<p><strong>Post-translational modifications (PTMs) are where so much of biology’s complexity lives, but they are also some of the hardest molecular features to analyze with confidence. Phosphorylation, asymmetric dimethylarginine (ADMA), and O-GlcNAcylation (O-GlcNAc) often occur at low abundance, can be highly labile, and frequently require precise site localization to understand their biological meaning. This</strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/tn_004377_ov_phosphorylation_ptm_etd_excedion_pro_tn004377_na_en_71f681655f.pdf"><strong> technical note </strong></a><strong>shows how the </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1958"><strong>Thermo Scientific Orbitrap Excedion Pro Hybrid Mass Spectrometer</strong></a><strong> helps address those challenges by combining fast, sensitive performance with complementary </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/article/7217"><strong>HCD and EThcD fragmentation</strong></a><strong> workflows.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Phosphorylation_ADMA_and_O_Glc_N_Ac_Analysis_on_the_Orbitrap_Excedion_Pro_Mass_Spectrometer_d24a5de98e.jpg" alt="Thermo Fisher Scientific: Phosphorylation, ADMA, and O-GlcNAc Analysis on the Orbitrap Excedion Pro Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Phosphorylation_ADMA_and_O_Glc_N_Ac_Analysis_on_the_Orbitrap_Excedion_Pro_Mass_Spectrometer_d24a5de98e.jpg 245w," sizes="100vw" width="1024" height="512"></p><p>Using enriched PTM samples and automated data-dependent acquisition, the study demonstrates that the <strong>Orbitrap Excedion Pro MS</strong> can deliver both depth and confidence across multiple PTM classes. For phosphorylation analysis, the platform identified 5,892 unique phosphosites from IMAC-enriched samples and <strong>2,941 </strong>unique phosphotyrosine sites after phosphotyrosine enrichment, highlighting strong performance for both broad and highly targeted signaling studies. Just as importantly, the data show that HCD and EThcD provide complementary value, with each fragmentation method contributing unique site identifications and helping resolve ambiguous assignments.</p><p>The note also highlights the value of EThcD for more analytically demanding PTMs. In ADMA-enriched samples, EThcD delivered more ADMA peptide-spectrum matches and more unique modified peptides than HCD, supporting improved confidence in site characterization. For O-glycopeptides, the Orbitrap Excedion Pro MS uses an intelligent HCD-product-dependent-EThcD strategy that triggers EThcD only when oxonium ions are detected, improving productivity while preserving the fragmentation detail needed for confident glycosite localization.</p><p>Overall, this technical note shows how <strong>Orbitrap Excedion Pro MS </strong>enables researchers to go deeper into PTM biology with greater sensitivity, better site confidence, and smarter acquisition. For scientists studying signaling, regulation, and disease mechanisms, it presents a powerful approach for expanding PTM coverage without compromising analytical rigor.</p><blockquote><h5><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/tn_004377_ov_phosphorylation_ptm_etd_excedion_pro_tn004377_na_en_71f681655f.pdf"><span><strong>Download the technical note</strong></span></a></h5></blockquote><p><strong>Visit us on&nbsp;</strong><a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/"><strong><u>LinkedIn:</u></strong></a>&nbsp;#PTM #OrbitrapExcedionPro #glycosylation #phosphorylation</p>

Phosphorylation, ADMA, and O-GlcNAc Analysis on the Orbitrap Excedion Pro Mass Spectrometer

