<p><strong>What if you could assess a tumor's metastatic potential — without extensive sample prep — directly from tissue? Rachel Wood is working on exactly that.</strong></p><p><strong>Rachel Wood</strong> is a PhD candidate at Queen's University (Kingston, Ontario),&nbsp;working jointly in the labs of Dr. Richard Oleschuk (Chemistry) and Dr. Chris&nbsp;Nicoll (Pathology &amp; Molecular Medicine). Her research applies Ambient Ionization Mass Spectrometry — specifically the Liquid Microjunction Surface Sampling Probe &nbsp;(LMJ-SSP) and Desorption Electrospray Ionization (DESI) — to profile the metabolomics of non-metastatic and metastatic clear cell Renal Cell Carcinoma (ccRCC) cell lines. The long-term goal: a rapid, minimally invasive MS-based prognostic tool for kidney cancer.</p><p>This is the first reported use of LMJ-SSP to assess metastatic status in ccRCC —&nbsp;and early PCA results are already showing distinct separation between cell line&nbsp;<br>profiles.</p><h5><strong>In this episode, David and Rachel cover:</strong></h5><ul><li>Why <strong>ccRCC</strong> is such a resistant biomarker problem despite active genomic, proteomic, and metabolomic research</li><li>The clinical stakes of "<strong>diagnosed by accident</strong>" — and what a prognostic biomarker actually needs to do for a clinician</li><li>How AIMS complements (not replaces) LC-MS in a discovery-phase cancer workflow</li><li><strong>LMJ-SSP vs. DESI</strong>: what each technique sees that the other misses, including spatial resolution differences (~1mm vs. ~50µm)</li><li>Why Rachel runs LMJ-SSP on both a triple quad and a Q-TOF — and what each instrument contributes to the same research question</li><li>How her lab repurposed a 3D printer as a custom automated XYZ sampling stage with 50µm movement precision</li><li>Managing high-dimensional metabolomics data across two polarities, two cell lines, and two mass analyzers — the pipeline explained</li><li>What unsupervised machine learning (PCA) showed in early results</li><li>The path from cell lines to excised tumor tissue to, ultimately, liquid biopsies</li><li>Advice for analytical chemists considering work at the chemistry–oncology interface</li></ul><h3><strong>Video Transcription</strong></h3><p><strong>Kidney cancer remains a difficult biomarker problem, particularly when researchers try to distinguish tumors that are likely to behave aggressively from those that are not. In a recent episode of </strong><i><strong>Concentrating on Chromatography</strong></i><strong>, PhD researcher Rachel Wood discussed how she is combining rapid ambient ionization mass spectrometry, LMJ-SSP, DESI, multivariate data analysis, and conventional LC-MS workflows to investigate the molecular differences associated with clear cell renal cell carcinoma and its metastatic potential.</strong></p><h4><strong>Returning to the research question that started it all</strong></h4><p>Wood first encountered kidney cancer research during her undergraduate studies. Although she later moved into a more instrumentation-focused master’s project involving breast cancer, the subject of kidney cancer remained unfinished business.</p><p>When the opportunity arose to choose a PhD project, she returned to the field that had originally sparked her interest in research. She is now conducting her doctoral work at <strong>Queen’s University in Kingston, Ontario</strong>, in an interdisciplinary environment spanning chemistry, pathology, molecular medicine, computer science, and clinical research.</p><h4><strong>Why clear cell renal cell carcinoma is such a difficult biomarker problem</strong></h4><p>Wood’s research focuses on <strong>clear cell renal cell carcinoma (ccRCC)</strong>, which represents the majority of kidney cancer cases discussed in the interview.</p><p>The difficulty is not a lack of research effort. Genomics, proteomics, and metabolomics studies have all produced promising biomarker candidates. The challenge is that different studies often identify different sets of markers, with relatively little overlap between them.</p><p>Patient-to-patient biological variability further complicates the picture. A candidate biomarker panel that performs well in one cohort may not reproduce equally well in another. Selecting which features deserve further investigation therefore becomes a major analytical and biological challenge.</p><h4><strong>From incidental diagnosis to prognostic information</strong></h4><p>Another difficulty is the way kidney cancer is often discovered.</p><p>Rather than being detected through a dedicated screening program, tumors may be found incidentally during imaging performed for another reason. According to Wood, the ideal solution would be a diagnostic biomarker capable of detecting kidney cancer early. Such a marker is not currently available within the scope of the work she described.</p><p>That places additional importance on <strong>prognostic biomarkers</strong>. Once a tumor has been detected, clinicians need as much information as possible about how aggressive it may be and how likely it is to progress.</p><p>Wood’s current work is therefore not attempting to declare directly that a particular patient has metastatic disease. Instead, the goal is to understand <strong>what changes biologically as a tumor moves from a less aggressive to a more aggressive state</strong>.</p><p>That means asking which molecular pathways change, which mechanisms become altered, and which analytes may eventually provide useful indicators of tumor behavior.