glc_N_Ac_Analysis_on_the_Orbitrap_Excedion_Pro_Mass_Spectrometer_d24a5de98e.jpg" alt="Thermo Fisher Scientific: Phosphorylation, ADMA, and O-GlcNAc Analysis on the Orbitrap Excedion Pro Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Phosphorylation_ADMA_and_O_Glc_N_Ac_Analysis_on_the_Orbitrap_Excedion_Pro_Mass_Spectrometer_d24a5de98e.jpg 245w," sizes="100vw" width="1024" height="512">Using enriched PTM samples and automated data-dependent acquisition, the study demonstrates that the Orbitrap Excedion Pro MS can deliver both depth and confidence across multiple PTM classes. For phosphorylation analysis, the platform identified 5,892 unique phosphosites from IMAC-enriched samples and 2,941 unique phosphotyrosine sites after phosphotyrosine enrichment, highlighting strong performance for both broad and highly targeted signaling studies. Just as importantly, the data show that HCD and EThcD provide complementary value, with each fragmentation method contributing unique site identifications and helping resolve ambiguous assignments.The note also highlights the value of EThcD for more analytically demanding PTMs. In ADMA-enriched samples, EThcD delivered more ADMA peptide-spectrum matches and more unique modified peptides than HCD, supporting improved confidence in site characterization. For O-glycopeptides, the Orbitrap Excedion Pro MS uses an intelligent HCD-product-dependent-EThcD strategy that triggers EThcD only when oxonium ions are detected, improving productivity while preserving the fragmentation detail needed for confident glycosite localization.Overall, this technical note shows how Orbitrap Excedion Pro MS enables researchers to go deeper into PTM biology with greater sensitivity, better site confidence, and smarter acquisition. For scientists studying signaling, regulation, and disease mechanisms, it presents a powerful approach for expanding PTM coverage without compromising analytical rigor.<blockquote><h5><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/tn_004377_ov_phosphorylation_ptm_etd_excedion_pro_tn004377_na_en_71f681655f.pdf">Download the technical note</a></h5></blockquote>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#PTM #OrbitrapExcedionPro #glycosylation #phosphorylation

Phosphorylation, ADMA, and O-GlcNAc Analysis on the Orbitrap Excedion Pro Mass Spectrometer

