<p>Dear colleagues and guests,</p>
<p>On behalf of the organizing committee and organizing institutions, it is a great pleasure to welcome you to <a href="http://ms-prague2021.uochb.cas.cz/index.php"><strong>the Prague meeting on historical perspectives of mass spectrometry</strong></a>. The conference is held on the inauguration of <a href="https://www.ms-museum.org/"><strong>the Czech Mass Spectrometry Museum</strong></a> and celebrates the <strong>70th anniversary of mass spectrometry</strong> in our country.</p>
<p><a href="http://ms-prague2021.uochb.cas.cz/registration.php"><strong>REGISTRATION</strong></a></p>
<p><a href="http://ms-prague2021.uochb.cas.cz/index.php"><strong>Prague Meeting on Historical Perspectives of Mass Spectrometry</strong></a></p>
<h3><strong>Confirmed Speakers</strong></h3>
<ul>
<li><a href="http://www.biosciences-labs.bham.ac.uk/cooper/"><strong>Prof. Helen J. COOPER</strong></a> (University of Birmingham, Birmingham, UK)</li>
<li><a href="https://www.hecklab.com/"><strong>Prof. Albert J. R. HECK</strong></a> (Utrecht University, Utrecht, The Netherlands)</li>
<li><a href="https://holcapek.upce.cz/"><strong>Prof. Michal HOLČAPEK</strong></a> (University of Pardubice, Pardubice, Czech Republic)</li>
<li><a href="https://orcid.org/0000-0003-3158-0637"><strong>Prof. Karel LEMR</strong></a> (Palacky University Olomouc, Olomouc, Czech Republic)</li>
<li><a href="https://faculty.skoltech.ru/people/evgenynikolaev"><strong>Prof. Evgeny NIKOLAEV</strong></a> (Skolkovo Institute of Science and Technology, Moscow, Russia)</li>
<li><a href="https://www.jh-inst.cas.cz/jh_employee/polasek"><strong>Dr. Miroslav POLÁŠEK</strong></a> (Heyrovský Institute of Physical Chemistry of the CAS, Prague, Czech Republic)</li>
<li><a href="https://bart.chemi.muni.cz/index.php/en/"><strong>Prof. Jan PREISLER</strong></a> (Masaryk University, Brno, Czech Republic)</li>
<li><a href="https://www.chem.tu-berlin.de/helmut.schwarz/"><strong>Prof. Helmut SCHWARZ</strong></a> (Technische Universität Berlin, Berlin, Germany)</li>
<li><a href="https://www.ice.mpg.de/ext/?id=438"><strong>Dr. Aleš SVATOŠ</strong></a> (Max Planck Institute for Chemical Ecology, Jena, Germany)</li>
<li><a href="http://www.jh-inst.cas.cz/~spanel/"><strong>Prof. Patrik ŠPANĚL</strong></a> (Heyrovský Institute of Physical Chemistry of the CAS, Prague, Czech Republic)</li>
<li><a href="https://sites.google.com/a/uw.edu/turecek-group/"><strong>Prof. František TUREČEK</strong></a> (University of Washington, Seattle, WA, USA)</li>
</ul>
<p>The origins of mass spectrometry in the Czech Republic date back to the <strong>1950s</strong> when <strong>the first mass spectrometer was built</strong>. Despite the post-war shortage and considerable international isolation of socialist Czechoslovakia, the device was successfully completed and used in the newly founded <strong>Czechoslovak Academy of Sciences</strong>. Later, commercial instruments started to appear. Mass spectrometry became increasingly important and the community started to grow. Since 1985, summer courses <strong>&quot;School of Mass Spectrometry&quot;</strong> have been organized regularly. The number of participants in this popular annual one-week event is now <strong>over two hundred</strong>. <strong>National scientific conferences on mass spectrometry</strong> have been organized biennially since 2011. Mass spectrometry has become a very important and widely used technique for research and industry.</p>
<p><a href="https://www.ms-museum.org/"><strong>The Czech Mass Spectrometry Museum</strong></a> has been established at <strong>the Institute of Organic Chemistry and Biochemistry of the CAS</strong> in Prague. The museum aims to collect and display <strong>artifacts related to mass spectrometry</strong>, especially those associated with the local geographical region. The technical museum mostly shows the key <strong>components of mass spectrometers</strong> used in the past and in contemporary laboratory practice. It also collects and displays <strong>historical documents</strong>, <strong>photographs</strong>, <strong>books</strong>, etc. The museum&#39;s mission is expressed in two words: <strong>education</strong> and <strong>inspiration</strong>. It demonstrates technologies hidden behind the cover and inside the vacuum systems, thus allowing a better understanding of how the mass spectrometers actually work. Displayed technical solutions, prototypes, ideas, and stories can be inspiring for students, scientists, as well as instrument designers.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/8619b6eab01a4ec18b531bf1a7d20dff/obrazek.png" alt="IOCB Prague: The Czech Mass Spectrometry Museum"/></p>
<p>The Prague Meeting on Historical Perspectives of Mass Spectrometry is a <strong>two-day conference</strong> devoted to history, status and future perspectives of mass spectrometry. The event will bring an exciting program combining <strong>presentations</strong> from honorable <strong>Czech</strong> and <strong>international scientists</strong>, <strong>representatives of producing companies</strong> mapping the historical development of their instruments, and <strong>young colleagues</strong> early in their careers. The early evening poster session will be conveniently followed by a social evening with dinner. The organizing committee will make any possible effort to make sure that your participation will be a scientifically rewarding and pleasurable experience.</p>
<h5><strong>Josef Cvačka</strong></h5>
<p><em>Chair of the PMHPMS</em></p>
<p><a href="https://ms.group.uochb.cz/en"><strong>Mass Spectrometry Research-Service Group</strong></a></p>
<p><a href="https://www.uochb.cz/en"><strong>Institute of Organic Chemistry and Biochemistry of the CAS</strong></a></p>


