What do chromatography, gemstones, rainbows and even cats have in common? At KNAUER’s latest Girls’ Day in Berlin, 15 schoolgirls explored exactly that question. Through a series of hands-on activities, they discovered how HPLC instruments are developed and manufactured, learned the basics of spectroscopy and chromatography, and met women working across science, engineering, product management and company leadership.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_1_A_student_observes_the_rainbow_spectrum_of_white_light_8ef24d9700.jpeg" alt="KNAUER: Figure 1 A student observes the rainbow spectrum of white light." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_1_A_student_observes_the_rainbow_spectrum_of_white_light_8ef24d9700.jpeg 228w," sizes="100vw" width="624" height="427"><h4>A Day to Explore STEM Careers</h4>Girls’ Future Day, widely known as Girls’ Day, gives schoolgirls across Germany an opportunity to experience professions in which women are still underrepresented. Instead of learning about careers only in the classroom, participants can spend a day inside companies, laboratories and technical workplaces and see what these jobs actually involve.KNAUER has participated in Girls’ Day for 17 years, and demand for places has become consistently high. The attraction is easy to understand: visitors do not simply listen to presentations. They can experiment, assemble components, talk directly with employees and discover how science and engineering are applied in everyday work.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_2_Hands_on_experience_and_wonder_at_Girls_Day_2025_98da525b3a.jpg" alt="KNAUER: Figure 2 - Hands-on experience and wonder at Girls’ Day 2025: 13 interested girls assembled pump heads, learned what HPLC is, and how such equipment is developed" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_2_Hands_on_experience_and_wonder_at_Girls_Day_2025_98da525b3a.jpg 125w," sizes="100vw" width="1024" height="1280"><blockquote>“That moment when the girls realize, with sparkling eyes, just how cool science can be—that’s exactly why I love Girls’ Day. It’s worth every bit of the effort!” – Dr. Kristin Folmert, chemist and product manager at KNAUER</blockquote><h4>From Laboratory Instruments to a Wide Range of Careers</h4>At KNAUER wissenschaftliche Geräte GmbH, laboratory instrumentation is designed, developed, manufactured, tested and marketed from Berlin for customers around the world.That requires far more than chemists alone. The company brings together people working in mechanical production, logistics, media design, mechatronics, software development, science, product management and company management.For the participating girls, this offered a chance to meet women following very different career paths and to see that a technology company can provide opportunities across many disciplines.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_3_The_girls_learned_what_chromatography_and_HPLC_are_a7db4e8eb3.jpg" alt="KNAUER: Figure 3 - The girls learned what chromatography and HPLC are, what they are used for, and how a UV/Vis detector works. They then built their own handheld spectroscope and experimented with white light and various color filters." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_3_The_girls_learned_what_chromatography_and_HPLC_are_a7db4e8eb3.jpg 245w," sizes="100vw" width="1024" height="609"><h4>Women in Science and Technology at KNAUER</h4>Women account for 37% of KNAUER’s workforce, with particularly strong representation in scientific and management positions. The company reports a gender pay gap of 1.84% for 2026, compared with an unadjusted German gender pay gap of 16% in 2025. Women also hold 44% of leadership positions at KNAUER, including several positions performed on a part-time basis.The company emphasizes practical measures intended to make technical careers accessible to a wider range of employees. These include flexible work models, support for childcare and technical solutions such as indoor cranes for handling heavy components.During Girls’ Day, these policies become less abstract. Participants meet scientists, engineers and managers who can describe how they entered their professions and how their careers developed.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_4_During_a_visit_to_the_equipment_development_department_scientist_Thy_Vu_talks_about_her_career_at_KNAUER_3bd9af2786.jpg" alt="KNAUER: Figure 4 - During a visit to the equipment development department, scientist Thy Vu talks about her career at KNAUER. She wrote her bachelor’s thesis here and then worked as a student assistant in development during her master’s program. Subsequent to completing her master’s degree, she accepted a permanent position at KNAUER in the development department. Today, she is developing the pump drive of the future and tells the fascinated girls which gemstones are used in such a pump (sapphires and rubies)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_4_During_a_visit_to_the_equipment_development_department_scientist_Thy_Vu_talks_about_her_career_at_KNAUER_3bd9af2786.jpg 245w," sizes="100vw" width="1024" height="614"><h4>Role Models and First-Hand Career Insights</h4>Several KNAUER employees are also involved in <a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/groups/13080121/">International Women in Chromatography</a>, a network supporting women and non-binary professionals working in chromatography.Throughout the day, the students encountered women at different stages of their careers: from university students and young scientists to experienced product managers, developers and Managing Director Alexandra Knauer.The message was not simply that STEM careers are available to women, but that scientific and technical work can take many forms. Networking, curiosity, willingness to ask questions and confidence in one’s own abilities were recurring themes throughout the event.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_5_A_girl_works_intently_and_with_great_care_on_her_spectroscope_ed94a2a049.jpg" alt="KNAUER: Figure 5 - A girl works intently and with great care on her spectroscope. None of the girls glance at their phones; they are all polite, and many feel comfortable asking questions openly. We are very excited about this generation of bright young talents." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_5_A_girl_works_intently_and_with_great_care_on_her_spectroscope_ed94a2a049.jpg 127w," sizes="100vw" width="405" height="496"><h4>Learning HPLC by Doing</h4>The scientific part of the day began with the basic principles of high-performance liquid chromatography (HPLC).To make separation easier to understand, the group first experimented with light and heavy balls inside a large glass column. From there, the discussion moved to the individual components of an HPLC system.One analogy compared an HPLC instrument with the human body: the pump moves liquid much like the heart circulates blood, separation takes place in the column, and the detector observes the separated compounds through their interaction with light.