Researchers from CATRIN at Palacký University, together with colleagues from VSB – Technical University of Ostrava and Charles University, have developed a new graphene ink for producing inexpensive and sensitive printed sensors. Using single-atom engineering, they incorporated copper atoms into the material, enabling highly sensitive detection of dopamine – a neurotransmitter responsible for transmitting signals between nerve cells. The approach, <a target="_blank" rel="noopener noreferrer" href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.76796">presented in the journal Advanced Science</a>, has strong potential for use in medical diagnostics.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_8a02ad6a66.webp" alt="CATRIN: Atom by atom. Scientists reveal a new direction in medical diagnostics" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_8a02ad6a66.webp 117w," sizes="100vw" width="1920" height="2560">Single-atom engineering makes it possible to control the chemical reactivity of materials at the level of individual atoms. Its broader application in medical diagnostics has so far been limited by a lack of atomically engineered materials and printable inks based on them. Researchers have now developed a new class of single-atom-doped graphene materials as well as an ink for producing sensitive printed sensors. Copper proved particularly effective for dopamine detection, which is important for biomedical research and the development of advanced diagnostic technologies for diseases including Alzheimer’s disease.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_2_97e419f039.webp" alt="CATRIN: Atom by atom. Scientists reveal a new direction in medical diagnostics" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_2_97e419f039.webp 117w," sizes="100vw" width="1920" height="2560">“The NGA-Cu ink we developed enables the production of fully inkjet-printed, sustainable paper-based electrodes at very low cost. Each sensor requires only 1.3 micrograms of active ink, costs approximately one Czech koruna and provided a stable response for at least three months. The ink is also fully compatible with commonly available materials inkjet printers. This creates significant potential for producing affordable, digitally designed sensors whose function can be tailored atom by atom,” said&nbsp;the corresponding author of the <a target="_blank" rel="noopener noreferrer" href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.76796">paper</a> Michal Otyepka.The basis for this new generation of single-atom inks was nitrogen-doped graphene acid (NGA), which CATRIN researchers developed several years ago. They have now progressively enriched it with different individual metal atoms, including copper, iron and manganese.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_3_c15d831792.webp" alt="CATRIN: Atom by atom. Scientists reveal a new direction in medical diagnostics" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_3_c15d831792.webp 117w," sizes="100vw" width="1920" height="2560">“We found that the electrochemical response depends fundamentally on the type of atom used. While copper atoms significantly enhance the dopamine signal, other metals suppress it. What matters, therefore, is not only the presence of isolated metal atoms but also the specific metal involved. This is a very important finding for the further development of biosensors,” explained first author Martin-Alex Nalepa.The published results introduce a new class of sensing materials with considerable potential for medical diagnostics. The researchers present a broadly applicable platform for developing graphene inks containing individual metal atoms and open the way towards scalable, reproducible and material-efficient production of advanced electrochemical sensors.&nbsp;“We are only at the beginning and are fascinated by the new possibilities opening up before us. We can see that by changing the type of atom, we can control the sensitivity and selectivity of the sensor. In addition to dopamine, we can also determine immunoglobulins very precisely – antibodies whose levels and types may serve as important indicators of autoimmune or infectious diseases,” emphasised Radek Zbořil, a co-author of the paper.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_4_273cd760a5.webp" alt="CATRIN: Atom by atom. Scientists reveal a new direction in medical diagnostics" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_4_273cd760a5.webp 117w," sizes="100vw" width="1920" height="2560">Electrochemical biosensors can find applications not only in medicine but also in food quality control, drinking-water monitoring and environmental pollution monitoring. Their key components are functionalised electrodes, and graphene-based materials have proved particularly suitable for their production. A key factor in the success of the Olomouc researchers was the targeted preparation of graphene ink with the required properties.The research was supported by the TECHSCALE project under the Johannes Amos Comenius Programme.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_5_b1778f77f2.jpg" alt="CATRIN: Atom by atom. Scientists reveal a new direction in medical diagnostics: Project TECHSCALE (No. CZ.02.01.01/00/22_008/0004587) is financed by the MEYS OP JAC Excellent research programme, supported by ERDF/ESF." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CATRIN_Atom_po_atomu_Vedci_ukazali_novy_smer_v_lekarske_diagnostice_5_b1778f77f2.jpg 245w," sizes="100vw" width="620" height="87"><blockquote><h4>Article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.76796">Single-Atom-Enhanced Fully Inkjet-Printed Electrochemical Sensor for Dopamine Detection</a></h4>Martin-Alex Nalepa, David Panáček, Vítězslav Hrubý, Matěj Jendřišák, Rostislav Langer, Michal Langer, Petr Jakubec, Ivan Dědek, Vojtěch Kupka, Michal Mazur, Radek Zbořil, Michal OtyepkaAdv. Sci., 2026, e76796<a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1002/advs.76796">https://doi.org/10.1002/advs.76796</a><h6>licenced under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote><h4>Abstract</h4>Single-atom (SA) engineering offers atomic-level control over interfacial reactivity, yet the lack of printable SA-based inks hinders its practical translation into electrochemical sensing. Here, a fully water-based inkjet-printable ink is introduced based on nitrogen-doped graphene acid (NGA) hosting atomically dispersed Cu centers (NGA-Cu-ink). The ink enables digitally controlled, spatially defined deposition and fabrication of low-cost ($0.04 per sensor), fully inkjet-printed sustainable electrodes on paper. A comparison of NGA functionalized with different SA dopants (Cu, Mn, Fe, Ce) identifies a strong dopant-dependent electrochemical response, with Cu uniquely enhancing the analyte signal while other dopants suppress it, demonstrating that SA identity is a decisive design parameter in printed sensing interfaces profiling sensitivity and selectivity. The functional role of the NGA support is to provide dense anchoring sites (nitrogen and carboxylate groups) that stabilize atomically dispersed metal centers and create adsorption- and electron-transfer–active microenvironments. The NGA-Cu-ink yields enhanced dopamine oxidation, enabling quantitative detection on fully printed devices (limit of detection 9.7 µM; linear range 50–400 µM) and printed-on-electrode platforms (10.6 µM), while maintaining &lt;10% signal variation over 11 weeks. The approach establishes a general route to single-atom graphene-based inks for scalable, reproducible, and low-material-consumption manufacturing of advanced electrochemical sensors.