Prague Meeting on Historical Perspectives of Mass Spectrometry - Early registration!

<p><strong>MS/MS (Tandem) spectra can be used to identify unknowns employing library searches. This is accomplished in much the same approach as that employed for EI GC-MS with the NIST search software. The much improved NIST Search Version 2.4 is included with the 2020 library release.</strong> </p>
<p>I will attempt to introduce the user to the use of the <strong>NIST Version 2.4 search software</strong> employing NIST, Wiley, “crowd-sourced (MoNA)”, and user libraries for the <strong>identification of unknowns</strong>.</p>
<p>NIST has an ambitious program to extend their already comprehensive, high-quality MS/MS databases. </p>
<p>See the following link: <a href="https://littlemsandsailing.files.wordpress.com/2020/12/xiaoyu_yang_asms2020_presentation.pdf">NIST Pipeline for Extending MS/MS Libraries</a></p>
<p>This involves a very comprehensive process for <strong>selecting</strong> pertinent compounds for purchase and subsequent <strong>analyses</strong>. The problem with variability of the spectra is reduced by analyzing the samples on a <strong>variety of instruments</strong> at a <strong>variety of energy levels</strong> (20 steps). In addition, many different <strong>precursor ions</strong> and <strong>fragment ions</strong> are characterized (MSⁿ). This has already led to a very large high quality library of <strong>accurate mass MS/MS spectra in the 2020 release version</strong> (31K compounds/1.3 M spectra) and the effort is ongoing.</p>
<h3><strong>The Part VIII will cover:</strong></h3>
<p>Detailed Handouts including tables of content are available in the <a href="https://lcms.labrulez.com/library?search=lc%2Fms%20unknown%20identifications%20using%20msms%20libraries&amp;manufacturerItems=55">LabRulezLCMS library</a>.</p>
<ul>
<li>Introduction of Presenter, James Little</li>
<li>Table of Contents</li>
<li>Series Topics</li>
<li>Introduction to Approach</li>
<li>Origin of Term “Known Unknowns”</li>
<li>Overall Process Including NIST Library Searches of EI and Tandem Spectra</li>
<li>ChemSpider Internet Searches</li>
<li>CAS Registry Using SciFinder and STN Express</li>
<li>Summary Comparing ChemSpider and CAS Registry Approaches</li>
<li>Example 1:  SciFinder Search of CAS Registry for UV Additive in Polymer</li>
<li>Example 2:  SciFinder Search of CAS Registry for More Obscure Compound</li>
<li>Example 3:  ChemSpider Identification of Additive in Polymer by Monoisotopic Mass</li>
<li>Live Demo YouTube Presentation</li>
<li>Presentation References (Internet Links)</li>
<li>Acknowledgements</li>
</ul>
<h3><strong>The past sections have focused on:</strong></h3>
<ul>
<li><p><a href="https://lcms.labrulez.com/article/1068"><strong>Part I: Overview of Software and User-Customized Configurations</strong></a></p>
</li>
<li><p><a href="https://lcms.labrulez.com/article/1088"><strong>Part II: NIST Search Software and Libraries</strong></a></p>
</li>
<li><p><a href="https://lcms.labrulez.com/article/1110"><strong>Part III: More Detailed Discussion of MSMS Hybrid Search</strong></a></p>
</li>
<li><p><a href="https://lcms.labrulez.com/article/1130"><strong>Part IV: Importing MSMS Spectra</strong></a></p>
</li>
<li><p><a href="https://lcms.labrulez.com/article/1162"><strong>Part V: NIST Structure Searches</strong></a></p>
</li>
<li><p><a href="https://lcms.labrulez.com/article/1221"><strong>Part VI: MS Interpreter Correlation of Substructure to MSMS Ions</strong></a></p>
</li>
<li><p><a href="https://lcms.labrulez.com/article/1367"><strong>Part VII: Using and Creating Other MSMS Libraries</strong></a></p>
</li>
</ul>


