<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 17th August 2026? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you posters by <strong>Agilent Technologies / ASMS, Thermo Fisher Scientific / ASMS </strong>and<strong> Shimadzu / ASMS </strong>and application note by<strong> Waters Corporation!</strong></p><h3><strong>1. Agilent Technologies / ASMS: Quantitation of N-Nitroso Duloxetine N-Nitrosamine Drug Substance Related Impurities (NDSRI) in API and Formulation by 6475 LC/TQ</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_drug_impurities_lc_tq_tp_402_asms_2026_en_agilent_b933b9bddf.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Nitrosamine impurities are nitroso derivatives where the nitroso group is attached to an amine. The active pharmaceutical ingredient (API) derived from a class of nitrosamines are known as N-nitrosamine drugsubstance-related impurities (NDSRI). Nitrosamine impurities in APIs and drug products pose safety concerns, even in small quantities, and thus are a major concern for drug makers [1].&nbsp;</p><p>Analytical methods must be sufficiently sensitive to quantify the nitrosamine of interest at levels as low as 10% of the specification limit and, where feasible, down to ≤5% of the specification limit, for the determination of the limit of detection. LC/MS/MS is an inherently selective and highly sensitive analytical technique that is well suited for the identification and quantification of trace-level impurities at extremely low concentrations. Consequently, LC/MS/MS has been widely adopted within the pharmaceutical industry, particularly for nitrosamine analysis [2-3].&nbsp;</p><p>Therefore, manufacturers must develop and qualify a dedicated analytical method that is appropriate for the specific sample matrix and targeted NDSRIs. An LC/MS/MS method based on multiple reaction monitoring (MRM) was developed for the detection and quantification of the N-nitroso duloxetine NDSRI impurity over a concentration range of 0.5 to 40 ppb (absolute standard concentration), using an atmospheric pressure chemical ionization (APCI) source on an Agilent 6475A LC/TQ instrument.</p><h4><strong>Experimental</strong></h4><ul><li><strong>MS:</strong> <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=10&amp;search=6475"><strong>6475 Triple Quadrupole LC/MS System</strong></a></li><li><strong>Column:</strong> <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=10&amp;search=Poroshell+HPH+C18"><strong>Poroshell HPH C18</strong></a> (4.6*150mm, 2.7µm)</li></ul><h4><strong>Conclusions</strong></h4><ul><li>A highly sensitive and robust MRM LC/MS/MS method was developed for the quantitation of N-nitroso duloxetine in duloxetine hydrochloride API and finished formulation using the Agilent 6475A LC/TQ.&nbsp;</li><li>The optimized chromatographic conditions provided effective separation of the analyte from the API, placebo, and formulation matrices, ensuring reliable quantitation.&nbsp;</li><li>The calibration curve was linear over the concentration range of 0.5-40 ng/mL, with 1/x weighting. R and R2 values were observed for both to be greater than 0.99.&nbsp;</li><li>Recovery studies demonstrated efficient sample extraction, with recoveries ranging from 92-99% in API samples and 109-116% in pellet formulations at the LOQ, specification, and 200% specification levels.&nbsp;</li><li>The method also showed excellent reproducibility across all evaluated concentration levels, confirming its suitability for routine analysis.</li></ul><h3><strong>2. Shimadzu / ASMS: Non-Targeted Analysis of Per- and Polyfluoroalkyl Substances in Environmental Extracts by Microflow LC-QToF Coupled with Multi-spray ESI</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/TP_562_Non_Targeted_Analysis_of_Per_and_Polyfluoroalkyl_Substances_in_Environmental_Extracts_by_Microflow_LC_Q_To_F_Coupled_with_Multi_spray_ESI_c2a7e1d5bf.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Targeted screening methods are well established for monitoring Perand polyfluoroalkyl substances (PFAS) in environmental samples. However, PFAS comprise a large and evolving class of compounds, creating a need to screen existing, emerging, and transformation products across diverse matrices. Non-targeted Analysis (NTA) allows for the confirmation of suspected PFAS in the environment, but the sample characterization is often limited by analytical sensitivity. Microflow (0.5 – 40 µL/min) coupled with a multi-nozzle emitter enhances sensitivity by improving desolvation. When this is coupled to a high mass accuracy and resolution Quadrupole Time-ofFlight Mass Spectrometer (QToF), capable of data-dependent and independent MS/MS, PFAS characterization of unknown analytes is possible. In this study, various environmental extracts were processed and screened using NTA for PFAS compounds.</p><h4><strong>Methods</strong></h4><p>A <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=1&amp;search=Nexera+Mikros"><strong>Shimadzu Nexera Mikros LC</strong> </a>was used to introduce the sample to a Newomics DuoESI source with an M3 emitter on a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=1&amp;search=9050"><strong>LCMS-9050 QToF MS</strong></a> (Fig. 1). A direct injection on an octadecyl column without delay column was performed. Direct injection was chosen over trapand-elute configuration to minimize selectivity bias caused by the trap column.&nbsp;</p><h4><strong>Conclusion</strong></h4><p>With the increased sensitivity of microflow LC-QToF coupled with multi-spray ESI with DIA acquisition, Insight Explore aided in NTA PFAS analysis. When paired with Insight Discovery and Profiler, a streamlined batch data processing workflow with statistical analysis was shown to effectively handle complex environmental matrices and their analyses.</p><h3><strong>3. Thermo Fisher Scientific / ASMS: Robust and sensitive quantitation of 18 steroids in human serum using Thermo Scientific TSQ Certis Triple Quadrupole mass spectrometer</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/po_004707_lsms_18_steroids_tsq_certis_clinical_po004707_asms2026_na_en_244c52437b.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Accurate quantification of endogenous steroids in human serum is essential for biomonitoring physiological functions such as hormone regulation, reproduction, and immune response in clinical research laboratories. Liquid chromatography–tandem mass spectrometry (LC–MS/MS) is the gold standard for steroid analysis due to its superior sensitivity, selectivity, and multiplexing capability compared to immunoassays. However, steroid measurements remain challenging because of low endogenous concentrations and complex serum matrices. Here, we describe a robust and sensitive LC–MS/MS method for the simultaneous quantification of 18 steroids in human serum using the Thermo Scientific TSQ Certis triple quadrupole mass spectrometer (Figure 1). The method leverages advanced ion source design and fast acquisition to deliver enhanced sensitivity, stability and throughput suitable for high-volume laboratory workflows.