The countdown is almost over. In just one week, the international chromatography community will meet in Prague for the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/events/644">35th International Symposium on Chromatography (ISC 2026)</a>, taking place from September 6–10, 2026. Whether your registration has been confirmed for months or you are still deciding whether to join, now is the time to finalize your plans. Here is what you need to know before ISC 2026 begins.<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/companies/314">ISC</a> is the oldest conference series dedicated to separation science, with symposia organized since 1956. This September, the Prague Congress Centre will welcome researchers, industry experts, instrument manufacturers, young scientists, and other specialists for five days of chromatography and separation science, covering everything from fundamental research to pharmaceutical, environmental, food, health, and omics applications.But before the scientific sessions begin, there are a few practical details worth checking.<h4>ISC officially starts on September 6 – but activities begin a day earlier</h4>The official dates for ISC 2026 are Sunday, September 6 through Thursday, September 10, but for some participants the conference starts already on Saturday, September 5.The first Short Courses are scheduled for Saturday (<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/6770">SC 1 – Modern HPLC Separation in Theory and Practice</a> and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7312">SC 2 – mzmine for LC-MS data analysis</a>), with additional courses continuing on Sunday morning and afternoon. If you have registered for a Short Course, make sure to check its exact date and starting time before arranging your journey to Prague.Sunday then marks the official opening of ISC 2026, with the Opening Ceremony, Award Ceremony, <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7361">plenary lectures</a>, and Welcome Reception introducing delegates to the week ahead.<h4>Haven’t registered yet? You can still join ISC 2026</h4>Missed the late-registration deadline? It is still possible to attend.Onsite registration has been available since August 26, 2026, giving last-minute participants another opportunity to join the symposium. Current onsite registration fees are:<ul><li>Industry: €1,150</li><li>Academic: €890</li><li>Student: €390</li><li>Short Courses: €270</li></ul>The Short Course fee covers participation in up to three Short Courses.One practical point for last-minute registration: bank-transfer payments closed on August 19, so only card payments are now accepted.Full registration includes access to oral and poster sessions, the exhibition, the Sunday Welcome Reception, scheduled lunches and coffee breaks, the electronic Book of Abstracts, and a Prague public transportation pass.<h4>Where is ISC 2026 and how do you get there?</h4>ISC 2026 will take place at the:Prague Congress Centre<ul><li>5. května 65</li><li>140 21 Prague 4</li><li>Czech Republic</li></ul>The venue is particularly easy to reach by public transport. It is located directly on Prague’s Metro Line C at Vyšehrad station, just around five minutes by metro from Muzeum station in the city centre.The Prague Congress Centre brings the lecture halls, exhibition spaces, meeting rooms, and other conference facilities together in one venue, making it easy to move between scientific sessions, posters, industry activities, and the exhibition throughout the day.And since full conference registration includes public transportation in Prague, getting around the city during ISC should be straightforward.<h4>When can you pick up your conference materials?</h4>The registration desk will already be open during the Short Courses and will remain available throughout the symposium.Registration opening hours:<ul><li>Saturday, September 5: 8:30–17:00</li><li>Sunday, September 6: 7:30–19:00</li><li>Monday, September 7: 7:30–18:00</li><li>Tuesday, September 8: 7:30–19:00</li><li>Wednesday, September 9: 8:00–18:00</li><li>Thursday, September 10: 8:30–14:30</li></ul>If you are arriving in Prague on Sunday, allowing some extra time for registration before the Opening Ceremony will make the start of the conference considerably more relaxed.<h4>Now is the time to build your personal ISC program</h4>With several parallel sessions running throughout the week, trying to decide where to go only after arriving at the venue may mean missing something important.The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7477">main scientific program</a> is organized around three broad areas:<ul><li>Fundamentals</li><li>Bioanalysis and omics applications</li><li>Hyphenated techniques</li></ul>These are complemented by <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7280">Tutorials </a>+ Young Speakers, plenary and invited lectures, poster sessions, the international exhibition, vendor seminars, and industry-focused activities.Before leaving for Prague, take another look at the Interactive Program and mark the lectures, posters, and other activities that are most relevant to you. If you are presenting your own work, this is also the right time to double-check your assigned session, room, and presentation time.And don’t focus only on the oral program. Poster sessions and exhibition breaks are among the best opportunities to discuss new research directly with authors, meet instrument and technology specialists, and make new contacts.<h4>Don’t overlook the vendor seminars and industry program</h4>ISC 2026 is not limited to academic presentations. The conference also includes an extensive industry component, with activities covering current challenges in separation science and practical applications of new analytical technologies.During the lunchtime sessions, participants can attend <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7736">vendor seminars</a> presented by companies including Avantor, Shimadzu, Advanced Materials Technology, Restek, and Thermo Fisher Scientific. Topics range from stationary-phase selectivity and chromatographic modelling to HPLC and LC-MS column technologies and advanced characterization of biotherapeutics.The conference also includes dedicated <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7777">Industry Activities</a> from Monday through Wednesday, bringing together academic and industrial perspectives on topics relevant to analytical laboratories and the future of separation science. One of the discussions, for example, will examine how education in separation science can better reflect the skills required by modern industry, while another will focus on sustainability and the practical implementation of greener analytical workflows.On Wednesday, participants can also join the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7801">Publishing Workshop</a>, another activity worth adding to the schedule if scientific publishing is part of your work.<h4>Test your chromatography knowledge at the ISC Quiz</h4>Not every session needs to be completely serious.On Tuesday, September 8 from 18:30 to 19:30, ISC will host an interactive Chromatography Quiz, combining practical questions, chromatography fundamentals, unusual facts, and lighter challenges.There is no advance registration required. Any registered conference participant can join, but remember to bring a smartphone—the quiz uses live participation through a QR code.Results will be scored in real time, and prizes will be awarded to the top three participants.<h4>Start networking from the first evening</h4>The scientific program may be the main reason to attend ISC, but the conversations between sessions can be equally valuable.The first major networking opportunity comes immediately on Sunday.The Welcome Reception will take place on September 6 from 18:30 to 20:00 in the second-floor foyer of the Prague Congress Centre. It is open to registered participants and accompanying persons and includes a light buffet and drinks.As it takes place immediately after the opening program, it is an ideal opportunity to reconnect with colleagues, meet new contacts, and start conversations before the full parallel scientific program begins on Monday.Another social highlight will be the Gala Dinner on Wednesday, September 9 from 19:00 to midnight at the National House Vinohrady.The Gala Dinner requires a separate €100 ticket, is not included in the standard registration fee, and has a smart-casual dress code. Participants should also note that transportation to and from the venue is not organized by the conference.<h4>And perhaps leave a little time for Prague</h4>A conference schedule can fill up quickly, but ISC 2026 is taking place in one of Europe’s most walkable cities.If you find some free time between sessions, Vyšehrad is only about a 10-minute walk from the Prague Congress Centre and offers panoramic views across Prague and the Vltava River. It is an easy option for a short walk without travelling back into the historic city centre.See you at ISC 2026 in Prague!

