<p><strong>What do chromatography, gemstones, rainbows and even cats have in common? At KNAUER’s latest Girls’ Day in Berlin, 15 schoolgirls explored exactly that question. Through a series of hands-on activities, they discovered how HPLC instruments are developed and manufactured, learned the basics of spectroscopy and chromatography, and met women working across science, engineering, product management and company leadership.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_1_A_student_observes_the_rainbow_spectrum_of_white_light_8ef24d9700.jpeg" alt="KNAUER: Figure 1 A student observes the rainbow spectrum of white light." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_1_A_student_observes_the_rainbow_spectrum_of_white_light_8ef24d9700.jpeg 228w," sizes="100vw" width="624" height="427"></p><h4><strong>A Day to Explore STEM Careers</strong></h4><p>Girls’ Future Day, widely known as <strong>Girls’ Day</strong>, gives schoolgirls across Germany an opportunity to experience professions in which women are still underrepresented. Instead of learning about careers only in the classroom, participants can spend a day inside companies, laboratories and technical workplaces and see what these jobs actually involve.</p><p>KNAUER has participated in Girls’ Day for <strong>17 years</strong>, and demand for places has become consistently high. The attraction is easy to understand: visitors do not simply listen to presentations. They can experiment, assemble components, talk directly with employees and discover how science and engineering are applied in everyday work.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_2_Hands_on_experience_and_wonder_at_Girls_Day_2025_98da525b3a.jpg" alt="KNAUER: Figure 2 - Hands-on experience and wonder at Girls’ Day 2025: 13 interested girls assembled pump heads, learned what HPLC is, and how such equipment is developed" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_2_Hands_on_experience_and_wonder_at_Girls_Day_2025_98da525b3a.jpg 125w," sizes="100vw" width="1024" height="1280"></p><blockquote><p><i><strong>“That moment when the girls realize, with sparkling eyes, just how cool science can be—that’s exactly why I love Girls’ Day. It’s worth every bit of the effort!” – Dr. Kristin Folmert, chemist and product manager at KNAUER</strong></i></p></blockquote><h4><strong>From Laboratory Instruments to a Wide Range of Careers</strong></h4><p>At <strong>KNAUER wissenschaftliche Geräte GmbH</strong>, laboratory instrumentation is designed, developed, manufactured, tested and marketed from Berlin for customers around the world.</p><p>That requires far more than chemists alone. The company brings together people working in mechanical production, logistics, media design, mechatronics, software development, science, product management and company management.</p><p>For the participating girls, this offered a chance to meet women following very different career paths and to see that a technology company can provide opportunities across many disciplines.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_3_The_girls_learned_what_chromatography_and_HPLC_are_a7db4e8eb3.jpg" alt="KNAUER: Figure 3 - The girls learned what chromatography and HPLC are, what they are used for, and how a UV/Vis detector works. They then built their own handheld spectroscope and experimented with white light and various color filters." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_3_The_girls_learned_what_chromatography_and_HPLC_are_a7db4e8eb3.jpg 245w," sizes="100vw" width="1024" height="609"></p><h4><strong>Women in Science and Technology at KNAUER</strong></h4><p>Women account for <strong>37% of KNAUER’s workforce</strong>, with particularly strong representation in scientific and management positions. The company reports a <strong>gender pay gap of 1.84% for 2026</strong>, compared with an unadjusted German gender pay gap of 16% in 2025. Women also hold <strong>44% of leadership positions</strong> at KNAUER, including several positions performed on a part-time basis.</p><p>The company emphasizes practical measures intended to make technical careers accessible to a wider range of employees. These include flexible work models, support for childcare and technical solutions such as indoor cranes for handling heavy components.</p><p>During Girls’ Day, these policies become less abstract. Participants meet scientists, engineers and managers who can describe how they entered their professions and how their careers developed.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_4_During_a_visit_to_the_equipment_development_department_scientist_Thy_Vu_talks_about_her_career_at_KNAUER_3bd9af2786.jpg" alt="KNAUER: Figure 4 - During a visit to the equipment development department, scientist Thy Vu talks about her career at KNAUER. She wrote her bachelor’s thesis here and then worked as a student assistant in development during her master’s program. Subsequent to completing her master’s degree, she accepted a permanent position at KNAUER in the development department. Today, she is developing the pump drive of the future and tells the fascinated girls which gemstones are used in such a pump (sapphires and rubies)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_4_During_a_visit_to_the_equipment_development_department_scientist_Thy_Vu_talks_about_her_career_at_KNAUER_3bd9af2786.jpg 245w," sizes="100vw" width="1024" height="614"></p><h4><strong>Role Models and First-Hand Career Insights</strong></h4><p>Several KNAUER employees are also involved in <a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/groups/13080121/">International Women in Chromatography</a>, a network supporting women and non-binary professionals working in chromatography.</p><p>Throughout the day, the students encountered women at different stages of their careers: from university students and young scientists to experienced product managers, developers and Managing Director Alexandra Knauer.</p><p>The message was not simply that STEM careers are available to women, but that scientific and technical work can take many forms. Networking, curiosity, willingness to ask questions and confidence in one’s own abilities were recurring themes throughout the event.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_5_A_girl_works_intently_and_with_great_care_on_her_spectroscope_ed94a2a049.jpg" alt="KNAUER: Figure 5 - A girl works intently and with great care on her spectroscope. None of the girls glance at their phones; they are all polite, and many feel comfortable asking questions openly. We are very excited about this generation of bright young talents." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_5_A_girl_works_intently_and_with_great_care_on_her_spectroscope_ed94a2a049.jpg 127w," sizes="100vw" width="405" height="496"></p><h4><strong>Learning HPLC by Doing</strong></h4><p>The scientific part of the day began with the basic principles of <strong>high-performance liquid chromatography (HPLC)</strong>.</p><p>To make separation easier to understand, the group first experimented with light and heavy balls inside a large glass column. From there, the discussion moved to the individual components of an HPLC system.</p><p>One analogy compared an HPLC instrument with the human body: the <strong>pump</strong> moves liquid much like the heart circulates blood, separation takes place in the <strong>column</strong>, and the <strong>detector</strong> observes the separated compounds through their interaction with light.