Czech researchers from Charles University, Prague, led by Pavla Eliášová, have developed an advanced photocathode that helps convert the greenhouse gas carbon dioxide into pure ethanol using sunlight. The new technology solves a long-standing problem of material degradation in water, achieves record conversion efficiency, and opens the way toward sustainable production of green fuels.Converting carbon dioxide (CO2) into useful fuels using solar energy represents the holy grail of modern green chemistry. The device enabling this conversion is called a solar reactor. Its key element is a photocathode: a material that absorbs light and enables the chemical reaction. Cuprous oxide long appeared to be an ideal material because it is inexpensive, readily available, and excels at capturing solar rays. In practice, however, it faced a fundamental obstacle: in an aqueous environment under light, it transforms and degrades extremely rapidly—much like iron undergoing swift corrosion—and loses its functionality within just tens of minutes.The team from the Chemistry Section of the Faculty of Science, CU, led by Pavla Eliášová, in collaboration with Tomáš Hrbek from the Faculty of Mathematics and Physics, CU, resolved this issue by creating a unique "nano-sandwich". The scientists combined cuprous oxide with advanced two-dimensional materials called MXenes and, through precisely controlled heating, created an ultrathin layer of titanium dioxide on their surface. MXene modified in this way can rapidly drain electric charge from the cuprous oxide, thereby slowing down its decomposition. At the same time, it uses the charge further to convert carbon dioxide into liquid fuel."Surface-engineered MXene combined with cuprous oxide allowed us to unite the best of both materials. The copper base enables maximum utilization of light energy, while the conductive MXene framework ensures that the material remains active even after many hours of operation," explains research team leader Pavla Eliášová from the Chemistry Section of the Faculty of Science, Charles University.In laboratory tests, the new photocathode achieved a record solar-energy-to-ethanol conversion efficiency of 2,74 %. A crucial improvement is the formation of only a single product. While other systems often produce a mixture of byproducts, the material designed by the research team produces pure ethanol as its sole liquid product, which significantly simplifies its potential industrial application."This is a major step forward for us. On our laboratory scale, the system works very well and produces ethanol over many hours. In the next step, we want to further reinforce the stability of the entire photocathode and begin testing on a larger scale and under real daylight conditions," adds physical chemist Pavla Eliášová.The research was conducted within the international European project DESIRED (Horizon Europe), with support from the Charles University Research Centre (UNCE) and the L'Oréal-UNESCO For Women in Science program.<blockquote><h4>Article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/aenm.71469">Surface-Engineered Ti3C2Tx MXene/Cu2O Photocathodes for Highly Selective Photoelectrocatalytic CO2 Reduction to Ethanol</a></h4>Luis A. M. Carrascosa, Magdaléna Linková, Monika Remzová, Tomáš Hrbek, Pavla EliášováAdv. Energy Mater., 2026, 16, e71469<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/aenm.71469">https://doi.org/10.1002/aenm.71469</a><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>Cu2O is an inexpensive p-type semiconductor that promotes the photoelectrocatalytic CO2 reduction reaction (PEC CO2RR). While its low bandgap enables photoexcitation by visible light, long-term stability remains limited due to quick charge recombination and photocorrosion. Here, we enhanced charge separation and extraction by combining Cu2O with surface-engineered MXenes. In this novel architecture, TiO2 grows in situ on the surface of Ti3C2Tx and serves as a charge-transport layer, forming a junction with Cu2O. On the other side, the outer TiO2 surface exposed to the CO2-saturated electrolyte offers catalytically active sites for CO2 reduction. Acting as a central layer, the MXene conductive backbone provides an electronically continuous pathway for electron transport. In PEC CO2RR, the photocathode containing 50 wt.% of MXene and a balanced amount of TiO2 on the Ti3C2 surface outperformed the best Cu/CuxO-based systems operating in non-organic electrolytes reported in the literature. The FTO/Cu2O/ml-Ti3C2Tx-350-N2 photocathode reached 8.4&nbsp;µmol&nbsp;cm−2 h−1 ethanol production rate and 2.74% solar-to-ethanol efficiency after 2&nbsp;h. Moreover, pairing TiO2-MXene with Cu2O significantly stabilized the photocathode, which maintained 76% of the ethanol production rate after 6 h. Overall, our results establish surface-engineered Cu2O/TiO2-MXene heterostructures as a solid platform for highly selective, visible-light-driven ethanol production with significantly improved operational stability.

