ISC 2026 - Day 2

<h4><strong>What if you could compress 179 days of grueling laboratory workflow into just 14 hours?</strong></h4><p><strong>In this episode of ‪ChromatographyTalk‬, ‪Organomation‬ General Manager David Oliva sits down with analytical chemist Laura Penabad to discuss her groundbreaking new research in biocatalysis and high-throughput screening. Evolving engineered enzymes typically requires checking thousands of variants—a massive bottleneck when traditional Liquid Chromatography-Mass Spectrometry (LC-MS) runs take minutes per sample. Laura reveals how her team built a modular screening platform that shatters this limitation, running samples 128 times faster than standard methods without sacrificing analytical accuracy.</strong></p><p>Laura breaks down the "orchestra" of technologies making this possible, including coupling nanoliter droplet microfluidics with Cyclic Ion Mobility-Mass Spectrometry (cIM-MS) to separate complex chemical isomers in milliseconds. She also shares the chaotic but triumphant behind-the-scenes stories of her PhD journey—from presenting a "comically bad" early poster at ASMS to recruiting an undergraduate mechanical engineer to build custom automation software from scratch.</p><p>If you are an early-career researcher, a mass spec enthusiast, or curious about the future of synthetic biology and machine learning in chemistry, this episode is packed with invaluable intuition and advice.</p><h3><strong>Video Transcription</strong></h3><h4><strong>From Months to Hours: Droplet Ion Mobility–MS for Biocatalysis Screening</strong></h4><p><strong>High-throughput screening is central to directed enzyme evolution, but conventional analytical workflows can create a difficult compromise: extremely fast screens often provide limited structural information, while techniques such as LC-MS offer much richer chemical insight at the cost of throughput. In a recent interview, analytical chemist Laura described how her work with droplet-based cyclic ion mobility mass spectrometry is helping bridge that gap—providing rapid analysis while retaining the ability to distinguish structurally similar products.</strong></p><p>Her research grew from an initially modest proof of concept into a screening platform capable of analyzing a 96-well plate in roughly ten minutes. The resulting workflow was approximately <strong>128 times faster than a conventional three-minute LC-MS analysis</strong>, opening new possibilities for directed evolution campaigns in which thousands of enzyme variants need to be evaluated.</p><h4>Directed evolution needs better analytical screening</h4><p>Biocatalysis takes advantage of enzymes as highly selective catalysts capable of performing reactions under relatively mild conditions. Directed evolution extends those capabilities by deliberately modifying enzyme sequences, expressing large numbers of variants, screening their activity, and using the best-performing mutants as starting points for subsequent rounds of evolution.</p><p>The process can be repeated multiple times, progressively steering an enzyme toward improved activity, altered substrate specificity, or even chemistry that does not occur naturally.</p><p>But the effectiveness of directed evolution depends heavily on the screening step. The more variants that can be analyzed—and the more useful chemical information that can be collected for each one—the more effectively researchers can explore the enormous sequence space available to an enzyme.</p><p>For Laura, this created a clear analytical challenge: develop a screening platform that was substantially faster than conventional chromatographic analysis without sacrificing the structural discrimination needed for chemically similar products.</p><h4><strong>From an imperfect first experiment to a working platform</strong></h4><p>The project did not begin with a polished high-throughput workflow.</p><p>Laura recalled looking back at her <strong>2023 ASMS poster</strong>, where the early system was still working with standards rather than true isomeric samples. Droplet introduction was slow—around six seconds per droplet—and the signals were far from the ideal reproducible, square, flat-topped profiles expected from replicate droplets.</p><p>Nevertheless, simply producing a droplet signal represented an important first milestone.</p><p>The decisive change came when the project stopped being treated merely as a demonstration that droplet ion mobility–MS could work and instead became a deliberate effort to build a <strong>robust screening platform</strong>.</p><p>Laura approached the problem in modules. First came reliable droplet introduction. Then the ion mobility separation method. Quantification became another independent component. Matrix effects were introduced later, gradually making the system resemble the conditions expected with real screening samples.</p><p>Each layer was tested before another was added.</p><p>This stepwise strategy became one of the central principles of the project: rather than attempting to optimize the entire system simultaneously, individual components were developed, challenged, and then assembled into an increasingly realistic workflow.</p><h4><strong>Finding the middle ground between speed and structural information</strong></h4><p>One of the biggest analytical problems in high-throughput screening is distinguishing products with the same nominal or exact mass.</p><p>Constitutional isomers may contain the same atoms and therefore generate the same mass-to-charge ratio, while differing only in how functional groups are arranged within the molecular structure. Very rapid optical or mass-based screens may therefore struggle to distinguish them.</p><p>Traditional LC-MS can solve many of these problems through chromatographic separation, but a several-minute analysis rapidly becomes impractical when thousands of enzyme variants must be screened.</p><p>Ion mobility offered Laura’s team another option.</p><p>Rather than separating compounds on a chromatographic timescale, ion mobility can differentiate ions according to their gas-phase behavior on a much shorter timescale. In the workflow described in the interview, this created a useful compromise: not the kilohertz throughput possible with some simple screening technologies, but dramatically faster structural differentiation than conventional LC-MS.</p><p>The goal was therefore not simply to achieve the fastest possible screen, but to find a <strong>middle-throughput analytical regime with enough resolving power to answer chemically meaningful questions</strong>.</p><h4><strong>A 96-well plate in about ten minutes</strong></h4><p>That strategy eventually produced one of the most striking results of the project.</p><p>The droplet cyclic ion mobility–MS platform processed a <strong>96-well plate in roughly ten minutes</strong>, while maintaining quantitative results comparable with the conventional LC-MS workflow used for comparison. According to the interview, this represented an approximately <strong>128-fold increase in analysis speed relative to a three-minute LC-MS run</strong>.</p><p>Laura described the successful plate experiment less as a surprise than as confirmation that the modular development strategy had worked.</p><p>Before reaching that point, the workflow had already been challenged through a sequence of increasingly demanding experiments: droplet formation, ion mobility separation, calibration, matrix-containing calibration, and cross-testing analytes at different concentrations. By the time the complete plate was analyzed, each individual part of the analytical system had already been tested under progressively more realistic conditions.</p><h4><strong>What does that speed mean for directed evolution?</strong></h4><p>The impact becomes even clearer when the workflow is considered at the scale of an entire directed-evolution campaign.</p><p>Laura’s manuscript estimated that a <strong>five-round campaign involving 5,000 variants would require approximately 179 days using the conventional LC-MS workflow but only about 14 hours using the new platform</strong>.</p><p>Compressing months of analytical work into less than a day has consequences beyond laboratory productivity.</p><p>It allows researchers to screen more enzyme variants and therefore sample a larger portion of sequence space. But the resulting datasets may also become increasingly valuable for computational approaches.