Atom by atom. Scientists reveal a new direction in medical diagnostics

In the week of September 28, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars">👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</a></h4>👉 Search and filter in the largest global database with over 6 000 GC, LC, MS and spectroscopy webinars.</blockquote><h5>1. Thermo Fisher Scientific: Scalable HPLC workflows for linking antibody productivity, titer, and CQAs</h5><ul><li>Mo, 28.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6478">Registration</a></li></ul>Discover integrated HPLC workflows that provide faster analytical feedback during mAb bioprocess development by linking titer measurements with critical quality attribute (CQA) monitoring.<h5>2. Waters Corporation: Vial Selection, Qualification, and the Evidence Behind the Decision</h5><ul><li>Mo, 28.9.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6529">Registration</a></li></ul>Join Waters for a 30-minute webinar on sample vial selection and qualification. Learn how to mitigate risks in regulated laboratory environments.<h5>3. SelectScience: What LC-UV/MS can reveal about GLP-1 impurities</h5><ul><li>Mo, 28.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6528">Registration</a></li></ul>Discover how combining LC-UV and MS workflows improves confidence in GLP-1 impurity profiling and peptide quality control.<h5>4. Agilent Technologies: Functional ADC Safety Profiling with iPSC-Derived Human Tissues</h5><ul><li>Mo, 28.9.2026 18:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6499">Registration</a></li></ul>Discover how a human iPSC-derived multi-tissue platform enables functional safety profiling of ADCs, helping identify tissue-specific toxicities and improve translational confidence.<h5>5. Tosoh Bioscience: Tosoh Tuesday - Continuous Multi-Column Chromatography for Purification of Inter-alpha Inhibitor Proteins from Human Plasma</h5><ul><li>Tu, 29.9.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6570">Registration</a></li></ul>Discover a scalable purification strategy for Inter-alpha Inhibitor Proteins (IAIP), from anion-exchange capture to continuous multi-column chromatography using Octave BIO.<h5>6. Separation Science: How Does HILIC Work for Oligonucleotides Analysis?</h5><ul><li>Tu, 29.9.2026 16:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6532">Registration</a></li></ul>Learn how HILIC chromatography works for oligonucleotide analysis and explore the retention mechanisms that govern selectivity and method optimization.<h5>7. Metrohm: Meet OMNIS IC – The new benchmark in ion chromatography</h5><ul><li>Tu, 29.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6549">Registration</a></li></ul>Discover the new Metrohm OMNIS IC platform and its modular approach to flexible, reliable ion chromatography workflows.<h5>8. labroots: NanoFCM Analysis of Targeted Particles for Extrahepatic Delivery</h5><ul><li>Tu, 29.9.2026 20:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6533">Registration</a></li></ul>Explore nano-flow cytometry for targeted lipid nanoparticles and learn how single-particle analysis supports the development of extrahepatic drug delivery systems.<h5>9. SelectScience: PFAS in motion: Mapping contaminant pathways across industries and environments</h5><ul><li>We, 30.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6552">Registration</a></li></ul>Explore analytical approaches for mapping PFAS transport from industrial sources through soil, water, and air to understand contaminant pathways across environmental systems.<h5>10. Agilent Technologies: Keeping LC/MS at Peak Performance: Maintenance and Best Practices from Solvent to Signal</h5><ul><li>We, 30.9.2026 18:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6496">Registration</a></li></ul>Learn how preventive maintenance and practical LC/MS best practices, from solvent handling to signal optimization, help maintain performance, reliability, and consistent results.<h5>11. Thermo Fisher Scientific: Master Intact Protein Deconvolution with Chromeleon CDS: Set up and best practices</h5><ul><li>We, 30.9.2026 19:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6562">Registration</a></li></ul>Join this practical webinar focused on setting up and optimizing the Intact Protein Deconvolution workflow in Thermo Scientific Chromeleon software.<h5>12. Phenomenex: Mastering HILIC Chromatography: from Principles to Best Practice</h5><ul><li>Th, 1.10.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6560">Registration</a></li></ul>Learn the principles of HILIC chromatography, including retention mechanisms and practical method development strategies for polar compound analysis.<h5>13. SCIEX: Tackling emerging contaminants in food and water using the ZenoTOF 8600 system</h5><ul><li>Th, 1.10.2026 10:00</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6432">Registration</a></li></ul>Discover how the ZenoTOF 8600 system combines screening and quantitation to address trace emerging contaminants in complex food and water matrices.<h5>14. Agilent Technologies: LC/QTOF MassHunter Acquisition Software Session 1: Acquiring High-Quality Data and Optimizing MS Workflows for Targeted Analysis and Screening</h5><ul><li>Th, 1.10.2026 14:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6579">Registration</a></li></ul>Learn key principles for acquiring high-quality LC/QTOF data using MassHunter Acquisition Software and optimizing MS workflows for targeted analysis and screening.<h5>15. KNAUER: From R&amp;D to GMP – How to Scale LNPs &amp; PNPs Successfully</h5><ul><li>Th, 1.10.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6558">Registration</a></li></ul>Learn how to scale LNP and PNP production from R&amp;D to GMP manufacturing while preserving particle quality and supporting robust process development.