Researchers from Charles University, Prague, Have Developed a New Photocathode for Efficient Conversion of CO2 into Ethanol

News from LabRulezLCMS Library - Week 42, 2026

Autumn has already turned the leaves into vibrant shades, and with the end of the year approaching, we would like to thank you - before the first snowflakes arrive - for your trust, cooperation, and continued interest in our products and services.As a long-standing distributor of Thermo Scientific Finnpipette products, we know that the accuracy and reliability of laboratory results often begin with seemingly small details. Choosing the right pipette and tip is one of the first steps toward a successful analysis.That is why we have prepared an EXCLUSIVE offer to help you replenish your laboratory supplies at a more attractive price, while also thanking you for your continued cooperation and trust.<blockquote>EXCLUSIVE OFFER valid until the end of 2026<ul><li>10% off tips</li><li>10% off pipettes</li></ul>Enter the code “KAŠTANY” in your order or include it in your order e-mail.*For larger orders, an additional discount may be available.</blockquote><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/analytika_pipety_a_spicky_thermo_20c5943161.jpg" alt="analytika: Thermo Scientific Pipettes and Tips" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_analytika_pipety_a_spicky_thermo_20c5943161.jpg 146w," sizes="100vw" width="1500" height="1605"><h4>LIMITED OFFER WHILE STOCKS LAST</h4><h5>Everything ages. 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The main mission of the Faculty of Science is to create highly qualified experts in biology, chemistry, geography, geology and in other interdisciplinary fields. Its scientific and research effort aims to solve key problems concerned with the development of human society. Some of the priority long-term subjects are human health, the study of the function and prediction of the development of ecosystems and the biosphere, and the development of environmentally-friendly materials based on the utilization of renewable resources.

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PFAS testing laboratories are being asked to do more than ever before. As regulatory requirements evolve and target analyte lists expand, analysts across environmental, food, and materials testing laboratories must deliver reliable trace-level PFAS measurements in increasingly complex applications. In this seven-part mini webinar series, we explore a range of solutions for trace-level PFAS determination, including Feed Injection and large-volume injection techniques, automated sample preparation, direct injection workflows, SPE strategies, thermal desorption, and complementary LC/MS/MS and GC/MS approaches. Each webinar addresses a different aspect of PFAS analysis, providing practical insights into workflow design, method performance, and laboratory productivity.<h4>Session 4: PFAS Analysis in Soils, Sediments, and Sludges: An EU Regulatory Approach Equivalent to EPA 1633</h4>Environmental laboratories need robust approaches for extracting PFAS from challenging solid matrices while meeting increasingly demanding regulatory requirements. This webinar explores different approaches to PFAS sample preparation for soil, sediment, and sludge, comparing manual extraction with automated SPE and automated solvent extraction using µSPE.In this mini webinar, discover how to:<ul><li>Approach PFAS extraction in challenging solid environmental matrices</li><li>Compare manual and automated sample preparation workflows</li><li>Evaluate manual extraction, automated SPE, and µSPE strategies</li></ul><blockquote>Presenter: Day Powell (Field Application Specialist, Agilent Technologies)Day has worked for Agilent as an Environmental Application Specialist for over a year, before this he worked for United Utilities (UU) as a Technical Specialist responsible for developing new methodologies for both LC/MS and GC/MS applications. Day has worked with PFAS for several years and helped UU to UKAS accredit a novel method for 47 PFAS in drinking water using direct injection to address the latest DWI regulations.</blockquote>

Agilent Technologies: PFAS Mini webinar Series

PFAS Analysis in Soils, Sediments, and Sludges: An EU Regulatory Approach Equivalent to EPA 1633

Explore PFAS sample preparation for soils, sediments, and sludges, comparing manual extraction, automated SPE, and µSPE workflows for robust analysis.

