ChromSolutions Ltd, a leading provider of analytical instrumentation solutions and Wiley, a global leader in authoritative content and research intelligence, today announced an agreement to distribute Wiley’s KnowItAll spectral software and databases and thus expand access to advanced untargeted analysis technologies for scientists working in chromatography and spectroscopy.By combining ChromSolutions’ hardware expertise with Wiley’s world-class software capabilities, customers will be empowered with more comprehensive and user-friendly tools for untargeted analysis, enhancing productivity and improving data confidence in complex sample matrices.“This collaboration is a natural fit,” said Kevin Fernandes, Managing Director of Strategic Partnerships at ChromSolutions Ltd. “Our customers are looking for deeper, faster, and more accurate insights from their data. Wiley’s KnowItAll software is a perfect complement to our instruments, particularly for laboratories dealing with unknowns in complex samples.”“We are excited to bring our data analysis tools to a broader community of scientists through ChromSolutions,” said Graeme Whitley, Director, Data Science Solutions at Wiley. “Together, we’re lowering the barrier to high-performance untargeted compound identification in critical scientific fields.”Wiley's KnowItAll provides a unified manufacturer-neutral software solution to identify, analyze, and manage analytical data across multiple techniques (IR, GC-MS, LC-MS, NMR, Raman, UV-Vis). Powered by Wiley's comprehensive, high-quality spectral reference libraries and advanced search algorithms, KnowItAll delivers fast, reliable spectral analysis that streamlines laboratory workflows and drives actionable results for confident decision making.This agreement is expected to roll out in the fall with pilot program opportunities available for early adopters.<h4>About Chromsolutions</h4>ChromSolutions was formed in 2004 and provides advanced analytical instrumentation, method development, and support services with a focus on Gas Chromatography (GC), GC/MS, and custom turnkey systems. Working in collaboration with various partners and collaborators, ChromSolutions delivers tailored solutions that combine hardware, software, libraries, and expertise to meet the needs of laboratories across multiple sectors. Through its ChromTelemetry™ remote support platform, ChromSolutions offers secure, expert assistance in training, troubleshooting, data analysis, and application development—helping clients maximize uptime, extend system capabilities, and reduce environmental impact.With over 120 years of collective experience and guided by its principle of “Knowledge When You Need It,” ChromSolutions enables small to medium enterprises, contract laboratories, and research organizations to achieve reliable, high-quality results.<h4>About <a target="_blank" rel="noopener noreferrer" href="https://www.wiley.com/en-ie/">Wiley</a></h4>Wiley (NYSE: WLY) is a global leader in authoritative content and research intelligence for the advancement of scientific discovery, innovation, and learning. With more than 200 years at the center of the scholarly ecosystem, Wiley combines trusted publishing heritage with AI-powered platforms to transform how knowledge is discovered, accessed, and applied. From individual researchers and students to Fortune 500 R&amp;D teams, Wiley enables the transformation of scientific breakthroughs into real-world impact. From knowledge to impact—Wiley is redefining what's possible in science and learning.&nbsp;

ChromSolutions Ltd Advances Untargeted Compound Analysis for its Customers with Wiley's KnowItAll Software

Biopharmaceutical pipelines are expanding rapidly, with increasingly diverse therapeutic modalities such as antibody-drug conjugates (ADCs), oligonucleotides, PROTACs, and RNA-based therapies. Each of these presents unique analytical challenges, from structural heterogeneity to low-abundance impurities, that require highly versatile and sensitive instrumentation.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Scaling_Up_Biopharmaceutical_Characterization_with_the_Orbitrap_Ascend_Bio_Pharma_Tribrid_Mass_Spectrometer_4596c67b6c.jpg" alt="Thermo Fisher Scientific: Scaling Up Biopharmaceutical Characterization with the Orbitrap Ascend BioPharma Tribrid Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Scaling_Up_Biopharmaceutical_Characterization_with_the_Orbitrap_Ascend_Bio_Pharma_Tribrid_Mass_Spectrometer_4596c67b6c.jpg 245w," sizes="100vw" width="1024" height="512">The <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/748">Thermo Scientific Orbitrap Ascend BioPharma Tribrid Mass Spectrometer</a> was developed to meet these challenges head-on. Designed with a new dual ion routing multipole architecture, extended mass range detection, and integrated ease-of-use features, it enables comprehensive characterization of today’s most complex therapeutic molecules.<h3>Scaling up insight for biopharma</h3>The Orbitrap Ascend BioPharma MS introduces several key innovations that directly address bottlenecks in drug characterization:<ul><li>Native MS with extended mass range: Quadrupole isolation up to m/z 8,000 and Orbitrap detection up to m/z 16,000 allow detailed characterization of intact protein complexes and biotherapeutics in their native states.</li><li>Proton Transfer Charge Reduction (PTCR): Simplifies highly heterogeneous spectra, enabling confident identification of proteoforms.</li><li>Orthogonal fragmentation options (HCD, CID, ETD, EThcD, UVPD): Deliver near-complete sequence coverage and precise localization of post-translational modifications (PTMs) and conjugation sites.</li><li>Ultra-high-field Orbitrap analyzer: Provides &gt;480K resolution at FWHM and acquisition rates up to 45 Hz, supporting both depth and throughput.</li><li>Auto-ready ion source: Enables automated, remote, and schedulable calibration, maintaining performance and consistency without interrupting experimental workflows.</li></ul><h3>Applications across the biopharma landscape</h3><ul><li>Antibody-Drug Conjugates (ADCs) Middle-down analysis with PTCR and orthogonal fragmentation provides accurate drug-to-antibody ratio (DAR) determination and unambiguous localization of conjugation sites. Intact and fragmented analyses can be seamlessly combined in a single workflow.</li><li>Host Cell Protein (HCP) monitoring The Orbitrap Ascend BioPharma MS detects trace HCPs at concentrations below 1 ppm at analytical flow rates, overcoming dynamic range challenges and supporting regulatory expectations for impurity profiling.</li><li>PTM mapping Enhanced sensitivity enables the confident detection of low-abundance modifications (&lt;1%), including challenging events such as deamidation, with 100% sequence coverage of both heavy and light antibody chains.</li><li>Oligonucleotide and RNA therapeutics Low-q CID and UVPD fragmentation deliver nearly complete sequence coverage of intact oligonucleotides and sgRNAs, supporting the growing importance of gene and RNA-based therapies.</li><li>Top-down proteomics The system’s versatility supports the direct characterization of intact proteoforms, providing clarity in structural biology and biopharmaceutical analysis.</li></ul><h3>Researcher perspective</h3>According to Prof. Luca Fornelli, the University of Oklahoma:“The Orbitrap Ascend BioPharma mass spectrometer combines two fundamental features that make it perfect for characterizing intact biopharmaceuticals. Multiple ion activation types are complemented by PTCR to simplify complex mass spectra and facilitate their interpretation. And the Native MS option increases the Orbitrap m/z range up to m/z 16,000. Together they enable researchers to perform sophisticated ion manipulations and analyze the most diverse molecules.”<h3>Enabling confidence in therapeutic development</h3>By scaling up analytical depth, throughput, and reproducibility, the Orbitrap Ascend BioPharma Tribrid Mass Spectrometer provides scientists with a powerful platform for characterizing complex therapeutics. Whether identifying trace-level impurities, localizing conjugation sites, or sequencing RNA molecules, Orbitrap Ascend MS delivers the clarity and confidence required to accelerate development timelines and meet regulatory expectations.<blockquote>For Research Use Only. Not for use in diagnostic procedures.</blockquote><blockquote><ul><li>Learn more about <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/748">Orbitrap Ascend BioPharma Tribrid MS</a></li><li>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#OrbitrapAscend #Biopharma #PTM #Oligonucleotides</li></ul></blockquote>

