What do chromatography, gemstones, rainbows and even cats have in common? At KNAUER’s latest Girls’ Day in Berlin, 15 schoolgirls explored exactly that question. Through a series of hands-on activities, they discovered how HPLC instruments are developed and manufactured, learned the basics of spectroscopy and chromatography, and met women working across science, engineering, product management and company leadership.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_1_A_student_observes_the_rainbow_spectrum_of_white_light_8ef24d9700.jpeg" alt="KNAUER: Figure 1 A student observes the rainbow spectrum of white light." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_1_A_student_observes_the_rainbow_spectrum_of_white_light_8ef24d9700.jpeg 228w," sizes="100vw" width="624" height="427"><h4>A Day to Explore STEM Careers</h4>Girls’ Future Day, widely known as Girls’ Day, gives schoolgirls across Germany an opportunity to experience professions in which women are still underrepresented. Instead of learning about careers only in the classroom, participants can spend a day inside companies, laboratories and technical workplaces and see what these jobs actually involve.KNAUER has participated in Girls’ Day for 17 years, and demand for places has become consistently high. The attraction is easy to understand: visitors do not simply listen to presentations. They can experiment, assemble components, talk directly with employees and discover how science and engineering are applied in everyday work.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_2_Hands_on_experience_and_wonder_at_Girls_Day_2025_98da525b3a.jpg" alt="KNAUER: Figure 2 - Hands-on experience and wonder at Girls’ Day 2025: 13 interested girls assembled pump heads, learned what HPLC is, and how such equipment is developed" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_2_Hands_on_experience_and_wonder_at_Girls_Day_2025_98da525b3a.jpg 125w," sizes="100vw" width="1024" height="1280"><blockquote>“That moment when the girls realize, with sparkling eyes, just how cool science can be—that’s exactly why I love Girls’ Day. It’s worth every bit of the effort!” – Dr. Kristin Folmert, chemist and product manager at KNAUER</blockquote><h4>From Laboratory Instruments to a Wide Range of Careers</h4>At KNAUER wissenschaftliche Geräte GmbH, laboratory instrumentation is designed, developed, manufactured, tested and marketed from Berlin for customers around the world.That requires far more than chemists alone. The company brings together people working in mechanical production, logistics, media design, mechatronics, software development, science, product management and company management.For the participating girls, this offered a chance to meet women following very different career paths and to see that a technology company can provide opportunities across many disciplines.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_3_The_girls_learned_what_chromatography_and_HPLC_are_a7db4e8eb3.jpg" alt="KNAUER: Figure 3 - The girls learned what chromatography and HPLC are, what they are used for, and how a UV/Vis detector works. They then built their own handheld spectroscope and experimented with white light and various color filters." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_3_The_girls_learned_what_chromatography_and_HPLC_are_a7db4e8eb3.jpg 245w," sizes="100vw" width="1024" height="609"><h4>Women in Science and Technology at KNAUER</h4>Women account for 37% of KNAUER’s workforce, with particularly strong representation in scientific and management positions. The company reports a gender pay gap of 1.84% for 2026, compared with an unadjusted German gender pay gap of 16% in 2025. Women also hold 44% of leadership positions at KNAUER, including several positions performed on a part-time basis.The company emphasizes practical measures intended to make technical careers accessible to a wider range of employees. These include flexible work models, support for childcare and technical solutions such as indoor cranes for handling heavy components.During Girls’ Day, these policies become less abstract. Participants meet scientists, engineers and managers who can describe how they entered their professions and how their careers developed.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_4_During_a_visit_to_the_equipment_development_department_scientist_Thy_Vu_talks_about_her_career_at_KNAUER_3bd9af2786.jpg" alt="KNAUER: Figure 4 - During a visit to the equipment development department, scientist Thy Vu talks about her career at KNAUER. She wrote her bachelor’s thesis here and then worked as a student assistant in development during her master’s program. Subsequent to completing her master’s degree, she accepted a permanent position at KNAUER in the development department. Today, she is developing the pump drive of the future and tells the fascinated girls which gemstones are used in such a pump (sapphires and rubies)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_4_During_a_visit_to_the_equipment_development_department_scientist_Thy_Vu_talks_about_her_career_at_KNAUER_3bd9af2786.jpg 245w," sizes="100vw" width="1024" height="614"><h4>Role Models and First-Hand Career Insights</h4>Several KNAUER employees are also involved in <a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/groups/13080121/">International Women in Chromatography</a>, a network supporting women and non-binary professionals working in chromatography.Throughout the day, the students encountered women at different stages of their careers: from university students and young scientists to experienced product managers, developers and Managing Director Alexandra Knauer.The message was not simply that STEM careers are available to women, but that scientific and technical work can take many forms. Networking, curiosity, willingness to ask questions and confidence in one’s own abilities were recurring themes throughout the event.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_5_A_girl_works_intently_and_with_great_care_on_her_spectroscope_ed94a2a049.jpg" alt="KNAUER: Figure 5 - A girl works intently and with great care on her spectroscope. None of the girls glance at their phones; they are all polite, and many feel comfortable asking questions openly. We are very excited about this generation of bright young talents." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_5_A_girl_works_intently_and_with_great_care_on_her_spectroscope_ed94a2a049.jpg 127w," sizes="100vw" width="405" height="496"><h4>Learning HPLC by Doing</h4>The scientific part of the day began with the basic principles of high-performance liquid chromatography (HPLC).To make separation easier to understand, the group first experimented with light and heavy balls inside a large glass column. From there, the discussion moved to the individual components of an HPLC system.One analogy compared an HPLC instrument with the human body: the pump moves liquid much like the heart circulates blood, separation takes place in the column, and the detector observes the separated compounds through their interaction with light.