PFAS Analysis in Soils, Sediments, and Sludges

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>Discover a fully automated LC-MS/MS workflow for rapid, sensitive quantitaion of TFA across multiple matrices.Trifluoroacetic acid (TFA) is an ultra-short-chain PFAS of growing concern due to its extreme persistence, high mobility, and widespread occurrence in environmental and drinking water sources. This webinar reviews the emerging regulatory attention and the analytical challenges associated with trace-level measurement, including background contamination, matrix effects, ion suppression, and confirmatory analysis.The webinar introduces a fully automated SCIEX LC-MS/MS workflow for rapid, sensitive quantitaion of TFA across multiplematrices, with the flexibility to incorporate DFA and TFMS into the same analytical approach.Validation data demonstrates excellent linearity, repeatability, accuracy, robustness, and matrix tolerance in drinking water, surface water, wastewater, mineral water, and a wide variety of food matrices. With 40 samples plus standards analyzed in less than four hours, the workflow supports high-throughput routine monitoring for environmental, food, regulatory, and contract testing laboratories.<h5>By attending this webinar you will be able to:</h5><ul><li>Implement strategies to minimize contamination and matrix effects during trifluoroacetic acid (TFA) analysis</li><li>Evaluate the benefits of automated internal standard addition and automated calibration preparation</li><li>Apply a high-throughput LC-MS/MS workflow capable of quantifying TFA down to 20 ng/L with confirmation by two MRM transitions</li><li>Understand how trifluoromethanesulfonic acid (TFMS) and difluoroacetic acid (DFA) can be incorporated into the same analytical workflow</li></ul><h5>Who should attend?</h5>This webinar is designed for laboratory professionals and decision-makers involved in ultra-short-chain PFAS analysis, particularly those working in environmental, drinking water, wastewater, PFAS, regulatory, and contract testing laboratories:<ul><li>Commercial laboratory managers, technical directors, and QA/validation specialists responsible for method implementation, data quality, ROI and regulatory readiness.</li><li>LC-MS/MS method developers, analytical chemists, and application scientists working on trace-level TFA, DFA, TFMS, or broader PFAS workflows.</li><li>Environmental scientists, researchers, and laboratory staff focused on emerging contaminants in drinking water, surface water, wastewater, mineral water, and other complex water matrices such as food.</li></ul><blockquote>Presenter: Carlos Bueno (Senior Aftermarket Workflow Specialist, Food, Environmental and Forensics, SCIEX EMEA)Carlos Bueno is a Senior Aftermarket Workflow Specialist for EMEA at SCIEX with more than 20 years of experience in chromatography and mass spectrometry. After earning his bachelor’s degree in chemistry in 2001 and spending four years at the Madrid Doping Control Laboratory, he built an extensive career focused on analytical application development for food safety and environmental testing markets. Since joining SCIEX in 2023, he has supported laboratories across EMEA in implementing advanced LC-MS/MS solutions and optimizing analytical workflows, and is currently leading SCIEX EMEA's PFAS initiative.</blockquote></div></div></div>

SCIEX: The TFA and DFA challenge solved: ultra-sensitive detection with end-to-end automation

The TFA and DFA challenge solved: ultra-sensitive detection with end-to-end automation

Learn how automated LC-MS/MS enables sensitive TFA, DFA, and TFMS analysis down to 20 ng/L in water and food matrices with high throughput

Automated LC-MS/MS Analysis of TFA and DFA

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>Join our live webinar where industry leaders share cutting-edge solutions, real-world insights, and practical troubleshooting strategies for PFAS analysis.Whether you're facing challenges in sample prep, background signal, or reporting, our experts have guided hundreds of professionals to success—and now it’s your turn.With policies shifting and compliance requirements tightening, staying ahead is essential. Explore the ever-evolving landscape of PFAS regulations around the world as our experts break down the latest global regulatory trends and provide proven lab techniques to help you tackle challenges and adhere to stringent standards.<h5>In this webinar, you’ll gain:</h5><ul><li>A deep dive into PFAS regulations across key regions</li><li>Practical strategies to ensure compliance in your testing workflows</li><li>Lab-proven techniques for detecting and analyzing PFAS effectively</li><li>Insights from industry leaders on navigating future changes</li></ul>Enhance your PFAS knowledge and refine your approach to regulatory adherence today!<h5>Who should attend:</h5><ul><li>Lab technicians, scientists, analytical chemists &nbsp;and lab managers working in environmental and food labs</li></ul><blockquote>Presenter: Dr. Jianru Stahl-Zeng Jianru (Senior Market Development Manager, SCIEX)Dr. Jianru Stahl-Zeng Jianru is Senior Market Development Manager. She has been part of SCIEX since 2001. She initially was part of the application support team and covered not only proteomics, but also small molecules applications. Jianru moved to technical marketing and focused on food and environmental applications. Since 2018 she has been managing the EMEA technical marketing team and projects. Jianru is also the Global Technical Leader for food and environmental applications. On January 2026, she took the role of Senior Market Development Manager, FEF, EMEAI.</blockquote></div></div></div>

SCIEX: PFAS regulations in food and food packaging implemented – proven lab strategies for your PFAS success

PFAS regulations in food and food packaging implemented – proven lab strategies for your PFAS success

Learn proven lab strategies for PFAS testing in food and food packaging. Master global regulations, sample prep, and background noise control.

