Wiley, a global leader in authoritative content and research intelligence, launched Wiley Analytical Lab, a new software-as-a-service (SaaS) platform that gives researchers access to its trusted spectral data, compound identification tools, and analytical data management capabilities through one modern online environment.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Wiley_Analytical_Lab_acffcc9960.jpg" alt="Wiley: Wiley Analytical Lab" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Wiley_Analytical_Lab_acffcc9960.jpg 153w," sizes="100vw" width="662" height="676">Scientific research increasingly depends on both trusted reference data and the ability to manage and share the data generated in the lab. Yet these activities often take place across separate systems, locally installed software, and disconnected repositories. Wiley Analytical Lab addresses that problem by making critical analytical capabilities easier to access across institutions and research teams, while supporting the path from spectral search and identification through data management and publication.Wiley Analytical Lab gives researchers a one-stop shop where they can easily access the following trusted Wiley tools to perform multiple tasks:<ul><li>SpectraBase — Search millions of trusted reference spectra&nbsp;</li><li>KnowItAll AnyWare — Upload experimental spectra and identify unknown compounds&nbsp;</li><li>Wiley Data Hub — Manage, validate, publish, and share analytical datasets&nbsp;</li></ul>The platform is built on Wiley’s expertise in spectral data and scientific publishing, helping researchers work more efficiently and with greater confidence.The launch advances Wiley’s strategy to transform authoritative scientific knowledge and data into scalable, workflow-relevant digital solutions. By delivering these capabilities through a SaaS platform, Wiley can broaden access today while creating a foundation for continued product expansion and future innovation across the research workflow.“Wiley Analytical Lab represents an important step in how we turn trusted scientific data into intelligence researchers can use directly in their work,” said Armughan Rafat, Wiley senior vice president and chief AI and data analytics officer. “Researchers need more than just access to information; they need modern, connected tools that help them move from an unknown sample to a confident answer and from experimental data to published, reusable science. By combining Wiley’s trusted spectral content, analytical capabilities, and publishing expertise in a scalable SaaS environment, we are helping researchers work faster while strengthening the foundation for future data- and AI-driven innovation.”Unlike fragmented or instrument-specific solutions, Wiley Analytical Lab provides a vendor-neutral online environment that supports researchers working across instruments, formats, locations, and teams. The browser-based SaaS platform complements <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7899">Wiley’s recently launched spectroscopy API portfolio</a> and builds on capabilities available in its expert desktop KnowItAll software.Wiley Analytical Lab will initially be available through KnowItAll Campus-Wide Solutions for universities and KnowItAll Complete Multi-User Licensing for corporate and government organizations. &nbsp;<blockquote>For more information about Wiley Analytical Lab, please visit <a target="_blank" rel="noopener noreferrer" href="https://analyticallab.wiley.com">this website</a></blockquote><h4>About Wiley</h4>Wiley is a global leader in authoritative content and research intelligence for the advancement of scientific discovery, innovation, and learning. With more than 200 years at the center of the scholarly ecosystem, Wiley combines trusted publishing heritage with AI-powered platforms to transform how knowledge is discovered, accessed, and applied. From individual researchers and students to Fortune 500 R&amp;D teams, Wiley enables the transformation of scientific breakthroughs into real-world impact. From knowledge to impact—Wiley is redefining what's possible in science and learning.