</p><p>Rather than retaining information only about the best-performing enzyme variant, researchers can preserve data describing variants that performed poorly as well as those that succeeded. When genotype and phenotype information remain linked through the well-plate workflow, these larger datasets can potentially provide richer input for machine-learning models designed to guide subsequent rounds of enzyme evolution.</p><p>Faster analysis therefore does more than accelerate an existing experiment—it can change the scale and design of the experiment itself.</p><h4><strong>Balancing ion mobility resolution and signal</strong></h4><p>Increasing cyclic ion mobility separation time can improve resolution, but it also introduces an important trade-off: additional passes can reduce signal.</p><p>Laura optimized this balance experimentally by continuously infusing mixtures containing both isomers and progressively adjusting the ion mobility conditions. After tuning parameters such as wave height and velocity, increasing the separation to <strong>three passes</strong> provided baseline resolution at the high analyte concentrations used during method development.</p><blockquote><p><strong>Concentration, however, also mattered.</strong></p></blockquote><p>At higher ion populations, space-charge effects could broaden peaks and reduce the baseline separation. This meant that the optimal number of passes could not be selected independently of the concentration range required by the final assay.</p><p>Her broader advice for optimization is therefore application-driven: decide first what the analytical method actually needs to accomplish.</p><p>More speed will almost always require sacrificing something—resolution, signal intensity, quantitative precision, or another performance parameter. The key is to identify which compromise the application can tolerate and then optimize the system around that requirement.</p><h4><strong>Solving droplet carryover with a practical compromise</strong></h4><p>Droplet-based workflows present their own engineering challenges, including carryover between neighboring samples.</p><p>In Laura’s system, analytes showed little tendency to partition into the fluorinated oil separating aqueous droplets within the Teflon tubing. The more troublesome carryover occurred closer to electrospray ionization, where a small amount of sample could remain associated with the interface and appear when the next droplet arrived.</p><p>Rather than adding excessive engineering complexity to an already elaborate platform, the researchers adopted a pragmatic solution: a <strong>sacrificial wash droplet</strong> between analytical samples.</p><p>It is an example of a recurring theme throughout the project. The objective was not to construct the theoretically most sophisticated droplet system, but to create a screening workflow that remained sufficiently robust, reproducible, and practical for large numbers of samples.</p><h4><strong>High-throughput analysis also requires high-throughput data processing</strong></h4><p>Accelerating the mass spectrometry experiment created another bottleneck: the data.</p><p>The instrument produced a continuous intensity-versus-time trace rather than a neatly organized well-plate dataset. With small experiments, Laura could manually identify individual droplets and process the results in spreadsheets. That approach quickly became unrealistic as sample numbers increased.</p><p>The solution emerged through collaboration with an undergraduate mentee, Aiden, who helped develop a dedicated software tool for processing the continuous traces.</p><p>Laura defined how the software should behave and how the analytical information should be organized, while Aiden developed the computational implementation. The workflow itself was subsequently adjusted to make automated data processing more reliable—for example, by introducing marker columns that allowed the software to recognize the end of each plate row.</p><p>The resulting tool can accept the acquired traces together with information about plate dimensions and replicates and automatically return parameters including <strong>peak identity, duration, and the corresponding well position</strong>. A later version also generated an automatically populated heat map.</p><p>The experience illustrates how improving analytical throughput often requires simultaneous development of instrumentation, experimental design, and informatics. Making the measurement faster is useful only if the resulting data can be processed at a comparable speed.</p><h4><strong>Mentoring became part of the scientific process</strong></h4><p>The software project also reflects another theme Laura emphasized throughout the interview: the value of mentoring.</p><p>Several younger researchers contributed directly to the development of the final platform. Laura described mentees not simply as additional hands in the laboratory but as scientists capable of proposing their own hypotheses and experimental ideas.</p><p>Working with undergraduate researchers also influenced the way she organized experiments.</p><p>Because their available laboratory time was limited, each task needed to have a clear purpose. That encouraged a more disciplined approach to experimental planning: instead of performing experiments simply because they could be done, the team had to ask which experiment would most efficiently answer the next important question.</p><p>In that sense, mentoring became another mechanism for improving the research itself.</p><h4><strong>The next step: continuous, automated screening</strong></h4><p>Despite the dramatic increase in analytical speed, the current workflow still includes manual operations such as loading tubing and connecting the sample stream to the mass spectrometer.</p><p>The next engineering challenge is therefore automation.</p><p>Laura described ongoing work using the <strong>Venturi effect</strong> to pull samples directly from wells into the droplet system. Building on previous work in the laboratory with 96-well plates, she has already tested this approach with as many as <strong>2,000 samples</strong>.</p><p>The long-term direction is clear: continuous and robust droplet generation, automated handling of thousands of samples, rapid ion mobility separation, mass spectrometric detection, and automated reconstruction of the resulting data into plate-based outputs.</p><p>Combining those elements could move the system closer to the type of large-scale screening required for increasingly ambitious biocatalysis campaigns.</p><h4><strong>Learning mass spectrometry one problem at a time</strong></h4><p>Laura also reflected on the broader experience of developing the platform during her PhD.</p><p>Ion mobility and mass spectrometry initially appeared intimidating, particularly because they combine concepts from analytical chemistry, physical chemistry, separations, instrumentation, and electrical engineering. What eventually changed was not simply learning more facts, but developing the ability to move repeatedly between theory and experiment.</p><p>An unexpected result sends the researcher back to the underlying theory. A better understanding suggests a modified experiment. That experiment creates another observation, gradually building intuition about how the system behaves.</p><p>Her advice to early-career scientists is therefore to accept that this process takes time.</p><p>Advanced analytical techniques may initially appear overwhelming, but understanding develops incrementally through repeated interaction between theory, experimentation, failure, and refinement. Equally important, she emphasized the role of the supportive ion mobility–mass spectrometry community in making a technically demanding field more approachable for young researchers.</p><p>From the first inconsistent droplets to a platform capable of processing thousands of samples, that iterative mindset ultimately shaped the entire project.</p><blockquote><p><strong>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</strong></p></blockquote><blockquote><h4><strong>Concentrating on Chromatography Podcast</strong></h4><p>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!</p><p>You can find <strong>Concentrating on Chromatography Podcast </strong>in podcast apps:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL"><strong>Spotify</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185"><strong>Apple podcast</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography"><strong>podscan</strong></a></li></ul><p>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos"><strong>YouTube channel</strong></a></p></blockquote>