PFAS Regulations in Food and Food Packaging

<h3>Advancing HPLC Performance with Inert Column Technology</h3>Interactions between analytes and metal surfaces can have an even greater impact on large molecule applications, where sample recovery, peak shape, and quantitative accuracy are critical. Join us to learn how inert column technologies are helping scientists overcome these challenges in the analysis of peptides, proteins, oligonucleotides, and other advanced therapeutics.<h4>Why you should attend</h4>Explore recent innovations in inert column technology and learn how they can address analytical challenges in biopharmaceutical workflows.<h5>Learn more about:</h5><ul><li>The causes and effects of analyte interactions with metal surfaces in HPLC columns and systems</li><li>The analyte types that are susceptible to these interactions, including proteins, peptides, oligonucleotides, and other emerging modalities</li><li>The separation conditions that influence the severity of these interactions</li><li>The benefits of inert HPLC columns and systems for biopharmaceutical characterization and quality control</li></ul><h5>Who should attend</h5>This webinar is designed for scientists and managers involved with HPLC analyses of biopharmaceuticals.Don't miss it!<blockquote>Speaker: Szabolcs Fekete PhD (Consulting Scientist, Genetic Medicine, Waters Corporation)Szabolcs Fekete received his PhD in Analytical Chemistry from the Technical University of Budapest. He worked in analytical R&amp;D in the pharmaceutical industry for 10 years, then joined the University of Geneva in Switzerland as a research associate.He joined Waters Corporation in 2021 and is now a consulting scientist. His current interests include separations of new chemical modalities, fundamentals of chromatography, column technology, and new method development approaches. He has co-authored ~230 publications (including peer reviewed journal articles, book chapters, handbooks, and application notes).</blockquote>

Waters Corporation: The Future of Inert LC Separations

Breaking Barriers: The Rise of Inert Column Technologies for HPLC Biomolecule Separations

Explore inert HPLC column technologies for proteins, peptides, and oligonucleotides, improving recovery, peak shape, accuracy, and method performance.

Advancing HPLC Performance with Inert Column Technology

Metabolomics researchers often face a trade-off between confident, targeted quantification and broad, untargeted discovery, limiting the insight available from a single experiment. Hybrid metabolomics removes the need to choose between these complementary strategies, enabling both robust quantification and comprehensive profiling from the same measurement. The result is a more standardized workflow that conserves valuable sample, time, and resources.In this webinar, explore the principles and scientific potential of an integrated approach to quantification and discovery, and hear how early adopters are applying hybrid metabolomics to aging and cardiometabolic disease research.Attendees will gain practical perspectives on bridging hypothesis-driven and discovery-based science to address a broader range of research questions.<h5>Attend this webinar to:</h5><ul><li>Learn how standardized hybrid metabolomics workflows integrate targeted quantification and untargeted discovery</li><li>Discover how hybrid workflows expand biological insight beyond traditional approaches</li><li>Learn how early adopters apply hybrid metabolomics to aging and cardiometabolic research</li></ul><blockquote>Speaker: Alice Limonciel, PhD (Senior Director, Bruker)Dr. Limonciel holds a PhD in molecular biology from the Medical University of Innsbruck and completed her postdoctoral research at the intersection of multiomics and toxicology, in Austria and the Netherlands. Her work focuses on accelerating the impact of metabolomics and exposomics through strategic initiatives, scientific communication, and community engagement. She developed The STORY principle, a framework to make sense of metabolomics data, and hosts The Metabolomist podcast.Speaker: Brian Hoffmann, PhD (Director of Protein Sciences and Mass Spectrometry Services, The Jackson Laboratory)Dr. Brian Hoffmann is the director of protein sciences and mass spectrometry services at The Jackson Laboratory, where he works with investigators to study lipidomic, metabolic, and proteomic changes in a variety of (patho)-physiological conditions within numerous systems. Additionally, his research focuses on the utilization of multi-modal mass spectrometry technologies to advance a variety of research areas, including research on the aging and Alzheimer’s Disease (AD) brain. Utilizing a combined mass spectrometry imaging lipidomics/proteomics, high-throughput lipidomics/metabolomics, and high-sensitivity proteomics approach the lab has been studying molecular alterations in aging and presymptomatic neurons of wild-type and AD mouse models. Speaker: Michael Witting, PhD (Head of Metalanalytics, Spectroscopy and Chromatography, Labor Becker MVZ eGbR)Dr. Michael Witting is an analytical chemist with more than 15 years of experience in LC-MS based metabolomics and lipidomics. His research interests include the development of novel methods for the analysis of metabolites and lipids from different matrices as well as their annotation and identification using mass spectrometry and orthogonal parameters such as retention times and/or collisional cross sections. Until recently he served as deputy head of the Metabolomics and Proteomics Core and lead scientist for metabolomics at Helmholtz Munich. He also holds a Privatdozent appointment at the Technical University of Munich, where he teaches and supervises students in analytical chemistry and metabolomics. He recently joined Labor Becker MVZ eGbR as head of the unit “Metalanalytics, Spectroscopy and Chromatography” in Munich, bringing his expertise in analytical chemistry, mass spectrometry, and metabolomics into applied analytical and diagnostic settings. Speaker: Markus Langsdorf, PhD (Product Manager, Metabolomics &amp; Lipidomics Biognosys Group)Markus Langsdorf holds a PhD in analytical chemistry from Justus Liebig University Giessen, Germany. He joined biocrates 16 years ago as an LC-MS application specialist, supporting global customers in implementing metabolomics workflows and kit technologies. Today, he leads product management activities and drives product strategy and innovation in metabolomics.</blockquote>

