At UC San Diego, researchers are using patient-derived brain organoids and spaceflight to explore whether aging-associated biology can be accelerated in orbit. With advanced proteomics enabled by the Thermo Scientific Orbitrap Astral Mass Spectrometer (MS), the team is gaining deeper insight into complex brain biology and new possibilities for studying neurodegenerative disease.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Neuroscience_Takes_Flight_How_Collaboration_Spaceflight_and_Orbitrap_Astral_MS_Are_Opening_a_New_Window_into_Brain_Aging_6b56e04145.webp" alt="Thermo Fisher Scientific: Neuroscience Takes Flight: How Collaboration, Spaceflight, and Orbitrap Astral MS Are Opening a New Window into Brain Aging" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Neuroscience_Takes_Flight_How_Collaboration_Spaceflight_and_Orbitrap_Astral_MS_Are_Opening_a_New_Window_into_Brain_Aging_6b56e04145.webp 245w," sizes="100vw" width="1024" height="512"><h3>Introduction</h3>Neurodegenerative diseases remain among the most difficult conditions to study. Researchers cannot easily or safely biopsy living brain tissue, and even sophisticated disease models can take years to reveal meaningful biological change. At UC San Diego, Drs. Aline Martins and Alysson Muotri are taking a different approach: creating patient-derived brain organoids from skin cells and sending them to space to explore whether low Earth orbit can accelerate aging-associated biology. Preliminary data suggest that 30 days in space may compress roughly 10 years of aging biology into a much shorter experimental window, opening the door to a faster path for understanding neurodegeneration and evaluating new therapeutic ideas.<h3>A study design built around biology</h3>The real power of this work begins with the study design. Rather than relying on generalized models, the researchers begin with skin cells from patients and generate 3D mini-brain organoids that can model diseases such as Alzheimer’s while preserving critical patient context. That gives the team a more human-relevant system for studying how aging and disease unfold over time. Spaceflight adds a second dimension: a research environment that is exceptionally difficult to reproduce on Earth, but one that may help reveal the molecular and cellular drivers of neurodegeneration faster than conventional studies allow. The Integrated Space Stem Cell Orbital Research (ISSCOR) Center at UC San Diego have begun to explore this broader approach to study how space-related stressors influence brain aging and cognitive decline, with potential relevance to diseases such as Alzheimer’s and dementia. Once those organoids return to Earth, the next challenge is extracting as much insight as possible from every sample.<h3>Enabling deeper insight from limited samples</h3>Brain organoids are inherently heterogeneous, with multiple cell subtypes that may respond differently to aging and environmental stress.To extract deeper biological insight from the organoid samples, the researchers describe the<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/836"> Orbitrap Astral MS </a>as central to their investigation. They highlight that the high sensitivity required for single-cell proteomics is essential for revealing how the space environment affects distinct cell populations and the Orbitrap Astral MS helps unlock deeper biological insight.That distinction is important: the value of the Orbitrap Astral MS analytical workflow is not simply generating more data but importantly helping the team resolve more of the biology within a complex model.<h3>How Orbitrap Astral MS helps push biology further</h3>At Thermo Fisher Scientific, we work alongside researchers pursuing bold scientific questions by developing technologies that help them see deeper into complex biology.Aline describes Orbitrap Astral MS as a major advance for the sensitivity and resolution this research requires. Its synchronized data acquisition capabilities and parallel ion processing across dual high-resolution accurate-mass analyzers with maximized instrument utilization help deliver deeper coverage, higher sensitivity, faster throughput, and accurate, precise quantitation across demanding biological workflows.For studies like this one, those capabilities help researchers get more from limited sample material, uncover subtle disease-relevant changes, and translate an inventive experimental design into deeper biological insight, faster.<h3>Looking ahead</h3>The power of this research lies in the convergence of ideas. Patient-derived brain organoids offer a human-relevant model of disease. Spaceflight may serve as an aging accelerator. Advanced proteomics helps researchers understand what complex biological models are revealing with greater depth and clarity, while single-cell proteomics unlocks a view into cell-specific changes that can drive disease biology. Together, this approach could give scientists a faster and more informative way to study late-onset diseases such as Alzheimer’s and dementia. This initiative between UC San Diego and Thermo Fisher Scientific shows how collaborations across the scientific community can open new doors in neuroscience and accelerate discovery in ways that matter. As researchers continue to push the boundaries of what is possible, studies like this one point to a future where deeper biological insight can be reached faster and with greater potential to improve human health.<h3>Learn more</h3><ul><li>Listen to the <a target="_blank" rel="noopener noreferrer" href="https://corporate.thermofisher.com/us/en/index/newsroom/Our-stories/Brains-in-space.html">interview with Dr. Aline Martins</a> for more on the scientific vision behind this research and its implications for brain aging and neurodegenerative disease.</li><li>Learn more about <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/mass-spectrometry/proteomics-mass-spectrometry/single-cell-proteomics.html">Thermo Fisher Scientific single-cell proteomics solutions</a> and how they help researchers gain deeper insight from limited and complex samples.</li><li>Explore the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/836">Thermo Scientific Orbitrap Astral MS</a> and see how it helps researchers achieve deeper biological insight with faster throughput, higher sensitivity, and accurate, precise quantitation across advanced workflows.</li></ul><blockquote>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#BrainOrganoids #SpaceBiology #Neurodegeneration #OrbitrapAstralMS</blockquote>

