<p><strong>In the week from February 3, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>4 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Agilent Technologies: Peak Perfection: A Guide to GC troubleshooting</strong></h5><div><div><ul><li><div>Tu, 4.2.2025 17:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4514">Registration</a></div></li></ul></div><p>We will discuss some of the most common chromatographic issues that you experience with Gas Chromatography and take a logical approach to finding the root cause and correcting the problem.</p></div><h5><strong>2. GERSTEL: Determination of mineral oil residues HPLC-GC analysis of MOSH &amp; MOAH</strong></h5><div><div><ul><li><div>We, 5.2.2025 10:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4639">Registration</a></div></li></ul></div><p>Experience the LC-GC-FID analysis for MOSH/MOAH in our informative webinar! We will introduce you to the key features of the GERSTEL LC-GC-FID system and show you how it simplifies your daily work.</p></div><h5><strong>3. DataApex: Clarity 10 Webinar</strong></h5><div><div><ul><li><div>Th, 6.2.2025 09:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4696">Registration</a></div></li></ul></div><p>Discover the new Dual Chromatogram Mode for dual tower samplers, enhanced User Account settings, updated control modules, Extensions' improvements, and more.</p></div><h5><strong>4. Anton Paar: Data Integrity - the Anton Paar way</strong></h5><div><div><ul><li><div>Th, 6.2.2025 10:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4551">Registration</a></div></li></ul></div><p>Data integrity has now been extended from the device to the AP Connect Pharma edition. This software allows you to store, verify, and validate your data easily in your own SQL database.</p></div><h5><strong>5. Technology Networks: Toward More Sustainable Labs: The Impact of Gas Supply</strong></h5><div><div><ul><li><div>Th, 6.2.2025 15:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4690">Registration</a></div></li></ul></div><p>This webinar will discuss the improvements you could make to your lab’s sustainability goals with the introduction of on-site gas generation.</p></div><h5><strong>6. Agilent Technologies: Eliminate errors with automation and stress-free sample tracking</strong></h5><div><div><ul><li><div>Th, 6.2.2025 17:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/4571">Registration</a></div></li></ul></div><p>Join us to hear about a new technology, linking samples and software for unprecedented control, to give you confidence in your laboratory workflow.</p></div>

Webinars LabRulezGCMS Week 6/2025

<p><strong>In the week of February 3, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over&nbsp;</p><p><strong>4 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Shimadzu Corporation: Analyzing Consumer Products for PFAS: New Method Development</strong></h5><div><div><ul><li><div>Mo, 3.2.2025 20:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4466">Registration</a></div></li></ul></div><p>Learn how to test nonvolatile and semi-volatile PFAS compounds in consumer products by LC-MS/MS as outlined in a method being standardized by ASTM.</p></div><h5><strong>2.&nbsp;Thermo Fisher Scientific: Methods for plasma proteomics at large scale and high-throughput</strong></h5><div><div><ul><li><div>Tu, 4.2.2025 11:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4693">Registration</a></div></li></ul></div><p>The presentation highlights the integration of advanced proteomics technologies, particularly mass spectrometry, into clinical research and diagnostics.</p></div><h5><strong>3.&nbsp;GERSTEL: Determination of mineral oil residues HPLC-GC analysis of MOSH &amp; MOAH</strong></h5><div><div><ul><li><div>We, 5.2.2025 10:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4639">Registration</a></div></li></ul></div><p>Experience the LC-GC-FID analysis for MOSH/MOAH in our informative webinar! We will introduce you to the key features of the GERSTEL LC-GC-FID system and show you how it simplifies your daily work.</p></div><h5><strong>4.&nbsp;DataApex: Clarity 10 Webinar</strong></h5><div><div><ul><li><div>Th, 6.2.2025 09:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4696">Registration</a></div></li></ul></div><p>Discover the new Dual Chromatogram Mode for dual tower samplers, enhanced User Account settings, updated control modules, Extensions' improvements, and more.</p></div><h5><strong>5.&nbsp;Thermo Fisher Scientific: Navigating proteomics techniques for molecular profiling of clinical cancer cohorts</strong></h5><div><div><ul><li><div>Th, 6.2.2025 11:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4694">Registration</a></div></li></ul></div><p>The presentation explores the integration of proteomics into clinical practice, particularly in cancer research and emphasizes the use of mass spectrometry-based proteomics.</p></div><h5><strong>6.&nbsp;Technology Networks/Peak Scientific: Toward More Sustainable Labs: The Impact of Gas Supply</strong></h5><div><div><ul><li><div>Th, 6.2.2025 15:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4690">Registration</a></div></li></ul></div><p>This webinar will discuss the improvements you could make to your lab’s sustainability goals with the introduction of on-site gas generation.</p></div><h5><strong>7.&nbsp;Agilent Technologies: Eliminate errors with automation and stress-free sample tracking</strong></h5><div><div><ul><li><div>Th, 6.2.2025 17:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/4571">Registration</a></div></li></ul></div><p>Join us to hear about a new technology, linking samples and software for unprecedented control, to give you confidence in your laboratory workflow.</p></div>

Webinars LabRulezLCMS Week 6/2025

<p><strong>In the week from February 3, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry</strong></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></p><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>4 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Mettler-Toledo: Improve Dairy Processing</strong></h5><div><div><ul><li><div>Tu, 4.2.2025 09:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4655">Registration</a></div></li></ul></div><p>The impact of pH on dairy production, issues with lab pH measurement, the value of continuous pH data and how the latest pH measurement systems can improve dairy processing.</p></div><h5><strong>2.&nbsp;Anton Paar: Optimizing Animal Feed Production: Mixing, Extrusion, Texture, and Tribology</strong></h5><div><div><ul><li><div>Tu, 4.2.2025 18:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4452">Registration</a></div></li></ul></div><p>This webinar will introduce both single and twin-screw extrusion techniques for lab-scale animal food production.</p></div><h5><strong>3.&nbsp;Agilent Technologies: Learn Why Atomic Absorption, MicroWave, and ICP Plasma Spectroscopy are the Perfect Tools for Both a Teaching and Research Environment</strong></h5><div><div><ul><li><div>Tu, 4.2.2025 19:00 (CET)</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/3158">Registration</a></div></li></ul></div><p>We will discuss each of the above techniques and outline the advantages and challenges of each.</p></div><h5><strong>4.&nbsp;Anton Paar: Scratch Measurement Optimization</strong></h5><div><div><ul><li><div>Tu, 4.2.2025 20:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4450">Registration</a></div></li></ul></div><p>Explore how to fine-tune scratch test parameters for your specific needs.</p></div><h5><strong>5.&nbsp;Agilent Technologies: Atomic Spectroscopy</strong></h5><div><div><ul><li><div>Th, 6.2.2025 04:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4672">Registration</a></div></li></ul></div><p>In order to increase the effectiveness and productivity of elemental analysis in food and environmental samples, in this first session we will exchange tips and the newest Agilent technology available.</p></div><h5><strong>6.&nbsp;Anton Paar: Data Integrity - the Anton Paar way</strong></h5><div><div><ul><li><div>Th, 6.2.2025 10:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4551">Registration</a></div></li></ul></div><p>Data integrity has now been extended from the device to the AP Connect Pharma edition. This software allows you to store, verify, and validate your data easily in your own SQL database.</p></div><h5><strong>7.&nbsp;Separation Science/Agilent Technologies: Improving Efficiency with Challenging ICP-OES Applications Utilizing a Robust Sample Introduction System</strong></h5><div><div><ul><li><div>Th, 6.2.2025 11:00 CET</div></li><li><div><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/4684">Registration</a></div></li></ul></div><p>In this webinar, we'll provide an overview of some new sample introduction components that remove pain points around running challenging sample matrices by ICP-OES efficiently.</p></div>