Scaling Up Biopharmaceutical Characterization with the Orbitrap Ascend BioPharma Tribrid Mass Spectrometer

Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 29th December 2025? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you application notes by Agilent Technologies and Shimadzu!<h3>1. Agilent Technologies: Fatty Acid Methyl Ester Analysis Using the Agilent 8850 GC System</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_fame_analysis_8850_gc_5994_8743en_agilent_2bed33b70d.pdf">Full PDF for download</a></li></ul>Fatty acids are components of fat and are an essential component of a healthy diet. They are found in a variety of foods, including oily fish, nuts, seeds, and vegetable oils. Fatty acids can be categorized as saturated fat, monounsaturated fat, polyunsaturated fat (including omega-3 and omega-6 fatty acids), and trans fat. Unsaturated fatty acids play a beneficial role in maintaining heart and vascular performance. However, artificial trans fatty acids, found in processed foods, should be strictly limited. The measurement of fatty acids in food plays an important role in:<ul><li>Nutritional assessment: Analyzing the omega-3/omega-6 ratio for dietary nutrient balance&nbsp;</li><li>Safety regulation: Identifying health risks such as trans fatty acids&nbsp;</li><li>Quality control: Detecting oil adulteration and process&nbsp;defects&nbsp;</li><li>R&amp;D support: Providing data support for the development of functional foods&nbsp;</li></ul>Techniques available for fatty acid determination in food include gas chromatography, liquid chromatography, and spectroscopic techniques. Each technique has its own advantages, disadvantages, and applicable scenarios. For example, liquid chromatography is suitable for analyzing heat-labile fatty acids, but it suffers from low resolution. Fluorescence spectroscopy is simple to operate but susceptible to matrix effects and poor specificity. Gas chromatography is the most used technique for fatty acid measurement. Fatty acids in food primarily exist in the form of triglycerides. Before analysis, triglycerides must be extracted, saponified, and methylated to the corresponding FAMEs. FAMEs are less polar and more volatile than fatty acids, making them suitable for analysis on gas chromatography platforms. Polar columns, such as those with polyethylene glycol and cyanopropyl siloxane stationary phases, are primarily used for the FAMEs analysis. Polyethylene glycol stationary phases are good at analyzing simple fatty acid mixtures and are not suitable for the analysis of cis-trans isomers. A column coated with high‑content cyanopropyl phase is recommended in different analytical methods for FAMEs analysis. However, an analysis based on this phase type usually takes more than 70 minutes to finish, and the retention time (RT) stability is not very good. The Agilent J&amp;W DB-FastFAME column features a modified cyanopropyl phase to accelerate the analysis and improve&nbsp;repeatability.&nbsp;Agilent offers DB-FastFAME columns in different dimensions; the 20-meter and 30-meter sizes can help improve the analysis speed for 37 representative FAMEs in food. Previous work demonstrated the analysis speed improvement using the conventional oven ramp rate on the two columns.1 With the launch of the Agilent 8850 GC, rapid temperature programming can be achieved in an air bath oven. This application note demonstrates the fast analysis of 37 FAMEs using nitrogen (N2 ) and helium (He) carrier gases on the 8850&nbsp;GC. Meanwhile, more complex FAME mixtures including 37&nbsp;FAMEs and 15 trans FAMEs were analyzed on a 90-meter DB-FastFAME column and a 100-meter Agilent J&amp;W HP-88 column to demonstrate the 8850 GC performance in cis/trans FAMEs and position isomers analysis.<h4>Experimental</h4><h5>Instrumentation&nbsp;</h5>An <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8850+GC">8850 GC system </a>equipped with a split/splitless inlet and a flame ionization detector (FID) was used for the analysis. An <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=7650A">Agilent 7650A automatic liquid sampler (ALS)</a> (part&nbsp;number&nbsp;G4567A) was applied for sample injection.&nbsp;The methods performed on the four analytical columns using He and N2 carrier gases are listed in Table 1. The settings on inlet and detector temperatures are the same. The column head pressure and the oven temperature program were optimized based on the column type and carrier gas. Data were acquired and processed using <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=OpenLab+CDS">Agilent OpenLab CDS</a> 2.8. The list of consumables used is shown in Table 2.<h4>Results and discussion&nbsp;</h4><h5>Fast analysis of 37 fatty acid methyl esters on short&nbsp;columns&nbsp;</h5>The 37 FAMEs mimic the fatty acid composition of many food samples, including most of the important saturated, monounsaturated, and polyunsaturated FAMEs. They are well‑established and widely accepted reference materials.&nbsp;A 20 m × 0.18 mm&nbsp;id, 0.2&nbsp;µm DB-FastFAME&nbsp;column and a 30&nbsp;m × 0.25 mm&nbsp;id, 0.25 µm DB-FastFAME&nbsp;column were used to demonstrate the high-speed analysis of 37 FAMEs on the 8850 GC. The oven ramp program and column flow rate were based on previous work and further optimized for the 8850 GC. Both He and N2 carrier gas-based methods were developed considering the increasing alternative carrier gas need and lab operation habits in different regions.