Neuroscience Takes Flight: How Collaboration, Spaceflight, and Orbitrap Astral MS Are Opening a New Window into Brain Aging

Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 29th September 2026? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you technical note by KNAUER, application note by Shimadzu and posters by Thermo Fisher Scientific / HPLC Symposium and Waters Corporation / AOAC!<h3>1. KNAUER: Efficient separation of di(2-ethylhexyl) phthalate (DEHP) from oil matrices using GPC</h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/VTN_00_XX_knauer_applichrom_gpc_f1d7f1a236.pdf">Full PDF for download</a></li></ul>Phthalates are chemical compounds primarily used as plasticizers in polymers to enhance the flexibility and elasticity of materials such as polyvinyl chloride (PVC) [1]. Since plasticizers are not covalently bound to the polymer chains, they have the potential to leach into the contacting media and contribute to contamination [2]. With the widespread and increasing use of plastic materials, the risk of phthalate release and human exposure continues to rise. As a result, and due to their potentially harmful effects on human health, phthalates have attracted growing scientific and regulatory attention in recent years [1]. Oil-rich food products can leach lipophilic phthalates from their packaging [3]. Throughout the production and packaging process, polymeric components such as tubing, containers, and caps may serve as potential sources of contamination. For the analysis of phthalates in such oil matrices, sample cleanup is an essential step. Gel permeation chromatography (GPC), based on sizeexclusion principles, is widely applied as an effective cleanup technique prior to subsequent analytical determination.<h4>MATERIALS &amp; METHODS</h4>The samples were dissolved in the eluent mixture and filtered through a 0.45 µm PTFE filter prior to analysis. For both olive oil and canola oil, an additional sample spiked with DEHP was prepared and likewise filtered before analysis. Chromatographic analysis was performed using an isocratic method with an eluent composition of ethyl acetate/heptane (50:50 v/v) at a flow rate of 1.0 mL/min. Detection was carried out by UV absorbance at 254 nm. The injection volume was 8 µL using a full-loop injection mode. The column temperature was maintained at 25°C. Separation was achieved on an AppliChrom® OleoSep column (10 µm, 300 × 8 mm). The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1630">AZURA® Semi Preparative GPC System</a> was used.<h4>CONCLUSION</h4>GPC sample preparation is an effective approach for separating phthalates from high-molecular-weight matrices such as edible oils. In this study, the successful separation of di(2-ethylhexyl) phthalate (DEHP) from three different oil samples was demonstrated. Based on these results, it can be assumed that other phthalates with lower molecular weights (&lt; 390 Da) can also be effectively separated under same conditions. The KNAUER AZURA® GPC semi preparative system (Fig. 4) in combination with the AppliChrom® OleoSep GPC column provides a robust and efficient setup for sample preparation in phthalate analysis, offering rapid separation, high resolution, and minimal solvent consumption due to the short analysis time.<h3>2. Shimadzu: Analysis of Chloride and Sulfate Ions in Bioethanol Using the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=1&amp;search=Nexera+IC">Nexera IC Ion Chromatograph</a></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_01_01211_en_55cbf3e64f.pdf">Full PDF for download</a></li></ul><h5>User Benefits</h5><ul><li>Analysis of chloride and sulfate ions in fuel ethanol can be conducted in accordance with ASTM D7319-221) .</li><li>Accurate quantitative determination, exhibiting excellent linearity and repeatability, can be achieved at concentration levels significantly below the limits specified by the ASTM criteria.</li></ul>First-generation bioethanol produced from raw materials such as corn and sugarcane has been utilized to achieve carbon neutrality. However, research and development for second-generation bioethanol produced from non-food, cellulose-based raw materials is also underway to avoid competition with food crops. In Japan, eight companies, including Toyota Motor Corporation, have formed the “Research Association of Biomass Innovation for Next Generation Automobile Fuels” (raBit) to advance research on next-generation bioethanol technologies. Shimadzu participates as a supporting member and promotes research and development through analytical technology cooperation.