ISC 2026 Starts in One Week: What You Need to Know

In the week of August 31, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>👉 Search and filter in the largest global database with over 5 500 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. Technology Networks: Modern Methods for Faster Microbial Analysis</h5><ul><li>Tu, 1.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6454">Registration</a></li></ul>Struggling to choose the right technique for microbial testing? Learn how MALDI-TOF, FTIR, and automated DNA/RNA electrophoresis accelerate identification.<h5>2. Phenomenex: Addressing LC Method Optimization - Scaling For Efficiency, Throughput And Reproducibility</h5><ul><li>We, 2.9.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6458">Registration</a></li></ul>Join this webinar on LC method optimization and scaling. Learn how column dimensions, particle morphology, and sample loading strategies maximize throughput and reproducibility.<h5>3. Thermo Fisher Scientific: Proteoform Studio software, top down made simple</h5><ul><li>We, 2.9.2026 14:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6459">Registration</a></li></ul>Learn how Thermo Scientific Proteoform Studio software simplifies top-down MS and intact protein analysis through integrated workflows, interactive deconvolution, and reporting.<h5>4. Agilent Technologies: Targeted Hybridization Capture for Antimicrobial Resistance Surveillance in Complex Environmental Samples</h5><ul><li>We, 2.9.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6455">Registration</a></li></ul>Discover how Agilent SureSelect hybrid capture enhances antimicrobial resistance gene detection and characterization in complex environmental samples compared with shotgun NGS.<h5>5. Thermo Fisher Scientific: Ask the Expert: What to expect from the new Thermo Scientific™ Orbitrap™ Excedion™ Hybrid mass spectrometers</h5><ul><li>Th, 3.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6466">Registration</a></li></ul>Discover the new Orbitrap Excedion Hybrid Mass Spectrometer and learn how enhanced dynamic range, robust performance, and an upgradeable design support advanced HRAM workflows.<h5>6. Waters Corporation: Informatics series #34 Ready for Self-Documenting Chromatography?</h5><ul><li>Th, 3.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6426">Registration</a></li></ul>Speed up root cause analysis with self-documenting LC and Empower software in this 30-minute Waters coffee break.<h5>7. SciY/Mestrelab Research: From Legacy Workflows to Paperless Labs: Track Every Sample, Process, and Decision</h5><ul><li>Th, 3.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6425">Registration</a></li></ul>Transform your lab from paper to digital. Learn how WebLab and LIMS workflows automate sample tracking and support laboratory compliance.<h5>8. SelectScience: ADC characterization in one native LC-MS workflow</h5><ul><li>Fr, 4.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6460">Registration</a></li></ul>Simplify ADC characterization with native RP-LC-MS using Biozen® columns to determine DAR, proteoforms, and positional isomers without buffer exchange.

Webinars LabRulezLCMS Week 36/2026

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The International Symposium on Chromatography (ISC) represents the oldest conference series focussing on separation science. ISC symposia have been organised since 1956 in each even year. ISC is internationally recognised as one of the premier meeting series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.

International Symposium on Chromatography - (ISC)

Separation Science

Technology Networks

GERSTEL

Phenomenex

SelectScience

Waters Corporation

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>Environmental laboratories are increasingly adopting the Biotage® Extrahera™ for automated solid phase extraction (SPE). Compared to traditional workflows, the Biotage® Extrahera™ delivers unprecedented throughput and significant solvent reduction, with reliable precision and accuracy. This presentation will demonstrate how laboratories can achieve measurable workflow improvements for two key environmental SVOC applications.<h4>Extractable Petroleum Hydrocarbon (EPH) fractionation</h4>For EPH fractionation, the dual-flow positive pressure technology of the Biotage® Extrahera™ combined with optimized ISOLUTE® EPH sorbent chemistry delivers consistently high recoveries for both aliphatic and aromatic analytes. This workflow also improves operational efficiency and provides:<ul><li>20x solvent reduction</li><li>3x less SPE sorbent waste</li><li>16x boost in productivity&nbsp;</li></ul>Recent shifts toward smaller sample sizes for the initial EPH extraction introduced new challenges in background contribution from the fraction step. This drove innovations such as automated sample tip cleaning, premium SPE consumables, and best practices to ensure the Biotage® Extrahera™ remained compliant with method blank reporting limits.<h4>Total Petroleum Hydrocarbon (TPH) cleanups</h4>The Biotage® Extrahera™ has also been extended to TPH cleanup workflows, removing polar interferences from soil, surface, ground, and wastewater extracts. &nbsp;Here too, the operational gains are striking:<ul><li>40x solvent reduction&nbsp;</li><li>20x less SPE sorbent waste&nbsp;</li><li>8x boost in productivity&nbsp;</li></ul>Challenges such as the liquid handling of pentane and broad-range hydrocarbon background elimination (C6 – C40) were addressed through careful workflow optimization.<h4>What You’ll Learn</h4><ul><li>Automated SPE optimization for EPH fractionation and TPH cleanup workflows</li><li>Practical solutions to common technical and regulatory challenges</li><li>Compliance strategy for high-throughput and reproducible results with Biotage® Extrahera™</li></ul><h4>Key Benefits:</h4><ul><li>Reliable EPH fractionation into aromatic and aliphatic fractions with reduced sample volume method blanks &lt;5 ppm (MADEP, C9–C18) and &lt;1.8 ppm (RECAP, C16–C35), delivering 70–130% recoveries with high precision and no unwanted fraction breakthrough.</li><li>Robust removal of polar interferences for TPH analysis, achieving method blanks 5 ppm (C6–C44), LCS recoveries &gt;70% (C10–C28, C17–C44), and strong surrogate performance (n-octacosane).</li><li>Practical strategies to improve lab operations through automation, solvent reduction, faster processing, optimized sorbent selection (ISOLUTE® EPH, ISOLUTE® SI), and best practices to minimize background contamination and carryover.</li></ul><blockquote>Presenter: Evan Walters (MSc) (Market Segment &amp; Applications Manager, Biotage®)Evan Walters is a Regional Market Segment &amp; Applications Manager for Biotage and has been with the company for 8 years. &nbsp;He is passionate about science and analytical chemistry in the environmental, food, and agriculture market segments. &nbsp;He has previously held roles as an environmental chemist, geochemist, and technical sales representative. He received a Master of Science in Geochemistry from Southern Illinois University.</blockquote></div></div></div>

SeparationScience: How to Overcome the Technical Hurdles of High-Throughput Sample Preparation for Environmental SVOC Analysis

How to Overcome the Technical Hurdles of High-Throughput Sample Preparation for Environmental SVOC Analysis

How automated SPE with Biotage Extrahera boosts EPH and TPH analysis—cutting solvent use, waste, and processing time while ensuring reliable, compliant results.

