Toward Accurate Estimation of Extractable Organic Fluorine by Analysis of Fluoride Contamination in Extracts Using Gas Chromatography

Propionic Acid Outperforms Formic and Acetic Acid in MS Sensitivity for High-Flow Reversed-Phase LC-MS Bottom-Up Proteomics

<p><strong>In the week of August 31, the following webinars await you in the field of liquid phase and especially HPLC and LC/MS.</strong></p><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/webinars"><strong>👉 DETAILS AND REGISTRATION IN THE WEBINARS SECTION</strong></a></h4><p><strong>👉 Search and filter in the largest global database</strong> with over <strong>5 500 GC, LC, MS and spectroscopy webinars</strong>.</p></blockquote><h5><strong>1. Technology Networks: Modern Methods for Faster Microbial Analysis</strong></h5><ul><li>Tu, 1.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6454">Registration</a></li></ul><p>Struggling to choose the right technique for microbial testing? Learn how MALDI-TOF, FTIR, and automated DNA/RNA electrophoresis accelerate identification.</p><h5><strong>2. Phenomenex: Addressing LC Method Optimization - Scaling For Efficiency, Throughput And Reproducibility</strong></h5><ul><li>We, 2.9.2026 10:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6458">Registration</a></li></ul><p>Join this webinar on LC method optimization and scaling. Learn how column dimensions, particle morphology, and sample loading strategies maximize throughput and reproducibility.</p><h5><strong>3. Thermo Fisher Scientific: Proteoform Studio software, top down made simple</strong></h5><ul><li>We, 2.9.2026 14:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6459">Registration</a></li></ul><p>Learn how Thermo Scientific Proteoform Studio software simplifies top-down MS and intact protein analysis through integrated workflows, interactive deconvolution, and reporting.</p><h5><strong>4. Agilent Technologies: Targeted Hybridization Capture for Antimicrobial Resistance Surveillance in Complex Environmental Samples</strong></h5><ul><li>We, 2.9.2026 15:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6455">Registration</a></li></ul><p>Discover how Agilent SureSelect hybrid capture enhances antimicrobial resistance gene detection and characterization in complex environmental samples compared with shotgun NGS.</p><h5><strong>5. Thermo Fisher Scientific: Ask the Expert: What to expect from the new Thermo Scientific™ Orbitrap™ Excedion™ Hybrid mass spectrometers</strong></h5><ul><li>Th, 3.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6466">Registration</a></li></ul><p>Discover the new Orbitrap Excedion Hybrid Mass Spectrometer and learn how enhanced dynamic range, robust performance, and an upgradeable design support advanced HRAM workflows.</p><h5><strong>6. Waters Corporation: Informatics series #34 Ready for Self-Documenting Chromatography?</strong></h5><ul><li>Th, 3.9.2026 11:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6426">Registration</a></li></ul><p>Speed up root cause analysis with self-documenting LC and Empower software in this 30-minute Waters coffee break.</p><h5><strong>7. SciY/Mestrelab Research: From Legacy Workflows to Paperless Labs: Track Every Sample, Process, and Decision</strong></h5><ul><li>Th, 3.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6425">Registration</a></li></ul><p>Transform your lab from paper to digital. Learn how WebLab and LIMS workflows automate sample tracking and support laboratory compliance.</p><h5><strong>8. SelectScience: ADC characterization in one native LC-MS workflow</strong></h5><ul><li>Fr, 4.9.2026 17:00 CEST</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6460">Registration</a></li></ul><p>Simplify ADC characterization with native RP-LC-MS using Biozen® columns to determine DAR, proteoforms, and positional isomers without buffer exchange.</p>

Webinars LabRulezLCMS Week 36/2026

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Thermo Scientific Vanquish Charged Aerosol Detectors

Thermo Scientific Vanquish CAD detectors deliver near-universal detection with high sensitivity, wide dynamic range, gradient compatibility, and compliance-ready design.