&nbsp;It is known that the presence of chloride and sulfate ions in fuel ethanol can form engine residue, leading to reduced engine performance. ASTM D4806-252) specifies fuel ethanol quality as criterion of chloride ion must not exceed 6.7 mg/kg and that of sulfate ion must not exceed 4 mg/kg. ASTM D7319-22 includes test methods for chloride and sulfate ions in fuel ethanol using ion chromatography.&nbsp;In this application, we present an example of the analysis of chloride and sulfate ions in bioethanol using the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=1&amp;search=Nexera+IC">Nexera IC</a> in accordance with ASTM D7319-22.<h4>Conclusion</h4>Chloride and sulfate ions in bioethanol were determined using a Nexera IC system in accordance with ASTM D7319-22. The method offers high sensitivity, linearity, and repeatability, enabling reliable quantification at concentrations well below ASTM-specified limits, thus supporting effective quality control and regulatory compliance of fuel ethanol.<h3>3. Thermo Fisher Scientific / HPLC Symposium: LC-MS analysis of intact and subunit-level mAb enabled by a novel monodisperse supermacroporous reversed-phase platform</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/po_004763_ccs_surepac_protein_reverse_phase_mabs_separation_po004763_na_en_56199ec50d.pdf">Full PDF for download</a></li></ul>Monoclonal antibodies (mAbs) are structurally complex biotherapeutics that require multi-level analytical characterization to ensure product quality, safety, and efficacy. LC-MS analysis is routinely applied at the intact protein and subunit levels to assess molecular mass, heterogeneity, and structural integrity. Enzymatic subunit generation, such as IdeS digestion, enables targeted domain-level characterization while reducing analytical complexity compared to full peptide mapping. Achieving high-performance reversed-phase separations across intact and subunit-level workflows remains challenging, as chromatographic columns optimized for intact proteins often compromise performance of smaller subunits. Consequently, multiple columns are required to support comprehensive mAb characterization.&nbsp;In this study, we evaluate a reversed-phase separation column based on a novel 2.5 μm monodisperse supermacroporous (SMP) polymeric stationary phase for unified LC-MS analysis of monoclonal antibodies under intact, reduced, and IdeSdigested conditions. The SMP resin’s uniform particle size and highly accessible pore structure enable efficient separation of both small and large analytes, including intact mAbs, reduced subunits (LC and HC), and IdeS-generated fragments such as scFc and F(ab′)₂. Using the SurePac Protein RP MDi column, baseline separation of these species was achieved within a 10- minute gradient, providing a fast, all-in-one LC-MS approach for mAb variant characterization.<h4>Materials and methods</h4><h5>Instruments&nbsp;</h5><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/744">Thermo Scientific Vanquish Horizon UHPLC system</a>; <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/401">Thermo Scientific Orbitrap Exploris 480 mass spectrometer</a> with Thermo Scientific OptaMax NG ion source.&nbsp;<h5>Data analysis&nbsp;</h5>The UHPLC system with mass spectrometer were operated with <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1758">Thermo Scientific Xcalibur 4.7 software</a>. Full MS spectra of intact mAbs and mAb fragments were analyzed using Thermo Scientific Freestyle 1.8 and BioPharma Finder 5.4 software that utilizes the ReSpect and Xtract algorithms for molecular mass determination.<h4>Conclusions&nbsp;</h4><ul><li>A SurePac Protein RP column enabled a rapid (10 min) separation of mAb LC, HC, scFc, and F(ab′)₂ fragments, with major proteoforms identified by mass agreement.&nbsp;</li><li>The SurePac Protein RP column supports comprehensive intact and subunit-level mAb characterization in a single workflow, with strong separation performance across mAb fragments.</li></ul><h3>4. Waters Corporation / AOAC: IMPROVED PURIFICATION OUTCOMES FOR PROBLEMATIC COMPOUNDS USING AN INERT COLUMN WITH POLAR SORBENT</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/720009616_AOAC_f65ea1b771.pdf">Full PDF for download</a></li></ul><div><div><section><div><div><div><div><div><div>Whether the goal is to obtain enough intermediate for the next step in a synthetic scheme, to polish a final product, or to create a suitable standard for compound identification, preparative liquid chromatography remains a primary technique for isolating compounds from complex mixtures. Recovering the target compound at the desired purity and yield in the least amount of time is of utmost importance.