&nbsp;The GC-FID chromatograms obtained on the two columns using different carrier gases are shown in Figures 1A, 1B, 2A, and 2B. All compounds were well resolved in the He methods. Three compound pairs that cannot be baseline-separated are shown in black squares. Among them, the peaks of c22:2n6 and c23:0 had the lowest resolution of 1.27 and 1.31 on the 20-meter and 30-meter columns, respectively, using the He method. The AOAC International Method 996.062 requires separating the FAME pair of adjacent peaks of C18:3 and C20:1 and the FAME trio of adjacent peaks of C22:1, C20:3, and C20:4 with a resolution of 1.0 or greater. This requirement is mainly recommended for high-content cyanopropyl 4 stationary phases. The six probe FAMEs eluted in different orders on the DB-FastFAME column, as marked by the yellow squares in the chromatogram. Their separation exceeded the resolution requirement easily due to the DB-FastFAME column's unique selectivity. The analysis times of the He methods were less than 7 minutes and 10 minutes on the two columns. The analysis speed was five to eight times faster than that of conventional methods.<h4>Conclusion&nbsp;</h4>A high-speed FAMEs analysis was achieved on an Agilent&nbsp;8850 GC system with excellent repeatability when running the FAMEs standards on specially engineered 20-meter and 30-meter Agilent J&amp;W DB-FastFAME columns under optimized oven programs. The analysis time is less than 10&nbsp;minutes using He carrier gas and less than 15&nbsp;minutes using N2 carrier gas, which is five to eight times faster than the conventional method. Peak resolutions obtained by the fast methods met the AOAC 996.06 standard requirements. The methods can help improve lab productivity significantly for routine analysis of 37 FAMEs.&nbsp;The analysis of 52 FAMEs on 90-meter DB-FastFAME and 100-meter Agilent J&amp;W HP-88 columns demonstrated that the 8850 GC can deliver performance equivalent to the Agilent 8890 GC system when analyzing complex fatty acids—including cis/trans fatty acids and positional isomers— in terms of resolution, area repeatability (&lt; 2.5%), and RT&nbsp;precision (&lt; 0.04%).<h3>2. Shimadzu: Quantification of 8 Disinfection Byproducts from Water by Liquid-Liquid Extraction and Gas Chromatography-MassSpectrometry</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_07_2507_en_52b8f30f0c.pdf">Full PDF for download</a></li></ul>Disinfectants such as chlorine and chloramine are widely used to eliminate microorganisms in water. However, these disinfectants react with naturally occurring chemical constituents, such as amino acids and other labile organic chemicals, forming a range of disinfection byproducts (DBPs). Chronic exposure to DBPs elevates the risk of developing cancer, liver damage, and decreased nervous system activity. Hence, accurate detection and quantification of DBPs in water is crucial.&nbsp;Although official recommended method for measuring DBPs is based on GC/ECD, GC/MS offers significant advantages in terms of simultaneous quantification and identification of both known and unknown compounds in a single analysis, providing comprehensive data on complex water samples. Unlike ECD, which has a limited dynamic range and can only detect electroactive compounds, MS offers a broader dynamic range, allowing the detection of analytes at varying concentrations. Additionally, GC/MS provides superior sensitivity, specificity, and structural information, making it the ideal method for detailed, high-precision analysis of disinfection byproducts and other water contaminants.<h4>2.2. Analytical Conditions</h4><h5>Preparation of instrument and analysis:</h5>The analytical method was established, and the instrument parameters are detailed in Table 1. Prior to the analysis, both the instrument and the column were conditioned. The “HighSensitivity” autotune mode of the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=GCMS-QP2020+NX">GCMS-QP2020 NX</a> was used for the analysis. A standard solution containing 500 ppb of the target analytes, surrogate, and internal standard was injected using the MS fullscan mode to determine the retention times.The peaks corresponding to the target compounds, internal standard, and surrogate were identified using the NIST GC/MS library. Quantifier and qualifier ions for each analyte were selected, and a compound table was created accordingly and the same was used to develop a Scan/SIM method using the “Creation of Automatic Scan/SIM Table” (COAST) wizard within the GCMSsolutionTM software. The ultra-fast scanning capability (20,000 u/s) of the GCMS-QP2020 NX enables simultaneous acquisition of Scan and SIM events without compromising data quality.&nbsp;The newly created Scan/SIM method was used for the quantification and reporting of analytical data. Calibration standards were analyzed. The data and the calibration curve, using the internal standard method, were processed using LabSolutions InsightTM software which enables the analysis of large numbers of data simultaneously. Following this, both the unspiked and spiked (5 ppb) samples were analyzed and quantified.<h4>3. Result and Discussion</h4>A 6-point calibration curve was created for all target analytes. A good linear response, with correlation coefficients (r²) greater than 0.99, and accuracy within 80-120% was observed for all analytes. A signal-to-noise ratio (S/N) ≥ 10 was observed for all analytes at 5 ppb standard. The results are shown in Table 2.<h4>4. Conclusion</h4><ul><li>A highly sensitive GC/MS method was developed for 8 halogenated DBPs using Shimadzu GCMS-QP2020 NX following USEPA 551.1 sample preparation protocol.&nbsp;</li><li>Excellent linearity results and recovery results at 5.0 ppb concentration for all the analytes demonstrate that the analytical workflow is suitable for analyzing the listed DBPs in tap water using GC/MS technique at a low concentration level.</li></ul>