Sample Preparation for Environmental SVOC Analysis

As regulatory scrutiny around PFAS (Per- and Polyfluoroalkyl Substances) continues to intensify, laboratories face growing challenges in achieving accurate, low-level detection. Analytical methods have become more sensitive and complex, while regulators demand consistent, defensible data to guide environmental and public health policies. This expert-led roundtable explores the historical evolution of PFAS methods—from early protocols to current EPA 1633 and ASTM standards—and their impact on today’s testing environment.We examine the regulatory trends shaping method adoption, the technical barriers labs must overcome (such as background contamination and instrument sensitivity), and how purpose-designed solutions—PFAS low background consumables—are essential for ensuring data integrity. As PFAS contamination can originate from the very materials used in sample collection and analysis, using certified low-background consumables has become a critical step in achieving reliable results.The discussion also highlights real-world laboratory solutions, including platforms from SCIEX and others, and explores future innovations in sample preparation—for example, solid phase extraction (SPE)—and MS platform enhancements. Whether you're responsible for PFAS method development, compliance, or lab operations, this session will provide the practical and strategic insights needed to stay ahead in a rapidly shifting regulatory and analytical landscape.<h4>Key Learning Points</h4><ul><li>Understand the evolution of PFAS analytical methods.</li><li>Navigate the current regulatory landscape.</li><li>Solve real-world analytical challenges.</li></ul><h4>Who Should Attend</h4><ul><li>Analysts from environmental testing laboratories facing PFAS method validation or implementation.</li><li>Regulatory stakeholders seeking to understand lab capabilities and constraints.</li><li>Chemical analyst and researchers interested in designing sampling and treatment protocols.</li><li>Academics and researchers working on PFAS analysis or environmental toxicology.</li></ul><blockquote>Speaker: Sam Lodge (Environmental Senior Business Development Manager, Phenomenex)Sam Lodge is the Phenomenex Senior Business Development Manager for the Environmental industry. He has been at Phenomenex for over 30 years in various positions, including Key Account Manager and Senior International Sales Manager, and is a product expert in SPE and HPLC chemistries. Over the past 8 years, he has worked extensively with commercial and government labs in the development and support of PFAS analytical methods, including the validation of EPA 533, the MLV for DM 1633, and many internal (MOD) methods. Sam was instrumental in the collaborations that led to the development of several new SPE formats for PFAS, including several different stacked tubes and pass-through GCB cartridges that can help commercial labs to increase productivity and reduce costs. In his spare time, Sam enjoys fishing and surfing (but not at the same time!)Speaker: Dr. Karl Oetjen (Market Development Manager for Environmental, Industrial, Food &amp; Beverage, SCIEX)Karl Oetjen is a Market Development Manager for Environmental, Industrial, Food &amp; Beverage at SCIEX and has over 10 years of mass spectrometry experience. Before joining SCIEX, he completed his PhD at Colorado School of Mines (Golden, Colorado) in Hydrologic Science and Engineering. Karl’s dissertation research focused on nontarget characterization of complex surfactant mixtures, including aqueous film-forming foams. This work led to the discovery of several novel per- and polyfluorinated alkyl substances (PFAS) that have since been found in a variety of environmental samples and industrial chemicals. Since joining SCIEX, Karl has worked with numerous labs creating and implementing both regulated and unregulated quantitative and qualitative screening methods.Speaker: Simon Roberts (Staff Scientist, SCIEX)Simon Roberts is a Staff Scientist at SCIEX and completed a postdoctoral fellowship at the Colorado School of Mines, where he worked with Dr. Christopher Higgins and Dr. Jennifer Field to identify novel classes of PFAS chemicals in aqueous film-forming foams (AFFFs). At SCIEX, Simon specializes in method optimization and data reporting, helping labs across the country set up PFAS and other environmental analytical methods.</blockquote>

Phenomenex: The Future of PFAS Testing: Regulations, Innovation, and Contamination Mitigation

The Future of PFAS Testing: Regulations, Innovation, and Contamination Mitigation

This roundtable discussion highlights regulatory scrutiny and trends around PFAS  as well as real-world laboratory solutions.