</p><h4><strong>Materials and methods</strong></h4><h5><strong>Liquid chromatograph – mass spectrometry&nbsp;</strong></h5><p>Samples were analyzed on a <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/744"><strong>Thermo Scientific Vanquish Horizon UHPLC system</strong></a> coupled to the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2207"><strong>TSQ Certis MS</strong></a><strong> </strong>operated in selected reaction monitoring (SRM) mode. The mobile phase composition, analytical column details, LC gradient, and overlaid extracted ion chromatograms (EICs) are shown in Figure 3.&nbsp;</p><h5><strong>Data analysis&nbsp;</strong></h5><p>Data were acquired and processed using <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/77"><strong>Thermo Scientific TraceFinder software</strong></a> (v 5.2).</p><h4><strong>Conclusions&nbsp;</strong></h4><p>A sensitive and robust LC–MS/MS method was developed for simultaneous quantification of 18 steroids in human serum using the Vanquish Horizon UHPLC and TSQ Certis MS with OptaMax Plus ion source. The method demonstrated excellent linearity, accuracy, and reproducibility across a wide dynamic range. Optimization of MS conditions, particularly vaporizer temperature, significantly improved sensitivity. Overall, the workflow delivers high sensitivity, selectivity, and long-term stability, providing a reliable solution for high-throughput steroid analysis in clinical and research settings.</p><h3><strong>4. Waters Corporation: Alkaline-hydrolysis Method for PFAS in Textiles and Textiles Products by Xevo™ TQ-S micro with ACQUITY™ UPLC™ H-Class Plus System</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720009443_en_0ab4914d72.pdf"><strong>Full PDF for download</strong></a></li></ul><div><div><section><div><div><div><div><div><div><h5><strong>Benefits&nbsp;</strong></h5><ul><li>Alkaline hydrolysis method (EN 17681-1:2025) used for preparing textiles, coated textiles and textile products for PFAS analysis allowed the inclusion of side-chain fluorinated polymers&nbsp;</li><li>Extraction method provided significant advantages in handling complex textile matrices by creating clear extracts free from dispersions, settleable solids and particulates&nbsp;</li><li>Protected the high-value LC-MS/MS components from potential damage&nbsp;</li><li>The method improved analytical sensitivity, reproducibility and accuracy, enabled cost-effective and timeefficient PFAS analysis maintained high analytical quality even for challenging high-matrix samples</li></ul><p>Many PFAS are linked to health concerns because of their ability to interfere with the body’s hormone systems, acting as endocrine disruptors also, linked to other toxic effects. Since textiles come into direct and prolonged contact with the skin, there is an increased risk of human exposure—especially for babies and children.4 In addition, PFAS pose significant environmental concerns. These “forever chemicals” do not readily break down and can be released during manufacturing, washing and disposal, allowing them to enter water pathways and persist in the environment. As a result, testing for PFAS has become increasingly important in the textile industry to demonstrate supply chain transparency, build consumer trust and protect brand reputation.</p><p>Synthetic fluorinated chemicals are categorized into two main groups - non-polymeric PFAS and polymeric PFAS, known for their use as water and grease repellent, heat resistant finishes in textiles, upholstery, leather, apparel, carpet and other industrial applications such as packaging, firefighting foams, non-stick cookware, etc. (Figure 1). PFAS are fluorinated substances contain at least one fully fluorinated methyl or methylene carbon atom (without any H/Cl/Br/I atom attached to it), i.e. with a few noted exceptions, any chemical with at least a perfluorinated methyl group or a perfluorinated methylene group.2 PFAS are classified as long chain and short chain based on their perfluorinated carbon chain length. Short chain fluorinated polymers encompasses a diverse range of chemistries, categorized according to their generic chemical and repeating units structures. Few examples are: derivatives of fluorotelomers, perfluoropolyethers with varying carbon chain lengths and acrylates, epoxylates, urethane, silicones of repeated units based structures.3 Polyfluoroalkyl substances such as fluorotelomer alcohols (FTOHs) contain C–H bonds, rendering them more susceptible to degradation. The ethoxylates in fluorotelomers-methacrylate break down to FTOH whereas polymeric fluorinated urethanes, acrylates break down to PFCAs (non-polymeric and polymeric side chain fluorinated polymers). In contrast, perfluoroalkyl substances such as PFOS and PFOA are extremely persistent due to their fully fluorinated carbon chains.&nbsp;</p><p>In alkaline hydrolysis methods, methanolic aqueous sodium hydroxide is used to break down precursor PFAS such as FTOHs, branched side chain PFAS. This process releases terminal perfluorinated carboxylic acids (PFCAs), which can then be measured. However, the efficiency of hydrolysis varies among different PFAS compounds and the presence of interfering substances such as organic matter or other chemicals in the sample matrix can inhibit the cleavage and detection of these analytes.</p><h4><strong>Experimental</strong></h4><ul><li><strong>LC system:</strong> <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/198"><strong>ACQUITY UPLC H-Class Plus System</strong></a> and SMFTN fitted with PFAS kit</li><li><strong>Column(s):</strong> <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1823"><strong>XBridge™ BEH™ C18 5 µm Column</strong></a>, 4.6 x 100 mm&nbsp;</li><li><strong>MS system: </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/209"><strong>Xevo TQ-S micro Mass Spectrometer</strong></a></li></ul><h4><strong>Conclusion&nbsp;</strong></h4><p>By strictly following the critical steps of the alkaline hydrolysis method using methanolic aqueous sodium hydroxide (NaOH) both freely extractable PFAS and those previously bound within side-chain fluorinated polymers such as esters linked to fluorotelomer alcohols (n:2 FTOHs, where n = 4, 6, 8, 10, 12), can be effectively extracted. This approach also safeguards the LC-MS/MS instrumentation from blockages, damage, or contamination by preventing polymer accumulation and matrix interferences.&nbsp;</p><p>The analytical method using the ACQUITY UPLC H-Class Plus System and Xevo TQ-S micro LC-MS/MS System was found to be sensitive, reproducible and accurate, enabling cost-effective and time-efficient PFAS analysis in chemically processed textiles, coated textiles and textile products whilst maintaining high analytical quality even for challenging high-matrix samples.</p></div></div></div></div></div></div></section></div></div>