Droplet Cyclic Ion Mobility Mass Spec: Compressing Months of Enzyme Screening Into Just 14 Hours

ISC 2026 - Day 3

Article

Events

Video

Scientists

Interview

The International Symposium on Chromatography (ISC) represents the oldest conference series focussing on separation science. ISC symposia have been organised since 1956 in each even year. ISC is internationally recognised as one of the premier meeting series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.

International Symposium on Chromatography - (ISC)

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Waters SARS-CoV-2 LC-MS Kit (RUO)

Advance virus research with Waters' RUO LC-MS kit for SARS-CoV-2. Detect and quantify NCAP peptides with high sensitivity and reproducibility using SISCAPA antibody enrichment and automation-ready workflows.

<h4><strong>Detect and quantify SARS-CoV-2 NCAP peptides to advance virus research</strong></h4><p>The global <strong>COVID-19 pandemic</strong> created an unprecedented need to quickly deploy emergency tests for SARS-CoV-2 infection. Now, scientists can harness the flexibility and reproducibility of LC-MS to advance critical SARS-CoV-2 research.</p><p><strong>Waters SARS-CoV-2 LC-MS Kit (RUO)</strong> is a <strong>Research Use Only kit</strong> to directly <strong>detect and quantify SARS-CoV-2</strong> signature nucleocapsid peptides (NCAPs) without the need to amplify the target analytes – so you can ensure accuracy, reproducibility, and sensitivity for your most critical research.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_SARS_Co_V_2_LC_MS_Kit_RUO_2_50b4ae9b00/Waters-SARS-CoV-2-LC-MS-Kit-(RUO)-2.jpg" alt="Waters: SARS-CoV-2 LC-MS Kit (RUO)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_SARS_Co_V_2_LC_MS_Kit_RUO_2_50b4ae9b00/thumbnail_Waters-SARS-CoV-2-LC-MS-Kit-(RUO)-2.jpg 234w," sizes="100vw" width="660" height="440"></p><h4><strong>Overview</strong></h4><ul><li>Achieve <strong>reproducible results</strong> between and within labs &nbsp;</li><li>Ensure <strong>high accuracy</strong> and analytical <strong>sensitivity</strong> to enable critical research &nbsp;</li><li><strong>Empower research</strong> and development of pioneering SARS-CoV-2 testing with an alternative and complementary technology to common infectious pathogen research &nbsp;</li><li>Enable <strong>broader research with an LC-MS method </strong>with the potential to be multiplexed with other peptides and biomarkers&nbsp;</li></ul><p><i><strong>* </strong>This kit is for research use only and has not been approved for use in clinical diagnostic procedures. This RUO kit has not been tested with clinical samples. The SARS-CoV-2 kit for SARS-CoV-2 nucleocapsid peptides is not available in all countries, please contact your Waters representative for more details.</i></p><p><strong>Recommended Use:</strong> For the detection and quantification of SARS-CoV-2 signature NCAP peptides.</p><h4><strong>LC-MS enables cutting-edge SARS-CoV-2 research</strong></h4><p>The Waters SARS-CoV-2 LC-MS Kit (RUO) is a Research Use Only kit intended for the quantitative measurement of three proteolytic peptides derived from the SARS-CoV-2 Nucleocapsid (NCAP) protein. The method has been optimized on an <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/199"><strong>ACQUITY UPLC I-Class PLUS</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/195"><strong>Xevo TQ-XS System</strong></a> and is also intended for use with the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/208"><strong>Andrew+ Pipetting Robot</strong></a>. Optimization on other instrument platforms is possible. &nbsp;</p><p>Further investigation is needed to collect objective evidence in promising research applications, however, based on the properties of the analytical test method, the SARS-CoV-2 LC-MS Kit might be leveraged for the following research studies: &nbsp;</p><ul><li>Peptide concentration to quantitate SARS CoV-2 signature peptides at different stages of infection&nbsp;</li><li>Research of infection and long-term effects through peptide quantitation&nbsp;</li></ul><p>Future pandemic preparedness studies and research of signature peptide-based biomarkers unique to other infections </p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_SARS_Co_V_2_LC_MS_Kit_RUO_allows_for_easy_sample_preparation_sample_enrichment_and_sample_detection_f0aca034ad.jpg" alt="Waters: The SARS-CoV-2 LC-MS Kit (RUO) allows for easy sample preparation, sample enrichment, and sample detection." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_SARS_Co_V_2_LC_MS_Kit_RUO_allows_for_easy_sample_preparation_sample_enrichment_and_sample_detection_f0aca034ad.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Achieve confidence in results</strong></h4><p>Ensure accurate and consistent results with highly analytically selective antibody magnetic bead enrichment. With the innovative SISCAPA® anti-peptide antibody enrichment sample preparation method from SISCAPA Assay Technologies, Inc. in the SARS-CoV-2 LC-MS Kit (RUO), you can improve the performance of mass spectrometry for measurement of pre-selected protein targets.</p><p>With the SARS-CoV-2 LC-MS Kit (RUO) and SISCAPA, you can achieve the analytical sensitivity you need to detect low levels of SARS-CoV-2 peptides from complex digested samples with stable isotope standards and capture by anti-peptide antibodies. Increase laboratory efficiency with all the components your busy research laboratory needs to quickly deploy the supplied method - all in one package.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_SARS_Co_V_2_method_minimizes_sample_media_interference_providing_greater_flexibility_for_the_analysis_of_multiple_research_samples_fe3a56c686.jpg" alt="Waters: The SARS-CoV-2 method minimizes sample media interference, providing greater flexibility for the analysis of multiple research samples." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_SARS_Co_V_2_method_minimizes_sample_media_interference_providing_greater_flexibility_for_the_analysis_of_multiple_research_samples_fe3a56c686.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Ensure reproducibility with trusted chemistries and consumables</strong></h4><p>Ensuring reproducible quantitation from sample-to-sample, run-to-run, and lab-to-lab provides the confidence you need for critical research decisions. Ensuring reproducibility starts with minimizing variability risks, including the risk of unpredictable non-specific binding of peptides to surfaces. The SARS-CoV-2 LC-MS Kit uses QuanRecovery Plates with MaxPeak HPS and a MaxPeak Premier Peptide Column, minimizing non-specific binding of peptides to surfaces while enhancing recovery and signal.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Analytical_sensitivity_of_the_ADE_AYN_and_NPA_peptides_in_VTM_at_2_3_5_10_and_20_amol_L_following_antibody_enrichment_145d5249ef.jpg" alt="Waters: Analytical sensitivity of the ADE, AYN, and NPA peptides in VTM at 2, 3, 5, 10, and 20 amolµL following antibody enrichment." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Analytical_sensitivity_of_the_ADE_AYN_and_NPA_peptides_in_VTM_at_2_3_5_10_and_20_amol_L_following_antibody_enrichment_145d5249ef.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Let Andrew+ pipette for you</strong></h4><p>Save valuable time and focus on your research with reliable and reproducible sample preparation using the Andrew+ Pipetting Robot. The SARS-CoV-2 LC-MS Kit (RUO) comes in an automation-friendly format with liquid handling protocols for the Andrew+ Pipetting Robot available on OneLab.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_SARS_Co_V_LC_MS_Kit_RUO_automation_protocol_available_for_Andrew_Pipetting_Robot_It_provides_a_flexible_automation_platform_easily_adaptable_to_multiple_workflows_8dca9a99e0.jpg" alt="Waters: SARS-CoV-LC-MS Kit (RUO) automation protocol available for Andrew + Pipetting Robot. It provides a flexible automation platform easily adaptable to multiple workflows." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_SARS_Co_V_LC_MS_Kit_RUO_automation_protocol_available_for_Andrew_Pipetting_Robot_It_provides_a_flexible_automation_platform_easily_adaptable_to_multiple_workflows_8dca9a99e0.jpg 234w," sizes="100vw" width="1024" height="682"></p>

Waters SELECT SERIES MRT mass spectrometer

Accelerate your research and comprehensively identify analytes in your complex samples with the SELECT SERIES MRT, built with state-of-the-art Multi Reflecting Time-of-Flight (MRT) technology. 

