News from LabRulezGCMS Library - Week 39, 2026

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 21st September 2026? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>KNAUER </strong>and<strong> Shimadzu, </strong>technical note by <strong>Thermo Fisher Scientific </strong>and poster by <strong>Waters Corporation / SOFT!</strong></p><h3><strong>1. KNAUER: Precise Catechin Profiling in Various Types of Tea</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/VFD_0198_knauer_precise_catechin_profiling_in_various_types_of_tea_d607cde5ba.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Fresh tea leaves contain high concentrations of catechins, which have many beneficial properties. These include antioxidant, anti-inflammatory as well as antimicrobial effects, and it is even claimed that they have the potential to prevent cancer [1]. In addition, the taste and mouthfeel of a tea strongly depend on its catechin profile. The catechin content of tea leaves varies based on cultivation area, age and variety, as well as on how they are fermented, processed and packed. Therefore, the catechin content is an important marker for the quality of tea.&nbsp;</p><p>The analysis of catechins can be challenging. The structural similarity of the catechin isomers and other closely related compounds result in similar behavior and a difficult separation (Fig. 1). Catechins possess many phenolic hydroxyl groups, which are prone to secondary interactions, like hydrogen bonding. Classical as well as highly endcapped C18 columns offer only limited retention and selectivity for catechins. Therefore, the KNAUER column portfolio has been expanded to include a pentafluorophenyl (PFP)-modified stationary phase (<strong>Eurospher II 100-3 PFP column </strong>50 x 2 mm). It offers optimal separation of the catechins based on hydrophilic, hydrophobic and π-π-interactions. The column withstands acidic eluents (pH 1.5–10) as well as 100 % aqueous conditions, which are beneficial for the retention of hydrophilic compounds. The KNAUER Gradient Prediction Tool assisted with the challenging method development which is described in detail in the TechNote “The Gradient Prediction Tool: Method Development for the Separation of Catechins from Tea”. Here, the application of the optimized method for the identification and quantification of catechins in tea extracts is shown. The seven compounds specified in ISO-14502-2 (2005), as well as two additional catechins known as (+)-gallocatechin and (–)-gallocatechin gallate, were quantified.</p><h4><strong>MATERIAL AND METHODS</strong></h4><ul><li><strong>Pump: </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2374"><strong>P8.1L</strong></a>; high pressure gradient&nbsp;</li><li><strong>Liquid Handler:</strong> <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1454"><strong>LH 8.1L </strong></a>With FastWash station, and Robotic cooler. Loop: 20 µl.</li><li><strong>Thermostat: </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2376"><strong>CT 2.1L&nbsp;</strong></a></li><li><strong>Detector:</strong> <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2424"><strong>DAD 6.1L&nbsp;</strong></a></li><li><strong>Flow cell: </strong>Analytical LightGuide flow cell (50 mm, 6 µl)&nbsp;</li><li><strong>Software:</strong> ClarityChrom 10.1</li></ul><h4><strong>CONCLUSION&nbsp;</strong></h4><p>The application note demonstrates the reliable separation and quantification of catechins and caffeine in tea extracts using the new KNAUER PFP column. Using an optimised gradient predicted with the KNAUER Gradient Prediction Tool, nine tea-related compounds were separated in under 23 minutes. The tested tea samples showed different catechin content highlighting how strongly tea composition depends on the product type and processing.</p><h3><strong>2. Shimadzu: New Derivatization Method for Quantitative Analysis of Δ⁹-THC-COOH in Urine</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_01_01215_en_c98174629b.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>The risk of limited availability of stable isotope-labeled standards can be avoided by synthesizing internal standards through derivatization.&nbsp;</li><li>The derivatizing agent IPPAH and its corresponding stable isotope IPPAH-d6 can be synthesized easily and inexpensively from acetone (or acetone-d6).&nbsp;</li><li>This approach achieves sufficient sensitivity and quantitative accuracy for the determination of Δ⁹-THC-COOH in urine.</li></ul><p>In Japan, the Cannabis Control Act and the Narcotics and Psychotropics Control Act were amended in December 2024. While cannabis was legalized for industrial and medical uses, stricter cannabis regulations have been enacted to prevent harm from its abuse. The primary psychoactive cannabinoid, delta-9-tetrahydrocannabinol (Δ⁹-THC), is extensively metabolized in the body and is excreted mainly in urine and feces as 11-nor-9-carboxy-THC (Δ⁹-THC-COOH) and its glucuronide conjugates. Consequently, Δ⁹-THC-COOH must be analyzed to confirm cannabis use. For LC-MS/MS quantitation, the stable isotope-labeled internal standard Δ⁹-THC-COOH-d3 is commonly used to correct for matrix effects. However, most suppliers of stable isotope standards are located in the U.S., making these standards difficult to obtain due to import procedures. Furthermore, there may be additional importrelated supply risks for stable isotope standards in the future.&nbsp;</p><p>This Application News describes a technique for quantitating Δ⁹-THC-COOH using an internal standard that is synthesized easily and inexpensively by derivatization with IPPAH (1- isopropylpiperidine carboxylic acid hydrazide), which characteristically reacts with carboxyl groups, and its corresponding stable isotope IPPAH-d6.</p><h4><strong>Analysis Conditions&nbsp;</strong></h4><p>LC-MS/MS analysis conditions are shown in Table 1. The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=1&amp;search=Nexera+XR"><strong>Nexera XR</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=1&amp;search=LCMS-8050"><strong>LCMS-8050 systems</strong></a> were used.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>Derivatization with IPPAH and its stable isotope analog, IPPAHd6, enabled the simple and inexpensive preparation of an internal standard. This approach provides sufficient sensitivity and accuracy for the determination of Δ⁹-THC-COOH in urine. Most stable isotope-labeled standards are supplied by foreign manufacturers, creating a risk of delays or difficulties in procurement due to import/export regulations. By synthesizing the internal standard through derivatization, this risk can be minimized.</p><h3><strong>3. Thermo Fisher Scientific: High-throughput quantitative proteomics with Evosep Eno and the Orbitrap Astral Zoom Mass Spectrometer</strong></h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/tn_004544_ov_astralzoom_evosepeno_htp_proteomics_tn004544_na_en_f31db9084e.pdf"><strong>Full PDF for download</strong></a></li></ul><p>High-throughput proteomics is a critical enabling technology for large clinical studies, high-content drug screening, and systems biology research, allowing for comprehensive and quantitative analysis of complex proteomes across large sample cohorts within practical timeframes. As biological and translational studies expand in scale and complexity, the ability to generate deep and reproducible proteome measurements across thousands of samples has become increasingly essential for robust biomarker discovery, network-level systems modeling, and downstream analyses. In these contexts, accurate and precise protein quantitation must be maintained without sacrificing throughput, placing stringent demands on the performance and robustness of both LC instruments and mass spectrometers.&nbsp;</p><p>To meet these increasing analytical demands, the Evosep Eno was developed as a high‑throughput LC system that combines robustness, ease of use, and highly reproducible chromatography. It offers six standardized methods: 30, 60, 100, 200, 300, and 500 samples per day (SPD), allowing users to select the throughput that aligns best with their study goals.1 These predefined methods ensure consistent gradient delivery, highly stable retention times, and reproducible system performance across instruments and laboratories.2 By reducing LC‑related variability and simplifying everyday operation, the Evosep Eno offers a strong and consistent foundation for large‑scale proteomics workflows, particularly those relying on short gradients and high reproducibility required for downstream quantitative analysis.</p><h4><strong>Experiment</strong></h4><h5><strong>Instrumentation&nbsp;</strong></h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=291&amp;search=evosep+eno"><strong>Evosep Eno&nbsp;</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1959"><strong>Orbitrap Astral Zoom Mass Spectrometer&nbsp;</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2464"><strong>Thermo Scientific™ EASY-Spray™ Ion Source&nbsp;</strong></a></li><li>Evosep™ Pod for EASY-Spray Ion Source</li></ul><h5><strong>Software&nbsp;</strong></h5><ul><li>Biognosys Spectronaut® 19.7 software&nbsp;</li><li>MacCoss Lab Software Skyline-Daily V25.1</li></ul><h4><strong>Summary&nbsp;</strong></h4><h5><strong>Seamless and easy integration for high-throughput proteomics&nbsp;</strong></h5><p>Evosep Eno integrates seamlessly with the Orbitrap Astral Zoom Mass Spectrometer, supported by EASY-Spray source-compatible columns, emitters, and the Evosep Pod column oven for a simple, streamlined, high-throughput workflow.&nbsp;</p><h5><strong>Deep proteome coverage at 500 SPD&nbsp;</strong></h5><p>Optimized MS parameters for the standard 500 SPD Evosep Eno gradient enabled identification of more than 6,500 protein groups and 71,000 modified peptides from three replicates of 200 ng Pierce HeLa Digest/PRTC Standard.</p><h5><strong>Reproducible quantitation across standard gradients&nbsp;</strong></h5><p>Across all standard Evosep Eno gradients, the workflow delivered highly reproducible label-free quantification, with median protein group %CVs at or below 5.2%, while identifying more than 10,500 protein groups and 190,000 modified peptides from five replicates of 200 ng Pierce HeLa Digest/PRTC Standard at 30 SPD.&nbsp;</p><h5><strong>Robust chromatography at ultra-high throughput&nbsp;</strong></h5><p>Chromatographic performance remained stable and robust at 500 SPD, with nearly 100 consecutive runs showing PRTC retention time standard deviations below 0.4 seconds and a median of 6 DPPP.&nbsp;</p><h5><strong>Strong linearity for confident quantitation&nbsp;</strong></h5><p>Quantitative performance remained strong at 500 SPD, with PRTC peptides showing excellent linearity across the active gradient (R² &gt;0.98) when spiked from attomolar to femtomolar concentrations.</p><h3><strong>4. Waters Corporation / SOFT: COMPARATIVE EVALUATION OF HIGH RESOLUTION MASS SPECTROMETRY ACQUISITION STRATEGIES FOR THE DETECTION AND ANALYSIS OF ILLICIT DRUG SUBSTANCES</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/720009592_0bd2b5ee6a.pdf"><strong>Full PDF for download</strong></a></li></ul><div><div><section><div><div><div><div><div><div><p>The poster compares two high-resolution time-of-flight mass spectrometry acquisition strategies for toxicology screening: targeted <strong>Tof-MRM</strong> and data-independent <strong>Tof-MSE</strong>, both implemented on a Waters <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1148"><strong>Xevo MRT MS</strong></a> coupled to an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/199"><strong>ACQUITY UPLC I-Class FTN PLUS System</strong></a>. The aim was to determine whether these approaches could meet routine service requirements for drug testing while also broadening the number of substances that can be detected beyond conventional targeted panels. Urine samples were prepared across a wide concentration range for 20 target analytes, and the methods were also applied to 20 anonymized authentic urine samples.</p><p>Both workflows used a 15-minute LC separation on an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1952"><strong>ACQUITY HSS C18 column</strong></a> under positive electrospray ionization. In the targeted Tof-MRM mode, selected precursor ions were isolated and fragmented, with quantifier and qualifier ions monitored for sensitive quantitative analysis. In contrast, Tof-MSE operated in a data-independent mode, alternating between low and elevated collision energies to collect accurate-mass precursor and fragment-ion information for a broad range of compounds. Data were processed in the waters_connect platform using MS Quan for Tof-MRM and UNIFI with the Waters Toxicology Library, containing more than 2,100 drugs and metabolites, for Tof-MSE.</p><p>The targeted Tof-MRM method provided the highest sensitivity, with limits of detection ranging from <strong>0.05 to 0.5 ng/mL</strong> in fortified urine. The broader Tof-MSE workflow achieved LODs of approximately <strong>0.5 to 5 ng/mL</strong>. When both strategies were applied to authentic urine samples, they showed excellent qualitative agreement. Importantly, Tof-MSE detected additional compounds outside the predefined target panel, including commonly encountered medications, benzodiazepines, antidepressants, and illicit drug substances that would not have been captured by the targeted method alone.</p><p>Overall, the study shows that Tof-MRM can deliver sensitivity comparable to conventional tandem-quadrupole LC-MS/MS for targeted urinary drug analysis, while Tof-MSE adds broader sample characterization and retrospective screening capability. Used together, the two acquisition strategies provide a flexible approach that combines sensitive quantification of predefined analytes with expanded screening for unexpected or previously untargeted drug substances in complex biological samples.</p></div></div></div></div></div></div></section></div></div>