LC/MS Unknown Identifications Using MSMS Libraries Part VIII: Identification of Unknowns with “Spectraless” Libraries

<p><strong>In 2021, the LabRulez portals are further expanded in all directions. The number of documents in the field of separation techniques and mass spectrometry attacks 14,000 and there are already over 1,000 webinars in the database.</strong></p>
<p>In the coming months, we also plan <strong>to launch other modules</strong> available or in preparation on our CZ portals <a href="https://gcms.cz/"><strong>LabRulezGCMS CZ</strong></a> and <a href="https://lcms.cz/"><strong>LabRulezLCMS CZ</strong></a>. Take a look at what you can expect soon.</p>
<p>Thanks to <strong>state-of-the-art technology</strong>, <strong>world-unique filtering</strong> in the library of applications or webinars and a comprehensive <strong>connection of related information</strong>, LabRulez portals are a place where you can find <strong>the right information quickly</strong>, <strong>easily</strong> and <strong>clearly</strong>, as is not possible anywhere else.</p>
<p>These are the main reasons why you <strong>liked us</strong> and you <strong>regularly return</strong> to us not only in the Czech Republic, but increasingly also in the full English version of our global portals.</p>
<p><strong>And we are preparing even more for you.</strong></p>
<p>Whether you are <strong>a commercial company</strong>, <strong>a research group</strong> or <strong>an institution</strong> or <strong>a laboratory</strong> - <strong>LabRulez portals</strong> are a place where you can <strong>be seen</strong> and bring new and interesting information to the field of <strong>not only analytical chemistry</strong>.</p>
<h5><strong>1. Create a profile in the <a href="https://gcms.cz/companies">Companies section</a></strong> (CZ version available only)</h5>
<h5><strong>2. Add your applications, posters, presentations, technical or scientific articles, manuals and more to the <a href="https://gcms.labrulez.com/library">Library section</a></strong></h5>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_Document_library_with_advanced_search_algorithm_and_filtering_options_a1175ca744/LabRulez-Document-library-with-advanced-search-algorithm-and-filtering-options.png" alt="LabRulez: Unique document library with advanced search algorithm and filtering options"/></p>
<h5><strong>3. Add your webinars to the <a href="https://gcms.labrulez.com/library">Webinar section</a></strong></h5>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_Unique_webinar_library_with_advanced_search_algorithm_and_filtering_options_3f69d949e1/LabRulez-Unique-webinar-library-with-advanced-search-algorithm-and-filtering-options.jpg" alt="LabRulez: Unique webinar library with advanced search algorithm and filtering options"/></p>
<h5><strong>4. The presentation of your offer of instrumentation, consumables or services has never been easier thanks to the <a href="https://lcms.cz/products">Products section</a></strong> (CZ version available only)</h5>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Lab_Rulez_Produkty_s_prehledem_pristroju_spotrebniho_materialu_a_sluzeb_a_moznosti_vyhledavani_a_filtrovani_07e7eb1454/LabRulez-Produkty-s-prehledem-pristroju-spotrebniho-materialu-a-sluzeb-a-moznosti-vyhledavani-a-filtrovani.jpg" alt="LabRulez: Products section with an overview of instrumentation, consumables and services and search and filtering options"/></p>
<p><strong>And much more...</strong> (Specific analytical chemistry job section or used/refurbished instruments marketplace...)</p>
<p><a href="https://labrulez.com/for-company/"><strong>Be active with us as a company</strong></a> and build your brand and awareness of your products or services.</p>
<p><a href="https://labrulez.com/for-user/"><strong>Be active with us as a user</strong></a>, share news about the results in your laboratory, add your publications to our database and build your profile and awareness of your work. </p>