Webinars LabRulezICPMS Week 6/2025

<h4><strong>A Beginner’s Guide to Multidimensional Chromatography</strong></h4><ul><li><strong>Instructors:</strong> <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/articles?search=Pierre-Hugues+Stefanuto"><strong>Pierre-Hugues Stefanuto</strong></a>, <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/articles?search=Katelynn+Perrault+Uptmor"><strong>Katelynn Perrault Uptmor</strong></a>, <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/articles?search=Dwight+Stoll"><strong>Dwight Stoll</strong></a>, <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/articles?search=Petr+Vozka"><strong>Petr Vozka</strong></a></li></ul><h5><strong>Course Description</strong></h5><p>So...you <strong>want to do multidimensional chromatography</strong>? If you are getting started in the field using either <strong>liquid or gas chromatography</strong>, you’re in the right place.</p><p>This course will cover a brief <strong>history and introduction</strong> to both multidimensional gas chromatography and multidimensional liquid chromatography.</p><p>Discussion will also include basic <strong>system components</strong> and <strong>data handling strategies</strong> to apply after acquiring your data.&nbsp;</p><p><strong>A hands-on portion</strong> of the course will also include familiarization with common system components and consumables for both GC and LC, as well as the opportunity to use a <strong>commercial GC×GC instrument</strong>.</p><figure class="image"><img style="aspect-ratio:2016/1163;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_16th_MDCW_2025_Short_Course_Day_0_Instructors_Pierre_Hugues_Stefanuto_Katelynn_Perrault_Uptmor_Petr_Vozka_Dwight_Stoll_c7823e807e.jpg" alt="MDCW: 16th MDCW 2025 - Short Course (Day 0) Instructors - Pierre-Hugues Stefanuto, Katelynn Perrault Uptmor, Petr Vozka, Dwight Stoll" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MDCW_16th_MDCW_2025_Short_Course_Day_0_Instructors_Pierre_Hugues_Stefanuto_Katelynn_Perrault_Uptmor_Petr_Vozka_Dwight_Stoll_c7823e807e.jpg 245w," sizes="100vw" width="2016" height="1163"></figure><h5><strong>Target Participants</strong></h5><p>This course is intended to be an initial touchpoint for those who are looking <strong>to explore multidimensional chromatography</strong> as a new option/capability, or who might be using it for the first time. The course is intended for new users to obtain a background on the techniques as a primer to the workshop. &nbsp;Advanced topics will not be discussed.</p><blockquote><h4><strong>SHORT COURSE SPONSORS 2025</strong></h4><ul><li><strong>Acesss</strong></li><li><strong>Certech</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_MDCW_2025_Short_Course_Sponsors_17c5136804.jpg" alt="MDCW 2025: Short Course Sponsors." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MDCW_MDCW_2025_Short_Course_Sponsors_17c5136804.jpg 245w," sizes="100vw" width="1314" height="406"></p></blockquote><h3><strong>Agenda</strong></h3><h4><strong>Part I – History, Terminology, Fundamental Concepts</strong></h4><ul><li>Brief history of the development of multidimensional separations</li><li>Terminology</li><li>Fundamental Concepts</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_16th_MDCW_2025_Short_Course_Day_0_2_39321d7512.jpg" alt="MDCW: 16th MDCW 2025 - Short Course (Day 0)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MDCW_16th_MDCW_2025_Short_Course_Day_0_2_39321d7512.jpg 245w," sizes="100vw" width="2016" height="963"></p><h4><strong>Part II – Introduction to Multidimensional Gas Chromatography</strong></h4><ul><li>Method basics (column selection, method parameters, carrier gas choices, detector considerations)</li><li>Modulator selection (thermal, flow, others)</li><li>Method development made simple</li><li>Data preprocessing and initial handling</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_16th_MDCW_2025_Short_Course_Day_0_1_17b90a9c53.jpg" alt="MDCW: 16th MDCW 2025 - Short Course (Day 0)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MDCW_16th_MDCW_2025_Short_Course_Day_0_1_17b90a9c53.jpg 117w," sizes="100vw" width="1512" height="2016"></p><h4><strong>Part III – Introduction to Multidimensional Liquid Chromatography</strong></h4><ul><li>Modes of multidimensional separation commonly used with LC (heartcut, multiple<br>heartcut/selective comprehensive, fully comprehensive)</li><li>Interfaces used for multidimensional LC</li><li>Common use cases of multidimensional LC ( industry and academic research examples)</li><li>Introduction to method development strategies</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_16th_MDCW_2025_Short_Course_Day_0_Part_IV_Laboratory_Session_5c0228ff66.jpg" alt="MDCW: 16th MDCW 2025 - Short Course (Day 0) Part IV – Laboratory Session" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MDCW_16th_MDCW_2025_Short_Course_Day_0_Part_IV_Laboratory_Session_5c0228ff66.jpg 245w," sizes="100vw" width="2016" height="1040"></p><h4><strong>Part IV – Laboratory Session</strong></h4><p>Participants will be put in small groups and rotate to different stations to familiarize with a variety of<br>GC and LC components used for multidimensional systems including:</p><ul><li>Rotation 1: 2D LC – Interfaces, valves, columns, acquisition software</li><li>Rotation 2: GC×GC – Tuning, sequence setup, acquisition</li><li>Rotation 3: GC×GC – Hardware and consumables</li><li>Rotation 4: GC×GC – Data processing examples</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_16th_MDCW_2025_Short_Course_Day_0_Rotation_1_2_D_LC_Interfaces_valves_columns_acquisition_software_bb39a29c27.jpg" alt="MDCW: 16th MDCW 2025 - Short Course (Day 0) Rotation 1 2D LC – Interfaces, valves, columns, acquisition software" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MDCW_16th_MDCW_2025_Short_Course_Day_0_Rotation_1_2_D_LC_Interfaces_valves_columns_acquisition_software_bb39a29c27.jpg 188w," sizes="100vw" width="1512" height="1257"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_16th_MDCW_2025_Short_Course_Day_0_Rotation_2_GC_GC_Tuning_sequence_setup_acquisition_7e06c1acba.jpg" alt="MDCW: 16th MDCW 2025 - Short Course (Day 0) Rotation 2 - GC×GC – Tuning, sequence setup, acquisition" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MDCW_16th_MDCW_2025_Short_Course_Day_0_Rotation_2_GC_GC_Tuning_sequence_setup_acquisition_7e06c1acba.jpg 245w," sizes="100vw" width="2284" height="1153"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_16th_MDCW_2025_Short_Course_Day_0_Rotation_3_GC_GC_Hardware_and_consumables_6b0ec5e8ea.jpg" alt="MDCW: 16th MDCW 2025 - Short Course (Day 0) Rotation 3 GC×GC – Hardware and consumables" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MDCW_16th_MDCW_2025_Short_Course_Day_0_Rotation_3_GC_GC_Hardware_and_consumables_6b0ec5e8ea.jpg 245w," sizes="100vw" width="2016" height="889"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_16th_MDCW_2025_Short_Course_Day_0_Rotation_4_GC_GC_Data_processing_examples_e06f63f4d9.jpg" alt="MDCW: 16th MDCW 2025 - Short Course (Day 0) Rotation 4 - GC×GC – Data processing examples" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MDCW_16th_MDCW_2025_Short_Course_Day_0_Rotation_4_GC_GC_Data_processing_examples_e06f63f4d9.jpg 164w," sizes="100vw" width="1512" height="1445"></p>

