<p><strong>Post-translational modifications (PTMs) are where so much of biology’s complexity lives, but they are also some of the hardest molecular features to analyze with confidence. Phosphorylation, asymmetric dimethylarginine (ADMA), and O-GlcNAcylation (O-GlcNAc) often occur at low abundance, can be highly labile, and frequently require precise site localization to understand their biological meaning. This</strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/tn_004377_ov_phosphorylation_ptm_etd_excedion_pro_tn004377_na_en_71f681655f.pdf"><strong> technical note </strong></a><strong>shows how the </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1958"><strong>Thermo Scientific Orbitrap Excedion Pro Hybrid Mass Spectrometer</strong></a><strong> helps address those challenges by combining fast, sensitive performance with complementary </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/7217"><strong>HCD and EThcD fragmentation</strong></a><strong> workflows.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Phosphorylation_ADMA_and_O_Glc_N_Ac_Analysis_on_the_Orbitrap_Excedion_Pro_Mass_Spectrometer_d24a5de98e.jpg" alt="Thermo Fisher Scientific: Phosphorylation, ADMA, and O-GlcNAc Analysis on the Orbitrap Excedion Pro Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Phosphorylation_ADMA_and_O_Glc_N_Ac_Analysis_on_the_Orbitrap_Excedion_Pro_Mass_Spectrometer_d24a5de98e.jpg 245w," sizes="100vw" width="1024" height="512"></p><p>Using enriched PTM samples and automated data-dependent acquisition, the study demonstrates that the <strong>Orbitrap Excedion Pro MS</strong> can deliver both depth and confidence across multiple PTM classes. For phosphorylation analysis, the platform identified 5,892 unique phosphosites from IMAC-enriched samples and <strong>2,941 </strong>unique phosphotyrosine sites after phosphotyrosine enrichment, highlighting strong performance for both broad and highly targeted signaling studies. Just as importantly, the data show that HCD and EThcD provide complementary value, with each fragmentation method contributing unique site identifications and helping resolve ambiguous assignments.</p><p>The note also highlights the value of EThcD for more analytically demanding PTMs. In ADMA-enriched samples, EThcD delivered more ADMA peptide-spectrum matches and more unique modified peptides than HCD, supporting improved confidence in site characterization. For O-glycopeptides, the Orbitrap Excedion Pro MS uses an intelligent HCD-product-dependent-EThcD strategy that triggers EThcD only when oxonium ions are detected, improving productivity while preserving the fragmentation detail needed for confident glycosite localization.</p><p>Overall, this technical note shows how <strong>Orbitrap Excedion Pro MS </strong>enables researchers to go deeper into PTM biology with greater sensitivity, better site confidence, and smarter acquisition. For scientists studying signaling, regulation, and disease mechanisms, it presents a powerful approach for expanding PTM coverage without compromising analytical rigor.</p><blockquote><h5><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/tn_004377_ov_phosphorylation_ptm_etd_excedion_pro_tn004377_na_en_71f681655f.pdf"><span><strong>Download the technical note</strong></span> "<strong>Advancing phosphorylation, ADMA, and O-GlcNAc PTM analysis with HCD and EThcD on the Orbitrap Excedion Pro mass spectrometer</strong>"</a></h5></blockquote><p><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong><u>LinkedIn:</u></strong></a>&nbsp;#PTM #OrbitrapExcedionPro #glycosylation #phosphorylation</p>

Phosphorylation, ADMA, and O-GlcNAc Analysis on the Orbitrap Excedion Pro Mass Spectrometer