Wiley Launches Wiley Analytical Lab

Simulated moving bed (SMB) chromatography offers an efficient approach to continuous separation, but translating the underlying principle into a reliable laboratory or pilot-scale process requires more than a suitable column. KNAUER's AZURA® SMB systems bring together modular chromatography hardware, flexible column configurations, and dedicated PurityChrom MCC software to make continuous purification accessible from method development through pilot production.For laboratories exploring SMB during preparative method development, the key question is often how the theoretical movement of the stationary phase can be reproduced in a functioning instrument. KNAUER addresses this challenge with ready-to-use systems built around components already used in its AZURA preparative chromatography portfolio. The company has supplied laboratory- and pilot-scale SMB equipment for almost three decades.<h4>From the SMB principle to an operating system</h4>The AZURA SMB architecture uses a standardized arrangement of four pumps and seven multiposition valves. Three pumps—assigned to the extract, raffinate, and eluent streams—operate within the SMB cycle, while a fourth pump introduces the feed from outside the cycle.The multiposition valves route the mobile phase between the pumps and separation columns. Four eight-port valves are installed at the pump outlets, and three valves are positioned at the pump inlets. The feed pump is the exception: its inlet is not connected to a multiposition valve.In the conventional eight-column arrangement, the columns form four separation zones, with two columns in each zone. This layout provides the foundation for several AZURA SMB configurations.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_1_SMB_concept_with_eight_columns_two_in_each_of_the_four_zones_of_the_SMB_cycle_The_four_pumps_and_seven_multposition_valves_and_their_placement_in_the_SMB_cycle_are_highlighted_2367007ad5.jpg" alt="KNAUER: Figure 1: SMB concept with eight columns, two in each of the four zones of the SMB cycle. The four pumps and seven multposition valves and their placement in the SMB cycle are highlighted" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_1_SMB_concept_with_eight_columns_two_in_each_of_the_four_zones_of_the_SMB_cycle_The_four_pumps_and_seven_multposition_valves_and_their_placement_in_the_SMB_cycle_are_highlighted_2367007ad5.jpg 174w," sizes="100vw" width="1024" height="920"><h4>AZURA SMB systems for laboratory and pilot applications</h4>KNAUER offers several versions of the same underlying SMB concept, allowing users to select the system that best matches their process scale and purification requirements.<ul><li>AZURA Lab SMB System: Available with stainless-steel or biocompatible fluidic components, this configuration is intended for small-scale SMB method development and gram-scale purification of small molecules or biomolecules.</li><li>AZURA Pilot SMB System: Designed for continuous separation of binary mixtures at gram-to-kilogram scale, with a focus on productivity and extended operation.</li><li>AZURA Pilot SMB High-Flow System: A higher-capacity pilot configuration supporting continuous flow rates of up to 400 mL/min in Zone 1 and feed flow rates of up to 100 mL/min.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_2_KNAUER_SMB_systems_356ed576ae.jpg" alt="KNAUER: Figure 2: KNAUER SMB systems – AZURA Lab scale system (left) &amp; AZURA Pilot scale system (right)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_2_KNAUER_SMB_systems_356ed576ae.jpg 245w," sizes="100vw" width="996" height="627">The available operating pressure and flow capacity depend on the selected version. Standard eight-column systems can operate at pressures up to 130 bar, while the maximum pressure is lower in the higher-flow pilot configurations. Column temperature can also be selected according to the application.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Table_1_9456d3d26f.jpg" alt="KNAUER: Table 1" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Table_1_9456d3d26f.jpg 245w," sizes="100vw" width="1302" height="641"><h4>Flexible distribution of columns between SMB zones</h4>A major advantage of the AZURA design is the ability to adapt the number of columns assigned to each zone. The conventional arrangement is 2:2:2:2, meaning that all four zones contain two columns. This configuration is commonly used for classical SMB separations.When a separation requires greater capacity in the central zones, the column distribution can be changed to 1:3:3:1. In this arrangement, Zones 2 and 3 each contain three columns, while Zones 1 and 4 contain one column. The adjustment can be made through the control software without changing the basic eight-column hardware layout.KNAUER also supports configurations with fewer columns:<ul><li><div><div>1:2:2:1: Six columns distributed across the four zones.</div></div></li><li><div><div>1:1:1:1: Four columns, with one column assigned to each zone.</div></div></li></ul>Reducing the total number of columns lowers the quantity of stationary phase needed and can therefore help reduce operating expenses. Unlike switching between eight-column arrangements, however, six- and four-column setups require both software changes and manual modifications to the capillary connections.