16th MDCW 2025 - Short Course (Day 0)

<h3><strong>Program MONDAY February 3, 2025</strong></h3><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.multidimensionalchromatography.com/uploads/5/8/9/1/58913545/_final_16mdcw_guidebook.pdf"><strong>Final Guidebook (PDF)</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.multidimensionalchromatography.com/uploads/5/8/9/1/58913545/_global_abstract.pdf"><strong>Abstract Book (PDF)</strong></a></li></ul><h5>8:00 - 8:30 AM Registration</h5><h5>8:30 - 9:00 AM - <strong>Introducing Supercritical Fluid Chromatography in the Community of Multidimensional Chromatography</strong></h5><ul><li>Karine Faure (Institut of Analytical Sciences, CNRS Universite Lyon, France)</li></ul><p>In recent years, multidimensional liquid chromatography has received increasing attention due to the desire to better resolve non-volatile compounds in complex samples. The selection of chromatographic modes in each dimension is of paramount importance to ensure the orthogonality of the overall 2D separation.</p><p>To overcome the limitations encountered in the analysis of non-ionisable molecules, the use of supercritical fluid chromatography (SFC) combined with polar stationary phases is considered as a potential dimension of interest. This contribution reports on the advantages of comprehensive RPLC×SFC separation for the characterisation of valuable bio-wastes (wood lignin, spent ground coffee) and the incorporation of renewable materials into industrial products. Recent advances in modulation interfaces for on-line coupling of LC and SFC are described.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_Karine_Faure_Introducing_Supercritical_Fluid_Chromatography_5ffe948e36.jpg" alt="MDCW: Karine Faure - Introducing Supercritical Fluid Chromatography in the Community of Multidimensional Chromatography" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MDCW_Karine_Faure_Introducing_Supercritical_Fluid_Chromatography_5ffe948e36.jpg 245w," sizes="100vw" width="2284" height="1453"></p><h5>9:00 - 9:30 AM - <strong>GC×GC-MS - Fragrance Allergens - The Olympic Gold Standard</strong></h5><ul><li>Thomas Dutriez (Givaudan International, Product Safety Science Laboratories CoE, Vernier, Switzerland)</li></ul><p>On July 26, 2023, the European Commission (EC) published amendment 2023/1545<sup>1 </sup>to Annex III of the Cosmetic Products Regulation, significantly expanding the number of fragrance allergens from 24 to 57 organic compounds for which presence should be indicated on the product’s label when above the established thresholds for leave-on and rinse off products (0.001 and 0.01%). The labelling of cosmetic products placed on the EU market will therefore be impacted over a period of 3 to 5 years.</p><p>While the percentage of consumers developing allergic contact dermatitis remains low, the extended list of 57 fragrance allergens corresponds to typical perfume notes commonly found in fragrance raw materials (more than 99% of natural ingredients contain at least one allergen).</p><p>Accurate determination of fragrance allergens levels is a crucial activity for the fragrance industry to comply with legislation and to provide robust data to customers, together with perfumers during the creation step. However, this remains an analytical challenge regarding the quantification of a wide range of different chemical structures (i), across a large concentration range from ppm to high percentage levels (ii), and in complex natural substances potentially containing more than 10’000 different molecules (iii).</p><p>The fragrance industry has developed technical recommendations<sup>2,3</sup> to address this target quantitation analysis: GC-MS technology, two different stationary phases, SIM/Scan acquisition and a decision tree for data processing. Although the classical GC-MS approach, involving two different devices, can provide sufficient data confidence for simple raw materials, it becomes a daunting task when dealing with natural substances owing to multiple co-elutions with matrix peaks. For instance, for a complex essential oil, up to 16 GC-MS runs may be required to cover the full concentration range of allergens. Advanced MS technologies, such as MS-MS or HR-MS, have been recently proposed but cannot differentiate molecules having the same elemental formula or MS fragments, like terpenes or terpenoids.</p><p>Comprehensive two-dimensional gas chromatography (GC×GC-TOFMS) is the technology of choice to fully overcome co-elution issues in natural samples. Dedicated GC×GC conditions have been developed through a patented method<sup>4</sup> that helps select the best optimal parameters to maximize the separation between targets and the separation capacity. As a result, a unique normal hybrid configuration (Mid-polar × Polar) has proven to separate all fragrance allergens, even the discrete isomers, in a single run while providing a very high observed peak capacity of 5000. The developed methodology, based on GC×GC-MS for content level up to 3% and calibrated FID data for higher percentages, provides excellent performance: no compromise in separation, very high data confidence for unambiguous identification and quantification, a maximum of three data sets for complex substances and a streamlined semi-automated data process.</p><p>With more than 10,000 analyses and a daily use over the past 10 years, this state-of-the-art method is at the heart of a monitoring program for regulated substances, in new or existing ingredients, and for customer questions.</p><p>GC×GC-TOFMS has become the gold standard for quantifying fragrance allergens due to its unsurpassed performance and user-friendly technology.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_Thomas_Dutriez_GC_GC_MS_Fragrance_Allergens_The_Olympic_Gold_Standard_18974f5da5.jpg" alt="MDCW: Thomas Dutriez - GC×GC-MS - Fragrance Allergens - The Olympic Gold Standard" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MDCW_Thomas_Dutriez_GC_GC_MS_Fragrance_Allergens_The_Olympic_Gold_Standard_18974f5da5.jpg 245w," sizes="100vw" width="2284" height="1392"></p><h5>9:30 - 9:50 AM - <strong>Development of a multiple heart-cut SFC-SFC setup</strong></h5><ul><li>Clément De Saint Jores</li></ul><h5>9:50 - 10:10 AM - <strong>Toward unrivaled chromatographic resolving power in proteomics: Design and development of comprehensive spatial three-dimensional liquid-phase separation technology</strong></h5><ul><li>Sebastiaan Eeltink</li></ul><h5>10:10 - 10:40 AM Coffee Break and <strong>poster session</strong></h5><figure class="image"><img style="aspect-ratio:1512/2016;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_Coffee_Break_and_Poster_session_2_cb767d8c78.jpg" alt="MDCW: Coffee Break and Poster session" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MDCW_Coffee_Break_and_Poster_session_2_cb767d8c78.jpg 117w," sizes="100vw" width="1512" height="2016"></figure><h5>10:40 - 11:00 AM - <strong>Enhanced chiral screening of complex samples via aqueous achiral × chiral comprehensive liquid chromatography</strong></h5><ul><li>Frederic lynen&nbsp;</li></ul><h5>11:00 - 11:20 AM - <strong>Application of 2D-LC to the analysis of chiral and other isomeric molecules in biosciences</strong></h5><ul><li>Michael Laemmerhofer</li></ul><blockquote><h4><strong>GOLD SPONSORS 2025</strong></h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.leco.com/"><strong>LECO</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.jeolbenelux.com/"><strong>JEOL</strong></a></li></ul><p><img style="aspect-ratio:1283/384;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_MDCW_2025_Gold_Sponsors_97685a5688.jpg" alt="MDCW: MDCW 2025 Gold Sponsors." width="1283" height="384"></p></blockquote><h5>11:20 - 11:40 AM - <strong>One-step-microwave-assisted extraction and derivatization followed by comprehensive two-dimensional chromatography coupled with flame ionization detector to analyze fatty acid methyl esters (FAMEs) in complex food matrices.</strong></h5><ul><li>Donatella Ferrara</li></ul><h5>11:40 - 12:00 AM - <strong>Profiling phenolic compounds in shea by comprehensive two-dimensional liquid chromatography hyphenated to ion mobility spectrometry and high-resolution mass spectrometry</strong></h5><ul><li>Nikoline J. Nielsen&nbsp;</li></ul><h5>12:00 - 12:20 PM - <strong>Investigating the impact of packaging on oat volatiles using GC×GC–TOF MS</strong></h5><ul><li>Steve Smith (SepSolve Analytical, United Kingdom)</li></ul><p>Investigating the migration of volatiles from food packaging is essential for ensuring the safety, quality, and sensory integrity of food products.. Packaging materials can release volatiles that may migrate into the food over time, significantly affecting the sensory characteristics of food, altering its taste, aroma, and overall consumer appeal. Understanding the extent and mechanisms of this migration is vital not only for meeting stringent food safety regulations but also for developing packaging solutions that minimise these interactions.