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_6_The_HPLC_and_its_various_modules_depicted_as_human_organs_855ab67aac.jpg" alt="KNAUER: Figure 6 - The HPLC and its various modules, depicted as human organs." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_6_The_HPLC_and_its_various_modules_depicted_as_human_organs_855ab67aac.jpg 245w," sizes="100vw" width="1210" height="670"><h4>Building a Spectroscope and Seeing Light Differently</h4>Each participant then constructed a small handheld spectroscope.The task required both careful reading and manual dexterity, particularly when fitting the delicate lens. Working together, the girls quickly developed better ways to complete the assembly—a small example of how real development projects evolve through cooperation and continuous improvement.Once finished, the spectroscopes revealed the spectrum of white light as a rainbow together with visible spectral features. Colored filters placed between the light source and the spectroscope then demonstrated how absorption changes the observed spectrum.This connected the practical activity with concepts introduced earlier in the day: visible light, wavelength, absorption and how optical signals eventually become peaks in HPLC detection.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_7_A_11_year_old_girl_gazes_fascinated_at_her_rainbow_4f713de2ae.jpg" alt="KNAUER: Figure 7 - A 11-year-old girl gazes fascinated at her rainbow and notices that while all the colors are visible, some areas are brighter while others are quite dark. “Is the spotlight not pure white, or is my spectroscope absorbing light?” Such clever questions arise when girls are encouraged to explore things for themselves." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_7_A_11_year_old_girl_gazes_fascinated_at_her_rainbow_4f713de2ae.jpg 200w," sizes="100vw" width="1024" height="800"><h4>Inside Instrument Development and Manufacturing</h4>The program then moved from theory into KNAUER’s production environment.In the mechanical manufacturing area, participants saw CNC machines and robotic systems producing precision components for laboratory instruments. They could watch parts of an HPLC pump head taking shape directly from metal components and learn why accurate machining is essential for reliable instrument performance.<blockquote>“This is like science fiction!” – Mariko Stahr, Girls’ Day participant</blockquote>In the development department, engineer Thy Vu demonstrated her work on pump-drive technology and explained how developers investigate parameters such as motor torque. The girls were also able to handle some of the materials used inside an HPLC pump.One detail generated particular interest: components made from sapphire and ruby. This opened a discussion about material properties, crystal structures and why instrument developers benefit from understanding chemistry as well as engineering.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_8_Thomas_Mueller_explains_to_the_girls_how_CNC_machines_mill_the_housing_for_a_pump_head_bd714b9b50.jpg" alt="KNAUER: Figure 8 - Thomas Müller explains to the girls how CNC machines mill the housing for a pump head from a block of metal and why precision is crucial in this process. On the left is one of the robotic arms that continues working even at night, allowing employees to focus solely on daytime work and more demanding tasks. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_8_Thomas_Mueller_explains_to_the_girls_how_CNC_machines_mill_the_housing_for_a_pump_head_bd714b9b50.jpg 245w," sizes="100vw" width="1278" height="468"><h4>Assembling a Real HPLC Pump Head</h4>The final practical station brought the participants into instrument assembly.Each girl was given the opportunity to assemble a pump head herself. The work proved more demanding than it initially appeared, requiring both hands to coordinate several components accurately.With guidance from KNAUER training supervisor Ronald Berger, the participants completed their assemblies before each pump head underwent a final technical check to verify that the pistons moved correctly.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_9_A_girl_is_screwing_the_check_valve_with_the_check_valve_holder_i_cf84fb4375.jpg" alt="KNAUER: Figure 9 - A girl is screwing the check valve with the check valve holder into the pump head. Everything is then tightened using a torque wrench." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_9_A_girl_is_screwing_the_check_valve_with_the_check_valve_holder_i_cf84fb4375.jpg 179w," sizes="100vw" width="376" height="327">The day concluded with lunch and another opportunity to speak with Managing Director Alexandra Knauer, who has long supported initiatives intended to improve the visibility of women and encourage young people to consider STEM careers.Participants received certificates and “I love HPLC” bags with small gifts before leaving KNAUER with their own impressions of what a future in science and technology could look like.<h4>So Where Do the Cats and Rainbows Come In?</h4>The rainbow seen through a spectroscope provides a simple demonstration of the same basic optical principle used in many analytical measurements.When white light is dispersed, its different wavelengths become visible as a spectrum. If part of that light is absorbed by an object or substance, the resulting spectrum changes. Measuring which wavelengths are absorbed can therefore reveal information about the material interacting with the light.The article illustrates the idea with a deliberately simple example: a cat sitting in front of a light source may absorb most of the light, but its silhouette still provides information about what is blocking the beam.Similarly, analytical detectors can obtain information about molecules by measuring how they interact with light.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_10_The_cat_actually_absorbs_all_the_light_af8452f58d.jpg" alt="KNAUER: Figure 10 - The cat actually absorbs all the light, but its outline still lets us know that there’s a fluffy cat sitting there. In HPLC, a[SD5.1] molecule’s light absorption also tells us a great deal about its identity. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_10_The_cat_actually_absorbs_all_the_light_af8452f58d.jpg 236w," sizes="100vw" width="1024" height="676">The same principle also helps explain the colors of evening sunlight. When sunlight travels through a longer path in the atmosphere, shorter-wavelength blue light is scattered more strongly, leaving proportionally more of the longer-wavelength red and orange light reaching the observer.For the students at KNAUER, concepts such as these transformed HPLC and spectroscopy from abstract scientific terminology into something they could build, observe and discuss themselves.And that is ultimately the purpose of Girls’ Day: to show young people that science and technology are not distant subjects confined to textbooks, but fields full of practical questions, creative problem solving and possible future careers.