<p><strong>The countdown is almost over. In just one week, the international chromatography community will meet in Prague for the </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/events/644"><strong>35th International Symposium on Chromatography (ISC 2026)</strong></a><strong>, taking place from September 6–10, 2026. Whether your registration has been confirmed for months or you are still deciding whether to join, now is the time to finalize your plans. Here is what you need to know before ISC 2026 begins.</strong></p><p><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/companies/314"><strong>ISC</strong></a> is the oldest conference series dedicated to separation science, with symposia organized since 1956. This September, the Prague Congress Centre will welcome researchers, industry experts, instrument manufacturers, young scientists, and other specialists for five days of chromatography and separation science, covering everything from fundamental research to pharmaceutical, environmental, food, health, and omics applications.</p><p>But before the scientific sessions begin, there are a few practical details worth checking.</p><h4><strong>ISC officially starts on September 6 – but activities begin a day earlier</strong></h4><p>The official dates for ISC 2026 are <strong>Sunday, September 6 through Thursday, September 10</strong>, but for some participants the conference starts already on <strong>Saturday, September 5</strong>.</p><p>The first <strong>Short Courses </strong>are scheduled for Saturday (<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/6770"><strong>SC 1 – Modern HPLC Separation in Theory and Practice</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7312"><strong>SC 2 – mzmine for LC-MS data analysis</strong></a>), with additional courses continuing on Sunday morning and afternoon. If you have registered for a Short Course, make sure to check its exact date and starting time before arranging your journey to Prague.</p><p>Sunday then marks the official opening of ISC 2026, with the <strong>Opening Ceremony, Award Ceremony, </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7361"><strong>plenary lectures</strong></a><strong>, and Welcome Reception</strong> introducing delegates to the week ahead.</p><h4><strong>Haven’t registered yet? You can still join ISC 2026</strong></h4><p>Missed the late-registration deadline? It is <strong>still possible to attend</strong>.</p><p>Onsite registration has been available since <strong>August 26, 2026</strong>, giving last-minute participants another opportunity to join the symposium. Current onsite registration fees are:</p><ul><li><strong>Industry:</strong> €1,150</li><li><strong>Academic:</strong> €890</li><li><strong>Student:</strong> €390</li><li><strong>Short Courses:</strong> €270</li></ul><p>The Short Course fee covers participation in up to three Short Courses.</p><p>One practical point for last-minute registration: bank-transfer payments closed on August 19, so <strong>only card payments are now accepted</strong>.</p><p>Full registration includes access to oral and poster sessions, the exhibition, the Sunday Welcome Reception, scheduled lunches and coffee breaks, the electronic Book of Abstracts, and a <strong>Prague public transportation pass</strong>.</p><h4><strong>Where is ISC 2026 and how do you get there?</strong></h4><p>ISC 2026 will take place at the:</p><p><strong>Prague Congress Centre</strong></p><ul><li>5. května 65</li><li>140 21 Prague 4</li><li>Czech Republic</li></ul><p>The venue is particularly easy to reach by public transport. It is located directly on Prague’s <strong>Metro Line C at Vyšehrad station</strong>, just around five minutes by metro from Muzeum station in the city centre.</p><p>The Prague Congress Centre brings the lecture halls, exhibition spaces, meeting rooms, and other conference facilities together in one venue, making it easy to move between scientific sessions, posters, industry activities, and the exhibition throughout the day.</p><p>And since full conference registration includes public transportation in Prague, getting around the city during ISC should be straightforward.</p><h4><strong>When can you pick up your conference materials?</strong></h4><p>The registration desk will already be open during the Short Courses and will remain available throughout the symposium.</p><p><strong>Registration opening hours:</strong></p><ul><li><strong>Saturday, September 5:</strong> 8:30–17:00</li><li><strong>Sunday, September 6:</strong> 7:30–19:00</li><li><strong>Monday, September 7:</strong> 7:30–18:00</li><li><strong>Tuesday, September 8:</strong> 7:30–19:00</li><li><strong>Wednesday, September 9:</strong> 8:00–18:00</li><li><strong>Thursday, September 10:</strong> 8:30–14:30</li></ul><p>If you are arriving in Prague on Sunday, allowing some extra time for registration before the Opening Ceremony will make the start of the conference considerably more relaxed.</p><h4><strong>Now is the time to build your personal ISC program</strong></h4><p>With several parallel sessions running throughout the week, trying to decide where to go only after arriving at the venue may mean missing something important.</p><p>The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7477"><strong>main scientific program</strong></a> is organized around three broad areas:</p><ul><li><strong>Fundamentals</strong></li><li><strong>Bioanalysis and omics applications</strong></li><li><strong>Hyphenated techniques</strong></li></ul><p>These are complemented by <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7280"><strong>Tutorials </strong></a><strong>+ Young Speakers</strong>, plenary and invited lectures, poster sessions, the international exhibition, vendor seminars, and industry-focused activities.</p><p>Before leaving for Prague, take another look at the <strong>Interactive Program</strong> and mark the lectures, posters, and other activities that are most relevant to you. If you are presenting your own work, this is also the right time to double-check your assigned session, room, and presentation time.</p><p>And don’t focus only on the oral program. <strong>Poster sessions and exhibition breaks</strong> are among the best opportunities to discuss new research directly with authors, meet instrument and technology specialists, and make new contacts.</p><h4><strong>Don’t overlook the vendor seminars and industry program</strong></h4><p>ISC 2026 is not limited to academic presentations. The conference also includes an extensive industry component, with activities covering current challenges in separation science and practical applications of new analytical technologies.</p><p>During the lunchtime sessions, participants can attend <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7736"><strong>vendor seminars</strong></a> presented by companies including <strong>Avantor, Shimadzu, Advanced Materials Technology, Restek, and Thermo Fisher Scientific</strong>. Topics range from stationary-phase selectivity and chromatographic modelling to HPLC and LC-MS column technologies and advanced characterization of biotherapeutics.</p><p>The conference also includes dedicated <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7777"><strong>Industry Activities</strong></a> <strong>from Monday through Wednesday</strong>, bringing together academic and industrial perspectives on topics relevant to analytical laboratories and the future of separation science. One of the discussions, for example, will examine how education in separation science can better reflect the skills required by modern industry, while another will focus on sustainability and the practical implementation of greener analytical workflows.</p><p>On Wednesday, participants can also join the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7801"><strong>Publishing Workshop</strong></a>, another activity worth adding to the schedule if scientific publishing is part of your work.</p><h4><strong>Test your chromatography knowledge at the ISC Quiz</strong></h4><p>Not every session needs to be completely serious.</p><p>On <strong>Tuesday, September 8 from 18:30 to 19:30</strong>, ISC will host an interactive <strong>Chromatography Quiz</strong>, combining practical questions, chromatography fundamentals, unusual facts, and lighter challenges.</p><p>There is <strong>no advance registration required</strong>. Any registered conference participant can join, but remember to bring a smartphone—the quiz uses live participation through a QR code.</p><p>Results will be scored in real time, and prizes will be awarded to the <strong>top three participants</strong>.</p><h4><strong>Start networking from the first evening</strong></h4><p>The scientific program may be the main reason to attend ISC, but the conversations between sessions can be equally valuable.</p><p>The first major networking opportunity comes immediately on Sunday.</p><p>The <strong>Welcome Reception</strong> will take place on <strong>September 6 from 18:30 to 20:00</strong> in the second-floor foyer of the Prague Congress Centre. It is open to registered participants and accompanying persons and includes a light buffet and drinks.</p><p>As it takes place immediately after the opening program, it is an ideal opportunity to reconnect with colleagues, meet new contacts, and start conversations before the full parallel scientific program begins on Monday.</p><p>Another social highlight will be the <strong>Gala Dinner on Wednesday, September 9 from 19:00 to midnight</strong> at the National House Vinohrady.</p><p>The Gala Dinner requires a separate <strong>€100 ticket</strong>, is not included in the standard registration fee, and has a smart-casual dress code. Participants should also note that transportation to and from the venue is not organized by the conference.</p><h4><strong>And perhaps leave a little time for Prague</strong></h4><p>A conference schedule can fill up quickly, but ISC 2026 is taking place in one of Europe’s most walkable cities.</p><p>If you find some free time between sessions, <strong>Vyšehrad is only about a 10-minute walk from the Prague Congress Centre</strong> and offers panoramic views across Prague and the Vltava River. It is an easy option for a short walk without travelling back into the historic city centre.</p><p><strong>See you at ISC 2026 in Prague!</strong></p>

