Czech researchers from Charles University, Prague, led by Pavla Eliášová, have developed an advanced photocathode that helps convert the greenhouse gas carbon dioxide into pure ethanol using sunlight. The new technology solves a long-standing problem of material degradation in water, achieves record conversion efficiency, and opens the way toward sustainable production of green fuels.Converting carbon dioxide (CO2) into useful fuels using solar energy represents the holy grail of modern green chemistry. The device enabling this conversion is called a solar reactor. Its key element is a photocathode: a material that absorbs light and enables the chemical reaction. Cuprous oxide long appeared to be an ideal material because it is inexpensive, readily available, and excels at capturing solar rays. In practice, however, it faced a fundamental obstacle: in an aqueous environment under light, it transforms and degrades extremely rapidly—much like iron undergoing swift corrosion—and loses its functionality within just tens of minutes.The team from the Chemistry Section of the Faculty of Science, CU, led by Pavla Eliášová, in collaboration with Tomáš Hrbek from the Faculty of Mathematics and Physics, CU, resolved this issue by creating a unique "nano-sandwich". The scientists combined cuprous oxide with advanced two-dimensional materials called MXenes and, through precisely controlled heating, created an ultrathin layer of titanium dioxide on their surface. MXene modified in this way can rapidly drain electric charge from the cuprous oxide, thereby slowing down its decomposition. At the same time, it uses the charge further to convert carbon dioxide into liquid fuel."Surface-engineered MXene combined with cuprous oxide allowed us to unite the best of both materials. The copper base enables maximum utilization of light energy, while the conductive MXene framework ensures that the material remains active even after many hours of operation," explains research team leader Pavla Eliášová from the Chemistry Section of the Faculty of Science, Charles University.In laboratory tests, the new photocathode achieved a record solar-energy-to-ethanol conversion efficiency of 2,74 %. A crucial improvement is the formation of only a single product. While other systems often produce a mixture of byproducts, the material designed by the research team produces pure ethanol as its sole liquid product, which significantly simplifies its potential industrial application."This is a major step forward for us. On our laboratory scale, the system works very well and produces ethanol over many hours. In the next step, we want to further reinforce the stability of the entire photocathode and begin testing on a larger scale and under real daylight conditions," adds physical chemist Pavla Eliášová.The research was conducted within the international European project DESIRED (Horizon Europe), with support from the Charles University Research Centre (UNCE) and the L'Oréal-UNESCO For Women in Science program.<blockquote><h4>Article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/aenm.71469">Surface-Engineered Ti3C2Tx MXene/Cu2O Photocathodes for Highly Selective Photoelectrocatalytic CO2 Reduction to Ethanol</a></h4>Luis A. M. Carrascosa, Magdaléna Linková, Monika Remzová, Tomáš Hrbek, Pavla EliášováAdv. Energy Mater., 2026, 16, e71469<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/aenm.71469">https://doi.org/10.1002/aenm.71469</a><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>Cu2O is an inexpensive p-type semiconductor that promotes the photoelectrocatalytic CO2 reduction reaction (PEC CO2RR). While its low bandgap enables photoexcitation by visible light, long-term stability remains limited due to quick charge recombination and photocorrosion. Here, we enhanced charge separation and extraction by combining Cu2O with surface-engineered MXenes. In this novel architecture, TiO2 grows in situ on the surface of Ti3C2Tx and serves as a charge-transport layer, forming a junction with Cu2O. On the other side, the outer TiO2 surface exposed to the CO2-saturated electrolyte offers catalytically active sites for CO2 reduction. Acting as a central layer, the MXene conductive backbone provides an electronically continuous pathway for electron transport. In PEC CO2RR, the photocathode containing 50 wt.% of MXene and a balanced amount of TiO2 on the Ti3C2 surface outperformed the best Cu/CuxO-based systems operating in non-organic electrolytes reported in the literature. The FTO/Cu2O/ml-Ti3C2Tx-350-N2 photocathode reached 8.4&nbsp;µmol&nbsp;cm−2 h−1 ethanol production rate and 2.74% solar-to-ethanol efficiency after 2&nbsp;h. Moreover, pairing TiO2-MXene with Cu2O significantly stabilized the photocathode, which maintained 76% of the ethanol production rate after 6 h. Overall, our results establish surface-engineered Cu2O/TiO2-MXene heterostructures as a solid platform for highly selective, visible-light-driven ethanol production with significantly improved operational stability.