News from LabRulezGCMS Library - Week 53, 2025

News from LabRulezLCMS Library - Week 53, 2025

Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 29th December 2025? Check out new documents from the field of spectroscopy/spectrometry and related techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">LabRulezLCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> libraries.</blockquote>This week we bring you application notes by LECO, Metrohm and Shimadzu!<h3>1. LECO: Determination of Nitrogen/Protein in Cheese</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/FP_928_NITROGEN_PROTEIN_CHEESE_203_821_673_db228174b4.pdf">Full PDF for download</a></li></ul>Protein is one of the most significant nutrient components in cheese. The accurate and precise determination of protein not only plays a role in the characterization of the nutritional value of cheese but is also key in determining the economic value of different cheeses. A rapid and precise method for the determination of total protein in cheese provides a vital quality and process control procedure.&nbsp;Protein in cheese is most commonly calculated using the measured total Nitrogen content in the sample and a multiplier or protein conversion factor (typically 6.38). Protein conversion factors vary depending on the sample matrix. Nitrogen determination in organic materials is performed using either a classical wet chemical method (Kjeldahl), or a combustion method (Dumas). The Kjeldahl method involves sample digestion, distillation, and ammonia determination typically by titration. This method involves time-consuming sample preparation and the use of hazardous materials. The LECO FP928 is a Nitrogen determinator that utilizes an automated combustion (Dumas) method and provides accurate and precise results in approximately five minutes. This eliminates involved sample preparation and the use of hazardous materials resulting in a rapid, cost-effective method for the quality control of cheese production.&nbsp;<h4>Instrument Model and Configuration&nbsp;</h4>The <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?manufacturerItems=25&amp;search=FP928">FP928</a> is a macro combustion Nitrogen/Protein determinator that utilizes a pure Oxygen environment in a high-temperature horizontal ceramic combustion furnace, utilizing ceramic boats designed to handle macro sample masses (~1.0 g). A thermoelectric cooler removes moisture from the combustion gases before they are collected in a ballast. The gases equilibrate and mix 3 in the ballast before a representative aliquot (3 cm or 3 10 cm volume) of the gas is extracted and introduced into a flowing stream of inert carrier gas (Helium or Argon) for analysis. The aliquot of gas is carried through a heated reduction tube, filled with Copper, to convert Nitrogen Oxide combustion gas species (NO2) to Nitrogen (Nx). The aliquot gas is then carried to a thermal conductivity cell (TC) for the detection of Nitrogen (N2). Thermal conductivity detectors work by detecting changes in the thermal conductivity of the analyte gas compared to a reference/carrier gas. The greater the difference between the thermal conductivity of the carrier gas and the analyte gas, the greater the sensitivity of the detector. The FP928 supports either the use of Helium or Argon as the instrument's carrier gas. When used as a carrier gas, Helium provides the highest sensitivity, and the best performance at the lower limit of the Nitrogen range. The thermal conductivity difference between Argon and Nitrogen is not as great as the thermal conductivity difference between Helium and Nitrogen; therefore, the detector is inherently less sensitive when using Argon as a carrier gas.<h4>Analysis Considerations&nbsp;</h4>The combustion of cheese samples with a high-fat content can result in some degree of sooting. The primary filter tube (glass and steel wool) should be monitored for signs of sooting. If soot is observed in the glass and steel wool within the primary filter tube, reduce the sample mass to prevent this soot build-up, and change the glass and steel wool as necessary. The combustion of cheese samples can also result in the formation of salts; therefore, it is important to monitor the primary filter tube for signs of excessive corrosion of the steel wool and change it as necessary (approximately every 50 cheese samples). In addition, the autoloader arm should be inspected and cleaned on a regular basis when analyzing cheese products.<h3>2. Metrohm: Analysis of fabric softeners and laundry perfumes with NIR spectroscopy</h3>Determination of dry matter, pH, and viscosity in seconds<ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_nir_136_download_0bff06e8c8.pdf">Full PDF for download</a></li></ul>Fabric softeners and laundry perfumes (concentrated fragrances) are a category of personal care/laundry products used for their ability to make textiles softer, smoother, and more pleasantly scented after the washing cycle. A variety of raw materials is necessary to manufacture these products, and different analytical methods are often required before production can commence. Traditional analysis requires time-consuming methods. This Application Note describes how viscosity, dry matter content, and pH level of fabric softeners and laundry perfumes are measured with near-infrared spectroscopy. Nearinfrared spectroscopy (NIRS) is a fast, chemical-free analysis technique for quality control of fabric softeners and laundry perfumes without sample preparation.