Technology Networks: Hybrid Metabolomics Now Standardized

Hybrid Metabolomics Now Standardized

Learn how hybrid metabolomics integrates targeted quantification and untargeted discovery to support aging, cardiometabolic, and broader biomedical research.

This webinar provides a foundational overview of sample enrichment approaches and LC analysis workflows for oligonucleotides, DNA, and RNA-based therapeutic molecules.We will start by exploring the molecular structure and challenges associated with these molecules and learn about the various chromatographic techniques for their comprehensive characterization.The session will cover the practical approaches for sample preparation and selectivity optimization for gaining higher sensitivity and efficiency in LC-MS/MS methods. Attendees will gain insight into how the method development and optimization approaches can be applied across a variety of DNA and RNA-based molecules for solving the prevalent bioanalytical challenges.<h4>One webinar, two viewing options</h4><h5>Viewing Options</h5>Session 1<ul><li>Tuesday, October 27, 2026 Los Angeles: 10:00 AM PT | New York: 1:00 PM EST Mexico City: 12:00 PM CDT</li></ul>Session 2<ul><li>Wednesday, October 28, 2026 London: 9:00 AM GMT | Berlin: 10:00 AM CET&nbsp; Mumbai: 2:30 PM IST</li></ul><h4>Key Learning Points</h4><ul><li>Describe Nucleic Acids and Oligonucleotides, including their molecular structure, their production process, and how they are delivered as therapeutic medicines.&nbsp;</li><li>Define the ubiquitous challenges associated with these molecules and define the Critical Quality Attributes (CQAs) for mRNA and explain how they relate to product quality, safety, and performance.&nbsp;</li><li>Describe common sample enrichment approaches for these molecules.</li><li>Understand the typical workflow designs and their role in supporting downstream LC and LC-MS/MS analysis. &nbsp;</li></ul><h4>Who Should Attend</h4><ul><li>Any scientists and professionals working in biopharma, life sciences, CROs, CDMOs or analytical laboratories interested in learning about Oligonucleotides and Nucleic Acid based therapeutic analysis workflows as well as sample enrichment and sample preparation approaches. &nbsp;</li></ul><blockquote>Speaker: Namrata Saxena (Technical Manager, Phenomenex)&nbsp;Namrata Saxena is the Technical Manager for the Asia-Pacific region at Phenomenex and is part of the global technical team, she provides expert support for a wide range of chromatographic challenges particularly in the characterization of biotherapeutics and emerging cell and gene therapy modalities. Her role includes delivering technical training, hosting seminars and webinars, and contributing to scientific content development. Prior to joining Phenomenex, Namrata worked as a Product Specialist at Bischoff Chromatography GmbH in Germany where she gained extensive experience in stationary phase chemistry, column manufacturing and method development domains. Namrata is based in Sydney, Australia and can be reached through e-mail or phone.&nbsp;</blockquote>

Phenomenex: Fundamentals First Bio Series: Understanding Oligonucleotides & Nucleic Acid Based Bioanalytical Workflows