Researchers from Charles University, Prague, Have Developed a New Photocathode for Efficient Conversion of CO2 into Ethanol

News from LabRulezLCMS Library - Week 42, 2026

Autumn has already turned the leaves into vibrant shades, and with the end of the year approaching, we would like to thank you - before the first snowflakes arrive - for your trust, cooperation, and continued interest in our products and services.As a long-standing distributor of Thermo Scientific Finnpipette products, we know that the accuracy and reliability of laboratory results often begin with seemingly small details. Choosing the right pipette and tip is one of the first steps toward a successful analysis.That is why we have prepared an EXCLUSIVE offer to help you replenish your laboratory supplies at a more attractive price, while also thanking you for your continued cooperation and trust.<blockquote>EXCLUSIVE OFFER valid until the end of 2026<ul><li>10% off tips</li><li>10% off pipettes</li></ul>Enter the code “KAŠTANY” in your order or include it in your order e-mail.*For larger orders, an additional discount may be available.</blockquote><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/analytika_pipety_a_spicky_thermo_20c5943161.jpg" alt="analytika: Thermo Scientific Pipettes and Tips" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_analytika_pipety_a_spicky_thermo_20c5943161.jpg 146w," sizes="100vw" width="1500" height="1605"><h4>LIMITED OFFER WHILE STOCKS LAST</h4><h5>Everything ages. 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The main mission of the Faculty of Science is to create highly qualified experts in biology, chemistry, geography, geology and in other interdisciplinary fields. Its scientific and research effort aims to solve key problems concerned with the development of human society. Some of the priority long-term subjects are human health, the study of the function and prediction of the development of ecosystems and the biosphere, and the development of environmentally-friendly materials based on the utilization of renewable resources.

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<h4>LC Coffee Breaks Free Webinar Series</h4>Each episode focuses on answering a specific challenge faced by chromatographers, helping you improve efficiency, solve problems faster, and stay up to date with the latest trends in Liquid Chromatography.<h4>Episode 4</h4><h4>Why My Method Doesn't Transfer Smoothly?</h4><h5>What will you learn</h5>Method transfer issues can lead to delays, inconsistent data, and costly rework. Join this webinar to:<ul><li>Understand the root causes of transfer failures</li><li>Learn best practices for achieving reliable, reproducible liquid chromatography methods across different systems and environments</li></ul><h5>Why you should attend</h5><ul><li>Get practical, users insights you can immediately apply in your daily LC laboratory work.&nbsp;</li><li>In just a short coffee-break session, you'll gain valuable tips on troubleshooting, method development, method transfer, technology updates, column chemistries, and real-world applications.</li></ul><blockquote>Speaker: Norris Wong (Senior Evaluation Scientist, Waters Corporation)Norris Wong is a Senior Evaluation Scientist at Waters Corporation from the Validation and Competitive Analysis Group in the LC-MS business unit. He graduated from Bowdoin College with a degree in Biochemistry. Prior to Waters, he worked in the pharmaceutical industry at a CRO, performing cGMP and R&amp;D extractable/leachable analysis using LC and GC instruments. His current work at Waters focuses on evaluating LC system performance and method transfer across LC systems with compendial methods.</blockquote>

LC Coffee Breaks: Why my Method Doesn't Transfer Smoothly?