ISC 2026 Starts in One Week: What You Need to Know

<p><strong>In the week of August 31, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Technology Networks: Modern Methods for Faster Microbial Analysis</strong></h5><ul><li>Tu, 1.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6454">Registration</a></li></ul><p>Struggling to choose the right technique for microbial testing? Learn how MALDI-TOF, FTIR, and automated DNA/RNA electrophoresis accelerate identification.</p><h5><strong>2. Phenomenex: Addressing LC Method Optimization - Scaling For Efficiency, Throughput And Reproducibility</strong></h5><ul><li>We, 2.9.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6458">Registration</a></li></ul><p>Join this webinar on LC method optimization and scaling. Learn how column dimensions, particle morphology, and sample loading strategies maximize throughput and reproducibility.</p><h5><strong>3. Thermo Fisher Scientific: Proteoform Studio software, top down made simple</strong></h5><ul><li>We, 2.9.2026 14:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6459">Registration</a></li></ul><p>Learn how Thermo Scientific Proteoform Studio software simplifies top-down MS and intact protein analysis through integrated workflows, interactive deconvolution, and reporting.</p><h5><strong>4. Agilent Technologies: Targeted Hybridization Capture for Antimicrobial Resistance Surveillance in Complex Environmental Samples</strong></h5><ul><li>We, 2.9.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6455">Registration</a></li></ul><p>Discover how Agilent SureSelect hybrid capture enhances antimicrobial resistance gene detection and characterization in complex environmental samples compared with shotgun NGS.</p><h5><strong>5. Thermo Fisher Scientific: Ask the Expert: What to expect from the new Thermo Scientific™ Orbitrap™ Excedion™ Hybrid mass spectrometers</strong></h5><ul><li>Th, 3.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6466">Registration</a></li></ul><p>Discover the new Orbitrap Excedion Hybrid Mass Spectrometer and learn how enhanced dynamic range, robust performance, and an upgradeable design support advanced HRAM workflows.</p><h5><strong>6. Waters Corporation: Informatics series #34 Ready for Self-Documenting Chromatography?</strong></h5><ul><li>Th, 3.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6426">Registration</a></li></ul><p>Speed up root cause analysis with self-documenting LC and Empower software in this 30-minute Waters coffee break.</p><h5><strong>7. SciY/Mestrelab Research: From Legacy Workflows to Paperless Labs: Track Every Sample, Process, and Decision</strong></h5><ul><li>Th, 3.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6425">Registration</a></li></ul><p>Transform your lab from paper to digital. Learn how WebLab and LIMS workflows automate sample tracking and support laboratory compliance.</p><h5><strong>8. SelectScience: ADC characterization in one native LC-MS workflow</strong></h5><ul><li>Fr, 4.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6460">Registration</a></li></ul><p>Simplify ADC characterization with native RP-LC-MS using Biozen® columns to determine DAR, proteoforms, and positional isomers without buffer exchange.</p>

Webinars LabRulezLCMS Week 36/2026

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The International Symposium on Chromatography (ISC) represents the oldest conference series focussing on separation science. ISC symposia have been organised since 1956 in each even year. ISC is internationally recognised as one of the premier meeting series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.

International Symposium on Chromatography - (ISC)

Waters ACQUITY QDa II Mass Detector

The ACQUITY™ QDa™ II Mass Detector enhances efficiency and productivity in separations workflows with advanced technology.