Understanding Oligonucleotides & Nucleic Acid Based Bioanalytical Workflows

Learn LC-MS/MS workflows and sample enrichment strategies for oligonucleotides and nucleic acid therapeutics in this Phenomenex technical webinar

Oligonucleotide LC-MS/MS Bioanalysis

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is widely recognized for its high sensitivity, selectivity, and ability to analyze multiple targets simultaneously, making it an increasingly valuable tool for clinical laboratories. However, complex sample preparation and analytical workflows can present challenges for routine implementation and scalability.Join SelectScience® for an expert-led webinar exploring a fully automated LC-MS/MS solution that combines ready-to-use RECIPE reagent kits with the Shimadzu CLAM-2040 automated sample preparation module. Designed to automate the entire workflow from sample preparation through to analysis, this integrated approach has the potential to improve standardization, efficiency, and ease of operation within routine clinical testing environments.Using therapeutic drug monitoring (TDM) as an example, Akihiro Kunisawa, Shimadzu Europa GmbH, will demonstrate a workflow capable of delivering results in less than five minutes per sample. You will also hear from Amanda Bergamin from St. Vincent's Hospital, Australia, as she shares her experience implementing the CLAM-2040 for clozapine testing, meeting growing demand for mass spectrometry-based testing, and improving workflow efficiency through integration with hospital middleware systems.Whether you are looking to expand your laboratory's LC-MS/MS capabilities or explore opportunities for greater automation, this webinar will provide practical insights into the technologies and approaches helping to drive adoption in routine clinical practice.<h5>Certificate of attendance</h5>All attendees who join the live webinar will automatically receive a certificate of attendance, including a summary of key learning outcomes, to support their continuing professional development.If you watch the on-demand recording, you may request a certificate of attendance by emailing editor@selectscience.net.<h5>Webinar Details</h5>• Cost: Free to attend • Location: Online • Duration: 60 minutes • Format: Expert presentation followed by a live Q&amp;A session<h5>Can't attend live?</h5>Register to receive access to the recording after the event, allowing you to catch up on the discussion and revisit key insights at your convenience.<h5>About CLINICAL24</h5>CLINICAL24 is a global initiative dedicated to exploring the challenges facing modern clinical laboratories and highlighting the technologies, expertise, and collaborative approaches helping to improve patient care worldwide.<h4>Who should attend?</h4><ul><li>Clinical laboratory professionals involved in diagnostic testing, including lab managers, medical technologists, and clinical scientists seeking to streamline LC-MS/MS workflows and increase throughput.</li><li>Healthcare and clinical decision-makers including pathologists, clinical chemists, and laboratory directors interested in adopting automated, scalable mass spectrometry solutions.</li></ul><h4>What will this webinar cover?</h4><ul><li>How full automation can transform LC-MS/MS from a specialist technique into a routine testing solution for clinical laboratories.</li><li>How the combination of the Shimadzu CLAM-2040 and ready-to-use RECIPE reagent kits streamlines the entire workflow from sample preparation to result generation.</li><li>Real-world experiences from St. Vincent's Hospital on implementing automated LC-MS/MS workflows for clozapine testing and meeting growing testing demands.</li><li>How integration with laboratory middleware systems can improve workflow efficiency, reduce manual intervention, and support scalable routine operations.</li><li>Practical insights into how automation can accelerate the adoption of LC-MS/MS in routine clinical laboratories while enhancing productivity and standardization.</li></ul><blockquote>Presenter: Amanda Bergamin (Senior Scientist, The Chromatography Department at St. Vincent’s Pathology, Melbourne)Amanda Bergamin is the Senior Scientist in the Chromatography Department at St. Vincent’s Pathology Melbourne. She implemented the organization’s first LCMS diagnostic testing services and is rapidly expanding the range of services offered. With 15 years of experience across multiple industries, she has developed and implemented LCMS assays for high-throughput and routine applications. Her work has ranged from pesticide analysis for the grain export industry to high-throughput screening of hundreds of thousands of drug compounds at the Walter and Eliza Hall Institute of Medical Research (WEHI). She is passionate about delivering high-quality results at breakneck speed while making LCMS technology accessible to all scientists.</blockquote><blockquote>Presenter: &nbsp;Akihiro Kunisawa (Manager of the Clinical MS Solution Center, Clinical MS Solution Center at Shimadzu Europa GmbH)Akihiro Kunisawa is the Manager of the Clinical MS Solution Center at Shimadzu Europa GmbH and has been based in Europe since 2025. He joined Shimadzu Corporation in Japan in 2015 and has approximately 10 years of experience in LC-MS/MS. Throughout his career, he has developed analytical methods using liquid chromatography and mass spectrometry for pharmaceutical analysis, comprehensive metabolite profiling, and clinical applications, while also collaborating extensively with universities and hospitals. His main areas of expertise include metabolomics of small-molecule metabolites, therapeutic drug monitoring (TDM), and newborn screening (NBS). He has developed LC-MS/MS methods for a wide range of clinical applications, including vitamin D metabolites, disease-related biomarkers, and therapeutic drugs. A particular focus of his work is the automation of the entire analytical workflow, including sample preparation. He is currently working on fully automated LC-MS/MS solutions designed to make advanced clinical mass spectrometry simpler and more accessible for routine laboratories.</blockquote><blockquote>Moderator: Lucy Lawrence (Science Editor, SelectScience)Nazim Boutaghou received a Master’s degree in Chemistry and Biology from the University of Bordeaux. Nazim later joined Dr. Richard Coles’ group at Louisiana State University in New Orleans to advance his work in Mass Spectrometry. He is currently the product manager for the Life Sciences at Shimadzu Scientific Instruments.</blockquote></div></div></div>