<div><div id="title-089dfa8549" data-locator="title-with-text"><h3><strong>Redefine performance with all the benefits of time-of-flight technology</strong></h3></div></div><div><div id="text-77997605f8" data-locator="text"><p><strong>Accelerate your research and comprehensively identify analytes in your complex samples with the SELECT SERIES MRT, built with state-of-the-art Multi Reflecting Time-of-Flight (MRT) technology. The SELECT SERIES MRT provides a unique combination of ultra-high resolution and specificity independent of scan speed, resulting in unambiguous compound identification with even the most complex samples.</strong></p><p>Distinguish the fine isotope structure of small molecules, resolve nominally isobaric interferences, and baseline resolve the isotopic envelope of multiply-charged ions with high resolution MRT technology. Unlike other high-resolution mass analyzers, SELECT SERIES MRT requires no compromise to your experiments, since mass resolution is consistent over a broad mass range and scan speeds.</p><h3><strong>Overview</strong></h3><div data-locator="section-container-body"><div><div><div data-locator="layoutcontainer-"><div><div id="text-b57ec45d49" data-locator="text"><ul><li>Confidently identify sample components with routine ppb mass accuracy&nbsp;</li><li>Resolve nominally isobaric interferences with high mass resolution, at all scan speeds</li><li>Reveal isotopic fine structure for unambiguous elemental compositions</li><li>Achieve high data quality in both MS and MS/MS</li><li>Simplify data archiving and rapidly process data with reduced data files sizes</li><li>Seamlessly interchange between MALDI, DESI XS and Electrospray sources for superior accuracy for compound identification</li></ul></div></div><div><div id="text-590eba5dee" data-locator="text"><h3><strong>Recommended Use</strong></h3><p>For unambiguous compound identification of even the most complex samples.</p><div><div id="text-d3d9e01296" data-locator="text"><h3 data-locator="modal-title"><strong>High resolution mass spectrometry, without compromise</strong></h3><p>The SELECT SERIES MRT achieves ground-breaking Time-of-Flight (ToF) resolution with the innovative use of multiple reflections of the ion beam between two gridless electrostatic mirrors in the mass analyzer. This extends the ions’ flight&nbsp;path, spatially refocusing the ion packets through a series of periodic lenses after each reflection maintaining sensitivity.&nbsp;Resolution Enhancement Mode (REM) extends the flight path by deflecting ions back for a second pass of the MRT analyzer increasing the resolving power by &gt;50% enabling &gt;300,000 FWHM.</p><figure class="image"><img style="aspect-ratio:1272/897;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Schema_konstrukce_SELECT_SERIES_MRT_Q_Tof_systemu_a07ed0a724/Waters-Schema-konstrukce-SELECT-SERIES-MRT-QTof-systemu.jpg" alt="Waters SELECT SERIES MRT: instrument schematic." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Schema_konstrukce_SELECT_SERIES_MRT_Q_Tof_systemu_a07ed0a724/thumbnail_Waters-Schema-konstrukce-SELECT-SERIES-MRT-QTof-systemu.jpg 221w," sizes="100vw" width="1272" height="897"></figure><p>The superior performance of the SELECT SERIES MRT results in high precision and routine part-per-billion mass accuracy independent of acquisition speed, providing unsurpassed quality of mass spectrometry data and information. The instrument is operated via the SELECT SERIES&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/nav.htm?cid=513164" data-di-id="di-id-e7513c98-b105e917">MassLynx</a>&nbsp;acquisition system with simple and intuitive experimental setup, acquisition, and processing of mass spectrometry data. It records data in the widely deployed Waters .raw file format, which you can easily access via the MassLynx API, export as (i)mzML, and other interchangeable data formats, ready to use in your data analysis strategy.</p><figure class="image"><img style="aspect-ratio:1024/682;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_SELECT_SERIES_MRT_REM_mode_fine_isotope_structure_for_caffeine_1443227594.jpg" alt="Waters SELECT SERIES MRT: REM mode fine isotope structure for caffeine." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_SELECT_SERIES_MRT_REM_mode_fine_isotope_structure_for_caffeine_1443227594.jpg 234w," sizes="100vw" width="1024" height="682"></figure><div><div id="text-78cca88bb7" data-locator="text"><h3 data-locator="modal-title"><strong>Redefining confidence for LC-MS</strong></h3><p>The SELECT SERIES MRT provides a new level of confidence for LC/MS experiments by routinely obtaining ppb mass accuracy, revealing fine isotope structure, all with the exceptional usability of a state-of-the-art Quadrupole Time-of-Flight (QToF). The spectacular performance enables search tolerances to be minimized, providing higher confidence in elemental composition and molecular formula assignments for known and unknown targets. Moreover, the ability to routinely access such high specificity from accurate mass for both precursor and product ions is truly transformative.</p><figure class="image"><img style="aspect-ratio:1024/570;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_SELECT_SERIES_MRT_Resolving_deamidations_for_confident_quantification_356c8f4783.jpg" alt="Waters SELECT SERIES MRT: Resolving deamidations for confident quantification. A) The deamidated forms of peptide HC:T23 elute in the tail of the native peptide peak. Without the ultra-high resolution of the SELECT SERIES MRT as shown in (B) identification and quantification of the deamidations." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_SELECT_SERIES_MRT_Resolving_deamidations_for_confident_quantification_356c8f4783.jpg 245w," sizes="100vw" width="1024" height="570"></figure><div><div id="text-1092d8da82" data-locator="text"><h3 data-locator="modal-title"><strong>Redefining clarity in mass spectrometry imaging</strong></h3><p>The SELECT SERIES MRT reduces analysis times by providing crystal clear, high-resolution images, acquired at fast imaging speeds without compromising mass spectral resolution or accuracy. This enables accelerated mass spectrometry imaging experiments while still resolving analytes from interferences, revealing fine structural information. The cutting-edge technology and intuitive software combine to revolutionize mass spectrometry imaging for a wide range of applications; where the ability to map compounds that differ by only a few mDa is changing the pace of research. This includes:</p><ul><li>Tissue analysis in biomedical research</li><li>Forensic research, including fingerprint analysis</li><li>Surface analysis, ranging from surface contamination analysis for semiconductor production, to analysis of tape stripped skin samples in the cosmetics industry</li></ul><div><div id="text-7f1b1e82f7" data-locator="text"><h3 data-locator="modal-title"><strong>Maximize MS imaging capabilities with DESI and MALDI</strong></h3><p>Maximize your mass spectrometry imaging capabilities and analytical flexibility with both DESI and MALDI on the SELECT SERIES MRT. Pair the SELECT SERIES MRT with <a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/nav.htm?cid=135047466" data-di-id="di-id-5d203d9f-b105e917">DESI XS</a>&nbsp;for high quality data and clear visualization of molecular spatial distributions. The speed and versatility of DESI imaging makes it best suited to the analysis of lipids and other small molecules under ambient, direct analysis conditions, without the need for additional matrices.</p><p>Use the high-performance MALDI source to improve imaging performance and ease-of-use, so you can rapidly image large tissue sections at high spatial resolution with improved selectivity and sensitivity. MALDI’s design uses a tightly focused laser beam profile, increasing signal-to-noise at high spatial resolutions and providing lateral resolution of 15 µm without oversampling, with data acquisition rates &gt;10 pixels per second, so scientists can acquire high intensity images quickly and efficiently. With MALDI and SELECT SERIES MRT, you can:</p><ul><li>Enable imaging of large sections with a full-sized Micro Titre Plate (MTP) format MALDI target plate</li><li>Access high spatial resolution through increased signal to noise (S/N), with a focused laser beam profile</li><li>Simplify usability with an automated isolation valve and laser focus control</li><li>Maximize productivity and uptime with easy cleaning and maintenance</li></ul><figure class="image"><img style="aspect-ratio:1349/1093;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_SELECT_SERIES_MRT_2_8ead9924a6/Waters-SELECT-SERIES-MRT-2.jpg" alt="Waters SELECT SERIES MRT." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_SELECT_SERIES_MRT_2_8ead9924a6/thumbnail_Waters-SELECT-SERIES-MRT-2.jpg 193w," sizes="100vw" width="1349" height="1093"></figure></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Waters Arc Premier LC System