<h3><strong>Advancing the Power of Mass Detection</strong></h3><ul><li><strong>Identify Everything in Your Sample with Complete Confidence&nbsp;</strong></li></ul><h5><strong>Information-rich mass spectral data starts here&nbsp;</strong></h5><p><strong>Built on a solid foundation of groundbreaking technology, the ACQUITY™ QDa™ II Mass Detector provides even more efficiency and productivity of separations workflows, providing information-rich mass spectral data, ensuring compliance, and regulatory certainty.</strong></p><h4><strong>SEE MORE COMPOUNDS</strong></h4><p>Greater compound coverage from an extended mass range to support small molecules, large molecules and new modalities. A complementary technique to analog detection for chemicals with no chromophores, ACQUITY QDa II Mass Detector enables you to confirm the identity and purity of more compounds with the power of mass detection.</p><h4><strong>ANALYZE MORE SAMPLES</strong></h4><p>Robust, reliable and requiring no sample-specific adjustment. Simply power on to make informed decisions with the full picture of what’s in your sample. Minimal maintenance along with system performance monitoring ensures maximum uptime.&nbsp;</p><h4><strong>HAVE MORE CONFIDENCE IN THE ROBUSTNESS OF YOUR SEPARATIONS</strong></h4><p>The addition of mass detection to your method development workflow enables fast peak tracking and greater confidence in peak purity, for more robust separations. Combined with industry-leading AQbD method development software, your lab can achieve unprecedented MS peak tracking functionality with the ACQUITY QDa II Mass Detector.</p><h4><strong>STRIVE FOR MORE SUSTAINABILITY</strong></h4><p>Achieve up to a 70% reduction in energy consumption and heat output compared to other vendor’s MS systems. The ACT Environmental Impact Factor Label<strong>*</strong> -- available and published by My Green Lab – provides clear, third-party verified information about the environmental impact of laboratory products, enabling you to make the most sustainable decisions for your organization.</p><p><strong>* </strong>ACT - About (<a target="_blank" rel="noopener noreferrer" href="https://www.mygreenlab.org/">mygreenlab.org</a>)</p><h3><strong>Continuing to Separate Beyond Question</strong></h3><ul><li><strong>Ensure your laboratory is prepared for the future</strong></li></ul><h4><strong>MORE PERFORMANCE</strong></h4><p>Plug and play performance with its intuitive design, complementary to optical detection with the robustness to handle all of your analyses. Working in harmony with your chromatography, it’s pre-optimized to work with your samples, without the sample-specific or user adjustments typical of traditional mass spectrometers.</p><h4><strong>MORE EFFICIENCY</strong></h4><p>The intuitive design of the ACQUITY QDa II Mass Detector provides additional data without cost or complexity. The most information you can get out of your separation for complete characterization. In synergy with optical detection, you can significantly reduce the chance that a sample component will go undetected helping to mitigate risk and ensuring a sound return on your investment.</p><h4><strong>MORE SUSTAINABILITY</strong></h4><p>Purposeful innovation, a stackable mass detector that seamlessly integrates into existing workflows resulting in less bench space and more energy efficient. Minimal cleaning and routine maintenance ensuring maximum uptime. Compatible with green solvents ensuring reduced environmental impact.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Q_Da_II_Mass_Detector_3_f98f84c080.jpg" alt="Waters ACQUITY QDa II Mass Detector." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Q_Da_II_Mass_Detector_3_f98f84c080.jpg 234w," sizes="100vw" width="1024" height="682"></p><ul><li>Simply power on, and you’re ready to go</li><li>Zero user set-up optimization, calibration, or adjustment</li><li>Run your analyses − it just works</li><li>When you’re done, just power-off</li></ul><h3><strong>The Perfect Partner</strong></h3><h4><strong>Designed for compatibility with your chromatography&nbsp;</strong></h4><p>Meet all your chromatography requirements with Waters chromatography systems, including our dependability and flexibility ranges of HPLC systems, performance range of UPLC systems, and our purification and specialty systems.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Q_Da_II_Mass_Detector_The_Perfect_Partner_Designed_for_compatibility_with_your_chromatography_1042adecb0.jpg" alt="Waters ACQUITY QDa II Mass Detector: The Perfect Partner. Designed for compatibility with your chromatography." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Q_Da_II_Mass_Detector_The_Perfect_Partner_Designed_for_compatibility_with_your_chromatography_1042adecb0.jpg 189w," sizes="100vw" width="1299" height="1074"></p><h3><strong>Effortless Integration</strong></h3><h4><strong>Achieve more with flexible software solutions</strong></h4><p>Process, Interpret, visualize, and compare the most complex data, and turn it into meaningful information quickly and simply. With integrated optical and mass detector data processing workflows, you can also analyze mass spectral data in the same way as you do photo diode array (PDA) data.