Girls Just Wanna Have Fun With KNAUER – A Girls' Day Full of Rainbows

Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 21st September 2026? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you application notes by KNAUER and Shimadzu, technical note by Thermo Fisher Scientific and poster by Waters Corporation / SOFT!<h3>1. KNAUER: Precise Catechin Profiling in Various Types of Tea</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/VFD_0198_knauer_precise_catechin_profiling_in_various_types_of_tea_d607cde5ba.pdf">Full PDF for download</a></li></ul>Fresh tea leaves contain high concentrations of catechins, which have many beneficial properties. These include antioxidant, anti-inflammatory as well as antimicrobial effects, and it is even claimed that they have the potential to prevent cancer [1]. In addition, the taste and mouthfeel of a tea strongly depend on its catechin profile. The catechin content of tea leaves varies based on cultivation area, age and variety, as well as on how they are fermented, processed and packed. Therefore, the catechin content is an important marker for the quality of tea.&nbsp;The analysis of catechins can be challenging. The structural similarity of the catechin isomers and other closely related compounds result in similar behavior and a difficult separation (Fig. 1). Catechins possess many phenolic hydroxyl groups, which are prone to secondary interactions, like hydrogen bonding. Classical as well as highly endcapped C18 columns offer only limited retention and selectivity for catechins. Therefore, the KNAUER column portfolio has been expanded to include a pentafluorophenyl (PFP)-modified stationary phase (Eurospher II 100-3 PFP column 50 x 2 mm). It offers optimal separation of the catechins based on hydrophilic, hydrophobic and π-π-interactions. The column withstands acidic eluents (pH 1.5–10) as well as 100 % aqueous conditions, which are beneficial for the retention of hydrophilic compounds. The KNAUER Gradient Prediction Tool assisted with the challenging method development which is described in detail in the TechNote “The Gradient Prediction Tool: Method Development for the Separation of Catechins from Tea”. Here, the application of the optimized method for the identification and quantification of catechins in tea extracts is shown. The seven compounds specified in ISO-14502-2 (2005), as well as two additional catechins known as (+)-gallocatechin and (–)-gallocatechin gallate, were quantified.<h4>MATERIAL AND METHODS</h4><ul><li>Pump: <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2374">P8.1L</a>; high pressure gradient&nbsp;</li><li>Liquid Handler: <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1454">LH 8.1L </a>With FastWash station, and Robotic cooler. Loop: 20 µl.</li><li>Thermostat: <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2376">CT 2.1L&nbsp;</a></li><li>Detector: <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2424">DAD 6.1L&nbsp;</a></li><li>Flow cell: Analytical LightGuide flow cell (50 mm, 6 µl)&nbsp;</li><li>Software: ClarityChrom 10.1</li></ul><h4>CONCLUSION&nbsp;</h4>The application note demonstrates the reliable separation and quantification of catechins and caffeine in tea extracts using the new KNAUER PFP column. Using an optimised gradient predicted with the KNAUER Gradient Prediction Tool, nine tea-related compounds were separated in under 23 minutes. The tested tea samples showed different catechin content highlighting how strongly tea composition depends on the product type and processing.<h3>2. Shimadzu: New Derivatization Method for Quantitative Analysis of Δ⁹-THC-COOH in Urine</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_01_01215_en_c98174629b.pdf">Full PDF for download</a></li></ul><h5>User Benefits</h5><ul><li>The risk of limited availability of stable isotope-labeled standards can be avoided by synthesizing internal standards through derivatization.&nbsp;</li><li>The derivatizing agent IPPAH and its corresponding stable isotope IPPAH-d6 can be synthesized easily and inexpensively from acetone (or acetone-d6).&nbsp;</li><li>This approach achieves sufficient sensitivity and quantitative accuracy for the determination of Δ⁹-THC-COOH in urine.</li></ul>In Japan, the Cannabis Control Act and the Narcotics and Psychotropics Control Act were amended in December 2024. While cannabis was legalized for industrial and medical uses, stricter cannabis regulations have been enacted to prevent harm from its abuse. The primary psychoactive cannabinoid, delta-9-tetrahydrocannabinol (Δ⁹-THC), is extensively metabolized in the body and is excreted mainly in urine and feces as 11-nor-9-carboxy-THC (Δ⁹-THC-COOH) and its glucuronide conjugates. Consequently, Δ⁹-THC-COOH must be analyzed to confirm cannabis use. For LC-MS/MS quantitation, the stable isotope-labeled internal standard Δ⁹-THC-COOH-d3 is commonly used to correct for matrix effects. However, most suppliers of stable isotope standards are located in the U.S., making these standards difficult to obtain due to import procedures. Furthermore, there may be additional importrelated supply risks for stable isotope standards in the future.&nbsp;This Application News describes a technique for quantitating Δ⁹-THC-COOH using an internal standard that is synthesized easily and inexpensively by derivatization with IPPAH (1- isopropylpiperidine carboxylic acid hydrazide), which characteristically reacts with carboxyl groups, and its corresponding stable isotope IPPAH-d6.<h4>Analysis Conditions&nbsp;</h4>LC-MS/MS analysis conditions are shown in Table 1. The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=1&amp;search=Nexera+XR">Nexera XR</a> and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=1&amp;search=LCMS-8050">LCMS-8050 systems</a> were used.<h4>Conclusion&nbsp;</h4>Derivatization with IPPAH and its stable isotope analog, IPPAHd6, enabled the simple and inexpensive preparation of an internal standard. This approach provides sufficient sensitivity and accuracy for the determination of Δ⁹-THC-COOH in urine. Most stable isotope-labeled standards are supplied by foreign manufacturers, creating a risk of delays or difficulties in procurement due to import/export regulations. By synthesizing the internal standard through derivatization, this risk can be minimized.