News from LabRulezLCMS Library - Week 34, 2026

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 17th August 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies,</strong> <strong>Metrohm</strong>, and <strong>Shimadzu </strong>and other document by <strong>Thermo Fisher Scientific!</strong></p><h3><strong>1. Agilent Technologies: Direct Analysis of Seawater Using ICP-QQQ and Integrated Advanced Valve System</strong></h3><p><strong>Fast, robust environmental analyses using an </strong><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=9500"><strong>Agilent 9500 ICP-QQQ</strong></a><strong> with AVS MS&nbsp;</strong></p><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_seawater_9500_icp_qqq_5994_8988en_agilent_e56319c80a.pdf"><strong>Full PDF for download</strong></a><strong>&nbsp;</strong></li></ul><p>Trace elements in seawater play a vital role in marine biogeochemical cycles, influencing ocean productivity, ecosystem health, and global climate regulation.1,2 Although present at extremely low concentrations, many trace elements are essential for biological processes, while others, including heavy metals, serve as indicators of contamination from industrial activities and coastal development. Accurate determination of a wide range of elements is therefore critical for environmental monitoring, oceanographic research, and regulatory compliance. EPA Method 200.8 provides a widely adopted quality control (QC) framework for trace metal analysis in natural waters.3 However, seawater’s high salinity and major components such as Na, Mg, Cl, and S create analytical challenges for conventional ICP-MS analysis, including ionization suppression and polyatomic interferences, such as ArCl+ on As, ArNa+ on Cu, SO2 + on Zn. Overcoming these issues requires advanced interference removal techniques and high sensitivity. Triple quadrupole ICP-MS (ICP-QQQ) addresses these limitations through its MS/MS configuration.</p><p>Agilent ICP-MS/MS methods precisely control reaction chemistry and eliminate interferences, ensuring accurate quantification in complex saline matrices.&nbsp;</p><p>The Agilent 9500 Triple Quadrupole ICP-MS with its unique Dual-Cell System (DCS) enables accurate, efficient seawater analysis using enhanced collision/reaction cell (CRC) technologies. Its performance is primarily driven by Advanced Helium Mode (AHM). This advanced collision mode delivers exceptional on-mass interference removal using a combination of Kinetic Energy Discrimination (KED) and Collision Induced Dissociation (CID), ensuring precise quantification even in highly saline and complex matrices.4 Additionally, Air cell mode enables fast, effective mass-shift reactions, adding flexibility for overcoming challenging interferences.5 By seamlessly integrating AHM with Air cell mode, the 9500 simplifies workflows and delivers reliable results for trace analysis of multiple elements in seawater.</p><p>&nbsp;In this study, a <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=10&amp;search=9500"><strong>9500 ICP-QQQ</strong></a> fitted with the AVS MS was used to quantify 26 elements in two seawater certified reference materials (CRMs) and a sample collected in Singapore, employing an online reverse-dilution approach. The method was assessed following the performance requirements of EPA Method 200.8.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>Traditional seawater analysis by ICP‑MS often requires extensive sample preparation, such as dilution and matrix separation, to address high salinity and complex matrix effects. These additional steps increase both turnaround time and contamination risk. The method developed here enables direct seawater analysis using an online reverse-dilution approach, eliminating manual preparation and enabling rapid, high-throughput processing. Using the Agilent 9500 ICP-QQQ with AVS MS in online dilution mode, the workflow achieved ppt-level MDLs for 26 elements, excellent accuracy (90–110% recoveries for CRMs and spiked samples), and long-term stability across more than 130 analyses, meeting EPA Method 200.8 QC requirements.&nbsp;</p><p><strong>Key advantages of the 9500 ICP-QQQ method:&nbsp;</strong></p><ul><li><strong>Effective interference removal: </strong>Advanced gas modes (AHM and Air cell mode) controlled polyatomic species originating from the high-salinity matrices.&nbsp;</li><li><strong>High throughput:</strong> Automated online dilution and seamless gas-switching enabled complete analysis in 140 seconds per sample.&nbsp;</li><li><strong>Robust stability: </strong>Optimized rinse protocols ensured consistent ISTD recovery and instrument performance over a seven-hour run comprising 100 injections of undiluted seawater samples.&nbsp;</li></ul><p>This workflow delivers fast, reliable, and high-quality seawater analysis, making it ideal for environmental monitoring and marine research laboratories seeking maximum efficiency without compromising data integrity.</p><h3><strong>2. Metrohm: Moisture and protein content in corn starch with NIR spectroscopy</strong></h3><p><strong>Easily measure the quality of corn starch in seconds with NIR</strong></p><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_nir_151_download_087f0d33e0.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Starch is a fundamental component in candy production where it is often used as a gelling agent and thickener. The confectionery industry uses it to create products with a certain consistency, like pie fillings. It is also used in a process known as starch molding where shapes are pressed into a corn starch bed for gummy candies and similar treats. Corn starch also acts as a desiccant during the candies' drying process before reuse. Therefore, the corn starch moisture content is a very important factor to consider in this process.&nbsp;</p><p>Near-infrared spectroscopy (NIRS) is a fast, chemicalfree analysis technique for the determination of moisture content and corn protein content in corn starch. The NIRS solution is easy to use and can be used either atline or in a quality control laboratory.</p><h4><strong>EXPERIMENTAL EQUIPMENT&nbsp;</strong></h4><p>210 samples of corn starch were measured with an <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library?mainauthorItems=220&amp;search=OMNIS+NIR"><strong>OMNIS NIR Analyzer Solid</strong></a> (Figure 1). All measurements were performed in reflection mode (1000–2250 nm) using a large holder and large cup (Table 1). OMNIS Software was used for all data acquisition and prediction model development. Karl Fischer titration was used to determine the water content in corn starch, and the Kjeldahl method was used to determine its protein content.</p><h4><strong>CONCLUSION</strong></h4><p>This Application Note shows the feasibility of using near-infrared spectroscopy for the determination of moisture and protein content in corn starch. Compared to the conventional analysis techniques used to determine these quality parameters, NIRS saves a considerable amount of time and costs. With NIR spectroscopy, analyses can be conducted without using any chemical reagents, giving users reliable results in seconds.</p><h3><strong>3. Shimadzu: Observation of Crack Propagation Process in Aluminum Alloy Specimen Using Air-Servo Microfocus X-Ray CT System</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/an_01_01152_en_de411e6e13.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User benefits</strong></h5><ul><li>The Air-Servo Microfocus X-Ray CT System enables observation of crack propagation in three dimensions and over time.</li><li>Microfocus X-Ray CT system enables nondestructive observation of the interior of materials.</li><li>High-precision dynamic control is possible with the Servo Controller 4830.</li></ul><p>Many structural failures are caused by fatigue failure resulting from repeated loading. In fatigue failure, cracks initiate from microdefects in the material, internal voids, inclusions, and other features, and then propagate under repeated loading until final fracture occurs. To evaluate this sequence of processes, it is effective to observe defects and crack propagation nondestructively.&nbsp;</p><p>Traditionally, crack observation has focused on visual inspection and microscopic observation, but these methods are limited to information near the surface. To sufficiently capture the threedimensional shape and changes in cracks propagating inside a material, observation of the fractured specimen after failure has generally been used. In contrast, X-ray CT can nondestructively visualize internal defects and cracks in three dimensions, making it possible to evaluate in detail changes in crack morphology, including in the interior.&nbsp;</p><p>Accordingly, using the “Air-Servo Microfocus X-Ray CT System,” which combines X-ray CT with a fatigue testing machine, repeated tests were performed in which loading was stopped at fixed cycle intervals and imaging was carried out. This article introduces the resulting process of crack initiation and propagation in the same specimen.</p><h4><strong>Conclusion</strong></h4><p>Using the Air-Servo Microfocus X-Ray CT System, cracks propagating from the notch region of an aluminum alloy specimen were observed. First, static tests and fatigue tests were performed using the servo pulser EHF-LV, and a S-N diagram was obtained. Based on the obtained S-N diagram, the fatigue test conditions for the Air-Servo Microfocus X-Ray CT System were determined, and X-ray CT imaging was performed. The process of crack propagation according to the number of cycles was observed in cross-sectional images and 3D images. In addition, by visualizing the displacement from a specific cycle onward, it was also confirmed that the specimen necked down just before fracture.&nbsp;</p><p>Using the measurement system introduced in this article, it is possible to observe changes in specimen shape over time while the specimen remains mounted in the jig. Therefore, not only the crack propagation process of a specimen during fatigue testing, but also material deformation behavior and the process of shape change can be observed.</p><h3><strong>4. Thermo Fisher Scientific: IonicX Portable XRF Analyzer Device and Algorithm</strong></h3><p><strong>A detailed look into the algorithm used to authenticate ionic salts</strong></p><ul><li>Other document</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/labrulez-bucket-strapi-h3hsga3/ionicx_portable_xrf_analyzer_device_and_algorithm_an1649_en_6ffee8a584.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/products/2026"><strong>Thermo Scientific™ IonicX™ Portable XRF Analyzer</strong></a> utilizes Energy Dispersive X-ray Fluorescence (ED XRF) spectrometry to confidently differentiate between different chemical samples based on their atomic structure and the average atomic weight of the sample. The basic elements of XRF spectrometer systems include a radiation source, a sample, and an X-ray detector. The analysis relies on the interaction of radiation source output (an X-ray source) with a sample, in this case, the cup of ionic salt material, such as Sodium Chloride, Potassium Chloride, Sodium Hydroxide or other chemicals and salts. The XRF system can characterize materials, due to the fundamental principle that each element has a unique atomic structure, which in turn has a unique set of peaks (x-ray lines) in its emission spectrum. The energy dispersive X-ray detector separates (disperses) the detected radiation emitted from the sample by energy, thus providing a spectrum from which the different elements present in the sample can be identified and/ or quantified.</p><h4><strong>Algorithm&nbsp;</strong></h4><p>Handheld XRF devices often cannot detect elements lighter than Magnesium by their fluorescence lines, however many compounds contain elements of interest such as Oxygen and Hydrogen. Additionally, relying solely on primary fluorescence peaks to identify target compounds can lead to misinterpretation. For instance, if MgO and NaCl are present in a 1:1 mixture, the resulting XRF spectrum would display distinct characteristic Mg and Cl peaks. However, the sample would not actually be the spectrum of MgCl₂, as the analytical response of Mg and Cl would be very different in both samples because of a dilution effect and absorption from Na and O atoms. The XRF process can easily differentiate samples with similar elemental constituents but with different chemical structures by analyzing the resulting scatter from the sample and comparing the full spectrum to a calibration library of compounds. Figure 4 shows XRF spectra of Sodium Chlorate (NaClO₃) and Sodium Perchlorate (NaClO₄) taken with the IonicX XRF instrument. In this example, only the Cl fluorescence peak can be detected by the IonicX device as Na and O fluorescence X-rays have energies that are too weak to be detected. However, when the spectrum is normalized, in this case to the primary Compton peak of Ag Kα, a slight but distinguishable difference can be seen in the spectral intensity between the energies of 25 keV and 40 keV. The difference in the scatter of the X-ray tube Bremsstrahlung is caused by differences in mass absorption coefficients of the presented samples, in this case it is the extra O atom in the NaClO₄ molecule vs the NaClO₃ molecule.</p><h4><strong>Summary&nbsp;</strong></h4><p>The IonicX Portable XRF Analyzer is a powerful addition for the verification of ionic salt type chemicals, utilizing XRF technology in a versatile, easy to use, small form factor. IonicX provides clear, easy to understand, unambiguous results and tools to assist with compliance and data integrity. IonicX is a robust verification tool which allows pharmaceutical companies to more efficiently verify incoming chemicals that typically have been tested using lengthy wet-chemistry techniques.</p>