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_6_The_HPLC_and_its_various_modules_depicted_as_human_organs_855ab67aac.jpg" alt="KNAUER: Figure 6 - The HPLC and its various modules, depicted as human organs." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_6_The_HPLC_and_its_various_modules_depicted_as_human_organs_855ab67aac.jpg 245w," sizes="100vw" width="1210" height="670"></p><h4><strong>Building a Spectroscope and Seeing Light Differently</strong></h4><p>Each participant then constructed a small handheld spectroscope.</p><p>The task required both careful reading and manual dexterity, particularly when fitting the delicate lens. Working together, the girls quickly developed better ways to complete the assembly—a small example of how real development projects evolve through cooperation and continuous improvement.</p><p>Once finished, the spectroscopes revealed the spectrum of white light as a rainbow together with visible spectral features. Colored filters placed between the light source and the spectroscope then demonstrated how absorption changes the observed spectrum.</p><p>This connected the practical activity with concepts introduced earlier in the day: visible light, wavelength, absorption and how optical signals eventually become peaks in HPLC detection.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_7_A_11_year_old_girl_gazes_fascinated_at_her_rainbow_4f713de2ae.jpg" alt="KNAUER: Figure 7 - A 11-year-old girl gazes fascinated at her rainbow and notices that while all the colors are visible, some areas are brighter while others are quite dark. “Is the spotlight not pure white, or is my spectroscope absorbing light?” Such clever questions arise when girls are encouraged to explore things for themselves." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_7_A_11_year_old_girl_gazes_fascinated_at_her_rainbow_4f713de2ae.jpg 200w," sizes="100vw" width="1024" height="800"></p><h4><strong>Inside Instrument Development and Manufacturing</strong></h4><p>The program then moved from theory into KNAUER’s production environment.</p><p>In the mechanical manufacturing area, participants saw CNC machines and robotic systems producing precision components for laboratory instruments. They could watch parts of an HPLC pump head taking shape directly from metal components and learn why accurate machining is essential for reliable instrument performance.</p><blockquote><p><i>“This is like science fiction!” – Mariko Stahr, Girls’ Day participant</i></p></blockquote><p>In the development department, engineer Thy Vu demonstrated her work on pump-drive technology and explained how developers investigate parameters such as motor torque. The girls were also able to handle some of the materials used inside an HPLC pump.</p><p>One detail generated particular interest: components made from <strong>sapphire and ruby</strong>. This opened a discussion about material properties, crystal structures and why instrument developers benefit from understanding chemistry as well as engineering.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_8_Thomas_Mueller_explains_to_the_girls_how_CNC_machines_mill_the_housing_for_a_pump_head_bd714b9b50.jpg" alt="KNAUER: Figure 8 - Thomas Müller explains to the girls how CNC machines mill the housing for a pump head from a block of metal and why precision is crucial in this process. On the left is one of the robotic arms that continues working even at night, allowing employees to focus solely on daytime work and more demanding tasks. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_8_Thomas_Mueller_explains_to_the_girls_how_CNC_machines_mill_the_housing_for_a_pump_head_bd714b9b50.jpg 245w," sizes="100vw" width="1278" height="468"></p><h4><strong>Assembling a Real HPLC Pump Head</strong></h4><p>The final practical station brought the participants into instrument assembly.</p><p>Each girl was given the opportunity to assemble a pump head herself. The work proved more demanding than it initially appeared, requiring both hands to coordinate several components accurately.</p><p>With guidance from KNAUER training supervisor Ronald Berger, the participants completed their assemblies before each pump head underwent a final technical check to verify that the pistons moved correctly.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_9_A_girl_is_screwing_the_check_valve_with_the_check_valve_holder_i_cf84fb4375.jpg" alt="KNAUER: Figure 9 - A girl is screwing the check valve with the check valve holder into the pump head. Everything is then tightened using a torque wrench." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_9_A_girl_is_screwing_the_check_valve_with_the_check_valve_holder_i_cf84fb4375.jpg 179w," sizes="100vw" width="376" height="327"></p><p>The day concluded with lunch and another opportunity to speak with Managing Director Alexandra Knauer, who has long supported initiatives intended to improve the visibility of women and encourage young people to consider STEM careers.</p><p>Participants received certificates and “I love HPLC” bags with small gifts before leaving KNAUER with their own impressions of what a future in science and technology could look like.</p><h4><strong>So Where Do the Cats and Rainbows Come In?</strong></h4><p>The rainbow seen through a spectroscope provides a simple demonstration of the same basic optical principle used in many analytical measurements.</p><p>When white light is dispersed, its different wavelengths become visible as a spectrum. If part of that light is absorbed by an object or substance, the resulting spectrum changes. Measuring which wavelengths are absorbed can therefore reveal information about the material interacting with the light.</p><p>The article illustrates the idea with a deliberately simple example: a cat sitting in front of a light source may absorb most of the light, but its silhouette still provides information about what is blocking the beam.</p><p>Similarly, analytical detectors can obtain information about molecules by measuring how they interact with light.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_10_The_cat_actually_absorbs_all_the_light_af8452f58d.jpg" alt="KNAUER: Figure 10 - The cat actually absorbs all the light, but its outline still lets us know that there’s a fluffy cat sitting there. In HPLC, a[SD5.1] molecule’s light absorption also tells us a great deal about its identity. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_10_The_cat_actually_absorbs_all_the_light_af8452f58d.jpg 236w," sizes="100vw" width="1024" height="676"></p><p>The same principle also helps explain the colors of evening sunlight. When sunlight travels through a longer path in the atmosphere, shorter-wavelength blue light is scattered more strongly, leaving proportionally more of the longer-wavelength red and orange light reaching the observer.</p><p>For the students at KNAUER, concepts such as these transformed HPLC and spectroscopy from abstract scientific terminology into something they could build, observe and discuss themselves.</p><p>And that is ultimately the purpose of Girls’ Day: to show young people that science and technology are not distant subjects confined to textbooks, but fields full of practical questions, creative problem solving and possible future careers.</p>