Learn why LC method transfer fails and how to fix it. Discover best practices for seamless method transfer across instruments in this Waters webinar

Why LC Method Transfer Fails & How to Fix It

Join this webinar to learn how Agilent MassHunter Explorer supports efficient non-targeted LC/MS data analysis, from feature finding and statistical evaluation to compound identification. Practical examples will show how Explorer helps compare sample groups, prioritize relevant compounds, and gain structural insights using tools such as SIRIUS/CSI:FingerID.<blockquote>Presenter: Hannah Florance (Application Specialist LC/MS, Agilent Technologies)Hannah has had multiple roles in the life sciences, starting as a protein chemist, before moving into proteomics and then metabolomics. A major part of her time working in academia involved running LC and GC/MS core facilities supporting projects ranging from synthetic biology to cancer research. She is currently an LC/MS applications specialist for Agilent.Presenter: Stefan Schaebler (Application Specialist LC/MS, Agilent Technologies)Stefan completed his PhD in Biology, specialising in LC/MS based lipidomics and metabolomics. Following his doctoral studies, he joined Agilent Technologies as an LC/MS Application Specialist. In this role, Stefan focuses on small molecule applications using LC/QTOF, with a strong emphasis on software tools and data interpretation.</blockquote>

Agilent Technologies: MassHunter Class 2.0: Smarter Workflows from Acquisition to Insight

MassHunter Explorer: From Data Processing to Structural Insights

Join this webinar to learn how Agilent MassHunter Explorer supports efficient non-targeted LC/MS data analysis

MassHunter Explorer

In this webinar, we will show how MassHunter BioConfirm supports biomolecule characterization workflows, including intact protein analysis (with DAR as option), protein digests, released glycans, and oligonucleotide analysis with TPI and SC. Through workflow-based examples, the session will highlight efficient data review and reliable result confirmation.<blockquote>Presenter: Dr Christian Klein (Biopharma Application Specialist, Agilent Technologies)With an education in Chemistry, Chris Klein received his PhD in 2005 at the Max-Planck-Institute for Biochemistry in Martinsried, Germany. After a PostDoc and 3 years as demo chemist and product specialist with Bruker Daltonics in California, Chris joined Agilent Technologies’s LC/QTOF R&amp;D team in 2010 and took in 2018 the role as LC/QTOF and IM/QTOF Product Manager. In 2025 he returned to Germany as Biopharma Application Specialist in Waldbronn.Presenter: Larissa Hoell (Application Specialist LC/MS, Agilent Technologies)With an education in Biology, Larissa received her M.Sc. from Julius-Maximilians-University Würzburg in 2017, specialising in mass spectrometry and proteomics. After working with high-resolution mass spectrometry at the University of Regina in Canada and at Intertek, she joined Eurofins as Study Director for Residue Analysis. In 2025, Larissa joined Agilent Technologies in Waldbronn as a Pre-Sales LC/MS Application Specialist, supporting Biopharma and Life Science applications using LC/QQQ and LC/QTOF systems.</blockquote>

MassHunter BioConfirm Workflows for Biomolecule Characterization

In this webinar, we will show how MassHunter BioConfirm supports biomolecule characterization workflows,

MassHunter BioConfirm Workflows for Biomolecules 

<h3>Spend more time driving results</h3>The new powerful capabilities of SCIEX OS software version 5.0 is designed to help laboratories overcome everyday workflow challenges, from time-consuming report creation and complex data analysis to increasing demands for productivity and faster decision-making. Join this webinar to discover how the latest enhancements can help streamline your processes, reduce manual effort, and give you greater confidence in your results.<h4>Get an inside look on how to:</h4><ul><li>Create and modify reports faster and easier with Report Studio, a new report template editor</li><li>Interpret results more efficiently with improved performance of calculated columns in analytics</li><li>Improve productivity with the AI assistant</li></ul>Explore how the new features of SCIEX OS 5.0 software can help you stay focused on what matters most.<blockquote>Speaker: to be announced</blockquote>