News from LabRulezICPMS Library - Week 34, 2026

Separation Sciences in the Czech Republic: From Historical Foundations to Recent Advances

<p><strong>This study presents a robust GC-MS method for direct detection and quantification of hydrogen in complex gas mixtures using electron ionization without dopants, reagent gases, or ion–molecule reactions. A modified EI source combined with a cryogenically cooled single capillary column achieved baseline separation of hydrogen from permanent gases and hydrocarbons in refinery gas while using helium as the carrier gas.</strong></p><p>The method demonstrated high sensitivity, linearity, and reproducibility across trace- and percent-level hydrogen concentrations. By simultaneously profiling other gas components in a single run, the approach simplifies conventional multi-column workflows and extends GC-MS capabilities for hydrogen analysis in complex industrial gas mixtures.</p><blockquote><h4><strong>The original article</strong></h4><h4><a target="_blank" rel="noopener noreferrer" href="https://pubs.acs.org/ancham/article/98/26/19493/5200102/Hydrogen-Analysis-by-Gas-Chromatography-Mass#247324328"><strong>Hydrogen Analysis by Gas Chromatography–Mass Spectrometry&nbsp;</strong></a></h4><p>Vladislav V. Lobodin* ; Yensil Park; Charles E. A. Finney</p><p>Anal. Chem. (2026) 98 (26): 19493–19499.</p><div><a target="_blank" rel="noopener noreferrer" href="https://doi.org/10.1021/acs.analchem.6c00257">https://doi.org/10.1021/acs.analchem.6c00257</a></div><h6>licensed under <a target="_blank" rel="noopener noreferrer" href="https://creativecommons.org/licenses/by/4.0/"><strong>CC-BY 4.0</strong></a></h6></blockquote><p><strong>Selected sections from the article follow. Formats and hyperlinks were adapted from the original.</strong></p><div><div><div><div><p>Hydrogen analysis in complex gas mixtures, including permanent gases, and volatile and semivolatile organic and inorganic compounds, is crucial for optimizing hydrogen production, storage and use, and ensuring reliability across diverse applications. Accurate hydrogen analysis underpins production and distribution processes such as steam methane reforming, gasification, and electrolysis, helping maintain purity and quality throughout the supply chain. (<a href="javascript:;">1</a>) Reliable hydrogen measurements are also critical for fuel cell power generation, where automotive manufacturers and fueling stations must meet strict fuel quality standards to ensure safety and performance. (<a href="javascript:;">2, 3</a>) Hydrogen is a flammable, colorless, and odorless gas that poses significant hazards in air at levels between 4 and 74%. (<a href="javascript:;">4, 5</a>)</p></div><div><p>Many industrial processes, including chemicals and petrochemicals, steel manufacturing, glass production, and electronics, depend on precise hydrogen measurements for process control, quality assurance, and energy efficiency. (<a href="javascript:;">6−9</a>) Beyond these established uses, hydrogen analysis plays a vital role in energy storage, power generation, and utilization as a fuel for transportation and grid applications (e.g., power-to-gas and sustainable integration), with monitoring required to maintain the integrity and safety of stored and injected hydrogen. (<a href="javascript:;">10, 11</a>) It is also essential for environmental monitoring, including leak detection, emissions control, (<a href="javascript:;">5, 12</a>) and geological exploration of natural hydrogen sources. (<a href="javascript:;">13−15</a>) In the aerospace industry, hydrogen analysis ensures its safe handling and optimal performance of hydrogen as a fuel or propellant. (<a href="javascript:;">16−18</a>) In addition, forensic studies also rely on hydrogen measurements to provide critical evidence in criminal investigations and legal cases. (<a href="javascript:;">19, 20</a>)</p></div><div><p>A GC coupled to thermal conductivity detector (TCD) continues to be a common method of choice for hydrogen analysis despite the detector limitations. (<a href="javascript:;">21, 22</a>) However, the use of helium as a carrier gas, despite being the most popular choice, results in complications with a TCD because the thermal conductivity for hydrogen and helium is very close and hydrogen produces a relatively low and nonlinear response. To avoid the hydrogen–helium interference, argon or nitrogen is used as the carrier gas with a TCD. However, the use of those gases compromises chromatographic resolution, significantly reduces sensitivity for the other compounds by a factor of ∼10, and can interfere with the detection of other analytes.</p></div><div><p>Besides a TCD, a helium ionization detector (HID) and an atomic emission detector (AED) are utilized by coupling to a GC to analyze hydrogen. (<a href="javascript:;">23, 24</a>) As in the case of a TCD, these detectors suffer from limitations and more importantly are not informative enough for identification of unknown chromatographic peaks during the hydrogen production development. Raman spectroscopy can detect low hydrogen concentrations but suffers from low sensitivity, complex setups, and long measurement times. Commercial systems have high detection limits and reduced precision over time, limiting practicality for dynamic or in-line applications. (<a href="javascript:;">25, 26</a>)</p></div><div><p>In contrast, GC coupled to MS serves as a powerful tool for both qualitative and quantitative analysis of various compound mixtures. (<a href="javascript:;">27</a>) Nonetheless, it has been reported that GC–MS faces challenges due to the difficulties of detecting lighter gases relative to the carrier gas (<a href="javascript:;">28, 29</a>) and direct EI in the absence of a dopant and ion–molecule reactions has been considered an impossible task. (<a href="javascript:;">29</a>)</p></div><div><p>Chromatographic analysis of hydrogen typically involved a dual-column setup to effectively separate it from other gases like O<sub>2</sub>, N<sub>2</sub>, CO, CO<sub>2</sub>, CH<sub>4</sub>, and various volatile hydrocarbons. These setups often used packed columns or molecular sieves PLOT columns, which additionally necessitated a particle trap on the detector side to block sorbent particles from entering the mass spectrometer’s ion source. (<a href="javascript:;">30, 31</a>)</p></div><div><p>In the present study, we report the development of a novel method for hydrogen analysis that employs direct EI of hydrogen and a simplified column configuration with a single capillary column. This approach is capable of detecting hydrogen across a broad concentration range, including trace levels in complex matrices. Importantly, our method also delivers compositional information for other gases in a single run, which can provide valuable context for many applications, thereby providing a significant advancement in hydrogen analysis methodology.</p><h4><strong>Experimental Part</strong></h4><p>The development of the method for hydrogen analysis was conducted with a GC–MS instrument employing an <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=7890B"><strong>Agilent 7890B GC</strong></a> system and an <strong>Agilent </strong><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library?mainauthorItems=10&amp;search=5977B"><strong>5977B mass spectrometer</strong></a> (Agilent Technologies, Santa Clara, CA). The GC system was modified with a <strong>liquid N<sub>2</sub> cryogenic valve kit (Agilent G3466A) </strong>to enable operation at low temperatures and liquid N<sub>2</sub> (supplied from a Dewar) was used to cool the GC oven. Chromatography-grade helium with a purity of 99.9999% from Airgas (Radnor, PA) additionally passed through a helium purifier trap (model RMSH-2) from Agilent Technologies at a flow rate of 2.0 mL·min<sup>–1</sup> was used as a carrier gas. The gas chromatograph inlet temperature was set to 200 <span>°</span>C. The GC oven temperature was programmed to hold at −80 <span>°</span>C for 2 min, subsequently ramped to 260 <span>°</span>C at 20 <span>°</span>C·min<sup>–1</sup>, and then held for 17 min. The transfer line was kept at 260 <span>°</span>C. A GS-GASPRO GC column (60 m long, 320 μm ID) from Agilent Technologies was used for chromatographic separation. The ion source was held at 230 <span>°</span>C. The EI ion source was modified by replacing a standard (350 G) magnet with a low-gauss magnet (220 G) assembly (Agilent part: G3163-60560). The hydrogen tune macros were procured from Diablo Analytical (Antioch, CA) and are described elsewhere. (<a href="javascript:;">32</a>) Both selected ion monitoring (SIM) and scan modes (recorded as a total ion chromatogram [TIC]) were utilized for detection of hydrogen and other gases. In particular, hydrogen detection was performed using SIM mode at a mass-to-charge ratio (<i>m</i>/<i>z</i>) of 2.