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_6_The_HPLC_and_its_various_modules_depicted_as_human_organs_855ab67aac.jpg" alt="KNAUER: Figure 6 - The HPLC and its various modules, depicted as human organs." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_6_The_HPLC_and_its_various_modules_depicted_as_human_organs_855ab67aac.jpg 245w," sizes="100vw" width="1210" height="670"><h4>Building a Spectroscope and Seeing Light Differently</h4>Each participant then constructed a small handheld spectroscope.The task required both careful reading and manual dexterity, particularly when fitting the delicate lens. Working together, the girls quickly developed better ways to complete the assembly—a small example of how real development projects evolve through cooperation and continuous improvement.Once finished, the spectroscopes revealed the spectrum of white light as a rainbow together with visible spectral features. Colored filters placed between the light source and the spectroscope then demonstrated how absorption changes the observed spectrum.This connected the practical activity with concepts introduced earlier in the day: visible light, wavelength, absorption and how optical signals eventually become peaks in HPLC detection.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_7_A_11_year_old_girl_gazes_fascinated_at_her_rainbow_4f713de2ae.jpg" alt="KNAUER: Figure 7 - A 11-year-old girl gazes fascinated at her rainbow and notices that while all the colors are visible, some areas are brighter while others are quite dark. “Is the spotlight not pure white, or is my spectroscope absorbing light?” Such clever questions arise when girls are encouraged to explore things for themselves." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_7_A_11_year_old_girl_gazes_fascinated_at_her_rainbow_4f713de2ae.jpg 200w," sizes="100vw" width="1024" height="800"><h4>Inside Instrument Development and Manufacturing</h4>The program then moved from theory into KNAUER’s production environment.In the mechanical manufacturing area, participants saw CNC machines and robotic systems producing precision components for laboratory instruments. They could watch parts of an HPLC pump head taking shape directly from metal components and learn why accurate machining is essential for reliable instrument performance.<blockquote>“This is like science fiction!” – Mariko Stahr, Girls’ Day participant</blockquote>In the development department, engineer Thy Vu demonstrated her work on pump-drive technology and explained how developers investigate parameters such as motor torque. The girls were also able to handle some of the materials used inside an HPLC pump.One detail generated particular interest: components made from sapphire and ruby. This opened a discussion about material properties, crystal structures and why instrument developers benefit from understanding chemistry as well as engineering.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_8_Thomas_Mueller_explains_to_the_girls_how_CNC_machines_mill_the_housing_for_a_pump_head_bd714b9b50.jpg" alt="KNAUER: Figure 8 - Thomas Müller explains to the girls how CNC machines mill the housing for a pump head from a block of metal and why precision is crucial in this process. On the left is one of the robotic arms that continues working even at night, allowing employees to focus solely on daytime work and more demanding tasks. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_8_Thomas_Mueller_explains_to_the_girls_how_CNC_machines_mill_the_housing_for_a_pump_head_bd714b9b50.jpg 245w," sizes="100vw" width="1278" height="468"><h4>Assembling a Real HPLC Pump Head</h4>The final practical station brought the participants into instrument assembly.Each girl was given the opportunity to assemble a pump head herself. The work proved more demanding than it initially appeared, requiring both hands to coordinate several components accurately.With guidance from KNAUER training supervisor Ronald Berger, the participants completed their assemblies before each pump head underwent a final technical check to verify that the pistons moved correctly.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_9_A_girl_is_screwing_the_check_valve_with_the_check_valve_holder_i_cf84fb4375.jpg" alt="KNAUER: Figure 9 - A girl is screwing the check valve with the check valve holder into the pump head. Everything is then tightened using a torque wrench." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_9_A_girl_is_screwing_the_check_valve_with_the_check_valve_holder_i_cf84fb4375.jpg 179w," sizes="100vw" width="376" height="327">The day concluded with lunch and another opportunity to speak with Managing Director Alexandra Knauer, who has long supported initiatives intended to improve the visibility of women and encourage young people to consider STEM careers.Participants received certificates and “I love HPLC” bags with small gifts before leaving KNAUER with their own impressions of what a future in science and technology could look like.<h4>So Where Do the Cats and Rainbows Come In?</h4>The rainbow seen through a spectroscope provides a simple demonstration of the same basic optical principle used in many analytical measurements.When white light is dispersed, its different wavelengths become visible as a spectrum. If part of that light is absorbed by an object or substance, the resulting spectrum changes. Measuring which wavelengths are absorbed can therefore reveal information about the material interacting with the light.The article illustrates the idea with a deliberately simple example: a cat sitting in front of a light source may absorb most of the light, but its silhouette still provides information about what is blocking the beam.Similarly, analytical detectors can obtain information about molecules by measuring how they interact with light.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_10_The_cat_actually_absorbs_all_the_light_af8452f58d.jpg" alt="KNAUER: Figure 10 - The cat actually absorbs all the light, but its outline still lets us know that there’s a fluffy cat sitting there. In HPLC, a[SD5.1] molecule’s light absorption also tells us a great deal about its identity. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_10_The_cat_actually_absorbs_all_the_light_af8452f58d.jpg 236w," sizes="100vw" width="1024" height="676">The same principle also helps explain the colors of evening sunlight. When sunlight travels through a longer path in the atmosphere, shorter-wavelength blue light is scattered more strongly, leaving proportionally more of the longer-wavelength red and orange light reaching the observer.For the students at KNAUER, concepts such as these transformed HPLC and spectroscopy from abstract scientific terminology into something they could build, observe and discuss themselves.And that is ultimately the purpose of Girls’ Day: to show young people that science and technology are not distant subjects confined to textbooks, but fields full of practical questions, creative problem solving and possible future careers.