&nbsp;Polar targets that do not retain, or “sticky” compounds that seemingly disappear on the column are two groups that many consider to be ’problematic’ in purification. “Sticky” compounds, also known as non-specific adsorbers (NSAs), are metal-sensitive targets what can adsorb to positively charged metal surfaces in the LC system flow path and column, making them difficult to detect and collect effectively. Although other methods, such as column pre-conditioning, can be implemented for isolating compounds known to be interactive, this option can be time-consuming and lead to sample loss and excessive solvent waste.&nbsp;Although lab scale purifications in which tens to hundreds of milligrams of target compound are isolated from crude mixtures are still performed routinely, the trend toward smaller scale purification is becoming more prevalent. Laboratories are increasingly opting to isolate only a few milligrams of target compound for preliminary studies. Successful target candidates are then isolated in greater amounts to satisfy ensuing experiments. Whether the objective is to isolate a small amount of target compound for exploratory studies, or to purify greater amounts for their use as reference standards, a column which can resolve eluting impurities efficiently is required.&nbsp;Echinacea is an herbaceous flowering plant in the daisy family1,2 and is one of the most important medical herbs widely used to treat the common cold and other infectious diseases.3 One of the most abundant compounds in echinacea is chicoric acid (Figure 1), a phenylpropanoid and caffeic acid derivative.4,5 In this scale-up study, chicoric acid, a suspected “sticky” target polar compound was isolated from a complex echinacea tea extract using two inert XSelect HSS T3 MaxPeak Premier OBD Columns with different particle sizes and dimensions (3.5 μm 10 x 100 mm and 5 μm 10 x 150 mm). The MaxPeak Premier OBD preparative HPLC columns are considered ’inert’ because they are enabled with Waters High Performance Surface (HPS) Technology. The chicoric acid isolated using the 3.5 μm column was of equivalent UV purity to the product isolated using the 5 μm column, with a 34% savings in run time. Smaller particle preparative isolations using columns with inert hardware are a practical option for those laboratories where reduced amounts of target are needed for projects conducted on accelerated timelines.<h4>METHODS</h4><ul><li>Analytical Columns and flow rate: ACQUITY Premier HSS T3 and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1952">ACQUITY UPLC HSS T3 Columns</a>; 1.8 μm, 2.1x50 mm; 0.35 mL/min&nbsp;</li><li>Prep Columns and flow rate: XSelect HSS T3 OBD Prep Column and XSelect Premier HSS T3 OBD Prep (custom) Columns, 5 μm, 10x150 mm; XSelect Premier HSS T3 OBD Prep Column, 3.5 μm, 10x100 mm; 5.4 mL/min</li></ul><h5>Instrumentation&nbsp;</h5><ul><li>Analytical: <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/198">ACQUITY UPLC H-Class System</a>; Quaternary Solvent Manager, Sample Manager FTN-H, Column Manager, TUV Detector, <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1543">ACQUITY QDa Detector&nbsp;</a></li><li>Prep: Waters AutoPurification System; 2545 Binary Gradient Module, 2767 Sample Manager, System Fluidics Organizer, 2998 Photodiode Array Detector</li></ul><h4>CONCLUSIONS&nbsp;</h4><ul><li>Chicoric acid was analyzed and isolated using analytical and preparative MaxPeak Premier HSS T3 Columns with inert surfaces, which increased the peak area and height for improved detection and collection.&nbsp;</li><li>Chicoric acid was successfully isolated using 3.5 and 5 μm XSelect Premier HSS T3 OBD Prep Columns and fraction pool analysis showed equivalent UV purity, which suggests the viability of incorporating small particle preparative chromatography into the purification workflow.&nbsp;</li><li>3.5 μm preparative columns improve purification process efficiency and promote sustainability by reducing method run time, solvent usage, and fraction lyophilization time.&nbsp;</li><li>Inert MaxPeak Premier column hardware, OBD Technology, and small particle preparative columns are well-suited for the demands of the purification laboratory when results must be generated efficiently to satisfy accelerated production timelines</li></ul></div></div></div></div></div></div></section></div></div>