<p><strong>The countdown is almost over. In just one week, the international chromatography community will meet in Prague for the </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/events/644"><strong>35th International Symposium on Chromatography (ISC 2026)</strong></a><strong>, taking place from September 6–10, 2026. Whether your registration has been confirmed for months or you are still deciding whether to join, now is the time to finalize your plans. Here is what you need to know before ISC 2026 begins.</strong></p><p><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/companies/314"><strong>ISC</strong></a> is the oldest conference series dedicated to separation science, with symposia organized since 1956. This September, the Prague Congress Centre will welcome researchers, industry experts, instrument manufacturers, young scientists, and other specialists for five days of chromatography and separation science, covering everything from fundamental research to pharmaceutical, environmental, food, health, and omics applications.</p><p>But before the scientific sessions begin, there are a few practical details worth checking.</p><h4><strong>ISC officially starts on September 6 – but activities begin a day earlier</strong></h4><p>The official dates for ISC 2026 are <strong>Sunday, September 6 through Thursday, September 10</strong>, but for some participants the conference starts already on <strong>Saturday, September 5</strong>.</p><p>The first <strong>Short Courses </strong>are scheduled for Saturday (<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/6770"><strong>SC 1 – Modern HPLC Separation in Theory and Practice</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7312"><strong>SC 2 – mzmine for LC-MS data analysis</strong></a>), with additional courses continuing on Sunday morning and afternoon. If you have registered for a Short Course, make sure to check its exact date and starting time before arranging your journey to Prague.</p><p>Sunday then marks the official opening of ISC 2026, with the <strong>Opening Ceremony, Award Ceremony, </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7361"><strong>plenary lectures</strong></a><strong>, and Welcome Reception</strong> introducing delegates to the week ahead.</p><h4><strong>Haven’t registered yet? You can still join ISC 2026</strong></h4><p>Missed the late-registration deadline? It is <strong>still possible to attend</strong>.</p><p>Onsite registration has been available since <strong>August 26, 2026</strong>, giving last-minute participants another opportunity to join the symposium. Current onsite registration fees are:</p><ul><li><strong>Industry:</strong> €1,150</li><li><strong>Academic:</strong> €890</li><li><strong>Student:</strong> €390</li><li><strong>Short Courses:</strong> €270</li></ul><p>The Short Course fee covers participation in up to three Short Courses.</p><p>One practical point for last-minute registration: bank-transfer payments closed on August 19, so <strong>only card payments are now accepted</strong>.</p><p>Full registration includes access to oral and poster sessions, the exhibition, the Sunday Welcome Reception, scheduled lunches and coffee breaks, the electronic Book of Abstracts, and a <strong>Prague public transportation pass</strong>.</p><h4><strong>Where is ISC 2026 and how do you get there?</strong></h4><p>ISC 2026 will take place at the:</p><p><strong>Prague Congress Centre</strong></p><ul><li>5. května 65</li><li>140 21 Prague 4</li><li>Czech Republic</li></ul><p>The venue is particularly easy to reach by public transport. It is located directly on Prague’s <strong>Metro Line C at Vyšehrad station</strong>, just around five minutes by metro from Muzeum station in the city centre.</p><p>The Prague Congress Centre brings the lecture halls, exhibition spaces, meeting rooms, and other conference facilities together in one venue, making it easy to move between scientific sessions, posters, industry activities, and the exhibition throughout the day.</p><p>And since full conference registration includes public transportation in Prague, getting around the city during ISC should be straightforward.</p><h4><strong>When can you pick up your conference materials?</strong></h4><p>The registration desk will already be open during the Short Courses and will remain available throughout the symposium.</p><p><strong>Registration opening hours:</strong></p><ul><li><strong>Saturday, September 5:</strong> 8:30–17:00</li><li><strong>Sunday, September 6:</strong> 7:30–19:00</li><li><strong>Monday, September 7:</strong> 7:30–18:00</li><li><strong>Tuesday, September 8:</strong> 7:30–19:00</li><li><strong>Wednesday, September 9:</strong> 8:00–18:00</li><li><strong>Thursday, September 10:</strong> 8:30–14:30</li></ul><p>If you are arriving in Prague on Sunday, allowing some extra time for registration before the Opening Ceremony will make the start of the conference considerably more relaxed.</p><h4><strong>Now is the time to build your personal ISC program</strong></h4><p>With several parallel sessions running throughout the week, trying to decide where to go only after arriving at the venue may mean missing something important.</p><p>The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7477"><strong>main scientific program</strong></a> is organized around three broad areas:</p><ul><li><strong>Fundamentals</strong></li><li><strong>Bioanalysis and omics applications</strong></li><li><strong>Hyphenated techniques</strong></li></ul><p>These are complemented by <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7280"><strong>Tutorials </strong></a><strong>+ Young Speakers</strong>, plenary and invited lectures, poster sessions, the international exhibition, vendor seminars, and industry-focused activities.</p><p>Before leaving for Prague, take another look at the <strong>Interactive Program</strong> and mark the lectures, posters, and other activities that are most relevant to you. If you are presenting your own work, this is also the right time to double-check your assigned session, room, and presentation time.</p><p>And don’t focus only on the oral program. <strong>Poster sessions and exhibition breaks</strong> are among the best opportunities to discuss new research directly with authors, meet instrument and technology specialists, and make new contacts.</p><h4><strong>Don’t overlook the vendor seminars and industry program</strong></h4><p>ISC 2026 is not limited to academic presentations. The conference also includes an extensive industry component, with activities covering current challenges in separation science and practical applications of new analytical technologies.</p><p>During the lunchtime sessions, participants can attend <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7736"><strong>vendor seminars</strong></a> presented by companies including <strong>Avantor, Shimadzu, Advanced Materials Technology, Restek, and Thermo Fisher Scientific</strong>. Topics range from stationary-phase selectivity and chromatographic modelling to HPLC and LC-MS column technologies and advanced characterization of biotherapeutics.</p><p>The conference also includes dedicated <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7777"><strong>Industry Activities</strong></a> <strong>from Monday through Wednesday</strong>, bringing together academic and industrial perspectives on topics relevant to analytical laboratories and the future of separation science. One of the discussions, for example, will examine how education in separation science can better reflect the skills required by modern industry, while another will focus on sustainability and the practical implementation of greener analytical workflows.</p><p>On Wednesday, participants can also join the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7801"><strong>Publishing Workshop</strong></a>, another activity worth adding to the schedule if scientific publishing is part of your work.</p><h4><strong>Test your chromatography knowledge at the ISC Quiz</strong></h4><p>Not every session needs to be completely serious.</p><p>On <strong>Tuesday, September 8 from 18:30 to 19:30</strong>, ISC will host an interactive <strong>Chromatography Quiz</strong>, combining practical questions, chromatography fundamentals, unusual facts, and lighter challenges.</p><p>There is <strong>no advance registration required</strong>. Any registered conference participant can join, but remember to bring a smartphone—the quiz uses live participation through a QR code.</p><p>Results will be scored in real time, and prizes will be awarded to the <strong>top three participants</strong>.</p><h4><strong>Start networking from the first evening</strong></h4><p>The scientific program may be the main reason to attend ISC, but the conversations between sessions can be equally valuable.</p><p>The first major networking opportunity comes immediately on Sunday.</p><p>The <strong>Welcome Reception</strong> will take place on <strong>September 6 from 18:30 to 20:00</strong> in the second-floor foyer of the Prague Congress Centre. It is open to registered participants and accompanying persons and includes a light buffet and drinks.</p><p>As it takes place immediately after the opening program, it is an ideal opportunity to reconnect with colleagues, meet new contacts, and start conversations before the full parallel scientific program begins on Monday.</p><p>Another social highlight will be the <strong>Gala Dinner on Wednesday, September 9 from 19:00 to midnight</strong> at the National House Vinohrady.</p><p>The Gala Dinner requires a separate <strong>€100 ticket</strong>, is not included in the standard registration fee, and has a smart-casual dress code. Participants should also note that transportation to and from the venue is not organized by the conference.</p><h4><strong>And perhaps leave a little time for Prague</strong></h4><p>A conference schedule can fill up quickly, but ISC 2026 is taking place in one of Europe’s most walkable cities.</p><p>If you find some free time between sessions, <strong>Vyšehrad is only about a 10-minute walk from the Prague Congress Centre</strong> and offers panoramic views across Prague and the Vltava River. It is an easy option for a short walk without travelling back into the historic city centre.</p><p><strong>See you at ISC 2026 in Prague!</strong></p>