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_3_Different_column_set_up_of_the_KNAUER_SMB_systems_9294b905fd.jpg" alt="KNAUER: Figure 3: Different column set-up of the KNAUER SMB systems; A) 2:2:2:2 columns (screenshot from PurityChrom MCC plus software)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_3_Different_column_set_up_of_the_KNAUER_SMB_systems_9294b905fd.jpg 174w," sizes="100vw" width="826" height="740"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_3_2_0f47cd7821.jpg" alt="KNAUER: Figure 3: Different column set-up of the KNAUER SMB systems; B) 1:3:3:1 columns (screenshot from PurityChrom MCC plus software)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_3_2_0f47cd7821.jpg 169w," sizes="100vw" width="935" height="863"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_3_3_1510da9c28.jpg" alt="KNAUER: Figure 3: Different column set-up of the KNAUER SMB systems; C) 1:2:2:1 (screenshot from PurityChrom MCC plus software)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_3_3_1510da9c28.jpg 177w," sizes="100vw" width="838" height="740"><h4>PurityChrom MCC: Software for continuous chromatography</h4>An SMB system depends on accurate coordination of its pumps, valves, columns, and process conditions. For this reason, KNAUER developed PurityChrom MCC, a version of its purification software tailored to continuous chromatography.The software displays a graphical representation of the fluidic system, giving users a clear view of the process and access to the relevant device controls. This visual approach simplifies the operation of a system in which several flow paths and switching events must work together.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_4_SMB_system_visualization_a24c729478.jpg" alt="KNAUER: Figure 4: SMB system visualization with functionalized operation buttons in PurityMCC plus software" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_4_SMB_system_visualization_a24c729478.jpg 174w," sizes="100vw" width="739" height="663">The software provides several tools for method development and routine operation:<ul><li>Adjustments during a run: Instruments shown in the fluidic diagram can be controlled individually, allowing operators to modify and optimize process conditions while the separation is underway.</li><li>Assistance with method setup: An SMB parameter wizard helps users create methods and refine operating parameters, including adjustments during an ongoing process.</li><li>Monitoring and data handling: The software records, stores, and processes warnings, error messages, UV and RI detector signals, flowmeter readings, and other analog inputs.</li><li>Support for regulated work: PurityChrom MCC complies with the requirements of 21 CFR Part 11.</li><li>Continuous flow verification: Pilot systems include four flowmeters, one for each pump, so that deviations from the intended flow rates can be identified and addressed in real time. These flowmeters can also be obtained separately for laboratory-scale systems.</li></ul>An operating-point calculator is another feature available to support the development and optimization of SMB methods.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_5_SMB_Operating_point_calculator_65b9945693.jpg" alt="KNAUER: Figure 5: SMB Operating point calculator (screenshot PurityMCC plus software)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_5_SMB_Operating_point_calculator_65b9945693.jpg 245w," sizes="100vw" width="645" height="361"><h4>Connecting method development with continuous production</h4>The combination of modular hardware and purpose-built software makes the AZURA SMB platform adaptable to different separation tasks. A method can be developed on a laboratory system and subsequently transferred toward pilot-scale operation using the same overall system concept.The ability to change column distributions is particularly useful when balancing separation performance, stationary-phase consumption, and process productivity. At the same time, software visualization and continuous monitoring provide operators with greater control over an otherwise complex chromatographic process.These capabilities support the use of SMB in applications such as pharmaceutical production, food processing, and fine-chemical purification. Examples of separation tasks include sugar fractionation and the isolation of cannabinoids.<h4>Conclusion: A modular approach to SMB separation</h4>KNAUER's AZURA SMB range translates the principles of simulated moving bed chromatography into configurable equipment for continuous purification. Its practical strengths lie in the integration of four-pump, seven-valve hardware, adaptable zone arrangements, and the PurityChrom MCC control environment.Users can work with established eight-column configurations, redistribute columns to meet more demanding separation needs, or reduce the column count when the process allows it. Combined with software-assisted method development, process monitoring, and options for laboratory and pilot operation, this makes AZURA SMB a flexible solution for moving continuous chromatography from experimental development toward practical production.