News from LabRulezLCMS Library - Week 40, 2026

Pressurized Liquid Extraction: Principle, Method, and Workflow

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Agilent Technologies

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The importance of safety and quality testing of cannabis and hemp is paramount in order to satisfy both consumers’ need and regulatory requirements.
The implementation of the testing protocols requires considerable time and substantial technical expertise. To reduce the time and effort needed to create optimized end-to-end workflows, we will show how eMethods establish and sustain reliable and efficient analytical protocols faster and easier, leading to increased productivity and profitability. A suite of eMethods will be presented for potency, pesticide residue, mycotoxins, heavy metals, and residual solvents testing. Beside the complete instrumental and data analysis methods, information on sample preparation and best practices are also provided along with a comprehensive list of all the essential consumables and supply needed for the application.
Scientist performing these analyses, laboratory management and investors planning to set up cannabis testing laboratories will benefit from the conveyed information. 
<blockquote>
Presenter: Elizabeth Almasi (Applications Program Manager, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Elizabeth Almasi is the Application Program Manager in the Mass Spectrometry division at Agilent technologies in Santa Clara. Ms. Almasi has decades long experience both in application development and instrumentation design. Harnessing her extensive expertise in efficient application development under the strictest QC requirements and pairing it with the exceptional technical capabilities of Agilent’s analytical instrumentation, her latest project is eMethod development for cannabis testing.
</blockquote>

Agilent Technologies: Ready-to-run eMethods Make Complex Cannabis Testing Simple

Ready-to-run eMethods Make Complex Cannabis Testing Simple

Within the petrochemical industry, analytical experiments take place throughout the entire production process, from exploration to final product, during which massive amounts of data are generated.
The biggest challenge is to collect and connect all this generated data in accordance with requirements that are very specific for this industry, where analytical workflows are centered around a variety of instruments, a wide range of people use the laboratory software and keeping the plant running without interruption is of utmost importance.
This webinar discusses a new software solution tailored to the petrochemical industry, focused on instrument-centric workflow support.
<h3>In this webinar, you will:</h3>
<ul>
<li>Hear from experts how to leverage a a chromatography data system (CDS) for laboratories in the (petro)chemical industry to streamline instrument-centric workflows </li>
<li>Learn how to leverage a CDS to streamline operations for all users regardless of experience</li>
<li>Discover the latest features in Thermo Scientific™ Chromeleon™ CDS to leverage as a petrochemical software solution for chromatography and mass spectrometry instruments</li>
</ul>
<blockquote>
Presenter: Josh Howard (Customer Solutions Engineer, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Presenter: Greg Whitaker (Software Product Manager (Enterprise Chromeleon), Thermo Fisher Scientific)
</blockquote>

Pixabay/Ralf Vetterle: Discover CDS Solutions For (Petro) Chemical Workflows

Discover CDS Solutions For (Petro)Chemical Workflows

Join Agilent for part 2 of our virtual food summit! Our scientists will continue sharing their work and expertise on the latest in food analyses. Tune in to hear us discuss topics such as mycotoxins, extractables and leachables, PFAS, and food and beverage analysis with FTIR and more. This virtual food summit will provide insight on the latest trends and issues in the industry and how Agilent has developed systems and applications to meet the latest requirements. This event is important to analysts, technicians and managers of food analysis laboratories, those working on method development, and researchers and scientists working on food authenticity and food fraud.
<h3>Topics to be discussed:</h3>
<ul>
<li>Routine and Robust Analysis of Mycotoxins in Food Matrices Using the Innovative Ultivo Triple Quad LC/MS </li>
<li>Optimized Per- and Polyfluoroalkyl Substance (PFAS) Analysis in Meat, Dairy, Seafood &amp; Food Packaging </li>
<li>Analysis of Food Contact Material Using GC/MS and LC/MS </li>
<li>Optimized Lipid Removal for the Analysis of 16 Heavy Polycyclic Aromatic Hydrocarbon Residues in Pumpkin Seed Oil Using the 7010B Triple Quadrupole GC/MS </li>
<li>Elemental Analysis after Microwave Digestion of Various Food Products </li>
<li>FTIR and Fluorescence Spectroscopic Analysis in the Food and Beverage Industry</li>
</ul>
<h3>Agenda</h3>
<h5>11:00AM – 11:05AM - Welcome and Introduction</h5>
Presenter: Tarun Anumol, Director of Global Food &amp; Environmental Markets
<h5>11:05AM—11:30AM - Routine and Robust Analysis of Mycotoxins in Food Matrices Using the Innovative Ultivo Triple Quad LC/MS</h5>
Presenter: Kyle Covert, LC/MS Application Scientist
<h5>11:30AM -11:55AM - Finger Lickin’ Bad? Optimized Per- and Polyfluoroalkyl Substance (PFAS) Analysis in Meat, Dairy, Seafood &amp; Food Packaging</h5>
Presenter: Tarun Anumol, Director of Global Food and Environmental Markets
<h5>11:55AM – 12:20PM - Analysis of Food Contact Material using GC/MS and LC/MS</h5>
Presenter: David Weil, LC/MS Application Scientist and Matt Curtis, GC/MS Application Scientist
<h5>12:20PM – 12:45PM - Optimized Lipid Removal for the Analysis of 16 Heavy Polycyclic Aromatic Hydrocarbon Residues in Pumpkin Seed Oil using the 7010B Triple Quadrupole GC/MS</h5>
Presenter: Melissa Churley, GC/MS Application Scientist
<h5>12:45AM – 1:20PM - Elemental Analysis after Microwave Digestion of Various Food products</h5>
Presenter: Jenny Nelson, Greg Gilleland, and Ana Garcia, Agilent Atomic Application Scientists
<h5>1:20PM – 1:45PM - FTIR and Fluorescence Spectroscopic Analysis in the Food and Beverage Industry</h5>
Presenters: Yanqia Wang, Agilent FTIR Application Scientist
<h5>1:45-2:00 PM - Wrap-up and Final questions</h5>