</p><p>The ACQUITY QDa II Mass Detector is fully compatible with Masslynx™ Software and its suite of data processing application managers. Empower™ Software, our industry-leading chromatography data software platform is also fully compatible providing the ultimate flexibility.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Q_Da_II_Mass_Detector_Effortless_Integration_Achieve_more_with_flexible_software_solutions_4fd6e9f0d8.jpg" alt="Waters ACQUITY QDa II Mass Detector: Effortless Integration. Achieve more with flexible software solutions." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Q_Da_II_Mass_Detector_Effortless_Integration_Achieve_more_with_flexible_software_solutions_4fd6e9f0d8.jpg 245w," sizes="100vw" width="1397" height="422"></p><h4><strong>EMPOWER CHROMATOGRAPHY DATA SYSTEM (CDS)</strong></h4><p>Simplifying the way you collect, manage, and report chromatography test results is critical to your lab efficiency. With a suite of flexible functionalities that grows to meet your changing quality, business, and laboratory needs, Empower CDS has been purposefully designed to help you address your most demanding chromatographic, regulatory, and networking challenges.</p><h4><strong>EMPOWER LAB MANAGEMENT SYSTEM (LMS)</strong></h4><p>Automating your lab workflow, from sample creation to data archival, is critical for maintaining data integrity and enhancing productivity. Manage your data all from a single, simple dashboard for an integrated approach to your product lifecycle management so you can reduce transcription errors, increase efficiency, and maximize data durability.</p><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1544"><strong>waters_connect™</strong></a><strong> SYSTEM MONITORING</strong></h4><p>Monitor all Empower Software-controlled chromatography systems remotely, at any time, from anywhere. Dynamically plan laboratory activities, monitor the status of your laboratory and maximize productivity. Troubleshoot and respond to errors faster, increasing system uptime.</p><h3><strong>Identify More in Released Glycan Analysis</strong></h3><h4><strong>Unlock the full potential of your QC glycan testing</strong></h4><p>While non-MS methods offer routine QC capabilities, they fall short in delivering the detailed characterization, crucial for biopharmaceutical development. The ACQUITY QDa II Mass Detector with extended mass range revolutionizes routine analysis, offering accurate QC monitoring of N-glycan species with speed and precision. Coupled with Waters chromatography systems, enjoy enhanced MS response with uniform charge state for accurate quantitation, enabling scrutiny of released N-glycan profiles in under 40 minutes per sample. Complement fluorescence (FLR) detection and embrace reproducible, quantitative separation for rapid decision-making.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Q_Da_II_Mass_Detector_Selected_Ion_Recording_SIR_chromatogram_of_doubly_charged_components_of_a_glycan_sample_Highlighted_additional_components_identified_s_a_result_of_the_extended_mass_range_ac0160e74d.jpg" alt="Waters ACQUITY QDa II Mass Detector: Selected Ion Recording (SIR) chromatogram of doubly charged components of a glycan sample. Highlighted additional components identified s a result of the extended mass range." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Q_Da_II_Mass_Detector_Selected_Ion_Recording_SIR_chromatogram_of_doubly_charged_components_of_a_glycan_sample_Highlighted_additional_components_identified_s_a_result_of_the_extended_mass_range_ac0160e74d.jpg 238w," sizes="100vw" width="1347" height="883"></p><h3><strong>Unparalleled Robustness for More Qualitative and Quantitative Performance</strong></h3><h4><strong>Reduce the risk of genotoxic impurities formation in drug manufacturing</strong></h4><p data-start="0" data-end="296">Support risk assessment through routine monitoring of excipients and raw materials in drug manufacturing. Accessible, regulatory compliant-ready LC-MS solutions provide an efficient and cost-effective approach in mitigating the risk of impurity formation during the manufacture of drug product.</p><p data-start="298" data-end="768">Nitrite, a critical risk factor in N-Nitrosamine formation, presents as an impurity in pharmaceutical excipients, often in parts per million (ppm). The ACQUITY QDa II Mass Detector is a robust and reliable solution for routine analysis of nitrite in excipients. With automated resolution, tuning, and calibration during start-up, the ACQUITY QDa II Mass Detector eliminates the need for analyst intervention, ensuring seamless operation and precise results every time.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Q_Da_II_Mass_Detector_Over_29_days_of_rigorous_testing_it_flawlessly_executed_approximately_6000_injections_with_minimal_downtime_02a496f422.jpg" alt="Waters ACQUITY QDa II Mass Detector: Over 29 days of rigorous testing, it flawlessly executed approximately 6000 injections with minimal downtime." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Q_Da_II_Mass_Detector_Over_29_days_of_rigorous_testing_it_flawlessly_executed_approximately_6000_injections_with_minimal_downtime_02a496f422.jpg 245w," sizes="100vw" width="1185" height="529"></p><p data-start="770" data-end="1012" data-is-last-node="" data-is-only-node="">Empower CDS reporting functionality offers simple reviewing of excipient nitrite concentration within a sample batch. This allows for fast and comprehensive decision making, while ensuring compliance and data integrity within your laboratory.