<h4>EXPERIMENTAL EQUIPMENT&nbsp;</h4>Fabric softener and laundry perfume samples were measured with an <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?manufacturerItems=56&amp;search=OMNIS+NIR">OMNIS NIR</a> Analyzer Solid (Figure 1) in transflection mode (1000–2250 nm) using a 1 mm gap size reflector and 28 mm disposable vials. Reference values of dry matter were measured by loss on drying, and pH and viscosity were determined with a pH meter and viscometer, respectively. <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?manufacturerItems=56&amp;search=OMNIS+Software">OMNIS Software</a> was used for all data acquisition and prediction model development.<h4>RESULT</h4>The obtained NIR spectra (Figure 2) were used to create prediction models for quantification of dry matter, pH value, and viscosity. The quality of the prediction models was evaluated using correlation diagrams (Figures 3–5) which display a very high correlation between the NIR prediction and the reference values. The respective figures of merit (FOM) display the expected precision of a prediction during routine analysis.<h4>CONCLUSION</h4>This Application Note shows the feasibility of the analysis of dry matter, pH, and viscosity in laundry perfumes and fabric softeners with near-infrared spectroscopy. Measurement of all three quality parameters can be conducted within seconds without using any chemicals. NIRS can be used in several steps of the production chain or during quality control of the final product, saving manufacturers time and money. Additionally, with NIRS only one technology is required, compared to the standard analytical techniques often used for these determinations (Table 1).<h3>3. Shimadzu: Content Analysis of Heavy Metals in Soil by ICP-MS</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01002_en_deeffe27a1.pdf">Full PDF for download</a></li></ul><h4>User Benefits</h4><ul><li>High-sensitivity analysis at less than 1/100 of Japan’s soil content standard is possible.</li><li>Correction methods and H2 reaction conditions reduce interference from rare earth elements when measuring As and Se.</li><li>Variation in measurement sensitivity due to the soil matrix is small, enabling stable measurement even when measuring multiple samples over a long time.</li></ul>Soil pollution occurs when chemical or hazardous substances in the soil harm the environment and human health. Soil pollution may be caused by natural phenomena, but most is caused by human activities such as leakage of hazardous substances from industrial activities and improper disposal of waste.In Japan, soil surveys are conducted in accordance with the Soil Contamination Countermeasures Act to prevent harm to human health. These surveys are mandatory when facilities using specified hazardous substances are decommissioned or when the characteristics of land over a certain size have changed. Two types of tests are conducted: soil leaching tests and soil content tests. Soil leaching tests are conducted to evaluate the risk of ingesting groundwater containing hazardous substances leached from the soil, and soil content tests are conducted to evaluate the risk of directly ingesting hazardous substances from the soil through the mouth or skin. The number of such soil surveys is increasing year by year, and since many samples need to be analyzed simultaneously, even in laboratories that accept them, stable and robust analysis equipment isrequired.&nbsp;In this Application News, soil content tests were conducted on five types of soil samples using an <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?manufacturerItems=3&amp;search=ICPMS-2050">ICPMS-2050</a>. The results of the validity of the analysis, the influence of interference from rare earth elements (REE), and long-term stability are also presented.<h4>Conclusion&nbsp;</h4>Soil content tests were conducted using the ICPMS-2050. The measurement sensitivity was 1/100 or less of the soil content standard, and the validity of the measurements was shown by recovery tests, which confirmed that the influence of the matrix was minimal. Interelement correction and half-mass correction are effective for interference from REE, and the correction method can be selected depending on the measurement requirements. Furthermore, it was shown that for Se measurement, the interference from Ar and Gd can be largely eliminated by using H2 reaction conditions. Regarding long-term stability, the variation of the measurement sensitivity was small, and the quantitative values remained stable even when high-matrix samples derived from soil were repeatedly measured. Furthermore, by using the advance rinse function, the sample introduction volume can be reduced, shortening measurement times and improving stability