Agilent Technologies: Agilent Virtual Food Summit - Part II Food for Thought

Agilent Virtual Food Summit - Part II Food for Thought

Nitrosamine (genotoxic) impurities have been found in some angiotensin II receptor blocker (ARB) medicines, such as valsartan, and more recently in histamine-2 receptor blocker medicines, such as ranitidine, drawing close scrutiny from FDA, the European Medicines Agency (EMA) and other regulatory bodies leading to product recalls.
Gas chromatography–mass spectrometry (GC-MS) has typically been the detection technique of choice; however, not all nitrosamines can be analyzed this way. As the number of known nitrosamines requiring trace level quantitation increases, the greater the need for robust, sensitive, and high-throughput assays to provide a cost-sensitive approach of a single analysis capable of accurately measuring all compounds. The use of liquid chromatography with high-resolution MS (LC-HRMS) allows low level detection and high confidence of a wider range of nitrosamine impurities.
<h3>Session breakdown:</h3>
<h5>11:00 CEST, 10 minutes + Q &amp; A</h5>
Introduction to impurity analysis challenges and regulatory requirements in Europe
Presenter: Jon Bardsley,Pharmaceutical Marketing Manager , Thermo Fisher Scientific
<h5>11:20 CEST, 20 minutes + Q &amp; A</h5>
Chromatography and Mass Spectrometry software for GMP impurity testing
Presenter: Darren Barrington-Light, Software Product Marketing Manager, Thermo Fisher Scientific
This session will give an overview of the current landscape of impurity testing in general and with a focus on nitrosamines and the European regulations. We will then cover our software, Chromeleon for Mass Spectrometry with an overview and focus on data integrity and compliance. You will have a chance to ask questions to our specialists on these topics.
<h3>Key Learning Objectives:</h3>
<ul>
<li>Why is the analysis of genotoxic impurities important?</li>
<li>Method development considerations for trace level impurities</li>
<li>What are the current regulations in Europe?</li>
<li>The role of compliance in data software with mass spectrometry</li>
</ul>
<blockquote>
Presenter: Darren Barrington-Light (Senior Product Marketing Manager, Enterprise Chromatography Data Systems, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Having worked in Chromatography throughout his careerin the fieldsof analytical chemistry, chromatography hardware and computer software,specifically Chromatography Data Systems,for over25years, Darren has a unique understanding of the requirements of organizations that rely on chromatography data to manage their day to day operations. As capabilities have advanced, Darren has worked with clients across multiple industries to show them how Thermo Scientific Chromeleon CDS software can help them to improve their day to day operations and drive fast, informed decisions.
</blockquote>
<blockquote>
Presenter: Jon Bardsley (Pharma &amp; BioPharma Manager, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Jon Bardsley has over a decade of experience of small-molecule pharmaceutical DMPK and regulated bioanalytical studies within with large Pharmaceutical environments. His passion for development of robust and accurate analytical methods for high-throughput studies has seen him also gain experience in contract research organizations. Jon sits on the ReidBioAnalyticalcommittee of the Chromatography Society and is a subject matter expert in the bioanalysis community. Following a period as Senior Applications Specialist for Chromatography, Jon now holds the position of Vertical Marketing Specialist for Pharma &amp;BioPharmawithin Thermo Fisher Scientific, with a view to bringing relevant technologies together to help solve customer challenges.
</blockquote>