ISC 2026 Starts in One Week: What You Need to Know

<p><strong>In the week of August 31, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Technology Networks: Modern Methods for Faster Microbial Analysis</strong></h5><ul><li>Tu, 1.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6454">Registration</a></li></ul><p>Struggling to choose the right technique for microbial testing? Learn how MALDI-TOF, FTIR, and automated DNA/RNA electrophoresis accelerate identification.</p><h5><strong>2. Phenomenex: Addressing LC Method Optimization - Scaling For Efficiency, Throughput And Reproducibility</strong></h5><ul><li>We, 2.9.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6458">Registration</a></li></ul><p>Join this webinar on LC method optimization and scaling. Learn how column dimensions, particle morphology, and sample loading strategies maximize throughput and reproducibility.</p><h5><strong>3. Thermo Fisher Scientific: Proteoform Studio software, top down made simple</strong></h5><ul><li>We, 2.9.2026 14:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6459">Registration</a></li></ul><p>Learn how Thermo Scientific Proteoform Studio software simplifies top-down MS and intact protein analysis through integrated workflows, interactive deconvolution, and reporting.</p><h5><strong>4. Agilent Technologies: Targeted Hybridization Capture for Antimicrobial Resistance Surveillance in Complex Environmental Samples</strong></h5><ul><li>We, 2.9.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6455">Registration</a></li></ul><p>Discover how Agilent SureSelect hybrid capture enhances antimicrobial resistance gene detection and characterization in complex environmental samples compared with shotgun NGS.</p><h5><strong>5. Thermo Fisher Scientific: Ask the Expert: What to expect from the new Thermo Scientific™ Orbitrap™ Excedion™ Hybrid mass spectrometers</strong></h5><ul><li>Th, 3.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6466">Registration</a></li></ul><p>Discover the new Orbitrap Excedion Hybrid Mass Spectrometer and learn how enhanced dynamic range, robust performance, and an upgradeable design support advanced HRAM workflows.</p><h5><strong>6. Waters Corporation: Informatics series #34 Ready for Self-Documenting Chromatography?</strong></h5><ul><li>Th, 3.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6426">Registration</a></li></ul><p>Speed up root cause analysis with self-documenting LC and Empower software in this 30-minute Waters coffee break.</p><h5><strong>7. SciY/Mestrelab Research: From Legacy Workflows to Paperless Labs: Track Every Sample, Process, and Decision</strong></h5><ul><li>Th, 3.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6425">Registration</a></li></ul><p>Transform your lab from paper to digital. Learn how WebLab and LIMS workflows automate sample tracking and support laboratory compliance.</p><h5><strong>8. SelectScience: ADC characterization in one native LC-MS workflow</strong></h5><ul><li>Fr, 4.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6460">Registration</a></li></ul><p>Simplify ADC characterization with native RP-LC-MS using Biozen® columns to determine DAR, proteoforms, and positional isomers without buffer exchange.</p>