<h3>3. Thermo Fisher Scientific: High-throughput quantitative proteomics with Evosep Eno and the Orbitrap Astral Zoom Mass Spectrometer</h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/tn_004544_ov_astralzoom_evosepeno_htp_proteomics_tn004544_na_en_f31db9084e.pdf">Full PDF for download</a></li></ul>High-throughput proteomics is a critical enabling technology for large clinical studies, high-content drug screening, and systems biology research, allowing for comprehensive and quantitative analysis of complex proteomes across large sample cohorts within practical timeframes. As biological and translational studies expand in scale and complexity, the ability to generate deep and reproducible proteome measurements across thousands of samples has become increasingly essential for robust biomarker discovery, network-level systems modeling, and downstream analyses. In these contexts, accurate and precise protein quantitation must be maintained without sacrificing throughput, placing stringent demands on the performance and robustness of both LC instruments and mass spectrometers.&nbsp;To meet these increasing analytical demands, the Evosep Eno was developed as a high‑throughput LC system that combines robustness, ease of use, and highly reproducible chromatography. It offers six standardized methods: 30, 60, 100, 200, 300, and 500 samples per day (SPD), allowing users to select the throughput that aligns best with their study goals.1 These predefined methods ensure consistent gradient delivery, highly stable retention times, and reproducible system performance across instruments and laboratories.2 By reducing LC‑related variability and simplifying everyday operation, the Evosep Eno offers a strong and consistent foundation for large‑scale proteomics workflows, particularly those relying on short gradients and high reproducibility required for downstream quantitative analysis.<h4>Experiment</h4><h5>Instrumentation&nbsp;</h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=291&amp;search=evosep+eno">Evosep Eno&nbsp;</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1959">Orbitrap Astral Zoom Mass Spectrometer&nbsp;</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2464">Thermo Scientific™ EASY-Spray™ Ion Source&nbsp;</a></li><li>Evosep™ Pod for EASY-Spray Ion Source</li></ul><h5>Software&nbsp;</h5><ul><li>Biognosys Spectronaut® 19.7 software&nbsp;</li><li>MacCoss Lab Software Skyline-Daily V25.1</li></ul><h4>Summary&nbsp;</h4><h5>Seamless and easy integration for high-throughput proteomics&nbsp;</h5>Evosep Eno integrates seamlessly with the Orbitrap Astral Zoom Mass Spectrometer, supported by EASY-Spray source-compatible columns, emitters, and the Evosep Pod column oven for a simple, streamlined, high-throughput workflow.&nbsp;<h5>Deep proteome coverage at 500 SPD&nbsp;</h5>Optimized MS parameters for the standard 500 SPD Evosep Eno gradient enabled identification of more than 6,500 protein groups and 71,000 modified peptides from three replicates of 200 ng Pierce HeLa Digest/PRTC Standard.<h5>Reproducible quantitation across standard gradients&nbsp;</h5>Across all standard Evosep Eno gradients, the workflow delivered highly reproducible label-free quantification, with median protein group %CVs at or below 5.2%, while identifying more than 10,500 protein groups and 190,000 modified peptides from five replicates of 200 ng Pierce HeLa Digest/PRTC Standard at 30 SPD.&nbsp;<h5>Robust chromatography at ultra-high throughput&nbsp;</h5>Chromatographic performance remained stable and robust at 500 SPD, with nearly 100 consecutive runs showing PRTC retention time standard deviations below 0.4 seconds and a median of 6 DPPP.&nbsp;<h5>Strong linearity for confident quantitation&nbsp;</h5>Quantitative performance remained strong at 500 SPD, with PRTC peptides showing excellent linearity across the active gradient (R² &gt;0.98) when spiked from attomolar to femtomolar concentrations.<h3>4. Waters Corporation / SOFT: COMPARATIVE EVALUATION OF HIGH RESOLUTION MASS SPECTROMETRY ACQUISITION STRATEGIES FOR THE DETECTION AND ANALYSIS OF ILLICIT DRUG SUBSTANCES</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/720009592_0bd2b5ee6a.pdf">Full PDF for download</a></li></ul><div><div><section><div><div><div><div><div><div>The poster compares two high-resolution time-of-flight mass spectrometry acquisition strategies for toxicology screening: targeted Tof-MRM and data-independent Tof-MSE, both implemented on a Waters <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1148">Xevo MRT MS</a> coupled to an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/199">ACQUITY UPLC I-Class FTN PLUS System</a>. The aim was to determine whether these approaches could meet routine service requirements for drug testing while also broadening the number of substances that can be detected beyond conventional targeted panels. Urine samples were prepared across a wide concentration range for 20 target analytes, and the methods were also applied to 20 anonymized authentic urine samples.Both workflows used a 15-minute LC separation on an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1952">ACQUITY HSS C18 column</a> under positive electrospray ionization. In the targeted Tof-MRM mode, selected precursor ions were isolated and fragmented, with quantifier and qualifier ions monitored for sensitive quantitative analysis. In contrast, Tof-MSE operated in a data-independent mode, alternating between low and elevated collision energies to collect accurate-mass precursor and fragment-ion information for a broad range of compounds. Data were processed in the waters_connect platform using MS Quan for Tof-MRM and UNIFI with the Waters Toxicology Library, containing more than 2,100 drugs and metabolites, for Tof-MSE.The targeted Tof-MRM method provided the highest sensitivity, with limits of detection ranging from 0.05 to 0.5 ng/mL in fortified urine. The broader Tof-MSE workflow achieved LODs of approximately 0.5 to 5 ng/mL. When both strategies were applied to authentic urine samples, they showed excellent qualitative agreement. Importantly, Tof-MSE detected additional compounds outside the predefined target panel, including commonly encountered medications, benzodiazepines, antidepressants, and illicit drug substances that would not have been captured by the targeted method alone.Overall, the study shows that Tof-MRM can deliver sensitivity comparable to conventional tandem-quadrupole LC-MS/MS for targeted urinary drug analysis, while Tof-MSE adds broader sample characterization and retrospective screening capability. Used together, the two acquisition strategies provide a flexible approach that combines sensitive quantification of predefined analytes with expanded screening for unexpected or previously untargeted drug substances in complex biological samples.</div></div></div></div></div></div></section></div></div>