</p><h4><strong>AIMS and LC-MS answer different questions</strong></h4><p>A central theme of the interview was the relationship between rapid ambient ionization mass spectrometry and conventional LC-MS.</p><p>Wood is clear that <strong>AIMS is not intended to replace LC-MS</strong>. Instead, she sees the two approaches as complementary.</p><p>AIMS provides a rapid way to obtain a broad molecular overview of a sample with minimal preparation. This makes it especially useful during the discovery phase, when the goal is to gather as much molecular information as possible and identify features that distinguish biological groups.</p><p>LC-MS then becomes valuable when those features need to be separated, characterized more carefully, and quantified with greater confidence.</p><p>In Wood’s workflow, rapid MS screening can therefore help identify which analytes deserve closer attention before more targeted LC-MS investigations are performed.</p><h4><strong>What “minimal sample preparation” actually means</strong></h4><p>The amount of sample preparation required depends strongly on the type of material being analyzed.</p><p>Wood currently works mainly with <strong>cultured human cell lines</strong>, which means much of the preparation begins with growing the cells themselves. Depending on the experiment, the cells may then be chemically lysed or subjected to fixation, paraffin embedding, and sectioning before analysis by <strong>LMJ-SSP</strong> or <strong>DESI</strong>.</p><p>She also notes that the possibilities would be different for freshly excised tumor material. In an appropriate perioperative or biosafety laboratory setting, LMJ-SSP could potentially be used to analyze tumor margins more directly.</p><p>The practical meaning of “minimal preparation” is therefore highly dependent on the sample and the analytical question being asked.</p><h4><strong>Why combine LMJ-SSP and DESI?</strong></h4><p>Rather than choosing between LMJ-SSP and DESI, Wood uses the two approaches because they provide different types of information.</p><p><strong>LMJ-SSP</strong> offers rapid, localized analysis and can accommodate samples with uneven surface topography, which is particularly useful for excised tissue.</p><p><strong>DESI</strong>, by contrast, provides substantially higher spatial resolution. In the workflow described in the interview, DESI can achieve spatial resolution on the order of tens of micrometers, whereas LMJ-SSP operates at a much larger sampling scale depending on probe design.</p><p>That higher spatial resolution is important when moving from simplified cell-line models toward actual tumor tissue, where the molecular organization of different regions may reveal biologically relevant differences.</p><p>Combining both techniques therefore enables researchers to balance speed, surface compatibility, and spatial information.</p><h4><strong>Two mass analyzers for two parts of the same problem</strong></h4><p>Wood also uses two different mass spectrometers in her LMJ-SSP work.</p><p>Most of the discovery work is carried out using a <strong>triple quadrupole mass spectrometer</strong>, particularly because her project focuses strongly on lower-mass analytes and small molecules.</p><p>Once statistically important analytes have been identified, a <strong>Q-TOF</strong> instrument can be used for MS/MS experiments and tentative structural identification.</p><p>The two instruments therefore address different stages of the workflow: one supports broad discovery and comparison, while the other provides additional structural information needed to connect selected features with possible metabolic pathways.</p><h4><strong>Turning a 3D printer into an automated sampling platform</strong></h4><p>One of the most unusual elements of the project is the automated sampling system used with LMJ-SSP.</p><p>Historically, LMJ-SSP measurements could be performed manually or with custom-built XYZ positioning stages. Wood’s laboratory instead adapted a <strong>3D printer</strong> into an automated positioning system.</p><p>Custom software controls the printer and moves the sampling probe with precise control over its X, Y, and Z positions. According to Wood, the system enables movements down to approximately <strong>50 µm</strong> and also controls parameters such as the contact time between the probe and sample and the delay between consecutive sampling events.</p><p>This level of automation improves reproducibility because variables that would otherwise depend on manual operation can be controlled systematically.</p><p>Even the Z-position can be programmed, allowing the probe to operate at constant or varying heights depending on the sample surface.</p><h4><strong>Managing high-dimensional MS data</strong></h4><p>The experimental design creates a large data-analysis challenge.</p><p>Wood is working with multiple cell lines, both ionization polarities, and more than one mass analyzer. To maintain traceability, she analyzes the data in clearly defined subsets.</p><p>A typical workflow might begin with one mass analyzer and one polarity. Within that condition, the lower-aggressiveness and higher-aggressiveness cell models can then be compared directly.</p><p>The data processing pipeline includes steps such as:</p><ul><li>binning,</li><li>normalization,</li><li>transformation,</li><li>dimensionality reduction,</li><li>identification of discriminating molecular features.