Oligonucleotide and mRNA Analysis Resource Roundup

What do chromatography, gemstones, rainbows and even cats have in common? At KNAUER’s latest Girls’ Day in Berlin, 15 schoolgirls explored exactly that question. Through a series of hands-on activities, they discovered how HPLC instruments are developed and manufactured, learned the basics of spectroscopy and chromatography, and met women working across science, engineering, product management and company leadership.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_1_A_student_observes_the_rainbow_spectrum_of_white_light_8ef24d9700.jpeg" alt="KNAUER: Figure 1 A student observes the rainbow spectrum of white light." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_1_A_student_observes_the_rainbow_spectrum_of_white_light_8ef24d9700.jpeg 228w," sizes="100vw" width="624" height="427"><h4>A Day to Explore STEM Careers</h4>Girls’ Future Day, widely known as Girls’ Day, gives schoolgirls across Germany an opportunity to experience professions in which women are still underrepresented. Instead of learning about careers only in the classroom, participants can spend a day inside companies, laboratories and technical workplaces and see what these jobs actually involve.KNAUER has participated in Girls’ Day for 17 years, and demand for places has become consistently high. The attraction is easy to understand: visitors do not simply listen to presentations. They can experiment, assemble components, talk directly with employees and discover how science and engineering are applied in everyday work.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_2_Hands_on_experience_and_wonder_at_Girls_Day_2025_98da525b3a.jpg" alt="KNAUER: Figure 2 - Hands-on experience and wonder at Girls’ Day 2025: 13 interested girls assembled pump heads, learned what HPLC is, and how such equipment is developed" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_2_Hands_on_experience_and_wonder_at_Girls_Day_2025_98da525b3a.jpg 125w," sizes="100vw" width="1024" height="1280"><blockquote>“That moment when the girls realize, with sparkling eyes, just how cool science can be—that’s exactly why I love Girls’ Day. It’s worth every bit of the effort!” – Dr. Kristin Folmert, chemist and product manager at KNAUER</blockquote><h4>From Laboratory Instruments to a Wide Range of Careers</h4>At KNAUER wissenschaftliche Geräte GmbH, laboratory instrumentation is designed, developed, manufactured, tested and marketed from Berlin for customers around the world.That requires far more than chemists alone. The company brings together people working in mechanical production, logistics, media design, mechatronics, software development, science, product management and company management.For the participating girls, this offered a chance to meet women following very different career paths and to see that a technology company can provide opportunities across many disciplines.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_3_The_girls_learned_what_chromatography_and_HPLC_are_a7db4e8eb3.jpg" alt="KNAUER: Figure 3 - The girls learned what chromatography and HPLC are, what they are used for, and how a UV/Vis detector works. They then built their own handheld spectroscope and experimented with white light and various color filters." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_3_The_girls_learned_what_chromatography_and_HPLC_are_a7db4e8eb3.jpg 245w," sizes="100vw" width="1024" height="609"><h4>Women in Science and Technology at KNAUER</h4>Women account for 37% of KNAUER’s workforce, with particularly strong representation in scientific and management positions. The company reports a gender pay gap of 1.84% for 2026, compared with an unadjusted German gender pay gap of 16% in 2025. Women also hold 44% of leadership positions at KNAUER, including several positions performed on a part-time basis.The company emphasizes practical measures intended to make technical careers accessible to a wider range of employees. These include flexible work models, support for childcare and technical solutions such as indoor cranes for handling heavy components.During Girls’ Day, these policies become less abstract. Participants meet scientists, engineers and managers who can describe how they entered their professions and how their careers developed.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_4_During_a_visit_to_the_equipment_development_department_scientist_Thy_Vu_talks_about_her_career_at_KNAUER_3bd9af2786.jpg" alt="KNAUER: Figure 4 - During a visit to the equipment development department, scientist Thy Vu talks about her career at KNAUER. She wrote her bachelor’s thesis here and then worked as a student assistant in development during her master’s program. Subsequent to completing her master’s degree, she accepted a permanent position at KNAUER in the development department. Today, she is developing the pump drive of the future and tells the fascinated girls which gemstones are used in such a pump (sapphires and rubies)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_4_During_a_visit_to_the_equipment_development_department_scientist_Thy_Vu_talks_about_her_career_at_KNAUER_3bd9af2786.jpg 245w," sizes="100vw" width="1024" height="614"><h4>Role Models and First-Hand Career Insights</h4>Several KNAUER employees are also involved in <a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/groups/13080121/">International Women in Chromatography</a>, a network supporting women and non-binary professionals working in chromatography.Throughout the day, the students encountered women at different stages of their careers: from university students and young scientists to experienced product managers, developers and Managing Director Alexandra Knauer.The message was not simply that STEM careers are available to women, but that scientific and technical work can take many forms. Networking, curiosity, willingness to ask questions and confidence in one’s own abilities were recurring themes throughout the event.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_5_A_girl_works_intently_and_with_great_care_on_her_spectroscope_ed94a2a049.jpg" alt="KNAUER: Figure 5 - A girl works intently and with great care on her spectroscope. None of the girls glance at their phones; they are all polite, and many feel comfortable asking questions openly. We are very excited about this generation of bright young talents." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_5_A_girl_works_intently_and_with_great_care_on_her_spectroscope_ed94a2a049.jpg 127w," sizes="100vw" width="405" height="496"><h4>Learning HPLC by Doing</h4>The scientific part of the day began with the basic principles of high-performance liquid chromatography (HPLC).To make separation easier to understand, the group first experimented with light and heavy balls inside a large glass column. From there, the discussion moved to the individual components of an HPLC system.One analogy compared an HPLC instrument with the human body: the pump moves liquid much like the heart circulates blood, separation takes place in the column, and the detector observes the separated compounds through their interaction with light.