</p><h4><strong>Results and Discussion</strong></h4><div><p>Here, we describe the development of a new hydrogen analysis approach that utilizes direct EI and selective detection at <i>m</i>/<i>z</i> = 2. Because the conventional EI source magnetic field is optimized to confine and focus electrons for ionization of species with <i>m</i>/<i>z</i> ≥ 10, this configuration is suboptimal for hydrogen, resulting in limited ionization efficiency and inefficient extraction of low-mass ions. The modification of the EI ion source with a low-gauss magnet is necessary to improve the formation and detection of H<sub>2</sub><sup>+</sup> ions. Reduction of the magnetic field strength decreases confinement of ionizing electrons emitted by the filament, thereby increasing the effective interaction volume and residence time of electrons with hydrogen molecules and enhancing ionization probability. In addition, the reduced magnetic field mitigates discrimination against low-mass ions during extraction and transmission into the mass analyzer. Collectively, these effects enhance sensitivity for H<sub>2</sub> detection under EI conditions, eliminating the need for chemical ionization or indirect detection strategies.</p></div><div><p>In addition to the specialized hardware, custom low-mass optimization tune macros are required to achieve reliable sensitivity. We used tune macros from a hydrogen detection kit developed for Agilent MSD instruments that had been converted into standalone RGA-type mass analyzers. (<a href="javascript:;">32</a>) The tuning and mass-calibration procedure began with a low-mass autotune (lomass.u), followed by a helium optimization tune that used the helium carrier gas flowing through the column into the ion source as the tuning mixture. The optimization tune adjusts key ion–optics parameters, including repeller voltage, ion focus, electron energy, emission current, and entrance lens offset to maximize the response at <i>m</i>/<i>z</i> = 4. Additionally, ions at <i>m</i>/<i>z</i> = 69, 131, and 219 from the instrument’s calibration compound (PFTBA) were used to calibrate the mass axis, adjust the electron multiplier voltage, and set appropriate peak widths.</p><div><p>The mass spectrometry detection method involved simultaneous acquisition in SIM mode at <i>m</i>/<i>z</i> = 2 for hydrogen detection, and scan mode (at 2.4 scans s<sup>–1</sup>) within the range of <i>m</i>/<i>z</i> = 10–160 for other gases. Attempts to scan from <i>m</i>/<i>z</i> = 1.6 to 160 and subsequently extract the ion chromatogram at <i>m</i>/<i>z</i> = 2 resulted in a significantly lower signal response for hydrogen detection. Detection of hydrogen in SIM mode at <i>m</i>/<i>z</i> = 2 significantly improves the signal-to-noise (S/N) ratio and detection limit. The dwell time (the time during which the quadrupole is set at <i>m</i>/<i>z</i> = 2) was adjusted to 100 ms to enhance sensitivity. The high-resolution quadrupole settings (with peak width of 0.5 <i>m</i>/<i>z</i>) further improved S/N ratio by a factor of 2.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Anal_Chem_2026_98_26_19493_19499_Figure_1_GC_MS_analysis_of_hydrogen_standard_gas_mixtures_9439c835f2.jpg" alt="Anal. Chem. (2026) 98 (26): 19493–19499: Figure 1. GC–MS analysis of hydrogen standard gas mixtures. Upper figures show scans from m/z = 10–160, and lower figures show detection at m/z = 2. Left: 5% (50000 ppm) H2. Right: 5000 ppm of H2. Nitrogen is a balance gas." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Anal_Chem_2026_98_26_19493_19499_Figure_1_GC_MS_analysis_of_hydrogen_standard_gas_mixtures_9439c835f2.jpg 245w," sizes="100vw" width="1600" height="1022"></p></div><div><p>Standalone mass spectrometers (without GC) are often employed as RGAs, including for hydrogen detection. However, the absence of chromatographic separation limits reliable hydrogen quantification and comprehensive characterization of other species in a mixture. Furthermore, quadrupole mass spectrometers, commonly used both as RGAs and in GC–MS configurations, are subject to the “zero-blast” effect. (<a href="javascript:;">35</a>) This occurs when low DC voltage and RF amplitudes at low <i>m</i>/<i>z</i> are insufficient to prevent heavier ions from reaching the detector, leading to false signals in the low <i>m</i>/<i>z</i> range up to <i>m</i>/<i>z</i> = 4, even in the absence of corresponding low molecular weight analytes such as H<sub>2</sub> or He. (<a href="javascript:;">36</a>) The “zero-blast” effect is particularly noticeable when measuring low levels of hydrogen amidst significantly higher concentrations of heavier gases, e.g., N<sub>2</sub>, O<sub>2</sub>, CO, Ar, CO<sub>2</sub>, H<sub>2</sub>O, hydrocarbons. This interference, which fluctuates constantly, makes the detection and resolution of hydrogen peaks at <i>m</i>/<i>z</i> = 2 highly challenging. <a href="javascript:;">Figure 1</a> shows the GC–MS analysis of two standard gas mixtures containing 50000 and 5000 ppm hydrogen with nitrogen as the balance gas. The injected sample volume was 250 μL, and the split ratio was 20:1. The upper plots display total ion chromatograms for the mass range <i>m</i>/<i>z</i> = 10–160, where the peak at 4.1 min corresponds to N<sub>2</sub>. The lower plots show extracted ion chromatograms at <i>m</i>/<i>z</i> = 2, where the peak at 3.4 min represents H<sub>2</sub>, while the peak at 4.1 min, matching the nitrogen elution time, is a false signal caused by the “zero-blast” effect. This interference is especially pronounced at lower hydrogen concentrations and would significantly affect quantitation in the absence of chromatographic resolution. By separating hydrogen into a distinct chromatographic peak with GC–MS, the “zero-blast” interference can be minimized. Therefore, efficient chromatographic separation of hydrogen from other gases is essential for reliable detection and quantification.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Anal_Chem_2026_98_26_19493_19499_Figure_4_GC_MS_analysis_of_refinery_gas_mixture_2977041c4b.jpg" alt="Anal. Chem. (2026) 98 (26): 19493–19499: Figure 4. GC–MS analysis of refinery gas mixture. Top. TIC for m/z = 10–160. Bottom. SIM at m/z = 2." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Anal_Chem_2026_98_26_19493_19499_Figure_4_GC_MS_analysis_of_refinery_gas_mixture_2977041c4b.jpg 226w," sizes="100vw" width="1600" height="1104"></p><p><a href="javascript:;">Figure 4</a> presents the gas chromatographic separation and mass spectrometric detection of a refinery gas test mixture using a combined scan (<i>m</i>/<i>z</i> = 10–160) and SIM (<i>m</i>/<i>z</i> = 2) acquisition mode. The total ion chromatogram (top panel) demonstrates excellent baseline separation of all major permanent gases and hydrocarbons, including O<sub>2</sub>, N<sub>2</sub>, CO, CH<sub>4</sub>, CO<sub>2</sub>, C<sub>2</sub>H<sub>4</sub>, C<sub>2</sub>H<sub>6</sub>, propane, propylene, <i>n</i>-butane, iso-butane, and various C<sub>5</sub> isomers. Notably, even isobaric species such as N<sub>2</sub>, CO, and C<sub>2</sub>H<sub>4</sub>, each with nominal mass of 28 Da, are fully resolved chromatographically, enabling accurate identification and quantitation despite their identical molecular weights.</p><p>The SIM trace at <i>m</i>/<i>z</i> = 2 (bottom panel) highlights the selective detection of hydrogen. One of the most critical regions for hydrogen separation is between 2 and 7 min, where H<sub>2</sub> elutes well before O<sub>2</sub>, N<sub>2</sub>, CO, and CH<sub>4</sub>. This complete chromatographic resolution effectively eliminates interference from the quadrupole “zero-blast” effect and suppresses false low-mass signals that typically arise from high concentrations of heavier gases, thereby ensuring reliable and interference-free quantitation of hydrogen. The combination of efficient separation and SIM-based detection provides a robust analytical platform for accurate measurement of hydrogen in complex gas mixtures.</p></div></div><h4><strong>Conclusions</strong></h4><p>We successfully developed and validated a robust GC–MS method capable of directly detecting and quantifying hydrogen using EI without the need for dopants, reagent gases, or ion–molecule reaction schemes traditionally required for low-mass. By integrating specialized low-mass tuning procedures, a modified EI source, and a cryogenically cooled single-capillary column, we achieved efficient baseline chromatographic separation of hydrogen from other permanent gases, hydrocarbons, and isobaric species in complex gas mixtures. This separation was essential to eliminate false low-mass signals originating from the quadrupole “zero-blast” effect, and provided accurate, interference-free hydrogen quantitation. The method demonstrated high sensitivity and selectivity across more than 3 orders of magnitude concentration ranges from 5 to 5000 ppm, with excellent linearity (<i>R</i><sup>2</sup> = 0.9999). The combination of adjustable sample-loop volumes and tunable split ratios allowed optimization of peak shape and signal-to-noise performance for both trace-level and percent-level hydrogen concentrations. Triplicate analyses showed exceptional reproducibility, with variability below 1%, confirming suitability of the sampling approach for reliable quantitative analysis. Importantly, this approach provides simultaneous compositional information for a wide range of gases in a single analytical run, enabling comprehensive characterization of complex mixtures. This capability is particularly valuable for hydrogen production, storage, fuel-quality monitoring, geologic hydrogen exploration, industrial process control, safety and forensic applications, and environmental assessments where hydrogen must be measured alongside a panel of other gases.</p></div></div></div></div>