<p><strong>Expand your detection range and achieve accurate quantitation in High-Performance Liquid Chromatography (HPLC) with the near-universal Charged Aerosol Detector (CAD). Featuring a wide linear and dynamic range along with a uniform response independent of chemical structure, Thermo Scientific™ Vanquish™ CAD systems allow you to measure virtually all non-volatile and many semi-volatile analytes at low-nanogram to sub-nanogram concentrations. Confidently quantify both trace impurities and highly concentrated active compounds in a single analysis.</strong></p><h3><strong>Key Benefits</strong></h3><ul><li><strong>Standard-free quantitation of unknowns</strong> – uniform response enables reliable single-calibrant quantitation</li><li><strong>Superior sensitivity</strong> – 10× lower LODs compared to ELSD, LOQs as low as 1–20 ng on-column</li><li><strong>Wide dynamic range</strong> – linear up to 2 orders of magnitude, dynamic up to 4 orders</li><li><strong>Compatible with gradient elution</strong> – maintain uniform response using inverse gradient, unlike RID</li><li><strong>Integrated diverter valve</strong> – prevents contamination, directs unwanted matrix to waste, and improves quantitation of early-eluting compounds</li><li><strong>Compliance and data integrity</strong> – full qualification of method parameters, audited flow path control, and seamless integration with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Thermo Scientific Chromeleon™ CDS</strong></a></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Charged_Aerosol_Detectors_1_e135b2d6fe.jpg" alt="Thermo Scientific Vanquish Charged Aerosol Detectors" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Charged_Aerosol_Detectors_1_e135b2d6fe.jpg 209w," sizes="100vw" width="650" height="486"></p><h3><strong>Technical Features</strong></h3><ul><li><strong>Detection mode:</strong> Records up to 4 unique power values for optimal linear response</li><li><strong>Gas requirements:</strong> Nitrogen (recommended) or compressed air</li><li><strong>Dynamic range:</strong> Up to 4 orders of magnitude</li><li><strong>Data collection rate:</strong> Up to 200 Hz</li><li><strong>Compatibility:</strong> Designed for <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=37&amp;manufacturerItems=3&amp;search=Vanquish"><strong>Thermo Scientific™ Vanquish™ HPLC and UHPLC systems</strong></a>; integration with other systems possible</li><li><strong>Outputs:</strong> Digital and analog output options available</li><li><strong>Safety features:</strong> Overpressure relief, leak sensing, high-temperature shutoff, flood prevention, and diagnostic monitoring</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Charged_Aerosol_Detectors_3_335506f860.jpg" alt="Thermo Scientific Vanquish Charged Aerosol Detectors" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Charged_Aerosol_Detectors_3_335506f860.jpg 245w," sizes="100vw" width="650" height="378"></p><h3><strong>Product Portfolio</strong></h3><ul><li><strong>Vanquish CAD HP</strong> – broad temperature range (ambient, 10–100 °C), versatile high-performance configuration</li><li><strong>Vanquish CAD FP</strong> – fixed-point operation at defined set temperatures (ambient, 35 °C, 50 °C, 70 °C)</li><li><strong>Vanquish CAD H</strong> – heating-enabled design (ambient +5 to +100 °C)</li><li><strong>Vanquish CAD F</strong> – fixed-temperature options (35 °C, 50 °C, 70 °C)</li><li><strong>Vanquish CAD HP, Analog Output</strong> – full performance with analog signal output</li><li><strong>Vanquish CAD HP, Digital Output</strong> – full performance with digital data output</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Charged_Aerosol_Detectors_2_795050403c.jpg" alt="Thermo Scientific Vanquish Charged Aerosol Detectors" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Charged_Aerosol_Detectors_2_795050403c.jpg 245w," sizes="100vw" width="650" height="397"></p>

Waters Charged Aerosol Detector (CAD)

Waters Charged Aerosol Detector (CAD) enables universal quantitation of non-volatile and semi-volatile compounds independent of UV activity, with wide dynamic range and seamless integration with Empower™ Software.