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_6_The_HPLC_and_its_various_modules_depicted_as_human_organs_855ab67aac.jpg" alt="KNAUER: Figure 6 - The HPLC and its various modules, depicted as human organs." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_6_The_HPLC_and_its_various_modules_depicted_as_human_organs_855ab67aac.jpg 245w," sizes="100vw" width="1210" height="670"><h4>Building a Spectroscope and Seeing Light Differently</h4>Each participant then constructed a small handheld spectroscope.The task required both careful reading and manual dexterity, particularly when fitting the delicate lens. Working together, the girls quickly developed better ways to complete the assembly—a small example of how real development projects evolve through cooperation and continuous improvement.Once finished, the spectroscopes revealed the spectrum of white light as a rainbow together with visible spectral features. Colored filters placed between the light source and the spectroscope then demonstrated how absorption changes the observed spectrum.This connected the practical activity with concepts introduced earlier in the day: visible light, wavelength, absorption and how optical signals eventually become peaks in HPLC detection.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_7_A_11_year_old_girl_gazes_fascinated_at_her_rainbow_4f713de2ae.jpg" alt="KNAUER: Figure 7 - A 11-year-old girl gazes fascinated at her rainbow and notices that while all the colors are visible, some areas are brighter while others are quite dark. “Is the spotlight not pure white, or is my spectroscope absorbing light?” Such clever questions arise when girls are encouraged to explore things for themselves." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_7_A_11_year_old_girl_gazes_fascinated_at_her_rainbow_4f713de2ae.jpg 200w," sizes="100vw" width="1024" height="800"><h4>Inside Instrument Development and Manufacturing</h4>The program then moved from theory into KNAUER’s production environment.In the mechanical manufacturing area, participants saw CNC machines and robotic systems producing precision components for laboratory instruments. They could watch parts of an HPLC pump head taking shape directly from metal components and learn why accurate machining is essential for reliable instrument performance.<blockquote>“This is like science fiction!” – Mariko Stahr, Girls’ Day participant</blockquote>In the development department, engineer Thy Vu demonstrated her work on pump-drive technology and explained how developers investigate parameters such as motor torque. The girls were also able to handle some of the materials used inside an HPLC pump.One detail generated particular interest: components made from sapphire and ruby. This opened a discussion about material properties, crystal structures and why instrument developers benefit from understanding chemistry as well as engineering.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_8_Thomas_Mueller_explains_to_the_girls_how_CNC_machines_mill_the_housing_for_a_pump_head_bd714b9b50.jpg" alt="KNAUER: Figure 8 - Thomas Müller explains to the girls how CNC machines mill the housing for a pump head from a block of metal and why precision is crucial in this process. On the left is one of the robotic arms that continues working even at night, allowing employees to focus solely on daytime work and more demanding tasks. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_8_Thomas_Mueller_explains_to_the_girls_how_CNC_machines_mill_the_housing_for_a_pump_head_bd714b9b50.jpg 245w," sizes="100vw" width="1278" height="468"><h4>Assembling a Real HPLC Pump Head</h4>The final practical station brought the participants into instrument assembly.Each girl was given the opportunity to assemble a pump head herself. The work proved more demanding than it initially appeared, requiring both hands to coordinate several components accurately.With guidance from KNAUER training supervisor Ronald Berger, the participants completed their assemblies before each pump head underwent a final technical check to verify that the pistons moved correctly.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_9_A_girl_is_screwing_the_check_valve_with_the_check_valve_holder_i_cf84fb4375.jpg" alt="KNAUER: Figure 9 - A girl is screwing the check valve with the check valve holder into the pump head. Everything is then tightened using a torque wrench." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_9_A_girl_is_screwing_the_check_valve_with_the_check_valve_holder_i_cf84fb4375.jpg 179w," sizes="100vw" width="376" height="327">The day concluded with lunch and another opportunity to speak with Managing Director Alexandra Knauer, who has long supported initiatives intended to improve the visibility of women and encourage young people to consider STEM careers.Participants received certificates and “I love HPLC” bags with small gifts before leaving KNAUER with their own impressions of what a future in science and technology could look like.<h4>So Where Do the Cats and Rainbows Come In?</h4>The rainbow seen through a spectroscope provides a simple demonstration of the same basic optical principle used in many analytical measurements.When white light is dispersed, its different wavelengths become visible as a spectrum. If part of that light is absorbed by an object or substance, the resulting spectrum changes. Measuring which wavelengths are absorbed can therefore reveal information about the material interacting with the light.The article illustrates the idea with a deliberately simple example: a cat sitting in front of a light source may absorb most of the light, but its silhouette still provides information about what is blocking the beam.Similarly, analytical detectors can obtain information about molecules by measuring how they interact with light.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_10_The_cat_actually_absorbs_all_the_light_af8452f58d.jpg" alt="KNAUER: Figure 10 - The cat actually absorbs all the light, but its outline still lets us know that there’s a fluffy cat sitting there. In HPLC, a[SD5.1] molecule’s light absorption also tells us a great deal about its identity. " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_10_The_cat_actually_absorbs_all_the_light_af8452f58d.jpg 236w," sizes="100vw" width="1024" height="676">The same principle also helps explain the colors of evening sunlight. When sunlight travels through a longer path in the atmosphere, shorter-wavelength blue light is scattered more strongly, leaving proportionally more of the longer-wavelength red and orange light reaching the observer.For the students at KNAUER, concepts such as these transformed HPLC and spectroscopy from abstract scientific terminology into something they could build, observe and discuss themselves.And that is ultimately the purpose of Girls’ Day: to show young people that science and technology are not distant subjects confined to textbooks, but fields full of practical questions, creative problem solving and possible future careers.