News from LabRulezLCMS Library - Week 39, 2026

Proper care and maintenance of HPLC columns are essential for getting accurate results and saving on replacement costs. Extending the HPLC column life not only ensures consistent performance but also reduces downtime and the need for frequent replacements.Routine maintenance is equally essential for sustaining column functionality. Correct handling of the column is paramount, ensuring strict compliance with the manufacturer’s specifications regarding pressure, pH, flow rate, and temperature.In the next section, we will explore these best practices in greater detail, offering further guidance on essential HPLC column maintenance strategies. Whether you’re working in a high-throughput lab, or conducting occasional analyses, these strategies will help you get the most out of your <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products?category=48&amp;manufacturerItems=50">HPLC columns</a>.<h3>Essential Guidelines for Extending HPLC Column Life</h3>By adopting these simple yet effective practices, you can greatly extend the HPLC column life while ensuring reliable, high-quality results in your analyses.<h4>Proper Column Handling</h4>HPLC columns should be handled with care to prevent physical damage or shock. The pump should not be started at high flow rates; instead, the flow rate should be gradually increased over several minutes. A pump pressure limit should be set to protect the column from over pressuring, as sudden pressure changes can lead to voids, negatively affecting the column’s performance.<h4>HPLC Column Conditioning and Equilibration</h4>Conditioning is a critical step for preparing a new or stored HPLC column by replacing the storage solvent with the desired mobile phase. Care must be taken to avoid introducing immiscible solvent mixtures into the column. Universally miscible solvents such as THF (tetrahydrofuran) or IPA (isopropyl alcohol) can be useful for this process when moving from normal phase to reversed phase solvent systems. Care must also be taken to ensure that solvents that may be damaging to a specific stationary phase are avoided.For example, if a reversed-phase column experiences phase collapse due to 100% aqueous mobile phases, it should be reactivated. This process involves running 100% acetonitrile at a high flow rate and a temperature as high as 60°C. It is essential to ensure no solid buffers precipitate from residual solvents. Depending on the column condition, between 50 and 100 column volumes are needed for complete reactivation and equilibration, restoring the column’s efficiency for future use.<h4>Optimizing Operating Conditions</h4>Optimizing operating conditions is paramount to enhancing HPLC column efficiency and prolonging their operational lifespan. A fundamental aspect of this is strict adherence to the manufacturer’s recommended temperature, pH and pressure parameters.Deviating from these limits, particularly by operating at elevated temperatures, can significantly hasten the degradation of the stationary phase and hardware, thereby compromising overall performance. Elevated temperatures can also narrow the pH operating range, exacerbating the risk of column degradation through phenomena such as peak broadening or diminished efficiency.Effective pressure management is equally crucial. Sudden pressure surges or mechanical shocks can result in bed voiding, leading to poor chromatographic performance, such as split peaks and reduced separation efficiency. Gradual ramping of flow and pressure, implemented each time the column is initiated, mitigates these risks. Many modern HPLC systems are equipped with automated flow-pressure ramping capabilities, ensuring smoother transitions and reducing the potential for column damage.In addition, vigilant monitoring of the mobile phase's pH is vital to the maintenance of HPLC column integrity. Deviations from the optimal pH range can cause significant harm to the stationary phase. For instance, leads to ligand hydrolysis which leads to a loss of stationary phase functionality and diminished column performance over time. High pH can lead to silica degradation. This weakens the silica structure, causing particle dissolution, void formation, and loss of column efficiency. Maintaining the pH within optimal boundaries is essential for preserving the column’s structural integrity and ensuring consistent chromatographic performance.Furthermore, incorporating inline filters and guard columns into the system serves as a proactive measure to prevent particulates and harsh sample matrices from damaging the analytical column. These preventive tools significantly enhance operational conditions and safeguard the column from contamination, ultimately contributing to extended HPLC column lifetime and reliable performance.<h4>Regular Column Maintenance</h4>Effective routine maintenance is paramount to extending the HPLC column lifetime and ensuring the consistent performance of HPLC columns. A critical aspect of this maintenance is the thorough washing of the column after each use to eliminate residual sample components and mobile phase contaminants.The cleaning process generally involves performing an isocratic or gradient wash using a solvent system similar to the one previously used on the column but substituting the buffer with HPLC-grade water. This helps effectively remove any residual buffer components from the column. This meticulous cleaning process is vital to preventing the accumulation of impurities that could compromise the stationary phase and lead to decreased efficiency over time.Post-cleaning, it is imperative to end-cap the column before storage to prevent the stationary phase from drying out, a condition that can negatively impact the column’s future performance. Proper capping or sealing ensures that the column remains in optimal condition, safeguarding its structural integrity and readiness for subsequent analyses.Additionally, utilizing an older HPLC system as a dedicated wash station can further streamline maintenance practices, freeing up live systems for active use. Consistently adhering to a rigorous cleaning and storage regimen not only enhances the longevity of HPLC columns but also guarantees the delivery of precise and reliable analytical results.For severe contamination or pressure buildup, backflushing may be necessary to dislodge tightly bound contaminants. However, backflushing should only be performed when absolutely necessary, as it can stress the column packing material. It is essential to consult the manufacturer’s instructions before attempting this method.

How to Extend the Lifetime of HPLC Columns?

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Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

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In this webinar, our expert speakers will provide an overview of the fundamentals of light scattering for macromolecular characterization by size exclusion chromatography (SEC), including good practice for sample preparation and experimental methods.
The use of multi-angle light scattering (MALS) as a tool to determine effective SEC conditions for the macromolecule of interest will be discussed. A description of the measurable quantities SEC-MALS offers and the careful considerations that are required in fitting light scattering data to ensure accurate macromolecular molecular weight and size measurements will be provided.
Key learning objectives
<ul>
<li>Explore the fundamentals of light scattering and absolute molecular weight detection for macromolecules</li>
<li>Learn about sample preparation, instrumentation setup, dn/dc requirements, and good practices</li>
<li>Understand what is needed for fitting light scattering data to ensure quality data for molecular weight and size</li>
<li>Explore SEC-MALS applications</li>
</ul>
Who should attend?
<ul>
<li>Principal investigators</li>
<li>Laboratory technicians/technologists</li>
<li>Synthetic polymer scientists</li>
<li>Biopolymer scientists</li>
<li>Analytical scientists</li>
</ul>
<h4>View other webinars in this series here:</h4>
Part 1: <a href="https://lcms.labrulez.com/webinar/3690">Unraveling the Intricacies of Size Exclusion Chromatography – Strength and Limitations</a>
Part 2: <a href="https://lcms.labrulez.com/webinar/3691">Detection in Gel Permeation Chromatography /Size Exclusion Chromatography</a>
Part 4: <a href="https://lcms.labrulez.com/webinar/3693">Concepts, Challenges and Applications for 2D-LC of Polymers</a>
Certificate of attendance
All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.
<blockquote>
Presenter: Dr. Paul Balding (Associate Research Scientist, Dow Inc.)
</blockquote>
<blockquote>
Dr. Paul Balding received his PhD in Chemistry from The Georgia Institute of Technology for work on the synthesis and characterization of model polyelectrolytes and dynamics behavior in low salt solutions. He received a BSc Honours in Chemistry from the University of Wollongong, Australia, working on the rheology and mechanical performance of 3D-printed hydrogel materials. He is currently a subject matter expert working in the separations science team at Dow Chemical in the polyolefin space with a focus on high-temperature SEC-coupled MALS.
</blockquote>
<blockquote>
Presenter: Dr. Daniela Held (R&amp;D Director, GPC/SEC Center of Excellence, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Dr. Daniela Held received her PhD in Chemistry from the University of Mainz, Germany, for work on the synthesis and characterization of star-branched polyelectolytes. In 2000, she joined the software team of PSS Polymer Standards Service GmbH, developing workflow solutions for advanced detection techniques and developing customer trainings. Through the acquisition of PSS by Agilent Technologies, she became R&amp;D director at the GPC/SEC Center of Excellence in Mainz, Germany.
</blockquote>
<blockquote>
Presenter: Jemima Arnold (Editorial Assistant, SelectScience)
</blockquote>
<blockquote>
Jemima studied Cellular and Molecular Medicine at the University of Bristol, UK, and as a member of the Editorial team, she now plays an integral role in shaping the content on SelectScience.
</blockquote>

