Forced degradation analysis of recombinant adeno-associated virus serotype 8 based on analytical anion exchange chromatography coupled to orthogonal characterization
LCMSScientific article | Science and research

Forced degradation analysis of recombinant adeno-associated virus serotype 8 based on analytical anion exchange chromatography coupled to orthogonal characterization

An analytical AEX workflow with orthogonal characterization reveals distinct pH-dependent degradation pathways of rAAV8 during accelerated storage.
Forced degradation analysis of recombinant adeno-associated virus serotype 8 based on analytical anion exchange chromatography coupled to orthogonal characterization
News from LabRulezLCMS Library - Week 35, 2026
LCMSArticle | Application

News from LabRulezLCMS Library - Week 35, 2026

This week we bring you application notes by Agilent Technologies, Thermo Fisher Scientific, Shimadzu and Waters Corporation!
News from LabRulezLCMS Library - Week 35, 2026
A Liquid–Liquid Extraction Method for Measuring Ultrashort PFCAs and Longer-Chain PFAS in Water
LCMSScientific article | Science and research

A Liquid–Liquid Extraction Method for Measuring Ultrashort PFCAs and Longer-Chain PFAS in Water

A two-stage liquid–liquid extraction method enables sensitive, reproducible analysis of ultrashort PFCAs such as TFA and longer-chain PFAS in water.
A Liquid–Liquid Extraction Method for Measuring Ultrashort PFCAs and Longer-Chain PFAS in Water
Stability-Indicating HPLC-UV Method for Semaglutide Impurity Analysis
LCMSArticle | Application

Stability-Indicating HPLC-UV Method for Semaglutide Impurity Analysis

Discover a stability-indicating HPLC-UV method for semaglutide impurity analysis using the Vanquish Flex UHPLC system and Hypersil GOLD Peptide column.
Stability-Indicating HPLC-UV Method for Semaglutide Impurity Analysis
News from LabRulezLCMS Library - Week 32, 2026
LCMSArticle | Poster

News from LabRulezLCMS Library - Week 32, 2026

This week we bring you posters by Agilent Technologies / ASMS, Shimadzu / ASMS, Thermo Fisher Scientific / HPLC and Waters Corporation / ASMS and application note by Metrohm!
News from LabRulezLCMS Library - Week 32, 2026
Modernizing Routine HPLC Methods: Aligning Productivity, Compliance, and Sustainability
LCMSArticle | Science and research

Modernizing Routine HPLC Methods: Aligning Productivity, Compliance, and Sustainability

How can laboratories modernize legacy HPLC methods while remaining compliant? Learn how Opella leveraged UHPLC and evolving regulatory guidance to boost productivity.
Modernizing Routine HPLC Methods: Aligning Productivity, Compliance, and Sustainability
How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors
LCMSArticle | Academy

How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors

Discover how online SPE combined with UHPLC accelerates hop bitter acid analysis, reduces solvent consumption, and delivers reliable data for better beer flavor control.
How Bitter Acid Analysis Helps Brewers Better Control Beer Flavors
Untargeted Metabolomics Identifies N-Lactoyl-Amino Acids as Dose-Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes
LCMSScientific article | Science and research

Untargeted Metabolomics Identifies N-Lactoyl-Amino Acids as Dose-Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes

This study identifies N-lactoyl-amino acids as plasma biomarkers that accurately reflect metformin exposure and treatment adherence in T2D.
Untargeted Metabolomics Identifies N-Lactoyl-Amino Acids as Dose-Responsive Plasma Biomarkers of Metformin Adherence in Type 2 Diabetes
Monitoring mAb Manufacturing the Easy Way with Switchable 2D‑LC-UV-MS
LCMSArticle | Science and research

Monitoring mAb Manufacturing the Easy Way with Switchable 2D‑LC-UV-MS

How can mAb manufacturing monitoring be simplified? Switchable 2D-LC-UV-MS workflows enable near real-time tracking of critical quality attributes and faster process decisions.
Monitoring mAb Manufacturing the Easy Way with Switchable 2D‑LC-UV-MS
Characterisation of small RNA-based therapeutics and their process impurities by fast and sensitive liquid chromatography high resolution mass spectrometry
LCMSScientific article | Science and research

Characterisation of small RNA-based therapeutics and their process impurities by fast and sensitive liquid chromatography high resolution mass spectrometry

This study presents a sensitive LC-HRMS method for sequence verification and impurity profiling of RNA-based therapeutics.
Characterisation of small RNA-based therapeutics and their process impurities by fast and sensitive liquid chromatography high resolution mass spectrometry