Girls Just Wanna Have Fun With KNAUER – A Girls' Day Full of Rainbows

Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 21st September 2026? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you application notes by KNAUER and Shimadzu, technical note by Thermo Fisher Scientific and poster by Waters Corporation / SOFT!<h3>1. KNAUER: Precise Catechin Profiling in Various Types of Tea</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/VFD_0198_knauer_precise_catechin_profiling_in_various_types_of_tea_d607cde5ba.pdf">Full PDF for download</a></li></ul>Fresh tea leaves contain high concentrations of catechins, which have many beneficial properties. These include antioxidant, anti-inflammatory as well as antimicrobial effects, and it is even claimed that they have the potential to prevent cancer [1]. In addition, the taste and mouthfeel of a tea strongly depend on its catechin profile. The catechin content of tea leaves varies based on cultivation area, age and variety, as well as on how they are fermented, processed and packed. Therefore, the catechin content is an important marker for the quality of tea.&nbsp;The analysis of catechins can be challenging. The structural similarity of the catechin isomers and other closely related compounds result in similar behavior and a difficult separation (Fig. 1). Catechins possess many phenolic hydroxyl groups, which are prone to secondary interactions, like hydrogen bonding. Classical as well as highly endcapped C18 columns offer only limited retention and selectivity for catechins. Therefore, the KNAUER column portfolio has been expanded to include a pentafluorophenyl (PFP)-modified stationary phase (Eurospher II 100-3 PFP column 50 x 2 mm). It offers optimal separation of the catechins based on hydrophilic, hydrophobic and π-π-interactions. The column withstands acidic eluents (pH 1.5–10) as well as 100 % aqueous conditions, which are beneficial for the retention of hydrophilic compounds. The KNAUER Gradient Prediction Tool assisted with the challenging method development which is described in detail in the TechNote “The Gradient Prediction Tool: Method Development for the Separation of Catechins from Tea”. Here, the application of the optimized method for the identification and quantification of catechins in tea extracts is shown. The seven compounds specified in ISO-14502-2 (2005), as well as two additional catechins known as (+)-gallocatechin and (–)-gallocatechin gallate, were quantified.<h4>MATERIAL AND METHODS</h4><ul><li>Pump: <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2374">P8.1L</a>; high pressure gradient&nbsp;</li><li>Liquid Handler: <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1454">LH 8.1L </a>With FastWash station, and Robotic cooler. Loop: 20 µl.</li><li>Thermostat: <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2376">CT 2.1L&nbsp;</a></li><li>Detector: <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2424">DAD 6.1L&nbsp;</a></li><li>Flow cell: Analytical LightGuide flow cell (50 mm, 6 µl)&nbsp;</li><li>Software: ClarityChrom 10.1</li></ul><h4>CONCLUSION&nbsp;</h4>The application note demonstrates the reliable separation and quantification of catechins and caffeine in tea extracts using the new KNAUER PFP column. Using an optimised gradient predicted with the KNAUER Gradient Prediction Tool, nine tea-related compounds were separated in under 23 minutes. The tested tea samples showed different catechin content highlighting how strongly tea composition depends on the product type and processing.<h3>2. Shimadzu: New Derivatization Method for Quantitative Analysis of Δ⁹-THC-COOH in Urine</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_01_01215_en_c98174629b.pdf">Full PDF for download</a></li></ul><h5>User Benefits</h5><ul><li>The risk of limited availability of stable isotope-labeled standards can be avoided by synthesizing internal standards through derivatization.&nbsp;</li><li>The derivatizing agent IPPAH and its corresponding stable isotope IPPAH-d6 can be synthesized easily and inexpensively from acetone (or acetone-d6).&nbsp;</li><li>This approach achieves sufficient sensitivity and quantitative accuracy for the determination of Δ⁹-THC-COOH in urine.</li></ul>In Japan, the Cannabis Control Act and the Narcotics and Psychotropics Control Act were amended in December 2024. While cannabis was legalized for industrial and medical uses, stricter cannabis regulations have been enacted to prevent harm from its abuse. The primary psychoactive cannabinoid, delta-9-tetrahydrocannabinol (Δ⁹-THC), is extensively metabolized in the body and is excreted mainly in urine and feces as 11-nor-9-carboxy-THC (Δ⁹-THC-COOH) and its glucuronide conjugates. Consequently, Δ⁹-THC-COOH must be analyzed to confirm cannabis use. For LC-MS/MS quantitation, the stable isotope-labeled internal standard Δ⁹-THC-COOH-d3 is commonly used to correct for matrix effects. However, most suppliers of stable isotope standards are located in the U.S., making these standards difficult to obtain due to import procedures. Furthermore, there may be additional importrelated supply risks for stable isotope standards in the future.&nbsp;This Application News describes a technique for quantitating Δ⁹-THC-COOH using an internal standard that is synthesized easily and inexpensively by derivatization with IPPAH (1- isopropylpiperidine carboxylic acid hydrazide), which characteristically reacts with carboxyl groups, and its corresponding stable isotope IPPAH-d6.<h4>Analysis Conditions&nbsp;</h4>LC-MS/MS analysis conditions are shown in Table 1. The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=1&amp;search=Nexera+XR">Nexera XR</a> and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=1&amp;search=LCMS-8050">LCMS-8050 systems</a> were used.<h4>Conclusion&nbsp;</h4>Derivatization with IPPAH and its stable isotope analog, IPPAHd6, enabled the simple and inexpensive preparation of an internal standard. This approach provides sufficient sensitivity and accuracy for the determination of Δ⁹-THC-COOH in urine. Most stable isotope-labeled standards are supplied by foreign manufacturers, creating a risk of delays or difficulties in procurement due to import/export regulations. By synthesizing the internal standard through derivatization, this risk can be minimized.