Thermo Fisher Scientific: Virtual seminar session 1: Impurity analysis with a focus on nitrosamines

Virtual seminar session 1: Impurity analysis with a focus on nitrosamines

Developing reliable gradient methods is more challenging compared to isocratic methods.
In this seminar we will discuss:
<ul>
<li>Why and when a gradient separation makes sense
</li>
<li>Isocratic vs. gradient
</li>
<li>Sample types
</li>
<li>How to develop a reliable gradient method
</li>
<li>What parameters can maximize gradient resolution
</li>
</ul>
<blockquote>
Presenter: Rita Steed (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Rita Steed began supporting the LC column line for Agilent in 1999. As a Chromatography Specialist (first with Chromatography, Inc., then directly for Agilent), Rita worked on-site with researchers in Pharmaceutical and other industries presenting technical seminars and assisting researchers with troubleshooting and method development. Rita has over 20 years of Chromatography experience in the Biotechnology, Chemical, and Pharmaceutical industries. She has held positions in Research, Sales, and Technical Service. Rita has earned degrees in Microbiology and Life Sciences/Biochemistry. In her current position, she is an inside Application Engineer supporting LC columns.
</blockquote>

Agilent Technologies: Gradient, Reversed Phase HPLC - The Why, What, When and How

Gradient, Reversed Phase HPLC - The Why, What, When and How

Developing reliable gradient methods is more challenging compared to isocratic methods.

Selecting the best GPC solution – column, solvent, calibration standards, detector, etc. – can be difficult.
This presentation will cover the common questions that should be asked and aspects that should be considered when developing a GPC method so that it is robust and reproducible.
Topics that will be covered include:
<ul>
<li>Solvent choice – importance of selection
</li>
<li>Polymer Standards – choosing correctly
</li>
<li>Column choice – organic or aqueous, key selection criteria
</li>
<li>Combining columns of different types – it is NOT always a good idea
</li>
<li>Detectors – appropriate for my sample and calibration standards
</li>
</ul>
Taking time to address each of these specific areas can help you to achieve long term, reproducible, and reliable GPC results. Relevant application examples will be given.
<blockquote>
Presenter: Jean Lane (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Jean has been employed with Agilent since Nov 2010 in technical and applications support and has a primary role supporting Agilent’s full line of LC columns and consumables, which also includes support for Agilent’s GPC/SEC product line. She came to Agilent thru acquisition of Varian and the former Polymer Laboratories. Jean has 20 plus years of technical and applications support for both HPLC and GPC consumable products. In addition to practical chromatography experience in the laboratory, she has had many, many years in her technical role involving customer support providing assistance and troubleshooting for customer chromatography issues.
</blockquote>

Agilent Technologies: GPC: Practical Steps in GPC Method Development

GPC: Practical Steps in GPC Method Development

Common questions that should be asked and aspects that should be considered when developing a GPC method so that it is robust and reproducible.

There are many choices for reversed phase columns.
In this seminar we will look at: The basics of column chemistry including o Silica surface - Chemistry &amp; Physical Properties Bonding Chemistries End-capping Particle size options Totally porous vs. superficially porous columns We will also look at how this fits with our conditions to get good lifetime from our columns.
<blockquote>
Presenter: Rita Steed (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Rita Steed began supporting the LC column line for Agilent in 1999. As a Chromatography Specialist (first with Chromatography, Inc., then directly for Agilent), Rita worked on-site with researchers in Pharmaceutical and other industries presenting technical seminars and assisting researchers with troubleshooting and method development. Rita has over 20 years of Chromatography experience in the Biotechnology, Chemical, and Pharmaceutical industries. She has held positions in Research, Sales, and Technical Service. Rita has earned degrees in Microbiology and Life Sciences/Biochemistry. In her current position, she is an inside Application Engineer supporting LC columns.
</blockquote>

Agilent Technologies: A Look at Column Choices

A Look at Column Choices

 The basics of column chemistry including o Silica surface.