PFAS Testing: Regulations, Innovation, Contamination

<div>Smarter Bioanalysis: Driving Consistency and Efficiency in Today’s Labs Discovery and regulated bioanalysis labs strive for simplicity, consistency, robustness and operational efficiency to maximize impact and resource utilization. Optimizing every step of the bioanalytical workflow is key to developing assays that perform consistently over time. As therapeutic modalities continue to evolve, so do the needs of bioanalytical laboratories.In this webinar, Dr. Basile Khara from Alderley Analytical (now a part of Synexa Life Sciences) shares his experiences on how out-of-the-box performance of detergent-free OligoWorks™ SPE Microplate Kit, combined with a robust analytical platform like the Xevo TQ Absolute XR Mass Spectrometer and waters_connect for quantitation software simplifies bioanalytical workflows.<h4>What you’ll walk away with</h4><ul><li>How OligoWorks™ SPE Microplate Kit simplifies oligonucleotide sample preparation</li><li>The implications of having a robust analytical platform that shows consistent performance even after 30,000 injections or protein precipitated plasma</li><li>A simplified, compliant ready informatics platform can streamline data review and help you get to decisions faster</li></ul><h4>Who should attend?</h4>This webinar is designed for you if you are a Research Associate, Scientist, Director, or Lab Manager in pharma, biopharma, biotech, or CROs involved in bioanalysis.Don't miss it.<blockquote>Presenter: Dr. Basile Khara (Principal Scientist, Alderly Analytical (Part of Synexa Life Sciences))Basile Khara is currently the Principal Scientist in the method development team at Alderley Analytical situated in Macclesfield U.K, part of Synexa Life Science Ltd. His leading role focuses on the design and validation of novel LC-MS bioanalysis methods that specifically target chemical entities such as oligonucleotides, proteins and conjugated peptides.Overall, he has accumulated over ten years’ worth of LC-MS quantification and characterization experience in pre-clinical drug discovery and clinical bioanalysis, along with a Ph.D. in chemistry from the University of Manchester.</blockquote></div>

Waters Corporation: Bioanalysis simplified – A case study with Basile Khara

Bioanalysis simplified – A case study with Basile Khara

How OligoWorks™ SPE Microplate Kit simplifies oligonucleotide sample preparation.

Bioanalysis simplified – A case study

<h4>Key Learning Points</h4><ul><li>Understand how SLE and SPE work and how they are different from each other.</li><li>Evaluate the advantages and limitations of each method for various matrices.</li><li>Select the appropriate technique for analyte chemistry and target sensitivity.</li></ul><h4>Who Should Attend</h4><ul><li>LC or LC‑MS users evaluating or optimizing sample prep workflows.</li><li>Analysts working with challenging biological or environmental matrices.</li><li>Scientists who are unsure when to apply SLE vs. SPE for maximum recovery and cleanliness.</li><li>Method developers seeking to improve robustness, throughput, or reproducibility.</li></ul><blockquote>Speaker: Grace Guo &nbsp;(Senior Technical Specialist, Phenomenex)Grace Guo graduated from Johns Hopkins University with a Master’s degree in Material Science and Engineering. She joined Phenomenex Technical Team in 2017 providing technical support globally. With more than 9 years of experience in SPE, HPLC and GC, she delivered 90+ seminars and webinars globally covering food and environmental, clinical, pharma and biopharma industry.</blockquote>

Phenomenex: Extraction Face-Off: Choosing Between SLE and SPE

Extraction Face-Off: Choosing Between SLE and SPE

Understand how SLE and SPE work and how they are different from each other.

Choosing Between SLE and SPE

PFAS contamination in food is an emerging analytical and regulatory challenge, especially as testing expands beyond water into complex food and animal protein matrices. In this webinar, Waters and PromoChrom experts will present practical, largely automated workflows designed to improve robustness, efficiency, and data quality in PFAS food analysis.Using real-world examples such as eggs and other animal proteins, the session will explore sample preparation strategies tailored to matrix complexity and throughput needs. Attendees will see how pressurized solvent extraction, SPE cleanup, and QuEChERS-based approaches can be combined with automation to streamline workflows while maintaining sensitivity and reproducibility.The session will also highlight how labs can prepare for evolving regulations and growing analytical demands in PFAS food testing.<h4>Key Learning Objectives:</h4><ul><li>Understand the current and emerging PFAS testing requirements for food and how to position your lab for compliance</li><li>Compare pressurized solvent extraction, SPE cleanup, and QueChERS approaches to find the right fit for your throughput needs</li><li>Learn which workflow steps benefit most from automation and how to maintain reproducibility at scale</li><li>Discover best practices for ensuring robust, defensible results across different food types</li></ul><blockquote>Speaker:&nbsp;MJ Madden (Technical Support Manager and Project Manager, PromoChrom Technologies) Speaker:&nbsp;Margot Lee (Senior Scientist, Waters Corporation)</blockquote>

Technology Networks: Episode 3: PFAS in Food – Addressing Contamination in the Food Supply Chain

Episode 3: PFAS in Food – Addressing Contamination in the Food Supply Chain

Understand the current and emerging PFAS testing requirements for food and how to position your lab for compliance