Webinars LabRulezLCMS Week 40/2026

This study develops a chiral LC-MS/MS method with pre-column derivatization for simultaneous determination of carnitine (CAR) and acetylcarnitine (ACA) enantiomers in food. Conversion to 3-nitrophenylhydrazine derivatives followed by separation on a CHIRALPAK ZWIX (−) column provided resolution values above 1.57 for the respective enantiomers.After validation, the method was applied to meat, milk, and fermented soybean products. L-CAR and L-ACA were detected in all tested foods, while trace amounts of D-CAR were identified in the traditional Japanese fermented food Hama-natto, demonstrating the method’s suitability for selective food analysis.<blockquote><h4>The original article</h4><h4><a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S2949771X26000101#sec0010">Development of a chiral liquid chromatography-tandem mass spectrometry for simultaneous determination of carnitine and acetylcarnitine enantiomers in food samples</a></h4>Aogu Furusho, Hiroki Mizuno, Yutaro Nakayama, Eiji Sugiyama, Kenji Kojima, Kenichiro TodorokiJ. Pharm. Biomed. Anal. Open., 2026, 100111, Volume 7<div><a target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S2949771X26000101#sec0010">10.1016/j.jpbao.2026.100111</a></div><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/">CC-BY 4.0</a></h6></blockquote>Selected sections from the article follow. Formats and hyperlinks were adapted from the original.<div><div><div><div><div>Carnitine (CAR) is a functional endogenous compound found in various animals <a style="color:rgb(2, 114, 177);font-size:16px;line-height:26px;text-decoration:none;" target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S2949771X26000101#bib1">[1]</a>. Since CAR has one asymmetric carbon in its structure, the l- and d-enantiomers are present. l-CAR is a cofactor that transports long-chain fatty acids into the mitochondria and promotes energy production via β-oxidation <a style="color:rgb(2, 114, 177);font-size:16px;line-height:26px;text-decoration:none;" target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S2949771X26000101#bib2">[2]</a>. Humans biosynthesize 25% of the required amounts of l-CAR from l-lysine and l-methionine and ingest the remaining 75% from foodstuffs <a style="color:rgb(2, 114, 177);font-size:16px;line-height:26px;text-decoration:none;" target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S2949771X26000101#bib3">[3]</a>, <a style="color:rgb(2, 114, 177);font-size:16px;line-height:26px;text-decoration:none;" target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S2949771X26000101#bib4">[4]</a>. The insufficient intake of l-CAR induces a CAR deficiency <a style="color:rgb(2, 114, 177);font-size:16px;line-height:26px;text-decoration:none;" target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S2949771X26000101#bib5">[5]</a>, and levocarnitine (l-form) is used as the therapeutic drug. Acetylcarnitine (ACA) is an acetylated molecule of CAR and is converted from CAR by carnitine O-acetyltransferase in the human body <a style="color:rgb(2, 114, 177);font-size:16px;line-height:26px;text-decoration:none;" target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S2949771X26000101#bib6">[6]</a>. ACA is also related to energy production and is essential for storing acetyl groups to produce acetylcholine <a style="color:rgb(2, 114, 177);font-size:16px;line-height:26px;text-decoration:none;" target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S2949771X26000101#bib7">[7]</a>. A previous study demonstrated that l-ACA taken from foods was partially hydrolyzed in the body and increased the l-CAR concentration within the tissues of aged rats <a style="color:rgb(2, 114, 177);font-size:16px;line-height:26px;text-decoration:none;" target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S2949771X26000101#bib8">[8]</a>, indicating that CAR and ACA are interconverted. Furthermore, l-ACA has some therapeutic effects to downregulate inflammation-induced angiogenesis <a style="color:rgb(2, 114, 177);font-size:16px;line-height:26px;text-decoration:none;" target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S2949771X26000101#bib9">[9]</a> and to reduce nerve pain <a style="color:rgb(2, 114, 177);font-size:16px;line-height:26px;text-decoration:none;" target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S2949771X26000101#bib7">[7]</a>, <a style="color:rgb(2, 114, 177);font-size:16px;line-height:26px;text-decoration:none;" target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S2949771X26000101#bib10">[10]</a>, making it a promising drug candidate. Both CAR and ACA are also commercially available as supplements to reduce body fat.Meanwhile, the d-isomers don’t have the above functions and are not thought to be present in the human body. Previous studies have revealed some specific functions such that d-CAR inhibited the l-CAR absorption causing CAR deficiency <a style="color:rgb(2, 114, 177);font-size:16px;line-height:26px;text-decoration:none;" target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S2949771X26000101#bib11">[11]</a>, and d-ACA enhanced the efficiency of the drug for the Pompe disease <a style="color:rgb(2, 114, 177);font-size:16px;line-height:26px;text-decoration:none;" target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S2949771X26000101#bib12">[12]</a>. Since