</li></ul><p>Once relevant features are identified, MS/MS analysis can be used to investigate them further. The same process is then repeated across other polarities and instruments.</p><h4><strong>Unsupervised machine learning reveals distinct molecular profiles</strong></h4><p>Machine learning is particularly valuable because the AIMS datasets are highly dimensional, containing very large numbers of molecular features across multiple samples.</p><p>Wood’s initial analysis has included <strong>principal component analysis (PCA)</strong>, an unsupervised dimensionality-reduction technique.</p><p>The early results are encouraging: the non-metastatic and metastatic cell-line models separate clearly in PCA space.</p><p>That does not itself identify a definitive biomarker panel, but it indicates that the two biological states have distinguishable molecular profiles even though both belong to the same kidney cancer subtype.</p><p>This provides an important foundation for identifying which specific metabolites or molecular pathways may be responsible for the separation.</p><h4><strong>Testing LMJ-SSP for metastatic status</strong></h4><p>A particularly novel aspect of Wood’s project is the use of LMJ-SSP to investigate differences associated with metastatic status.</p><p>She had previously worked on distinguishing healthy and cancerous tissues, where the biological differences are relatively large. Comparing two states within the same cancer type is more demanding because the molecular changes may be much subtler.</p><p>The scientific motivation, however, is strong. Tumors discovered at later stages carry greater concern for metastatic progression, making it important to understand the molecular changes associated with increasingly aggressive behavior.</p><p>For Wood, this made the methodological risk worthwhile: the analytical challenge directly addresses an area where better prognostic information could ultimately have clinical value.</p><h4><strong>A long-term goal: rapid MS-based prognostic testing</strong></h4><p>The long-term vision extends beyond cell-line research.</p><p>Wood is interested in whether rapid, minimally invasive mass spectrometry could eventually contribute to clinical decision-making.</p><p>One possibility would be identifying a diagnostic biomarker in a <strong>liquid biopsy</strong>, potentially using blood or urine. A urine-based marker capable of contributing to earlier detection would be particularly attractive for kidney cancer.</p><p>For prognostic applications, the goal would be slightly different. Once a tumor is discovered, molecular information could help characterize its likely behavior and provide clinicians with additional evidence when deciding between immediate treatment, surgery, or other management strategies.</p><p>Wood emphasizes that such a tool would not replace standard clinical workflows. Instead, it would provide additional molecular information to complement existing diagnostic and pathological approaches.</p><h4><strong>Why interdisciplinary work matters</strong></h4><p>Throughout the interview, Wood repeatedly returns to the importance of collaboration.</p><p>Her research sits at the intersection of analytical chemistry, pathology, oncology, computation, and clinical medicine. No single researcher can remain equally current in all of these fields.</p><p>Working closely with pathologists, computer scientists, surgeons, medical students, and other specialists therefore provides both scientific expertise and a way to stay connected with developments outside one’s immediate discipline.</p><p>For Wood, the biological context has also changed how she thinks about analytical chemistry. Developing a new instrument or method is important, but understanding <strong>who may ultimately benefit from that analytical capability</strong> makes the research more meaningful.</p><p>That patient-centered perspective is now an integral part of how she approaches the project.</p><h4><strong>An intersection full of opportunities</strong></h4><p>Wood describes the interface between analytical chemistry and oncology as an especially exciting area for young researchers.</p><p>The work can range from troubleshooting instrumentation to interpreting pathology, developing statistical methods, and collaborating across disciplines. That diversity creates constant opportunities to learn and to apply analytical chemistry to clinically relevant questions.</p><p>Her project illustrates that modern mass spectrometry research is increasingly about more than generating spectra. It involves connecting instrumentation, spatial sampling, multivariate statistics, machine learning, biological interpretation, and clinical needs into a single analytical strategy.</p><p>And in kidney cancer, where reliable prognostic biomarkers remain difficult to establish, that integrated approach may be particularly valuable.</p><blockquote><p><strong>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</strong></p></blockquote><blockquote><h4><strong>Concentrating on Chromatography Podcast</strong></h4><p>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!</p><p>You can find <strong>Concentrating on Chromatography Podcast </strong>in podcast apps:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL"><strong>Spotify</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185"><strong>Apple podcast</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography"><strong>podscan</strong></a></li></ul><p>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos"><strong>YouTube channel</strong></a></p></blockquote>