Addressing Contamination in the Food Supply Chain

<h3>Bringing laboratory automation to life with Andrew+ and OneLab</h3>This webinar series explores how Andrew+ automated liquid handling and OneLab workflow software support consistent, traceable and efficient laboratory operations. Through application‑focused episodes, you will see how automation can be successfully integrated into everyday laboratory workflows, from method development to routine and regulated environments, supported by real‑world customer experiences and testimonials.<h4>Episode 4 – Food &amp; Environmental Workflows</h4><h4>Overview</h4>Food and environmental testing laboratories face complex matrices, high sample volumes and strict quality requirements. This episode highlights how automation helps standardise sample preparation while reducing manual workload and operational risk, with direct insight from laboratories applying these solutions in routine testing.<h4>Key highlights</h4><ul><li>Standardise sample preparation in complex food and environmental matrices</li><li>Improve repeatability by automating pipetting and solid phase extraction (SPE) workflows</li><li>Support auditing, troubleshooting and regulatory needs through automated workflow documentation</li></ul><blockquote>Speaker: Xavier Rodriguez (Principal Applications Specialist, Chemistry, Europe - Waters Corporation)Xavier is part of the European Market Development Team. He works as an Application Specialist with focus on sample prep and has more than 20 years of experience in solving sample prep challenges.Customer testimonials: Labexia – Groupe CARSOLabexia is part of Groupe CARSO, a European analytical services group specialising in food testing, environmental analysis and routine laboratory services.In this episode, Labexia shares how automation has been implemented in day‑to‑day food testing workflows to streamline pipetting and sample preparation activities. The testimonial illustrates how automated liquid handling helps free up technicians’ time, improve repeatability and reduce the risk of musculoskeletal strain in routine laboratory operations.</blockquote><h5>Reserve Your Spot Today!</h5>

Transform Your Daily Lab Operations with Automation - Food and Enviromental Workflows

Automate food and environmental testing workflows. Learn how Andrew+ and OneLab standardize sample prep, automate SPE, and improve laboratory traceability

Automated Food & Environmental Lab Workflows

By attending this webinar you will:<ul><li>Gain practical approaches for detecting unknown PFAS in consumer goods and environmental samples</li><li>Understand a simplified LC-MS/MS workflow for sensitive, compliant PFAS analysis in animal-derived foods</li><li>Understand PFAS contamination risks in food and evolving regulatory expectations</li><li>Explore automated and semi-automated PFAS workflows for complex food matrices.</li></ul><h5>Presentation 1: Hydrolysis as a Critically Important Step in the Analysis of Fluorotelomer Alcohols in Textiles and Other Products</h5><ul><li>Vladimir Nikiforov, Senior Scientist, Environmental Chemistry and Health Effects, NILU, Tromsø</li></ul>In this webinar, a simple hydrolysis-based approach for identifying and accounting for PFAS precursors in consumer products and environmental samples will be presented by its creator. The theory behind the method will be explained. Advantages and limitations of the recently certified EN 17681-1:2025 method will be discussed. Hydrolysis will be compared to oxidation as an alternative/complementary work-up for release of perfluoroalkyl substances.The presentation will focus on fluorotelomer alcohol (FTOH)-based precursor compounds, including polymeric materials that may degrade into regulated or hazardous PFAS. Attendees will learn how a straightforward hydrolysis procedure can convert precursor compounds into detectable free FTOHs while preserving valuable structural information for source identification and risk assessment. Case studies from textile extracts will demonstrate how preliminary hydrolysis revealed up to 1300-fold higher levels of previously “hidden” FTOHs compared to conventional analysis alone.<h5>Presentation 2: PFAS Analysis in Animal‑Derived Foods Using a Direct Blend &amp; Inject LC‑MS/MS Workflow</h5><ul><li>Phil Taylor, Marketing Lead – Food &amp; Environmental, PerkinElmer</li></ul>Per‑ and polyfluoroalkyl substances (PFAS) present major analytical challenges in animal‑derived foods due to complex matrices and tightening regulations. This presentation demonstrates a direct Blend &amp; Inject LC‑MS/MS workflow for quantifying 25 PFAS compounds aligned with EPA Method 533 and EU requirements. The approach delivers ppt‑level sensitivity, excellent linearity, and robust performance without solid‑phase extraction.<h5>Presentation 3: PFAS in Food – Addressing Contamination in the Food Supply Chain</h5><ul><li>Margot Lee, Senior Scientist, Waters Corporation &nbsp;and &nbsp;MJ Madden, Technical Support Manager and Project Manager, PromoChrom Technologies</li></ul>PFAS contamination in food presents a growing analytical and regulatory challenge, particularly as attention expands beyond water into complex food and animal protein matrices. In this session, Waters and PromoChrom experts explore practical, mostly automated workflows designed to improve robustness, efficiency, and data quality in PFAS food testing.The presentation will feature real-world examples of PFAS analysis in food matrices, including eggs and animal proteins, highlighting different sample preparation strategies adapted to matrix complexity and laboratory throughput needs. Attendees will gain insight into how pressurized solvent extraction, SPE cleanup, and QuEChERS-based approaches can be combined with automation to streamline workflows while maintaining sensitivity and reproducibility.As PFAS testing in food continues to evolve, this session will also provide a forward-looking view on emerging workflow optimizations and how labs can prepare for expanding regulations and increasing analytical demands.<h5>What you need to know:</h5><ul><li>Duration: Approximately 90 minutes</li></ul><blockquote>Presenter: Vladimir Nikiforov (Senior Scientist, Environmental Chemistry and Health Effects, NILU, Tromsø)Vladimir Nikiforov is a senior scientist at NILU, working on method development for new types of analytes, with 40+ years experience in “PFAS” chemistry. He is a synthetic organic, organofluorine and physical organic chemist by background. In addition, he has 30+ years of experience in environmental chemistry with emphasis on trace organic analytical chemistry. Key expertise and research interest are: QSAR, PFAS, NTS, SVOC, suspect screening, microplastic, synthesis of standards, method development, GC, LC, MS, NMR, fate models, transformation products, reactivity of organic molecules, transformation kinetics, persistency, UV-compounds, tire additives, air sampling, air monitoring, Arctic pollution, derivatization methods, structure elucidation, international regulation, and chemical education. Previous publications and projects can be found here.</blockquote><blockquote>Presenter:&nbsp;Phil Taylor (Marketing Lead – Food &amp; Environmental, PerkinElmer)Phil Taylor is a Marketing Leader for Food &amp; Environmental markets at PerkinElmer, bringing nearly 20 years of experience across analytical chemistry, LC‑MS/MS applications, and science‑driven marketing. With a background spanning water analysis, food and environmental testing, and global LC‑MS/MS workflow launches, he specializes in translating complex analytical challenges into practical, regulation‑ready solutions for routine laboratories.</blockquote><blockquote>Presenter:&nbsp;Margot Lee (Senior Scientist, Waters Corporation)Margot Lee is a Senior Scientist at Waters Corporation, where she develops applications for PFAS (per- and polyfluoroalkyl substances) analysis using LC-MS/MS. She has worked at Waters since 2022 and has a background in biology with a career in analytical chemistry. After contributing to the validation of Waters’ dual-phase SPE cartridges for PFAS analysis, she joined the PFAS applications team in 2024. Her current work focuses on manual and automated extractions of PFAS in environmental and food matrices. She is passionate about advancing understanding of contaminants that impact public health and sharing practical methods that support the critical research of scientists around the world.</blockquote><blockquote>Presenter: MJ Madden (Technical Support Manager and Project Manager, PromoChrom Technologies)MJ Madden (They/She) earned a Master’s in Chemistry with honors from the University of British Columbia and joined PromoChrom Technology in 2023. As Technical Support Manager and Project Manager for new product development, MJ combines scientific expertise with a passion for customer success. They are currently leading initiatives to expand PromoChrom’s support services, including the launch of a comprehensive online support guide and enhanced field service capabilities for repairs and preventive maintenance. MJ brings a forward-looking perspective to environmental technology, helping customers adopt innovative solutions with confidence. &nbsp;</blockquote>