SCIEX OS 5.0 software demo day

Discover SCIEX OS 5.0 core features. Learn how Report Studio, improved calculated columns, and an AI assistant streamline everyday LC-MS workflows

SCIEX OS 5.0 Software Demo Day Features

<h4>Enabling Walk-Up Mass Confirmation for Synthetic Oligonucleotides: Simplifying LC-MS Analysis with ReadyAccess and BioAccord</h4>Oligonucleotide and RNA therapeutics are advancing rapidly, creating new possibilities for addressing complex diseases while increasing the need for robust, accessible analytical workflows. From synthetic oligonucleotides and antisense oligonucleotides to siRNA, mRNA, and CRISPR single-guide RNA, these molecules must be carefully characterized to confirm molecular mass, sequence identity, purity, and critical modifications. Reliable analytical methods are also essential for understanding impurities, improving method robustness, and supporting confident decisions throughout research, development, and quality control.In this third annual, three-week webinar series, scientists from Waters Corporation and collaborators from Synthon and BioSpring will explore current challenges and practical approaches for oligonucleotide analysis. Topics will include improving the robustness of ion-pair reversed-phase LC-UV-MS methods, expanding access to walk-up mass confirmation for synthetic oligonucleotides, and applying LC-MS oligo mapping and tunable RNase digestion to advanced RNA characterization.Join us as we explore the science of oligos and the power of LC, LC-MS, informatics, and complementary analytical workflows to characterize them with greater confidence.Confirming the molecular mass of synthetic oligonucleotides is essential during discovery and development, yet access to LC-MS analysis can be limited by reliance on specialist operators and centralized laboratories.In this webinar, we explore a walk-up approach using ReadyAccess software with the BioAccord LC-MS System, supported by deconvolution and data management in Empower. Learn how accessible acquisition and automated processing can help oligonucleotide scientists independently confirm molecular mass, assess sample quality, reduce turnaround times, and streamline routine decision-making across research and development laboratories.<h4>Why you should attend</h4><ul><li>Understand how walk-up LC-MS can expand access to intact-mass confirmation for synthetic oligonucleotides.</li><li>See how ReadyAccess and BioAccord can simplify sample submission, acquisition, and results review.</li><li>Learn where Empower deconvolution can support oligonucleotide mass confirmation and compliant workflows.</li><li>Identify opportunities to reduce turnaround time and reliance on centralized MS experts.</li></ul><h4>Who should attend</h4>This webinar is designed for synthetic oligonucleotide chemists, analytical scientists, medicinal chemists, LC-MS laboratory managers, informatics leads, and R&amp;D teams seeking accessible intact-mass confirmation workflows.<blockquote>Presenter: Heidi Gastall (Principal Product Manager, Process Analytics, Waters Corporation)Heidi Gastall is a Principal Product Manager at Waters Corporation. She received her Ph.D. from the University of Oxford and holds an MSci and BA (Hons) from the University of Cambridge.Since joining Waters in 2019, she has held roles in applications chemistry, product ownership, and product management. Her work focuses on developing accessible software and LC-MS solutions for biopharmaceutical scientists, including ReadyAccess, BioAccord, waters_connect, and Empower workflows for synthetic oligonucleotide mass confirmation and analysis.</blockquote>

Waters Corporation: Walk-Up Mass Confirmation for Synthetic Oligonucleotides

Walk-Up Mass Confirmation for Synthetic Oligonucleotides

Learn how Waters BioAccord LC-MS with ReadyAccess and Empower enables walk-up mass confirmation for synthetic oligonucleotides to speed up R&D