AIMS vs. LC-MS for Cancer Diagnostics: ccRCC Metabolomics with Rachel Wood

<p><strong>In the week of September 21, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>6 000 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Waters Corporation: Strengthening SPE Workflows for Today’s Laboratory</strong></h5><ul><li>Mo, 21.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6514">Registration</a></li></ul><p>Learn how to optimize SPE workflows with best practices for sorbent selection, recovery troubleshooting, and reducing matrix effects in modern analytical laboratories.</p><h5><strong>2. Agilent Technologies: From Crude to Candidate: Scaling Preparative Chromatography with Confidence</strong></h5><ul><li>Mo, 21.9.2026 18:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6498">Registration</a></li></ul><p>Learn how to scale preparative chromatography from crude sample to purified candidate, with practical strategies for method development, fraction collection, and method transfer.</p><h5><strong>3. SCIEX: Extending the power of LC MS/MS: advanced workflows with QTRAP®</strong></h5><ul><li>Tu, 22.9.2026 14:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6518">Registration</a></li></ul><p>Discover how MRM³ and QTRAP workflows provide greater selectivity and lower limits of quantification for LC-MS/MS analysis in complex matrices.</p><h5><strong>4. Technology Networks: Improving Efficiency in Routine PFAS Analysis Using EPA Methods 533 and 1633A</strong></h5><ul><li>Tu, 22.9.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6517">Registration</a></li></ul><p>Explore how automated QC monitoring and the SCIEX novus V55 system support high-throughput PFAS quantitation using EPA Methods 533 and 1633A.</p><h5><strong>5. Phenomenex: Expanding the Evidence: New Data for More Reliable PFAS Analysis</strong></h5><ul><li>We, 23.9.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6522">Registration</a></li></ul><p>Discover how new analytical data and contamination control strategies can improve baseline performance, sensitivity, and reliability in PFAS analysis.</p><h5><strong>6. SCIEX: How is capillary electrophoresis being used to analyze DNA and RNA</strong></h5><ul><li>We, 23.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6521">Registration</a></li></ul><p>Explore how capillary electrophoresis supports DNA and RNA analysis, from plasmid quality assessment to mRNA impurity profiling, viral vector characterization, and oligonucleotide workflows.</p><h5><strong>7. Thermo Fisher Scientific: A novel monodisperse supermacroporous reversed-phase platform for comprehensive nucleic acid analysis across a broad size range</strong></h5><ul><li>We, 23.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6476">Registration</a></li></ul><p>Discover how a novel monodisperse supermacroporous reversed-phase platform enables comprehensive nucleic acid analysis across a broad size range, from short oligonucleotides to mRNA.</p><h5><strong>8. Waters Corporation: The Next Frontier in Nitrosamines Testing: Detection and Risk Assessment in Packaging and IV Infusion Bags</strong></h5><ul><li>We, 23.9.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6520">Registration</a></li></ul><p>Learn how LC-MS/MS supports nitrosamine detection and risk assessment in packaging materials while addressing extractables and leachables challenges in IV infusion bags.</p><h5><strong>9. MDPI: Membrane Technologies for Water and Food Sustainability</strong></h5><ul><li>We, 23.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6561">Registration</a></li></ul><p>Explore membrane technologies for water and food sustainability, international research collaboration, and opportunities within the CYTED Program.</p><h5><strong>10. Agilent Technologies: Unlocking Lab Productivity: Automation Opportunities for LC/MS Laboratories</strong></h5><ul><li>We, 23.9.2026 18:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6495">Registration</a></li></ul><p>Discover how automation can increase productivity in LC/MS laboratories by reducing manual tasks, improving workflow efficiency, and supporting scalable analytical operations.</p><h5><strong>11. Thermo Fisher Scientific: Comparison of biocompatible and inert UHPLC systems for LC-UV quantitation of large RNA</strong></h5><ul><li>Th, 24.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6477">Registration</a></li></ul><p>Learn how the Vanquish Amplify system minimizes metal interactions during LC-UV analysis of large RNA and explore the performance of biocompatible and inert UHPLC systems.</p><h5><strong>12. Agilent Technologies: Next-Generation Pathogen Genomics: The Long-Read Advantage</strong></h5><ul><li>Th, 24.9.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6526">Registration</a></li></ul><p>Explore long-read sequencing and automated target enrichment in pathogen genomics and learn how Agilent SureSelect and Magnis NGS support improved pathogen detection.</p><h5><strong>13. Evosep Biosystems: Advancing Plasma Proteomics</strong></h5><ul><li>Th, 24.9.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6523">Registration</a></li></ul><p>Discover advances in plasma proteomics and learn how high-throughput analytical workflows can accelerate biomarker discovery and cancer research.</p><h5><strong>14. Waters Corporation: Applications of Multi-Angle Light Scattering for Biotherapeutic Characterization</strong></h5><ul><li>Th, 24.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6430">Registration</a></li></ul><p>Learn how multi-angle light scattering (MALS) supports confident characterization of monoclonal antibodies, antibody-drug conjugates, and AAV viral vectors.</p>

Webinars LabRulezLCMS Week 39/2026

Forced degradation analysis of recombinant adeno-associated virus serotype 8 based on analytical anion exchange chromatography coupled to orthogonal characterization