News from LabRulezICPMS Library - Week 53, 2025

Welcome to our new sample prep technical tip. This month we examine how to extract neutral analytes with ionized interferences.When extracting neutral analytes from an aqueous-based sample matrix (urine, plasma, etc.), it is easy to reach for a reversed phase cartridge (C18, SDBV polymer, etc.).&nbsp;The analytes are retained on the C18 chains via Van der Waals interactions. Polar interferences, such as salts, can be washed from the cartridge using water; less polar interferences can be removed using a small percentage of Methanol (typically around 10 %), again in water. Analytes are typically eluted using 100 % Methanol.There will be occasions where your sample matrix contains acidic or basic impurities that have a relatively high hydrophobicity. Such interferences would be retained at loading, may not be removed during washing, and will probably elute along with your analytes of interest. They may also be found to elute in a similar elution window as your analytes of interest, potentially causing issues with method specificity.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_All_My_Analytes_are_Neutrals_but_Contaminants_are_Acids_or_Amines_What_is_the_Best_Way_to_Concentrate_and_Clean_Up_my_Analytes_of_Interest_1_40abaea792.jpg" alt="Phenomenex: All My Analytes are Neutrals, but Contaminants are Acids or Amines. What is the Best Way to Concentrate and Clean Up my Analytes of Interest?" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_All_My_Analytes_are_Neutrals_but_Contaminants_are_Acids_or_Amines_What_is_the_Best_Way_to_Concentrate_and_Clean_Up_my_Analytes_of_Interest_1_40abaea792.jpg 245w," sizes="100vw" width="857" height="267">If you make use of a mixed mode cartridge instead of using a “straight reversed phase” cartridge, it is possible to remove the charged interferences during the SPE procedure. If we consider neutral compounds in the presence of a hydrophobic base, the first step would be to acidify the sample to ensure that the basic compound is protonated. This can be achieved by the addition of a strong acid such as Hydrochloric Acid (HCl).The pH-adjusted sample can then be loaded onto a conditioned and equilibrated cartridge such as <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2173">Strata™-X-C</a>, shown above. The basic interference will be retained by coulombic attractions on the Sulfonic Acid group shown in red; the analytes of interest by Van der Waals interactions (as seen in a straight reversed phase extraction) through interactions with the rest of the polymer material shown in black.The wash steps should also contain acid, such as dilute HCl, keeping the pH low. In this case, we would wash with 0.1 M HCl to remove polars, and 0.1 M HCl in 10 % Methanol to remove more hydrophobic impurities. The final elution would then be in Methanol. The hydrophobic base will remain inside the cartridge during the elution step.A similar approach, using <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2172">Strata-X-A</a> can be utilized if the removal of acidic compounds is desired. In this case however, rather than using dilute HCl, we would want a buffer around pH 8 for sample adjustment and for using during the wash steps.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Phenomenex_All_My_Analytes_are_Neutrals_but_Contaminants_are_Acids_or_Amines_What_is_the_Best_Way_to_Concentrate_and_Clean_Up_my_Analytes_of_Interest_d92368f829.jpg" alt="Phenomenex: All My Analytes are Neutrals, but Contaminants are Acids or Amines. What is the Best Way to Concentrate and Clean Up my Analytes of Interest?" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Phenomenex_All_My_Analytes_are_Neutrals_but_Contaminants_are_Acids_or_Amines_What_is_the_Best_Way_to_Concentrate_and_Clean_Up_my_Analytes_of_Interest_d92368f829.jpg 245w," sizes="100vw" width="791" height="245">We hope this tip was useful! Check out our resources on <a target="_blank" rel="noopener noreferrer" href="https://www.phenomenex.com/techniques/solid-phase-extraction">solid phase extraction</a>. See you next month for another tip!

All My Analytes are Neutrals, but Contaminants are Acids or Amines. What is the Best Way to Concentrate and Clean Up my Analytes of Interest?