SelectScience: Simplifying & automating clinical mass spec workflows with real-world case studies

Simplifying & automating clinical mass spec workflows with real-world case studies

Learn how the Shimadzu CLAM-2040 and RECIPE kits automate clinical LC-MS/MS workflows, delivering rapid TDM results in under five minutes per sample

Automated Clinical LC-MS/MS Workflows

Generating high-quality screening and ADME data quickly enough to guide early drug discovery decisions can place significant demands on analytical workflows. Acoustic ejection mass spectrometry (AEMS) offers an alternative approach by combining contactless sample introduction with rapid, label-free mass spectrometric analysis. In this webinar, explore its application to native mass spectrometry screening and microsomal intrinsic clearance assays through two early drug discovery case studies. By attending, you will discover how these workflows enable direct molecular measurements at high throughput and gain practical insight into their performance and analysis times compared with conventional liquid chromatography-mass spectrometry workflows.<h5>Attend this webinar to:</h5><ul><li>Understand how AEMS, using the Echo® MS+ system, supports high-throughput label-free screening</li><li>Hear how AEMS can be used for native mass spectrometry to directly direct non-covalent protein-ligand interactions at throughput suitable for high-throughput screening</li><li>Learn how AEMS has been used for a microsomal intrinsic clearance assay, where dramatically reduced analysis times allow&nbsp;</li><li>faster turnaround of ADME data&nbsp;</li></ul><blockquote>Presenter: Kerri Grove, PhD (Associate Director, Novartis)Kerri Grove earned B.S. degrees in Chemistry and Biochemistry from Bethel University and a Ph.D. in Chemistry from Vanderbilt University. She now works at Novartis in the Global Discovery Chemistry group where her work includes MALDI imaging mass spectrometry for tissue distribution studies, metabolite identification for structural elucidation of drug metabolites, and ADME screening assays.</blockquote>

Technology Networks: Supporting Drug Discovery With Acoustic Ejection Mass Spectrometry

Supporting Drug Discovery With Acoustic Ejection Mass Spectrometry

Learn how SCIEX acoustic ejection mass spectrometry (AEMS) on Echo MS+ speeds drug discovery with high-throughput native MS screening and ADME assays