Separation Science: Advancing PFAS Analysis - From Hidden Precursors to Food Safety Workflows

Advancing PFAS Analysis: From Hidden Precursors to Food Safety Workflows

Master PFAS contamination analysis. Discover hydrolysis for textils/precursors and automated direct Blend & Inject LC-MS/MS workflows for food matrices

Advancing PFAS Analysis: Hidden Precursors & Food Safety

The presence of antibiotics in aquatic environments is a growing analytical challenge, with trace-level contamination posing significant risks to ecosystems and contributing to antimicrobial resistance. Accurate, reliable and high-throughput sample preparation is therefore essential for effective water quality monitoring.This webinar will demonstrate the use of the Biotage® PrepXpert-8 automated solid-phase extraction (SPE) system for the simultaneous extraction and enrichment of multiple antibiotic classes, including fluoroquinolones, tetracyclines, sulfonamides and macrolides from water matrices.We will cover method development considerations, sorbent selection and the advantages of full automation in reducing operator variability and improving reproducibility. Quantitative data and method performance metrics will be presented and discussed.Whether you are new to SPE or looking to streamline existing workflows, this webinar offers practical insights for modern environmental water analysis.By attending this presentation, you will:<ul><li>Gain practical knowledge of automated SPE method development for extracting multiple antibiotic classes from water matrices using the Biotage® PrepXpert-8.</li><li>Learn key sorbent selection strategies and see real quantitative recovery data to support your own method implementation.</li><li>Leave equipped to streamline your sample preparation workflows and improve reproducibility in water analysis.</li></ul><h5>Who should attend?</h5>This webinar is ideal for analytical and environmental chemists, water quality scientists and laboratory managers working in environmental monitoring, regulatory compliance, or pharmaceutical research who are involved in trace-level contaminant analysis.<h5>What you need to know:</h5>Start times:<ul><li>Broadcast 1: 8 am BST (London/Lisbon) / 9 am CEST (Paris/Berlin) / 12:30 pm IST (New Delhi) / 3 pm CST (Beijing) / 4 pm JST (Tokyo)</li><li>Broadcast 2: 8 am CDT (Chicago) / 9 am EDT (New York) / 2 pm BST (London/Lisbon) / 3 pm CEST (Paris/Berlin)</li><li>Broadcast 3: 10 am PDT (Los Angeles) / 12 pm CDT (Chicago) / 1 pm EDT (New York)</li></ul>Duration: 1 hour<blockquote>Presenter: Vainius Skukauskas (Applications Chemist, Biotage EMEA Application Laboratory, Cardiff, UK)Dr. Vainius Skukauskas is an Applications Chemist at the Biotage EMEA Application Laboratory in Cardiff, UK. With a Ph.D. in chemistry and extensive expertise in analytical method development, he specializes in developing and optimizing automated sample preparation workflows across a wide range of industries, with a particular focus on the environmental and food sectors. He works closely with customers to translate complex methods into robust, high-throughput solutions, and regularly delivers technical demonstrations, training, and workshops across EMEA.</blockquote>