Hydrogen Analysis by Gas Chromatography–Mass Spectrometry

A Liquid–Liquid Extraction Method for Measuring Ultrashort PFCAs and Longer-Chain PFAS in Water

Direct Characterization of Halogen-Based Microplastics via Single-Event ICP-Mass Spectrometry in Negative-Ion Mode

<p><strong>In the week of August 24, the following webinars await you in the field of gas / solid phase and especially Raman, FTIR, GC and GC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Thermo Fisher Scientific: From legacy to leading edge: unlock more uptime, throughput, and confidence with modern GC-MS technology</strong></h5><ul><li>Tu, 25.8.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6457">Registration</a></li></ul><p>Discover how upgrading legacy GC-MS systems to the Thermo Scientific ISQ 7610 GC-MS and TSQ 9610 GC-MS/MS can improve performance, simplify maintenance, and reduce operating costs.</p><h5><strong>2. Waters Corporation: Foundations of a Sustainable, High-Performing QA Program</strong></h5><ul><li>We, 26.8.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/webinar/6448">Registration</a></li></ul><p>Build a sustainable, high-performing QA program in your lab. Learn the four pillars of data quality: method validation, analyst competency, control charting, and certified reference materials.</p>

Webinars LabRulezGCMS Week 35/2026

<p><strong>In the week of August 24, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Separation Science: From Downtime to Data: How Long-Life LC Columns Transform High-Throughput Labs</strong></h5><ul><li>Tu, 25.8.2026 14:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6447">Registration</a></li></ul><p>Extend your LC-MS/MS column lifetime. Learn how Phenomenex Endrix columns reduce downtime and lower cost per injection when analyzing complex matrices.</p><h5><strong>2. SCIEX: Distinguishing Ile/Leu variant ligands in the immunopeptidome using hybrid ExCID fragmentation on SCIEX accurate mass instrument</strong></h5><ul><li>We, 26.8.2026 05:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6449">Registration</a></li></ul><p>Differentiating Ile and Leu variants in immunopeptides can be challenging. Discover how SCIEX ZenoTOF hybrid ExCID (EAD+CID) fragmentation and optimized chromatography help resolve these variants.</p><h5><strong>3. Phenomenex: Fundamentals First Bio Series: Understanding Magnetic Bead-Based Extraction Techniques</strong></h5><ul><li>We, 26.8.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6437">Registration</a></li></ul><p>Compare magnetic beads with traditional sample preparation and learn how to improve selectivity, scalability, and reproducibility when isolating peptides, oligonucleotides, and mRNA for LC-MS.</p><h5><strong>4. Thermo Fisher Scientific: Simplifying Transcriptomics for Clinical Research with Ion AmpliSeq™ Technology</strong></h5><ul><li>We, 26.8.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6451">Registration</a></li></ul><p>Discover how Ion AmpliSeq Transcriptome technology simplifies gene expression profiling with a fast two-day turnaround for clinical research workflows.</p><h5><strong>5. Waters Corporation: Foundations of a Sustainable, High-Performing QA Program</strong></h5><ul><li>We, 26.8.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6448">Registration</a></li></ul><p>Build a sustainable, high-performing QA program in your lab. Learn the four pillars of data quality: method validation, analyst competency, control charting, and certified reference materials.</p><h5><strong>6. Waters Corporation: Tiny Plastics, Big Questions: Advances in Microplastics &amp; Nanoplastics Analysis</strong></h5><ul><li>We, 26.8.2026 19:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6450">Registration</a></li></ul><p>Explore complementary DLS and AF4-MALS techniques for nanoplastic fractionation together with high-throughput screening approaches for microplastics in drinking water.</p><h5><strong>7. Thermo Fisher Scientific: Tips and Tricks II: Optimising LC Column Separation</strong></h5><ul><li>Th, 27.8.2026 09:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6453">Registration</a></li></ul><p>Learn how mobile phase composition, pH, buffer selection, and column selectivity influence chromatographic resolution, analyte recovery, and reproducibility.</p><h5><strong>8. Thermo Fisher Scientific: Tips to power up your LC with Chromeleon software</strong></h5><ul><li>Th, 27.8.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6452">Registration</a></li></ul><p>Discover how Thermo Scientific Chromeleon software can increase sample throughput, automate data processing, and maximize productivity with Vanquish UHPLC systems.</p><h5><strong>9. Separation Science: The TFA &amp; DFA Challenge Solved: Ultra-Sensitive Detection with End-to-End Automation</strong></h5><ul><li>Th, 27.8.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6424">Registration</a></li></ul><p>Master ultra-short-chain PFAS analysis with an automated SCIEX LC-MS/MS workflow designed for sensitive TFA and DFA quantification.</p><h5><strong>10. Technology Networks: Tech Spotlight: Mass Spectrometry 2026</strong></h5><ul><li>Th, 27.8.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6409">Registration</a></li></ul><p>Explore innovations in mass spectrometry for omics and learn how advances in ion mobility and data analysis are accelerating biomarker discovery.</p><h5><strong>11. Agilent Technologies: Absolute Specular Reflectance made Easy in UV-Vis-NIR</strong></h5><ul><li>Th, 27.8.2026 20:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinar/6439">Registration</a></li></ul><p>Learn how the Cary 7000 enables accurate specular reflectance and transmission measurements without swapping accessories, supporting fast and precise testing across different angles.</p>

Webinars LabRulezLCMS Week 35/2026

<p><strong>In the week from August 24, the following webinars await you in the field of atomic and molecular spectroscopy and spectrometry</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Waters Corporation: Foundations of a Sustainable, High-Performing QA Program</strong></h5><ul><li>We, 26.8.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6448">Registration</a></li></ul><p>Build a sustainable, high-performing QA program in your lab. Learn the four pillars of data quality: method validation, analyst competency, control charting, and certified reference materials.</p><h5><strong>2. Agilent Technologies: Absolute Specular Reflectance made Easy in UV-Vis-NIR</strong></h5><ul><li>Th, 27.8.2026 20:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/webinar/6439">Registration</a></li></ul><p>Learn how the Cary 7000 enables accurate specular reflectance and transmission measurements without swapping accessories, supporting fast and precise testing at different angles in UV-Vis-NIR.</p>