<h3><strong>Expand Your Detection Range with a Detector Purpose-Built for Empower™ Software</strong></h3><p>Empower™ Software–based laboratories require detection solutions that are easy to adopt, robust, and capable of accurately quantifying non-volatile and semi-volatile compounds—regardless of chemical structure or UV activity.<br>The <strong>Waters Charged Aerosol Detector (CAD)</strong> is purposefully engineered to meet these demands, delivering universal, reliable detection fully integrated with Waters chromatography systems and Empower™ or MassLynx™ Software.</p><p>With a wide dynamic range exceeding four orders of magnitude, the Waters CAD enables <strong>simultaneous quantitation of low-level, non-UV-active analytes</strong>, along with related impurities and excipients, in a single run—helping laboratories reduce method development time, increase productivity, and improve process control.</p><h4><strong>Key Benefits</strong></h4><ul><li><strong>Universal detection without UV limitations</strong><br>Detect and quantify non-volatile and semi-volatile compounds independent of chromophore presence.</li><li><strong>Wide dynamic range (&gt;4 orders of magnitude)</strong><br>Confidently quantify trace-level components and major constituents simultaneously.</li><li><strong>Purpose-built for Empower™ Software</strong><br>Seamless integration into regulated workflows with Empower-based qualification and long-term software compatibility.</li><li><strong>Compatible across Waters LC platforms</strong><br>Integrates easily with Alliance™, Arc™, ACQUITY™ Arc, ACQUITY™ H-Class, ACQUITY™ I-Class, and UPLC™ Systems.</li><li><strong>Designed for robustness and ease of use</strong><br>Optimized hardware, simplified maintenance, and enhanced system protection features minimize downtime.</li></ul><h4><strong>Technical Specifications</strong></h4><h5><strong>Detector Performance</strong></h5><ul><li><strong>Detector flow rate:</strong><br>0.010–2.000 mL/min</li><li><strong>Dynamic range:</strong><br>Greater than four orders of magnitude (four individual power values)</li><li><strong>Sampling rate:</strong><br>Up to 200 Hz</li><li><strong>Number of channels:</strong><br>Four (4), supported by four (4) independent background current channels</li></ul><h5><strong>Temperature Control</strong></h5><ul><li><strong>Evaporation temperature:</strong><ul><li>Ambient (off)</li><li>Controlled range: 10 °C to 100 °C (0.1 °C increments)</li><li>Minimum of 5 °C above ambient</li></ul></li></ul><h5><strong>Gas Requirements</strong></h5><ul><li><strong>Inert gas supply:</strong><br>Nitrogen (recommended) or compressed air</li><li><strong>Inlet pressure:</strong><br>4.83–5.52 bar<br>(483–552 kPa, 70.0–80.0 psi)</li><li><strong>Gas consumption:</strong><br>Typically ≤ 5 L/min</li></ul><h5><strong>Diagnostics and Monitoring</strong></h5><ul><li><strong>Diagnostic channels include:</strong><ul><li>Nebulizer gas flow and pressure (psi)</li><li>Evaporator temperature (°C)</li><li>Ion trap voltage (V)</li><li>Charger current (µA)</li><li>Mixing chamber temperature (°C)</li></ul></li></ul><h5><strong>Electrical and Physical Specifications</strong></h5><ul><li><strong>Power requirements:</strong><br>100–240 VAC</li><li><strong>Dimensions:</strong><ul><li>Width: 34.3 cm (13.5 in)</li><li>Height: 20.8 cm (8.2 in)</li><li>Depth: 61.0 cm (24.0 in)</li></ul></li><li><strong>Biocompatible:</strong><br>No</li></ul><h5><strong>Software and System Compatibility</strong></h5><ul><li>Optimized for <strong>Empower™ Software</strong> and <strong>MassLynx™ Software</strong> control</li><li>Robust chromatography data system (CDS) communications to minimize downtime</li><li>Backward compatibility to <strong>Empower™ 3 Feature Release 4 Service Release 3 (SR3)</strong></li><li>Fully compatible with systems qualification and validation requirements in regulated environments</li></ul><h5><strong>Seamless Method Transfer Across Laboratories</strong></h5><p>The Waters CAD is designed to simplify method transfer within organizations and across external laboratories. It maintains method simplicity while adding enhanced tools for equivalency and reproducibility, reducing the need for revalidation when transitioning from legacy or third-party CAD solutions.</p><p>The intuitive <strong>ACQUITY™ console control panel</strong> enables straightforward operation and simplifies replacement of outdated technology across laboratory networks.</p><h5><strong>Designed for Ease of Use and Reliability</strong></h5><ul><li>Single filter manifold with <strong>push/pull filter replacement</strong></li><li>Easy-to-replace nebulizer for improved serviceability</li><li>Intelligent divert valve automatically sends flow to waste if gas pressure is lost or system errors occur</li><li>Enhanced <strong>leak detection and flood protection</strong>, safeguarding instruments in the event of CDS communication loss</li></ul><h5><strong>Recommended Use</strong></h5><p><strong>Accurate quantitation in:</strong></p><ul><li>HPLC, UHPLC, and UPLC separations</li><li>Preparative and purification workflows</li><li>Pharmaceutical QC and R&amp;D</li><li>Analysis of excipients, lipids, sugars, surfactants, and non-UV-active impurities</li></ul>

Products from category Charged Aerosol Detectors (CAD) - page 1

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Webinars LabRulezLCMS Week 36/2026

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