the physiological actions of the d-forms and l-forms differ, enantioselective analysis of the CAR and ACA enantiomers is desirable for studying their functions and biokinetics.Several analytical methods have been already developed for the determination of the CAR and ACA enantiomers. In these methods, two approaches were mainly taken; i.e., the reversed-phase separation with the combination of diastereomeric derivatization and the direct separation by an enantioselective column. To convert enantiomers to diastereomers, chiral reagents, such as (+)-1-(9-fluorenyl)ethyl chloroformate <a style="color:rgb(2, 114, 177);font-size:16px;line-height:26px;text-decoration:none;" target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S2949771X26000101#bib13">[13]</a> and l-alanine-β-naphthylamide <a style="color:rgb(2, 114, 177);font-size:16px;line-height:26px;text-decoration:none;" target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S2949771X26000101#bib14">[14]</a>, were used. The conventional ODS column successfully separated the CAR and ACA enantiomers as their diastereomeric derivatives, and the methods were reported to be applicable for the enantiomeric purity check of drug substances. Regarding the chiral liquid chromatographic (LC) method, various types of enantioselective columns have been tested, but it was revealed that the separation of the CAR and ACA enantiomers was quite difficult <a style="color:rgb(2, 114, 177);font-size:16px;line-height:26px;text-decoration:none;" target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S2949771X26000101#bib15">[15]</a>. A CHIRALCEL OD-R column based on the polysaccharide structure was among the few that achieved simultaneous separation of the CAR and ACA enantiomers. The target analytes were derivatized with (α-bromo)methyl phenyl ketone, and the method was applied to the analysis of drug substances <a style="color:rgb(2, 114, 177);font-size:16px;line-height:26px;text-decoration:none;" target="_blank" rel="noopener noreferrer" href="https://www.sciencedirect.com/science/article/pii/S2949771X26000101#bib16">[16]</a>. However, the measurement of foods, pharmaceutical agents, and biological samples has scarcely been performed, likely due to the low selectivity of the LC separation and ultraviolet/fluorescence detection used in these methods. Thus, improving the selectivity of the method is required to expand the range of the measurable samples.In the present study, a chiral LC-tandem mass spectrometric (MS/MS) method has been developed for the simultaneous determination of the CAR and ACA enantiomers. Direct separation using an enantioselective column enables the analysis independent of the optical purity of the reagents, and MS/MS could provide a higher selectivity than those of the previous methods. Furthermore, because CAR and ACA possess an ammonium cation which contributes to the high ionization efficiency, a high sensitivity by MS could also be expected. After the method development and validation, the content analyses of the CAR and ACA enantiomers were performed for meat, milk, and soybean fermented food samples.<h4>2. Experimental</h4><h5>2.4. LC-MS conditions</h5>The LC-MS/MS system consisted of ultra-high performance liquid chromatographic systems (<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/198">ACQUITY H-class</a> and<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/199"> I-class</a>, Waters, Milford, MA, USA) and triple quadrupole mass spectrometers (<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/212">Xevo TQ-S</a> and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/209">TQ-S micro</a>, Waters). The chiral separation of CAR and ACA was performed on a CHIRALPAK ZWIX (-) column (3.0 mm I.D.×250 mm, 3 µm, Daicel Corporation, Osaka, Japan) at room temperature. The mobile phases were 5 mM FA/NH4FA in H2O/MeOH/MeCN (A: 2/9/89 and B: 2/19/79, v/v/v) at the flow rate of 0.25 mL/min. The LC gradient property was as follows: 0–25 min, 100% A; 25.1–45 min, 100% B; 45.1–60 min, 100% A. The MS detection was performed with the following conditions: 3.0 kV spray voltage for ESI positive ionization; 150 L/hr cone gas flow rate; 1000 L/hr desolvation gas flow rate; 150°C source temperature; 500°C desolvation temperature. The selected reaction monitoring (SRM) mode was used for the detection, and the set transitions, cone voltage (CV), and collision energy (CE) for the target compounds are summarized in Table 1. The different CEs were used for 3-NPH-ACA on Xevo TQS (10 eV) and Xevo TQ-S micro (20 eV). Data processing was performed using <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/635">MassLynx v4.2 software</a> (Waters).