<h3>3. Thermo Fisher Scientific: High-throughput quantitative proteomics with Evosep Eno and the Orbitrap Astral Zoom Mass Spectrometer</h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/tn_004544_ov_astralzoom_evosepeno_htp_proteomics_tn004544_na_en_f31db9084e.pdf">Full PDF for download</a></li></ul>High-throughput proteomics is a critical enabling technology for large clinical studies, high-content drug screening, and systems biology research, allowing for comprehensive and quantitative analysis of complex proteomes across large sample cohorts within practical timeframes. As biological and translational studies expand in scale and complexity, the ability to generate deep and reproducible proteome measurements across thousands of samples has become increasingly essential for robust biomarker discovery, network-level systems modeling, and downstream analyses. In these contexts, accurate and precise protein quantitation must be maintained without sacrificing throughput, placing stringent demands on the performance and robustness of both LC instruments and mass spectrometers.&nbsp;To meet these increasing analytical demands, the Evosep Eno was developed as a high‑throughput LC system that combines robustness, ease of use, and highly reproducible chromatography. It offers six standardized methods: 30, 60, 100, 200, 300, and 500 samples per day (SPD), allowing users to select the throughput that aligns best with their study goals.1 These predefined methods ensure consistent gradient delivery, highly stable retention times, and reproducible system performance across instruments and laboratories.2 By reducing LC‑related variability and simplifying everyday operation, the Evosep Eno offers a strong and consistent foundation for large‑scale proteomics workflows, particularly those relying on short gradients and high reproducibility required for downstream quantitative analysis.<h4>Experiment</h4><h5>Instrumentation&nbsp;</h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=291&amp;search=evosep+eno">Evosep Eno&nbsp;</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1959">Orbitrap Astral Zoom Mass Spectrometer&nbsp;</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2464">Thermo Scientific™ EASY-Spray™ Ion Source&nbsp;</a></li><li>Evosep™ Pod for EASY-Spray Ion Source</li></ul><h5>Software&nbsp;</h5><ul><li>Biognosys Spectronaut® 19.7 software&nbsp;</li><li>MacCoss Lab Software Skyline-Daily V25.1</li></ul><h4>Summary&nbsp;</h4><h5>Seamless and easy integration for high-throughput proteomics&nbsp;</h5>Evosep Eno integrates seamlessly with the Orbitrap Astral Zoom Mass Spectrometer, supported by EASY-Spray source-compatible columns, emitters, and the Evosep Pod column oven for a simple, streamlined, high-throughput workflow.&nbsp;<h5>Deep proteome coverage at 500 SPD&nbsp;</h5>Optimized MS parameters for the standard 500 SPD Evosep Eno gradient enabled identification of more than 6,500 protein groups and 71,000 modified peptides from three replicates of 200 ng Pierce HeLa Digest/PRTC Standard.<h5>Reproducible quantitation across standard gradients&nbsp;</h5>Across all standard Evosep Eno gradients, the workflow delivered highly reproducible label-free quantification, with median protein group %CVs at or below 5.2%, while identifying more than 10,500 protein groups and 190,000 modified peptides from five replicates of 200 ng Pierce HeLa Digest/PRTC Standard at 30 SPD.&nbsp;<h5>Robust chromatography at ultra-high throughput&nbsp;</h5>Chromatographic performance remained stable and robust at 500 SPD, with nearly 100 consecutive runs showing PRTC retention time standard deviations below 0.4 seconds and a median of 6 DPPP.&nbsp;<h5>Strong linearity for confident quantitation&nbsp;</h5>Quantitative performance remained strong at 500 SPD, with PRTC peptides showing excellent linearity across the active gradient (R² &gt;0.98) when spiked from attomolar to femtomolar concentrations.<h3>4. Waters Corporation / SOFT: COMPARATIVE EVALUATION OF HIGH RESOLUTION MASS SPECTROMETRY ACQUISITION STRATEGIES FOR THE DETECTION AND ANALYSIS OF ILLICIT DRUG SUBSTANCES</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/720009592_0bd2b5ee6a.pdf">Full PDF for download</a></li></ul><div><div><section><div><div><div><div><div><div>The poster compares two high-resolution time-of-flight mass spectrometry acquisition strategies for toxicology screening: targeted Tof-MRM and data-independent Tof-MSE, both implemented on a Waters <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1148">Xevo MRT MS</a> coupled to an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/199">ACQUITY UPLC I-Class FTN PLUS System</a>. The aim was to determine whether these approaches could meet routine service requirements for drug testing while also broadening the number of substances that can be detected beyond conventional targeted panels. Urine samples were prepared across a wide concentration range for 20 target analytes, and the methods were also applied to 20 anonymized authentic urine samples.Both workflows used a 15-minute LC separation on an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1952">ACQUITY HSS C18 column</a> under positive electrospray ionization. In the targeted Tof-MRM mode, selected precursor ions were isolated and fragmented, with quantifier and qualifier ions monitored for sensitive quantitative analysis. In contrast, Tof-MSE operated in a data-independent mode, alternating between low and elevated collision energies to collect accurate-mass precursor and fragment-ion information for a broad range of compounds. Data were processed in the waters_connect platform using MS Quan for Tof-MRM and UNIFI with the Waters Toxicology Library, containing more than 2,100 drugs and metabolites, for Tof-MSE.The targeted Tof-MRM method provided the highest sensitivity, with limits of detection ranging from 0.05 to 0.5 ng/mL in fortified urine. The broader Tof-MSE workflow achieved LODs of approximately 0.5 to 5 ng/mL. When both strategies were applied to authentic urine samples, they showed excellent qualitative agreement. Importantly, Tof-MSE detected additional compounds outside the predefined target panel, including commonly encountered medications, benzodiazepines, antidepressants, and illicit drug substances that would not have been captured by the targeted method alone.Overall, the study shows that Tof-MRM can deliver sensitivity comparable to conventional tandem-quadrupole LC-MS/MS for targeted urinary drug analysis, while Tof-MSE adds broader sample characterization and retrospective screening capability. Used together, the two acquisition strategies provide a flexible approach that combines sensitive quantification of predefined analytes with expanded screening for unexpected or previously untargeted drug substances in complex biological samples.</div></div></div></div></div></div></section></div></div>