Girls Just Wanna Have Fun With KNAUER – A Girls' Day Full of Rainbows

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 21st September 2026? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>KNAUER </strong>and<strong> Shimadzu, </strong>technical note by <strong>Thermo Fisher Scientific </strong>and poster by <strong>Waters Corporation / SOFT!</strong></p><h3><strong>1. KNAUER: Precise Catechin Profiling in Various Types of Tea</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/VFD_0198_knauer_precise_catechin_profiling_in_various_types_of_tea_d607cde5ba.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Fresh tea leaves contain high concentrations of catechins, which have many beneficial properties. These include antioxidant, anti-inflammatory as well as antimicrobial effects, and it is even claimed that they have the potential to prevent cancer [1]. In addition, the taste and mouthfeel of a tea strongly depend on its catechin profile. The catechin content of tea leaves varies based on cultivation area, age and variety, as well as on how they are fermented, processed and packed. Therefore, the catechin content is an important marker for the quality of tea.&nbsp;</p><p>The analysis of catechins can be challenging. The structural similarity of the catechin isomers and other closely related compounds result in similar behavior and a difficult separation (Fig. 1). Catechins possess many phenolic hydroxyl groups, which are prone to secondary interactions, like hydrogen bonding. Classical as well as highly endcapped C18 columns offer only limited retention and selectivity for catechins. Therefore, the KNAUER column portfolio has been expanded to include a pentafluorophenyl (PFP)-modified stationary phase (<strong>Eurospher II 100-3 PFP column </strong>50 x 2 mm). It offers optimal separation of the catechins based on hydrophilic, hydrophobic and π-π-interactions. The column withstands acidic eluents (pH 1.5–10) as well as 100 % aqueous conditions, which are beneficial for the retention of hydrophilic compounds. The KNAUER Gradient Prediction Tool assisted with the challenging method development which is described in detail in the TechNote “The Gradient Prediction Tool: Method Development for the Separation of Catechins from Tea”. Here, the application of the optimized method for the identification and quantification of catechins in tea extracts is shown. The seven compounds specified in ISO-14502-2 (2005), as well as two additional catechins known as (+)-gallocatechin and (–)-gallocatechin gallate, were quantified.</p><h4><strong>MATERIAL AND METHODS</strong></h4><ul><li><strong>Pump: </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2374"><strong>P8.1L</strong></a>; high pressure gradient&nbsp;</li><li><strong>Liquid Handler:</strong> <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1454"><strong>LH 8.1L </strong></a>With FastWash station, and Robotic cooler. Loop: 20 µl.</li><li><strong>Thermostat: </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2376"><strong>CT 2.1L&nbsp;</strong></a></li><li><strong>Detector:</strong> <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2424"><strong>DAD 6.1L&nbsp;</strong></a></li><li><strong>Flow cell: </strong>Analytical LightGuide flow cell (50 mm, 6 µl)&nbsp;</li><li><strong>Software:</strong> ClarityChrom 10.1</li></ul><h4><strong>CONCLUSION&nbsp;</strong></h4><p>The application note demonstrates the reliable separation and quantification of catechins and caffeine in tea extracts using the new KNAUER PFP column. Using an optimised gradient predicted with the KNAUER Gradient Prediction Tool, nine tea-related compounds were separated in under 23 minutes. The tested tea samples showed different catechin content highlighting how strongly tea composition depends on the product type and processing.</p><h3><strong>2. Shimadzu: New Derivatization Method for Quantitative Analysis of Δ⁹-THC-COOH in Urine</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_01_01215_en_c98174629b.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>The risk of limited availability of stable isotope-labeled standards can be avoided by synthesizing internal standards through derivatization.&nbsp;</li><li>The derivatizing agent IPPAH and its corresponding stable isotope IPPAH-d6 can be synthesized easily and inexpensively from acetone (or acetone-d6).&nbsp;</li><li>This approach achieves sufficient sensitivity and quantitative accuracy for the determination of Δ⁹-THC-COOH in urine.</li></ul><p>In Japan, the Cannabis Control Act and the Narcotics and Psychotropics Control Act were amended in December 2024. While cannabis was legalized for industrial and medical uses, stricter cannabis regulations have been enacted to prevent harm from its abuse. The primary psychoactive cannabinoid, delta-9-tetrahydrocannabinol (Δ⁹-THC), is extensively metabolized in the body and is excreted mainly in urine and feces as 11-nor-9-carboxy-THC (Δ⁹-THC-COOH) and its glucuronide conjugates. Consequently, Δ⁹-THC-COOH must be analyzed to confirm cannabis use. For LC-MS/MS quantitation, the stable isotope-labeled internal standard Δ⁹-THC-COOH-d3 is commonly used to correct for matrix effects. However, most suppliers of stable isotope standards are located in the U.S., making these standards difficult to obtain due to import procedures. Furthermore, there may be additional importrelated supply risks for stable isotope standards in the future.&nbsp;</p><p>This Application News describes a technique for quantitating Δ⁹-THC-COOH using an internal standard that is synthesized easily and inexpensively by derivatization with IPPAH (1- isopropylpiperidine carboxylic acid hydrazide), which characteristically reacts with carboxyl groups, and its corresponding stable isotope IPPAH-d6.</p><h4><strong>Analysis Conditions&nbsp;</strong></h4><p>LC-MS/MS analysis conditions are shown in Table 1. The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=1&amp;search=Nexera+XR"><strong>Nexera XR</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=1&amp;search=LCMS-8050"><strong>LCMS-8050 systems</strong></a> were used.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>Derivatization with IPPAH and its stable isotope analog, IPPAHd6, enabled the simple and inexpensive preparation of an internal standard. This approach provides sufficient sensitivity and accuracy for the determination of Δ⁹-THC-COOH in urine. Most stable isotope-labeled standards are supplied by foreign manufacturers, creating a risk of delays or difficulties in procurement due to import/export regulations. By synthesizing the internal standard through derivatization, this risk can be minimized.