Article

Webinars

Scientists

Scientific article

Interview

Science and research

Video

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Separation Science

Agilent Technologies

Phenomenex

Thermo Fisher Scientific

SCIEX

Waters Corporation

<h5><strong>Key Learning Points:</strong></h5><ul><li>Understand best practices upon opening a new LC Column</li><li>Learn how to clean and regenerate an LC Column</li><li>Find out about additional products and practices that can be used to minimize contamination getting onto LC columns</li></ul><h5><strong>Who Should Attend:</strong></h5><ul><li>Any LC user who would like to ensure that their LC columns are properly cared for to make sure to get most life out of it that is possible.</li></ul><blockquote><p><strong>Presenter:</strong> Genevieve Hodson (Senior Manager, Technical Support &amp; Applications, Phenomenex)</p><p>Genevieve graduated from the University of Texas with a BS in Chemistry located in her home town of Austin Texas. She spent 2 years of her undergraduate performing research in an Organic Chemistry Lab synthesizing intermediates. Out of school she spent 4 years as an Analytical Chemist in the QC and R&amp;D Department of Cerilliant (a Sigma Millipore Company). There she worked with many analytical instruments but became an expert at LC by performing purity analysis, customer specific methods, validations, qc testing and stability studies on a wide range of small molecules including pharmaceuticals, pesticides, explosives and illegal substances. From there she moved to Los Angeles California where she worked at Johnson and Johnson and then a small dietary supplement company. After Genevieve spent a year living abroad in Israel raising her first son, she moved back to LA where she got hired as a Technical Specialist at Phenomenex. At Phenomenex she enjoys continuing to learn about chromatography every day through helping customer with all their chromatography needs!</p></blockquote>

Phenomenex: How to Take Care of Your LC Column

How to Take Care of Your LC Column

Learn about the best practices upon opening your new LC Column, how to clean and regenerate, and additional products and practices...

<p><strong>Measuring scattering samples with UV-VIS-NIR can be challenging for basic instruments. These samples will have diffuse reflectance or transmission and less light hitting your detector.</strong></p><p>In this presentation, we will discuss diffuse reflectance accessories (DRAs) for collecting all light in a measurement as well as Agilent's universal measurement accessory (UMA) for measuring the angular distribution of the reflected light.</p><blockquote><p><strong>Presenter:</strong> Scott Melis, PhD (Application Scientist, Agilent Technologies, Inc.)</p><p>Scott Melis has a PHD in Physics from Georgetown University in Washington, DC and started with Agilent in 2021 as a Molecular Spectroscopy Application Scientist. In his graduate work, Scott studied nanoparticle formation and growth for a variety of applications. Projects that he worked with include developing processes to deposit and characterize semiconducting molecular nano-cocrystals for use in optoelectronic devices as well as controlling polymer nanoparticle size through rapid mixing conditions.</p></blockquote>

Agilent Technologies: Measuring Diffuse Powders and Films With UV-VIS-NIR

Measuring Diffuse Powders and Films With UV-VIS-NIR

We will discuss diffuse reflectance accessories (DRAs) as well as Agilent's universal measurement accessory (UMA).

<div><h4><strong>2026 AQbD Symposium Day 1 - Pharma Small Molecules</strong></h4><p>Staying ahead of regulatory change is a challenge. Evolving guidelines like ICH Q14, Q2(R2), USP &lt;1220&gt;, and the upcoming ICH M4Q(R2) and USP &lt;1225&gt; are reshaping expectations for analytical methods. Risk management and fit-for-purpose principles are now critical for compliance. Join us to explore how Analytical Quality by Design (AQbD) can help you design robust methods, streamline transfers, and meet today’s stringent small molecule and biopharmaceutical requirements.&nbsp;</p><h5><strong>Why Attend:</strong></h5><ul><li>Learn how to apply AQbD principles to the development of robust, risk-based analytical procedures.</li><li>Use DoE tools to identify risks during method transfer and migration.</li><li>Gain practical insights from industry experts on case studies to improve analytical testing reliability.</li></ul><h4><strong>Session 1:</strong></h4><h5><strong>Pharma Small Molecules Presentations Practical elements from ICHQ14, Q2R2 and USP Enhanced Approach » and Practical Tools to Reduce Analytical Risks&nbsp;</strong></h5><ul><li>Gérald de Fontenay, Scientific Director, CEBIPHAR</li></ul><h5><strong>AQbD and DOE Across Pharma Analytical Development</strong></h5><ul><li>Davide Messini, Analytical Development Senior/Scientist, F.I.S. - Fabbrica Italiana Sintetici S.p.A.</li></ul><h5><strong>AQbD Approaches for GLP-1 RA Impurity Profiling</strong></h5><ul><li>Pawel Bigos, Senior Scientist, Waters Corporation</li></ul><blockquote><p><strong>Presenter:</strong> Gérald de Fontenay (Directeur Scientifique et Technique, CEBIPHAR)</p><p>For more than 25 years, Gérald has held key positions within service companies (analytical CROs and CDMOs). He is currently Scientific and Technical Director at CEBIPHAR, where he ensures the highest possible reliability of the results generated both in CEBIPHAR’s laboratories and in those of its clients.</p><p>He provides his expertise in the validation, verification, and transfer of analytical methods to support CEBIPHAR’s project managers and clients, helping to accelerate the implementation of new projects at production sites and to ensure the compliance of reports.</p><p><strong>Presenter:</strong> Davide Messini (Analytical Development Senior/Scientist, F.I.S. - Fabbrica Italiana Sintetici S.p.A.)</p><p>Degree in Chemistry (Padova). He has more than 20 years of experience in analytical chemistry in active pharmaceutical ingredients (API) manufacturing environment. He started in cGMP quality control as a QC analyst and then as R&amp;D analyst in analytical development department. Since 2010 he is responsible for the analytical development related to the manufacturing of API (small molecules) from lab to commercial scale developing and testing all analytical methods suitable for the quality assessment of the substance. Expertise in all common instrumentation used in pharma environment, he ensures the quality of the analytical methods, analytical development strategy, robustness tests and all related cGMP aspects.</p><p><strong>Presenter:</strong> Pawel Bigos (Senior Scientist, Waters Corporation)</p><p>Pawel Bigos is a Senior Scientist at Waters Corporation in the QA/QC Biologics group in Milford, Massachusetts. He holds a Bachelor of Science degree in Chemistry from the University of South Florida. Prior to Waters, Pawel gained valuable experience at Frequency Therapeutics, Novartis, and Symbiotic Research. Since joining Waters in 2022, he has concentrated on biomolecule separations and plays a critical role in providing analytical support in the development, commercialization, and application of Waters innovative products.</p></blockquote></div>