Walk Up Mass Confirmation of Oligonucleotides

<h4>Get Tips on Current Dissolution Challenges Meet with industry experts: Join the Dissolution Discussion Group webinars.</h4>The process of preparing and analyzing dissolution samples is intricately linked, forming a vital part of the overall workflow. To address this connection, we are bringing together our team of dissolution and HPLC product specialists for the upcoming Dissolution Discussion Group meeting. During the session, our experts will explore the dissolution workflow in depth, highlighting strategies to optimize sample preparation and ensure a seamless transition to LC analysis. By focusing on practical insights and best practices, the meeting aims to help participants achieve consistently reliable results, from initial preparation through to the final analytical finish.Dissolution testing involves a series of unit operations, each of which can be automated. But which step is the right one to automate your lab?Join us for this webinar as we explore the latest regulations on automation and provide expert guidance on implementing new automation steps tailored to your laboratory's needs. Whether you're a seasoned professional or just starting out, this session is designed to help you navigate the path to increased automation, ensuring your lab operates at its best.<blockquote>Presenter: Karen Krauel-Göllner, PhD (Product Manager Dissolution, Agilent Technologies, Inc.)Karen Krauel-Göllner is a registered pharmacist and holds a PhD in Pharmacy from the University of Otago, New Zealand. Karen has worked in various roles in the field of pharmaceutical development. For the last 10 years she has been working at Agilent Technologies and currently holds a position as product manager for dissolution systems.Presenter: Ken Boda (Dissolution Product Specialist, Agilent Technologies, Inc.)Ken joined Varian (now Agilent) in 2005 as an applications engineer and is now a dissolution product specialist. Prior to working at Agilent, he worked in pharma specializing in dissolution testing and method development. As a dissolution product specialist, Ken works with customers in determining the best systems for their needs and optimizing their workflows. He has also helped educate customers on dissolution science through webinars, the Dissolution Discussion Group, LinkedIn, and other channels.Presenter: Bryan Crist (President, DissoAssist Consulting, Wilmington, NC, USA)Bryan has been the president of DissoAssist Consulting based in Wilmington, NC, USA since 2021. He provides consulting, coaching, and training services for dissolution and drug release in the pharmaceutical industry. Bryan is also an active member on various USP Expert Committees. Previously, Bryan was a scientific affairs manager with Agilent Technologies located in Cary, North Carolina, USA. From 1997 to 2021, he focused on providing method and technical application support for dissolution and drug release testing in the pharmaceutical industry as well as working with VanKel, Varian, and eventually Agilent. Prior to 1997, Bryan supervised and managed pharmaceutical laboratories and performed analytical testing with Bristol-Myers Squibb, Merck, AAI, and Abbott Laboratories until he joined the dissolution equipment manufacturer VanKel.Presenter: Vivian Gray (Founder VA Gray Consulting; Managing Director of Dissolution Technologies)Vivian has spent the last 40+ years involved in all aspects of dissolution testing and evaluating new dissolution technology. At the United States Pharmacopeia, she enjoyed a long career serving first as a bench chemist, supervisor, and lastly as a liaison to various expert USP committees. In 1997, Vivian joined the DuPont-Merck Pharmaceuticals Company Analytical Research and Development Section as the head of the Dissolution Group. In 2002, she formed her own consulting business, V. A. Gray Consulting, Inc., in dissolution testing and related areas. In June 2003, she became managing director of Dissolution Technologies, a peer-reviewed journal dealing specifically with dissolution testing issues.Presenter:&nbsp;Vikas Chander (Product Specialists, Agilent Technologies, Inc.)Vikas Chander is one of our new Product Specialists! Vikas officially joined Agilent on May 5th 2025, bringing with him a strong background in HPLC and technical support. Vikas studied Pharmaceutical Analysis at the University of Strathclyde in Glasgow, UK, and began his career with Phenomenex-India as a Senior Technical Consultant, where he focused on LC column applications development, troubleshooting, and technical support. Most recently, Vikas worked at Thermo Fisher Scientific as a Field Applications Scientist, providing both pre-sales and post-sales support across Canada and parts of the U.S. His primary areas of expertise included Cannabis method development, small molecule pharmaceutical applications and general HPLC support. Outside of work, Vikas, who is based in Cambridge, Canada, likes to travel and enjoy time with family, watching and playing cricket, and listening to Bollywood music.</blockquote>