Webinars LabRulezLCMS Week 36/2026

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The International Symposium on Chromatography (ISC) represents the oldest conference series focussing on separation science. ISC symposia have been organised since 1956 in each even year. ISC is internationally recognised as one of the premier meeting series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.

International Symposium on Chromatography - (ISC)

Agilent Technologies

SCIEX

Waters Corporation

<div><h4><strong>Navigating Challenges and Opportunities for Environmental Testing Labs Under the Revised EU Water Framework Directive</strong></h4><p><strong>The European Commission’s proposed updates to the Water Framework, Groundwater, and Environmental Quality Standards Directives are bringing new responsibilities and opportunities for environmental testing labs. With expanded pollutant lists - including PFAS, pharmaceuticals, and pesticide metabolites - and stricter monitoring and reporting requirements, the landscape of water analysis is rapidly evolving.</strong></p><p>Join the 4th Waters Environmental Webinar Series to explore how your lab can navigate these challenges and turn regulatory change into opportunity.</p><p>Register for free and partner with us to shape the future of European water quality.</p><h5><strong>Why Attend</strong></h5><p>Stay ahead of new EU regulatory demands with insights from leading experts. Gain practical guidance, share experiences with peers, and prepare your lab for the next generation of water quality standards.</p><h5><strong>Highlights</strong></h5><ul><li>New pollutant categories and analytical challenges</li><li>Updates to monitoring protocols and reporting</li><li>Innovative methods to meet revised Environmental Quality Standards</li><li>Strategic guidance for compliance and adaptation</li></ul><p><strong>Lead the change in water analysis—stay ahead, stay compliant, and make a real impact.</strong></p><h4><strong>EPISODE 6: Blue Thursdays 2026 – The Best Of</strong></h4><p>In this final session, we’ll look back at the most important things we’ve learned throughout the Blue Thursday series. We’ll explore the big trends we’re seeing, the smart tools scientists use to study the environment, and what exciting developments will be coming next.</p><blockquote><p><strong>Speaker:</strong> Claudia Rathmann (Principal F&amp;E Market Development Manager, Waters Corporation)</p><p>Experienced and passionate analytical science professional with over 20 years of technical and strategic expertise in food and environmental applications. Currently serving as Principal Market Development Manager at Waters Corporation, Claudia specializes in connecting customers with product management to deliver innovative solutions for complex analytical challenges. With a strong scientific foundation and a proven track record in both technical and marketing roles, Claudia bridges the gap between customer needs and product innovation across the EMEA region.</p><p><strong>Speaker: </strong>Janitha De-Alwis (JD) (Principal F&amp;E Market Development Manager, Waters Corporation)</p><p>Janitha De-Alwis (known as JD) is an applications chemist in the European demo lab, based in Wilmslow, UK. His main role focuses on application development work for the food and environmental sector. JD takes great pride in speaking to, and advising, many food and environmental customers. His position requires him to be reactive and proactive to the changes in the food industry, such as changing regulations, topical issues and food safety risks.</p></blockquote></div>

Blue Thursdays 2026 – The Best Of

In this final session, we’ll look back at the most important things we’ve learned throughout the Blue Thursday series.