Girls Just Wanna Have Fun With KNAUER – A Girls' Day Full of Rainbows

Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 21st September 2026? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!<blockquote>👉 <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library">SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</a></blockquote><blockquote>👉 Need info about different analytical techniques? Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library">LabRulezGCMS</a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library">LabRulezICPMS</a> libraries.</blockquote>This week we bring you application notes by KNAUER and Shimadzu, technical note by Thermo Fisher Scientific and poster by Waters Corporation / SOFT!<h3>1. KNAUER: Precise Catechin Profiling in Various Types of Tea</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/VFD_0198_knauer_precise_catechin_profiling_in_various_types_of_tea_d607cde5ba.pdf">Full PDF for download</a></li></ul>Fresh tea leaves contain high concentrations of catechins, which have many beneficial properties. These include antioxidant, anti-inflammatory as well as antimicrobial effects, and it is even claimed that they have the potential to prevent cancer [1]. In addition, the taste and mouthfeel of a tea strongly depend on its catechin profile. The catechin content of tea leaves varies based on cultivation area, age and variety, as well as on how they are fermented, processed and packed. Therefore, the catechin content is an important marker for the quality of tea.&nbsp;The analysis of catechins can be challenging. The structural similarity of the catechin isomers and other closely related compounds result in similar behavior and a difficult separation (Fig. 1). Catechins possess many phenolic hydroxyl groups, which are prone to secondary interactions, like hydrogen bonding. Classical as well as highly endcapped C18 columns offer only limited retention and selectivity for catechins. Therefore, the KNAUER column portfolio has been expanded to include a pentafluorophenyl (PFP)-modified stationary phase (Eurospher II 100-3 PFP column 50 x 2 mm). It offers optimal separation of the catechins based on hydrophilic, hydrophobic and π-π-interactions. The column withstands acidic eluents (pH 1.5–10) as well as 100 % aqueous conditions, which are beneficial for the retention of hydrophilic compounds. The KNAUER Gradient Prediction Tool assisted with the challenging method development which is described in detail in the TechNote “The Gradient Prediction Tool: Method Development for the Separation of Catechins from Tea”. Here, the application of the optimized method for the identification and quantification of catechins in tea extracts is shown. The seven compounds specified in ISO-14502-2 (2005), as well as two additional catechins known as (+)-gallocatechin and (–)-gallocatechin gallate, were quantified.<h4>MATERIAL AND METHODS</h4><ul><li>Pump: <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2374">P8.1L</a>; high pressure gradient&nbsp;</li><li>Liquid Handler: <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1454">LH 8.1L </a>With FastWash station, and Robotic cooler. Loop: 20 µl.</li><li>Thermostat: <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2376">CT 2.1L&nbsp;</a></li><li>Detector: <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2424">DAD 6.1L&nbsp;</a></li><li>Flow cell: Analytical LightGuide flow cell (50 mm, 6 µl)&nbsp;</li><li>Software: ClarityChrom 10.1</li></ul><h4>CONCLUSION&nbsp;</h4>The application note demonstrates the reliable separation and quantification of catechins and caffeine in tea extracts using the new KNAUER PFP column. Using an optimised gradient predicted with the KNAUER Gradient Prediction Tool, nine tea-related compounds were separated in under 23 minutes. The tested tea samples showed different catechin content highlighting how strongly tea composition depends on the product type and processing.<h3>2. Shimadzu: New Derivatization Method for Quantitative Analysis of Δ⁹-THC-COOH in Urine</h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_01_01215_en_c98174629b.pdf">Full PDF for download</a></li></ul><h5>User Benefits</h5><ul><li>The risk of limited availability of stable isotope-labeled standards can be avoided by synthesizing internal standards through derivatization.&nbsp;</li><li>The derivatizing agent IPPAH and its corresponding stable isotope IPPAH-d6 can be synthesized easily and inexpensively from acetone (or acetone-d6).&nbsp;</li><li>This approach achieves sufficient sensitivity and quantitative accuracy for the determination of Δ⁹-THC-COOH in urine.</li></ul>In Japan, the Cannabis Control Act and the Narcotics and Psychotropics Control Act were amended in December 2024. While cannabis was legalized for industrial and medical uses, stricter cannabis regulations have been enacted to prevent harm from its abuse. The primary psychoactive cannabinoid, delta-9-tetrahydrocannabinol (Δ⁹-THC), is extensively metabolized in the body and is excreted mainly in urine and feces as 11-nor-9-carboxy-THC (Δ⁹-THC-COOH) and its glucuronide conjugates. Consequently, Δ⁹-THC-COOH must be analyzed to confirm cannabis use. For LC-MS/MS quantitation, the stable isotope-labeled internal standard Δ⁹-THC-COOH-d3 is commonly used to correct for matrix effects. However, most suppliers of stable isotope standards are located in the U.S., making these standards difficult to obtain due to import procedures. Furthermore, there may be additional importrelated supply risks for stable isotope standards in the future.&nbsp;This Application News describes a technique for quantitating Δ⁹-THC-COOH using an internal standard that is synthesized easily and inexpensively by derivatization with IPPAH (1- isopropylpiperidine carboxylic acid hydrazide), which characteristically reacts with carboxyl groups, and its corresponding stable isotope IPPAH-d6.<h4>Analysis Conditions&nbsp;</h4>LC-MS/MS analysis conditions are shown in Table 1. The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=1&amp;search=Nexera+XR">Nexera XR</a> and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=1&amp;search=LCMS-8050">LCMS-8050 systems</a> were used.<h4>Conclusion&nbsp;</h4>Derivatization with IPPAH and its stable isotope analog, IPPAHd6, enabled the simple and inexpensive preparation of an internal standard. This approach provides sufficient sensitivity and accuracy for the determination of Δ⁹-THC-COOH in urine. Most stable isotope-labeled standards are supplied by foreign manufacturers, creating a risk of delays or difficulties in procurement due to import/export regulations. By synthesizing the internal standard through derivatization, this risk can be minimized.