News from LabRulezLCMS Library - Week 39, 2026

Proper care and maintenance of HPLC columns are essential for getting accurate results and saving on replacement costs. Extending the HPLC column life not only ensures consistent performance but also reduces downtime and the need for frequent replacements.Routine maintenance is equally essential for sustaining column functionality. Correct handling of the column is paramount, ensuring strict compliance with the manufacturer’s specifications regarding pressure, pH, flow rate, and temperature.In the next section, we will explore these best practices in greater detail, offering further guidance on essential HPLC column maintenance strategies. Whether you’re working in a high-throughput lab, or conducting occasional analyses, these strategies will help you get the most out of your <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products?category=48&amp;manufacturerItems=50">HPLC columns</a>.<h3>Essential Guidelines for Extending HPLC Column Life</h3>By adopting these simple yet effective practices, you can greatly extend the HPLC column life while ensuring reliable, high-quality results in your analyses.<h4>Proper Column Handling</h4>HPLC columns should be handled with care to prevent physical damage or shock. The pump should not be started at high flow rates; instead, the flow rate should be gradually increased over several minutes. A pump pressure limit should be set to protect the column from over pressuring, as sudden pressure changes can lead to voids, negatively affecting the column’s performance.<h4>HPLC Column Conditioning and Equilibration</h4>Conditioning is a critical step for preparing a new or stored HPLC column by replacing the storage solvent with the desired mobile phase. Care must be taken to avoid introducing immiscible solvent mixtures into the column. Universally miscible solvents such as THF (tetrahydrofuran) or IPA (isopropyl alcohol) can be useful for this process when moving from normal phase to reversed phase solvent systems. Care must also be taken to ensure that solvents that may be damaging to a specific stationary phase are avoided.For example, if a reversed-phase column experiences phase collapse due to 100% aqueous mobile phases, it should be reactivated. This process involves running 100% acetonitrile at a high flow rate and a temperature as high as 60°C. It is essential to ensure no solid buffers precipitate from residual solvents. Depending on the column condition, between 50 and 100 column volumes are needed for complete reactivation and equilibration, restoring the column’s efficiency for future use.<h4>Optimizing Operating Conditions</h4>Optimizing operating conditions is paramount to enhancing HPLC column efficiency and prolonging their operational lifespan. A fundamental aspect of this is strict adherence to the manufacturer’s recommended temperature, pH and pressure parameters.Deviating from these limits, particularly by operating at elevated temperatures, can significantly hasten the degradation of the stationary phase and hardware, thereby compromising overall performance. Elevated temperatures can also narrow the pH operating range, exacerbating the risk of column degradation through phenomena such as peak broadening or diminished efficiency.Effective pressure management is equally crucial. Sudden pressure surges or mechanical shocks can result in bed voiding, leading to poor chromatographic performance, such as split peaks and reduced separation efficiency. Gradual ramping of flow and pressure, implemented each time the column is initiated, mitigates these risks. Many modern HPLC systems are equipped with automated flow-pressure ramping capabilities, ensuring smoother transitions and reducing the potential for column damage.In addition, vigilant monitoring of the mobile phase's pH is vital to the maintenance of HPLC column integrity. Deviations from the optimal pH range can cause significant harm to the stationary phase. For instance, leads to ligand hydrolysis which leads to a loss of stationary phase functionality and diminished column performance over time. High pH can lead to silica degradation. This weakens the silica structure, causing particle dissolution, void formation, and loss of column efficiency. Maintaining the pH within optimal boundaries is essential for preserving the column’s structural integrity and ensuring consistent chromatographic performance.Furthermore, incorporating inline filters and guard columns into the system serves as a proactive measure to prevent particulates and harsh sample matrices from damaging the analytical column. These preventive tools significantly enhance operational conditions and safeguard the column from contamination, ultimately contributing to extended HPLC column lifetime and reliable performance.<h4>Regular Column Maintenance</h4>Effective routine maintenance is paramount to extending the HPLC column lifetime and ensuring the consistent performance of HPLC columns. A critical aspect of this maintenance is the thorough washing of the column after each use to eliminate residual sample components and mobile phase contaminants.The cleaning process generally involves performing an isocratic or gradient wash using a solvent system similar to the one previously used on the column but substituting the buffer with HPLC-grade water. This helps effectively remove any residual buffer components from the column. This meticulous cleaning process is vital to preventing the accumulation of impurities that could compromise the stationary phase and lead to decreased efficiency over time.Post-cleaning, it is imperative to end-cap the column before storage to prevent the stationary phase from drying out, a condition that can negatively impact the column’s future performance. Proper capping or sealing ensures that the column remains in optimal condition, safeguarding its structural integrity and readiness for subsequent analyses.Additionally, utilizing an older HPLC system as a dedicated wash station can further streamline maintenance practices, freeing up live systems for active use. Consistently adhering to a rigorous cleaning and storage regimen not only enhances the longevity of HPLC columns but also guarantees the delivery of precise and reliable analytical results.For severe contamination or pressure buildup, backflushing may be necessary to dislodge tightly bound contaminants. However, backflushing should only be performed when absolutely necessary, as it can stress the column packing material. It is essential to consult the manufacturer’s instructions before attempting this method.

How to Extend the Lifetime of HPLC Columns?

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<h4>LC-MS/MS fundamentals webinar series 2.0</h4>
Advanced techniques for data acquisition and processing
Elevate your analytical expertise with advanced techniques and workflows
Sharpen your data acquisition and processing skills with our LC-MS/MS 2.0 webinar series. Based on our LC-MS/MS 1.0 webinar series, these sessions will go beyond the fundamentals of LC-MS/MS and introduce ways to advance your analytical methods and data processing workflows.
Every other week, we will explore how to optimize SCIEX OS software with short, 30-minute expert-led presentations.
<h4>This webinar:</h4>
July 2, 2024 11:00 a.m. - 11:30 a.m. CET - Troubleshooting at the source
Acquire the knowledge needed to optimize source parameters and identify and resolve ionization-related problems.
<h4>Other webinars from the series:</h4>
May 7, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.cz/webinar/3820">Beyond the fundamentals</a>
May 21, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3852">Advanced MS/MS method building</a>
Gain insight into advanced features for maximizing sensitivity in your mass spectrometry analyses.
June 4, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3853">Mastering chromatography</a>
Discover how to optimize your chromatography for even the most challenging compounds while creating and building LC methods.
June 18, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3854">It&#39;s a TRAP! Getting the most out of your QTRAP system</a>
Learn when to utilize QTRAP functionality to create more selective and sensitive methods.
July 16, 2024 11:00 a.m. - 11:30 a.m. CET <a href="https://lcms.labrulez.com/webinar/3856">Automating data processing</a>
Learn how to automate your data processing with custom flagging and rules for efficient data review in SCIEX OS software.
July 30, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3857">Excel strategies for mass spectrometry data analysis</a>
Take an in-depth look at when and how to use Excel to increase your productivity.

SCIEX: LC-MS/MS fundamentals webinar series 2.0

Troubleshooting at the source

Elevate your analytical expertise with advanced techniques and workflows.

Troubleshooting at the source in LC-MS/MS

The field of Targeted Protein Degradation (TPD) has emerged as a new therapeutic modality to harness the ubiquitin-proteasome system for targeting proteins that were once considered undruggable through the traditional inhibitor-based modalities.
TPD primarily relies on heterobifunctional molecules like proteolysis-targeting chimeras (PROTACs) and molecular glues to bring the target proteins into proximity to the ubiquitin-proteasome system to induce protein degradation.
Molecular glues are monovalent small molecules with drug-like properties that alter the protein binding surface of E3 ligase, resulting in novel E3 ligase and target protein interactions. Molecular glues are difficult to design and are often discovered retrospectively. 
The rational design and discovery of molecular glues require an untargeted approach to understand the protein ternary complexes, target protein degradation, and ubiquitination induced by potential molecular glues. 
We have leveraged untargeted, high-throughput proteomic approaches to better understand protein-protein interactions and target protein degradation induced by prospective molecular glues. 
The recent developments in the field of high-throughput proteomics due to the introduction of faster and more sensitive mass spectrometers have brought us closer to the rational design and discovery of molecular glues.
Webinar learning objectives:
<ul>
<li>The use of mass spectrometry to perform Targeted Protein Degradation (TPD) studies.</li>
<li>Use of high-throughput proteomic approaches to better understand protein-protein interactions and target protein degradation induced by prospective molecular glues.</li>
<li>Learn about the novel Orbitrap Astral Mass Spectrometer and it&#39;s capabilities.</li>
</ul>
<blockquote>
Presenter: Aman Makaju (Senior Scientist, Amgen, Aman Makaju is a senior scientist in the Discovery Proteomics Group at Amgen Research and Development)
</blockquote>
<blockquote>
In his current capacity, he plays a crucial role in supporting Amgen’s Drug Discovery pipeline through the application of mass spectrometry-based proteomics. Aman is an integral part of a dynamic team that has successfully developed a cutting-edge, high-throughput mass spectrometry-based proteomics platform.
</blockquote>
<blockquote>
This platform has been designed to expedite the discovery process of induced protein proximity modalities, with a particular emphasis on identifying and characterizing molecular glues for targeted protein degradation. The platform&#39;s capabilities include the untargeted identification of glue-induced protein-protein interactions, tracking on- and off-target protein degradation events, and monitoring the ubiquitination of target proteins.
</blockquote>