Waters Corporation: 2026 AQbD Symposium - Day 1 - Pharma Small Molecules

2026 AQbD Symposium - Day 1 - Pharma Small Molecules

Learn how AQbD and new ICH/USP guidelines enhance small-molecule method development, risk control, and lifecycle management at the 2026 AQbD Symposium.

2026 AQbD Symposium - Pharma Small Molecules

<div><h4><strong>Unlock the Secrets of Lipid Nanoparticle Characterization</strong></h4><p><strong>Join our exclusive webinar and discover how to overcome the toughest challenges in LNP analysis.</strong></p><p>Are you working with lipid nanoparticles, liposomes, or other lipid-based drug carriers? Whether you’re in discovery, development, QC, or analytical services, or supporting these efforts in a CRO or biotech institute, this session is for you!</p><h4><strong>What you’ll gain:</strong></h4><ul><li><strong>Boost Lab Efficiency: </strong>Learn how automated zeta potential and size measurements for up to 96 samples in a single run free your team to focus on science, not repetitive tasks.</li><li><strong>Master Challenging Samples: </strong>See how Flow Mode preserves sample integrity and delivers precision, even at physiological ionic strength.</li><li><strong>Simplify Your Workflow:</strong> Experience intuitive guided workflows and DYNAMICS Software, fully 21 CFR Part 11–compliant, to ensure data integrity and smooth transition from research to QC.</li></ul><h4><strong>Why attend?</strong></h4><p>Traditional methods struggle with high-salt media, low-charge samples, and regulatory scrutiny. We’ll show you how the DynaPro ZetaStar solves these pain points, delivering accurate, reproducible results with less than 10% RSD, full compliance, and automation that scales with your needs. Plus, discover how DYNAMICS Software and DYNAMICS Touch make complex analyses simple, reliable, and fast, even from microliter volumes.</p><p><strong>Don’t miss this chance to transform your LNP characterization process.</strong></p><p><i>Reserve your spot today and take the first step toward faster, more reliable insights.</i></p><blockquote><p><strong>Presenter:</strong> Richard Chung (Lab Analytics Product Manager, Waters | Wyatt Technology)</p><p>Since joining Wyatt in 2016, he has held key roles, including Application Scientist and Customer Support Manager, where he worked closely with researchers to solve complex analytical challenges. Now, as a Product Manager, Richard bridges the gap between scientists and better instruments - gathering insights from the field and collaborating with internal research teams to develop cutting-edge solutions that empower laboratories worldwide.</p></blockquote></div>

Waters Corporation: Automation, Speed, and Simplicity for Total Lipid Nanoparticle Characterization

Automation, Speed, and Simplicity for Total Lipid Nanoparticle Characterization

Join our exclusive webinar and discover how to overcome the toughest challenges in LNP analysis.

Total Lipid Nanoparticle Characterization

<h4><strong>How about a 30 minute coffee break along with a taste of Empower?</strong></h4><h4><strong>Here you go!</strong></h4><h5><strong>Short session, big results</strong></h5><p>Learn quick, impactful tricks to make your Empower Software reports smarter and more insightful. Whether you’re aiming for compliance or clarity, these practical hacks will help you save time and elevate your reporting. A short session – for big results.</p><h5><strong>What will you learn?</strong></h5><ul><li>Save time instantly – Discover techniques that dramatically reduce reporting effort</li><li>Boost report quality – Create clear reports that are more professional and easier to understand</li><li>Stay compliant with ease – Integrate regulatory requirements without stress</li></ul><p><i>Reserve your spot today and make your Empower Software reports shine!</i></p><blockquote><p><strong>Presenter: </strong>Ralf Schröder (Informatics Market Development Manager)</p><p><strong>Presenter:&nbsp;</strong>Carsten Fischer (Informatics Product Marketing, EMEA)</p><p><strong>Presenter:&nbsp;</strong>Ilse Hoes (Solutions Manager, Informatics at Waters Europe)</p></blockquote>

Waters Corporation: Informatics series #30 Empower Reports - Simple & Smart

Informatics series #30 Empower Reports - Simple & Smart

Learn quick, impactful tricks to make your Empower Software reports smarter and more insightful. 