</p><h3><strong>3. Thermo Fisher Scientific: High-throughput quantitative proteomics with Evosep Eno and the Orbitrap Astral Zoom Mass Spectrometer</strong></h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/tn_004544_ov_astralzoom_evosepeno_htp_proteomics_tn004544_na_en_f31db9084e.pdf"><strong>Full PDF for download</strong></a></li></ul><p>High-throughput proteomics is a critical enabling technology for large clinical studies, high-content drug screening, and systems biology research, allowing for comprehensive and quantitative analysis of complex proteomes across large sample cohorts within practical timeframes. As biological and translational studies expand in scale and complexity, the ability to generate deep and reproducible proteome measurements across thousands of samples has become increasingly essential for robust biomarker discovery, network-level systems modeling, and downstream analyses. In these contexts, accurate and precise protein quantitation must be maintained without sacrificing throughput, placing stringent demands on the performance and robustness of both LC instruments and mass spectrometers.&nbsp;</p><p>To meet these increasing analytical demands, the Evosep Eno was developed as a high‑throughput LC system that combines robustness, ease of use, and highly reproducible chromatography. It offers six standardized methods: 30, 60, 100, 200, 300, and 500 samples per day (SPD), allowing users to select the throughput that aligns best with their study goals.1 These predefined methods ensure consistent gradient delivery, highly stable retention times, and reproducible system performance across instruments and laboratories.2 By reducing LC‑related variability and simplifying everyday operation, the Evosep Eno offers a strong and consistent foundation for large‑scale proteomics workflows, particularly those relying on short gradients and high reproducibility required for downstream quantitative analysis.</p><h4><strong>Experiment</strong></h4><h5><strong>Instrumentation&nbsp;</strong></h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=291&amp;search=evosep+eno"><strong>Evosep Eno&nbsp;</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1959"><strong>Orbitrap Astral Zoom Mass Spectrometer&nbsp;</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2464"><strong>Thermo Scientific™ EASY-Spray™ Ion Source&nbsp;</strong></a></li><li>Evosep™ Pod for EASY-Spray Ion Source</li></ul><h5><strong>Software&nbsp;</strong></h5><ul><li>Biognosys Spectronaut® 19.7 software&nbsp;</li><li>MacCoss Lab Software Skyline-Daily V25.1</li></ul><h4><strong>Summary&nbsp;</strong></h4><h5><strong>Seamless and easy integration for high-throughput proteomics&nbsp;</strong></h5><p>Evosep Eno integrates seamlessly with the Orbitrap Astral Zoom Mass Spectrometer, supported by EASY-Spray source-compatible columns, emitters, and the Evosep Pod column oven for a simple, streamlined, high-throughput workflow.&nbsp;</p><h5><strong>Deep proteome coverage at 500 SPD&nbsp;</strong></h5><p>Optimized MS parameters for the standard 500 SPD Evosep Eno gradient enabled identification of more than 6,500 protein groups and 71,000 modified peptides from three replicates of 200 ng Pierce HeLa Digest/PRTC Standard.</p><h5><strong>Reproducible quantitation across standard gradients&nbsp;</strong></h5><p>Across all standard Evosep Eno gradients, the workflow delivered highly reproducible label-free quantification, with median protein group %CVs at or below 5.2%, while identifying more than 10,500 protein groups and 190,000 modified peptides from five replicates of 200 ng Pierce HeLa Digest/PRTC Standard at 30 SPD.&nbsp;</p><h5><strong>Robust chromatography at ultra-high throughput&nbsp;</strong></h5><p>Chromatographic performance remained stable and robust at 500 SPD, with nearly 100 consecutive runs showing PRTC retention time standard deviations below 0.4 seconds and a median of 6 DPPP.&nbsp;</p><h5><strong>Strong linearity for confident quantitation&nbsp;</strong></h5><p>Quantitative performance remained strong at 500 SPD, with PRTC peptides showing excellent linearity across the active gradient (R² &gt;0.98) when spiked from attomolar to femtomolar concentrations.</p><h3><strong>4. Waters Corporation / SOFT: COMPARATIVE EVALUATION OF HIGH RESOLUTION MASS SPECTROMETRY ACQUISITION STRATEGIES FOR THE DETECTION AND ANALYSIS OF ILLICIT DRUG SUBSTANCES</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/720009592_0bd2b5ee6a.pdf"><strong>Full PDF for download</strong></a></li></ul><div><div><section><div><div><div><div><div><div><p>The poster compares two high-resolution time-of-flight mass spectrometry acquisition strategies for toxicology screening: targeted <strong>Tof-MRM</strong> and data-independent <strong>Tof-MSE</strong>, both implemented on a Waters <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1148"><strong>Xevo MRT MS</strong></a> coupled to an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/199"><strong>ACQUITY UPLC I-Class FTN PLUS System</strong></a>. The aim was to determine whether these approaches could meet routine service requirements for drug testing while also broadening the number of substances that can be detected beyond conventional targeted panels. Urine samples were prepared across a wide concentration range for 20 target analytes, and the methods were also applied to 20 anonymized authentic urine samples.</p><p>Both workflows used a 15-minute LC separation on an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1952"><strong>ACQUITY HSS C18 column</strong></a> under positive electrospray ionization. In the targeted Tof-MRM mode, selected precursor ions were isolated and fragmented, with quantifier and qualifier ions monitored for sensitive quantitative analysis. In contrast, Tof-MSE operated in a data-independent mode, alternating between low and elevated collision energies to collect accurate-mass precursor and fragment-ion information for a broad range of compounds. Data were processed in the waters_connect platform using MS Quan for Tof-MRM and UNIFI with the Waters Toxicology Library, containing more than 2,100 drugs and metabolites, for Tof-MSE.</p><p>The targeted Tof-MRM method provided the highest sensitivity, with limits of detection ranging from <strong>0.05 to 0.5 ng/mL</strong> in fortified urine. The broader Tof-MSE workflow achieved LODs of approximately <strong>0.5 to 5 ng/mL</strong>. When both strategies were applied to authentic urine samples, they showed excellent qualitative agreement. Importantly, Tof-MSE detected additional compounds outside the predefined target panel, including commonly encountered medications, benzodiazepines, antidepressants, and illicit drug substances that would not have been captured by the targeted method alone.</p><p>Overall, the study shows that Tof-MRM can deliver sensitivity comparable to conventional tandem-quadrupole LC-MS/MS for targeted urinary drug analysis, while Tof-MSE adds broader sample characterization and retrospective screening capability. Used together, the two acquisition strategies provide a flexible approach that combines sensitive quantification of predefined analytes with expanded screening for unexpected or previously untargeted drug substances in complex biological samples.</p></div></div></div></div></div></div></section></div></div>