SelectScience: Characterization of Macromolecules by SEC-Light Scattering

Characterization of Macromolecules by SEC-Light Scattering

An overview of the fundamentals of light scattering for macromolecular characterization by size exclusion chromatography (SEC).

Oligonucleotide analysis has gained considerable interest over the last few years with the successful introduction of mRNA vaccines and the synthetic short interfering RNA therapeutics.
Synthetic RNA drug products extend the need for new analytics to accurately determine impurities generated during manufacture. The highly charged, linear chain structure already provides analytical challenges. The introduction of sulphur onto an asymmetric phosphate group for stability causes additional chromatography related problems. Amine ion pair and metal adducts create a quantitation problem due to multiple split signals. In-source generated impurities compound this problem.
This webinar will present a successful routine method with optimized HRMS conditions developed for synthetic oligonucleotide impurity analysis which resolves all of these problems. We hope to see you there! 
Learning Points: 
<ul>
<li>Routine method for synthetic oligonucleotide impurity analysis</li>
<li>How to resolve analytical challenges for ASO RNA analysis</li>
</ul>
Who should attend?
<ul>
<li>Biopharmaceutical Research Scientists </li>
<li>Analytical Scientists from Biopharma companies working on or interested in oligonucleotide-based therapies</li>
<li>PhD students and scientists looking to advance knowledge of oligonucleotide analysis</li>
</ul>
Short notice:
Can&#39;t attend the live broadcast? No problem! Register anyway and you will automatically receive the link to the webinar recording. 
<blockquote>
Presenter: Dr. Ken Cook (European Manager BioPharma Expert Support Group, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Moved to industry from a University lectureship in Biochemistry, University of Newcastle upon Tyne, following 7 years’ experience in academia. Now with over 35 years’ experience with Thermo Fisher Scientific using a wide range of analytical equipment and software. Publications range from metabolomics, proteomics to large biopharmaceutical drug analysis. Current job title is the European manager for the BioPharma expert support group. This involves the support of Bio-Pharmaceutical applications to characterise protein and oligonucleotide based bio-therapeutics. This involves ongoing collaborations with the Biopharmaceutical industry and academia. Characterization methods of Bio-therapeutics include, monoclonal antibodies, peptides, AAV analytical development, small and large RNA analysis including sequence mapping of mRNA by LC/HRMS.
</blockquote>

ThermoFisher Scientific: Method considerations for therapeutic oligonucleotide (ASO) RNA analysis

Method considerations for therapeutic oligonucleotide (ASO) RNA analysis

This webinar will present a successful routine method with optimized HRMS conditions developed for synthetic oligonucleotide impurity analysis.

Method for therapeutic oligonucleotide (ASO) RNA analysis

<a href="https://gcms.labrulez.com/products/1016">Wiley’s KnowItAll software</a> offers integrated solutions to identify, analyze, and manage analytical and chemical data. Combined with comprehensive high-quality spectral reference databases, it provides one of the most advanced technologies available for fast, reliable spectral analysis.
<a href="https://gcms.labrulez.com/products/1016">KnowItAll</a> supports multiple techniques and instrument vendor formats. So whether you use one or more techniques, it can work across a single lab using one instrument or multiple labs with multiple instrument types. Using a vendor neutral solution like KnowItAll is important further in that it future proofs your lab, so even if you add instruments or change vendors your analytical workflow stays intact. 
In this session, we will demonstrate through a series of live examples some of the powerful spectral search tools available within the KnowItAll for unknown spectral analysis in a multi-technique laboratory setting. 
<h5>You will discover:</h5>
<ul>
<li>How KnowItAll offers a consolidated workflow for one or more analytical techniques by combining all the tools needed for spectral analysis and data management into a single, easy-to-use interface. </li>
<li>How to perform an adaptive search to find similar compounds where a fragment group can be present or absent compared to the unknown. </li>
<li>How to perform fast orthogonal searches for unknown spectra within the KnowItAll software and interpret those results. </li>
<li>In addition to our empirical libraries, you will discover how to use a new predicted library to expand the addressable chemical space for spectral identification.</li>
</ul>
This session is recommended for:
<ul>
<li>Scientists and chemists who use multiple laboratory techniques or are interested in learning more about our capabilities. </li>
<li>Professors and students engaged in chemistry and multiple laboratory technique courses or lab work.</li>
</ul>
<blockquote>
Presenter: Dr. Leanna Ergin (Assistant Editor, Wiley Science Solutions)
</blockquote>

Wiley: Introduction to KnowItAll for Multi-Spectral Techniques

Introduction to KnowItAll for Multi-Spectral Techniques

We will demonstrate some of the powerful spectral search tools available within the KnowItAll for unknown spectral analysis in a multi-technique laboratory

A surge in the number of samples can push everyone in the laboratory to their limits. The risk of human error is considerable, especially when complex sample preparation procedures are required and when these procedures are performed manually by different people, such as when staff work in shifts.
In this webinar, Dr. Julian Konsek, Jr. Product Specialist Titration at Metrohm International Headquarters, will show you how to overcome these challenges by automating your routine analysis.
Focusing on titration applications, Julian will present the capabilities of state-of-the- art automation and explain:
<ul>
<li>How automation can systematically reduce the risk of human error</li>
<li>How you can maximise sample throughput</li>
<li>How automation can improve accuracy and reproducibility of your results</li>
<li>How automation can help you better comply with laboratory safety regulations</li>
</ul>
Who should attend?
Lab managers, lab technicians, chemists, and everybody else involved in routine laboratory analysis.
<blockquote>
Presenter: Dr. Julian Konsek (Jr. Product Specialist Titration, Metrohm International Headquarters)
</blockquote>
<blockquote>
Dr. Julian Konsek earned his PhD in 2022 at the University of Konstanz in Physical Chemistry. He joined Metrohm in 2023 as a product specialist for titration automation. Since then, he has gained an extensive experience in automation for all kind of titration systems working for the Competence Center Titration at Metrohm International Headquarters.
</blockquote>

Metrohm: The benefits of automating your titration applications

The benefits of automating your titration applications

In this webinar, we will show you how to overcome challenges associated with titration analysis by state-of-the- art automation.