<h3>3. Thermo Fisher Scientific: High-throughput quantitative proteomics with Evosep Eno and the Orbitrap Astral Zoom Mass Spectrometer</h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/tn_004544_ov_astralzoom_evosepeno_htp_proteomics_tn004544_na_en_f31db9084e.pdf">Full PDF for download</a></li></ul>High-throughput proteomics is a critical enabling technology for large clinical studies, high-content drug screening, and systems biology research, allowing for comprehensive and quantitative analysis of complex proteomes across large sample cohorts within practical timeframes. As biological and translational studies expand in scale and complexity, the ability to generate deep and reproducible proteome measurements across thousands of samples has become increasingly essential for robust biomarker discovery, network-level systems modeling, and downstream analyses. In these contexts, accurate and precise protein quantitation must be maintained without sacrificing throughput, placing stringent demands on the performance and robustness of both LC instruments and mass spectrometers.&nbsp;To meet these increasing analytical demands, the Evosep Eno was developed as a high‑throughput LC system that combines robustness, ease of use, and highly reproducible chromatography. It offers six standardized methods: 30, 60, 100, 200, 300, and 500 samples per day (SPD), allowing users to select the throughput that aligns best with their study goals.1 These predefined methods ensure consistent gradient delivery, highly stable retention times, and reproducible system performance across instruments and laboratories.2 By reducing LC‑related variability and simplifying everyday operation, the Evosep Eno offers a strong and consistent foundation for large‑scale proteomics workflows, particularly those relying on short gradients and high reproducibility required for downstream quantitative analysis.<h4>Experiment</h4><h5>Instrumentation&nbsp;</h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=291&amp;search=evosep+eno">Evosep Eno&nbsp;</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1959">Orbitrap Astral Zoom Mass Spectrometer&nbsp;</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2464">Thermo Scientific™ EASY-Spray™ Ion Source&nbsp;</a></li><li>Evosep™ Pod for EASY-Spray Ion Source</li></ul><h5>Software&nbsp;</h5><ul><li>Biognosys Spectronaut® 19.7 software&nbsp;</li><li>MacCoss Lab Software Skyline-Daily V25.1</li></ul><h4>Summary&nbsp;</h4><h5>Seamless and easy integration for high-throughput proteomics&nbsp;</h5>Evosep Eno integrates seamlessly with the Orbitrap Astral Zoom Mass Spectrometer, supported by EASY-Spray source-compatible columns, emitters, and the Evosep Pod column oven for a simple, streamlined, high-throughput workflow.&nbsp;<h5>Deep proteome coverage at 500 SPD&nbsp;</h5>Optimized MS parameters for the standard 500 SPD Evosep Eno gradient enabled identification of more than 6,500 protein groups and 71,000 modified peptides from three replicates of 200 ng Pierce HeLa Digest/PRTC Standard.<h5>Reproducible quantitation across standard gradients&nbsp;</h5>Across all standard Evosep Eno gradients, the workflow delivered highly reproducible label-free quantification, with median protein group %CVs at or below 5.2%, while identifying more than 10,500 protein groups and 190,000 modified peptides from five replicates of 200 ng Pierce HeLa Digest/PRTC Standard at 30 SPD.&nbsp;<h5>Robust chromatography at ultra-high throughput&nbsp;</h5>Chromatographic performance remained stable and robust at 500 SPD, with nearly 100 consecutive runs showing PRTC retention time standard deviations below 0.4 seconds and a median of 6 DPPP.&nbsp;<h5>Strong linearity for confident quantitation&nbsp;</h5>Quantitative performance remained strong at 500 SPD, with PRTC peptides showing excellent linearity across the active gradient (R² &gt;0.98) when spiked from attomolar to femtomolar concentrations.<h3>4. Waters Corporation / SOFT: COMPARATIVE EVALUATION OF HIGH RESOLUTION MASS SPECTROMETRY ACQUISITION STRATEGIES FOR THE DETECTION AND ANALYSIS OF ILLICIT DRUG SUBSTANCES</h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/720009592_0bd2b5ee6a.pdf">Full PDF for download</a></li></ul><div><div><section><div><div><div><div><div><div>The poster compares two high-resolution time-of-flight mass spectrometry acquisition strategies for toxicology screening: targeted Tof-MRM and data-independent Tof-MSE, both implemented on a Waters <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1148">Xevo MRT MS</a> coupled to an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/199">ACQUITY UPLC I-Class FTN PLUS System</a>. The aim was to determine whether these approaches could meet routine service requirements for drug testing while also broadening the number of substances that can be detected beyond conventional targeted panels. Urine samples were prepared across a wide concentration range for 20 target analytes, and the methods were also applied to 20 anonymized authentic urine samples.Both workflows used a 15-minute LC separation on an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1952">ACQUITY HSS C18 column</a> under positive electrospray ionization. In the targeted Tof-MRM mode, selected precursor ions were isolated and fragmented, with quantifier and qualifier ions monitored for sensitive quantitative analysis. In contrast, Tof-MSE operated in a data-independent mode, alternating between low and elevated collision energies to collect accurate-mass precursor and fragment-ion information for a broad range of compounds. Data were processed in the waters_connect platform using MS Quan for Tof-MRM and UNIFI with the Waters Toxicology Library, containing more than 2,100 drugs and metabolites, for Tof-MSE.The targeted Tof-MRM method provided the highest sensitivity, with limits of detection ranging from 0.05 to 0.5 ng/mL in fortified urine. The broader Tof-MSE workflow achieved LODs of approximately 0.5 to 5 ng/mL. When both strategies were applied to authentic urine samples, they showed excellent qualitative agreement. Importantly, Tof-MSE detected additional compounds outside the predefined target panel, including commonly encountered medications, benzodiazepines, antidepressants, and illicit drug substances that would not have been captured by the targeted method alone.Overall, the study shows that Tof-MRM can deliver sensitivity comparable to conventional tandem-quadrupole LC-MS/MS for targeted urinary drug analysis, while Tof-MSE adds broader sample characterization and retrospective screening capability. Used together, the two acquisition strategies provide a flexible approach that combines sensitive quantification of predefined analytes with expanded screening for unexpected or previously untargeted drug substances in complex biological samples.</div></div></div></div></div></div></section></div></div>

News from LabRulezLCMS Library - Week 39, 2026

Article

Application

Popularization

Science and research

Poster

A unique company dedicated to serving science helping our customers drive productivity and accelerate results. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services.