<p><strong>Size exclusion chromatography (SEC) is an essential technique for separating and characterizing biomolecules and polymers based on hydrodynamic size, enabling applications such as aggregate analysis of therapeutic proteins, assessment of viral vectors and nucleic acid therapeutics, and molecular‑weight profiling of synthetic polymers.</strong></p><p>In this webinar, we will present a streamlined SEC workflow using Agilent LC platforms alongside Agilent’s full portfolio of SEC column solutions. The session will highlight performance characteristics, application fit, and best-practice method setup for multiple Agilent SEC columns—including our most advanced column technologies designed for high efficiency, minimal secondary interactions, and dependable robustness across complex sample types. Attendees will gain practical guidance on selecting the right column for their application, optimizing isocratic SEC conditions, and achieving reproducible, high-resolution separations in both R&amp;D and QC environments.&nbsp;</p><blockquote><p><strong>Speaker:</strong> Mohit Patel (Application Engineer, Agilent Technologies, Inc.)</p><p>Mohit Patel is part of the CSD Online AE Team. His primary focus is to support SMLC, Bio-Columns, and consumables.</p><p>Before joining Agilent, Mohit was an Assistant Professor of Chemistry at Temple University. Mohit developed his passion for science through his experiences as a faculty researcher and a mentor. Mohit actively taught, developed curriculum, and served as senior personnel, with a leadership position, on funded grants, mentored research projects, and co-coordinator of STEAM related outreach services.</p><p>Mohit has earned a Doctorate degree in Chemistry from Temple University in 2016.</p></blockquote>

Agilent Technologies: Becoming A Better Chromatographer Webinar Series

Comprehensive SEC Solutions: Performance and Application Insights Across Agilent’s SEC Columns

Explore Agilent's SEC column portfolio. Learn best practices for high-resolution aggregate analysis, viral vector sizing, and polymer profiling

Comprehensive SEC Solutions: Agilent Column Performance

<p><strong>If your goal is to maximize instrument uptime, then maintaining a well-stocked lab is your first step. Preventive maintenance is the key to minimizing instrument downtime. In this webinar, we will discuss which tools, supplies, and resources you should have on hand to maintain your instrument. Even with the best maintenance, sometimes instruments and methods need troubleshooting. This webinar will also discuss which resources and supplies can simplify your troubleshooting.</strong></p><blockquote><p><strong>Speaker:</strong> Melissa Goodlad (Application Engineer, Agilent Technologies, Inc.)</p><p>Melissa Goodlad is an Application Engineer providing applications assistance and technical support for Agilent’s HPLC columns and consumables. Before joining Agilent, Melissa was completing her PhD in Physical Chemistry at UC Merced studying nanoparticle self-assemblies.</p></blockquote>

Stocked for Success: Resources and Supplies to Minimize HPLC Downtime

Keep your lab stocked for success. Explore essential HPLC tools, troubleshooting resources, and preventative maintenance tips to maximize system uptime

Minimize HPLC Downtime: Essential Resources & Supplies

<p><strong>This webinar presents the benefits of hyphenated ion chromatography (IC) with inductively coupled plasma mass spectrometry (ICP-MS). Practical examples, such as chromium speciation according to ISO 24384, are discussed.</strong></p><blockquote><p><strong>Presenter:</strong> Andrew Brotherhood (Application Engineer, Agilent Technologies, Inc.)</p><p>Andrew Brotherhood has over 20 years of experience with ICP-MS, ICP-OES and Ion Chromatography instrumentation. He has mainly worked in the pharmaceutical analysis industry gaining significant experience with developing and validating methods to pharma regulations. Andrew started working for Agilent in 2018 as an Atomic Spectroscopy Application Specialist based at the Agilent Centre of Excellence in the UK.</p></blockquote><blockquote><p><strong>Presenter:</strong> Dr. Elke Suss (Application Specialist, Metrohm)</p></blockquote>

Agilent Technologies: Speciation of Chromium by IC-ICP-MS

Speciation of Chromium by IC-ICP-MS

Learn chromium speciation using hyphenated IC-ICP-MS. Explore practical workflows and achieve ISO 24384 compliance in this expert webinar

Chromium Speciation via IC-ICP-MS | ISO 24384 Analysis

<h4><strong>LC Coffee Breaks Free Webinar Series</strong></h4><p>Each episode focuses on answering a specific challenge faced by chromatographers, helping you improve efficiency, solve problems faster, and stay up to date with the latest trends in Liquid Chromatography.</p><h4><strong>Episode 3</strong></h4><h4><strong>From RI to CAD: How Universal LC Detectors Compare in Real World Performance</strong></h4><h5><strong>What will you learn</strong></h5><ul><li>Gain practical understand on detectors ideal use cases</li><li>Learn how to select the right universal detector to improve your analysis</li></ul><h5><strong>Why you should attend</strong></h5><ul><li>Get practical, users insights you can immediately apply in your daily LC laboratory work.&nbsp;</li><li>In just a short coffee-break session, you'll gain valuable tips on troubleshooting, method development, method transfer, technology updates, column chemistries, and real-world applications.</li></ul><blockquote><p><strong>Speaker: </strong>Pawel Bigos (Senior Scientist, Waters Corporation)</p><p>Pawel Bigos is a Senior Scientist at Waters Corporation in the QA/QC Biologics group in Milford, Massachusetts. He holds a Bachelor of Science degree in Chemistry from the University of South Florida. Prior to Waters, Pawel gained valuable experience at Frequency Therapeutics, Novartis, and Symbiotic Research. Since joining Waters in 2022, he has concentrated on biomolecule separations and plays a critical role in providing analytical support in the development, commercialization, and application of Waters innovative products.</p></blockquote>