Join us for an insightful interview with Dr. Isaiah Speight, Assistant Professor at William and Mary, as he discusses his groundbreaking work in sustainable chemistry and innovative chromatography techniques. In this engaging conversation, Prof. Speight shares:<ul><li>His research focus on sustainable chemistry from synthesis, financial, and educational perspectives</li><li>The importance of NOBCChE (National Organization for the Professional Advancement of Black Chemists and Chemical Engineers)</li><li>How HPLC and flash chromatography enable synthetic chemistry</li><li>The advantages of automated flash chromatography systems</li><li>Method development processes for new compounds and reactions</li><li>Exciting ongoing projects, including 3D-printed mechanochemical reaction vessels and mercury-centered metal-organic frameworks</li></ul>Discover how Prof. Speight's lab is pushing the boundaries of sustainable chemistry while training the next generation of undergraduate researchers. This interview offers valuable insights for chemists, students, and anyone interested in the future of sustainable scientific practices.<h3>Video Transcription</h3><h4>NOBCChE and Professional Advocacy</h4>Interviewer: We’ve met at ACS meetings where you were representing a student organization. Could you talk about that?Isaiah Spate: Yes, that organization is NOBCChE—the National Organization for the Professional Advancement of Black Chemists and Chemical Engineers. It’s a national organization for both students and professionals, and at the time we met, I was serving on its board.The mission of NOBCChE is to create a supportive space for Black chemists and chemical engineers—to empower them, advocate for them, and help generate opportunities within scientific spaces where advocacy may otherwise be lacking.NOBCChE is a coast-to-coast organization that recently celebrated its 50th anniversary. One of its most powerful qualities is the level of support and openness it provides. There’s a strong sense of creativity—scientific, professional, and entrepreneurial—and a genuine culture of accessibility. First-time attendees can easily engage with senior leadership, and the organization is intentional about creating an environment where people feel safe, empowered, and inspired.<h4>Role of Chromatography in Synthetic Chemistry</h4>Interviewer: You mentioned your group uses HPLC and flash chromatography. How do these fit into your workflow?Isaiah Spate: Although we broadly describe ourselves as a synthetic chemistry group, our work is more targeted toward organic synthesis, which aligns with my institutional role. In practice, synthetic chemistry rarely proceeds cleanly—reactions don’t simply convert reagent A to product C without byproducts or impurities.This is where chromatography becomes essential. Without reliable purification, you’re just carrying impurities forward. Flash chromatography allows us to isolate and purify compounds after reactions, while HPLC is particularly valuable for reaction monitoring, purity assessment, and conversion analysis.High-quality chromatography underpins all downstream characterization. No one trusts NMR data if it’s full of unrelated peaks, so chromatography is foundational to producing meaningful and trustworthy results.<h4>Manual vs. Automated Flash Chromatography</h4>Interviewer: What are the advantages of automated flash chromatography compared to manual columns?Isaiah Spate: Both have value. Running manual columns is extremely important for training—it teaches fundamentals like solvent choice, column packing, flow rate, and separation behavior. That experience builds intuition.Once those fundamentals are understood, automated flash systems become incredibly powerful. They allow for gradient control, reproducibility, scalability, and time efficiency. You can define methods, walk away, and focus on other work.My appreciation for automation really came after running manual columns extensively. Automated systems aren’t just “plug-and-play”—they’re robust tools capable of handling challenging separations when used thoughtfully. That said, there are still times when a manual approach is necessary.<h4>Choosing Between HPLC and Flash Chromatography</h4>Interviewer: What factors influence whether you use HPLC or flash chromatography?Isaiah Spate: In our lab, HPLC is primarily used for reaction monitoring, not large-scale separations. We sample reactions to evaluate conversion, detect impurities, and guide optimization. This approach is common in industry, where in-process checks determine when to move to the next step.Flash chromatography is where we focus on isolation and purity. HPLC may indicate full conversion, but it might miss non-UV-active byproducts. That’s why we also rely on TLC with staining, which can reveal compounds HPLC doesn’t detect.This layered approach—HPLC, TLC, flash chromatography—allows us to fully understand and purify our products, leading to reliable spectral data (NMR, IR, melting point) and reproducible methods.<h4>Method Development and Sustainability</h4>Interviewer: Could you walk us through your method development process?Isaiah Spate: Our group emphasizes mechanochemistry, which often allows reactions to be run solvent-free or with minimal solvent. After reactions are complete, we use traditional tools like TLC and flash chromatography only when necessary.Method development typically follows this sequence:<ol><li>Identify initial reaction conditions from literature or inspiration.</li><li>Use HPLC to optimize reaction performance.</li><li>Scale up slightly to facilitate purification.</li><li>Optimize chromatography separately—often starting with TLC to determine solvent systems, polarity, gradients, or additives.</li><li>Scale purification once conditions are established and document methods thoroughly.</li></ol>We’re very conscious of solvent waste. Even modest manual columns can generate liters of solvent waste, which contradicts the sustainability gains achieved during solvent-free synthesis. Our goal isn’t to avoid chromatography entirely, but to use it strategically and responsibly.<h4>Importance of Method Transparency</h4>Interviewer: You mentioned sample preparation and reporting detail—why is that so important?Isaiah Spate: The best scientific papers are those where you can reproduce the work without guessing. Detailed supplementary information—solvents, concentrations, gradients, purification steps—makes chemistry accessible and robust.Too often, presentations emphasize results without discussing how those results were achieved. Conversations about chromatography conditions, stationary phases, mobile phases, and purification strategies are what enable meaningful scientific exchange.When students and researchers share these details, it elevates the entire field.<h4>Current and Ongoing Research Projects</h4>Interviewer: Are there any projects you can share with us?Isaiah Spate: Yes, several. Our group is part of the NSF Center for the Mechanical Control of Chemistry (CMCC). One project involves 3D-printed mechanochemical reaction vessels designed to retrofit onto rotary evaporators. This dramatically lowers the cost barrier to mechanochemistry, enabling labs without ball mills to participate.Another project explores mechanocatalysis, where the surface of metal reaction vessels—particularly copper—is used as a catalytic component in organometallic transformations.We’re also involved in a three-way collaboration with Caltech and the University of Birmingham on mercury-centered metal–organic frameworks (MOFs). Our group synthesizes the materials, Caltech performs MicroED structural analysis, and Birmingham applies AI and machine learning to predict new structures. The predictions then feed back into experimental validation, creating a closed research loop.<blockquote>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</blockquote><blockquote><h4>Concentrating on Chromatography Podcast</h4>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!You can find Concentrating on Chromatography Podcast in podcast apps:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL">Spotify</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185">Apple podcast</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography">podscan</a></li></ul>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos">YouTube channel</a></blockquote>

 Sustainable Chemistry & Innovative Chromatography: A Conversation with Prof. Isaiah Speight

In the week of January 5 and 12, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>👉 Search and filter in the largest global database with over 5 000 GC, LC, MS and spectroscopy webinars.</blockquote><div><div><div><div><div><div><h5>1. Wasson-ECE Instrumentation: Autosamplers for Gas and LPG Samples</h5><ul><li>Tu, 6.1.2026 21:30 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5531">Registration</a></li></ul>Discover how autosamplers for gas and LPG improve sample handling, accuracy, and efficiency, ensuring reliable results in petrochemical and environmental analysis.<h5>2. Agilent Technologies: The Right Liner for the Right Method – GC Inlet Essentials</h5><ul><li>Th, 8.1.2026 17:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5722">Registration</a></li></ul>Join us as we discuss the different GC inlet liners in our portfolio and help guide you through the selection process for optimal method performance.<h5>3. Wasson-ECE Instrumentation: Process Analyzer Options</h5><ul><li>Tu, 13.1.2026 21:30 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/5532">Registration</a></li></ul>Explore process analyzer options, highlighting configurations, applications, and benefits for real-time monitoring in chemical and petrochemical industries.</div></div></div></div></div></div>