<h4>3. Results and discussion</h4><h5>3.4. Determination of the CAR and ACA enantiomers in food samples</h5>The developed method was applied to the analysis of the CAR and ACA enantiomers in food samples. CAR and ACA are known to be abundant in animal-based foods [23], thus, beef, pork, chicken, and milk were measured. The measured cuts of meat were the shank for beef, thigh for pork, and thigh for chicken in this study, and these parts are commonly used in commercially-available ground meats. Fermented foods are reported to contain relatively high levels of d-amino acids, and some of them are considered to be produced by bacteria during the fermentation process [24]. To investigate the production of CAR and ACA by bacteria, three fermented foods made from soy beans (miso, soy sauce, and Hama-natto) were analyzed. Hama-natto is a traditional food from the Hamamatsu City area in Shizuoka Prefecture, Japan. Steamed soybeans are fermented with koji mold, then salted and dried in the sun.The chromatograms of the beef and Hama-natto samples are shown in Fig. 4. l-CAR and l-ACA were clearly observed in both samples. The l-forms were also found in the other tested samples, and their quantified values are summarized in Table 4. Comparing the amounts of l-CAR in the meat samples, beef had the highest levels, followed by pork and chicken. The l-ACA levels were also the highest in beef, and chicken contained more than pork.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/J_Pharm_Biomed_Anal_Open_2026_100111_Volume_7_Fig_4_Determination_of_the_CAR_and_ACA_enantiomers_in_beef_56d92bf289.jpg" alt="J. Pharm. Biomed. Anal. Open., 2026, 100111, Volume 7: Fig. 4. Determination of the CAR and ACA enantiomers in beef and Hama-natto samples as their 3-NPH derivatives. The selected ion chromatogram of ACA is shown for 0–30 min, and that of CAR is shown for 30–60 min." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_J_Pharm_Biomed_Anal_Open_2026_100111_Volume_7_Fig_4_Determination_of_the_CAR_and_ACA_enantiomers_in_beef_56d92bf289.jpg 245w," sizes="100vw" width="2247" height="542"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/J_Pharm_Biomed_Anal_Open_2026_100111_Volume_7_Table_4_Amounts_of_l_CAR_and_l_ACA_in_the_food_samples_1c2411fe51.jpg" alt="J. Pharm. Biomed. Anal. Open., 2026, 100111, Volume 7: Table 4. Amounts of l-CAR and l-ACA in the food samples." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_J_Pharm_Biomed_Anal_Open_2026_100111_Volume_7_Table_4_Amounts_of_l_CAR_and_l_ACA_in_the_food_samples_1c2411fe51.jpg 245w," sizes="100vw" width="981" height="447"><h5>3.5. Confirmation of D-CAR in the Hama-natto sample</h5>To confirm the presence of d-CAR in the Hama-natto, four approaches were conducted; i.e., remeasurement of the fraction, detection with a different SRM transition, separation under different LC conditions and use of high-resolution MS. The fraction was placed in a 1.5 mL tube for three min before the MS to purify the d-CAR. The solution (total 750 µL) was dried and dissolved in 50 µL of the mobile phase. The chromatogram obtained by the remeasurement is shown in Fig. 5A, and the result detected by a different SRM transition (297.1 &gt; 102.1) is in Fig. 5B. The peak of d-CAR was clearly observed in both measurements, and the peak shapes were similar. However, the amount of d-CAR was under the LLOQ and could not be quantified. As shown in Fig. 5C, d-CAR was also detected using the different LC conditions described in Section 2.6, suggesting that the peak was definitely derived from the d-CAR. A high-resolution MS analysis detected a molecule with m/z 297.155, which closely matched with the exact mass of 3-NPH-CAR (m/z 297.156). The extracted ion chromatogram of that molecule is shown in Fig. 5D, and the d-CAR peak was clearly observed. These results demonstrated that trace amounts of d-CAR were present in the Hama-natto sample. To the best of our knowledge, this is the first report to find natural d-CAR in foods. One possible origin of this d-CAR is a production by bacteria including koji mold. Some bacteria are known to produce d-amino acids for cell wall formation [32]. The bacteria capable of producing d-CAR may exist and be involved in the fermentation of Hama-natto. Since the l-CAR and l-ACA concentrations in the other fermented foods were lower than that in Hama-natto, there is a possibility to also detect the d-forms from other foods by the improvement of the extraction process. Further research using various food samples is expected.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/J_Pharm_Biomed_Anal_Open_2026_100111_Volume_7_Fig_5_Chromatograms_of_the_3_NPH_d_CAR_fractions_2c9fbf4df7.jpg" alt="J. Pharm. Biomed. Anal. Open., 2026, 100111, Volume 7: Fig. 5. Chromatograms of the 3-NPH-d-CAR fractions analyzed by the different analytical methods. The SRM transitions were 297.1 &gt; 102.1 (A) and 145.1 (B). The fraction was analyzed by LC-MS/MS under the different conditions (C) and LC-TOF-MS (D). The detailed analytical conditions are described in Section 2.6." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_J_Pharm_Biomed_Anal_Open_2026_100111_Volume_7_Fig_5_Chromatograms_of_the_3_NPH_d_CAR_fractions_2c9fbf4df7.jpg 245w," sizes="100vw" width="2663" height="1199"><h4>4. Conclusion</h4>In the present study, a chiral LC-MS/MS method has been developed for the simultaneous determination of the CAR and ACA enantiomers in food samples. The derivatization with 3-NPH extended the retention time and improved the enantiomeric separations especially for CAR. The validated method was successfully applied to the analysis of meat, milk, and soybean fermented food samples, and trace amounts of d-CAR were discovered in Hama-natto. The present method is able to distinguish enantiomers in various samples and can contribute to clarifying the origin of d-CAR in food samples and searching/developing for new functional food products.</div></div></div></div></div>