LC Coffee Breaks: From RI to CAD: How Universal LC Detectors Compare in Real World Performance

Compare universal LC detectors from RI to CAD. Discover practical use cases and select the right detector for your analyses in this Waters webinar

From RI to CAD: Universal LC Detectors Compared

<h4><strong>LC Coffee Breaks Free Webinar Series</strong></h4><p>Each episode focuses on answering a specific challenge faced by chromatographers, helping you improve efficiency, solve problems faster, and stay up to date with the latest trends in Liquid Chromatography.</p><h4><strong>Episode 4</strong></h4><h4><strong>Why My Method Doesn't Transfer Smoothly?</strong></h4><h5><strong>What will you learn</strong></h5><p>Method transfer issues can lead to delays, inconsistent data, and costly rework. Join this webinar to:</p><ul><li>Understand the root causes of transfer failures</li><li>Learn best practices for achieving reliable, reproducible liquid chromatography methods across different systems and environments</li></ul><h5><strong>Why you should attend</strong></h5><ul><li>Get practical, users insights you can immediately apply in your daily LC laboratory work.&nbsp;</li><li>In just a short coffee-break session, you'll gain valuable tips on troubleshooting, method development, method transfer, technology updates, column chemistries, and real-world applications.</li></ul><blockquote><p><strong>Speaker: </strong>Norris Wong (Senior Evaluation Scientist, Waters Corporation)</p><p>Norris Wong is a Senior Evaluation Scientist at Waters Corporation from the Validation and Competitive Analysis Group in the LC-MS business unit. He graduated from Bowdoin College with a degree in Biochemistry. Prior to Waters, he worked in the pharmaceutical industry at a CRO, performing cGMP and R&amp;D extractable/leachable analysis using LC and GC instruments. His current work at Waters focuses on evaluating LC system performance and method transfer across LC systems with compendial methods.</p></blockquote>

LC Coffee Breaks: Why my Method Doesn't Transfer Smoothly?

Learn why LC method transfer fails and how to fix it. Discover best practices for seamless method transfer across instruments in this Waters webinar

Why LC Method Transfer Fails & How to Fix It

<div><h4><strong>DAWN MALS for Proteins and Gene Therapy</strong></h4><p><strong>As biotherapeutics become increasingly complex, comprehensive characterization is essential for understanding critical quality attributes and ensuring product quality. Multi-Angle Light Scattering (MALS) is a powerful analytical technique that provides direct, absolute measurements of multiple molecular attributes in a single experiment, including molar mass, size, conformation, aggregation, and conjugation.</strong></p><h5><strong>Why you should attend</strong></h5><p>This webinar introduces the fundamentals of MALS and highlights its application to the characterization of biotherapeutics such as monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), protein conjugates, and adeno-associated viruses (AAVs).</p><p>Attendees will learn how coupling MALS with separation techniques such as SEC enables comprehensive molecular characterization without reliance on calibration standards or molecular assumptions. Through real-world examples, the webinar will demonstrate how MALS helps scientists gain deeper insight into molecular structure, composition, and heterogeneity throughout biotherapeutic development.</p><ul><li>Understand the principles of Multi-Angle Light Scattering (MALS)</li><li>Learn how MALS provides comprehensive characterization of biotherapeutics in a single analysis</li><li>Explore applications for determining molar mass, size, conformation, aggregation, and conjugation</li><li>Discover how MALS supports the development and characterization of mAbs, ADCs, protein conjugates, and AAVs</li></ul><h4><strong>Who should attend?</strong></h4><ul><li>Scientists, Analysts, and Lab Managers in Discovery, Development, Quality Control, or Analytical Services who characterize antibodies, ADCs, and other protein therapeutics.</li><li>CDMO, CRO and other testing organization who are interested in expanding their capabilities</li></ul><blockquote><p><strong>Presenter:&nbsp;</strong>Udayabagya (Bud) Halim (Sr. Product Marketing Analyst, Waters Corporation)</p><p>Bud Halimis a senior marketing analyst at Waters | Wyatt Technology with a PhD in physical chemistry from UCLA.</p><p>He began his career teaching biochemistry and chemistry and contributing to laboratory manuals before transitioning into the scientific instrumentation industry as an applications scientist.</p><p>At Waters, he supports researchers in the characterization of peptides, biologics, lipid nanoparticles (LNPs), and viral vectors.</p></blockquote></div>