News from LabRulezLCMS Library - Week 39, 2026

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 21st September 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies, LECO </strong>and <strong>Shimadzu</strong> and technical note by <strong>Thermo Fisher Scientific!</strong></p><h3><strong>1. Agilent Technologies: Automated Analysis of Foods by ICP-QQQ with Discrete Sampling and Autodilution</strong></h3><p><strong>Fast, accurate AOAC compliant food analysis using the </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=9500"><strong>Agilent 9500 ICP-QQQ</strong></a><strong> with AVS MS and ADS 2&nbsp;</strong></p><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_automated_food_analysis_9500_icp_qqq_5994_9095en_agilent_e5869385b0.pdf"><strong>Full PDF for download</strong></a><strong>&nbsp;</strong></li></ul><p>Manufacturers and regulatory bodies, including state and federal governments, have an obligation to ensure that food is safe for human consumption. To protect public health, manufacturers and producers follow rigorous testing procedures, such as AOAC Official Method 2015.01 for the analysis of heavy metals in foods using ICP-MS.1 In recent years, global initiatives have sought to strengthen existing regulations and further reduce contaminant limits, as shown by the US Food and Drug Administration’s Closer to Zero program. Meeting these increasingly stringent targets depends on analytical instruments capable of delivering higher performance, improved sensitivity, and greater accuracy. At the same time, food testing laboratories are actively pursuing greater productivity and workflow efficiency to keep pace with evolving analytical demands.</p><p>To support these goals, the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=9500"><strong>Agilent 9500 Triple Quadrupole ICP-MS</strong></a> (ICP-QQQ) and Advanced Dilution System (ADS 2) combine seamlessly to streamline methods, improve productivity, and deliver high-quality results. Using the 9500 instrument’s unique Dual-Cell System (DCS) with Advanced Helium Mode (AHM) and Air cell mode enables effective removal of polyatomic and doubly charged interferences and enhances low-mass sensitivity.2,3 In addition, the ADS 2 simplifies sample preparation by creating calibration standards from a stock solution, pre-diluting samples before analysis, and reactively diluting any samples that exceed the calibration range. Together, these technologies support faster, more reliable delivery of accurate results.&nbsp;</p><p>In this study, various standard reference materials (SRMs) were selected to represent different sample types that may be analyzed in food testing laboratories and to validate the method. As these laboratories often require high productivity, the 9500 ICP-QQQ configuration and analytical method were optimized to maximize sample throughput. The performance of the method was evaluated according to criteria set out in the AOAC 2015.01 method.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>The Agilent 9500 ICP-QQQ with Dual-Cell System (DCS) successfully quantified a broad range of metals in diverse food matrices in accordance with an AOAC standard method. Most elements were measured in AHM, while As and Se were accurately determined at trace levels in Air cell mode using ambient air to eliminate severe doubly charged REE interferences. AHM mode effectively suppressed polyatomic interferences such as NaAr on Cu, even in samples such as NIST 1573a Tomato Leaves, where Na is present at more than 20 times the concentration of Cu.&nbsp;</p><p>Together, the two DCS gas modes provided comprehensive interference control for routine food analysis, as demonstrated by recoveries of certified elements within ±25% for the food SRMs.&nbsp;</p><p>Compared to single-quadrupole ICP-MS, DCS operation in both modes reduced analysis time by about 30 seconds per sample. Automation using the Agilent AVS MS discrete sampling accessory, SPS 4 autosampler, and ADS 2 autodilutor further improved productivity and delivered reliable results, including:&nbsp;</p><ul><li>Detection limits for As, Cd, Pb, and Hg well below the LOQs reported in AOAC 2015.01&nbsp;</li><li>Effective removal of REE2+ interferences on As and Se&nbsp;</li><li>Over 98% Lu recoveries across all SRMs, demonstrating excellent preservation of volatile elements throughout the analysis&nbsp;</li><li>Stable operation over five hours, maintaining CCV and ISTD recoveries within AOAC limits&nbsp;</li></ul><p>The 9500 ICP-QQQ enables high-throughput, AOAC-compliant food analysis by controlling interferences with AHM and Air cell mode, ideal for labs that need speed, reliability, and accuracy.</p><h3><strong>2. LECO: Determination of Total Carbon (TC) and Total Organic Carbon (TOC) in Soil by Acid Digestion and Combustion</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/832_TC_TOC_SOIL_ACID_DIGESTION_COMBUSTION_203_821_679_e5b4978a69.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Total organic carbon (TOC) determination in soil is a widely used method for evaluating soil quality in agriculture. TOC levels are a key indicator of soil vitality, fertility, and capacity for atmospheric carbon sequestration. TOC represents the carbon stored in soil organic matter, which plays a vital role in supporting microbial life, enhancing nutrient availability, and improving soil structure. These benefits translate directly into better water retention, reduced erosion, and more resilient crops—key factors for regenerative systems focused on ecosystem restoration and productivity. TOC levels can also be used to monitor the effectiveness of sustainable practices like crop rotation, cover cropping, reduced tillage, and the addition of organic matter such as manure and compost. Measuring soil TOC levels helps growers optimize the use of soil amendments like compost and manure to increase organic matter without over-application.</p><h4><strong>Instrument Model and Configuration&nbsp;</strong></h4><p>The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1883"><strong>LECO C832</strong></a> is a carbon determinator that utilizes hightemperature combustion in a whole oxygen environment to analyze a wide range of sample types. It features a ceramic combustion furnace in a horizontal orientation designed to analyze macro sample masses. Analysis begins when a sample is weighed into a ceramic combustion boat and inserted into the furnace where combustion is initiated under a controlled flow of oxygen. After a preset time, additional oxygen is applied directly above the sample using a ceramic lance to accelerate and complete the combustion process. The gases are swept from the furnace and passed through anhydrone for the removal of moisture and are then carried to a nondispersive infrared (NDIR) cell for detection of carbon as CO<sub>2</sub>.</p><h4><strong>Typical Results&nbsp;</strong></h4><p>For soils containing up to 5 % carbon, a linear, force through origin calibration using LECO synthetic carbon reference materials is recommended. For soils containing more than 5 % carbon, a linear, full regression calibration using LECO synthetic carbon and calcium carbonate reference materials is recommended.</p><h3><strong>3. Shimadzu: Determination of More Than 25 Nutritional, Essential and Toxic Elements in Whole Blood by ICP-MS Using Alkaline Dilution</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_05_sca_116_014_en_5fc2b521ce.