Webinars LabRulezICPMS Week 35/2026

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 24th August 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Shimadzu, Thermo Fisher Scientific </strong>and <strong>Waters Corporation </strong>and poster by<strong> MDCW / GC Image!</strong></p><h3><strong>1. MDCW / GC Image: Alignment and Filtering Tools for Enhanced Differencing of Two-Dimensional Chromatograms</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/P_21_Wu_3838638ea4.pdf"><strong>Full PDF for download</strong></a></li></ul><section><div><div><div><div><div><div><h5><strong>Challenges&nbsp;</strong></h5><p>Chromatogram-like visual differencing is intuitive, yet simple pixel-to-pixel subtraction often produces noisy artifacts, fails to correct retention-time shifts, and can obscure low-intensity but meaningful differences.&nbsp;</p><p>Previously, we developed comparative visualization methods [1] based on classic image-comparison techniques, including:&nbsp;</p><ul><li>Alignment with specialized color maps to visually highlight discrepancies between chromatograms&nbsp;</li><li>Interactive matching across two chromatograms [2], enabling both qualitative and quantitative side-by-side assessment at the individual-peak level&nbsp;</li></ul><p>We extend this work by presenting a more robust chromatogram differencing visualization method designed to overcome these limitations</p><h4><strong>Example 1: Alignment for Data Fusion (FID vs MS)&nbsp;</strong></h4><ul><li><strong>Data Set:</strong> GCxGC data of a diesel fuel sample&nbsp;</li><li><strong>Instruments:</strong> <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=10&amp;search=7890A"><strong>Agilent 7890A GC</strong></a>/InfoMass L10 thermal modulator/Hexin TOFMS<ul><li><strong>Detectors:</strong> FID (350 C, 200 Hz), MS (45-450 m/z, 50 Hz)&nbsp;</li><li><strong>Modulation:</strong> 6 seconds with programmable cold jet gas flow (15L/min to 6 L/min)</li></ul></li></ul><h4><strong>Example 2: Differencing (GC×GC-MS)&nbsp;</strong></h4><ul><li><strong>Data Set: </strong>GCxGC-TOFMS data set of different dark chocolates [3].</li><li><strong>Instruments: </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=23&amp;search=AccuTof"><strong>JEOL AccuTof GC mass spectrometer</strong></a> with an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=10&amp;search=7890"><strong>Agilent 7890 GC</strong></a></li></ul><h4><strong>Example 3: Differencing with BPC (LC×LC-MS)&nbsp;</strong></h4><ul><li><strong>Data Set:</strong> LCxLC-MS data of different types of beer [4].&nbsp;</li><li><strong>Instruments: </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=10&amp;search=1290+infinity+2D-LC"><strong>Agilent 1290 Infinity 2D-LC</strong></a> solution coupled with an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=10&amp;search=6530"><strong>Agilent 6530 Accurate-Mass Q-TOF LC/MS system</strong></a></li></ul><h3><strong>2. Shimadzu: Comprehensive and High-Sensitivity Analysis of Food Aroma by Simultaneous Scan/MRM Measurement Using Triple Quadrupole GC-MS/MS</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_01_01269_en_657ee319e0.pdf"><strong>Full PDF for download</strong></a></li></ul><h4><strong>User benefits</strong></h4><ul><li>Simultaneous scan/MRM measurement enables comprehensive search by scan measurement and high-sensitivity analysis of trace aroma compounds by MRM in a single measurement.&nbsp;</li><li>With LabSolutions Insight Explore GCMS, deconvolution analysis of scan data and target analysis of MRM data are possible in a single software program.&nbsp;</li><li>The Multi-Mode Injection Unit (MMI), which allows rapid heating, supports aroma analysis in the thermal desorption (TD) mode</li></ul><p>The “aroma” of food products and beverages is a key factor that largely determines product quality and consumer preferences, and thus is an extremely important element in product development and quality control. Since the gas chromatograph mass spectrometer (GC-MS) provides excellent performance in qualitative analysis of volatile compounds, it is used to measure various aroma components that make up an odor. However, due to the diversity of aroma compounds and their wide concentration range, which extends from the ppm to the ppt order, an analytical method that allows efficient measurement of these substances is demanded.&nbsp;</p><p>Non-targeted analysis by scan measurement is an effective tool for comprehensive profiling, but in many cases, it is difficult to identify the trace components that make a significant contribution to aroma due to the limits of instrument sensitivity and matrix interference. On the other hand, although widetarget analysis by the MRM (Multiple Reaction Monitoring) mode using GC-MS/MS offers high sensitivity and selectivity for several hundred target components, MRM lacks a search capability for unknown components.</p><p>Therefore, this Application News article reports a technique that satisfies both comprehensive non-targeted search and highsensitivity detection of trace components in a single analysis by combining the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=1&amp;search=8040+RX"><strong>GCMS-TQ 8040 RX</strong></a>, which supports simultaneous data acquisition in simultaneous multi-component analysis measurements by scan measurement and the MRM mode, and the Smart Aroma Database for use in aroma analysis. In addition, in this experiment, the thermal desorption (TD) mode of the Multi-Mode Injection Unit (MMI) was adopted for sample introduction. This enablesintroduction of componentstapped on the adsorbent without using a dedicated TD device, thereby achieving a simplified system configuration.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>This Application News article showed that it is possible to achieve both a comprehensive non-targeted analysis of food aroma and a high-sensitivity wide-target analysis of trace components in a single analysis, without carrying out complicated operations, by simultaneous scan/MRM measurement combining the GCMSTQ8040 RX and the Smart Aroma Database. This article also demonstrated that use of the Multi-Mode Injection Unit (MMI) enables measurements in the thermal desorption (TD) mode without using dedicated TD instrumentation, and also allows a flexible response in case of budgetary or installation space limitations. A comprehensive aroma evaluation based on this approach will facilitate the discovery of important aroma components that were easily overlooked in the past, and is expected to make important contributions to product development and quality control in the food and beverage industries.</p><h3><strong>3. Thermo Fisher Scientific: Implementing EPA OTM-50 for PFAS destruction monitoring by TD-GC-MS/MS</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_004773_gc_td_gc_ms_epa_otm_50_pfas_an04773_na_en_99fd5fc528.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Per- and polyfluoroalkyl substances are used across a broad range of industrial and consumer applications. As PFAS-containing materials are treated or destroyed, incomplete decomposition can generate volatile fluorinated compounds, including short-chain and ultra-volatile species. These volatile compounds are important because they may provide evidence of incomplete mineralization once emitted from stationary sources.</p><p>EPA OTM-50 was developed to provide a consistent approach for collecting and quantitatively analyzing target VFCs from emissions originating from known industrial products with incomplete thermal destruction. The EPA method uses passivated stainlesssteel canisters followed by GC-MS analysis and is applicable to gas samples collected from industrial source ducts, vents, stacks, and related emission points.&nbsp;</p><p>The method is performance-based, allowing laboratories flexibility in GC column selection, GC conditions, and MS conditions, provided that GC-MS remains the basis for separation and quantitation and the required performance criteria are met. This flexibility is important because OTM-50 analytes span a challenging volatility range and may occur in complex matrices containing CO2 , water vapor, acid gases, and other volatile organic compounds.&nbsp;</p><p>Gas chromatography-based approaches are well suited to volatile and neutral fluorinated compounds. Thermal desorption enables preconcentration of trace-level analytes from air samples, improving sensitivity and enabling detection at relevant levels for environmental studies.&nbsp;</p><p>This application note describes implementation of EPA OTM-50 using cryogen-free thermal desorption coupled to triple quadrupole GC-MS/MS. The workflow addresses key analytical challenges: trapping ultra-volatile compounds such as CF4 , managing high levels of CO2 and humidity, achieving sub-ppbv sensitivity, and maintaining repeatable quantitative performance in support of PFAS destruction monitoring.</p><h4><strong>Experimental&nbsp;</strong></h4><h5><strong>Instrument configuration&nbsp;</strong></h5><p>The analytical system consisted of a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=6&amp;search=UNITY-Kori-CIA"><strong>Markes UNITY</strong></a><strong>-Kori-CIA Advantage HL-xr thermal desorption system</strong> coupled to a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/485"><strong>TSQ 9610 Triple Quadrupole GC-MS/MS</strong></a> equipped with a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=3&amp;search=nevervent"><strong>Thermo Scientific™ NeverVent™ AEI Ion Source</strong></a> (Figure 1). The Markes thermal desorber configuration included cryogen-free focusing, controlled canister introduction, and water and CO2 management strategies.