Webinars LabRulezGCMS Week 02-03/2026

In the week of January 5 and 12, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>👉 Search and filter in the largest global database with over 5 000 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. C&amp;EN: PFAS – What’s New and What’s Next</h5><ul><li>Mo, 5.1.2026 17:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5721">Registration</a></li></ul>Get your survival guide to PFAS testing, including regulations, funding, validation tips, EPA 533/537.1 and 1633 guidance, and future trends such as ultrashort PFAS, direct injection, AI, and automation.<h5>2. Agilent Technologies: From Routine to Remarkable LC Analysis – Transforming Productivity with USP 621 Modernization</h5><ul><li>Th, 8.1.2026 06:30 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5768">Registration</a></li></ul>Join this technical webinar to explore the latest permissible changes in USP &lt;621&gt; and learn how they can transform productivity across your LC laboratory ecosystem.<h5>3. SCIEX: Accurate Mass Fundamentals – What It Is and Why It Matters</h5><ul><li>We, 14.1.2026 19:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5770">Registration</a></li></ul>Session 1 introduces accurate mass fundamentals, explaining why mass accuracy and resolution matter, what nominal mass can miss, and how accurate mass improves data interpretation and confidence.<h5>4. Shimadzu Corporation: Latest Biopharma Innovation – Autonomous, Scalable &amp; Cost-Effective Solutions for Downstream Processing</h5><ul><li>Th, 15.1.2026 05:30 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/5753">Registration</a></li></ul>Discover how Shimadzu and Sepragen deliver end-to-end bioprocessing solutions, from analytical HPLC to scalable chromatography systems, enabling efficient scale-up, regulatory compliance, and cost savings.<h5>5. Agilent Technologies: Effortless UV-VIS Analysis with Long Pathlength Measurements</h5><ul><li>Th, 15.1.2026 20:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/3912">Registration</a></li></ul>Learn how the Cary 3500’s flexible long-pathlength sampling options make concentration analysis simpler and more efficient than ever.

Webinars LabRulezLCMS Week 02-03/2026

In the week from January 5 and 12, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>👉 Search and filter in the largest global database with over 5 000 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. Agilent Technologies: Elemental Analysis of Alloy Samples on an Agilent ICP-OES</h5><ul><li>Tu, 6.1.2026 21:30 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5451">Registration</a></li></ul>Learn how Agilent ICP-OES enables precise alloy analysis by addressing spectral interferences and wide dynamic range requirements to deliver reliable industrial results.<h5>2. Mettler-Toledo: Characterization of Composite Materials by Thermal Analysis</h5><ul><li>Th, 8.1.2026 08:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/5732">Registration</a></li></ul>Learn how thermal analysis (DSC, TGA, TMA, DMA) characterizes modern composites—from Tg and curing to stiffness and delamination—supporting R&amp;D and QC workflows.<h5>3. Agilent Technologies: The Importance of Controlling Contamination and Choosing the Right Sample Introduction System</h5><ul><li>Tu, 13.1.2026 21:30 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/2597">Registration</a></li></ul>Even before analysis begins, controlling environmental contamination and selecting the right sample introduction system is the first step toward achieving the best detection limits.<h5>4. Agilent Technologies: Effortless UV-VIS Analysis with Long Pathlength Measurements</h5><ul><li>Th, 15.1.2026 20:00 CET</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/3912">Registration</a></li></ul>Discover how the Cary 3500’s flexible long-pathlength sampling options make concentration analysis simpler and more efficient than ever.

Webinars LabRulezICPMS Week 02-03/2026

Article

Product

Events

Webinars

Application

Academy

Video

Poster

Scientists

Plastics

Environment

Food

Water

Health

Presentation

Scientific article

Interview

Toxicology

Popularization

Science and research

Software

Covid-19

Career

Laboratories

Various

PFAS 

Zaměření

Type of News

Focus

A unique company dedicated to serving science helping our customers drive productivity and accelerate results. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services.

Thermo Fisher Scientific

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Phenomenex is a global technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers in industrial, government and academic laboratories.

Phenomenex

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

For over 200 years we have been helping people and organizations develop the skills and knowledge they need to succeed.
We develop digital education, learning, assessment, and certification solutions to help universities, businesses, and individuals move between education and employment and achieve their ambitions.

Webinars LabRulezICPMS Week 02-03/2026

Webinars LabRulezLCMS Week 02-03/2026

Webinars LabRulezGCMS Week 02-03/2026

Sustainable Chemistry & Innovative Chromatography: A Conversation with Prof. Isaiah Speight

All My Analytes are Neutrals, but Contaminants are Acids or Amines. What is the Best Way to Concentrate and Clean Up my Analytes of Interest?

News from LabRulezICPMS Library - Week 53, 2025

News from LabRulezLCMS Library - Week 53, 2025

News from LabRulezGCMS Library - Week 53, 2025

Scaling Up Biopharmaceutical Characterization with the Orbitrap Ascend BioPharma Tribrid Mass Spectrometer

ChromSolutions Ltd Advances Untargeted Compound Analysis for its Customers with Wiley's KnowItAll Software

Upcoming events

LECO Training Course Pegasus BT/BT4D BTX/BTX4D

LECO Training Course CS-744/844 Series & ON/ONH-736/836 Series

SCIEX at SOFT/TIAFT

Webinars

Strengthening SPE Workflows for Today’s Laboratory

From Crude to Candidate: Scaling Preparative Chromatography with Confidence

How Do You Tackle Sample Prep for Diverse SVOCs?