The Arc Premier System features new, innovative MaxPeak High Performance Surfaces (HPS) Technology, which effectively reduces non-specific adsorption due to metal interactions, without complicated mobile phases or laborious methods.

<div><div><h4><strong>See clearly and consistently, with confidence.</strong></h4></div></div><div><div><p><strong>Today’s scientists and lab managers need to confidently produce the most accurate, reliable, and reproducible data. The Arc Premier System produces correct, robust results from the very first injection, reliably and easily.&nbsp;</strong></p><p>The <strong>Arc Premier System</strong> features the new, innovative solution of <strong>MaxPeak High Performance Surfaces (HPS) Technology</strong>, which effectively reduces non-specific adsorption due to metal interaction — without complicated mobile phases or laborious methods. The <strong>Arc Premier System</strong> sharpens chromatographic peaks for <strong>metal-sensitive compounds</strong> by eliminating secondary interactions from metals, resulting in:</p><ul><li>Improved compliance from higher quality data</li><li>Faster, more reproducible, and accurate data integration</li><li>Shorter time from sample to result, without conditioning</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_6d7c95a93a.jpg" alt="Waters Arc Premier LC System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_6d7c95a93a.jpg 245w," sizes="100vw" width="1024" height="611"></p><p>With the Arc Premier System, we continue to deliver on the product quality you expect, combined with recent innovations in <strong>MaxPeak HPS Technolog</strong>y, to always deliver the<strong> best possible results</strong>.&nbsp;</p><p>Whether you are working to ensure the safety of a new and innovative product, maintain the consistency and supply of a current one, or test your food safety and quality, the Arc Premier System gives you<strong> greater data quality, flexibility, reproducibility, and faster data integration </strong>with right first-time results right out of the box, <strong>without the need for complicated mobile phases and laborious methods to prepare your system.</strong></p><div><div><div><div><div><div><ul><li><strong>MaxPeak HPS Technology</strong>, minimizing risk of metal-analyte interactions</li><li>Pressure envelope extends to <strong>9500 psi </strong>through a flow rate range of <strong>1–5 mL/min</strong>, providing an optimized pairing with column dimension and particle size</li><li><strong>Flexible quaternary and binary pumping options</strong></li><li>High performance analytical optical detectors, include photodiode array (PDA), UV/Vis, and fluorescence (FLR)</li><li>Mass detection options with the <strong>ACQUITY™ QDa™ Mass Detector</strong>,<a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1543"> <strong>SQD2 Detector</strong></a>, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/209"><strong>Xevo™ TQ-S micro</strong></a>, and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/212"><strong>Xevo TQ-S cronos</strong></a></li><li>Flexible column manager options available for up to six columns ranging in length from <strong>50 mm to 300 mm</strong>, with a temperature range of <strong>4 °C to 90 °C</strong></li><li><strong>Auto•Blend Plus™ Technology</strong> for mobile phase reproducibility and <strong>Gradient SmartStart</strong> for method transfer</li><li>Wide range of trusted particle technologies in <strong>MaxPeak Premier Columns</strong></li><li>Compliance-ready<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627"><strong>Empower™ Chromatography Data System</strong> </a>(CDS) delivering high quality data integrity</li><li>Automated quantification tools to minimize compliance costs and time</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_2_d1a922ae6d.jpg" alt="Waters Arc Premier LC System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_2_d1a922ae6d.jpg 245w," sizes="100vw" width="1024" height="585"></p></div></div><div><div><h3><strong>Flexible and Robust HPLC Designed for Your Development and Routine Testing Needs</strong></h3><ul><li><strong>Low dispersion HPLC: </strong>High performing HPLC with bandspread of &lt;30 μL for high chromatographic resolution.&nbsp;</li><li><p><strong>Versatile column management: </strong>Support for analytical LC column dimensions up to 300* mm with capacity to automatically select between as many as six analytical columns. Equipped with independently controlled temperature zone, active pre-heating, and<strong> eCord™ Intelligent Chip Technology </strong>for Waters columns.</p><p>* MaxPeak Premier Columns are recommended for use with the Arc Premier System and are currently only available in lengths up to 150 mm.</p></li><li><strong>Flow-through needle Injector: </strong>Volume range of 0.1 to 1000 μL and ultra-low carryover performance compatible with sensitive LC-MS applications.</li><li><strong>High Performance Surfaces Technology: </strong>With MaxPeak HPS Technology, analytes are impeded from Lewis acid-base interactions and adsorptive losses. This technology has proven to be effective in improving the analysis of electron-rich compounds, such as those containing phosphate and carboxylate groups.</li><li><strong>Consumables: </strong>Compatible with MaxPeak Premier Column chemistry to meet the needs of your reversed-phase and HILIC applications. Quality Control (QC) Reference Material benchmarks your Arc Premier System and enables perfect resolution. <strong>Certified clean </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/197"><strong>QuanRecovery™ vials</strong></a> to give full sample integrity.</li><li><strong>High performance analytical detectors : </strong>A wide range of high-performance detection capabilities, optimized with HPS, to support diverse applications. Includes photodiode array, UV/Vis, and fluorescence, with the additional option of single and triple quad mass detection.</li><li><strong>Solvent blending: </strong>Quaternary or binary solvent mixing. Delivers precise and accurate separations at pressures up to 9500 psi. Optional solvent select valve adds access to additional solvents. Automated solvent compressibility, integrated solvent degassing, and programmable seal wash maximize flow accuracy, precision, and reliability.</li><li><strong>Auto•Blend Plus Technology: </strong>Reduce human error and accelerate method robustness testing for chromatographic methods by programming gradients to control mobile phase pH and ionic strength.</li><li><strong>Gradient SmartStart: </strong>Adjust the injection relative to the gradient start to emulate other HPLC systems’ dwell volumes, without the need to alter the gradient table. Successfully transfer most methods in just two injections.</li><li><strong>Laboratory Informatics: </strong>Software control within your existing <strong>Empower </strong>or <strong>MassLynx™ </strong>infrastructure. Empower Method Validation Manager (MVM) allows you to perform chromatographic method validation in one application. Optional S-Matrix Fusion Software automates your method development according to AQbD guidelines.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_3_5db411b90a.jpg" alt="Waters Arc Premier LC System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_3_5db411b90a.jpg 234w," sizes="100vw" width="1024" height="682"></p></div></div></div></div><div><div><div><div><div><div><h3><strong>The Universal Platform for Liquid Chromatography</strong></h3><p>Non-specific adsorption of metal-sensitive compounds is an unpredictable challenge, resulting in chromatography with large relative standard deviations (RSDs) and broad, overlapping peaks, which can be challenging to integrate quickly and be accurate consistently.</p><p>Designed with MaxPeak HPS Technology and paired with <strong>MaxPeak Premier 2.5 μm Columns</strong>, the Arc Premier System improves data quality for challenging compounds, including metal-sensitive compounds tested with LC methods – so you can see clearly and consistently, with confidence.