News from LabRulezLCMS Library - Week 39, 2026

<p><strong>Proper care and maintenance of HPLC columns are essential for getting accurate results and saving on replacement costs. Extending the HPLC column life not only ensures consistent performance but also reduces downtime and the need for frequent replacements.</strong></p><p>Routine maintenance is equally essential for sustaining column functionality. Correct handling of the column is paramount, ensuring strict compliance with the manufacturer’s specifications regarding pressure, pH, flow rate, and temperature.</p><p>In the next section, we will explore these best practices in greater detail, offering further guidance on essential HPLC column maintenance strategies. Whether you’re working in a high-throughput lab, or conducting occasional analyses, these strategies will help you get the most out of your<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products?category=48&amp;manufacturerItems=50"><strong>HPLC columns</strong></a>.</p><h3><strong>Essential Guidelines for Extending HPLC Column Life</strong></h3><p>By adopting these simple yet effective practices, you can greatly extend the HPLC column life while ensuring reliable, high-quality results in your analyses.</p><h4><strong>Proper Column Handling</strong></h4><p>HPLC columns should be handled with care to prevent physical damage or shock. The pump should not be started at high flow rates; instead, the flow rate should be gradually increased over several minutes. A pump pressure limit should be set to protect the column from over pressuring, as sudden pressure changes can lead to voids, negatively affecting the column’s performance.</p><h4><strong>HPLC Column Conditioning and Equilibration</strong></h4><p>Conditioning is a critical step for preparing a new or stored HPLC column by replacing the storage solvent with the desired mobile phase. Care must be taken to avoid introducing immiscible solvent mixtures into the column. Universally miscible solvents such as <strong>THF (tetrahydrofuran) </strong>or <strong>IPA (isopropyl alcohol) </strong>can be useful for this process when moving from normal phase to reversed phase solvent systems. Care must also be taken to ensure that solvents that may be damaging to a specific stationary phase are avoided.</p><p>For example, if a reversed-phase column experiences <strong>phase collapse </strong>due to 100% aqueous mobile phases, it should be reactivated. This process involves running 100% acetonitrile at a high flow rate and a temperature as high as 60°C. It is essential to ensure no solid buffers precipitate from residual solvents. Depending on the column condition, between <strong>50 and 100 column volumes </strong>are needed for complete reactivation and equilibration, restoring the column’s efficiency for future use.</p><h4><strong>Optimizing Operating Conditions</strong></h4><p>Optimizing operating conditions is paramount to enhancing HPLC column efficiency and prolonging their operational lifespan. A fundamental aspect of this is strict adherence to the manufacturer’s recommended <strong>temperature, pH and pressure parameters</strong>.</p><p>Deviating from these limits, particularly by operating at<strong> elevated temperatures</strong>, can significantly hasten the degradation of the stationary phase and hardware, thereby compromising overall performance. Elevated temperatures can also narrow the pH operating range, exacerbating the risk of column degradation through phenomena such as peak broadening or diminished efficiency.</p><p>Effective <strong>pressure management</strong> is equally crucial. Sudden pressure surges or mechanical shocks can result in bed voiding, leading to poor chromatographic performance, such as split peaks and reduced separation efficiency. Gradual ramping of flow and pressure, implemented each time the column is initiated, mitigates these risks. Many modern HPLC systems are equipped with automated flow-pressure ramping capabilities, ensuring smoother transitions and reducing the potential for column damage.</p><p>In addition, vigilant monitoring of the<strong> mobile phase's pH </strong>is vital to the maintenance of HPLC column integrity. Deviations from the optimal pH range can cause significant harm to the stationary phase. For instance, leads to ligand hydrolysis which leads to a loss of stationary phase functionality and diminished column performance over time. High pH can lead to silica degradation. This weakens the silica structure, causing particle dissolution, void formation, and loss of column efficiency. Maintaining the pH within optimal boundaries is essential for preserving the column’s structural integrity and ensuring consistent chromatographic performance.</p><p>Furthermore, incorporating <strong>inline filters and guard columns</strong> into the system serves as a proactive measure to prevent particulates and harsh sample matrices from damaging the analytical column. These preventive tools significantly enhance operational conditions and safeguard the column from contamination, ultimately contributing to extended HPLC column lifetime and reliable performance.</p><h4><strong>Regular Column Maintenance</strong></h4><p>Effective routine maintenance is paramount to extending the HPLC column lifetime and ensuring the consistent performance of HPLC columns. A critical aspect of this maintenance is the thorough washing of the column after each use to eliminate residual sample components and mobile phase contaminants.</p><p>The cleaning process generally involves performing an isocratic or gradient wash using a solvent system similar to the one previously used on the column but substituting the buffer with HPLC-grade water. This helps effectively remove any residual buffer components from the column. This meticulous cleaning process is vital to preventing the accumulation of impurities that could compromise the stationary phase and lead to decreased efficiency over time.</p><p>Post-cleaning, it is imperative to <strong>end-cap the column</strong> before storage to prevent the stationary phase from drying out, a condition that can negatively impact the column’s future performance. Proper capping or sealing ensures that the column remains in optimal condition, safeguarding its structural integrity and readiness for subsequent analyses.</p><p>Additionally, utilizing an older HPLC system as a dedicated wash station can further streamline maintenance practices, freeing up live systems for active use. Consistently adhering to a rigorous cleaning and storage regimen not only enhances the longevity of HPLC columns but also guarantees the delivery of precise and reliable analytical results.</p><p>For severe contamination or pressure buildup, <strong>backflushing </strong>may be necessary to dislodge tightly bound contaminants. However, backflushing should only be performed when absolutely necessary, as it can stress the column packing material. It is essential to consult the manufacturer’s instructions before attempting this method.</p>

How to Extend the Lifetime of HPLC Columns?

Article

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Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

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SCIEX

<p><strong>With the discussions and initiatives around real-time release testing, we want to look at how this topic could influence what dissolution testing looks like in the future.</strong></p>
<p>While we certainly cannot avoid dissolution testing entirely, reduced testing could be on the horizon. There are many questions to ask, and we will try to give some guidance on this exciting topic. What are the hurdles; who are the early adopters? Are all products and workflows suitable for this new approach? Do you already have experience with the topic? Then please share it with us and the audience.</p>
<blockquote>
<p><strong>Presenter</strong>: Karen Krauel-Göllner, PhD (Product Manager Dissolution, Agilent Technologies, Inc.)</p>
</blockquote>
<blockquote>
<p>Karen Krauel-Göllner is a registered pharmacist and holds a PhD in Pharmacy from the University of Otago, New Zealand. Karen has worked in various roles in the field of pharmaceutical development. For the last 10 years she has been working with Agilent Technologies and currently holds a position as product manager for dissolution systems.</p>
</blockquote>
<blockquote>
<p><strong>Presenter</strong>: Ken Boda (Dissolution Product Specialist, Agilent Technologies, Inc.)</p>
</blockquote>
<blockquote>
<p>Ken joined Varian (now Agilent) in 2005 as an applications engineer and is now a dissolution product specialist. Prior to working at Agilent, he worked in pharma specializing in dissolution testing and method development. As a dissolution product specialist, Ken works with customers in determining the best systems for their needs and optimizing their workflows. He has also helped educate customers on dissolution science through webinars, the Dissolution Discussion Group, LinkedIn, and other channels.</p>
</blockquote>
<blockquote>
<p><strong>Presenter</strong>: Bryan Crist (President, DissoAssist Consulting, Wilmington, NC, USA)</p>
</blockquote>
<blockquote>
<p>Bryan has been the president of DissoAssist consulting based in Wilmington, NC, USA since 2021. He provides consulting, coaching, and training services for dissolution and drug release in the pharmaceutical industry. Bryan is also an active member on various USP Expert Committees.</p>
</blockquote>
<blockquote>
<p>Previously, Bryan was a scientific affairs manager with Agilent Technologies located in Cary, North Carolina, USA. From 1997 to 2021, he focused on providing method and technical application support for dissolution and drug release testing in the pharmaceutical industry as well as working with VanKel, Varian, and eventually Agilent. Prior to 1997, Bryan supervised and managed pharmaceutical laboratories and performed analytical testing with Bristol-Myers Squibb, Merck, AAI, and Abbott Laboratories until he joined the dissolution equipment manufacturer VanKel.</p>
</blockquote>
<blockquote>
<p><strong>Presenter</strong>: Vivian Gray (Founder VA Gray Consulting; Managing Director of Dissolution Technologies)</p>
</blockquote>
<blockquote>
<p>Vivian has spent the last 40+ years involved in all aspects of dissolution testing and evaluating new dissolution technology. At the United States Pharmacopeia, she enjoyed a long career serving first as a bench chemist, supervisor, and lastly as a liaison to various expert USP committees. In 1997, Vivian joined the DuPont-Merck Pharmaceuticals Company Analytical Research and Development Section as the head of the Dissolution Group. In 2002, she formed her own consulting business, V. A. Gray Consulting, Inc., in dissolution testing and related areas. In June 2003, she became managing director of Dissolution Technologies, a peer-reviewed journal dealing specifically with dissolution testing issues.</p>
</blockquote>


Agilent: Applications for Predictive Dissolution Testing

Applications for Predictive Dissolution Testing

We want to look at how Predictive Dissolution could influence what dissolution testing looks like in the future.