Development of a chiral liquid chromatography-tandem mass spectrometry for simultaneous determination of carnitine and acetylcarnitine enantiomers in food samples

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Achieving product consistency for beer, wine, cider, and other adult beverages requires the analysis of multiple parameters using several automated and/or wet chemistry procedures.
Many labs still follow the traditional wet chemical methods like colorimetry, titration, and flow analysis, as well as measurement methods such as pH, conductivity, and ion selective electrodes. Integrated discrete analysis consolidates beverage testing and simultaneously automates the analysis of critical parameters resulting in faster turnaround, reduced human error, lower reagent use, and expanded laboratory analytical capabilities. Better testing means better product to retain and expand your customer base. We will present an overview of the integrated discrete analyzer and important parameters to measure in adult beverages.
<blockquote>
Presenter: Hari Narayanan (Product Marketing Manager, Thermo Fisher Scientific)
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<blockquote>
Dr. Hari Narayanan is the Product Marketing Manager at Thermo Fisher Scientific. He has nearly 20 years of experience in managing research activities and applications development. He collaborates with regulatory agencies like ASTM, EPA, EPRI, USP, and AOAC and has been part of several new method developments. He is well-versed in multivariate analysis, sample preparation, titration, ion chromatography, Combustion IC, molecular spectroscopy (FTNIR, FTIR, RAMAN and UV), voltammetry, flash chromatography, particle size analysis, ICP and XRF. He received his B.Sc and M.Sc. in Chemistry from the Madurai Kamaraj University and a Ph.D. in Analytical Chemistry from the University of Madras, India. Before joining Thermo Fisher Scientific, Hari was Director of Strategic Marketing at Metrohm USA.
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Thermo Scientific: Consistent Quality from Consolidated Beverage Testing

Consistent Quality from Consolidated Beverage Testing

Overview of the integrated discrete analyzer and important parameters to measure in adult beverages.

Wet chemical methods are an integral part of modern analytical labs. Many of the regulatory bodies, such as the US EPA, recommend wet chemical methods like colorimetry, titrimetry, and flow analysis, as well as measurement methods like pH, conductivity, and ion selective electrodes for drinking water and wastewater applications.
Why? Because wet chemical methods are proven and modern instrumentation often cannot determine results that many specific wet chemical tests provide. However, these traditional wet chemical methods are tedious, time-consuming, and consume large volumes of samples and reagents.
In this webinar we will provide an overview of US EPA recommended automated wet chemical methods for drinking water and wastewater and discuss several application examples that highlight the benefits of transferring traditional wet chemical methods to the integrated discrete analyzer.
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Presenter: David Glutz (Product Specialist, Thermo Fisher Scientific)
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David Glutz has been working at Thermo Fisher Scientific as a Product Specialist for 12 years. He has strong working and method development knowledge and is the go-to person for the Discrete Analyzer product line. David supports customer training and application development for discrete analyzers, ion chromatography, and sample preparation at the Center of Excellence. Trained in Applied Chemical Technology from the University of Cincinnati’s OMI College of Applied Science, David has a unique background in the environmental field with more than 20 years of experience.
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Thermo Scientific: Automated Environmental Wet Chemical Analysis

Automated Environmental Wet Chemical Analysis

Overview of US EPA recommended automated wet chemical methods for drinking water and wastewater and discuss several application examples.

<ul>
<li>Advances in triple quadrupole ICP-MS for environmental analysis
</li>
<li>Maximizing your lab productivity with true high pressure ion chromatography solutions
</li>
<li>Analysis of VOC and GRO in Water using the TriPlus 500 GC-MS Headspace Autosampler
</li>
<li>At the end of the presentations there will be time for you to ask any questions you have using the chat box
</li>
</ul>
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Presenter: Simon Nelms (Regional Marketing Manager, Trace Elemental, Thermo Fisher Scientific)
</blockquote>
<blockquote>
With the advent of triple quadrupole technology, a new level of interference removal in ICP-MS has been achieved. The implementation of an additional quadrupole before the collision cell of the instrument allows pre-filtering of the ion beam to selectively transmit only the masses of interest, which alleviates the problem of unwanted side interference production in the cell through collisions between other masses in the sample and the cell gas. This pre-filtering capability also allows selective chemical reactions to be conducted in the cell to enhance polyatomic interference removal and, in many cases, solve the problem of isobaric overlap. In this presentation, the latest advances in triple quadrupole ICP-MS technology and how these apply to routine analysis of environmental will be described.
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<blockquote>
Presenter: Seif Mohey (Technical Sales Manager Ion Chromatography, Thermo Fisher Scientific)
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This presentation summarizes how ion chromatography has evolved over the years into today’s multimode technique suitable for solving analytical problems in all areas of interest. The Reagent-Free Ion Chromatography (RFIC) systems with electrolytic eluent generation make it possible to perform a wide range of ion chromatographic separations using only deionized water as eluent ( Just Add water Technology ). Our top of the range, Thermo Scientific™ Dionex™ ICS-6000 HPIC™ system is a modular ion chromatograph, configurable as a single or dual channel system equipped with a modern tablet interface and interactive wellness features offering superior column chemistries to maximize productivity and ease of use. This presentation brings out the advantages of using the ICS-6000 in different applications.
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<blockquote>
Presenter: Daniela Cavagnino (Product Marketing Manager, Thermo Fisher Scientific)
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<blockquote>
Environmental testing laboratories involved in volatile organics determination in water and soil samples will benefit of the innovative design of theThermo Scientific™ TriPlus™ 500 HS autosampler offering scalable productivity, extended recovery and data quality, at the best cost/value. Gasoline Range Organics (GRO) are highly volatile compounds that can be easily extracted from the matrix without the need for time-consuming sample preparation. These chemicals are often present in the environment, especially in ground water and soil, mainly due to contamination incidents during handling, storing or transporting oil and related products. The TriPlus 500 HS autosampler offers a very efficient extraction of the volatiles, maximizing the sensitivity in shorter cycle times. The coupling with the GC-FID configuration provides a rugged solution for quantitative determination of volatile hydrocarbons at ppb levels, representing a robust analytical tool for routine environmental laboratories.
</blockquote>

Thermo Scientific: Innovations in Environmental Analysis

Innovations in Environmental Analysis

Advances in triple quadrupole ICP-MS for environmental analysis.