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User Benefits</strong></h5><ul><li>Offering gas switching times &lt;5 sec and ProActive Rinsing function, short sample cycle times can be achieved&nbsp;</li><li>Using whole blood calibrators and control samples in research labs simplifies working routines&nbsp;</li><li>Alkaline media drastically improves washout capabilities for mercury and ensures proper sample stabilization compared to acidic media</li></ul><p>Inductively coupled plasma mass spectrometry (ICP-MS) like <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=1&amp;search=2050"><strong>Shimadzu ICPMS-2050</strong></a> offers ultra-low detection limits and fast multi-element capability required for reliable high throughput measurement of nutritional, essential, and toxic elementsin various complex biological samples.&nbsp;</p><p>While urine has been widely used to monitor elemental excretion, blood serum represents the protein-free fraction of circulating blood. Whole blood, however, contains both cellular and extracellular components, enabling a more integrated assessment of an individual’s nutritional status and exposure to potentially toxic metals than either urine or serum alone. Accordingly, whole-blood ICP-MS analysis is well suited for research applications such as nutritional assessment, toxicology, and biomonitoring studies.</p><h4><strong>Conclusion</strong></h4><p>The ICPMS-2050 LF was specifically configured for robust small volume analysis while reducing carry over, sample cycle times and environmental contamination impacts while being capable of successfully addressing several kind of possibly interference providing most accurate and reliable results.&nbsp;</p><p>The collision- and reaction cell performs efficiently with flowrates of helium and hydrogen in low levels of 6-7mL/min. At the same time, the method uses the well established Minitorch plasma system, allowing lowest argon consumption while reducing power consumption, which makes it exceptionally cost-effective without compromising performance characteristics.&nbsp;</p><p>LabSolutions ICPMS software allows to easily control the device, consumable lifetime, QC-recoveries and internal standard stability. Furthermore, features like ProActive Rinsing and Extended Rinsing speed up the method while reducing carryover risks.</p><h3><strong>4. Thermo Fisher Scientific: User-defined calibrations with Niton XL5 Plus user mode</strong></h3><ul><li>Technical note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/user_defined_calibrations_with_niton_xl5_plus_user_mode_tn1732_en_fc054105e5.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1992"><strong>Thermo Scientific™ Niton™ XL5 Plus Handheld XRF Analyzer</strong></a><strong> </strong>(shown in Figure 1) features a software function called User Mode, designed for experienced users who need to create their own calibrations.</p><p>User Mode has been developed to provide maximum flexibility for performing empirical calibrations. It allows the user to specify certain parameters and to proceed with analytical method development:&nbsp;</p><ul><li>Define and select optimal beam conditions, including filter material and voltage*, while the current is dynamically adjusted to the maximum value.&nbsp;</li><li>Select elements and regions of interest from Na to U.&nbsp;</li><li>Select up to 12 background regions to perform background correction, background subtraction, or Compton normalization.&nbsp;</li><li>Select units of measurement for bulk concentrations, coat weight, and coating thickness.&nbsp;</li><li>Acquire normalized count rates for all selected regions of interest.&nbsp;</li><li>Construct calibration curves and apply mathematical fitting (Figure 2).&nbsp;</li><li>Manually enter calibration model equations for selected analytes as a function of element and background region intensities.&nbsp;</li><li>Validate the calibration model.&nbsp;</li><li>Analyze unknown samples.</li></ul>

News from LabRulezICPMS Library - Week 39, 2026

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Wasson GC O-FID Oxygenated Components in Gasoline Analyzer

Using an Agilent Technologies 8890 with custom Wasson-ECE hardware, this instrument rapidly determines oxygenate components in motor fuels.

<p><strong>Approved for determining oxygenates in gasoline and other motor fuels by ASTM D5599 and EN 1601</strong></p>
<p><strong>The determination of oxygenates in motor fuels</strong> is an important mandate of <strong>the reformulated fuels</strong> program. To meet this goal, the United States Environmental Protection Agency approved the use of <strong>Oxygenate Flame Ionization Detector (O-FID)</strong> analysis in preference to other analyses currently used by the fuels industry.</p>
<h5><strong>Oxygen Selectivity</strong></h5>
<p>Using an <strong>Agilent Technologies 8890 GC</strong> with <strong>custom Wasson-ECE hardware</strong>, this instrument rapidly <strong>determines oxygenate components in motor fuels</strong>. A single injection is introduced onto a capillary column which separates oxygenate components in boiling point order. <strong>A cracking reactor converts hydrocarbons into elemental carbon</strong>, and <strong>oxygenated compounds into carbon monoxide</strong>. A methanizer then further converts the carbon monoxide into methane before eluting to the FID detector.</p>
<p><strong>Because hydrocarbons never make it to the detector, this method completely eliminates problems with hydrocarbon interferences.</strong></p>
<h5><strong>Single GC 8890 Instrument Configurations:</strong></h5>
<ul>
<li><p><strong>ASTM D5599 or EN1601</strong> - Oxygenates in gasoline and other motor fuels by O-FID.</p>
</li>
<li><p><strong>O-FID with D3606</strong> - Oxygenates by O-FID per ASTM D5599 and benzene and toluene in motor fuels by FID per ASTM D3606</p>
</li>
<li><p><strong>O-FID with D4815</strong> - Oxygenates by O-FID per ASTM D5599 and oxygenates by FID per ASTM D4815</p>
</li>
<li><p><strong>O-FID with D4815 and D3606</strong> - Oxygenates by O-FID per ASTM D5599, oxygenates by FID per D4815, and benzene and toluene by FID per ASTM D3606</p>
</li>
</ul>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Altium_International_Wasson_O_FID_GC_analyzator_kyslikatych_latek_Ukazkovy_chromatogram_z_O_FI_Du_32e439263e.jpg" alt="Wasson: Example chromatogram from O-FID GC system"/></p>
<h5><strong>Simple to Use and Operate</strong></h5>
<p>The Wasson-ECE O-FID has been engineered to provide <strong>long life</strong> and <strong>require infrequent service</strong>. When replacement of the cracking reactor or methanizer is necessary, the task can be accomplished in under one hour, including instrument equilibration time.</p>
<h5><strong>Precise Analyses</strong></h5>
<p>Repeatibility tests yield relative standard deviations (RSD) of approximately 1% by weight over a series of 10 runs for all major oxygenated components. The O-FID response is <strong>linear over four orders of magnitude</strong>. An automated injection device is recommended to provide the most reliable means of repeatable injection.</p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Altium_International_Wasson_O_FID_GC_analyzator_kyslikatych_latek_Opakovatelnost_mereni_51c93d3988.jpg" alt="Wasson: GC O-FID Oxygenated Components in Gasoline Analyzer - Repeatibility tests"/></p>