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Q_Da_II_Mass_Detector_Example_of_Empower_CDS_generated_data_report_for_nitrite_content_in_a_maize_starch_sample_2f106193ee.jpg" alt="Waters ACQUITY QDa II Mass Detector: Example of Empower CDS generated data report for nitrite content in a maize starch sample." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Q_Da_II_Mass_Detector_Example_of_Empower_CDS_generated_data_report_for_nitrite_content_in_a_maize_starch_sample_2f106193ee.jpg 245w," sizes="100vw" width="937" height="585"></p><h3><strong data-start="0" data-end="62">Improving Efficiency with a More Sustainable Mass Detector</strong></h3><h4><strong>Low operational costs and environmental footprint</strong></h4><p data-start="123" data-end="346"><strong>As a leading technology innovator in chromatography, mass spectrometry, and thermal analysis instruments and software, Waters shares a common mission with our customers: to leave the world a better place than we found it.</strong></p><p data-start="348" data-end="674" data-is-last-node="" data-is-only-node="">Many of our customers are actively working to address environmental sustainability in balance with the need to continually reduce operational costs. Waters has addressed these challenges by providing an instrument with low electricity consumption and BTU/hr output – lessening the need for air conditioning and lowering costs.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Q_Da_II_Mass_Detector_Improving_Efficiency_with_a_More_Sustainable_Mass_Detector_Low_operational_costs_and_environmental_footprint_a9e182ea1f.jpg" alt="Waters ACQUITY QDa II Mass Detector: Improving Efficiency with a More Sustainable Mass Detector. Low operational costs and environmental footprint." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Q_Da_II_Mass_Detector_Improving_Efficiency_with_a_More_Sustainable_Mass_Detector_Low_operational_costs_and_environmental_footprint_a9e182ea1f.jpg 245w," sizes="100vw" width="1124" height="389"></p><p><strong>*</strong>From competitor A Specification Sheet.</p><p><strong>**</strong>From competitor B Site Preparation Checklist</p><h3><strong>Unrivaled Support</strong></h3><h3><strong>Ensure your success with world-renowned services</strong></h3><p data-start="77" data-end="464" data-is-last-node="" data-is-only-node="">Waters Service and Support helps maintain peak system performance, minimize downtime, address scientific challenges, and meet compliance requirements.&nbsp;</p><p>Waters award-winning consistent quality support, professional services, and education ensure your success wherever your laboratory is located in the world. With Waters service and support offerings<strong>*</strong> for your ACQUITY QDa II Mass Detector, you can</p><h4><strong data-start="0" data-end="30">GET UP AND RUNNING QUICKLY</strong></h4><p data-start="0" data-end="235">Get the onsite training and consultation you need to integrate the ACQUITY QDa II Mass Detector into your laboratory and assist with data migration and method transfer needs with Waters Professional Services.</p><h4><strong data-start="237" data-end="276">MEET YOUR LAB’S UNIQUE REQUIREMENTS</strong></h4><p data-start="237" data-end="460">Protect your instrument investment with the comprehensive portfolio of service plans from Waters FlexCHOICE™, which provides access to the most in-depth and up-to-date knowledge of the advanced science and technologies within Waters systems.</p><h4><strong data-start="462" data-end="487">FACILITATE COMPLIANCE</strong></h4><p data-start="462" data-end="635">Simplify the process of qualification, and record-keeping so that your business can focus on delivering products to market with Waters Compliance Services – so you can meet the regulations in your industry and in the countries where you conduct business.</p><h4><strong data-start="637" data-end="671">REDUCE TOTAL COST OF OWNERSHIP</strong></h4><p data-start="637" data-end="864">FlexCAPITAL™ <strong>**</strong> is designed to support continuous laboratory operation while satisfying the budgeting challenges of a constantly shifting landscape. Minimize total cost of ownership while optimizing instrument performance and protecting your organization from security risks associated with outdated software platforms.</p><h4><strong data-start="866" data-end="903">LEVERAGE YOUR EXISTING TECHNOLOGY</strong></h4><p data-start="866" data-end="1104" data-is-last-node="" data-is-only-node="">With the FlexUP™ Technology renewal program, you can upgrade your older single quadrupole mass spectrometry system to the ACQUITY QDa II Mass Detector -- improving performance, results, and productivity while controlling costs and mitigating compliance risk.</p><p><strong>*</strong> Availability of offerings varies by country. Contact Waters or your local Waters representative for details<br><strong>**</strong> FlexCAPITAL payment plan options and availability may vary by country. Other restrictions may apply.</p>