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_8_a4038daa52.jpg" alt="Waters Arc Premier LC System: Figure 1. Analysis of adenosine monophosphate, adenosine diphosphate, and adenosine triphosphate. Significant improvements to sensitivity and recovery are observed with the Arc Premier Solution compared to a conventional LC system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_8_a4038daa52.jpg 245w," sizes="100vw" width="1123" height="520"></p></div></div></div></div></div></div></div></div><div><div><h3><strong>Clear</strong></h3><p>Future-proof your lab for the next generation of challenging compounds with MaxPeak HPS Technology, which sharpenspeaks for metal-sensitive compounds, resulting in higher data quality and improved sensitivity with chromatographic reproducibility and precision.</p><p>Data quality and performance are <strong>critical </strong>for your lab, but those can’t come at the sacrifice of ruggedness and ease of use.&nbsp;</p><p>With MaxPeak HPS Technology and flexible LC performance, your lab gets the typical benefits of an LC system optimized for <strong>2.x μm column chemistry </strong>with the MaxPeak HPS Technology’s ability to shorten run times and achieve sharp peaks - no lengthy and complex conditioning and conditioning methodologies for metal-sensitive compounds required.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_9_34ec4befec.jpg" alt="Waters Arc Premier LC System: Figure 2. Analysis of adenosine triphosphate. Lower limits of detection and increased calibration curve linearity are demonstrated with the Arc Premier Solution compared to a conventional LC system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_9_34ec4befec.jpg 245w," sizes="100vw" width="940" height="523"></p></div></div><div><div><h3><strong>Consistent</strong></h3><p>Seeing your results more clearly than ever is critical, but those results must be consistent and error-free and your methods easily reproducible, so you can spend less time on analysis and ensure compliance.&nbsp;</p><p>By <strong>significantly sharpening peak shapes</strong> for metal-sensitive analytes, scientists report an improvement in %RSD when integrating data from metal-sensitive compounds on the Arc Premier System. Along with the improvement in data consistency users also report a decrease of time needed to integrate peaks by <strong>approximately 30%</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_f80500f8a4.jpg" alt="Waters Arc Premier LC System: Figure 3. Analysis of hydrocortisone phosphate, betamethasone phosphate, dexamethasone, and dexamethasone acetate. Peak heights increased and peak shapes are more symmetrical for metal- sensitive compounds on the Arc Premier Solution compared to a conventional LC system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_f80500f8a4.jpg 235w," sizes="100vw" width="1381" height="918"></p><p>The Arc Premier System <strong>eliminates </strong>the need for<strong> variability-prone conditioning and complex mobile phases</strong> – so you can minimize user errors, improve compliance, and reduce expensive audits from red flag-inducing conditioning injections.</p><p>Your organization needs to reliably migrate higher-quality methods between your systems for maximum reproducibility. With MaxPeak HPS Technology and flexible pump configurations, your lab can easily, reliably <strong>migrate methods between MaxPeak HPS-based systems </strong>quickly, saving you time and money from unnecessary rework. You can also<strong> migrate methods from non-MaxPeak HPS-enabled systems </strong>safely, as method performance of non-metal-sensitive compounds have been shown to not be adversely affected.</p><p>Combining higher data quality with ease of use for your analysts and seamless method transfer, enables results that can be generated consistently between runs and with various analysts.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_6_5332aab31f.jpg" alt="Waters Arc Premier LC System: Figure 4. Analysis of hydrocortisone phosphate, betamethasone phosphate, dexamethasone, and dexamethasone acetate. A zoom in on the baseline shows improved peak shapes and resolution for metal-sensitive compounds on the Arc Premier Solution compared to a conventional LC system, improving baseline resolution." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_6_5332aab31f.jpg 229w," sizes="100vw" width="1380" height="942"></p><h3><strong>Confident</strong></h3><p><strong>Reducing analytical uncertainty and achieving peace</strong> of mind are important for your organization. With MaxPeak HPS Technology, metal-sensitive analytes become visible that were previously undetectable. This allows you to quickly and confidently know that you’ve seen everything in your sample, giving you the confidence to stand behind your data-driven decisions.</p><p>The <strong>combination of MaxPeak HPS Technology, flexible pump and column management options, and precise optical and MS detection</strong> give you the method development and verification capabilities to know that no matter the sample - you can deliver a robust method you can stand behind.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_2_85f2f7cc29.jpg" alt="Waters Arc Premier LC System: Figure 5. Analysis of data of hydrocortisone phosphate, betamethasone phosphate, dexamethasone, and dexamethasone acetate from an Arc Premier System and a conventional LC system by six users. Peak area reproducibility improved 9 – 124x when integrating the same data from metal-sensitive compounds across six users." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_2_85f2f7cc29.jpg 239w," sizes="100vw" width="1243" height="810"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_5_514749f32d.jpg" alt="Waters Arc Premier LC System: Figure 6. Analysis of acetaminophen, caffeine, leucine enkephalin, sulfadimethoxine, amitriptyline, reserpine, and terfenadine shows that non-metal-sensitive compounds demonstrate comparable performance between the Arc Premier Solution and conventional LC systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_5_514749f32d.jpg 245w," sizes="100vw" width="1242" height="735"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_7_edc8ecaa93.jpg" alt="Waters Arc Premier LC System: Figure 7. Comparison of adenosine triphosphate and adenosine diphosphate peaks using a conventional LC system and the Arc Premier Solution over 120 injections. The peak areas of metal-sensitive compounds remain constant from the first to the 120th injection using the Arc Premier Solution. Peak areas of metal-sensitive compounds on a conventional LC system continuously increase over time and do not stabilize even after 120 injections." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_7_edc8ecaa93.jpg 218w," sizes="100vw" width="1038" height="744"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_3_f1cca337bc.jpg" alt="Waters Arc Premier LC System: Figure 8. Comparison of adenosine triphosphate and adenosine diphosphate peaks using a conventional LC system and the Arc Premier Solution over 120 injections. The peak areas of metal-sensitive compounds remain constant from the first to the 120th injection using the Arc Premier Solution showing less than a 1% change in peak area for all compounds. Peak areas of metal-sensitive compounds on a conventional LC system show an increase of 2–35% when compared to the first injection and show no signs of stabilization." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_3_f1cca337bc.jpg 216w," sizes="100vw" width="1039" height="750"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Arc_Premier_LC_System_4_1dae3909ae.jpg" alt="Waters Arc Premier LC System: Figure 9. Adenosine triphosphate, adenosine diphosphate, adenosine monophosphate, and adenosine stability using the Arc Premier Solution over 1000 injections. The peak areas of metal-sensitive compounds remain consistent over 1000 injection using the Arc Premier Solution demonstrating the robustness of the system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Arc_Premier_LC_System_4_1dae3909ae.jpg 243w," sizes="100vw" width="1040" height="669"></p></div></div></div></div>