The Analytical Scientist: Advancing molecular glue discovery through high throughput mass spectrometry based proteomics on Orbitrap Astral mass spectrometer.

Advancing molecular glue discovery through high throughput mass spectrometry based proteomics on Orbitrap Astral mass spectrometer

Learn about the novel Orbitrap Astral Mass Spectrometer and it's capabilities to perform Targeted Protein Degradation (TPD) studies.

Molecular glue discovery by HT proteomics on Orbitrap Astral

Event Overview:
<ul>
<li>Lignin is the world’s most abundant and underutilized source of aromatic biopolymer, produced in vast quantities through various industrial conversion processes. Its molecular structure is very complex with varying characteristic features like functional groups, linkage type, or degree of condensation after industrial isolation. One of the most important characteristics for studies on the application of lignin is its molar mass distribution which will be the focus of this webinar.</li>
<li>A deeper understanding of lignin molecular structure is important for its use as efficient alternative to traditional crude oil-based products.</li>
<li>Classical and emerging methods for molar mass determination of lignin will be discussed. Special emphasis will be on possible problems and pitfalls associated with different types of lignin. </li>
<li>Multi-angle light scattering (MALS) detection, to a large extent, overcomes the limitations of SEC with conventional column calibration. Coupling the MALS detector with an online viscometer allows additional insight into the molecular structure.</li>
</ul>
Key Learning Objectives:
<ul>
<li>Separation principle of size exclusion chromatography (SEC) and limitations of column calibration approach.</li>
<li>Benefits of MALS and viscometry integration to SEC separation.</li>
<li>Pitfalls in SEC for lignin.</li>
</ul>
Who Should Attend:
The webinar is intended for all scientists interested in detailed molar mass characterization of lignins, including technical lignin.

Waters Corporation: Molecular structure of lignin by size exclusion chromatography with advanced detection

Molecular structure of lignin by size exclusion chromatography with advanced detection

The webinar is intended for all scientists interested in detailed molar mass characterization of lignins, including technical lignin.

Molecular structure of lignin by SEC and MALS

Join us for a glimpse into the groundbreaking world of tomorrow’s research labs.
This immersive webinar offers an exclusive glimpse into the groundbreaking technologies shaping the laboratories of tomorrow. Delve into the dynamic fusion of cutting-edge technology and scientific exploration as our visionary experts unveil revolutionary laboratory setups.
Attend this webinar to:
<ul>
<li>Uncover strategies for enhancing the predictability and efficacy of synthetic biology</li>
<li>Navigate the transformative landscape of machine learning and automation in scientific research</li>
<li>Recognize the latest trends and updates in regulatory guidance documents related to data integrity </li>
<li>Attain more comprehensive results with new cutting-edge workflows for peptide and protein characterization</li>
</ul>
<blockquote>
Presenter: Joseph Meeuwsen, PhD (Product Manager ExD, Agilent Technologies)
</blockquote>
<blockquote>
**Presenter:**Sandra Soderholm, PhD (Application Development Scientist, Lab Essentials, Sartorius)
</blockquote>
<blockquote>
**Presenter:**Héctor García Martín, PhD (Staff Scientist, Lawrence Berkley National Lab)
</blockquote>
<blockquote>
**Presenter:**Viktor Kravchuk (Application Specialist Lab Weighing and Digital Solutions, Sartorius)
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<blockquote>
**Presenter:**Christian Klein, PhD (Product Manager LC/Q-TOF, Agilent Technologies)
</blockquote>

Technology Networks: Laboratory of the Future: A Tech Spotlight on the Future of Research

Laboratory of the Future: A Tech Spotlight on the Future of Research

An exclusive glimpse into the groundbreaking technologies shaping the laboratories of tomorrow.

A Tech Spotlight on the Future of Research

ZONTAL and Mestrelab by SciY are leaders in their respective areas of data digitalisation and complex analytical data processing. In this talk we explore how the two products can be seamlessly integrated to add convenience and value. Specifically, we look at how ZONTAL can harness the power of Mnova automated structure verification on data ingestion, and also how end users can use the familiar Mnova desktop application to directly search, access and save to the ZONTAL platform via Mnova Hub. These integrations enhance both products and enable them to be used with even greater efficiency when dealing with complex analytical data like NMR or LCMS.
Agenda
<ul>
<li>An introduction to Sciy</li>
<li>Getting value from scientific data – FAIR data</li>
<li>Getting value from scientific data – getting information and learning from complex data</li>
<li>Examples of seamless integration</li>
<li>Ingestion processing for automated structure elucidation</li>
<li>Ad hoc processing by users in a favoured desktop application</li>
</ul>
Key Learning Points
<ul>
<li>Why a FAIR data platform is important</li>
<li>How we can connect a FAIR data platform to end user applications to solve real laboratory problems</li>
</ul>
<blockquote>
Presenter: Dr. Christof Gaenzler (Director PreSales and Product Marketing)
</blockquote>
<blockquote>
Dr. Gaenzler holds a Doctorate in Molecular Biology from the University of Heidelberg and contributed to the development of the first HPV vaccines during his time at the German Cancer Center in Heidelberg. During his career outside of academia Dr. Gaenzler served as Senior Consultant and PreSales Manager at TIBCO Spotfire, and as the Senior Principal Product Marketing Manager for Biology at PerkinElmer Informatics. Currently, Dr. Gaenzler brings his expertise to ZONTAL as the Director of PreSales and Product Marketing.
</blockquote>
<blockquote>
Presenter: Gary Sharman, PhD (Senior Scientific Director)
</blockquote>
<blockquote>
Gary studied Natural sciences at the University of Cambridge before completing a PhD with prof Dudley Williams on structural and mechanistic studies by NMR and MS. He spent 20 years in the pharmaceutical industry, working in analytical chemistry at AstraZeneca and Eli Lilly, where he developed a particular interest in data flows and visualisations. He moved to Mestrelab in 2020, where his role centres around automation, data processing and customisation.
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Mestrelab Research: SciY Mestrelab Mnova & ZONTAL Join Forces for Next-Level Data Integration

SciY Mestrelab Mnova & ZONTAL Join Forces for Next-Level Data Integration

In this talk we explore how the two products can be seamlessly integrated to add convenience and value.