Conventional wet chemistry is manual, labor intensive, and involves large sample volumes.
We will show how a discrete analyzer enables simultaneous multi-parameter analysis and discuss how fully automated wet chemistry analysis in microliter-scale provides cost efficiency and complements ion chromatography.
<blockquote>
Presenter: Hari Narayanan (Product Marketing Manager, Discrete Industrial Analyzer, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Dr. Hari Narayanan has nearly 20 years of experience in managing research activities and applications development. He collaborates with regulatory agencies and has been part of several new method developments. He is well-versed in multivariate analysis, sample preparation, titration, ion chromatography, molecular spectroscopy (FTNIR, FTIR, RAMAN and UV), and voltammetry. He received his B.Sc. and M.Sc. in Chemistry from the Madurai Kamaraj University and a Ph.D. in Analytical Chemistry from the University of Madras, India.
</blockquote>

Thermo Scientific: Automate Your Wet Chemistry Analysis

Automate Your Wet Chemistry Analysis

How a discrete analyzer enables simultaneous multi-parameter analysis.

Water is a vital resource for refineries and petrochemical plants. Supporting processes that pre-treat crude oil, remove and recover sulfur, and prevent corrosion, catalyst poisoning, and fouling are vital to keep operations running efficiently and safely.
Maintaining optimal water chemistry requires many measurements for multiple analytes. We will discuss a variety of topics including: which technology provides the best measurement and throughput for your needs; what other automated techniques can be applied in place of traditional wet chemistry methods, such as titration, to reduce error and hazards; and how the combination of discrete analyzer and ion chromatography (Disc-IC) solves routine and comprehensive water analysis problems.
<blockquote>
Presenter: Hari Narayanan (Product Marketing Manager, Thermo Fisher Scientific)
</blockquote>
<blockquote>
Dr. Hari Narayanan has nearly 20 years of experience in managing research activities and applications development. He collaborates with regulatory agencies and has been part of several new method developments. He is well-versed in multivariate analysis, sample preparation, titration, ion chromatography, combustion IC, molecular spectroscopy (FTNIR, FTIR, RAMAN, and UV), and voltammetry. He received his B.Sc. and M.Sc. in Chemistry from the Madurai Kamaraj University and a Ph.D. in Analytical Chemistry from the University of Madras, India.
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<blockquote>
Presenter: Kirk Chassaniol (Manager, Application Scientists, Thermo Fisher Scientific)
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Kirk is currently a technical leader in the Ion Chromatography (IC) field support group within the North American Centers of Excellence. Over the last 28 years, he has been involved in IC application and customer support in sales and marketing roles. He has helped with the development of IC methods and standards for chloride and sulfate in ethanol, cations in hydrogen cell feed gas, and combustion IC within the ASTM D02 and D03 Elemental Analysis subcommittee.
</blockquote>

Thermo Scientific: It Takes a Lot of Water to Turn Oil into Gold

It Takes a Lot of Water to Turn Oil into Gold

Variety of topics including: which technology provides the best measurement and throughput for your needs.

Automated executions of chemical synthesis and discovery has risen as a critical enabling technology. New tools combining advanced robotics with experiment planning by machine learning, known as self-driving labs, are now attainable. However, the optimal deployment of these technologies remains under development, requiring a recursive design-make-build cycle dedicated to tuning and evolving the robotic platform.This new approach has been termed ‘flexible automation’ and enables the cost and time-effective design, construction and reconfiguration of automated experiments. By leveraging many of the principles from Industry 4.0, including rapid fabrication, Internet-of-Things devices, cloud-based software, and open-source API we have created a set of simple reconfigurable tools to address a diverse set of applications spanning pharmaceutical process chemistry and even impacting mining and resource extraction. These rapid improvements are made possible through the fusion of best-in-class existing hardware (eg, &nbsp;Unchained Labs Junior for liquid handling and HTE, Mettler-Toledo EasyMax for large scale automated lab reactor, Agilent UPLC for online analysis, Vaportec R-Series for continuous plug-flow reactions) with a variety of bespoke tools and code to integrate complicated workflows. This presentation will introduce this method and provide case studies.Key Learning Objectives:<ul><li>Learn strategies to rapidly develop hybrid and fully automated experimental workflows</li><li>Learn best practices to design and deploy autonomous reaction optimization for chemical synthesis</li><li>See case studies for integrating automation into small molecule synthesis programs</li></ul>Who Should Attend:<ul><li>Process development and medicinal chemists</li><li>Automation scientists and engineers</li><li>Scientists involved in high throughput experimentation &nbsp;</li></ul><blockquote>Presenter:&nbsp;Jason Hein (CEO and Co-Founder, Telescope Innovations)Presenter:&nbsp;Melissa O'Meara (Forensic Science Consultant, C&amp;EN Media Group)</blockquote>

C&EN: Flexible Automation: A new approach to meet evolving chemistry challenges

Flexible Automation: A new approach to meet evolving chemistry challenges

Learn strategies to rapidly develop hybrid and fully automated experimental workflows