Preventing pressure, peak shape, and retention time problems saves you the time and aggravation of troubleshooting. Join us on a journey through the LC system from the solvent bottles through the detector.
During this free webinar we will make stops to explore:
<ul>
<li>The role your instrument plays
</li>
<li>The benefits of incorporating sample prep into your workflow
</li>
</ul>
The importance of selecting the best column for your analysis Problems can introduce unexpected detours. Plan ahead to insure your sample arrives as expected at its destination.
<blockquote>
Presenter: Rita Steed (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Rita Steed began supporting the LC column line for Agilent in 1999. As a Chromatography Specialist (first with Chromatography, Inc., then directly for Agilent), Rita worked on-site with researchers in Pharmaceutical and other industries presenting technical seminars and assisting researchers with troubleshooting and method development. Rita has over 20 years of Chromatography experience in the Biotechnology, Chemical, and Pharmaceutical industries. She has held positions in Research, Sales, and Technical Service. Rita has earned degrees in Microbiology and Life Sciences/Biochemistry. In her current position, she is an inside Application Engineer supporting LC columns.
</blockquote>
<blockquote>
Presenter: Golnar Javadi (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Golnar Javadi is an applications engineer providing online applications assistance and technical support for LC columns and supplies, Sample Preparation products, and Spectroscopy supplies.
</blockquote>
<blockquote>
Before joining Varian and then Agilent, Golnar worked in the pharmaceutical and nutraceutical industries on method development and quality control. She also taught college level chemistry courses for a few years.
</blockquote>
<blockquote>
Golnar then joined Varian as a technical support specialist, providing customers with method development assistance and technical support on Sample Preparation (SPE, SLE, and Filtration), HPLC, GC, ToxiLab and DAT. After the Varian-Agilent merger, Golnar joined Agilent Technologies as an Applications Engineer. She provides technical support to customers on Sample Preparation products, Liquid Chromatography columns, and Spectroscopy supplies.
</blockquote>

Agilent Technologies: Around the LC System in 45 Slides!

Around the LC System in 45 Slides!

LC system from the solvent bottles through the detector.

Whether your chromatography suddenly changes or you’re not able to reproduce a method from, e.g. a pharmacopeia, isolating the source of the problem can be a challenge.
In this seminar we will develop your troubleshooting skills as we:
<ul>
<li>Discuss common chromatography problems
</li>
<li>Pressure
</li>
<li>Peak Shape
</li>
<li>Retention
</li>
<li>Look at how to isolate the problem
</li>
<li>Chemistry related
</li>
<li>Hardware/software
</li>
</ul>
<blockquote>
Presenter: Rita Steed (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Rita Steed began supporting the LC column line for Agilent in 1999. As a Chromatography Specialist (first with Chromatography, Inc., then directly for Agilent), Rita worked on-site with researchers in Pharmaceutical and other industries presenting technical seminars and assisting researchers with troubleshooting and method development. Rita has over 20 years of Chromatography experience in the Biotechnology, Chemical, and Pharmaceutical industries. She has held positions in Research, Sales, and Technical Service. Rita has earned degrees in Microbiology and Life Sciences/Biochemistry. In her current position, she is an inside Application Engineer supporting LC columns.
</blockquote>

Agilent Technologies: Taking the Trouble Out of Troubleshooting - Is it the Column, Method or Instrument

Taking the Trouble Out of Troubleshooting - Is it the Column, Method or Instrument

Taking the Trouble Out of Troubleshooting

Problems with improper connections are often mistaken for column issues and are a source of many calls to tech support.
In this presentation we’ll discuss:
<ul>
<li>The different types of fittings, including Agilent’s new A-line fittings
</li>
<li>The importance of tubing
</li>
<li>What happens when you don’t make a good connection
</li>
<li>How to make a proper connection
</li>
</ul>
The function of a fitting is simple but a connection made incorrectly can cause problems with your chromatography. Careful attention to making a good one can reduce frustration and save time troubleshooting.
<blockquote>
Presenter: Mark Powell (Application Engineer, Agilent Technologies, Inc.)
</blockquote>
<blockquote>
Mark Powell is an Applications Engineer located at Agilent’s Little Falls site in Wilmington, DE. Before joining Agilent in 2011, Mark worked in the pharmaceutical industry synthesizing, purifying and analyzing drug candidates. He provides applications assistance and technical support for Agilent’s HPLC columns and consumables.
</blockquote>

Agilent Technologies: Making LC Connections - The Good, The Bad, and the Ugly

Making LC Connections - The Good, The Bad, and the Ugly

Problems with improper connections are often mistaken for column issues and are a source of many calls to tech support.