Informatics series #30 Empower Reports 

<p><strong>Accurate mass fundamentals breaks down the barriers of complexity, demystifies misconceptions, and provides helpful tips on how to improve your data quality.</strong></p><p>Whether you already use accurate mass spectrometry and are looking to grow your knowledge or are currently working with nominal mass spectrometry and are thinking about making the switch, this webinar series will show you how accurate mass can simplify your workflow, clarify your data, and give you greater confidence in every result.</p><p>Sign up today to discover the practical advantages of accurate mass spectrometry.</p><h4><strong>Session 2: From theory to practical workflows</strong></h4><ul><li>See how accurate mass integrates into everyday workflows</li><li>Confidently interpret HRMS data</li><li>Build robust methods with automation to simplify complex analyses</li></ul>

Accurate mass fundamentals - From theory to practical workflows

How accurate mass spectrometry works in real workflows. Session 2 focuses on HRMS data interpretation, method robustness, and automation for complex analyses.

Accurate mass fundamentals - From theory to practice

<div><h4><strong>2026 AQbD Symposium Day 2 - Biopharmaceutical</strong></h4><p>Staying ahead of regulatory change is a challenge. Evolving guidelines like ICH Q14, Q2(R2), USP &lt;1220&gt;, and the upcoming ICH M4Q(R2) and USP &lt;1225&gt; are reshaping expectations for analytical methods. Risk management and fit-for-purpose principles are now critical for compliance. Join us to explore how Analytical Quality by Design (AQbD) can help you design robust methods, streamline transfers, and meet today’s stringent small molecule and biopharmaceutical requirements.&nbsp;</p><h5><strong>Why Attend:</strong></h5><ul><li>Learn how to apply AQbD principles to the development of robust, risk-based analytical procedures.</li><li>Use DoE tools to identify risks during method transfer and migration.</li><li>Gain practical insights from industry experts on case studies to improve analytical testing reliability.</li></ul><h4>Agenda</h4><h5><strong>Incorporating Analytical Quality by Design in Early Phase Development of mAbs and ADCs&nbsp;</strong></h5><ul><li>Mark Eggink, Principal Scientist, Analytical Development and Quality Control, Byondis</li></ul><h5><strong>Application of Analytical Quality by Design Principles to the Analysis of Nucleic Acids using an Innovative Dual Gradient Approach</strong></h5><ul><li>Ricardo Gonçalves, Senior Analytical Scientist, Hovione</li></ul><h5><strong>Leveraging AQbD Principles for Efficient Development of a Targeted Assay Method for Routine Monitoring of Mannose-5 Glycans Using Fluorescence Detection</strong></h5><ul><li>Pawel Bigos, Senior Scientist, Waters Corporation</li></ul><blockquote><p><strong>Presenter:</strong> Mark Eggink, Ph.D. (Principal Scientist, Analytical Development and Quality Control, Byondis)</p><p>Mark Eggink, PhD, is Principal Scientist at Byondis, where he is responsible for analytical support for process development, method development and validation, batch release and stability testing of monoclonal antibodies and antibody drug conjugates.</p><p><strong>Presenter: </strong>Ricardo Gonçalves (Senior Analytical Scientist, Hovione)</p><p><strong>Presenter: </strong>Udayabagya (Bud) Halim (Sr. Marketing Analyst, Waters Corporation)</p><p>Bud Halimis a senior marketing analyst at Waters | Wyatt Technology with a PhD in physical chemistry from UCLA. He began his career teaching biochemistry and chemistry and contributing to laboratory manuals before transitioning into the scientific instrumentation industry as an applications scientist. At Waters, he supports researchers in the characterization of peptides, biologics, lipid nanoparticles (LNPs), and viral vectors.</p></blockquote></div>

Waters Corporation: 2026 AQbD Symposium - Day 2 - Biopharmaceutical

2026 AQbD Symposium - Day 2 - Biopharmaceutical

Join Day 2 of the 2026 AQbD Symposium to learn how AQbD enables compliant, risk-based biopharmaceutical analytics under evolving ICH and USP guidelines.