</p><p>However, the study of volatiles in complex food matrices requires advanced analytical techniques due to the low concentrations and diverse nature of the compounds. Traditional methods, such as SPME–GC–MS, often lack the sensitivity and resolution needed to fully characterise the volatile composition.</p><p>Here, we employ headspace sorptive extraction and GC×GC-TOF MS to investigate the volatile profiles of oats. The high-capacity probes enable efficient extraction and pre-concentration of a wide range of trace-level volatiles, while GC×GC-TOF MS provides exceptional separation and identification capabilities. This powerful combination allows for a detailed investigation of the volatile profile of foods and the potential impact of packaging materials on these profiles.</p><p>We apply this approach to analyse volatiles from six brands of packaged oats. Using sophisticated chemometrics workflows, we identify key differentiators among the packaging materials—cardboard, paper, and plastic—and analyse the volatiles emitted from these sources to confirm and understand migration patterns.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_Steve_Smith_Investigating_the_impact_of_packaging_on_oat_volatiles_using_GC_GC_TOF_MS_f9c95070e0.jpg" alt="MDCW: Steve Smith - Investigating the impact of packaging on oat volatiles using GC×GC–TOF MS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MDCW_Steve_Smith_Investigating_the_impact_of_packaging_on_oat_volatiles_using_GC_GC_TOF_MS_f9c95070e0.jpg 233w," sizes="100vw" width="2284" height="1532"></p><h5>12:20 - 12:40 PM - <strong>Non-targeted analysis of PFAS using two dimensional gas chromatography</strong></h5><ul><li>Christopher Freye&nbsp;</li></ul><h5>12:40 - 1:30 PM Lunch</h5><h5>1:30 - 1:40 PM - <strong>The LabRulez portals – a unique source of information not only in the field of GC×GC and 2DLC</strong></h5><ul><li>Ivo Novotný</li></ul><h5>1:40 - 1:50 PM - <strong>Coupling of VAC-HS-SPME and GC×GC-QMS for simultaneous 5-HMF quantification and volatile profiling in honey</strong></h5><ul><li>Damien Eggermont</li></ul><h5>1:50 - 2:00 PM - <strong>MOSH&amp;MOAH in food ingredients and additives, and the advantages of using LC/GC×GC(-FID/TOFMS) for their analysis</strong></h5><ul><li>Aleksandra Gorska</li></ul><p>Mineral oil saturated hydrocarbons (MOSH) and mineral oil aromatic hydrocarbons (MOAH) are contaminants of increasing concern for the food industry due to their widespread occurrence and uncertain toxicity. The ISO 20122:2024 is currently the only official method for their analysis, and it has only been validated on several vegetable oils. The workflow consists of extensive sample preparation followed by LC-GC-FID analysis. However, many challenges remain with this analysis. Accurate quantification is often difficult, particularly when biogenic substances coelute with MOSH or MOAH unresolved complex mixtures (UCMs). In these cases, chromatogram integration is largely based on the operator's interpretation.</p><p>Switching to LC-GC×GC-FID has proven to be a useful approach to reduce the uncertainty associated with interpretation. The second GC dimension helps differentiate biogenic compounds from MOSH and MOAH. Adding mass spectrometry (MS) detection further enhances the ability to distinguish coeluting substances. These advantages make LC-GC×GC-FID/TOFMS particularly useful for investigating MOSH/MOAH contamination in new matrices, where the present interferences are not yet well understood.</p><p>This presentation will illustrate the advantages of LC-GC×GC-FID/TOFMS for analysing MOSH/MOAH in food ingredients and additives, for which limited data is available. Additionally, it will show how the LC step preceding GC analysis, which initially serves to separate MOSH from MOAH and retain more polar compounds, can also help reduce or eliminate certain interferences.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_Aleksandra_Gorska_MOSH_and_MOAH_in_food_ingredients_and_additives_and_the_advantages_of_using_LC_GC_GC_FID_TOFMS_for_their_analysis_b9bca1249f.jpg" alt="MDCW: Aleksandra Gorska - MOSH&amp;MOAH in food ingredients and additives, and the advantages of using LC/GC×GC(-FID/TOFMS) for their analysis" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MDCW_Aleksandra_Gorska_MOSH_and_MOAH_in_food_ingredients_and_additives_and_the_advantages_of_using_LC_GC_GC_FID_TOFMS_for_their_analysis_b9bca1249f.jpg 245w," sizes="100vw" width="1612" height="951"></p><h5>2:00 - 2:10 PM - <strong>Automation and challenges in one-and-dimensional liquid chromatography method development: what is optimal?</strong></h5><ul><li>Tijmen S. Bos&nbsp;</li></ul><h5>2:10 - 2:20 PM - <strong>Forensic olfactronics and human scent signatures created from GC×GC-MS data</strong></h5><ul><li>Stepan Urban&nbsp;</li></ul><h5>2:20 - 2:30 PM - <strong>Development and testing of a non-contact scent collection device on real human scent</strong></h5><ul><li>Oleksii Kaminskyi</li></ul><h5>2:30 - 2:40 PM - <strong>Towards a better understanding of the body volatolome: focus on endogenous parameters influencing body volatolome composition</strong></h5><ul><li>Elsa Boudard</li></ul><h5>2:40 - 2:50 PM - <strong>Method optimization of fingermark residue using comprehensive two-dimensional gas chromatography</strong></h5><ul><li>Emma Macturk (William &amp; Mary, Williamsburg, USA)</li></ul><p>Optimization is a crucial step in method development of routine analytical techniques. Fingermark residue, consisting of sweat and oil from sebaceous glands, is a complex biological mixture with fatty acids, fatty alcohols, and steroid hormones. Fingermarks have been analyzed using techniques such as liquid chromatography, capillary electrophoresis, and gas chromatography (GC) all coupled to mass spectrometry. There has been little research however in full, nontargeted characterization of fingermark residue using advanced chromatographic methods such as comprehensive two-dimensional gas chromatography (GC×GC-TOFMS). The goal of this study was to optimize a method for the nontargeted analysis of fingermark residue using GC×GC-TOFMS.</p><p>A starting method based on a one-dimensional GC and GC×GC comparison was used to analyze residue samples. Full method optimization included testing five parameters (modulation period, hot pulse time, hold time at oven start, hold time at oven end, and oven ramp rate) with three options each and one parameter (secondary oven offset) with two options. Parameter options were compared to each other as a group and the best option chosen for the optimized method. The optimized method was evaluated as a whole with all optimized parameters. Fingermark deposition, regeneration, and sample preparation were optimized with different extraction processes with the goal of quantitation of analytes. Method optimization using GC×GC fully resolved hidden peaks such as the steroid hormone allopregnane. A fully optimized method will be used in future studies to differentiate between endogenous fingermark compounds and exogenous contamination compounds from the environment.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_Emma_Macturk_Method_optimization_of_fingermark_residue_using_comprehensive_two_dimensional_gas_chromatography_25a6b92c16.jpg" alt="MDCW: Emma Macturk - Method optimization of fingermark residue using comprehensive two-dimensional gas chromatography" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MDCW_Emma_Macturk_Method_optimization_of_fingermark_residue_using_comprehensive_two_dimensional_gas_chromatography_25a6b92c16.jpg 245w," sizes="100vw" width="1612" height="1006"></p><h5>2:50 - 3:00 PM - <strong>Sex and person identity recognition from GC×GC analysis of scent samples</strong></h5><ul><li>Jan Hlavsa</li></ul><h5>3:00 - 3:10 PM - <strong>The impact of the menstrual cycle on skin volatile profiles</strong></h5><ul><li>Marion Risse</li></ul><h5>3:10 - 4:30 PM Coffee Break and <strong>Poster session</strong></h5><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_Coffee_Break_and_Poster_session_91aa1b84c3.jpg" alt="MDCW: Coffee Break and Poster session" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MDCW_Coffee_Break_and_Poster_session_91aa1b84c3.jpg 181w," sizes="100vw" width="1512" height="1307"></p><h5>4:30 - 5:30 PM <strong>Guided Discussion: Transition to green chemistry, challenges and opportunities for analytical revolution</strong></h5><h5>7:00 PM <strong>Conference dinner at the Liège University Aquarium-Muséum</strong></h5><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/MDCW_16th_Multidimensional_Chromatography_Workshop_MDCW_45f4f47a21.jpg" alt="MDCW: 16th Multidimensional Chromatography Workshop (MDCW)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_MDCW_16th_Multidimensional_Chromatography_Workshop_MDCW_45f4f47a21.jpg 117w," sizes="100vw" width="1512" height="2016"></p>