<h4><strong>LC-MS/MS fundamentals webinar series 2.0</strong></h4>
<p><strong>Advanced techniques for data acquisition and processing</strong></p>
<p><strong>Elevate your analytical expertise with advanced techniques and workflows</strong></p>
<p>Sharpen your data acquisition and processing skills with our LC-MS/MS 2.0 webinar series. Based on our LC-MS/MS 1.0 webinar series, these sessions will go beyond the fundamentals of LC-MS/MS and introduce ways to advance your analytical methods and data processing workflows.</p>
<p>Every other week, we will explore how to optimize SCIEX OS software with short, 30-minute expert-led presentations.</p>
<h4><strong>This webinar:</strong></h4>
<p>July 30, 2024 11:00 a.m. - 11:30 a.m. CET - <strong>Excel strategies for mass spectrometry data analysis</strong></p>
<p>Take an in-depth look at when and how to use Excel to increase your productivity.</p>
<h4><strong>Other webinars from the series:</strong></h4>
<p>May 7, 2024 11:00 a.m. - 11:30 a.m. CET    - <a href="https://lcms.cz/webinar/3820"><strong>Beyond the fundamentals</strong></a></p>
<p>May 21, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3852"><strong>Advanced MS/MS method building</strong></a></p>
<p>Gain insight into advanced features for maximizing sensitivity in your mass spectrometry analyses.</p>
<p>June 4, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3853"><strong>Mastering chromatography</strong></a></p>
<p>Discover how to optimize your chromatography for even the most challenging compounds while creating and building LC methods.</p>
<p>June 18, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3854"><strong>It&#39;s a TRAP! Getting the most out of your QTRAP system</strong></a></p>
<p>Learn when to utilize QTRAP functionality to create more selective and sensitive methods.</p>
<p>July 2, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3855"><strong>Troubleshooting at the source</strong></a></p>
<p>Acquire the knowledge needed to optimize source parameters and identify and resolve ionization-related problems.</p>
<p>July 16, 2024 11:00 a.m. - 11:30 a.m. CET - <a href="https://lcms.labrulez.com/webinar/3856"><strong>Automating data processing</strong></a></p>
<p>Learn how to automate your data processing with custom flagging and rules for efficient data review in SCIEX OS software.</p>


SCIEX: LC-MS/MS fundamentals webinar series 2.0

Excel strategies for mass spectrometry data analysis

Elevate your analytical expertise with advanced techniques and workflows.

<p><strong>Chlorhexidine is a disinfectant and antiseptic widely used for skin disinfection prior to surgery, and for cleaning wounds or treating oral infections. The current European Pharmacopeia chlorhexidine digluconate monograph has proved problematic. In this webinar the proposed draft monograph is evaluated, considering multiple batches of HPLC columns, and also the impact of system dwell volume on the overall performance and robustness of the monograph method.</strong></p>
<p><strong>Who Should Attend:</strong></p>
<p>Any LC laboratory managers, analysts looking to learn more about Chlorhexidine</p>
<p><strong>Key Learning Points:</strong></p>
<ul>
<li>Find what is it required to achieve system suitability criteria in LC analysis</li>
<li>Learn why batch to batch reproducibility test important in method validation </li>
<li>Understand why and when must gradient delay volume be considered </li>
<li>Catch the importance of choosing the “right” column and “correct” gradient elution for separating a great number of impurities</li>
</ul>
<blockquote>
<p><strong>Presenter:</strong> Dr. Amra Perva (University of Maribor, Faculty of Chemistry and Chemical Engineering)</p>
</blockquote>
<blockquote>
<p>Amra is employed as a research fellow at the Faculty of Chemistry and Chemical Engineering at the University of Maribor (Slovenia).  As the project lead in a GMP certified Contract Research Organization (Group for Separation Analysis) she has over a decade of experience working with pharmaceutical companies in the field of LC and GC method development, validation, stability and release testing for drug substance and drug product.</p>
</blockquote>


Phenomenex: Batch Reproducibility and Effect of Gradient Delay Volume on Separation of Impurities of Chlorhexidine Digluconate

Batch Reproducibility and Effect of Gradient Delay Volume on Separation of Impurities of Chlorhexidine Digluconate

Separation of Impurities of Chlorhexidine Digluconate

<p><strong>The combination of PFAS testing, trace-level requirements, and complex mass spec applications can be intimidating. Here, we show you how you can achieve data stability in a tough matrix over thousands of injections, how to maximize software features, and how to ensure you’re fully equipped to address any future challenges related to PFAS testing.</strong></p>
<p><strong>By attending this webinar, you will learn:</strong></p>
<ul>
<li>How technologies like Mass Guard can help you with challenging matrices and maintain sensitivity in over 7,000 injections. </li>
<li>How you can maximize the interplay between hardware and software to take advantage of instrumentation.</li>
</ul>
<p><strong>Who should attend?</strong></p>
<ul>
<li>Everyone who works in the PFAS testing field</li>
</ul>
<p><strong>What you need to know:</strong></p>
<ul>
<li>Date: 31 July, 2024</li>
<li>Broadcast #1: 31 July - 10 am BST (London) / 11 am CEST (Paris/Berlin) / 2:30 pm IST (New Delhi) / 5 pm SGT (Singapore)</li>
<li>Broadcast #2: 31 July - 10 am PDT (Los Angeles) / 12 pm CDT (Chicago) / 1 pm EDT (New York)</li>
<li>Duration: Approximately 60 minutes</li>
</ul>
<blockquote>
<p><strong>Presenter:</strong> Craig Butt (Senior Manager, Applied Markets, SCIEX)</p>
</blockquote>
<blockquote>
<p>Craig obtained his PhD in environmental chemistry at the University of Toronto, under the co-supervision of Dr. Scott Mabury and Dr. Derek Muir (Environment Canada), where he investigated the fate of PFAS in biological systems. Craig was then an NSERC postdoctoral research fellow and research scientist at Duke University, under the guidance of Dr. Heather Stapleton. Among other interesting topics, Craig&#39;s postdoctoral research involved measuring human PFAS exposure in serum, hand wipes, and wristbands. In his 20 years of mass spectrometry experience, Craig has published 48 peer-reviewed manuscripts, many of which are on PFAS, are globally recognized, and are highly cited. Within SCIEX, Craig is the applications lead for all things PFAS and has contributed to a variety of PFAS-specific applications, including EPA Methods 537.1 and 533.</p>
</blockquote>


Separation Science: PFAS Analysis in Food: A Robustness Study in Sensitivity and Stability

PFAS Analysis in Food: A Robustness Study in Sensitivity and Stability

Learn how cutting-edge mass spec technology can co-exist with stability and robustness.  It doesn’t have to be a compromise.