Agilent Technologies: Let's Talk - from Dissolution Sample Preparation to LC Finish

Let's Talk - from Dissolution Sample Preparation to LC Finish

Learn how to optimize dissolution testing from sample prep to LC finish. Implement step-by-step automation aligned with regulatory standards

Dissolution Sample Prep to LC Automation

<h4>Discover How CDMS Accelerates AAV Development and Reveals Deeper Viral Vector Insights</h4>Better insights. Better decisions. Better gene therapies. Join experts from Lexeo Therapeutics and Waters to discover how Xevo™ CDMS is empowering gene therapy teams to optimize AAV manufacturing processes, uncover hidden vector heterogeneity, and gain deeper insights into emerging viral vectors, including Lentivirus, Adenovirus, and VLPs. Learn how advanced vector characterization enables more confident development decisions, accelerates process optimization, and helps bring higher-quality gene therapies to patients faster.<h5>Why you should attend</h5><ul><li>Gain deeper insight into AAV vector quality by resolving empty, partial, full, and higher-order capsid populations, enabling more informed development and process decisions.</li><li>See how CDMS drives AAV process optimization through real-world application across manufacturing, purification, and scale-up, while complementing orthogonal techniques such as AUC and Mass Photometry.</li><li>Discover how CDMS expands to characterize emerging viral vectors such as adenovirus, lentivirus, and VLPs, driving improved quality assessment and faster development of next-generation genetic medicines.</li></ul><h5>This webinar is designed for:</h5><ul><li>Analytical scientists, process development teams, and CMC professionals seeking deeper insights into AAV vector quality, genome packaging, and process optimization.</li><li>Gene therapy researchers and viral vector developers working with AAVs, adenoviruses, lentiviral vectors, VLPs, and other emerging genetic medicine modalities.</li><li>Scientific leaders, technical decision-makers, and program stakeholders in pharmaceutical and biotechnology companies, CDMOs, CROs, and academic institutions who are evaluating advanced characterization strategies to accelerate development timelines and enhance product quality.</li></ul><blockquote>Speaker: Noah Miller-Medzon (Scientist, Lexeo Therapeutics)Noah Miller-Medzon is a Scientist II at Lexeo Therapeutics and serves as the technical lead for downstream process development across the company's AAV gene therapy portfolio.He has led the development of downstream purification processes across Lexeo's programs and focuses on process optimization, manufacturing scale-up, and the application of advanced analytical technologies to improve vector characterization, process understanding, and product quality.</blockquote><blockquote>Speaker:&nbsp;Erin M. Panczyk (Principal Scientist, CDMS Program, Waters Corporation)Erin Panczyk is a Principal Scientist at Waters Corporation, supporting the CDMS program at the Immerse Cambridge facility.She advances the scientific and commercial impact of the Xevo CDMS platform by collaborating with academic and industrial partners to characterize large, heterogeneous biomolecules including AAVs, protein complexes, and other biotherapeutics.Previously a Research Scientist at Bruker Scientific, she contributed to the development and commercialization of emerging MS technologies. Her doctoral work focused on native MS instrument development, advancing SID and TIMS methodologies to characterize protein complex architecture and stoichiometry.</blockquote>

Waters Corporation: CDMS in Action: Driving Better AAV Processes and Deeper Viral Vector Insights

CDMS in Action: Driving Better AAV Processes and Deeper Viral Vector Insights

Learn how Waters Xevo CDMS accelerates AAV development. Resolve empty, partial, and full capsids to optimize viral vector manufacturing processes