Key Learning Points:
<ul>
<li>Determine the best SPE sorbent and starting conditions for your analytes in a single run</li>
<li>Conserve valuable lab resources by spending less time developing SPE methods</li>
<li>Learn how to quickly identify SPE conditions for multi-analyte panels</li>
</ul>
<blockquote>
Presenter: Stephanie J. Marin (Clinical and Forensics Global Market Development Manager at Phenomenex)
</blockquote>
<blockquote>
She received her Ph.D. in chemistry from Arizona State University, and has expertise in sample preparation, liquid chromatography and mass spectrometry. She has over 10 years of experience developing and validating clinical methods from her tenure at the ARUP Institute for Clinical and Experimental Pathology. Dr Marin has worked in marketing, product development, and applications development, in addition to customer facing roles in customer and technical support and service and customer education and training. She has also held positions at Hamilton Company, Selerity Technologies and Biotage, and in analytical services for specialty chemicals and polymers at Rohm and Haas (now Dow). She was also a supervisor at an EPA certified laboratory. She is the author of over 30 peer reviewed publications and book chapters and over 100 abstracts presented at national and international meetings. 
</blockquote>

Phenomenex: Effortless Solid Phase Extraction (SPE) Method Development in a Single Experiment

Effortless Solid Phase Extraction (SPE) Method Development in a Single Experiment

Determine the best SPE sorbent and starting conditions for your analytes in a single run.

Solid Phase Extraction (SPE) Method Development

Event Program
<ul>
<li>Loss of water/steam chemistry knowledge and expertise</li>
<li>Most common water/steam quality issues in cogen plants that lead to equipment damage</li>
<li>The ongoing transition from lab to on-line measurements and testing</li>
<li>The commonly overlooked risks of organic contamination to boiler health</li>
</ul>
Practical Tips, Solutions, and Resources to Help Your Cogeneration.
This educational webinar will review emerging trends and challenges in successfully managing water and steam quality that are facing cogeneration power and steam generation (CHP) units. 
Staff responsible for power and steam generation units located within today’s Chemical, Refining, Pulp &amp; Paper, Sugar, Fertilizer, Waste to Energy and other similar type of plants, are looking for ways to learn from others, evolve and improve operational control of their cogeneration processes. 
Valuable take-aways will include tips, solutions and additional resources to the challenges reviewed. Attendees will have an opportunity to ask the presenter questions about the topics covered or anything else related to cogeneration.
Individuals involved in water treatment, boiler and steam quality management, maintenance of water/steam analytics and ensuring operation uptime will find this training helpful.
<blockquote>
Presenter: Kirk Buecher (Director of Power Solutions, METTLER TOLEDO)
</blockquote>
<blockquote>
Kirk Buecher Director of Power Solutions, METTLER TOLEDO Thornton Kirk Buecher has more than 30 years of experience in precision measurement and analysis technologies. For the past 12 years, he has focused on analyzing the chemistry of water used in all types of power and steam generation, including nuclear, biofuel, geothermal, and cogeneration plants. More recently, he has expanded his experience into the requirements for successful green hydrogen generation.
</blockquote>

Mettler-Toledo: Cogen Water Steam Quality Management - Emerging Trends and Challenges

Cogen Water Steam Quality Management - Emerging Trends and Challenges

Emerging trends and challenges in successfully managing water and steam quality that are facing cogeneration power and steam generation (CHP) units.

Cogen Water Steam Quality Management

Event Program
<ul>
<li>Why is it beneficial to automate UV Vis spectroscopic workflows</li>
<li>The available automation solutions for UV Vis spectroscopy</li>
<li>The main benefit of each type of automation</li>
<li>How to chose the right automation for your laboratory</li>
<li>Examples of how automated systems for UV Vis spectroscopy are used in real-life</li>
</ul>
In this live webinar, we will look at how you can streamline the optical spectroscopy workflows in your laboratory to increase efficiency and operating safety, while at the same time improve result quality and help support compliance with regulations.
We will look at what automation solutions are available for UV Vis spectroscopy today and discuss what aspects need to be considered in order to choose the automation solution that best fits your needs.
<h5>Learn more about automation solutions for UV Vis spectroscopy.</h5>
Automation solutions greatly simplify UV Vis spectroscopy workflows and significantly increase productivity in the lab. They enable unattended operation of spectroscopic systems and free lab staff for other tasks, while the system performs the analysis autonomously in the background. Automating spectroscopy solutions means more than just pumping a sample in a cell for the acquisition of a measurement: it comes in many forms and solutions to fit every laboratory&#39;s individual needs.
<blockquote>
Presenter: Anika Adams (Product Manager SPG UV/VIS)
</blockquote>
<blockquote>
Presenter: Dr. Fabian Müller (Product Manager SPG UV/VIS)
</blockquote>

Mettler-Toledo: Automation for UV-Vis Spectroscopy

Automation for UV-Vis Spectroscopy

Learn How to Increase the Efficiency and Security of Your UV Vis Workflows with Unattended Operation.