How KNAUER transforms SMB chromatography from a theoretical concept into hardware

News from LabRulezLCMS Library - Week 46, 2026

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Organomation NITRO-GEN+ Nitrogen Generator

The NITRO-GEN+ Nitrogen Generator is designed to satisfy the needs of the LC-MS and sample preparation fields.

The NITRO-GEN+ Nitrogen Generator is designed to satisfy the needs of the LC-MS and sample preparation fields. The NITRO-GEN+ is compatible with all Organomation nitrogen evaporators up to 100 sample positions, along with most LC-MS analyzers on the market. It relies on Pressure Swing Adsorption (PSA) technology to separate nitrogen from the air. The unit uses molecular sieves to remove oxygen, water, and trace hydrocarbons, leaving a stream of high purity nitrogen gas. Nitrogen is produced by utilizing a combination of this Carbon Molecular Sieve technology along with high and low pressure compressors.This unique technology allows the nitrogen to be produced at a low pressure and an ambient temperature, eliminating the need for high pressure cylinders which can be dangerous for the technicians handling them. The low pressure also ensures a longer compressor life, which reduces the time and money spent on regular maintenance. The generator's simple installation and operation combined with its superior reliability makes the NITRO-GEN+ a staple in any laboratory.<h4>Standard features</h4><ul><li>Integrated low noise, oil free compressors</li><li>On-demand supply 24/7</li><li>Proprietary carbon molecular sieve technology</li><li>Complete "plug and play" LC-MS solution</li><li>Two-year complete product warranty or 8,000 hour run-time warranty</li></ul><h4>Compatible features</h4><ul><li>All Organomation evaporators up to 100 sample positions</li><li>Most LC-MS analyzers on the market</li></ul><h4>Specification</h4><h5>Key Features:</h5><ul><li>Flow Rate: Up to 35 L/min</li><li>Nitrogen Purity:<ul><li>Up to 99% at ≤ 25 L/min</li><li>Up to 98% at &gt; 25 L/min</li></ul></li><li>Dewpoint: -58 °F (-50 °C)</li><li>Output Pressure: 0 – 116 PSI (0 – 8 bar)</li><li>Warm-Up Time: 20 minutes</li><li>Technology: Carbon molecular sieve (CMS)</li></ul><h5>Electrical &amp; Safety:</h5><ul><li>Power Supply:<ul><li>110–120 V, 60 Hz</li><li>220–240 V, 50 Hz</li></ul></li><li>Total Wattage: 1800 W</li><li>Protection Rating:<ul><li>Electrical: IP20</li><li>Mechanical Impact: IK08</li></ul></li><li>Noise Level: 55 dBA at 1 meter</li></ul><h5>Dimensions &amp; Weight:</h5><ul><li>Size (W × D × H): 18.9 × 33 × 25 in (48 × 83.8 × 63.5 cm)</li><li>Weight: 198 lbs (90 kg)</li></ul><h5>Connections &amp; Certifications:</h5><ul><li>Outlet Connection: 6 mm OD compression or 1/4"</li><li>Certifications: CE, FCC, MET (UL and CSA compliant)</li></ul><h5>Environmental Specifications:</h5><ul><li>Operating Temperature: 59–95 °F (15–35 °C)</li><li>Relative Humidity:<ul><li>0–80% (non-condensing)</li><li>0–99% (with condensation drain)</li></ul></li><li>Altitude: &lt; 2000 m (800–1150 hPa)</li></ul>Warranty: 2 years or 8,000-hour runtime (whichever comes first)

Organomation NITRO-GEN Nitrogen Generator

The NITRO-GEN generator was developed with Organomation’s nitrogen evaporators in mind to provide nitrogen generation for sample concentration.

The NITRO-GEN generator was developed with Organomation’s nitrogen evaporators in mind to provide nitrogen generation for sample concentration. The generator is lightweight and easy to set up, requiring only a source of compressed air to run. This unit is an ideal choice for labs with an in-house compressed air source.The generator uses a hollow-fiber membrane to convert compressed air to a stream of 95-99% pure nitrogen gas. The hollow-fiber membrane consists of a series of narrow, semipermeable tubes in a porous membrane. As compressed air travels through the fibers, oxygen and water vapor permeate the membrane and are vented off, leaving a steam of high purity nitrogen gas. At up to 99% purity, the resulting nitrogen gas stream can be used in a variety of sample preparation applications.<h4>NITRO-GEN</h4>The NITRO-GEN produces up to 20 L/min of nitrogen gas and is recommended for evaporation of up to 48 sample positions.&nbsp;<h4>Standard features</h4><ul><li>Adjustable outlet pressure regulator, 0-100 psi</li><li>Dual Stage clean air filtration system</li><li>Requires an oil-less compressed air source</li></ul><h4>Advantages</h4><ul><li>Quick Start-Up Time - Nitrogen is produced instantly, no heat up time</li><li>Saves Energy - No electrical power needed</li><li>Engineered Design - Life expectancy is more than 10 years</li><li>Low Maintenance - Serviceable clean air filter</li><li>Compact and Lightweight - Small footprint conserves valuable bench space</li><li>Reduced CO2 Emissions - No heaters, less energy required</li></ul><h4>Specification</h4><h5>Key Features:</h5><ul><li>Flow Rate: Up to 20 L/min</li><li>Technology: Hollow-fiber membrane</li><li>Output Pressure: Adjustable 0 – 100 PSI</li><li>Electrical Requirements: None (no power required)</li><li>Noise Level: &lt; 40 dBA (virtually silent when connected to an instrument)</li></ul><h5>Inlet Air Requirements:</h5><ul><li>Maximum Inlet Pressure: 150 PSI (10.3 bar)</li><li>Particulate Filtration: ≤ 0.01 µm</li><li>Oil Vapor Content: &lt; 0.01 mg/m³ (&lt; 0.01 ppm)</li><li>Relative Humidity: &lt; 100% (non-condensing)</li><li>Air Quality: Clean, contaminant-free air</li></ul><h5>Environmental Conditions:</h5><ul><li>Operating Temperature: 36–122 °F (2–50 °C)</li><li>Ambient Pressure: Atmospheric</li></ul><h5>Dimensions &amp; Weight:</h5><ul><li>Size (W × D × H): 9.5 × 8 × 19.5 in (241 × 203 × 495 mm)</li><li>Weight: 13.25 lbs (6 kg)</li></ul>Warranty: 1 year

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