+ 4,000,000 Google views in H1/2021 - LabRulez portals

<p><strong>In the week from July 19, 2021, the following webinars await you in the field of LC and LCMS.  More <a href="https://lcms.labrulez.com/webinars">details and registration can be found in the WEBINARS section.</a>:</strong></p>
<p><strong>Search and filter</strong> in more than <strong>1 000 LC and GC webinars</strong>.</p>
<h5><strong>1. Phenomenex: Core shell Performance and Phase Selectivity</strong></h5>
<p>The Core-Shell Performance Advantage. Significance of different Stationary Phase. Applications and Examples.</p>
<h5><strong>2. Phenomenex: How to do a Successful SPE Method Development &amp; Optimization</strong></h5>
<p>What to be considered? Various phases of SPE. How to run a successful SPE method. Optimizing the methods after development.</p>
<h5><strong>3. Thermo Fisher Scientific: Polar pesticides in Food: State of the Art with IC/MSMS</strong></h5>
<p>In this webinar we will present an overview of the ion chromatography (IC) solutions for polar analysis in food matrices using Mass Spectrometry.</p>
<h5><strong>4. SCION Instruments: Compass CDS: Plugins</strong></h5>
<p>In this webinar John MacKenzie reviews and demonstrates some of the Compass CDS Plugins. This is one of the strengths of the Compass, as it makes it an easier and more versatile product.</p>
<h5><strong>5. Waters Corporation: Drug Testing by LC-MS: Immunosuppressants and Antifungals</strong></h5>
<p>Topic 1: Analysis of Plasma Mycophenolic Acid for Clinical Research and Topic 2: UPLC-MS/MS Analysis of Azole Antifungals in Serum for Clinical Research.</p>
<h5><strong>6. Thermo Fisher Scientific: Highly Sensitive and Robust LC-MS/MS Solutions for Quantitation of Nitrosamine Impurities in Metformin Drug Products</strong></h5>
<p>Herein, we described LC-SRM-MS method developed using the Vanquish Horizon UHPLC coupled to a TSQ Quantis for the detection and quantitation of 10 nitrosamines in metformin drug products.</p>
<h5><strong>7. Waters Corporation: Power up your Productivity through Automation</strong></h5>
<p>This Webinar will introduce the Andrew+ Robot and OneLab Software for the preparation of standards and samples. </p>
<h5><strong>8. Technology Networks/SCIEX: Identifying Oligonucleotide Impurities and Metabolites With High-Resolution Mass Spectrometry</strong></h5>
<p>In this webinar, a novel LC-MS/MS Q-TOF instrument (ZenoTOF 7600 system, SCIEX) equipped with a patented ion trap will be applied to the acquisition of highly modified oligonucleotides.</p>
<h5><strong>9. Waters Corporation: Drug Testing by LC-MS: Oncology and Anti-Epileptic Drugs</strong></h5>
<p>Topic 1: Analysis of Methotrexate, Busulfan and 5FU from Plasma and Serum for Clinical Research and Topic 2: Rapid Analysis of Panels of Anti-Epileptic Drugs (AEDs) for Clinical Research. </p>
<h5><strong>10. Waters Corporation: Multi Reflecting Time-of-Flight Technology and its implications for the future of HRMS</strong></h5>
<p>We will cover the fundamentals of multi reflecting Time-of-Flight (MRT) and address the most asked questions since launch!</p>
<h5><strong>11. SelectScience/Thermo Fisher Scientific: Launch your lab into the future with automated LC-MS/MS</strong></h5>
<p>In this two-part webinar, hear from clinical chemistry experts Dr. Andrew Davison and Dr. Rachel Carling on why LC-MS/MS is needed to advance clinical laboratory medicine.</p>
<h5><strong>12. Agilent Technologies: High-throughput LC-MS analysis to systematically map gut microbiome drug metabolism</strong></h5>
<p>Our webinar on July 21st looks at how we can use high-throughput LC-MS analysis to systematically map the drug metabolizing capacity of the gut microbiota.</p>
<h5><strong>13. Waters Corporation: Nitrosamine Analysis (NDMA &amp; NDEA) in Raw Materials/Excipients and Finished Product by UPLC-QDa</strong></h5>
<p>We will discuss manufacturing processes to reduce impurity presence as far as possible, as well as laboratory analysis of incoming raw materials and finished product.</p>
<h5><strong>14. Waters Corporation: Persistent and mobile organic chemicals in the aquatic environment: Occurrence and analytical challenges</strong></h5>
<p>This presentation will focus on SFC by (i) highlighting methodical challenges and advantages (ii) will present several applications of SFC for analysis of PM(T) substances in environmental water samples.</p>
<h5><strong>15. SelectScience/Thermo Fisher Scientific: How to enhance productivity with an integrated compliance-ready software platform for analyses requiring chromatographic and mass spectrometric analysis</strong></h5>
<p>In this webinar Dr. Dan Bach Kristensen shares examples of how to boost productivity by using the right LC-MS software to streamline analytical workflows and enable the use of MS as a routine detector.</p>
<h5><strong>16. Agilent Technologies: Pesticides screening methodology in different food matrices using the LC/Q-TOF and MassHunter Screener Tool</strong></h5>
<p>Being a reliable partner for your lab, we endeavor to continue providing you ROBUST analytical power to deliver HIGH EFFICIENCY to enhance your PRODUCTIVITY &amp; PROFITABILITY.</p>