Wasson-ECE GC RGA Refinery Gas Analyzers

Wasson-ECE Refinery Gas Analyzers (RGA) are an integral part of any HPI lab. 

<p><strong>Wasson-ECE Refinery Gas Analyzers (RGA) are an integral part of any HPI lab. These instruments often carry the heaviest sample loads because of the critical information they provide. RGAs provide valuable information regarding plant operation, unit optimization, and quality control. Our RGA systems are designed for flexibility while maintaining the accurate and repeatable results our clients have come to expect.</strong></p>
<p>As a premier <strong>channel partner of Agilent Technologies</strong>, Wasson-ECE extends the capabilities of the <strong>8890 Gas Chromatograph</strong> to meet key requirements of <strong>refinery gas analysis</strong>. The Wasson-ECE RGA incorporates our specially designed auxiliary oven, which holds <strong>up to five additional rotary valves</strong> and <strong>six columns</strong>, extending the analysis capabilities far beyond traditional methods.</p>
<p>At Wasson-ECE we strive to produce a product that is innovative and state-of-the-art to help our customers overcome their analytical challenges. <strong>The flexibility of our RGA systems can ease bench space issues by combining analyses into a single instrument</strong> while maintaining an easy to service system with minimal downtime.</p>
<h3><strong>RGA Features</strong></h3>
<ul>
<li><p><strong>Complete range of analyzers</strong> for refinery and other petroleum gases and liquids</p>
</li>
<li><p>vIncludes method development, selection of valves, and columns** in all configurations</p>
</li>
<li><p><strong>Dual TCDs and a single FID</strong> for the simultaneous analysis of fixed gases and hydrocarbons</p>
</li>
<li><p><strong>Wasson-ECE Auxiliary Oven</strong> which provides a second thermal zone</p>
</li>
<li><p><strong>Customized reports</strong> including calculations for mole %, weight %, or volume %, and calorific value available</p>
</li>
<li><p><strong>Optional liquid sampling valves or On-board Vaporizer</strong> expands the analytical capabilities to liquefied gases</p>
</li>
<li><p><strong>Optional fourth detector</strong> available on all Super RGA configurations</p>
</li>
</ul>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Altium_International_Wasson_RGA_GC_analyzator_rafinerskych_plynu_Wasson_ECE_Moznosti_konfigurace_RGA_17545e3d4c.jpg" alt="Wasson: Wasson-ECE RGA Configuration Options"/></p>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Altium_International_Wasson_RGA_GC_analyzator_rafinerskych_plynu_Ukazkovy_chromatogram_standardni_RGA_1b72a88528.jpg" alt="Wasson: 383-Standard Refinery Gas Analysis"/></p>
<h3><strong>Wasson-ECE Super RGA</strong></h3>
<p>Wasson-ECE has the unique ability <strong>to add a fourth detector to the GC</strong>, building our Super RGA series of analyzers. The additional detector <strong>expands the analytical capabilities</strong> of the standard RGA to accommodate applications such as <strong>sulfurs</strong>, <strong>oxygenates</strong>, <strong>heavy hydrocarbons</strong>, and <strong>trace CO/CO₂</strong>. This increased flexibility in configurations can reduce the number of GC’s used in a lab, saving clients valuable bench space and time.</p>
<h5><strong>Performance Guarantee</strong></h5>
<p>From hardware to analysis <strong>we stand behind our quoted application</strong>. Prior to shipping the instrument, <strong>chromatograms are submitted for customer approval</strong>. Performance is guaranteed to the clients actual sample, not just a generic standard. Any problems with the application during the first year are covered under warranty for an unparalleled performance guarantee.</p>
<h3><strong>The Wasson-ECE Turn-key Process</strong></h3>
<h5><strong>Sales</strong></h5>
<ul>
<li>Application designed to customer&#39;s requirements</li>
</ul>
<h5><strong>Factory Application</strong></h5>
<ul>
<li>Method development and application setup</li>
<li>Customer samples are run to verify performance</li>
<li>Chromatograms are sent for client approval</li>
<li>Factory acceptance training if desired</li>
</ul>
<h5><strong>Installation</strong></h5>
<ul>
<li>Experienced Wasson Field Service Technician</li>
<li>Analysis of client’s real world samples</li>
<li>Calibration and familiarization</li>
</ul>
<h5><strong>Customer Satisfaction</strong></h5>
<ul>
<li>Follow up after installation</li>
<li>Knowledgeable and responsive service team</li>
<li>Optional preventative maintenance visits or service contracts</li>
</ul>
<p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Altium_International_Wasson_RGA_GC_analyzator_rafinerskych_plynu_Ukazkove_chromatogramy_Super_RGA_c62a4d715e.jpg" alt="Wasson: Example chromatograms (Super RGA)"/></p>


Watrex Streamline GPC system

GPC system is an isocratic HPLC system consisting of one P1 pump, CT1i column thermostat with manual injector and RI1 refractive index detector.