PFAS Analysis in Food: A Robustness Study

<p><strong>Co-solvation (a direct inject method) is ideal for testing analytes as they transition from non-target to target PFAS compounds. Combustion methods are good for total analyses, but they do not have the ability to speciate.</strong></p>
<p>Accurate mass instrumentation (e.g., QTOF) is great for compound identification, but it is not ideal for quantitation. A direct inject method eliminates the need for choosing an SPE (solid phase extraction) cartridge, which is beneficial since SPE is a layer of selectivity that presents an additional hurdle for new analytes. Direct injection bypasses SPE obstacles, which streamlines and optimizes method development, allowing a quicker and more dependable response to rapidly evolving PFAS testing needs. This presentation explores the unique advantages of direct inject methods and helps transition from non-target compounds to quantitative actionable results.</p>
<blockquote>
<p><strong>Presenter:</strong> Maya Murshak (CEO and Technical Director, Merit Laboratories)</p>
</blockquote>
<blockquote>
<p>Maya is the CEO and Technical Director for Merit Laboratories. She currently oversees all of the laboratory functions. Maya continues to work closely with laboratory certification, accreditation, and project coordination. She has over 37 years of practical laboratory experience based on her extensive analytical work with both chromatography and mass spec systems. Maya is a Chemical Engineer, holding both B.S. and M.S. degrees from Michigan State University. Go Green!</p>
</blockquote>


Agilent: Benefits of Co-Solvation Methods for Non-target PFAS Analyte

Benefits of Co-Solvation Methods for Non-target PFAS Analyte

This presentation explores the unique advantages of direct inject methods and helps transition from non-target compounds to quantitative actionable results.

Co-Solvation Methods for Non-target PFAS Analyte

<p><strong>Advance your per- and polyfluoroalkyl substances (PFAS) research and testing with automated solutions designed for efficiency and precision.</strong></p>
<h5>Key Topics:</h5>
<ul>
<li><strong>PFAS Fundamentals: Learn about the chemistry and significance of PFAS.</strong></li>
<li><strong>Sample Preparation Challenges: Understand current hurdles, regulations and best practices in PFAS extraction and purification.</strong></li>
<li><strong>Automated LC-MS Workflows: Get an overview on automated workflows and see how PAL System integrates with LC-MS to optimize sample preparation and injection.</strong></li>
<li><strong>Deep Dive: Explore online SPE for PFAS analysis.</strong></li>
<li>Q&amp;A: Engage with our scientific experts and get your questions answered.</li>
</ul>
<p>Register now to explore the cutting edge of automated PFAS analysis and fully utilize your PAL System.</p>
<p>Please be advised that this webinar is being recorded and available for the content hub at palsystem.com. While your microphone and camera will be disabled, your name and any questions you ask in the chat feature will be visible to other participants. By participating in the webinar, you consent to this recording.</p>
<blockquote>
<p><strong>Presenter:</strong> Tiantian Li (Product ManagerCTC Analytics AG)</p>
</blockquote>
<blockquote>
<p>Dr. Tiantian Li is a Product Manager at CTC Analytics specializing in LC-MS workflows, focusing on PFAS workflow solutions. She holds a PhD in chemistry from the Fraunhofer LBF Institute in Darmstadt, Germany. Additionally, Tiantian has 10 years of experience at Agilent, working in R&amp;D and as a Product Manager for LC Supplies.</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Hagen Gegner (Content Online Marketing SpecialistCTC Analytics AG)</p>
</blockquote>
<blockquote>
<p>Dr. Hagen M. Gegner is a content creator and metabolomics specialist, he focuses on PAL System automation and workflow solutions. Hagen earned his Ph.D. in Marine Science from KAUST, where his research focused on metabolomics in corals. Following his Ph.D., he pursued a postdoctoral fellowship at the University of Heidelberg, investigating cancer biomarkers.</p>
</blockquote>


CTC Analytics: Advancing PFAS Analysis: Robotic Automation and Streamlined LC-MS Workflows

Advancing PFAS Analysis: Robotic Automation and Streamlined LC-MS Workflows

This webinar showcases the latest advancements in LC-MS workflows and robotic automation.

Advancing PFAS Analysis: Robotic Automation and LC-MS

<p><strong>Explore the latest knowledge on the safety, authenticity and quality of food and beverages, as well as the technology that supports the critical work done to ensure the integrity of the food supply chain.</strong></p>
<h5>This online symposium will explore:</h5>
<ul>
<li><strong>Untargeted analysis techniques used to ensure food authenticity</strong></li>
<li><strong>Sample preparation techniques for food applications</strong></li>
<li><strong>Use of thermal infrared imaging for salmonella detection</strong></li>
<li><strong>Elemental analysis for food and beverage testing</strong></li>
<li><strong>Miniaturized food analysis devices</strong></li>
<li><strong>Sustainable lab consumables for food analysis</strong></li>
<li><strong>Heavy metals in processed baby food</strong></li>
<li><strong>Residual analysis using GC/MS</strong></li>
</ul>
<h3><strong>Day 1 – July 24</strong></h3>
<h5><strong>16:00 – 17:00 BST How to Use and Interpret Untargeted Testing for Food Authenticity</strong></h5>
<ul>
<li>John Points, Kate Kemsley, PhD and Catherine Frankis, PhD (Food Authenticity Network)</li>
</ul>
<h5><strong>17:00 – 17:10 BST</strong> Networking Break</h5>
<h5><strong>17:10 – 17:55 BST Beyond All Limits: Elevating the Standards of Residual Analysis with Triple Quadrupole GC/MS</strong></h5>
<ul>
<li>Joel Ferrer and Anastasia Andrianova, PhD (Agilent)</li>
</ul>
<h5><strong>17:55 – 18:00 BST</strong> Networking Break</h5>
<h5><strong>18:00 – 18:20 BST Elemental Analysis Trends and Advances in Food and Beverage Testing</strong></h5>
<ul>
<li>Nikolay Kovachev, PhD (Agilent)</li>
</ul>
<h5><strong>18:20 – 18:30 BST</strong> Networking Break</h5>
<h5><strong>18:30 – 19:10 BST The Use of Thermal Infrared Cameras for Pathogen Detection (Salmonella) on Tomato Surfaces</strong></h5>
<ul>
<li>Andy Moreno, PhD (AME Certified PCR AI Laboratories)</li>
</ul>
<h5><strong>19:10 – 19:20 BST</strong> Networking Break</h5>
<h5><strong>19:20 – 19:40 BST About the Use of Micro-SPE for an Automated and Green Sample Preparation</strong></h5>
<ul>
<li>Hans-Joachim Hübschmann, PhD (PAL System)</li>
</ul>
<h5><strong>19:40 – 19:50 BST</strong> Networking Break</h5>
<h5><strong>19:50 – 20:30 BST Driving Behaviors for Food and Beverage Breakthroughs</strong></h5>
<ul>
<li>Trevor Morones, PhD (Control Point)</li>
</ul>
<h5><strong>20:30 BST</strong> End of Day 1</h5>


Technology Networks: Advances in Food and Beverage Testing 2024

Advances in Food and Beverage Testing 2024 (Day 1)

Explore the latest knowledge on the safety, authenticity and quality of food and beverages.