16th MDCW 2025 (Day 1)

<p><strong>Tailored for laboratories seeking precision, efficiency, and scalability, Chrom SST is the ultimate tool for streamlining data processing and generating AI-ready insights.</strong></p><h5><strong>Key Features:</strong></h5><ul><li>Automated Data Processing and Analysis</li><li>Customizable and Re-usable Methods</li><li>Easy-to-interpret Pass/Fail Results</li><li>Compatible with Various Chromatography Systems</li><li>Supports Diverse Output Formats</li></ul><h3><strong>Why Choose Chrom SST?</strong></h3><p>Chrom SST transforms laboratory operations by <strong>centralizing data management </strong>and consolidating results from multiple instruments into a unified repository for seamless dashboarding and performance monitoring. It <strong>enables 24/7 operations</strong> and <strong>scheduled tests - </strong>eliminating the need for human intervention and minimizing instrument downtime. Designed for scalability, Chrom SST ensures <strong>consistent performance</strong> across growing workloads, diverse instruments, and expanding teams.</p><p>By adopting Chrom SST, laboratories can <strong>enhance efficiency and productivity</strong> while leveraging <strong>predictive insights</strong> to optimize instrument uptime and maintain uninterrupted operations.</p><p>Learn more about <a target="_blank" rel="noopener noreferrer" href="https://mestrelab.com/main-product/chrom-sst?utm_source=adv&amp;utm_medium=labrulez&amp;utm_campaign=feb&amp;utm_term=chrom%20sst"><strong>Chrom SST</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://www2.mestrelab.com/l/271522/2025-01-31/3thx58"><strong>request a demo</strong></a> to see how it can revolutionize your lab operations.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Mestrelab_Introducing_Chrom_SST_Automated_and_Accurate_Instrument_Performance_Insights_af0c39857d.jpg" alt="Mestrelab: Introducing Chrom SST Automated and Accurate Instrument Performance Insights" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Mestrelab_Introducing_Chrom_SST_Automated_and_Accurate_Instrument_Performance_Insights_af0c39857d.jpg 245w," sizes="100vw" width="1920" height="1080"></p>