Waters Xevo CDMS for AAV Characterization

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>Glycoproteomics asks mass spectrometry to solve a difficult problem: capture the heterogeneity that makes glycosylation biologically important without losing the structural information needed to understand it. For O-linked glycopeptides in particular, researchers need to determine where glycans are located, how they are structured, and which glycoforms are present.Join Dr. Nicholas Riley of the University of Washington for a closer look at how new fragmentation capabilities on the Thermo Scientific™ Orbitrap™ Tribrid™ Apex MultiOmics Mass Spectrometer are opening additional ways to investigate this complexity. Drawing on his lab’s work with O-glycopeptides, Riley will explore infrared photoactivation during electron transfer dissociation (IR-ETD) and how it can be combined with collisional activation to generate complementary, information-rich spectra.You’ll see how adjusting IR laser power and collision energy changes the fragmentation information available from the same complex biomolecule. Riley will also discuss the data-analysis challenges created by richer spectra. Attendees will have the opportunity to participate in the live Q&amp;A following the presentation.&nbsp;<h5>Who should attend?</h5>Researchers in glycoproteomics, proteomics, glycobiology, mass spectrometry, PTM analysis, advanced fragmentation methods, and glycopeptide/glycoproteoform characterization.<h5>What you can expect to learn</h5><ul><li>Why O-glycopeptide heterogeneity and site localization remain challenging</li><li>How IR-assisted ETD can provide complementary structural information</li><li>How tuning laser power and collision energy can favor different fragment-ion populations</li><li>Opportunities for glycoproteomics data analysis and informatics</li><li>How complementary ion-ion approaches including PTCR may connect glycopeptide heterogeneity with intact glycoproteoform characterization</li></ul><blockquote>Presenter: Brett Larsen (Sr. Marketing Specialist Proteomics, Thermo Fisher Scientific)Brett Larsen is a leader in chemoproteomics and post-translational modification analysis at Thermo Fisher Scientific. With over 25 years of mass spectrometry experience, he has led proteomics at LTRI Toronto and advanced applications at MDS Proteomics. Brett brings practical expertise in translating complex workflows into real-world discovery.Presenter: Nicholas M. Riley, PhD (Assistant Professor of Chemistry, University of Washington)Dr. Riley earned his PhD in mass spectrometry instrumentation and proteomics at the University of Wisconsin–Madison and completed postdoctoral research with Carolyn Bertozzi at Stanford. He launched the Riley Research Group at the University of Washington in 2023 to study glycosylation using MS-based multi-omics, chemical biology, and bioinformatics.Moderator: Breana Murphy (Regional Marketing Manager LSMS-North America, Thermo Fisher Scientific)</blockquote></div></div></div>

Thermo Fisher Scientific: The Groundbreakers Series: Pushing Boundaries 

Enhancing access to the glycoproteome through advances to the Thermo Scientific™ Orbitrap™ Tribrid™ mass spectrometer platform

Learn how IR-ETD and collisional activation on the Orbitrap Tribrid Apex improve O-glycopeptide characterization, site localization, and structural analysis.