Waters RADIAN ASAP Direct Mass Detector

Combining flexibility, ease of operation, and speed without the need for complex sample preparation, separation or extensive MS experience, the RADIAN ASAP helps you and your laboratory achieve more.

<div><div id="title-a9e634f6cb" data-locator="title-with-text"><h3><strong>The power of knowing now</strong></h3></div></div><div><div id="text-c687cac6aa" data-locator="text"><p><strong>Whether you are looking to improve your drug discovery cycle, expand your client services, or simply become more competitive in your turnaround times, integrating direct mass spectrometry (MS) analysis can drive multiple system-wide efficiencies helping to achieve your operational goals.</strong></p><p>Combining flexibility, ease of operation, and speed without the need for complex sample preparation, separation or extensive MS experience, the RADIAN ASAP helps you and your laboratory achieve more.</p><ul><li>Simple operation and data interpretation</li><li>Minimal sample preparation</li><li>No separation required</li><li>Real-time results and classification</li></ul><figure class="image"><img style="aspect-ratio:454/321;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_RADIAN_ASAP_7cfe24b23d/Waters-RADIAN-ASAP_s.webp" alt="Waters RADIAN ASAP Direct Mass Detector" width="454" height="321"></figure><h3><strong>Overview</strong></h3><div data-locator="section-container-body"><div><div><div data-locator="layoutcontainer-"><div><div id="text-6b896f6da4" data-locator="text"><ul><li>Ensure users get up and running quickly with RADIAN ASAP’s easy to learn and fully automated set up, streamlined workflow, and minimal training requirements</li><li>Minimize sample prep with direct sampling onto glass probe</li><li>Minimize the need for solvent use and disposal with no chromatography</li><li>Save time with 30 second analysis and real-time sample classification</li></ul></div></div><div><div id="text-161a2a5c01" data-locator="text"><h4><strong>Recommended Use</strong></h4><p>For rapid, easy, and low-cost analysis of liquids and solids.</p><div><div id="text-4973311325" data-locator="text"><h3 data-locator="modal-title"><strong>Compact without compromise</strong></h3><p>The RADIAN ASAP is a novel, dedicated direct analysis system specifically designed for rapid, easy and low-cost analysis of liquids and solids. Engineered using proven and robust single quadrupole mass spectrometry technology combined with the Atmospheric Pressure Solids Analysis Probe (<a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/us/en/services/instrument-services/instrument-upgrades/mass-spectrometry-ms-upgrades/atmospheric-solids-analysis-probe.html" data-di-id="di-id-70d78c77-7e033f9d">ASAP</a>), the RADIAN ASAP delivers quality and ease of use in a compact footprint.&nbsp;</p><p>This single quadrupole mass detector provides high quality mass spectral data, without the need for any special training or expertise, eliminating any need to contract out and wait for results from specialist analytical service laboratories.</p></div></div><div><div id="text-08366f2c0d" data-locator="text"><h3 data-locator="modal-title"><strong>Flexible workflow solutions in 4 simple steps</strong></h3><p>Operation of the RADIAN ASAP is simple and intuitive, allowing users to generate results with minimal or no sample preparation, making it an ideal tool for laboratories to make informed decisions. Capable of ionizing molecules directly from a liquid or solid makes the system available to a wide range of applications and workflows.</p><h4><strong>Generate results in 4 simple steps:</strong></h4><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_RADIAN_ASAP_analyza_ve_4_jednoduchych_krocich_a997bfddda/Waters-RADIAN-ASAP-analyza-ve-4-jednoduchych-krocich.jpg" alt="Waters RADIAN ASAP Direct Mass Detector: Flexible workflow solutions in 4 simple steps" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_RADIAN_ASAP_analyza_ve_4_jednoduchych_krocich_a997bfddda/thumbnail_Waters-RADIAN-ASAP-analyza-ve-4-jednoduchych-krocich.jpg 245w," sizes="100vw" width="1683" height="490"></p><h3><strong>Ideal for numerous application requirements</strong></h3><p><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/nav.htm?cid=135078611" data-di-id="di-id-7f758d90-ccee23de"><strong>Rapid triage of seized drug materials for Forensics</strong></a><i>&nbsp;<strong>—</strong>&nbsp;</i>RADIAN ASAP and LiveID ensure crime labs can quickly screen samples against a library of known compounds for rapid, confident identification of illicit drugs. The sensitivity and selectivity of mass spectrometry provides confidence in detecting drugs with an easy, efficient triage workflow.</p><p><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/nav.htm?cid=134528742" data-di-id="di-id-3a3c46e4-ccee23de"><strong>Assess food integrity for Food &amp; Environmental</strong></a>&nbsp;<strong>—</strong> The threat posed by food fraud has created additional demands on both the food industry and regulators to protect food consumers and maintain brand reputation. RADIAN ASAP and LiveID offer a powerful combination of mass spectrometry and chemometric modeling, allowing users to easily and efficiently screen samples and make quicker decisions.</p><p><a target="_blank" rel="noopener noreferrer" href="https://www.tainstruments.com/radian-asap-direct-mass-detector/" data-di-id="di-id-2fac456-44144a9d"><strong>Fast chemical analysis for improved formulation testing in Chemical and Materials</strong></a><i>&nbsp;<strong>—</strong>&nbsp;</i>RADIAN ASAP and IonLynx supports quality control (QC) and development labs in the chemical industry to reduce costs and increase efficiencies. Streamline workflows like fast chemical analysis for improved formulation testing or&nbsp;material release testing. Features including thermal gradient analysis are ideal for the complex samples in the chemical industry.</p><p><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/nav.htm?cid=134751395" data-di-id="di-id-76921eaa-ccee23de"><strong>Discovery reaction monitoring&nbsp;for Pharma</strong></a>&nbsp;<strong>—</strong> The demand to accelerate the drug discovery and development process has never been higher.&nbsp;RADIAN ASAP provides synthetic chemists easy access to mass spectral data for near-instantaneous assessment of reaction progress and identification of purification fractions, increasing lab efficiency.</p><div><div><div><div id="text-8b0fa56c8c" data-locator="text"><p><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/nav.htm?cid=134971387" data-di-id="di-id-10e51f17-ccee23de"><strong>Undergraduate teaching&nbsp;and method development&nbsp;in Academia</strong></a><strong> —&nbsp;</strong>Simplicity and ease of use makes RADIAN ASAP the ideal tool for busy academic laboratories that need a robust and reliable solution.</p><figure class="image"><img style="aspect-ratio:474/308;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_RADIAN_ASAP_2_87ddc46f15/Waters-RADIAN-ASAP-2_s.webp" alt="Waters RADIAN ASAP Direct Mass Detector" width="474" height="308"></figure><div><div id="text-a5e5e26910" data-locator="text"><h3 data-locator="modal-title"><strong>Software solutions for your data requirements</strong></h3><p><strong>RADIAN ASAP</strong> is compatible with software solutions for rapid interpretation and classification as well as automated data processing and reporting.</p><p>For customers investigating the authenticity, adulteration, and quality of food or raw materials, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?mainauthorItems=5&amp;search=liveid"><strong>LiveID</strong></a> uses statistical models to classify samples. First, authentic or verified samples are used to create and validate a statistical model. The validated model can then be used with test samples and generate live classifications with a simple yes/no answer output. LiveID can also do real time <strong>library</strong> matching workflows, where the software matches all compounds in the library against each sample analyzed, giving a score out of <strong>1000</strong>, where values close to 1000 indicate the compound of interest is likely in the sample and lower scores indicate unlikely presence in the sample.</p><p><strong>OpenLynx</strong> processing provides user customizable processing capabilities to generate automated mass confirmation reports in either pdf, printed or browser format.&nbsp;</p><p><strong>IonLynx</strong> allows users to determine levels and relative ratios of analytes of interest in complex samples to aid decision making in QC and formulation monitoring. IonLynx provides automated processing and reporting of non-chromatographic data sets, such as those generated by RADIAN ASAP.</p></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Thermo Scientific ISQ™ EC/EM Single Quadrupole Mass Spectrometer