New approach to meet evolving chemistry challenges

<h5>The Problem&nbsp;</h5>Current manual buffer exchange techniques sacrifice nucleic acid, protein, AAV, and LNP sample recovery for convenience and don’t scale well to your sample volumes and capacity.<h5>The Solutions&nbsp;</h5>Automating buffer exchange solves scale-up issues while saving tons of time and serving up high sample recovery. We've developed two flavors of automated buffer exchange to handle a wide range of capacity and throughput needs. Unagi is the first completely hands-free, benchtop buffer exchange solution that’s perfect for the everyday handful of samples that need to be quickly buffer exchanged or concentrated up - Unagi can handle up to 8 samples of 0.5 – 8 mL at a time. Big Tuna is a high-throughput automated buffer exchange platform that can exchange and concentrate up to 96 different samples and buffers on volumes from 100 μL - 8 mL.<h5>The Proof&nbsp;</h5>Join this live side-by-side demo of Unagi and Big Tuna to see each platform in action and learn about the benefits of benchtop vs high-throughput automated buffer exchange. See for yourself how automating buffer exchange takes the workload off your hands while delivering accuracy and recovery rates you just can’t get with manual methods. &nbsp;<blockquote>Presenter:&nbsp;Del Ray Jackson (Market Manager, Buffer Exchange &amp; Automation, Unchained Labs)Moderator: Ross Walton, PhD (Sr. Applications Scientist, Unchained Labs)</blockquote>

Unchained Labs: See how Unagi & Big Tuna satisfy any size craving for fast, hands-free buffer exchange

See how Unagi & Big Tuna satisfy any size craving for fast, hands-free buffer exchange

Live demo of Unagi and Big Tuna to see each platform in action and learn about the benefits of benchtop vs high-throughput automated buffer exchange. 

Hands-free buffer exchange with Unagi and Big Tuna

<h5>The Problem&nbsp;</h5>Part of the development of a biologic drug is finding a formulation that optimizes its stability. Two key protein stability parameters are melting and aggregation temperature, Tm and Tagg. To effectively screen many different formulations with the goals of ranking and refining them, you need a tool that keeps tabs on many stability parameters of many samples all at once.&nbsp;<h5>The Solutions&nbsp;</h5>Uncle is the original all-in-one stability platform that characterizes stability of biologics in high throughput with only 9 µL of sample. It allows you to follow melting and aggregation of the protein simultaneously and to use the data to rank and rate formulation excipients for their influence on the behavior of your analyte.&nbsp;<h5>The Proof&nbsp;</h5>In this webinar, we’ll present a case study on Eurofins’ formulation development of a fusion protein. We screened different excipients for their influence on stability to find an optimized formulation that balances thermal stability and minimizes the tendency of the analyte to aggregate. &nbsp;<blockquote>Presenter:&nbsp;Andree Mueller (Senior Product Manager for Aunty and Honeybun, Unchained Labs)Presenter: Dorien Van Lysebetten (Senior Scientist, Eurofins CDMO)Presenter: Lien Saerens (Pharmaceutical Development Manager, Eurofins CDMO)Host: Georgina Hughes (Editorial Team, SelectScience)</blockquote>

Unchained Labs: Master the balancing act of biologic formulation development with Uncle

Master the balancing act of biologic formulation development with Uncle

In this webinar, we’ll present a case study on Eurofins’ formulation development of a fusion protein. 

Biologic formulation development with Uncle

Fat determinations in food and feed matrices is a routine analysis for several testing and food processor labs, as it is part of labelling process and QC testing. Nowadays, the process still relies on outdated and matrix-dependent methods which use obsolete and time-consuming technologies. This workshop, live from Milestone Lab, presents a new approach to fat determinations that simplify the lab workflow and increase the productivity. Learn how your laboratory could gain value and see the benefits of whom has already implemented.<h4>Key topics:</h4><ul><li>Fat determination process: conventional vs microwave approach</li><li>One single method for any food matrix</li><li>Complete fat determinations: Total Fat, Crude Fat, FAME</li><li>Real life Case Study: Eurofins Scientific</li></ul><blockquote>Speaker: Roberto Boschini (Product Manager at Milestone)</blockquote>

Milestone: Gain productivity in fat determinations on any matrix

Gain productivity in fat determinations on any matrix

This workshop, live from Milestone Lab, presents a new approach to fat determinations that simplify the lab workflow and increase the productivity.

With throughput capabilities of 24 samples in only 40 minutes, the ETHOS X with fastEX-24 rotor reduces overall analysis costs by increasing productivity. The combination of lower solvent volumes, less maintenance need and the use of inexpensive disposable glass vials enhances your environmental lab's competitiveness and profitability. In this webinar, you will learn five (5) tips to reduce your analysis costs in organic pollutants determination on any environmental matrix, like soil, sediments and many other.<ul><li>Improved productivity</li><li>Minimal solvent volume</li><li>No cleaning step</li><li>Easy to implement</li><li>Full recovery of the analytes</li></ul><h5>Make your environmental laboratory more competitive!</h5><blockquote>Speaker: Roberto Boschini (Product Manager at Milestone)</blockquote>

Milestone: 5 tips to reduce your analysis costs in organic pollutant determination

5 tips to reduce your analysis costs in organic pollutant determination

In this webinar, you will learn five tips to reduce your analysis costs in organic pollutants determination on any environmental matrix.