SCIEX Echo MS+ Acoustic Ejection MS

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div>The investigation of the spatially organized regulation of protein phosphorylation across whole tissue is critical to facilitate an accurate, comprehensive understanding of disease mechanisms and therapeutic effects. Here, we introduce Phos-MASP (micro-scaffold-assisted spatial phosphoproteomics), the first-ever spatial phosphoproteomics method enabling reproducible, in-depth mapping of phosphosites at the whole-tissue level. &nbsp;Uniquely, Phos-MASP also allows parallel profiling of both the proteome and phosphoproteome from the same tissue. &nbsp;Leveraging the robust, reproducible separation of OptiSpray and the ultra-sensitive quantification capabilities of the Orbitrap Astral, this workflow achieves exceptional mapping depth and accuracy. By applying Phos-MASP to an Alzheimer’s Disease model, we reliably mapped ~10,000 proteins and ~30,000 phosphosites, revealing disease-specific intra-brain distributions that offer unprecedented spatial insights into disease mechanisms and therapeutic interventions.<h5>Key learnings:</h5><ul><li>Understanding the fundamentals of Phos-MASP and its significance in spatial phosphoproteomics&nbsp;</li><li>Best practices for implementing Phos-MASP in research&nbsp;</li><li>How Phos-MASP enables parallel profiling of both the proteome and phosphoproteome from the same tissue&nbsp;</li><li>Insights into the robust, reproducible separation of Thermo Scientific OptiSpray ion source and the ultra-sensitive quantification capabilities of the Thermo Scientific Orbitrap Astral MS&nbsp;</li><li>Real-world applications of Phos-MASP in mapping disease-specific intra-brain distributions in Alzheimer's Disease models&nbsp;</li></ul><h5>Who should attend:</h5><ul><li>Researchers and professionals in the fields of proteomics and phosphoproteomics&nbsp;</li><li>Scientists interested in spatially organized regulation of protein phosphorylations&nbsp;</li><li>Individuals looking to expand their knowledge in disease mechanisms and therapeutic effects&nbsp;</li><li>Students and newcomers interested in advanced proteomics techniques&nbsp;</li><li>Anyone interested in staying updated with the latest advancements in spatial phosphoproteomics&nbsp;</li></ul>If you cannot attend the live webinar, please register anyway to automatically receive the link to the recording.<blockquote>Presenter: Jun Qu (Professor, Dept of Pharmaceutical Sciences, University at Buffalo, The State University of New York (SUNY))Jun Qu is a professor in the Department of Pharmaceutical Sciences of SUNY-Buffalo and the director of the Proteomics and Pharmaceutical Analysis Group in the New York Center of Excellence in Bioinformatics and Life Sciences. His research is directed toward the innovations in both global and targeted analysis of proteins, in the context of pharmaceutical and clinical investigations. His group is one of the international leaders in LC-MS-based study of biotherapeutics and drug targets in pre-clinical models, as well as MS1-based, large-cohort quantitative proteomics. He has &gt;160 peer reviewed publications and &gt;80 grants funded as PI or co-I.</blockquote></div></div></div>

Thermo Fisher Scientific: Whole-tissue, parallel mapping of 10,000 proteins and 30,000 phosphosites by integrating MASP with OptiSpray/Orbitrap Astral

Whole-tissue, parallel mapping of 10,000 proteins and 30,000 phosphosites by integrating MASP with OptiSpray/Orbitrap Astral

Jun Qu showcases workflow for spatial proteomics using Thermo Scientific OptiSpray ion source, cartridge column and the Thermo Scientific Orbitrap Astral MS.

mapping of 10,000 proteins with OptiSpray/Orbitrap Astral

On October 27, Abbie Breton, Applications Development Manager, will present the next edition of Tosoh Tuesday, a webinar series held by Chromatography Experts. &nbsp;Tianyu Li, Applications Scientist - GPC/SEC Instruments at Tosoh Bioscience, will present the next edition of Tosoh Tuesday, a webinar series held by Chromatography Experts.&nbsp;This webinar will introduce a novel multi-angle light scattering (MALS) approach that uses a 505 nm green laser independently of the refractive index (RI) detector wavelength, enabling significantly greater light scattering sensitivity than conventional red-laser systems. By using a shorter-wavelength green laser, this new approach generates approximately three times greater scattering intensity, improving the characterization of challenging samples and supporting more efficient method development. To validate the methodology, molecular weight measurements obtained using green-laser MALS were compared with results from universal calibration with online viscometry.&nbsp;Attendees will learn how independent-wavelength MALS combines enhanced sensitivity with accurate molecular weight and size characterization, expanding analytical capabilities for both polymer and biomolecular applications.After the webinar, ask your questions during the live Q and A session.&nbsp;<blockquote>Presenter: Abbie Breton (Applications Development Manager, Tosoh Bioscience)Presenter: Tianyu Li (Applications Scientist - GPC/SEC Instruments at Tosoh Bioscience)</blockquote>

Tosoh Bioscience: Tosoh Tuesday - Breaking Wavelength Constraints: More Sensitive and Versatile MALS Analysis

Tosoh Tuesday - Breaking Wavelength Constraints: More Sensitive and Versatile MALS Analysis

how independent-wavelength green-laser MALS enhances sensitivity for GPC/SEC analysis and supports accurate molecular weight and size characterization.