Waters Corporation: Applications of Multi-Angle Light Scattering for Biotherapeutic Characterization

Applications of Multi-Angle Light Scattering for Biotherapeutic Characterization

Master biotherapeutic characterization with DAWN MALS. Learn how SEC-MALS delivers absolute molar mass and aggregation data for mAbs, ADCs, and AAVs

DAWN MALS for Biotherapeutic & Gene Therapy Analysis

<p><strong>The objective of this webinar is to demonstrate how the ZenoTOF 8600 system enables advanced, reliable, and high-throughput analysis for food safety and environmental testing.</strong></p><h4><strong>Participants will gain an understanding of how to:</strong></h4><ul><li>Achieve ultra-sensitive quantitation and confident identification of contaminants in complex matrices</li><li>Apply high-resolution workflows for quantitation and screening applications</li><li>Improve data quality, throughput, and regulatory compliance in routine laboratories</li><li>Leverage the capabilities of the ZenoTOF 8600 system to address emerging analytical challenges such as trace-level contaminants, unknown screening, and large multi-residue panels</li></ul><h4><strong>Key learning points</strong></h4><p>Participants will learn how to:</p><ul><li>Leverage ZenoTOF 8600 system capabilities</li><li>Perform advanced screening and quantitation workflows</li><li>Optimize workflows for food and environmental samples</li><li>Improve data quality and confidence</li><li>Enhance laboratory productivity</li><li>Address emerging analytical challenges: Ultra-trace detection (ppt levels) and non-target screening, and retrospective data analysis</li></ul><h4><strong>Who should attend</strong></h4><p>This webinar is designed for professionals involved in food safety and environmental analysis, including:</p><ul><li>Analytical scientists and chemists</li><li>Working with LC-MS/MS or high-resolution MS in routine or research laboratories</li><li>Laboratory managers and supervisors</li><li>Looking to improve lab efficiency, throughput, and analytical capabilities</li><li>QA/QC professionals</li><li>Responsible for ensuring data quality, compliance, and regulatory standards</li><li>Food safety specialists</li><li>Involved in testing for pesticides, mycotoxins, veterinary drugs, and contaminants</li><li>Environmental analysts</li><li>Focused on monitoring PFAS, pharmaceuticals, pollutants, and emerging contaminants</li><li>Contract testing laboratories (CROs)</li><li>Seeking high-throughput, multi-residue screening capabilities</li><li>Researchers and method developers</li><li>Interested in advanced HRMS workflows and non-target screening.</li></ul><p><i>We will send you a recording of the event</i></p><blockquote><p><strong>Speaker: </strong>Dr. Jianru Stahl-Zeng (Senior Market Development Manager, SCIEX)</p><p>Jianru has been part of SCIEX since 2001. She initially was part of the application support team and covered not only proteomics, but also small molecules applications. Jianru moved to technical marketing and focused on food and environmental applications. Since 2018 she has been managing the EMEA technical marketing team and projects. Jianru is also the Global Technical Leader for food and environmental applications. On January 2026, she took the role of Senior Market Development Manager, FEF, EMEAI.</p></blockquote>

SCIEX: Tackling emerging contaminants in food and water using the ZenoTOF 8600 system

Tackling emerging contaminants in food and water using the ZenoTOF 8600 system

Master emerging contaminant analysis in food and water. Discover how the SCIEX ZenoTOF 8600 delivers ppt sensitivity, screening, and high throughput.