<p><strong>GPC system is an isocratic HPLC system consisting of one P1 pump, CT1i column thermostat with manual injector and RI1 refractive index detector.</strong></p><h3><strong>FEATURES</strong></h3><ul><li>Optimized pump mechanics of P1 pump with parallel piston design offers excellent flow rate accuracy and low RI signal pulsation.</li><li>The thermal isolated optic with a counter-current heat exchanger and programmable temperature control, results in an extremly stable baseline and an optimal Signal/Noise ratio od RI1.</li><li>The system can be upgraded with autosampler and fraction collector, or VD 400 Viscometer Detector.</li><li>Data acquisition, processing and instrument control is done by Clarity Chromatography Station with GPC option or Agilent TriSEC software.</li></ul><h3><strong>TECHNICAL SPECIFICATION</strong></h3><ul><li><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?s=streamline+p1+pump&amp;post_type=product&amp;dgwt_wcas=1?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>P1 HPLC pump: Flow Rates</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/chromatography/detectors/other-hplc-detectors/streamline-ri1-detector/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>RI1 refractive index detector</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/chromatography/column-thermostats/streamline-ct1-columm-thermostat/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>CT1 Column thermostat</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999"><strong>Clarity™ Chromatography Station</strong></a></li></ul><h5><strong>COMPONENT SPECIFICATION - P1 HPLC pump: Flow Rates</strong></h5><ul><li><strong>Flow Rates:</strong> 0.001 to 10.000 mL/min</li><li><strong>Pressure:</strong> 0 to 6,000 psi (42 MPa)</li><li><strong>Flow precision:</strong> &gt; 0.2% RSD</li><li><strong>Flow accuracy:</strong> ± 1 % @ 1mL/min and 7 MPa,</li><li><strong>Pressure accuracy:</strong> ± 2% of full-scale, with 80:20 H2O/IPA @ 7 MPa</li><li><strong>Pulsation:</strong> ± 0.5 % @ 1mL/min and 7 MPa</li><li><strong>Remote inputs:</strong> USB</li></ul><h5><strong>COMPONENT SPECIFICATION - RI1 refractive index detector</strong></h5><ul><li><strong>Light Source:</strong> Long-life LED</li><li><strong>Refractive index Range:</strong> 1.00 - 1.75 RIU</li><li><strong>Baseline Noise:</strong> ± 2.5 nRIU</li><li><strong>Baseline Drift:</strong> 200 nRIU/h</li><li><strong>Linearity:</strong> &gt; 1000 μRIU</li><li><strong>Flow cell pressure resistance:</strong> 5 bar</li><li><strong>Flow cell volume:</strong> 15 μl</li><li><strong>Time constant:</strong> 0.00/0.01/0.02/0.05/0.1/0.2/0.5/1.0/2.0/5.0/10.0 s</li><li><strong>Analog Output:</strong> 1x 0-2.5V</li><li><strong>Outputs:</strong> Event 1, Start (OUT), Error (OUT), + 5 V, 24 V Valve</li></ul><h5><strong>COMPONENT SPECIFICATIONS - CT1 Column thermostat</strong></h5><ul><li><strong>Temperature range:</strong> 10 °C above ambient temperature to 100 °C</li><li><strong>Temperature accuracy:</strong> max. 0,5 % of actual temperature</li><li><strong>Temperature stability:</strong> RSD &lt; 0,4 %</li><li><strong>Settability:</strong> 0,1 °C</li><li><strong>Internal dimensions:</strong> 320 x 50 x 30 mm (L x W x H)</li><li><strong>Compartment material:</strong> PTFE coated metal</li><li><strong>Compartment connection:</strong> USB</li><li><strong>Control:</strong> build-in color touch panel, datasystem</li></ul><h5><strong>COMPONENT SPECIFICATIONS - </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/999"><strong>Clarity™ Chromatography Station:</strong></a></h5><p>Advanced chromatographic datastation for data acquisition and evaluation supported with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1004"><strong>GPC module for MWD, Mw, Mn, Mz calculation</strong></a>. Enables rutine separations with pre-set methods, containing all experimental and conditions and data evaluation settings. PC Win 10 Professional with LCD monitor included.</p><h3><strong>Ordering information:</strong></h3><h5><strong>PN/Component:</strong></h5><ul><li><strong>SGPC01-001</strong> Streamline™ manual GPC system with Refractive index detector (Includes P1 pump, RI1 detector, CT1i column thermostat with manual injector, solvent rack, Clarity PC station)</li></ul><p><strong>Optional configurations:</strong></p><ul><li><strong>ST99-002</strong> Remove CT1i column thermostat with manual injector from system</li><li><strong>SAS90-001</strong> Add AS1 Autosampler to system</li><li><strong>SFC90-001</strong> Add FC1 Fraction collector to system</li></ul>

Watrex SCS 205 GPC Sample cleanup system

The Watrex Streamline SCS 205 Sample Clean-up System is designed for GPC sample pretreatment.

<p>Sample clean-up is an <strong>essential method</strong> for many routine chromatography applications. One of the most common cases is analysis of <strong>polyaromatic hydrocarbons</strong> (PAHs), <strong>polychlorinated biphenyls</strong> (PCBs) and <strong>pesticides</strong> in complex mixtures.</p><p>The initial step is an isolation of hydrophobic (lipophilic) components from the rest of the sample mixture by <strong>gel-permeation</strong><br><strong>chromatography</strong> (GPC).</p><p>In such configuration, triglycerides (700-900Da) can be isolated from low molecular (200-300Da) PAHs, PCBs or pesticides using<br>GPC steric exclusion. SCS 205 is a dedicated system for GPC sample pretreatment. SCS 205 includes an isocratic pump double piston pump, manual injector with preparative sample loop, PAH/PCB preparative column (200mg sample loading capacity), fraction collector and start-up kit. .The entire system is controlled from a TFT touch display through intuitive screens.</p><p>After injection and GPC separation, the purified sample (PAHs, PCBs etc.) is captured by an automated fraction collection usinga3-way motorized switching valve. The timing of the collection is predetermined from the elution profile of the pollutants.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Watrex_SCS_205_Sample_cleanup_system_column_7dce4f25e0.jpg" alt="Watrex: Watrex SCS 205 Sample cleanup system - column"></p><h3><strong>FEATURES</strong></h3><ul><li>High performance pollutant izolation from complex matrices</li><li>Eluent flexibility</li><li>Easy programmable</li><li>Easy installation &amp; Simple operation</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Watrex_SCS_205_Sample_cleanup_system_schema_ad45276ad0.jpg" alt="Watrex: Watrex SCS 205 Sample cleanup system - schema"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Watrex_SCS_205_Sample_cleanup_system_graph_10ce455cc3.jpg" alt="Watrex: Watrex SCS 205 Sample cleanup system - graph"></p><h3><strong>TECHNICAL SPECIFICATION</strong></h3><ul><li><strong>Sampling System:</strong> manual valve</li><li><strong>Sample volume:</strong> 2 mL loop</li><li><strong>Fraction collection:</strong> 50mL flask</li><li><strong>Collection time programming:</strong> alternating valve switching to waste/collect/waste</li><li><strong>Display:</strong> 4-character</li></ul><h3><strong>Ordering information:</strong></h3><h5><strong>PN/Component:</strong></h5><ul><li><strong>SCS205-001</strong> SCS 205 Sample Clean-up System (<strong>Price 8 627 € ex VAT</strong>)</li><li><strong>WI02077</strong> WATREX 250x16 mm PAH Prep column, 10 um</li><li><strong>DGD.3008</strong> WATREX 300x8 mm DeltaGel Mixed-D column, 5 um</li><li><strong>DGB.25020</strong> WATREX 250x20 mm DeltaGel Mixed-B column, 5 um</li></ul><p><strong>You can also visit this product on the </strong><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/chromatography/dedicated-instruments/scs-205-sample-clean-up-system/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>Watrex website</strong></a><strong>.</strong></p>

Watrex xTrovert XT Automatic DNA/RNA extractor

Watrex xTrovert XT is an automatic DNA/RNA extractor. It streamlines the extraction process, making it more efficient and reproducible.

<p><strong>Automatic extractor utilises a simple principle of two pipetting heads serving a 96-well plate.</strong></p><p>Thanks to easy replacement head options of pipetting with <strong>300 μl tips</strong> or <strong>1000 μl</strong> tips are available. <strong>Automatic optical sensor calibration</strong> enables the use of pipetting tips and <strong>96-well plates</strong> from virtually any supplier. The device is equipped with two magnetic arms for protocols including paramagnetic SPR beads. It also allows for thermal incubation in the range of <strong>25 to 85 °C</strong>. In addition to internal <strong>LED lighting</strong>, the station is equipped with an integrated <strong>UV-C sterilisation unit</strong>. Intuitive control from <strong>TFT touch panel</strong> user interface facilitates easy set-up. xTrovert™ XT is a <strong>fully programmable open system</strong> where user can create their own workflow scripts downloadable as text files from USB flas disk.</p><h3><strong>APPLICATIONS</strong></h3><ul><li><strong>Sample prep for PCR testing</strong></li><li><strong>NGS library prep</strong></li><li><strong>Sanger DNA sequencing</strong></li></ul><h3><strong>CURRENT PROTOCOLS</strong></h3><ul><li><strong>DNA/RNA extraction</strong></li><li><strong>DNA purification</strong></li><li><strong>PCR clean-up/desalting</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Watrex_x_Trovert_XT_Automatic_DNA_RNA_extractor_Compatible_with_any_magnetic_bead_based_kit_23886eea52.jpg" alt="Watrex: Watrex xTrovert XT Automatic DNA/RNA extractor - Compatible with any magnetic bead based kit"></p><h3><strong>TECHNICAL SPECIFICATION</strong></h3><ul><li><strong>Capacity:</strong> 16 or 32 samples/run</li><li><strong>Volume range:</strong> 10 – 600 μl</li><li><strong>Temperature:</strong> 25 – 85 °C</li><li><strong>Sterilization:</strong> UV-C</li><li><strong>Display:</strong> 3,5“ TFT touch display</li><li><strong>Connectivity:</strong> USB 1.0/2.0</li><li><strong>Power source:</strong> 24 V adaptor</li><li><strong>Dimensions in cm:</strong> 65(w) x 65(h) x 34(d)</li><li><strong>Weight:</strong> 25 kg</li></ul><h3><strong>Ordering information:</strong></h3><h5><strong>PN/Component:</strong></h5><ul><li><strong>XTR000-001</strong> xTrovert™ XT Universal robotic pipettor for DNA/RNA extraction &amp; handling</li><li><strong>XTR000-003</strong> Replaceable 8-channel 1000uL pipetting head for xTrovert™ XT</li><li><strong>XTR000-004</strong> Replaceable 8-channel 300uL pipetting head for xTrovert™ XT</li><li><strong>XTR000-100</strong> Deepwell plates (empty) for xTrovert™ XT</li><li><strong>XTR000-220</strong> DNA/RNA extraction kit, mgn. beads, 16-rxns per plate</li></ul><p>The entire system was designed and developed by Watrex Praha and is <strong>manufactured in the Czech Republic</strong> and promises a shift in the performance and efficiency of laboratory processes worldwide!</p><p><strong>You can also visit this product on the </strong><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/obchod/laboratory-automation/xtrovert-xt/?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>Watrex website</strong></a><strong>.</strong></p>