SciY Mestrelab Mnova & ZONTAL Data Integration

CVS (Cyclic Voltammetric Stripping) is the preferred method for monitoring the concentration of suppressors, brighteners, and levelers used in the production of high-quality printed circuit boards (PCBs) and in advanced packaging of semiconductors. Automating this monitoring can help manufacturers to significantly save time and effort while helping them to keep pace with increasing numbers of samples.
In her webinar, Barbara Zumbrägel, Product Manager Voltammetry at Metrohm International Headquarters, will present the latest technology to take fully automated quality control in PCB manufacturing with CVS to the next level of performance, efficiency, and convenience. Following the webinar, Barbara will be available for a Q&amp;A Session to answer any questions you may have.
Key learnings of this webinar:
<ul>
<li>How automated sample transfer and dosing can make your determination of suppressors, brighteners, and levelers more efficient</li>
<li>How to handle the increasing number of auxiliary solutions with an automated pipetting system</li>
<li>How to optimize your workflow by customizing methods in the viva software to meet the specific requirements of your analysis protocol</li>
</ul>
Who should attend?
<ul>
<li>Lab technicians and lab managers from the PCB, PWB, and semiconductor manufacturing industries</li>
</ul>
<blockquote>
Presenter: Barbara Zumbrägel (Product Manager Voltammetry, Metrohm International Headquarters)
</blockquote>
<blockquote>
Barbara Zumbrägel earned her diploma in chemistry from Technische Universität Clausthal, Germany, and joined Metrohm International Headquarters in 1999 as a product and application specialist for voltammetry. Since 2003, she has also played a significant role in the ongoing development of the Metrohm portfolio of CVS products and applications. In 2006, Barbara was promoted to Product Manager Voltammetry.
</blockquote>

Metrohm: Next level of CVS automation - how to increase the efficiency of your routine analysis

Next level of CVS automation - how to increase the efficiency of your routine analysis

Fully automated quality control in PCB manufacturing with CVS for the next level performance, efficiency, and convenience.

CVS automation - how to increase the efficiency

Embark on a transformative journey with Waters and Scitara in our upcoming webinar, where we illuminate the pathway to authentic digital evolution within laboratory environments. Together, we will navigate the critical landscape of connectivity, seamlessly integrating Waters technologies into the broader lab ecosystem through the innovative Scitara DLX platform.
Join us for an enriching discussion on the strategic advantages of platform integration over point-to-point solutions, the transformative capabilities of Scitara DLX as a robust data conduit within the Waters ecosystem, and the symbiotic relationship between FAIR data principles and AI in platform integration. Discover how this synergy empowers Waters and its customers to unlock unparalleled efficiency, innovation, and collaboration across laboratory workflows.
<blockquote>
Presenter: David Levy (Vice President of Strategy, Partnerships, Scitara)
</blockquote>
<blockquote>
David Levy has 30 years of product and global account management experience in strategic and domestic international software development, product/project management, and sales in the life science marketplace. He has introduced several game-changing products to market while working for Waters Corporation, NuGenesis Technologies Corp., CambridgeSoft Inc., and PerkinElmer Inc. He is currently the Head of Strategy and Partnerships at Scitara Corporation.
</blockquote>
<blockquote>
Presenter: Ben Dearnaley (Product Owner, Cloud Data Analytics, Waters Corporation)
</blockquote>
<blockquote>
Ben has worked at Waters for 17 years, and 14 years in Pharma prior to that.His area of interest as both a customer and at Waters has been on how to leverage Empower meta-data into analytics and Business Intelligence which helps Empower stakeholders understand better how their Laboratories are working, such as understanding system and resource utilisation, laboratory workflows and potential data integrity issues. Ben was a key individual involved with EDS365, and is now working as a Cloud Product Owner with a focus on bringing Empower analytics into the Cloud.
</blockquote>

Waters Corporation: Empowering Digital Transformation: Uniting Waters Technologies with the Lab Ecosystem via Scitara DLX

Empowering Digital Transformation: Uniting Waters Technologies with the Lab Ecosystem via Scitara DLX

Integrating Waters technologies into the broader lab ecosystem through the innovative Scitara DLX platform.

Uniting Waters Tech with Lab Ecosystem via Scitara DLX

Join our latest webinar to find out everything there is to know about SCIEX oil free roughing pumps.
<ul>
<li>How can they improve your lab environment as well as the wider environment?</li>
<li>How can they help minimizing your running costs?</li>
</ul>
Joel Blair, our Global Service and Aftermarket Portfolio manager, will be joining us in this interactive presentation and discussion about SCIEX oil free roughing pumps.

SCIEX: How can you benefit from a SCIEX oil free roughing pump?

How can you benefit from a SCIEX oil free roughing pump?

Interactive presentation and discussion about SCIEX oil free roughing pumps.