Thermo Fisher Scientific

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

KNAUER

Unchained Labs

Phenomenex

SelectScience

SCIEX

Evosep Biosystems

Waters Corporation

The development of peptide drugs necessitates efficient bioanalytical assays for accurate measurement in biologicals. Liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) is preferred technology for its specificity and sensitivity. However, LC-MS/MS assays for peptides such as the high-profile diabetes and weight loss GLP-1 receptor agonist Semaglutide, pose significant method development challenges.In this webinar, we present new data demonstrating a comprehensive and streamlined approach to optimized LC-MS/MS quantification of peptides, addressing the common challenges of efficient sample preparation, MRM selection, non-specific binding, sensitivity and robustness, through the example of the development of an assay for the quantitation of Semaglutide in plasma.<h5>Key Learning Objectives:</h5><ul style="list-style-type:disc;margin-top:0cm;" type="disc" id="isPasted"><li style="line-height:115%;margin-bottom:10.0pt;mso-list:l0 level1 lfo1;tab-stops:list 36.0pt;">Learn step-by-step how to streamline bioanalysis workflows for large peptides such as Semaglutide.</li><li style="line-height:115%;margin-bottom:10.0pt;mso-list:l0 level1 lfo1;tab-stops:list 36.0pt;">Discover practical solutions to common obstacles like non-specific binding and efficient mrm optimisation.</li><li style="line-height:115%;margin-bottom:10.0pt;mso-list:l0 level1 lfo1;tab-stops:list 36.0pt;">Gain insights into boosting sensitivity without compromising the reliability of your bioanalytical methods</li></ul><div><blockquote>Presenter: Samantha Ferries (Senior Applications Chemist, Waters Ltd)Samantha Ferries received her PhD in proteomics from the University of Liverpool in 2018. Since joining Waters in 2018, Samantha has worked on a variety of application areas including Biomedical Research, Pharmaceuticals and Food &amp; Environmental, with a focus on LCMS/MS method development. In 2021 Samantha was part of the team that worked to develop the SARS-CoV-2 LCMS Kit (RUO) to detect &amp; quantify SARS-CoV-2 signature NCAP peptides.</blockquote></div>

Mastering the Quantitative Bioanalysis of Large Peptides and Proteins: A Case Study of GLP-1 Receptor Agonist Semaglutide in Plasma

We present new data demonstrating a comprehensive and streamlined approach to optimized LC-MS/MS quantification of peptides, addressing the common challenges.

A Case Study of GLP-1 Receptor Agonist Semaglutide in Plasma

Looking to improve your lab’s efficiency and streamline your nLC-MS processes?Whether you’re new to Evosep or simply curious about how we can simplify your workflows, this session offers valuable insights for labs at all levels.Our technology combine user-friendly workflows with automated processes. It empowers researchers, even without extensive expertise, to confidently use liquid chromatography mass spectrometry-based proteomics in their work.What to expect<ul><li>Streamline your workflows with increased throughput</li><li>Achieve reliable and reproducible results with minimal effort</li><li>Maximize productivity in your lab with practical tips and strategies</li></ul>Our technology combine user-friendly workflows with automated processes. It empowers researchers, even without extensive expertise, to confidently use liquid chromatography mass spectrometry-based proteomics in their work.This webinar is your opportunity to gain a comprehensive understanding of the Evosep One’s key features and how it can seamlessly integrate into your current processes. You’ll also have the chance to ask questions during our live Q&amp;A session, hosted by Nicolai Bache, VP, Proteomics Research at Evosep.&nbsp;<blockquote>Presenters: Gabriel Bracamontes (product specialist at evosep)Presenters:&nbsp;Martin Nørmark Thesbjerg (Laboratory engineer, Department of Health science and technology, university of aalborg)</blockquote>

Evosep Biosystems: A beginner’s guide to Evosep 2025

A beginner’s guide to Evosep 2025

This webinar offers a comprehensive overview of the Evosep One’s key features and its seamless integration into your current processes