SCIEX ZenoTOF 8600: Emerging Contaminants in Food & Water

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Missed the International Symposium on Chromatography 2026? Explore our posters and talks now.</strong></p><h4><strong>Practical aspects and advantages of coupling ion exchange chromatography to mass spectrometry for biotherapeutic analysis</strong></h4><p>Based on Ken Cook’s ISC 2026 talk, this expanded webinar will explore the practical aspects and advantages of directly coupling ion exchange chromatography to high-resolution mass spectrometry for biotherapeutic analysis.</p><p>The session will highlight how pH gradient elution with volatile, low ionic strength buffers can improve the analysis of monoclonal antibodies, fusion proteins, and PMOs, while avoiding the need for fraction collection and desalting.</p><p>Attendees will also learn about the key method development considerations that influence performance, including buffer selection, pH control, and column choice.</p><p>The talk will further demonstrate how direct ion exchange-MS can deliver high sensitivity, clean deconvolution, impurity detection, and GLP-ready quantitation in a streamlined workflow.</p><h5><strong>Key learnings</strong></h5><ul><li>Understand the principles and practical setup of direct ion exchange-MS for biotherapeutic analysis.</li><li>Learn how volatile, low ionic strength buffers support pH gradient separations compatible with MS.</li><li>See how buffer and column selection affect separation quality, sensitivity, and reproducibility.</li><li>Learn how the workflow applies to mAbs, fusion proteins, and PMOs.</li><li>Understand how direct coupling can improve impurity detection, deconvolution, and quantitation in regulated workflows.</li></ul><h5><strong>Audience</strong></h5><p>This webinar is intended for scientists and analysts working in biopharmaceutical characterization, protein analytics, oligonucleotide therapeutics, method development, and regulated analytical environments. It will be especially relevant for those working on charge variant analysis, intact protein characterization, impurity profiling, and GLP-compliant workflows.</p><p><i>If you are unable to attend the live webinar, please register to automatically receive a link to the on-demand recording.&nbsp;</i></p><blockquote><p><strong>Presenter: </strong>Dr. Ken Cook (BioPharma Applications Support Expert, Thermo Fisher Scientific)</p><p>Moved to industry from a University lectureship in Biochemistry, University of Newcastle upon Tyne, following 7 years’ experience in academia. Now with over 35 years’ experience with Thermo Fisher Scientific using a wide range of analytical equipment and software. Publications range from metabolomics, proteomics to large biopharmaceutical drug analysis. Current job title is the European manager for the BioPharma expert support group. This involves the support of Bio-Pharmaceutical applications to characterise protein and oligonucleotide based bio-therapeutics. This involves ongoing collaborations with the Biopharmaceutical industry and academia. Characterization methods of Bio-therapeutics include, monoclonal antibodies, peptides, AAV analytical development, small and large RNA analysis including sequence mapping of mRNA by LC/HRMS.</p></blockquote></div></div></div>

Thermo Fisher Scientific: Practical aspects and advantages of coupling ion exchange chromatography to mass spectrometry for biotherapeutic analysis

Practical aspects and advantages of coupling ion exchange chromatography to mass spectrometry for biotherapeutic analysis

Learn direct ion exchange chromatography-mass spectrometry (IEX-MS) for biotherapeutics. Streamline mAb, fusion protein, and PMO analysis using pH gradients.

Direct IEX-MS Coupling for Biotherapeutic Analysis

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Missed the International Symposium on Chromatography 2026? Explore our posters and talks now.</strong></p><h4><strong>A novel monodisperse supermacroporous reversed-phase platform for comprehensive nucleic acid analysis across a broad size range</strong></h4><p>Nucleic acid therapeutics span a wide size range, from short oligonucleotides and siRNA to larger sgRNA, tRNA, and mRNA molecules, creating different chromatographic challenges across workflows. Based on the ISC 2026 poster, this webinar will show how a novel monodisperse supermacroporous reversed-phase platform can provide high-resolution separation across this broad range, with improved impurity resolution, consistent performance, and strong lot-to-lot reproducibility. &nbsp;The session will also highlight the platform’s broad applicability for routine nucleic acid analysis, including compatibility with volatile ion-pairing conditions for intact RNA characterization, and the benefits of low carryover for routine analytical use.</p><h5><strong>Key learnings:</strong></h5><ul><li>Understand why nucleic acid therapeutics require different analytical solutions across size ranges.</li><li>See how a monodisperse supermacroporous reversed-phase column supports analysis from short oligos to mRNA.</li><li>Learn how the platform improves peak shape, impurity resolution, and selectivity for nucleic acid samples.</li><li style="color:rgb(0, 0, 0);">Explore the platform’s compatibility with volatile ion-pairing conditions for intact RNA characterization.</li><li>Review evidence for low carryover and strong lot-to-lot reproducibility.</li></ul><h5><strong>Audience:</strong></h5><p>This webinar is intended for scientists and analysts working in biopharmaceutical characterization, method development, oligonucleotide analytics, and RNA analysis. &nbsp;</p><p><i>If you are unable to attend the live webinar, please register to automatically receive a link to the on-demand recording.&nbsp;</i></p><blockquote><p><strong>Presenter: </strong>Matas Damonskis-Roka (HPLC Consumables R&amp;D Manager, Thermo Fisher Scientific)</p><p>Matas Damonskis-Rokas is an HPLC Consumables R&amp;D Manager at Thermo Fisher Scientific, focusing on the development of new chromatography products and applications.</p></blockquote></div></div></div>

Thermo Fisher Scientific: A novel monodisperse supermacroporous reversed-phase platform for comprehensive nucleic acid analysis across a broad size range

A novel monodisperse supermacroporous reversed-phase platform for comprehensive nucleic acid analysis across a broad size range

Analyze nucleic acids from oligos to mRNA with a monodisperse supermacroporous RP platform. Discover high-resolution separations and LC-MS compatibility