Watrex SPR-200 Solvent saver

Watrex SPR-200 Solvent Recycler is designed to save up to 90% of mobile phase during isocratic HPLC.

<p>This Solvent Recycler <strong>saves up to 90% of mobile phase</strong> by redirection of the pure solvent to the solvent reservoir during the isocratic HPLC. The stand alone device is powered by 5 V DC from <strong>power adapte</strong>r or from computer <strong>USB port</strong>. Working parameters (<strong>Threshold and Delay</strong>) are easily set on the display using a membrane keyboard.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Watrex_Watrex_SPR_200_Solvent_saver_I_Nputs_694d991f2c.jpg" alt="Watrex: Watrex SPR-200 Solvent saver - INputs"></p><p>The SPR-220™ Solvent Recycler <strong>continuously monitors the output signal</strong> of the chromatography detector and displays its current value on the built-in display. A <strong>highresolution analog-to-digital converter</strong> provides data for further evaluation in the built-in processor. If the input signal level exceeds a preset value (Threshold), the SPR-200 will redirect the flow to the waste.</p><p>When the signal drops, the solvent recycler waits for the transport delay and then switches the mobile phase <strong>back to the reservoir</strong>. An autosampler injection marker connected to the SPR-200 ZERO input can be used to zero the input signal at the time of injection.</p><h3><strong>FEATURES</strong></h3><ul><li>Stand alone operation</li><li>Detachable valve</li><li>Possibility of manual Waste/Recycle switching</li></ul><h3><strong>TECHNICAL SPECIFICATION</strong></h3><ul><li><strong>Detector compatibility:</strong> compatible with any HPLC detector</li><li><strong>Connection:</strong> 1/16″ O.D. tubing, 1/4″-28 flat bottom fittings</li><li><strong>Maximum pressure:</strong> 30 p.s.i./0,2 MPa</li><li><strong>Wetted material:</strong> PEEK, PTFE</li><li><strong>Input range:</strong> +/- 1 V or +/- 100 mV, user selectable</li><li><strong>Computer connection:</strong> μUSB</li><li><strong>TTL/contact closure input:</strong> configurable (ZERO, start, valve position)</li><li><strong>Power:</strong> 5V DC/&lt;100 mA (power supply or computer USB port)</li><li><strong>User interface:</strong> large character LCD alphanumeric display + membrane keypad</li></ul><h3><strong>Ordering information:</strong></h3><h5><strong>PN/Component:</strong></h5><ul><li><strong>SPR200-001</strong> SPR-200 Solvent Recycler, PEEK version (<strong>Price 1 250 € ex VAT</strong>)</li><li><strong>SPR200-002</strong> SPR-200 Solvent Recycler, PTFE version (<strong>Price 1 250 € ex VAT</strong>)</li></ul><p><strong>You can also visit this product on the </strong><a target="_blank" rel="noopener noreferrer" href="https://watrex.com/?s=SPR-200+Solvent&amp;post_type=product&amp;dgwt_wcas=1?utm_source=labrulez&amp;utm_medium=propagace&amp;utm_campaign=labrulez_produkty"><strong>Watrex website</strong></a><strong>.</strong></p>

Waters Xevo MRT QTof Mass Spectrometer

Achieve exceptional science with the Xevo™ MRT Mass Spectrometer—100K resolution at 100 Hz, sub-ppm accuracy, and confident identification for greater lab productivity.

<h3><strong>Delivering Performance and SPEED</strong></h3><ul><li><strong>Resolution AND Speed Without Compromise</strong></li></ul><p><strong>Whether you’re in academia or industry achieve exceptional science - 100% of the time with the Xevo™ MRT Mass Spectrometer. This state-of-the art QTof delivers 100K resolution at 100 Hz with sub ppm mass accuracy for confident identification and greater productivity in your lab.</strong></p><h4><strong>Delivering performance at speed</strong></h4><p>The high resolution and mass accuracy of the Xevo MRT Mass Spectrometer are independent of acquisition rate. Working at maximum resolution ensures you can resolve analytes in complex matrices, providing comprehensive, high accurate mass data for scientific interpretation.</p><h4><strong>Increase compound identification confidence</strong></h4><p>Probe deeper at biologically relevant concentrations with high levels of mass accuracy. Search tolerances can be minimized resulting in efficient data review, improving turnaround times for increased lab productivity.</p><h4><strong>Connected solutions</strong></h4><p>A complete workflow for metabolomics, lipidomics, and metabolite identification through market leading chemistry and cutting-edge, informatics ensures your lab is operating with maximum efficiency – reducing the time to result.</p><h4><strong>Exceptional science - every day</strong></h4><p>System performance is critical. From instrument stability and robustness for extended studies to precision measurements in every injection, innovative multi reflecting time-of-flight technology delivers high quality experimental outcomes for every lab, every day.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_MRT_Hmotnostni_spektrometr_1_63e746d310.jpg" alt="Waters Xevo MRT Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_MRT_Hmotnostni_spektrometr_1_63e746d310.jpg 244w," sizes="100vw" width="1119" height="715"></p><h3><strong>Extraordinary Performance</strong></h3><h4><strong>Without compromises</strong></h4><h5><strong>Exceptional science for every lab, scientist, problem, question, and sample… Solved</strong></h5><p>The exceptional combination of high mass resolving power of 100,000 FWHM and mass accuracy of &lt;500 part per billion (ppb) of the Xevo MRT Mass Spectrometer are achieved independent of acquisition rates, up to 100Hz. Maximum performance, matched to throughput levels that matter for complex and challenging analyses, increases statistical power and confidence in results.</p><h5><strong>Feeling trapped?</strong></h5><p>Unlike other high-resolution MS technologies, multi-reflecting time-of-flight delivers mass resolution consistent over a broad m/z range independent of scan speed, even at the fastest acquisition rates for MS and MS/MS data, ensuring confident identification of analytes across a range of samples and matrices – an ideal solution for metabolite profiling and discovery.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_MRT_Mass_Spectrometer_Extraordinary_Performance_d8879eda23.jpg" alt="Waters Xevo MRT Mass Spectrometer: Extraordinary Performance." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_MRT_Mass_Spectrometer_Extraordinary_Performance_d8879eda23.jpg 245w," sizes="100vw" width="1309" height="774"></p><h3><strong>Connected Solutions</strong></h3><h4><strong>From advanced chemistry to flexible informatics</strong></h4><p>Make meaningful scientific discoveries more efficient with dedicated workflows combining column chemistries, separations, and informatics with the exceptional data quality of the Xevo MRT Mass Spectrometer. The waters_connect™ platform allows you to process and report your data in the way that you want. Whether using a Waters supported solution or exporting data via mzML to custom scripted workflows, we have you covered.</p><h4><strong>The Xevo MRT mass spectrometer readily integrates with your existing pipeline and workflow strategy</strong></h4><p>Waters has partnered with Mass Analytica™ (mass-analytica.com) and their market leading metabolomic, lipidomic, and metabolite identification software packages, MARS, Lipostar2, and MassMetaSite, respectively. Through either the waters_connect Application Programming Interface (API) or via mzML*, there is the option for you to transfer your data into the relevant software package for statistical interpretation and identification of analytes.</p><p>The DATA Convert Application within the waters_connect Platform enables you to convert to and export mzML file formats, ensuring a seamless integration of technology and informatics for every lab.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_MRT_Hmotnostni_spektrometr_6_d0fc257136.jpg" alt="Waters Xevo MRT Mass Spectrometer: Connected Solutions." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_MRT_Hmotnostni_spektrometr_6_d0fc257136.jpg 236w," sizes="100vw" width="1212" height="802"></p><p>The waters_connect platform provides flexible data processing options, either using third-party applications via the waters_connect API or conversion of data sets to mzML file format via DATA Convert.&nbsp;</p><h3><strong>Unlocking a New Level of Confidence&nbsp;</strong></h3><h4><strong>By bringing an analytical powerhouse to every lab</strong>&nbsp;</h4><p>To meet the most challenging analytical problems that you experience head on, Waters has taken cutting edge technology that was pioneered in the SELECT SERIES™ MRT, scaling the raw power and resolution at speed into a compact flexible, benchtop platform.</p><h4><strong>The MRT Xevolution</strong></h4><p>The Xevo MRT Mass Spectrometer has been engineered to deliver high-end technology into a benchtop platform to solve your most challenging problems. The novel acquisition system, with dual gain analogue-to-digital converter, delivers long term system stability over a high dynamic range, ensuring exceptional quality data with consistent robustness and reproducibility.</p><p>The 4 m flight path with a total of 8 reflections within the MRT mass analyzer, achieves 100,000 FWHM resolution at scan rates of up to 100 Hz - for ultimate MS/MS performance.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_MRT_Hmotnostni_spektrometr_Schema_2448b0bc8d.jpg" alt="Waters Xevo MRT Mass Spectrometer: The Xevo MRT Mass Spectrometer schematic. ​" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_MRT_Hmotnostni_spektrometr_Schema_2448b0bc8d.jpg 236w," sizes="100vw" width="1199" height="794"></p>