Separation Science: Advances in Antibiotic Extraction from Water - An Automated SPE Approach

Advances in Antibiotic Extraction from Water: An Automated SPE Approach

Advance water quality monitoring. Discover automated SPE method development and sorbent selection for trace-level antibiotic extraction with Biotage

Automated SPE Approach for Antibiotic Extraction from Water

From high-throughput extraction and anti-clogging strategies to up-concentration and LC-MS/MS analysis.PFAS analysis in aqueous matrices requires robust sample preparation, reliable clean-up, and consistent recoveries - especially as ultra-short-chain PFAS such as TFA are gaining increasing regulatory attention.In this Velaris webinar, experts from PromoChrom and LCTech will present automated SPE-based workflows for PFAS analysis in drinking water, environmental water, wastewater, and other aqueous matrices compliance with methods such as EPA 533, EPA 537.1, EPA 1633, and EU Method 17892.The session will cover fully automated SPE with the PromoChrom SPE-03 platform, anti-clogging solutions for challenging samples, optimized PFAS SPE cartridges, and Velaris solutions for the extraction of ultra-short-chain PFAS.The webinar will also introduce the D-EVA vacuum concentrator for unattended sample concentration and show how automated sample preparation can support high throughput, reproducibility, low background levels.<blockquote>Presenter: Keith Keegan (Lead Applications Engineer, PromoChrom)Keith Keegan will focus on the PromoChrom SPE-03 platform for fully automated SPE, workflow efficiency, anti-clogging strategies, real-world laboratory use, and future-oriented tools such as real-time monitoring and remote fleet management.</blockquote><blockquote>Presenter: Dr. Suman Kharel (Application Specialist, LCTech)Suman Kharel will present optimized SPE cartridges for PFAS analysis, Velaris solutions for ultra-short-chain PFAS, performance data for aqueous matrices, and the use of D-EVA for unattended concentration before LC-MS/MS analysis.</blockquote>

GERSTEL: Automated SPE Sample Preparation for PFAS and Ultra-Short-Chain PFAS in Aqueous Matrices

Automated SPE Sample Preparation for PFAS and Ultra-Short-Chain PFAS in Aqueous Matrices

Master automated PFAS sample prep. Learn SPE-03 extraction techniques and D-EVA concentration for ultra-short-chain PFAS in compliance with EPA 1633

Automated SPE for Ultra-Short-Chain PFAS in Water

In this SelectScience® TechTalk, Dr. Stefan Christian Gaugler, Professor of Applied Analytics at the Institute for Chemistry and Bioanalytics, University of Applied Sciences Northwestern Switzerland (FHNW), will provide an up-to-date overview of per- and polyfluoroalkyl substances (PFAS), focusing on their environmental impact, regulatory landscape, and associated analytical challenges. Highlighting the growing concern surrounding PFAS contamination across Europe, alongside the complexity arising from their chemical diversity and persistence.The session will explore current analytical workflows and sample preparation techniques, including the use of a novel PFAS-selective polymer for micro solid-phase extraction (µSPE), supporting efficient and automated analysis across diverse sample matrices. Attendees will gain insight into approaches for detecting both ultra-short and long-chain PFAS, as well as practical strategies to improve sensitivity, selectivity, and sustainability in PFAS analysis.<h4>What will this webinar cover?</h4><ul><li>The environmental relevance and regulatory developments surrounding PFAS in Europe.</li><li>The analytical challenges associated with PFAS diversity, including ultra-short and long-chain compounds.</li><li>Modern analytical workflows for PFAS detection using LC-MS/MS and GC-MS/MS techniques.</li><li>The advantages of novel PFAS-selective polymer-based µSPE methods for efficient and automated sample preparation.</li></ul><blockquote>Speaker: Prof. Dr. Stefan Christian Gaugler (Professor of Applied Analytics at the Institute for Chemistry and Bioanalytics, University of Applied Sciences Northwestern Switzerland (FHNW))Prof. Dr. Stefan Christian Gaugler is a researcher and lecturer at FHNW with a background in life sciences and analytical chemistry, driven by a long-standing interest in translating complex biomarker diagnostics into accessible solutions. Over the past 14 years, his work has focused on microsampling technologies, particularly dried blood spot (DBS) analysis.He currently leads the micro lab at FHNW, where the team operates one of the world’s most technologically advanced dried blood spot laboratories and develops advanced methods for trace analysis of emerging contaminants. Alongside his research, he teaches advanced analytical techniques and laboratory automation, with a strong focus on bridging academia and real-world application.His current work, including this presentation, focuses on advancing PFAS analysis to better understand and address their impact on human health and the environment.</blockquote><blockquote>Moderator: Cameron Smith-Craig (Pharma and Applied Sciences Editor, SelectScience)</blockquote>

SelectScience: Advancing PFAS analytics across complex matrices

Advancing PFAS analytics across complex matrices

Discover automated µSPE solutions for PFAS analysis. Learn strategies from FHNW experts to overcome matrix challenges for ultra-short & long chains.

LCMS webinars focusing on SPE - page 1