Thermo Scientific Orbitrap Tribrid Apex multiomics MS

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>Metabolomics experiments often face two practical challenges: capturing metabolites across the wide concentration range found in complex biological samples and balancing the different requirements of quantitative and discovery-based analysis. Low-abundance metabolites can be difficult to detect alongside highly abundant compounds, while targeted quantitation and untargeted discovery have traditionally required different analytical approaches.Join this webinar to hear Dr. Bashar Amer share work presented at ASMS exploring how enhanced dynamic range (eDR) on the Thermo Scientific™ Orbitrap™ Excedion™ Mass Spectrometer can help address these challenges. He will explain the principles behind eDR and show how extending effective MS1 dynamic range can improve the recovery and annotation of lower-abundance metabolites in complex biological samples.Using experimental data from plasma and a diet-induced obesity mouse study, Bashar will demonstrate how eDR can increase the number of detectable compounds and acquired MS2 spectra, improve metabolite annotation, and reveal biologically relevant differences. The presentation will also introduce the SQUAD workflow, which brings targeted quantitation and untargeted metabolomics together within a single workflow.Attendees will have the opportunity to participate in the live Q&amp;A following the presentation.&nbsp;<h5>Who should attend?</h5>Metabolomics researchers, LC-MS users, scientists conducting targeted or untargeted metabolomics, researchers interested in Orbitrap MS, core laboratory scientists, analytical scientists, and method developers.<h5>What you can expect to learn</h5><ul><li>How eDR extends effective MS1 dynamic range and improves recovery of lower-abundance metabolites</li><li>How increased metabolome coverage can improve compound annotation</li><li>How eDR compares with traditional full MS1 acquisition</li><li>How SQUAD combines targeted quantitation and untargeted metabolomics</li></ul><blockquote>Presenter: Bashar Amer, PhD (Application Scientist, Thermo Fisher Scientific)Bashar Amer has a background in microbial and nutritional metabolomics as well as developing MS-based analytical assays for food studies. Bashar currently works as an Application Scientist for Thermo Fisher Scientific focusing on developing metabolomics workflows for the simultaneous quantitation and discovery analysis (SQUAD analysis) which is offering researchers a way to strike the balance between untargeted and targeted approaches in one single experiment.Moderator: Breana Murphy (Regional Marketing Manager LSMS-North America, Thermo Fisher Scientific)</blockquote></div></div></div>

Metabolomics without compromises: Extending dynamic range and enabling simultaneous quantitation and discovery in metabolomics using eDR

Learn how eDR on the Orbitrap Excedion extends MS1 dynamic range, improves metabolite annotation, and supports SQUAD targeted and untargeted metabolomics.

Metabolomics without compromises using eDR

<h3>Follow the step-by step the pathway to develop your biotherapeutic peptide</h3>From impurity characterization to regulatory compliance, explore how robust LC and LC-MS workflows help bring biotherapeutic peptides to market faster while ensuring product quality and safety.Join our webinar series which addresses each stage and hear expert discussions on how analytical solutions can help accelerate time to market and speed up regulatory approvals.<h4>Step 2: How Clean Is Your GLP-1?</h4>Purification Strategies for Peptide DevelopmentPurification is more than a manufacturing step. It plays a critical role in product quality, impurity control, and downstream analytical success. Closely related peptide impurities can be difficult to separate, yet their characterization is essential for regulatory compliance.Join us to learn how optimized purification workflows can improve recovery, maximize purity, and simplify downstream analytical challenges.<h5>Why attend?</h5><ul><li>Improve recovery of challenging GLP-1 analogues</li><li>Isolate closely related impurities for characterization</li><li>Obtain higher-purity fractions from limited sample quantities</li><li>Improve efficiency throughout peptide development workflows</li></ul><h5>Key takeaway</h5>Discover how effective purification strategies can reduce analytical risk and accelerate peptide development.<h5>Meet the Expert(s)</h5>Hear from Waters scientists and market experts who work with pharmaceutical manufacturers every day to solve analytical challenges across the entire GLP-1 development lifecycle, from molecule characterization and purification through to QC and regulatory readiness.<blockquote>Speaker:&nbsp;Antonia Wierzbicki (Principal MS Market Development Manager, EMEA, Waters Corporation)Antonia Wierzbicki is Principal Market Development Manager for Pharma in EMEA at Waters Corporation. She leads strategic initiatives focused on therapeutic peptides, GLP-1 receptor agonists, DMPK, and bioanalysis. Working closely with pharmaceutical innovators, CDMOs, and peptide manufacturers, Antonia helps organizations address analytical challenges throughout development and manufacturing. In this session, she will explore purification strategies that enable improved impurity control, greater analytical confidence, and faster GLP-1 development.</blockquote>

How Clean Is Your GLP-1?

Purification strategies for GLP-1 therapeutics that improve recovery, impurity control, fraction purity, and downstream analytical performance.