As global demand for batteries escalates in response to the pressing need to combat climate change, join us in this Digital Classrooms session to uncover Shimadzu’s total solutions to build better batteries.
Delve into three pivotal analytical techniques—ion chromatography (IC), gas chromatography mass spectrometry (GC/GCMS), and mechanical testing—presenting a multifaceted approach to battery testing.
Explore the applications of IC and GC/GCMS in analyzing battery components, detecting impurities, and determining electrolyte composition, as well as understand how MS is rapidly advancing battery development. Moreover, don’t miss out on the essential insights into mechanical evaluation, including compression tests, peel tests, and tensile strength assessments of battery components, to enhance the safety and performance of these lithium-ion batteries.
Discover how Shimadzu&#39;s innovative solutions are creating better batteries for a cleaner tomorrow. Register now.
Learning Objectives:
<ul>
<li>Understand how analytical techniques ensure safe, reliable, and high-performing lithium-ion batteries</li>
<li>Explore the capabilities of IC and GC/GCMS in analyzing battery components and detecting impurities</li>
<li>Learn about the variety of mechanical characterization for lithium-ion batteries</li>
<li>Gain insights into efficient quality control strategies for optimal battery performance and safety</li>
</ul>
<blockquote>
Presenter: Liw Wan Tung (Assistant Manager - LC, Shimadzu Asia Pacific Pte Ltd)
</blockquote>
<blockquote>
Wan Tung is the LC Product Manager and Pharmaceutical market in-charge at Shimadzu Asia Pacific Pte Ltd. She is the LC expert with more than 14 years of working experience in analytical science, specializing in method development of various LC and LCMS applications. In 2012, she joined Shimadzu to develop end-to-end workflow solutions for the customers. She has supported a multitude of applications from impurity analysis to drug discovery and biopharmaceutical applications. Prior to joining Shimadzu, Wan Tung started her professional career as a QAQC chemist in Pharmaceutical multinational company. Wan Tung earned her bachelor’s honour&#39;s degree in chemistry back in 2009.
</blockquote>
<blockquote>
Presenter: Chua Chun Kiang (Senior Product Specialist - GCMS, Shimadzu Asia Pacific)
</blockquote>
<blockquote>
Chun Kiang obtained his PhD from the Nanyang Technological University (NTU) in Singapore. He has a diverse range of experience in analytical and chemical sciences research, including separation science, organic chemistry, electrochemistry and nanomaterials. Prior to joining Shimadzu in 2019, Chun Kiang ventured into the vibrant Singapore tech startup scene. He joined Shimadzu as Senior Application Chemist and subsequently transited to the Product Management of GCMS instrument.
</blockquote>
<blockquote>
Presenter: Kenneth Lee (Senior Product Specialist - Testing, Shimadzu Asia Pacific)
</blockquote>
<blockquote>
Kenneth Lee earned his Master&#39;s degree in material science and engineering from National University of Singapore (NUS). He has more than 10 years of experience in material testing and characterization; currently responsible for product management of Shimadzu testing machines in ASEAN, India &amp; South Asia regions.
</blockquote>

Shimadzu: Powering a Cleaner Tomorrow: Shimadzu's Total Solutions For Lithium-Ion Batteries

Powering a Cleaner Tomorrow: Shimadzu's Total Solutions For Lithium-Ion Batteries

Three pivotal analytical techniques for battery testing - ion chromatography (IC), gas chromatography mass spectrometry (GC/GCMS), and mechanical testing.

Shimadzu's Total Solutions For Lithium-Ion Batteries

<h3>MS School – Fundamentals of Mass Spectrometry Series Part 1</h3>
Mass spectrometry is a powerful analytical technique used to provide valuable information about the composition and structure of molecules. Understanding the fundamentals will empower you to make informed decisions about adding mass spectrometry to your laboratory analyses or maximizing the potential of your current MS systems.
In this educational webinar series, each session will cover a different aspect of mass spectrometry:
Part One: Introduction to mass spectrometry and ionization:
This session will outline the benefits of utilizing mass spectrometry in your analyses, look at the building blocks of the mass spectrometer and how ions are created in the MS source for MS analysis.
<blockquote>
Presenter: Kieron Faherty, Ph.D. (Separations and Mass Spectrometry Field Marketing Manager, Waters Corporation)
</blockquote>
<blockquote>
Kieron Faherty is the Separations and Mass Spectrometry Field Marketing Manager for the Americas at Waters Corporation. He received his B.Sc. (Hons) in Chemistry from the University of Reading (Reading, Berkshire, UK) and his doctorate in Chemistry from the University of Massachusetts (Amherst, MA). He has held several field-based positions during his twenty-plus years at Waters, from Field Service Engineer on both quadrupole and Time-of-Flight MS systems to Principal Field Applications Specialist focused on biopharmaceutical applications.
</blockquote>

Waters Corporation: MS School – Fundamentals of Mass Spectrometry Series

Introduction to mass spectrometry and ionization

This session will outline the benefits of utilizing mass spectrometry in your analyses.

For years, sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) has been the go-to method for protein purity analysis. Despite shortcomings in sensitivity, reproducibility, and its semi-quantitative nature, SDS-PAGE is still widely used.
Capillary electrophoresis (CE-SDS) with its superior separation power, accurate quantitation, and ability for automation is quickly replacing SDS-PAGE in laboratories around the world. In addition to the obvious advantages in time and labor, CE-SDS also stands out as a ‘greener’ method over SDS-PAGE. As laboratories worldwide increasingly focus on waste management with various methods, CE-SDS presents clear advantages over SDS-PAGE for protein purity analysis.​
In this webinar, Prof. Hermann Wätzig from the Institute of Medicinal and Pharmaceutical Chemistry, Braunschweig, Germany and Dr. Chris Heger, Director, Applications Science, Bio-Techne will discuss how transitioning from SDS-PAGE to CE-SDS benefits research, both from an academic and industrial perspective. The speakers will also discuss the current state-of-the art instrumentation and method development landscape.
<blockquote>
Presenter: Dr. Hermann Wätzig (Professor, Technische Universität Braunschweig)
</blockquote>
<blockquote>
Presenter: Dr. Chris Heger (Director, Applications Science, Bio-Techne)
</blockquote>

Wiley: Time to Turn the PAGE on SDS-PAGE!

Time to Turn the PAGE on SDS-PAGE!

Transitioning from SDS-PAGE to CE-SDS benefits research, both from an academic and industrial perspective.