The presentation highlights the advancements and importance of cloud-based data management in the biopharmaceutical industry. Dr. Kristensen discusses how the shift from traditional data handling methods to cloud solutions has revolutionized their workflow, enabling access to vast amounts of data from anywhere, which is crucial given the exponential increase in data generation. He outlines the adoption of native mass spectrometry (MS) techniques since 2018, inspired by advancements seen at NIBA, leading to significant growth in data production.&nbsp;The presentation emphasizes the robustness and reliability of their MS platforms, particularly SEC MS, which has proven effective across multiple instrument generations. Dr. Kristensen underscores the importance of centralized data and metadata retrievability for efficient and accurate analysis. The talk concludes with appreciation for collaborative efforts and the critical role of innovative technologies in driving impactful scientific advancements in oncology and other therapeutic areas.Learning points<ul><li>Cloud-Based Data Management: The transition to cloud-based solutions is essential for handling the exponential increase in data generation.</li><li>Advancements in Mass Spectrometry: The adoption of new mass spectrometry (MS) techniques, such as native MS and SEC MS, has significantly improved the robustness and reliability of analytical platforms.</li><li>Impact of Modifications on Therapeutic Efficacy and Safety: The importance of understanding how various modifications, such as glycation and deamidation, impact the safety and efficacy of biopharmaceutical products.</li></ul>Who should attend?<ul><li>Researchers and Scientists: Those working in glycomics, proteomics, and related fields who are interested in the latest advancements and methodologies.</li><li>Biotechnology and Pharmaceutical Professionals: Professionals involved in the development and commercialization of therapeutics who are looking for ways to accelerate their processes and enhance innovation.</li><li>Academic and Training Institutions: Institutions focused on bioprocessing research and training that can leverage new technologies and approaches to enhance their programs and facilities.</li></ul><blockquote>Presenter:&nbsp; Dr. Dan Bach Kristensen (Principal Scientist, Symphogen)Dan Bach Kristensen holds a Ph.D. in Biology and a Bachelor of Science in Chemistry. Dan is specialized in protein chemistry and mass spectrometry (MS), for which he initially applied in the field of proteome research in Japan and then later in Denmark. For the past 15 years, Dan has been working with analytical development in the biopharmaceutical industry on projects ranging from early discovery through to product registration. Clinical indications include bleeding disorders, neutropenia, autoimmune diseases, and oncology. Dan currently works as a principal scientist at Symphogen, which is specialized in the development of antibodies and antibody mixtures for the treatment of cancer.</blockquote>

Thermo Fisher Scientific: The merger of automated LC fractionation & in-depth characterization

The merger of automated LC fractionation & in-depth characterization

How the shift from traditional data handling methods to cloud solutions has revolutionized their workflow, enabling access to vast amounts of data from anywhere

Automated LC fractionation & in-depth characterization

The presentation showcases the innovative partial T1 digest strategy developed at the University of Sheffield for sequencing mRNA therapeutics. This approach, which utilizes LCMS, enables rapid and efficient sequence validation with over 90% coverage in less than 90 minutes.&nbsp;The technique involves generating overlapping fragments that are visualized through advanced mapping tools, providing clear, color-coded linear maps and spiral plots that indicate sequence coverage and confidence levels. This method has proven particularly valuable for large mRNA molecules, such as self-amplifying RNAs, which can be up to 678,000 nucleotides in length. The collaboration with manufacturing groups exemplifies the practical application of this technology in real-world scenarios, ensuring the integrity and efficacy of mRNA therapeutics. The presentation concludes by highlighting the establishment of a dedicated RNA facility at the University of Sheffield, which aims to further streamline and enhance mRNA analysis and characterization.Learning points<ul><li>Critical Quality Attributes of mRNA: Understanding and monitoring the critical quality attributes (CQAs) of mRNA therapeutics and vaccines are essential.</li><li>Advanced Sequencing Techniques: The use of advanced sequencing methods, such as Sanger sequencing and next-generation sequencing, is crucial for ensuring the correct identity of mRNA sequences.</li><li>Impurity Monitoring and Safety: Monitoring impurities, such as double-stranded RNA and residual DNA from the manufacturing process, is vital for the safety of mRNA therapeutics.</li></ul>Who should attend?<ul><li>Researchers and Scientists: Those working in molecular biology, biochemistry, and pharmaceutical sciences who are interested in the latest techniques for mRNA analysis and characterization.</li><li>Biopharmaceutical Professionals: Professionals involved in the development and production of mRNA-based therapeutics and vaccines, particularly those focusing on quality control and regulatory compliance.</li><li>Analytical Development Teams: Teams dedicated to improving analytical methods for validating the sequence and integrity of mRNA therapeutics.</li></ul><blockquote>Presenter:&nbsp; Prof. Mark Dickman (Professor, University of Sheffield)Prof. Dickman obtained a first-class honours degree in biochemistry/chemistry and his Ph.D. at the Krebs Institute, University of Sheffield. He then joined a biotechnology company, Transgenomic Ltd, and since 2003 has worked in the Dept. of Chemical and Biological Engineering at the University of Sheffield, where his research focuses on the development of analytical methods to characterize biomolecules including mRNA and oligonucleotide therapeutics.</blockquote>

Thermo Fisher Scientific: Characterization and sequence mapping of large RNA and mRNA therapeutics using HRAM

Characterization and sequence mapping of large RNA and mRNA therapeutics using HRAM

The presentation showcases the innovative partial T1 digest strategy developed at the University of Sheffield for sequencing mRNA therapeutics

HRAM for RNA & mRNA therapeutics: characterization, mapping

Ulli Honester, a team leader from Solvias, presented on advancements in mass spectrometry for identifying extractables and leachables (E&amp;L). With over 20 years of experience in proteomics, metabolomics, and small molecule identification, Ulli emphasized that the new state-of-the-art ENL technology is user-friendly and not complex.&nbsp;The presentation highlighted the process of sample preparation and analysis, underscoring the importance of automated peak picking software and high-resolution spectrometers. This technology is crucial for analyzing the thousands of compounds in the human metabolome, aiding in precise identification of markers. The automated systems allow researchers to focus on more critical tasks, enhancing efficiency and patient safety by accurately identifying extractables in drug product formulations. The talk&nbsp;concluded with a discussion on the challenges of peak separation and the reality of dealing with a vast database of compounds, emphasizing the need for advanced software solutions.&nbsp;Learning points&nbsp;<ul><li style="color:#212529;mso-list:l0 level1 lfo1;tab-stops:list 36.0pt;" id="isPasted">Advancements in Mass Spectrometry for E&amp;L Analysis: Attendees will gain insights into the latest state-of-the-art technologies in mass spectrometry that simplify the identification and analysis of extractables and leachables, making the process more user-friendly and efficient.</li><li id="isPasted">Automated Data Processing: The presentation emphasizes the importance of using automated software for peak picking and deconvolution, allowing researchers to focus on critical tasks by reducing the effort required for routine data processing.</li><li>Application of Metabolomics Techniques: By applying techniques learned from metabolomic studies, attendees will understand how to identify significant markers and differences between groups, such as treated versus non-treated samples, enhancing the precision of their analytical studies and contributing to patient safety.</li></ul>Who should attend?&nbsp;<ul><li style="color:#212529;mso-list:l0 level1 lfo1;tab-stops:list 36.0pt;" id="isPasted">Analytical chemists and laboratory scientists specializing in mass spectrometry.</li><li id="isPasted">Pharmaceutical researchers and developers focused on drug formulation and safety.</li><li>Quality control and assurance professionals in the pharmaceutical and biotechnology industries.</li></ul>