The bioprocessing industry has identified an urgent need to intensify downstream operations, making them smaller, faster, and more cost-effective. While numerous technologies and techniques exist to intensify individual unit operations, implementing an integrated next-generation bioprocess presents significant challenges. Our collaboration with Transcenta has culminated in the development of a state-of-the-art, highly automated bioprocessing train for the manufacture of monoclonal antibodies and other biologics.
This webinar will detail the bioprocessing template, operational paradigm, and the complexities involved in qualifying such an advanced manufacturing method.
In this webinar, you will learn:
<ul>
<li>What constitutes an intensified bioprocess,</li>
<li>Transcenta&#39;s template for next-generation bioprocess capability,</li>
<li>The installation and qualification of a multi-column chromatography system and a flow-through polishing system,</li>
<li>Strategies for managing and qualifying long-duration bioprocessing challenges, such as bioburden control.</li>
</ul>
An on-demand version of this webinar will be available after the live event using the same link. Register now and access the webinar at your convenience.
<blockquote>
Presenter: Jerome Dalin (Associate Director – Alliance Management, BioContinuum™ Business Franchise)
</blockquote>
<blockquote>
Jerome Dalin holds an MSc/Engineering degree in Industrial Manufacturing and Biological Engineering. He began his career at Sanofi Pasteur 21 years ago, focusing on vaccine process development in France, Canada &amp; USA. In 2013, Jerome joined our company to manage bioprocessing sales and later transitioned to the Strategy organization to lead global initiatives for vaccines and the Factory of the Future. In his current role, Jerome is at the helm of Alliance Management, driving the development of the BioContinuum™ platform across the biopharmaceutical industry.
</blockquote>
<blockquote>
Presenter: Kara Pizzelli (Downstream Process Strategic Product Manager, Biocontinuum™ Business Franchise)
</blockquote>
<blockquote>
Kara Pizzelli holds a MSc degree in Chemical Engineering. Her career started at our company 25 years ago focusing on the optimization and scale-up of the unit operations from Clarification to Bulk Drug Filtration for customers in the US. Kara more recently managed the global Clarification business, owning the strategy and innovation, before taking on the role of DSP Strategic Product Manager in the Biocontinuum™ Business Franchise in 2023.
</blockquote>
<blockquote>
Presenter: Chris Hwang (EVP, CTO, Transcenta)
</blockquote>
<blockquote>
Chris Hwang holds a Ph.D. in Biochemical Engineering from MIT and has over 30 years of experience in the biopharmaceutical industry. He began his career at Genzyme and later at Sanofi, supporting and leading CMC development as well as process and technology development. He also served as project lead for the Integrated Continuous Biomanufacturing platform program. Chris joined HJB/Transcenta in 2016, where he is responsible for CMC development and developing and industrializing highly intensified biomanufacturing platforms to increase facility output, enhance process control, and reduce the cost of goods to expand patient access to innovative biologics.
</blockquote>
<blockquote>
Presenter: Jewell Zhou (Lead Scientist – CMC Process Development, Downstream Platform, Transcenta)
</blockquote>
<blockquote>
Jewell Zhou holds a Msc/Engineer degree in Biology and Bioprocessing Engineering. He joined the HJB company in 2018 as a scientist to develop downstream purification process for CMC. Since 2020, he joined the HJB HiCB group and started to build and support continuous purification platform for advanced antibody manufacturing. In his current role, Jewell is working on HICB/Transcenta platform development and supporting continuous manufacturing control strategy.
</blockquote>
<blockquote>
Presenter: Dr. Paul Beckett (Senior Strategic Product Manager – Clarification and Chromatography GTM Lead)
</blockquote>
<blockquote>
Paul holds a bachelor’s degree in biochemistry from Imperial College London and has a master’s degree and doctorate in biochemical engineering from University College London. Paul has worked in the pharmaceutical industry for 20 years and has held a number of roles in this capacity, including managing bioprocesses for early phase clinical material, CMC regulatory affairs consultancy and programme management of the next generation bioprocessing initiative. His current role is the global GTM lead for the chromatography and clarification technologies at our company.
</blockquote>

Merck: Collaborative Bioprocessing: Next-Gen mAb Downstream Manufacturing Enhanced by Transcenta Partnership

Collaborative Bioprocessing: Next-Gen mAb Downstream Manufacturing Enhanced by Transcenta Partnership

This webinar will detail the bioprocessing template, operational paradigm, and the complexities involved in qualifying such an advanced manufacturing method.

Next-Gen mAb Manufacturing in Partnership with Transcenta

ZONTAL and Mestrelab by SciY are leaders in their respective areas of data digitalisation and complex analytical data processing.In this talk we explore how the two products can be seamlessly integrated to add convenience and value. Specifically, we look at how ZONTAL can harness the power of Mnova automated structure verification on data ingestion, and also how end users can use the familiar Mnova desktop application to directly search, access and save to the ZONTAL platform via Mnova Hub.These integrations enhance both products and enable them to be used with even greater efficiency when dealing with complex analytical data like NMR or LCMS.<blockquote>Presenter: Dr. Christof Gaenzler (Director PreSales and Product Marketing - Zontal)Dr. Gaenzler holds a Doctorate in Molecular Biology from the University of Heidelberg and contributed to the development of the first HPV vaccines during his time at the German Cancer Center in Heidelberg. During his career outside of academia Dr. Gaenzler served as Senior Consultant and PreSales Manager at TIBCO Spotfire, and as the Senior Principal Product Marketing Manager for Biology at PerkinElmer Informatics. Currently, Dr. Gaenzler brings his expertise to ZONTAL as the Director of PreSales and Product Marketing.Presenter: Gary Sharman, PhD (Senior Scientific Director)Gary studied Natural sciences at the University of Cambridge before completing a PhD with prof Dudley Williams on structural and mechanistic studies by NMR and MS. He spent 20 years in the pharmaceutical industry, working in analytical chemistry at AstraZeneca and Eli Lilly, where he developed a particular interest in data flows and visualisations. He moved to Mestrelab in 2020, where his role centres around automation, data processing and customisation.</blockquote>

Mestrelab Research: SciY Mestrelab Mnova & ZONTAL Join Forces

SciY Mestrelab Mnova & ZONTAL Join Forces for Next-Level Data Integration 

In this talk we explore how the ZONTAL and Mestrelab products can be seamlessly integrated.

How can you benefit from a SCIEX oil free roughing pump?

Molecular structure of lignin by size exclusion chromatography with advanced detection

Troubleshooting at the source

Laboratory of the Future: A Tech Spotlight on the Future of Research

Advancing molecular glue discovery through high throughput mass spectrometry based proteomics on Orbitrap Astral mass spectrometer

SciY Mestrelab Mnova & ZONTAL Join Forces for Next-Level Data Integration

Collaborative Bioprocessing: Next-Gen mAb Downstream Manufacturing Enhanced by Transcenta Partnership

Empowering Digital Transformation: Uniting Waters Technologies with the Lab Ecosystem via Scitara DLX

Next level of CVS automation - how to increase the efficiency of your routine analysis

SciY Mestrelab Mnova & ZONTAL Join Forces for Next-Level Data Integration

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