Introducing Chrom SST: Automated and Accurate Instrument Performance Insights

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 3rd February 2025? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you applications and other documents by <strong>Shimadzu, Agilent Technologies </strong>and <strong>Thermo Fisher Scientific</strong>!</p><h4><strong>1. Analysis of Essential Oils Using Comprehensive Two-Dimensional Gas Chromatography (GC × GC) and High-Resolution Mass Spectrometer</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_essential_oil_analysis_gcxgc_5994_8029en_agilent_7f4357b3cd.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The analysis of complex samples such as essential oils can benefit substantially from comprehensive two-dimensional gas chromatography (GC × GC), which provides a high degree of chromatographic separation due to the second dimension. Combining GC × GC with high-resolution accurate mass measurement increases the number of identifiable components and enhances confidence in the results.</p><p>The focus of this study was to establish a workflow for the analysis of essential oils using GC × GC with a reverse flow modulator (RFM) combined with a high-resolution quadrupole time-of-flight (GC/Q-TOF) mass spectrometer.</p><h5><strong>Experimental</strong></h5><p>The samples were separated on an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=8890"><strong>Agilent 8890 GC</strong></a> using a GC × GC configuration with an RFM and analyzed using a high-resolution accurate mass <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=7250"><strong>Agilent 7250 GC/Q-TOF MS</strong></a> as well as an FID. A "normal" column set, combining a nonpolar primary column and a polar secondary column, was used. This set consisted of a 20 m × 0.1 mm, 0.1 μm Agilent DB-1ms column (100% dimethylpolysiloxane) and a 5 m × 0.25 mm, 0.15 μm Agilent DB-17ms column (equivalent to (50%-phenyl)-methylpolysiloxane).</p><p>To decrease flow to the MS, and to add an FID to the configuration as a second detector, the column flow must be split at the end of the secondary column by connecting it to a splitter. Two splitter types, purged and unpurged, have been explored to highlight the benefits and limitations of each configuration. In the case of a purged splitter, the column flow mixes with the makeup flow before splitting between the two detectors. In contrast, an unpurged splitter does not use makeup flow when splitting the column effluent between the two restrictors connected to the two detectors. A second FID (monitor, or vent) channel was added for method optimization and troubleshooting.</p><h5><strong>Conclusion</strong></h5><p>In this application note, a method for the analysis of essential oils using several comprehensive GC × GC configurations with a reverse flow modulator (RFM) and a high-resolution Agilent 7250 GC/Q-TOF system was developed. Method optimization was performed using a diesel sample. Essential oil components, separated by GC × GC, were reliably identified using the Unknowns Analysis tool. Agilent Mass Profiler Professional (MPP) software successfully determined the differences in chemical composition between the essential oils.</p><h4><strong>2.&nbsp;Utilizing hydrogen carrier gas for sensitive analysis of pesticides in food using gas chromatography mass spectrometry</strong></h4><ul><li>Poster / ASMS</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_142_utilizing_hydrogen_pesticides_food_gc_ms_po142_asms2024_en_7ed0951b93.pdf"><strong>Full PDF for download</strong></a></li></ul><p><strong>Purpose:</strong> To demonstrate the performance of the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=3&amp;search=HeSaver"><strong>Thermo Scientifc HeSaver-H2Safer kit </strong></a>for iConnect split-splitless (SSL) injection module for trace analysis of pesticides using H2 as a carrier gas as a safe and sustainable solution for laboratory operations.</p><p><strong>Methods: </strong>In this study, hydrogen was used as a carrier gas for <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?instrumentationItems=15&amp;mainauthorItems=3"><strong>GC-MS/MS analysis</strong></a> of trace levels of pesticides in food. The GC was fitted with a new hydrogen safer split/splitless injector, with chromatographic separation performed on a TG-5 SIL MS(30 m × 0.25 mm, 0.25 μm) capillary GC column. The chromatographic conditions applied ensured critical pair separation was achieved. The GC-MS/MS system was equipped with an advanced electron ionization (AEI) source to increase sensitivity for analyte detection. Quantification and assessment of critical regulatory requirements, such as linearity and sensitivity, were performed in a single software.</p><h5><strong>Conclusions</strong></h5><ul><li>The use of the HeSaver-H2Safer technology allows for a safe and compliant use of hydrogen as an alternative carrier gas in GC/GC-MS applications without the need to install a hydrogen sensor and removes any risk of unwanted reactions with the sample in the hot SSL injector.</li><li>When used with hydrogen, the limited carrier gas consumption offered by the HeSaver-H2Safer mode permits a very controlled system demand for hydrogen, making this solution ideal for laboratories working with hydrogen generators.</li><li>Migrating the GC-MS/MS method from helium to hydrogen requires an adaptation of method parameters to address (i.e., retention time shift and different fragmentation patterns).</li><li>97% of pesticides in baby food and 98% in honey showed a linear response in the concentration range 0.005–0.500 mg/kg and the relative standard deviation for N=5 repeats of each sample type at 0.01 mg/kg was equal or lower than 10% for 98% of the evaluated compounds.</li></ul><h4><strong>3.&nbsp;Analysis of VOC and SVOC Emissions from Automotive Interior Materials Using GCMS-QP2050 in Accordance with ISO 12219-11</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_00845_en_9771953555.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>The <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=QP2050"><strong>GCMS-QP2050</strong></a> features a new interface that enables good peak shape and sensitivity even when analyzing compounds with high boiling points.</li><li>When used with the <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=1&amp;search=TD-30R"><strong>TD-30R</strong></a> thermal desorption system, it can analyze compounds in accordance with ISO 12219-11.</li><li>The TVOC Calculation Tool can calculate in a simple manner quantitative emissions (toluene and hexadecane equivalents) in accordance with ISO 12219-11.</li></ul><h5><strong>Introduction</strong></h5><p>In recent years, measures to reduce the use of organic compounds in automotive interiors have progressed, the ISO 12219-11 standard is being developed for the analysis of volatile organic compounds (VOCs) and semi-volatile organic compounds (SVOCs) that are emitted from automotive interior materials. The ISO 12219-11 analytical procedure involves filling a thermal desorption (TD) glass tube with a sample of materials, heating the tube using TD, and loading the VOCs (up to C25) and SVOCs (C14 to C32) that were emitted from the sample into a GC-MS system for analysis. Although this standardized procedure enables simple and quick analysis of VOC and SVOC emissions from these materials, contamination of the MS system caused by the simultaneous loading of compounds with high boiling points is a problem.</p><p>As shown in Fig. 1, the GCMS-QP2050 is equipped with a new contamination-resistant ion optical system that effectively minimizes contamination of the MS. Featuring a new interface (Fig. 2) that enables good peak shape and sensitivity even for compounds that are typically prone to adsorption, it is optimally suited to analyzing SVOCs, including those with high boiling points.</p><p>TD-30R and GCMS-QP2020 NX will be listed as examples for suitable test equipment on ISO 12219-11. This Application News describes analyzing VOC and SVOC emissions from the materials of vehicle interiors in compliance with ISO 12219-11 using the GCMS-QP2050 together with the NexisTM GC-2030 and the TD-30R thermal desorption system.</p><h5><strong>Conclusion</strong></h5><p>Using the new GCMS-QP2050, it was possible to consistently analyze SVOCs and other compounds with high boiling points. By combining this system with the TD-30R thermal desorption system and the TVOC Calculation Tool, even inexperienced users can rapidly analyze automotive interior materials and quantify emissions (i.e., calculate toluene and hexadecane equivalents) in compliance with ISO 12219-11.</p>