Thermo Scientific Stellar Mass Spectrometer

Move biomarker candidates from discovery to validation more efficiently, confidently, and at lower cost with breakthroughs in extended scale, massive throughput, higher sensitivity, greater specificity, and unrivaled productivity.

<div><div id="container-a1c36dfacf"><div><div><div id="text-913638046"><p><strong>A new paradigm for targeted quantitation.&nbsp;Move biomarker candidates from discovery to validation more efficiently, confidently, and at lower cost with breakthroughs in extended scale, massive throughput, higher sensitivity, greater specificity, and unrivaled productivity.</strong></p><p>The Thermo Scientific Stellar Mass Spectrometer introduces revolutionary technology combining robust quantitation with the specificity of rapid full scan MS<sup>n</sup>&nbsp;acquisition creating unrivaled improvements in laboratory productivity.</p><div><div id="text-801893275"><h3><strong>Expanded experimental capabilities to meet the most challenging biomarker verification</strong></h3></div></div><div><div id="container-1e8e478f3a"><div><div><div id="text-1204752335"><p>The Thermo Scientific Stellar Mass Spectrometer offers an array of data acquisition capabilities to deliver robust and reproducible quantitation for a wide range of analytes across an extended dynamic range.</p></div></div></div></div></div><h4><strong>System highlights</strong></h4><div><div id="container-a89a56f063"><div><div><div id="text-451891225"><h5><strong>Improve ionization efficiency for more compounds at higher LC flow rates&nbsp;</strong></h5></div></div><div><div id="text-1671602085"><p>For a wider range of compounds separated using liquid chromatography operated at analytical flow rates, the Stellar Mass Spectrometer comes equipped with the Thermo Scientific OptaMax Plus Ion Source, which can deliver higher vaporizer temperatures to improve desolvation and ionization potentials.</p></div></div></div></div></div><figure class="image"><img style="aspect-ratio:1290/725;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_Stellar_revolucni_hmotnostni_spektrometr_SF_Sys_Opta_Max_c303cf500a.jpg" alt="Thermo Fisher Scientific: Thermo Scientific Stellar Mass Spectrometer - SF Sys OptaMax" width="1290" height="725"></figure><div><div id="container-d79c3b2946"><div><div><div id="text-251514658"><h5><strong>Spend less time on instrument set-up and focus on the science</strong></h5></div></div><div><div id="text-989104128"><p>Trigger on-demand or scheduled system calibrations remotely and without disruption to your LC-MS system with the integrated Auto-Ready ion source.</p></div></div></div></div></div><div><div id="container-81dd07c9bb"><div><div><div id="text-1289282711"><h5><strong>Improve ion utilization by extending the capabilities of the new collision cell</strong></h5></div></div><div><div id="text-1641484825"><p>The ion concentrating routing multipole (ICRM) is a curved collision cell performing both beam-type fragmentation (HCD) and precursor/product ion accumulation capabilities as controlled by dynamic automatic gain control (AGC) with synchronized ion packet release to the high-pressure linear ion trap for downstream manipulation or detection.</p></div></div></div></div></div><figure class="image"><img style="aspect-ratio:1290/725;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_Stellar_revolucni_hmotnostni_spektrometr_SF_Sys_ICRM_3b2326f3af.jpg" alt="Thermo Fisher Scientific: Thermo Scientific Stellar Mass Spectrometer - SF Sys ICRM" width="1290" height="725"></figure><div><div id="container-dbf5a6cdd9"><div><div><div id="text-813962034"><h5><strong>Efficiently manage ion populations for fast and sensitive analysis</strong></h5></div></div><div><div id="text-2033771024"><p>The&nbsp;hyper-fast dual-pressure linear ion trap mass analyzer expands analytical capabilities while maximizing fast, high-quality data acquisition.</p><p>The differential neutral pressures maintained in the high- and low-pressure linear ion traps prepares ions for higher-order manipulation or fast and sensitive ion ejection at scan rates up to 220 kDa/S, but typically operates at 125 kDa/S for robust data acquisition.</p></div></div></div></div></div><div><div id="container-9a523f34e0"><div><div><div id="text-1491120095"><h5><strong>Extended analytical capabilities to increase laboratory productivity</strong></h5></div></div><div><div id="text-328051555"><p>The high-pressure linear ion trap maximizes ion packet manipulation enabling multi-notch RF excitation for dissociation or ejection for SIM, higher order MS<sup>n</sup>, SPS MS<sup>3</sup>, or data-independent acquisition (DIA) to address the most challenging quantitative experiments.&nbsp;</p><div><div id="container-82e5907416"><div><div><div id="text-693866740"><h5><strong>Leverage single ion detection sensitivity to address the most challenging quantitation demands</strong></h5></div></div><div><div id="text-737565098"><p>Efficient and sensitive ion detection drives improved quantitative performance at scale. The dual conversion dynode configuration coupled to the photomultiplier tube detects ca. 84% of trapped ions for single ion sensitivity.</p></div></div></div></div></div></div></div></div></div></div><figure class="image"><img style="aspect-ratio:2048/1152;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_Stellar_hmotnostni_spektrometr_SF_Sys_Extended_Scale_750dc20128.jpg" alt="Thermo Fisher Scientific: Thermo Scientific Stellar Mass Spectrometer - SF Sys Extended Scale" width="2048" height="1152"></figure><div><div id="text-1993749933"><h5><strong>Automated intelligence manages tMSn acquisition</strong></h5></div></div><div><div id="text-1206797739"><p>Streamline tMSn method creation and data acquisition management. PRM Conductor software effectively and efficiently creates robust targeted quantitative methods and manages reproducible data acquisition and processing.</p></div></div><div><div id="container-b03b606507"><div><div><div id="text-2005266584"><h5><strong>Maximize data completeness with the Adaptive RT routine</strong></h5></div></div><div><div id="text-671832198"><p>Eliminate the cost and time of optimizing RT kits to the study samples to boost timed/scheduled data acquisition performance using the Adaptive RT routine.</p><p>The method leverages a novel real-time mapping routine to dynamically adjust timed/scheduled data acquisition windows at narrower time intervals to eliminate missing values that compromise data quality.&nbsp;</p></div></div></div></div></div><figure class="image"><img style="aspect-ratio:1290/654;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_Stellar_revolucni_hmotnostni_spektrometr_SF_Sys_PRM_Conductor_5b596e7e4c.jpg" alt="Thermo Fisher Scientific: Thermo Scientific Stellar Mass Spectrometer - SF Sys PRM Conductor" width="1290" height="654"></figure><div><div id="container-a192ba4b83"><div><div><div id="container-38d4c699d2"><div><div><div id="text-1578189934"><h5><strong>Industry-leading polarity switching speeds increase laboratory productivity</strong></h5></div></div><div><div id="text-1173595596"><p>Reduce the time, cost, and challenges associated with creating and implementing highly multiplexed quantitative metabolite analysis. Fast polarity switching speeds enable comprehensive compound interrogation in +ESI and -ESI at all MS<sup>n</sup> levels on an LC timescale.</p><div><div id="container-b5fb525888"><div><div><div id="text-18006314"><h5><strong>Environmentally friendly dry pumps decrease energy usage and maintenance</strong></h5></div></div><div><div id="text-1704557304"><p>Changing from two oil-based fore pumps to a single dry pump reduces heat output by 22% and decreases maintenance.</p><p>The use of a single dry pump also eliminates oil vapors and the need for oil checks and changes.</p><h3><strong>Solutions for additional research support</strong></h3><div><h4><strong>Translational proteomics</strong></h4><p>The Stellar Mass Spectrometer offers new possibilities for translational proteomics with improved specificity for greater quantitative performance at scale.</p><h4><strong>Quantitative proteomics</strong></h4><p>Accurate and precise quantitation for label-free and TMT multiplexing sample analysis strategies with the Stellar Mass Spectrometer.</p><div><h4><strong>Metabolomics and Lipidomics</strong></h4><p>Extended analytical capabilities quantify more metabolites and lipids with greater specificity using faster liquid chromatography gradients to increase laboratory productivity.</p></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Modern HPLC separations in theory and practice