LC and LCMS webinars - Week 29

<p><strong>In the week from July 26, 2021, the following webinars await you in the field of LC and LCMS.  More <a href="https://lcms.labrulez.com/webinars">details and registration can be found in the WEBINARS section.</a>:</strong></p>
<p><strong>Search and filter</strong> in more than <strong>1 000 LC and GC webinars</strong>.</p>
<h5><strong>1. Agilent Technologies: The three columns of chromatography: column choice, method and care</strong></h5>
<p>The webinar will give you an overview of common column types, highlight the differences between fully and partially porous particles, and address troubleshooting in the second part.</p>
<h5><strong>2. Thermo Fisher Scientific: Intact analysis and quantitation of therapeutic proteins</strong></h5>
<p>We describe here workflows for quantitation and characterization at the intact level.</p>
<h5><strong>3. Meet the Experts - Part 6 - Compliant Ready Solution for E&amp;L Analysis</strong></h5>
<p>This webinar will give an an overview of a compliant ready solution for E&amp;L analysis featuring the Waters Xevo G2 XS QTof instrument coupled with the new waters_connect informatics platform.</p>
<h5><strong>4. Separation Science/UCT: PFAS Testing Solutions &amp; How Best to Minimize External Contamination Sources</strong></h5>
<p>Webinar in which the presenter will provide solutions for PFAS testing in line with the updated method, EPA 533 and explain what measures can be taken to mitigate external contamination sources.</p>
<h5><strong>5. Agilent Technologies: Improve your lab’s productivity with a Bidirectional LIMS and OpenLab CDS Integration</strong></h5>
<p>Being a reliable partner for your lab, we endeavor to continue providing you ROBUST analytical power to deliver HIGH EFFICIENCY to enhance your PRODUCTIVITY &amp; PROFITABILITY.</p>
<h5><strong>6. Agilent Technologies: Superior results need superior columns…Make the right choice for your GPC Application</strong></h5>
<p>Join us in this live webinar to discuss on various aspects of GPC column Selection.</p>
<h5><strong>7. Agilent Technologies: It’s Not All About the Column; Sample Prep and Containment</strong></h5>
<p>In this presentation, we will discuss sample preparation techniques; which one and when to use, to get the best chromatography, extend column lifetime, and protect your instrument.</p>
<h5><strong>8. Mestrelab Research: “Digitalize your chemistry lab”</strong></h5>
<p>The demo will cover the steps from the chemist’s first login to writing experiments, repeating them, and saving analytical data (NMR, LC, UV).</p>
<h5><strong>9. Waters Corporation: Get Prepared for Lipidomics 2.0 with Waters 2nd Edition</strong></h5>
<p>In this 2nd webinar series we will discuss some of the latest analytical approaches which have been developed to address hurdles in Lipidomics.</p>
<h5><strong>10. Agilent Technologies: Raise your Cannabis Knowledge with addition of an LC/MS IQ for Hemp Testing</strong></h5>
<p>A technical look at UV versus MS data in natural hemp products comparing results for both forms of detection.</p>
<h5><strong>11. C&amp;EN/Macmod: Analysis of Nitrosamines in APIs</strong></h5>
<p>This webinar will begin with a brief overview of nitrosamine formation. We will then focus on the development of a LC-MS/MS method for the analysis of eight targeted nitrosamines.</p>
<h5><strong>12. Bruker Daltonics: Mass Spectrometry Imaging Using Bruker timsTOF fleX with MALDI 2</strong></h5>
<p>Join our virtual Live from the Lab.</p>