Thermo Fisher Scientific: State-of-the-art E&L is not rocket science

State-of-the-art E&L is not rocket science

Ulli Honester, a team leader from Solvias, presented on advancements in mass spectrometry for identifying extractables and leachables (E&L).

Implementation of the recently adopted guideline ICH Q2(R2) on Analytical Procedure Validation can present challenges. In this webinar, Dr. Margareth Marques from the USP will discuss practical guidance around accuracy, precision, limit of quantitation and limit of detection. Then Neil Lander from Waters Corporation will walk us through an Empower CDS tool that enhances the efficiency, accuracy, and compliance of the method validation process. A panel discussion will follow.&nbsp;Key Learning Objectives<ul><li id="isPasted">Address challenges in the implementation of Q2(R2)</li><li>Discover the benefits of the Empower Method Validation Manager</li></ul>Who should attendPharmaceutical testing laboratory scientists and managers, pharmaceutical quality control staff, scientific review staff of regulatory bodies for pharmaceutical products involved with LC procedures and anyone involved in method validation.<blockquote>Presenter: Margareth R. C. Marques, Ph.D. (Sr. Principal Scientist, United States Pharmacopeia)Margareth Marques, Ph.D., is a Sr. principal scientist at the Science Department at the United States Pharmacopeia, Scientific liaison to the USP Expert Committee on Dosage Forms working on general chapters for performance tests (dissolution/drug release), and for some pharmaceutical dosage forms (products applied to the skin, ophthalmic products, etc.), also responsible for the USP general chapters on osmolality, method validation and method transfer. Dr. Marques is also responsible for developing specifications for reagents, test solutions, buffer solutions, etc., used in USP – NF monographs. She manages the USP database on chromatographic columns, the USP database on dissolution methods and the USP web site on column equivalency. She has a B.Sc. and an M. Sc. both in Pharmacy by the University of Sao Paulo, Brazil. She has a Ph. D. in Analytical Chemistry by the State University of Campinas, Brazil. She managed analytical laboratories at Ciba-Geigy, Sandoz, and Astra.Presenter: Neil Lander (Principal Product Manager - Informatics Group, Waters Corporation)Neil has worked for Waters Corporation since 1994 and has held a variety of positions including Technical Support Specialist, Technical Trainer, Manager Customer Education and currently, Principal Marketing Manager in Waters in the Informatics group. Neil provides internal support for Empower CDS software and is focused on developing laboratory software solutions that help organizations achieve their scientific and operational objectives. Prior to joining Waters Corporation, he was an analytical chemist where he gained experience in both the cosmetics and specialty chemical industries.Presenter: Moderated by: Isabelle Vu Trieu (Pharmaceutical Market Development Manager, Americas, Waters Corporation)Isabelle is a business development professional dedicated to delivering benefits to analytical scientists in the life sciences industry. With over 20 years of experience in providing chromatography and mass spectrometry solutions, Isabelle is particularly interested in helping pharmaceutical scientists achieve the data quality and integrity needed to drive decisions for drug quality, safety and efficacy. Isabelle joined Waters in 2009 and currently manages the development of the pharmaceutical market in the Americas. She holds Masters’ degrees in Chemistry from Columbia University and the University Claude Bernard in Lyon, France as well as a Chemical Engineering degree from Ecole Supérieure de Chimie Physique Electronique in Lyon, France.</blockquote>

Waters Corporation: Solving Problems That Matter - a Waters webinar series featuring USP speakers

Method Validation

We´ll discuss practical guidance around accuracy, precision, limit of quantitation and limit of detection and next we´ll walk you through an Empower CDS tool.

Episode 12: Method Validation

<div id="zephr-body-wall"><div>Development and production of IVT mRNA vaccines require measurements of Critical Quality Attributes (CQAs), such as identity, purity, quality, and quantity. Orthogonal methods developed for such purposes are outlined in the USP guidelines for mRNA vaccines.Agilent Technologies provides many analytical solutions that are used by leading pharmaceutical companies in early-stage drug development through production quality control (QC) and final product release. These systems help users save time and money with optimized workflows, streamlined processes, and fast time-to-results.Whitney Pike, M.Sc, Application Scientist and Dr. Sonja Schneider, Manager, Application Development, Agilent Technologies, will discuss how automated electrophoresis and LC/MS systems solutions from Agilent provide reliable insights for IVT mRNA workflows at many steps, from QC of the initial plasmid DNA, throughout the IVT process, to the finished mRNA drug product.Key learning objectives<ul><li>Explore QC throughout the entire IVT mRNA workflow, including data from various nucleic acids and LNP analyses</li><li>Discover how Agilent instruments/technologies, such as the Fragment Analyzer and LC/MS systems, can be used for different CQAs</li><li>Learn how Agilent is working together with its partners to provide reliable insights for all aspects of the IVT mRNA workflow</li></ul>Who should attend?<ul><li>Researchers, lab managers, lab directors, QA/QC managers performing IVT mRNA analysis in biotherapeutics research and production</li></ul>Certificate of attendance All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.For Research Use Only. Not for use in diagnostic procedures. PR7001-2498<blockquote>Presenter: Whitney Pike, MA (Application Scientist, Agilent Technologies)Whitney joined Agilent in 2016 and is an Application Scientist with a focus on the Agilent Automated Electrophoresis instruments. She played a pivotal role in the release of the Femto Pulse system as a scientist on the product development team. She completed her master’s degree in biology, with an emphasis on cellular, molecular, and developmental biology, before working at a core facility, responsible for performing next-generation sequencing studies.Presenter:&nbsp;Dr. Sonja Schneider (Dr. Sonja Schneider, Manager, Application Development, Agilent Technologies)Dr. Sonja Schneider completed her diploma degree in biology and her PhD in biochemistry before joining Agilent in 2011 as an Application Scientist for biopharma applications. She progressed into her current role as Manager, of the Application Development Team in 2016, whilst simultaneously working in the laboratory on up-to-date biopharma applications.Presenter:&nbsp;Olivia Long (Olivia Long, Editorial Team, SelectScience) (moderator)</blockquote></div></div>