</p><h4><strong>Conclusions&nbsp;</strong></h4><p>This work demonstrates implementation of EPA OTM-50 using thermal desorption coupled to triple quadrupole GC-MS/MS for the analysis of volatile fluorinated compounds in air, with solutions helping to solve key analytical challenges for this type of analysis.&nbsp;</p><ul><li><strong>Alignment with EPA OTM-50 scope:</strong> supports canisterbased analysis of VFCs emitted from stationary sources, including compounds associated with incomplete PFAS destruction.&nbsp;</li><li><strong>Cryogen-free preconcentration:</strong> enables practical trapping and transfer of volatile analytes without reliance on liquid cryogens, reducing operational complexity.&nbsp;</li><li><strong>Improved selectivity through MS/MS: </strong>SRM acquisition on the TSQ 9610 Triple Quadrupole GC-MS/MS improves confidence in target identification and quantitation in complex emission matrices.&nbsp;</li><li><strong>Dual-method strategy for broad volatility coverage:</strong> separate sample volumes for CF4 and the remaining VFCs enable analysis across the challenging OTM-50 volatility range.&nbsp;</li><li><strong>CO2 and humidity management:</strong> controlled dilution, selective trap purging, and Kori-xr water management address two of the most significant matrix challenges in stationary source emissions.&nbsp;</li><li><strong>Robust quantitative performance: </strong>calibration across 0.1–100 ppbv (0.125–50 ppbv for CF4 ) showed R2 ≥ 0.998 for reported compounds or &lt; 20% RSD for Average Response Factor, with pptv MDLs and repeatability generally consistent with OTM-50 precision expectations.&nbsp;</li><li><strong>Industrial relevance: </strong>the workflow supports chemical manufacturing, PFAS treatment, and waste management facilities seeking defensible data to evaluate destruction efficiency and identify products of incomplete destruction.&nbsp;</li></ul><p>Overall, the combination of Markes thermal desorption technology with the Thermo Scientific TSQ 9610 Triple Quadrupole GC-MS/MS provides a practical, selective, and robust analytical approach for laboratories implementing EPA OTM-50 for volatile PFAS and VFC monitoring in air.</p><h3><strong>4. Waters Corporation: Analysis of Polybrominated Diphenyl Ether Flame Retardants in Environmental Matrices Using Atmospheric Pressure Chemical Ionization GC-MS/MS</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/720009524_en_58a948f96a.pdf"><strong>Full PDF for download</strong></a></li></ul><h4><strong>Benefits&nbsp;</strong></h4><ul><li>The performance of atmospheric pressure gas chromatography (APGC ™) on Xevo™ TQ Absolute Mass Spectrometer for the analysis of PBDEs is equal-to or better-than traditional analysis using electron impact magnetic sector making it well suited for use in the most challenging regulatory and standard methods.</li><li>The ability of APGC to tolerate high carrier gas flow helps improve method performance for the most challenging members of this class inlcuding BDE 209 which reduces the need for maintenance and reanalysis of samples.</li><li>Operator training is reduced to weeks from months through conversion of the method from a magnetic sector to tandem quadrupole mass spectrometer.</li><li>Use of a single, inexpensive, readily available gas for chromatographic separation, ionization and MS/MS fragmentation provides a simpler, more sustainable system.</li></ul><p>With the 2001 signing of the Stockholm Convention, the stage was set for global harmonization of efforts to monitor for POPs in the environment.1 By 2004, when countries began implementing the convention, measures aimed at reducing or eliminating intentional and unintentional release of POPs into the environment were supported by annexes that defined the different chemical classes of highest interest which included PBDEs. To date, 185 states plus the European Union have joined in this effort which includes requirements for monitoring for POPs in multiple environmental matrices. Because the implications of unintentional or intentional noncompliance may be subject to enforcement action, high confidence data is needed to support surveillance and reporting efforts. Furthermore, high sensitivity analysis is required due to the possibility of steadily increasing trace levels of PBDEs across years of time through transport in the environment that tends to increase concentrations of persistent organic pollutants such as these in cooler Arctic regions of the globe through the grasshopper effect.2 These requirements initially led to the development of gas chromatography electron ionization high resolution magnetic sector based analytical methods. The performance of EI GC-HRMS in the hands of a well-trained operator and a lab with rigorous quality control procedures has proven to provide the sensitivity and specificity required of the forensic data used in legal actions, for compliance reporting and for providing the greatest protection to populations and the environment.&nbsp;</p><p>However, GC-HRMS has several limitations, including extensive education and training requirements, slow acquisition speeds, and significant laboratory space demands. In contrast, more modern techniques such as tandem quadrupole (TQ) mass spectrometry (MS/MS) offer broad improvements in these areas. Additionally, limitations imposed by EI such as frequent source maintenance and shortcomings caused by carrier gases other than helium hamper this time-honored technique. The more recent combination of APCI with TQ has demonstrated promise in overcoming these limitations while providing data of equivalent confidence to EI GCHRMS.&nbsp;</p><p>After having been deployed in many labs, GC-APCI has continued to contribute to the study of PBDEs in multiple matrices and applications. An evaluation of the first generation of GC-APCI MS/MS, analyzing PBDEs in marine and food samples, reported higher response for higher brominated (Br8-10) congeners than GC-EI-HRMS.3 Later work reported GC-APCI MS/MS LODs comparable or better than EI MS/MS for plasma extracts.4 Recent work reported on the use of GC-APCI HRMS (QTof) as part of the continuation of a 20 year study analyzing aquatic organisms to evaluate environmental PBDE trends.5 In this work, 24 PBDEs plus hexabromobiphenyl were analyzed on a XevoTM TQ Absolute Tandem Quadrupole Mass Spectrometer using the APGC ionization source.</p><h4><strong>Experimental</strong></h4><ul><li><strong>GC system: </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=10&amp;search=8890"><strong>8890 (Agilent Technologies, Inc.)&nbsp;</strong></a></li><li><strong>Column: </strong>Rtx®-1614, 15 m x 0.25 mm ID x 0.10 µm film (Restek Corporation)</li><li><strong>MS system: </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/554"><strong>Xevo TQ Absolute Mass Spectrometer</strong></a></li><li><strong>Software: </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1544"><strong>waters_connect™</strong></a> for Quantitation Software</li></ul><h4><strong>Conclusions&nbsp;</strong></h4><p>An all-nitrogen configuration for APGC on Xevo TQ Absolute Mass Spectrometer was successfully applied to the analysis of PBDEs in environmental matrices by adapting a reference method previously used on magnetic sector EI GC-HRMS. All performance criteria were equal-to or better-than those typically achieved by magnetic sector which demonstrates feasibility of GC-APCI MS/MS as an alternative for the most challenging regulatory and standard analytical methods. Furthermore, the change from a vacuum source to the atmospheric ionization source makes the use of high nitrogen carrier gas flow practical which has advantages for operating cost versus helium while achieving similar chromatographic separation and sensitivity. The move to tandem quadrupole mass spectrometry from high resolution mass spectrometry updates the method for improved performance measures such as higher acquisition speeds and high specificity MS/MS while also requiring reduced training time and expertise as compared with magnetic sectors.</p></div></div></div></div></div></div></section>

News from LabRulezGCMS Library - Week 35, 2026

Article

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Events

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Application

Academy

Video

Poster

Scientists

Plastics

Environment

Food

Water

Health

Presentation

Scientific article

Interview

Toxicology

Popularization

Science and research

Software

Covid-19

Career

Laboratories

Various

PFAS 

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Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Thermo Fisher Scientific Mass Spectrometry Users’ Meetings 2026

Bruker at Dioxin 2026

The International School on Mass Spectrometry (IntSMS) 2026

Polymeric, porous, monodisperse particle development and application to reversed-phase separations of biological molecules

Navigating PFAS Restrictions in Packaging and Packaging Waste (PPRW) with Py-GC-MS

Using Targeted Methylation Sequencing to Bring Epigenetic Biomarkers to the Clinic