Enhance your IC or LC analysis with ISQ EC/EM mass spectrometers. Enjoy fast setup, high sensitivity, and reliable quantification—even in complex samples—with easy, seamless system integration.

<h4><strong>Thermo Scientific™ ISQ™ EC Single Quadrupole Mass Spectrometer</strong></h4><p><strong>Add mass spectrometry (MS) to your IC and LC analyses for access to the valuable data that only MS can provide. The new, easy-to-use Thermo Scientific™ ISQ™ EC Single Quadrupole Mass Spectrometer seamlessly integrates with ion chromatography (IC) and high performance liquid chromatography (HPLC) systems. Both novices and experts alike can quickly master MS to gain more insights from every sample.</strong></p><h5><strong>Gain more insights</strong></h5><ul><li>Higher sensitivity and more accurate quantitation</li><li>Chromatographic peak mass confirmation, eliminating false negatives and false positives</li></ul><h5><strong>Resolve complexity</strong></h5><ul><li>Improved resolution of analytes in complex matrices</li><li>Better selectivity</li><li>Resolve co-eluting peaks using their mass-to-charge ratio</li></ul><h5><strong>Easily mastered</strong></h5><ul><li>Save time spent on user training with integrated tools to help master MS</li><li>Experience hassle-free, seamless integration with your IC or LC system</li><li>Save time using the Thermo Scientific™ <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Chromeleon™ Chromatography Data System (CDS) software</strong></a> for data analysis, which also has embedded control of the ISQ EC mass spectrometer</li></ul><h4><strong>Thermo Scientific™ ISQ™ EM Single Quadrupole Mass Spectrometer</strong></h4><p>Adding mass spectrometry (MS) to your liquid chromatography (LC) analyses gives you access to the valuable data that only MS can provide. The new, easy-to-use ISQ™ EM Single Quadrupole Mass Spectrometer seamlessly integrates with LC systems for reliable, robust, and easy LC-MS routine analysis with an extended mass range for more flexibility. Detect and quantify a variety of analytes by choosing to use either heated electrospray ionization (HESI) or atmospheric pressure chemical ionization (APCI). Integrated software allows both novices and experts to quickly master MS to gain more insights from every sample.</p><h5><strong>Gain more insights</strong></h5><ul><li>Extended mass range enables you to detect and quantify small and large molecules</li><li>Durable atmospheric pressure ionization (API) source with two interchangeable probes included, enabling HESI or dual HESI/APCI</li><li>Sensitive and accurate quantitation of more samples</li><li>Chromatographic peak mass confirmation to eliminate false negatives and false positives</li></ul><h5><strong>Resolve complexity</strong></h5><ul><li>Consistent response even with complex matrices</li><li>Better selectivity and sensitivity with chromatographic peak mass confirmation</li><li>Resolution of co-eluting peaks via mass-to-charge ratio</li></ul><h5><strong>Easy mastery</strong></h5><ul><li>Reduce time spent on user training with integrated tools to help master MS</li><li>Unique software translates analyte physical properties into optimal method parameters, helping novice and experts develop methods and improve productivity</li><li>Hassle-free, seamless integration with existing LC systems</li><li>Facilitate data analysis with Thermo Scientific™ <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Chromeleon™ Chromatography Data System (CDS) software</strong></a>, which features embedded control of the ISQ EM mass spectrometer</li></ul><h4><strong>Key Features ISQ™ EC/EM Single Quadrupole Mass Spectrometers:</strong></h4><ul><li><strong>Mass Range:</strong>&nbsp;<ul><li><strong>EC:</strong> 10–1250 m/z with unit mass resolution</li><li><strong>EM:</strong> 10–2000 m/z with unit mass resolution</li></ul></li><li><strong>Polarity Switching:</strong> 25 ms (in HESI mode)</li><li><strong>Scan Rate:</strong> Up to 20,000 Da/sec</li><li><strong>Sensitivity:</strong><ul><li><i>HESI Positive:</i> 10 pg Reserpine, 400:1 RMS at 400 μL/min</li><li><i>HESI Negative:</i> 20 pg p-Nitrophenol, 500:1 RMS at 400 μL/min</li></ul></li><li><strong>Gas Requirements:</strong> Nitrogen (≥ 99% purity), 30 L/min @ 90–110 psig</li><li><strong>Power Supply:</strong> 100–240 V, 50/60 Hz</li><li><strong>Dimensions:</strong> 52 (H) × 42 (W) × 91 (D) cm</li><li><strong>Weight:</strong> Approx. 71 kg (157 lb)</li><li><strong>Unit Size:</strong> Each</li></ul>

Products focused on LC/SQ - page 1

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