Select Science: From Start to Finish: How Agilent Can Support Better Decisions in IVT mRNA-Based Biopharmaceutical Analysis

From Start to Finish: How Agilent Can Support Better Decisions in IVT mRNA-Based Biopharmaceutical Analysis

We will discuss how automated electrophoresis and LC/MS systems solutions from Agilent provide reliable insights for IVT mRNA workflows at many steps.

Agilent's Support in IVT mRNA Biopharmaceutical Analysis

Overview<ul><li>General troubleshooting approach</li><li>HPLC troubleshooting steps and diagnosing tips</li><li>Preventive maintenance and column care</li></ul>Key Learning Points<ul><li>Understand systematic elimination as the best approach for troubleshooting</li><li>Learn the steps to identify and solve chromatographic problems</li><li>Discover column CQA as a tool to help identifying if it’s a system or column related issues</li><li>Know the benefit of filtration and using a guard</li></ul>Who Should AttendAny scientists who would like to gain more knowledge on HPLC troubleshooting or anyone who is experiencing challenges with identifying, solving and avoiding HPLC issues.<blockquote>Presenter: Grace Guo (Senior Technical Specialist, Phenomenex)Grace Guo graduated from the Johns Hopkins University with a Master’s degree in Material Science and Engineering. She joined Phenomenex Technical Team in 2017 providing technical support globally. With more than 9 years of experience on SPE, HPLC and GC, she delivered 80+ seminars and webinars globally covering food and environmental, clinical, pharma and biopharma industry.</blockquote>

Phenomenex: LC Troubleshooting Quick Guide: Spot Problems Fast & Fix Them Like a Pro!

LC Troubleshooting Quick Guide: Spot Problems Fast & Fix Them Like a Pro!

In this webinar - General troubleshooting approach, HPLC troubleshooting steps and diagnosing tips and preventive maintenance and column care.

LC Troubleshooting Quick Guide: Spot Problems Fast & Fix 

We invite you to join our webinar on nitrosamine and NDSRIs, specifically examining their analysis and implications in the pharmaceutical industry. Nitrosamines, a group of potentially carcinogenic impurities, have gained considerable attention in recent years because of their presence in certain drug substances. It is essential to understand their analytical characteristics to ensure patient safety and adhere to regulatory guidelines. Let’s delve into the world of pharmaceutical analysis together!Discussion points:<ul><li>Understanding nitrosamines and NDSRIs: an overview</li><li>Analytical techniques for detection and quantification</li><li>Regulatory landscape and compliance</li><li>Real case studies of drug substances</li><li>Column selection for nitrosamines analysis</li></ul>

SCIEX: Unlocking precision: nitrosamine and NDSRI analysis 

Unlocking precision: nitrosamine and NDSRI analysis 

We invite you to join our webinar on nitrosamine and NDSRIs, specifically examining their analysis and implications in the pharmaceutical industry.

Testing stability of your proteins and formulations can feel like being buried alive when screening boat loads of candidates and conditions. Most classic tools are either inflexible, one-hit wonders that don’t give the full stability picture or seriously low-throughput, creating major bottlenecks that eat up valuable time you need for everything else you’ve got to get done, like yesterday.Aunty is the fastest and highest throughput protein stability characterization tool on the planet. Load up to 96 of your samples into its plate and Aunty will power through piles of thermal melting and aggregation experiments at unmatched speeds - reading fluorescence, SLS and DLS of the whole plate every minute of a thermal ramp. Screen gobs of candidates and conditions with as many replicates as you want. Aunty busts out plates of results with unprecedented speed and data resolution.Join this webinar to see how to set up and run an Aunty experiment. Get a walk-through of Aunty’s data analysis of &nbsp;Tm &amp; Tagg and colloidal stability experiments and get a peek at the highest resolution stability data you’ve ever seen.<blockquote>Presenter: Andre Mueller, PhD (Marketing Manager, Biologic Solutions, Unchained Labs)Andre Mueller, PhD, is the Product Manager for Aunty and Honeybun at Unchained Labs, where he supports the development of biologic and gene therapy drugs. He specializes in fluorescence, static and dynamic light scattering, focusing on biophysical characterization of proteins and viral vectors. His research background spans from structural biology to plant physiology, with experience in labs across Germany, Sweden, Denmark, and the USA. Andre earned his PhD at the Carlsberg Laboratory and completed a postdoctoral fellowship at Stanford University.Moderator: Ross Walton, PhD (Sr. Applications Scientist, Unchained Labs)</blockquote>

Unchained Labs: Meet Aunty, the Queen of high-throughput protein stability characterization