LC and LCMS webinars - Week 30

<p><strong>In the week from August 2, 2021, the following webinars await you in the field of LC and LCMS.  More <a href="https://lcms.labrulez.com/webinars">details and registration can be found in the WEBINARS section.</a>:</strong></p>
<p><strong>Search and filter</strong> in more than <strong>1 000 LC and GC webinars</strong>.</p>
<h5><strong>1. Agilent Technologies: EPA 533 and EPA 537.1: Method Comparison from Sample Preparation to Quantitation</strong></h5>
<p>The Fifth Unregulated Contaminant Monitoring Rule (UCMR 5) contains 29 per- and polyfluorinated alkyl substances (PFAS) compounds to be monitored in drinking water.</p>
<h5><strong>2. Phenomenex: Latest Approaches In SPE and LC For Improving Bioanalytical Methods</strong></h5>
<p>Latest technology in sample preparation related to Bioanalytical studies, Case studies and applications, best LC solutions, HPLC column chemistries and applications in BA/BE.</p>
<h5><strong>3. Thermo Fisher Scientific: The future of oligonucleotide analysis, from short synthetic DNA to mRNA sequencing</strong></h5>
<p>The oligonucleotide field may be mature but there have been significant advances in sample preparation, chromatography, mass spectrometry and software to match the advances in oligonucleotide therapeutics.</p>
<h5><strong>4. Waters Corporation: Save Time and Money with Waters Session 1: Series Welcome and Scientist Education Made Simple</strong></h5>
<p>We will hear from James Bulgarelli, Customer Education Manager, about how an Education Subscription can save you from reduced lab productivity and enhance staff education.</p>
<h3><a href="https://lcms.labrulez.com/webinars?tags=15"><strong>LC and LCMS Webinars: Tips &amp; Tricks (66)</strong></a></h3>
<ul>
<li><p><strong>Agilent Technologies: HPLC Connections — Fittings and Flow Path</strong> (We, 22.9.2021, 17:00 (CEST - Prague))</p>
</li>
<li><p><strong>Waters Corporation: Chromatography Declassified: Uncovering the Secrets of Method Robustness Part 3</strong> (Tu, 5.10.2021, 08:00 (CEST - Prague))</p>
</li>
<li><p><strong>Agilent Technologies: Troubleshooting Fundamentals</strong> (Th, 7.10.2021, 17:00 (CEST - Prague))</p>
</li>
<li><p><strong>Agilent Technologies: It’s Not All About the Column; Sample Prep and Containment</strong> (Already taken place We, 28.7.2021)</p>
</li>
<li><p><strong>Phenomenex: HPLC Troubleshooting — Identifying, Solving and Avoiding Problems</strong> (Already taken place Tu, 13.7.2021)</p>
</li>
<li><p><strong>Separation Science/Waters Corporation/Hichrom: What It Takes to Achieve a Good Chromatography – Selecting the Right Column Chemistries and Mobile Phase</strong> (Already taken place Tu, 13.7.2021)</p>
</li>
<li><p><strong>Waters Corporation: Our favorite productivity tools for staying ahead in LC-MS/MS food testing workflows</strong> (Already taken place Tu, 22.6.2021)</p>
</li>
</ul>
<p>And almost 60 other webinars focused on <a href="https://lcms.labrulez.com/webinars?tags=15"><strong>Tips &amp; Tricks in LC a LCMS</strong></a> available in the database.</p>


LC and LCMS webinars - Week 31 + LC and LCMS Tips & Tricks

<p><strong>In the week from August 9, 2021, the following webinars await you in the field of LC and LCMS.  More <a href="https://lcms.labrulez.com/webinars">details and registration can be found in the WEBINARS section.</a>:</strong></p>
<p><strong>Search and filter</strong> in more than <strong>1 000 LC and GC webinars</strong>.</p>
<h5><strong>1. Shimadzu Corporation: Let&#39;s Protect Our Health With Herbs! Analytical Insights into Herbal Medicine</strong></h5>
<p>In this webinar, we will discuss the vital role of analytical instrumentations in developing safe herbal medicine products, as well as the need for these advanced techniques in quality control process.</p>
<h5><strong>2. Phenomenex: Sample Preparation Strategies for LC-MS/MS Analysis of Drugs in Difficult Matrices</strong></h5>
<p>Sample preparation of whole blood, serum, and urine matrix clean-up comparisons for chromatography and LC-MS/MS.</p>
<h5><strong>3. Agilent Technologies: Mitigating Risk of Mutagenic Impurities – A comprehensive approach to analyze trace level Nitrosamines</strong></h5>
<p>Agilent and Milli-Q® Lab Water Solutions from Merck brings its renowned expertise to answer the toughest questions on Mitigating Risk of Mutagenic Impurities - Nitrosamines.</p>
<h5><strong>4. Waters Corporation: Medical Device Webinar Series Part 4: Strategies for Screening of Non-volatile Extractable and Leachable Compounds</strong></h5>
<p>In this talk, we will examine the necessary criteria for compound identification and how a general screening method and library of known compounds can aid in extractables and leachable testing.</p>
<h5><strong>5. Agilent Technologies: Structural Characterization of Biopolymers by GPC/SEC Coupled to Special Detectors (ELSD, Viscometer, Light Scattering)</strong></h5>
<p>This webinar explores a basic introduction regarding biopolymers and a detailed discussion on characterization techniques via GPC/SEC, as well as the potential of adding advanced detection technologies.</p>
<h5><strong>6. Phenomenex: Chromatographic Techniques For Characterization of Recombinant Biomolecules – Antibodies &amp; Oligonucleotides</strong></h5>
<p>Size Exclusion, Widepore reverse phase, Narrow pore reverse phase, HILIC, Ion Exchange, High pH reverse phase, Nano LC techniques.</p>
<h5><strong>7. C&amp;EN/Agilent Technologies/Jordi Labs: A Multidetector Approach to Reduce Uncertainty in Extractable and Leachable Analysis and Drug Impurity Characterization</strong></h5>
<p>In this webinar, a multidetector approach for quantitation using the combined strengths of LC/QQQ and UV and CAD as well as GC/MS with simultaneous FID will be presented.</p>