2026 AQbD Symposium - Biopharmaceutical

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Preparative LC is an indispensable technique for compound purification across many industries. This webinar delivers practical, ready-to-use tips—from smart column selection to smooth scale-up from analytical to preparative workflows—helping you improve yield, purity, and throughput right away.</strong></p><h4><strong>Who should view it?</strong></h4><p>Laboratory technicians, researchers, and scientists seeking to better understand how to facilitate the analytical-to-preparative chromatography workflow.</p><h4><strong>By attending this webinar, you will:</strong></h4><ul><li>Gain tips for selecting columns and systems in preparative chromatography</li><li>Discover best practices and considerations for scale-up</li><li>Learn methods to streamline preparative workflows</li></ul><blockquote><p><strong>Presenter: </strong>Daiki Fujimura (Assistant Manager, Labo Consumables, Shimadzu Corporation)</p><p>Daiki Fujimura majored in analytical chemistry at Meiji University in Tokyo, Japan, and joined Shimadzu Corporation in 2015. He has over 10 years of experience as an application chemist specializing in liquid chromatography.</p></blockquote></div></div></div>

SeparationScience: Fast Wins: Preparative LC Tips for Beginners Ready to Use Tomorrow

Fast Wins: Preparative LC Tips for Beginners Ready to Use Tomorrow

Discover how preparative LC can streamline your analytical workflows for compound purification.

Preparative LC Tips for Beginners Ready to Use Tomorrow

<div><h4><strong>Transform Lab Automation Connectivity</strong></h4><p>Join our exclusive webinar to discover how the <strong>Waters OneLab™ Secured Deployment Solution</strong> takes you from box to bench.</p><p>Your new <strong>Waters™ Andrew+ Robot</strong> has arrived, and you’re ready to automate right away with no IT support required. With intuitive technology and clear guidance, you’ll simplify setup and be on your path to impact in no time.</p><p>When you’re ready to connect OneLab™ Software with <strong>Empower™, MassLynx™, or waters_connect™</strong>, simply include our IT installation documentation with your request. Your IT partner will be ready to make the connection.</p><p>It’s simple, secure, Windows®-based, and designed to isolate the network connection from Andrew+ Robot, now you can automate with confidence.</p><h5><strong>Learn how OneLab Secured Deployment Solution architecture:</strong></h5><ul><li>Enables cybersecurity and delivers enterprise-ready performance</li><li>Accelerates IT implementation with ready-to-use deployment.</li><li>Supports 21 CFR Part 11 and GxP compliance for regulated workflows.</li><li>Integrates seamlessly with waters_connect, Empower, and MassLynx to optimize productivity.</li></ul><h5><strong>Who should attend?</strong></h5><p>If you work in Pharma or Biopharma as an IT Manager, R&amp;D Scientist, or QA/QC Scientist, this exclusive webinar is designed for you.</p><p><i><strong>Don't miss it.</strong></i></p><blockquote><p><strong>Presenter:</strong> Guillaume Mignard (OneLab Product Marketing Manager, Waters Corporation)</p><p>Guillaume Mignard is Product Designer and Product Owner of OneLab™ Software at Waters Corporation.</p><p>Since joining Waters in 2017, he has led the strategic direction, design, and implementation of OneLab™ Software, a cloud-based platform making lab automation accessible to scientists worldwide.</p><p>Guillaume began his career as a UX/UI designer for business software, pioneering user-centric design when it was still emerging beyond web marketing.</p></blockquote></div>

Waters Corporation: Introducing the Waters OneLab Secure Deployment Solution

Introducing the Waters OneLab Secure Deployment Solution

Join our exclusive webinar to discover how the Waters OneLab™ Secured Deployment Solution takes you from box to bench.

Introducing Waters OneLab Secure Deployment Solution

<div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><p><strong>Take your Chromeleon Instrument Methods to the next level with this focused and practical session. This webinar is specifically designed for Thermo Scientific Chromeleon CDS users, who want to enhance their current skills and gain a better understanding of how to control instrument actions and apply dynamic sequence logic.</strong></p><h4><strong>Topics covered include:</strong></h4><ul><li><strong>Script editor overview:</strong> Understand the basics of writing and editing custom scripts</li><li><strong>Conditional statements:</strong> Learn how to use logic to make conditional decisions during runs and sequences</li><li><strong>Information logging:</strong> Record key instrument and method events in real time for extended audit trail coverage</li><li><strong>Custom sequence variables: </strong>Control sequence and instrument behavior and with user-defined fields to enrich meta data capture</li><li><strong>User-defined programs:</strong> Customize injection actions to support complex workflows</li><li><strong>Automated startup and shutdown: </strong>Create routines to prepare instruments for operation or safely power them down</li></ul><h4><strong>Why Attend:</strong></h4><p>Join this webinar to gain practical skills and expert tips for using Chromeleon CDS more effectively. Whether you’re new or experienced, you’ll learn how to streamline workflows and enhance your analytical instrument methods.</p><p><strong>Cannot attend the live broadcast?&nbsp;</strong></p><p><i>Please register anyway, and we will automatically send you the link to the recording.</i></p><blockquote><p><strong>Presenter: </strong>Peter Zipfell (Product Marketing Manager, Thermo Fisher Scientific)</p></blockquote></div></div></div>

Thermo Fisher Scientific: Get more from your Chromeleon Instrument Methods

Get more from your Chromeleon Instrument Methods

Join this webinar to gain practical skills and expert tips for using Chromeleon CDS more effectively.