<p><strong>Explore the latest knowledge on the safety, authenticity and quality of food and beverages, as well as the technology that supports the critical work done to ensure the integrity of the food supply chain.</strong></p>
<h5>This online symposium will explore:</h5>
<ul>
<li><strong>Untargeted analysis techniques used to ensure food authenticity</strong></li>
<li><strong>Sample preparation techniques for food applications</strong></li>
<li><strong>Use of thermal infrared imaging for salmonella detection</strong></li>
<li><strong>Elemental analysis for food and beverage testing</strong></li>
<li><strong>Miniaturized food analysis devices</strong></li>
<li><strong>Sustainable lab consumables for food analysis</strong></li>
<li><strong>Heavy metals in processed baby food</strong></li>
<li><strong>Residual analysis using GC/MS</strong></li>
</ul>
<h3><strong>Day 2 – July 25</strong></h3>
<h5><strong>16:00 – 16:40 BST Miniaturization of Analytics: A Better Control from Farm to Fork</strong></h5>
<ul>
<li>Marta Prado, PhD (University of Santiago de Compostela)</li>
</ul>
<h5><strong>16:40 – 16:50 BST</strong> Networking Break</h5>
<h5><strong>16:50 – 17:10 BST Unleashing the Power of AI powered LIMS in Food and Beverage Testing</strong></h5>
<ul>
<li>Daniel Call (LabVantage)</li>
</ul>
<h5><strong>17:10 – 17:20 BST</strong> Networking Break</h5>
<h5><strong>17:20 – 18:00 BST Heavy Metals in Processed Baby Food: Could Regulators be Doing More to Ensure Consumer Safety?</strong></h5>
<ul>
<li>Robert Thomas (Scientific Solutions)</li>
</ul>
<h5><strong>18:00 – 18:10 BST</strong> Networking Break</h5>
<h5><strong>18:10 – 18:30 BST Sustainable Lab Consumables without Compromising Performance</strong></h5>
<ul>
<li>Jack Gikonyo (Eppendorf Americas)</li>
</ul>
<h5><strong>18:30 – 18:40 BST</strong> Networking Break</h5>
<h5><strong>18:40 – 19:20 BST Applications of NIRS and NIR Imaging in Food</strong></h5>
<ul>
<li>Vincent Baeten, PhD (Walloon Agricultural Research Centre)</li>
</ul>
<h5><strong>19:20 BST</strong> Event Close</h5>


Advances in Food and Beverage Testing 2024 (Day 2)

<p><strong>Rebroadcast of the Live from the Lab: Solutions for Multi-Omics Research from June 13, 2024</strong></p>
<p><strong>The new Stellar MS - Instrumentation that scales analytical throughput reliably and practically</strong></p>
<p>How can you bridge the gap between discovery and the clinical research? </p>
<p>With the new Thermo Scientific Stellar MS, it’s now easier than ever to go from discovery to validation with unrivaled quantitation at scale.</p>
<p><strong>Key learning points</strong></p>
<ul>
<li>Meet the most advanced ion trap platform, the new Stellar MS system with acquisition rates of 100Hz+, MS3, and HCD/Resonance CID.</li>
<li>Hear how PRM Conductor Software helps bridge discovery to targeted gap, eliminates/reduces scripting+Microsoft® Excel, and automates refinement/method creation.</li>
<li>Learn how intelligent acquisition provides adaptive RT for higher throughput and robust operation, and dynamic AGC for best quantitation.</li>
</ul>
<p>Can&#39;t attend the rebroadcast? No problem! Register anyway and you will automatically receive the link to the recording. </p>
<blockquote>
<p><strong>Presenter:</strong> Hamish Stewart (Senior Staff Scientist, Thermo Fisher Scientific)</p>
</blockquote>
<blockquote>
<p>Hamish Stewart is a Senior Staff Scientist at Thermo Fisher Scientific Bremen. He is the lead scientist for the Orbitrap Astral and a developer of Orbitrap instrumentation, responsible for research on future commercial mass spectrometers, novel related concepts and technologies.</p>
</blockquote>
<blockquote>
<p>Previously, he obtained his PhD in Physical Chemistry from the University of Nottingham and then worked for Shimadzu Research Laboratory (Europe) Ltd.</p>
</blockquote>
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<p>He is the holder of 65 patents and is the winner of The George N Hatsopoulos Technical Innovation Award.</p>
</blockquote>


The new Stellar MS - Instrumentation that scales analytical throughput reliably and practically

With the new Thermo Scientific Stellar MS, it’s now easier than ever to go from discovery to validation with unrivaled quantitation at scale.

The new Thermo Scientific Stellar MS

<p><strong>At ASMS 2024, Bruker&#39;s Life Science division unveiled a range of cutting-edge products, including the timsTOF Ultra 2 with significant increases in sensitivity for deep proteome analysis. Additionally, the new neofleX™ MALDI-TOF benchtop system was showcased, offering improved sensitivity and accuracy for proteomics and metabolomics research with automated workflow using SCiLS™ autopilot. The new OmniScape™ and Bruker ProteoScape™ software solutions are being highlighted for their advanced data analysis capabilities. OmniScape improves the speed and quality of annotations for top-down sequencing, while Bruker ProteoScape™ now includes the Spectronaut® core module for directDIA+ workflows. Additionally, the Bruker ProteoScape™ package includes GlycoScape™, a real-time glycopeptide analysis workflow.</strong></p>
<p><strong>Key Learnings:</strong></p>
<ul>
<li>timsTOF Ultra 2 for unmatched robustness, unparalleled duty cycle, and single-cell sensitivity</li>
<li>Analytical merits, and applications of the new benchtop MALDI-TOF neofleX™</li>
<li>Multiomics capabilities of MALDI Imaging</li>
<li>OmniScape™ improves the speed and quality of annotations for top-down spectra</li>
<li>Bruker ProteoScape™ Package includes the Spectronaut core module for directDIA+ workflows</li>
<li>GlycoScape™ - a real-time glycopeptide analysis workflow - will be included in the Bruker ProteoScape™ package  </li>
<li>MetaboScape® - All-in-one software solution for compound identification in small molecule research</li>
</ul>
<blockquote>
<p><strong>Presenter:</strong> Adam Rainczuk, Application Specialist</p>
</blockquote>
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<p><strong>Presenter:</strong> Tosapol (Paul) Anukunwithaya, Application Specialist</p>
</blockquote>
<blockquote>
<p><strong>Presenter:</strong> Wen Donq (Gaelin) Looi, Application Specialist</p>
</blockquote>


Bruker: Advancing Multiomics, Biopharma, and MS Imaging - Latest MS Technologies 

Advancing Multiomics, Biopharma, and MS Imaging - Latest MS Technologies 

Bruker unveiled a range of cutting-edge products, including the timsTOF Ultra 2 for deep proteome analysis.