News from LabRulezGCMS Library - Week 6, 2025

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 3rd February 2025? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you tech. note by <strong>Agilent Technologies, </strong>applications by <strong>Shimadzu, Thermo Fisher Scientific, Metrohm,</strong> and Poster by <strong>Waters Corporation</strong>!</p><h4><strong>1. Simultaneous Determination of Five Genotoxic Aryl Sulfonate Impurities in Pharmaceuticals by LCMS-2050</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_03_lcms_053_en_befdf50f8c.pdf">Full PDF for download</a></li></ul><h5><strong>User Benefit</strong></h5><ul><li>A novel method for determining the content of five genotoxic aromatic sulfonate impurities in drugs was established by using <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=1&amp;search=2050"><strong>LCMS-2050 single quadrupole mass spectrometer</strong></a>.</li><li>The pretreatment of this method was simple, and it had a wide linear range and a high accuracy rate.</li></ul><h5><strong>Introduction</strong></h5><p>Genotoxic impurities (GTIs) refer to substances that directly or indirectly damage cellular DNA, generating gene mutations or in vivo mutagenesis. GITs may can cause damage to human genetic material at extremely low concentrations, which in turn leads to gene mutations and promotes the occurrence of tumors. Because of the potential risks of GITs, it is essential to monitor any potentially existing genotoxic impurities in active pharmaceutical ingredients or medicinal products.</p><p>In the pharmaceutical industry, when drug active ingredients exist in the forms of alkyl sulfonates, benzenesulfonates, p-toluenesulfonates, and hydroxyethyl sulfonates or sulfonic acid reagents are utilized in the drug synthesis process, sulfonate esters are regarded as potential GTIs. GTIs of sulfonate esters can be classified as alkyl sulfonate esters and aryl sulfonate esters based on different substituents.</p><p>Previously, relevant literature has reported quantitative detection methods for some GTIs of sulfonate esters, such as GC-MS, GC-FID, LC-MS/MS, and complex derivatization treatment of samples might be necessary. In this study, LC-MS was mainly utilized for the quantitative analysis of five GTIs of aryl sulfonate esters. This method features simple pretreatment and high accuracy, which can offer a reference for the detection of genotoxic impurities of aryl sulfonate esters in drugs.</p><h5><strong>Conclusion</strong></h5><p>A novel method for determining the content of five genotoxic impurity aryl sulfonates in drugs was established by using the LCMS-2050. Within the concentration range of 5 - 500 μg/L, the correlation coefficients of the five genotoxic impurity aryl sulfonates were all greater than 0.994. When a mixed standard solution of three concentrations was added to the drugs, the recovery rates of each component ranged from 110.5% to 115.3%. This method features simple pretreatment, excellent specificity and high sensitivity, and can provide a reference for the determination of the content of five genotoxic impurities aryl sulfonates in drugs.</p><h4><strong>2.&nbsp;Method Transfer from an Agilent 1100 Series Quaternary LC to an Agilent 1260 Infinity III LC</strong></h4><ul><li>Technical Overview</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/te_method_transfer_equivalency_1100_series_1260_infinity_iii_5994_8031en_agilent_1_b429e7bd87.pdf">Full PDF for download</a></li></ul><p><strong>Proof of equivalency for the transfer of conventional LC methods</strong></p><p>Method transfer from legacy equipment to new instruments, such as the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=10&amp;search=1260+Infinity+III"><strong>Agilent 1260 Infinity III LC</strong></a>, is an important topic for all laboratories throughout different industries. Seamless method transfer ensures that the same methods can still be used, which ensures business continuity and reduced regulatory and financial risks.</p><p>This technical overview demonstrates method transfer from an <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=10&amp;search=1100"><strong>Agilent 1100 Series Quaternary LC</strong></a> to an Agilent 1260 Infinity III LC for conventional LC methods covering diverse gradient conditions. Equivalent results are obtained, which proves that seamless method transfer can be expected for typical, robust, conventional LC methods. In terms of retention time precision, the 1260 Infinity III LC outperforms the 1100 LC, leading to higher trust in the data.</p><h5><strong>Introduction</strong></h5><p>Method transfer is an important topic for all laboratories throughout different industries, where HPLC methods are transferred between departments and locations as well as between different LC instruments.<sup>1</sup> For validated methods in the pharmaceutical industry, method transferability is compulsory.</p><p>Method transfer, or the transfer of analytical procedures from one laboratory to another in the pharmaceutical industry requires a documented process that requires comparative testing.<sup>2</sup> One example for instrument-to-instrument method transfer is the transfer of conventional LC methods from legacy equipment to new instruments such as a 1260 Infinity III LC.</p><p>This technical overview demonstrates method transfer from a 1100 Series Quaternary LC to a 1260 Infinity III LC for conventional LC methods. Several methods were chosen that cover diverse gradient conditions including challenging conditions such as a shallow gradient and a gradient starting at a composition extreme. This should prove that equivalent results are obtained when transferring methods from a broad application space of conventional LC methods from the 1100 Series Quaternary LC to the 1260 Infinity III LC.</p><p><strong>Conclusion</strong></p><p>The transfer of conventional LC methods covering diverse gradient conditions from an Agilent 1100 Series Quaternary LC to an Agilent 1260 Infinity III LC leads to equivalent results, thereby proving that seamless method transfer can be expected for typical, robust, conventional LC methods. In terms of retention time precision, the 1260 Infinity III LC outperforms the 1100 LC, leading to a higher trust in the data.</p><h4><strong>3.&nbsp;Development of Separation Methods for GLP-1 Synthetic Peptides Utilizing a Systematic Protocol and MaxPeak High Performance Surface Technology</strong></h4><ul><li>Poster / HPLC Symposium</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/2024_hplc_bengtson_glp1_synthetic_peptides_7d92bb96e7.pdf">Full PDF for download</a></li></ul><p>Peptides offer higher specificity than small molecules, and low immunogenicity which makes them excellent candidates for new medications. Specifically synthetic peptides produced through solid phase peptide synthesis allow for more control with more predictable impurities with a relatively low manufacturing cost.</p><p>An excellent example of upcoming synthetic peptide drugs is Glucagon-Like Peptide-1 Agonists (GLP-1s) which are prescribed for the treatment and management of obesity and type-II diabetes1. Recently, GLP-1 drugs such as semaglutide, have boomed in popularity as a weight management treatment after success in clinical trials.2 Given the prevalence of GLP-1s, it is important that the quality control for this class of pharmaceuticals is supported by versatile, sensitive, and reproducible chromatography methods.</p><p>Here we address these needs and developed a single HLPC-UV/MS method for the analysis of a variety of GLP-1s. The experiment was based around a systematic protocol which was key in helping to identify high-risk factors and to shorten the method development time. Beyond this <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=5&amp;search=MaxPeak+HPS"><strong>MaxPeak high performance (HPS)</strong></a> technology was used to improve chromatographic performance.</p><h5><strong>Conslusion</strong></h5><p>The thoughought assessment of the risk before conduction the development of a separation method allowed for the ccreation of a more quality method while reducing time. Asessing the high risk variables showed ther benefit in MaxPeak HPS technology when working with these compounds. MaxPeak HPS technology</p><h4><strong>4.&nbsp;Quantifying impurities in cationic lipids raw materials with the inverse gradient method using LC-CAD-MS</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_003384_pb_cationic_lipids_isq_lc_cad_ms_an003384_na_en_d3a34737de.pdf">Full PDF for download</a></li></ul><h5><strong>Application benefits</strong></h5><ul><li>Enable the quantification of impurities even in the absence of specific reference standards</li><li>Use a single quadrupole mass spectrometer to match impurities based on their retention time and molecular masses</li><li>Use an inverse gradient with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=3&amp;search=Charged+Aerosol+CAD"><strong>Charged Aerosol Detector (CAD)</strong></a> to enable accurate surrogate quantitation when there is large difference in retention times between the lipid standard and its impurities, even in the absence of impurity standards</li><li>Confirm the unit mass of both the lipid standard and its associated impurities using the correlation of CAD and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=3&amp;search=ISQ"><strong>ISQ channels</strong></a></li></ul><h5><strong>Goal</strong></h5><ul><li>Provide instructions, methodologies, and recommended techniques to improve quantification of impurities in cationic lipid components</li><li>Use the Thermo Scientific™ Vanquish™ Flex Inverse Gradient UHPLC System coupled to a Thermo Scientific™ Vanquish™ Charged Aerosol Detetor to provide more accurate estimated quantitation of cationic lipid impurities without the need for reference standards</li></ul><h5><strong>Conclusion</strong></h5><p>In this study, we have developed an inverse gradient quantification method for cationic lipids impurity analysis when impurity reference standards are not available. For further identification of lipid impurities, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_002455_bt_lc_cad_hram_ms_lipid_nanoparticle_an002455_na_en_2c6a86ecac/an-002455-bt-lc-cad-hram-ms-lipid-nanoparticle-an002455-na-en.pdf"><strong>Application Note 002455</strong></a> can be referenced.</p><ul><li>The impurity amount can be automatically estimated using another peak or peak group within the same run for this surrogate quantitation in Chromeleon CDS.</li><li>Both inverse gradient configuration and method can be automatically generated via the wizard.</li><li>When there is a significant difference in retention times between the lipid standard and its impurities, using an inverse gradient provides more accurate estimated quantitation than a conventional gradient method.</li><li>The use of the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=3&amp;search=ISQ"><strong>ISQ EM MS</strong></a> in conjunction with CAD allowed for confirmation of the m/z of the lipid raw material as well as determination of the m/z for the unknown impurities.</li></ul><h4><strong>5.&nbsp;Using a portable standalone system for easy fermentation monitoring</strong></h4><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_ec_035_download_f48491e484.pdf">Full PDF for download</a></li></ul><p><strong>In-situ measurements of lactic acid in beer using screen-printed electrodes (SPEs)</strong></p><p>Lactic acid (2-hydroxypropanoic acid) is primarily found in sour dairy products. In beer, the presence of lactic acid contributes to its acidity and lactic aromas, and usually appears as the result of fermentation with lactic acid bacteria. These bacteria may be purposely introduced to the wort, or they can also appear as a result of an infection.</p><p>Although lactic acid is essential in beer up to a certain amount, in excess it is considered a defect. Its perception threshold is 0.0044 mol/L. However, in some lambic-type beers, the lactic acid concentration can reach levels higher than 0.0333 mol/L.</p><p>In this Application Note, an enzymatic sensor based on a screen-printed electrode is used to measure lactic acid in commercial beers as a proof of concept for its potential application during fermentation monitoring.</p><p><strong>Conclusion</strong></p><p>In this study, an electrochemical biosensor for the detection of lactic acid in beer is proposed. The sample with the electrochemical method proposed only needs to be diluted 1:10 with a solution of 0.1 mol/L Tris-NO<sub>3</sub> at pH 7.2. Using a simple amperometric assay, it is possible in 75 s to measure the amount of lactic acid in a beer sample without any pretreatment. Measurements obtained are similar to those taken with a traditional L-Lactate Assay kit and non-portable optical devices</p>