This book is a unique combination of theory and practice, but also overviews of stationary phases, sample prep materials, and vendor’s brief presentations.

Galochrom Chiral ION-QD HPLC columns

These HPLC columns are based on high-quality spherical silica from the world's leading silica manufacturer from Japan.

<p><strong>Chiral ion exchanger GEN-QD is highly efficient in the enantiomer resolution of acidic compounds.</strong></p><p>This product is now available in high quality and at a reasonable price at our company!</p><p>To create our <strong>chiral sorbent</strong>, we use <strong>3µm fully porous spherical silica particles</strong>, which provide greater efficiency than the original product.</p><p>Additionally, our <strong>Galo-ION-QD-200</strong> is recommended for <strong>biological applications</strong> due to its larger pore size, which improves the separation efficiency for large molecules.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Galochrom_Galochrom_Chiral_ION_QD_HPLC_kolony_ION_QD_selector_10dd9c7ee5.jpg" alt="Galochrom: Galochrom Chiral ION-QD selector."></p><h5><strong>Premium Quality</strong></h5><p>In every manufactured product, we guarantee the highest standards of quality.</p><h5><strong>Cost-effective</strong></h5><p>Our unique products optimize your budget &amp; enhance efficiency in your laboratory operations.</p><h5><strong>High-performance</strong></h5><p>Besides their outstanding performance, our HPLC columns also expand your separation possibilities.</p><h3><strong>Ordering information</strong></h3><blockquote><p><strong>Stationary phase Chiral ION-QD is provided in these column types: analytical and preparative</strong></p></blockquote><h4><strong>Analytical Columns</strong></h4><ul><li><strong>Dimensions [mm]: 150 x 3</strong></li><li>Porosity: [Å] 200</li><li>Cat. No.: ION02-A150</li><li><strong>Price [€]: 1 300</strong></li></ul><blockquote><h4><strong>Get up to a 20% discount on your first purchase with us.</strong></h4></blockquote><h3><strong>Reach new heights</strong></h3><p>Spend more time on testing and less time on troubleshooting</p><blockquote><h4><strong>How can our unique columns help you succeed?</strong></h4><p>Chiral ION-QN and Chiral ION-QD empower researchers with their daily tasks, such as:</p><ul><li>Seamless method development</li><li>Enantioseparation</li><li>Quality control</li><li>Monitoring of asymmetric reactions</li><li>Intermolecular interaction studies</li><li>Pharmacokinetic studies</li><li>Preparative separation</li><li>Production scale-up</li><li>Efficient purification</li></ul></blockquote><h4><strong>What makes Chiral </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1241"><strong>ION-QN</strong></a><strong> and ION-QD unique?</strong></h4><p><span style="font-size:20px;"><strong>Designed for stability</strong></span></p><p>The manufacturing of Chiral ION-QN and Chiral ION-QD was designed to produce highly reproducible and reliable HPLC columns. Our high standards in synthesis of organic selectors and robust packing technology ensures that each customer receives identical high-performance product.</p><p><strong>The chromatographic results are reproducible from run-to-run, column-to-column and batch-to-batch.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Galochrom_Chiral_ION_QN_and_Chiral_ION_QD_HPLC_columns_Designed_for_stability_1_9dea7516f4.jpg" alt="Galochrom: Chiral ION-QN &amp; Chiral ION-QD HPLC columns - Designed for stability." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Galochrom_Chiral_ION_QN_and_Chiral_ION_QD_HPLC_columns_Designed_for_stability_1_9dea7516f4.jpg 245w," sizes="100vw" width="655" height="376"></p><p>During our manufacturing, we implement strict quality control measures over all aspects from silica chemistry up to column packing. As a result, almost no variation is observed among manufactured batches of chiral stationary phases.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Galochrom_Chiral_ION_QN_and_Chiral_ION_QD_HPLC_columns_Designed_for_stability_2_50c42d67e6.jpg" alt="Galochrom: Chiral ION-QN &amp; Chiral ION-QD HPLC columns - Designed for stability." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Galochrom_Chiral_ION_QN_and_Chiral_ION_QD_HPLC_columns_Designed_for_stability_2_50c42d67e6.jpg 245w," sizes="100vw" width="1176" height="442"></p><h3><strong>Achieve your results</strong></h3><p>Increase your productivity with uniform, stable, and reproducible results</p><h4><strong>High-Quality Silica</strong></h4><p>Our columns contain fully-porous spherical particles from world’s leading manufacturer based in Japan. These ultra-pure silica particles have narrow size distribution to ensure reproducible, robust and reliable results.</p><p>In comparison to other manufacturers, Galochrom’s custom packing technology produces very stable and uniform bed with intact silica particles. As a<br>result, our columns:</p><ul><li>Enhance productivity and resolution</li><li>Provide accurate and consistent performance</li><li>Generate significantly higher plate counts</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Galochrom_Chiral_ION_QN_and_Chiral_ION_QD_HPLC_columns_High_Quality_Silica_522d14ecf7.jpg" alt="Galochrom: Chiral ION-QN &amp; Chiral ION-QD HPLC columns - High-Quality Silica." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Galochrom_Chiral_ION_QN_and_Chiral_ION_QD_HPLC_columns_High_Quality_Silica_522d14ecf7.jpg 245w," sizes="100vw" width="617" height="386"></p><h4><strong>Elution Order</strong></h4><p>Chiral ION-QN and Chiral ION-QD represent a pair of columns that enable the reversal of elution order of enantiomers.<strong> Now you can position your desired enantiomer first and easily achieve 100% purity at higher pace.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Galochrom_Chiral_ION_QN_and_Chiral_ION_QD_HPLC_columns_Elution_Order_85c5b02411.jpg" alt="Galochrom: Chiral ION-QN &amp; Chiral ION-QD HPLC columns - Elution Order." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Galochrom_Chiral_ION_QN_and_Chiral_ION_QD_HPLC_columns_Elution_Order_85c5b02411.jpg 245w," sizes="100vw" width="953" height="545"></p><p>The elution order was investigated with other QN/QD derivatives using enantiomeric pairs of Leucine derivatives. The conclusions for the first eluent are following:</p><ul><li>Chiral ION-QN ⇒ L-Enantiomer</li><li>Chiral ION-QD ⇒ D-Enantiomer</li></ul>

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