LC and LCMS webinars - Week 32

<p><strong>In the week from August 16, 2021, the following webinars await you in the field of LC and LCMS.  More <a href="https://lcms.labrulez.com/webinars">details and registration can be found in the WEBINARS section.</a>:</strong></p>
<p><strong>Search and filter</strong> in more than <strong>1 000 LC and GC webinars</strong>.</p>
<h5><strong>1. SelectScience/Agilent Technologies: Automated process monitoring via liquid chromatography (LC)</strong></h5>
<p>You will learn about an online LC platform for automated sample analysis via direct injections or retained samples from flow reactors, batch reactors, upstream bioreactors and downstream purification devices.</p>
<h5><strong>2. Phenomenex: HPLC Column Care &amp; Extending Column Lifetimes</strong></h5>
<p>HPLC columns are major consumables in HPLC analysis, therefore protecting them would be of a prime consideration.</p>
<h5><strong>3. Agilent Technologies: Too Polar for Reverse Phase: What Do You Do?</strong></h5>
<p>We will try to present general guidelines on how to choose the right separation mode (HILIC or RP). Working down a checklist, we will discuss aspects that have to be taken into consideration.</p>
<h5><strong>4. Phenomenex: Method Development In Flash Purification</strong></h5>
<p>We will cover solutions, applications, various instruments and method development by using flash chromatography.</p>
<h5><strong>5. GERSTEL: Driving Efficiency by Automating Sample Preparation Techniques</strong></h5>
<p>We will talk about Automating Sample Preparation Techniques in your laboratory.</p>
<h5><strong>6. Agilent Technologies: Accurate and Simple Quantification of THC and CBD in Beverages Containing Microemulsions</strong></h5>
<p>In this short webinar, you will learn how to avoid the most common pitfalls when performing potency testing in beverages.</p>
<h5><strong>7. SCION Instruments: DAD - Impurity/Profiling workflows</strong></h5>
<p>Introduction into the LC6000; profiling workflows and calculating peak impurity using LC - Diode Array Detection (DAD).</p>
<h5><strong>8. SelectScience/Restek Corporation: Easy, rapid and direct analysis of challenging polar compounds</strong></h5>
<p>Connor Flannery will highlight specific application examples that will illustrate the rapid and direct analysis of underivatized amino acids, ultrashort-chain PFASs, glyphosate, and other polar contaminants.</p>
<h5><strong>9. Phenomenex: Sample preparation options available for HPLC analysis in Pharmaceutical industry</strong></h5>
<p>Overview of available sample prep solutions for Pharmaceutical industry . To know various sample preparation options and how to implement during the HPLC analysis.</p>


LC and LCMS webinars - Week 33

<p><strong>In the week from August 23, 2021, the following webinars await you in the field of LC and LCMS.  More <a href="https://lcms.labrulez.com/webinars">details and registration can be found in the WEBINARS section.</a>:</strong></p>
<p><strong>Search and filter</strong> in more than <strong>1 000 LC and GC webinars</strong>.</p>
<h5><strong>1. Phenomenex: Size Exclusion Chromatography: How to Select an SEC Column and Optimize a Method</strong></h5>
<p>Accurate characterization of monoclonal antibody (mAb) aggregates has huge significance in the development of new therapeutic agents. Selection of SEC column and optimizing method place a crucial role.</p>
<h5><strong>2. Waters Corporation: Save Time and Money with Waters Session 4: MaxPeak HPS Technology and the Contract Organization: Stand Out from the Competition</strong></h5>
<p>You will learn how implementing Waters’ MaxPeak HPS technology in your sample vials and plates, columns and LC systems can improve your lab’s efficiency from sample preparation to data analysis.</p>
<h5><strong>3. Phenomenex: Method Robustness and Transferability for Modern Size Exclusion Methods</strong></h5>
<p>Understand the impact of HPLC/UHPLC systems on obtaining robust and reproducible aggregate analysis data by SEC and determine the experimental parameters to vary to ensure analytical method robustness.</p>
<h5><strong>4. SelectScience/Agilent Technologies: The Agilent and Atturos pathway for the development of targeted biomarker measurements for precision medicine</strong></h5>
<p>Our experts outline the significant clinical need for better chronic disease testing and explain how this need can be met through a simplified, robust, reproducible, and cost-effective analysis of samples.</p>
<h5><strong>5. Waters Corporation: Medical Device Webinar Series Part 5: Chemical Characterization of Medical Device Materials – An Analytical Laboratory Perspective</strong></h5>
<p>In overview of analytical methods used for chemical characterization of materials used in medical devices will be presented.</p>
<h5><strong>6. Agilent Technologies: InfinityLab Online LC Solutions: Introducing a Wealth of new Features and Tools for Chromatographers and Process Chemists</strong></h5>
<p>The Agilent 1260 Infinity II Prime Online LC dedicated system for process monitoring is based on the all-new Agilent 1260 Infinity II Online Sample Manager Interface to the “Process World”.</p>
<h5><strong>7. Phenomenex: Flash Chromatography - From Principle to Optimization</strong></h5>
<p>Join us, receive a certificate of completion, and a free method consultation with one of our technical expert!</p>
<h5><strong>8. Shimadzu Corporation: Safe, Simple, and Practical: Meeting the Specific Demands of Pharmaceuticals and Packaging</strong></h5>
<p>Start ensuring the quality of pharmaceutical products and packaging with Shimadzu today – with compact and high-performing machines.</p>
<h5><strong>9. Evosep Biosystems: Targeted workflows with Evosep One</strong></h5>
<p>In this webinar, we will explore the possibilities of using the Evosep One for targeted workflows.</p>
<h5><strong>10. Separation Science/SCIEX: Dilution and Sensitivity: Effects on a Food Contaminant Mega-Method</strong></h5>
<p>Webinar explores how far we can push dilution while still meeting sensitivity requirements to simplify sample preparation and analysis workflows when it comes to contaminant testing in foodstuffs.</p>
<h5><strong>11. Agilent Technologies: Is 2D HPLC the Answer for You?</strong></h5>
<p>In this presentation, we’ll talk about the approaches to 2D HPLC, comprehensive and heart-cutting (single and multiple).</p>