News from LabRulezLCMS Library - Week 6, 2025

16th MDCW 2025 (Day 2)

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 3rd February 2025? Check out new documents from the field of spectroscopy/spectrometry and related techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring you applications by <strong>Shimadzu, Agilent Technologies </strong>and<strong> Thermo Fisher Scientific!</strong></p><h4><strong>1. Shimadzu: Simultaneous TG/DTA - DTG-60 Series</strong></h4><ul><li>Product note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/c161_e005_0b449915ae.pdf">Full PDF for download</a></li></ul><p>This instrument varies the sample temperature in accordance with a program, and simultaneously measures the change in mass of the sample (TG) and the temperature difference between the sample and a standard substance (DTA).</p><ul><li>High-Sensitivity and High-Accuracy Measurement</li><li>Supports Various Types of Measurement</li><li>Automated Functions Increase Throughput</li><li>Complies with Analysis Laboratory Regulations</li><li>Compact Design</li></ul><h4><strong>2.&nbsp;Agilent Technologies: Capabilities and Operation of the Advanced Dilution System 2</strong></h4><ul><li>Technical Overview</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/te_ads_2_icp_5994_7211en_agilent_631a8d1650.pdf">Full PDF for download</a></li></ul><p><strong>Automate calibration and sample dilution for Agilent ICP-OES and ICP-MS instruments</strong></p><p>Now, more than ever, laboratories worldwide are facing increasing challenges to perform more analyses with fewer resources, prompting a re-evaluation of many analytical practices. Automation of certain tasks can help lab managers to streamline workflows and optimize resource utilization. To increase the efficiency of labs equipped with Agilent ICP-OES or ICP-MS instrumentation, Agilent has developed the Advanced Dilution System 2 (ADS 2)—a fully integrated inline autodilution system designed for routine, high throughput applications. The ADS 2 can automatically dilute stock standards and samples up to 400 times, making it ideal for the auto-preparation of calibration standards and samples, or dilution of overrange samples. The ADS 2 effectively reduces the number of manual tasks that operators have to perform when preparing a quantitative method for ICP-OES or ICP-MS, allowing more time to work on other tasks.</p><p>The two-syringe ADS 2 is available for the Agilent 5800 and 5900 ICP-OES* and Agilent 7850, 7900, and 8900 ICP-MS*. The ADS 2 and Advanced Valve System (AVS)** work seamlessly together under software control to maximize sample throughput, increase sample turn-around-time, and reduce cost-per-sample. The integrated design of the ADS 2 and AVS avoids adding excess time when not performing a dilution, addressing a common drawback of other dilution systems. The design also ensures that the system remains readily available to provide inline sample dilution whenever needed. If a reactive dilution of a sample is required, the intelligent software conveniently presents the results for the diluted sample at the end of each worksheet run, while retaining full access to all data.</p><h4><strong>3.&nbsp;Thermo Fisher Scientific: Thermo Scientific iCAP MX Series ICP-MS - Fully automatic start up and performance verification</strong></h4><ul><li>Product spotlight</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/sl_002910_tea_qtegra_isds_software_get_ready_sl002910_em_en_9e1bfd41ac.pdf">Full PDF for download</a></li></ul><p>The Thermo Scientific™ iCAP™ MX Series ICP-MS instruments provide sensitive, accurate, and robust analysis of a wide variety of sample matrices. Designed with ease of use and intelligent solutions to time-consuming steps in the daily laboratory in mind, the Get Ready process allows for automatic and unattended instrument initialization and performance verification.</p><p>Inductively coupled plasma-mass spectrometry (ICP-MS) is a powerful technology for trace and ultra-trace determination of elemental impurities in various markets, including environmental and food safety testing, industrial applications, clinical analysis, and research. In recent years, ICP-MS has become not only more sensitive to improve detection of lower concentrations, but also more robust to replace analyses previously run on ICP-optical emission spectroscopy (ICP-OES) instruments.</p><p>Another emerging trend is an increase in automation of labor-intensive and time-consuming steps in sample preparation and analysis. With increased demands on flexibility, both from clients demanding results with short turnover time as well as laboratory personnel looking for more flexible work arrangements, automated and timed start of the analytical system is an area to improve on efficiency and productivity in the laboratory.</p>

News from LabRulezICPMS Library - Week 6, 2025

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