LC and LCMS webinars - Week 34

<p><strong>In the week from August 23, 2021, the following webinars await you in the field of LC and LCMS.  More <a href="https://lcms.labrulez.com/webinars">details and registration can be found in the WEBINARS section.</a>:</strong></p>
<p><strong>Search and filter</strong> in more than <strong>1 000 LC and GC webinars</strong>.</p>
<h5><strong>1. Waters Corporation: Save Time and Money with Waters Session 5: Automation Strategies to Save Time and Money</strong></h5>
<p>We introduce a simple, smart automation solution and present a real example of cost and time savings. We will also take you through a tour of OneLab software.</p>
<h5><strong>2. Agilent Technologies: Agilent Profinder: Best Practices for Non-Targeted Small Molecule Experiments</strong></h5>
<p>This webinar will focus on Profinder 10 and how this software program is crucial to a scientist’s workflows in small molecule big data applications. </p>
<h5><strong>3. SelectScience/Thermo Scientific: Beyond glyphosate: Trace-level analysis of highly polar pesticides in foods</strong></h5>
<p>We will discuss how pesticides can be separated into their native ionic form on an ion-exchange column, and how this enables the quantification of polar pesticides by MS/MS for hundreds of injections.</p>
<p>V týdnu <a href="https://lcms.labrulez.com/webinars"><strong>od 6. Září</strong> na Vás zatím čeká <strong>9 LC a LCMS Webinářů</strong></a>.</p>


LC and LCMS webinars - Week 35

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The Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences (IOCB Prague) is a leading scientific institution in the Czech Republic, recognized internationally. Its primary mission is basic research in the fields of chemical biology and medicinal chemistry, organic and material oriented chemistry, chemistry of natural compounds, biochemistry and molecular biology, physical chemistry, theoretical chemistry, and analytical chemistry. 

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

My main interest is the identification of organic compounds by mass spectrometry in organic mixtures.

LC and LCMS webinars - Week 35

LC and LCMS webinars - Week 34

LC and LCMS webinars - Week 33

LC and LCMS webinars - Week 32

LC and LCMS webinars - Week 31 + LC and LCMS Tips & Tricks

LC and LCMS webinars - Week 30

LC and LCMS webinars - Week 29

+ 4,000,000 Google views in H1/2021 - LabRulez portals

LC/MS Unknown Identifications Using MSMS Libraries Part VIII: Identification of Unknowns with “Spectraless” Libraries

Prague Meeting on Historical Perspectives of Mass Spectrometry - Early registration!

Upcoming events

Bruker at SOFT-TIAFT 2026

Thermo Fisher Scientific at SOFT/TIAFT 2026

Thermo Fisher Scientific Environmental & Food Safety Workshop Series 2026

Webinars

The Next Frontier in Nitrosamines Testing: Detection and Risk Assessment in Packaging and IV Infusion Bags

Membrane Technologies for Water and Food Sustainability

Unlocking Lab Productivity: Automation Opportunities for LC/MS Laboratories