Waters SEC Columns

Get unmatched batch-to-batch reproducibility with the wide range of Waters Size-Exclusion Chromatography (SEC) Columns and standards for protein and peptide characterization.

<h4><strong>Size-based separations of peptides, proteins, nucleic acids, LNPs, and viral vectors</strong></h4><p>Get unmatched batch-to-batch reproducibility with the wide range of <strong>Waters Size-Exclusion Chromatography (SEC) Columns</strong> and standards for protein and peptide characterization.</p><p><strong>SEC</strong> is a powerful technique for aggregate and fragment analysis in the <strong>research, development</strong>, and <strong>manufacturing of biotherapeutic proteins</strong>, such as <strong>insulin</strong> and <strong>monoclonal antibodies</strong> (mAb). With SEC, also known as gel filtration, you can separate proteins based on their size (hydrodynamic radii versus absolute molecular weight) in solution, with larger sized species eluting before smaller proteins.</p><p>The <strong>pore size and volume</strong> of the SEC particles used in the packed column drives this <strong>isocratic based technique</strong>, so the column you choose matters. As the molecular weight of the proteins of interest increases, SEC columns with comparatively larger pore size particles are selected.</p><h4><strong>Overview</strong></h4><ul><li>Gain efficiency with this “platform based” method for <strong>proteins ranging from 10,000 to 650,000 Daltons</strong>, leveraging <strong>MaxPeak Premier Technology</strong> coupled with <strong>BEH-PEO Particle Technology&nbsp;</strong> &nbsp;&nbsp;</li><li><strong>Minimize non-desired secondary interactions </strong>for improved separation reproducibility and results with Ethylene Bridged Hybrid (BEH) SEC particles</li><li>Ensure reliable <strong>column-to-column and batch-to-batch performance</strong> with columns quality control tested with relevant peptide, protein, and mAb samples &nbsp;</li><li>Achieve reliable <strong>high throughput analysis on UPLC</strong> systems with our <strong>1.7 µm particle size</strong> offering and reproducible separations on any <strong>HPLC, UHPLC, or UPLC system</strong> to address different application needs with <strong>2.5 µm&nbsp;</strong></li><li><strong>Extend analytical column life</strong> and<strong> lower cost per analyses </strong>with SEC Guards&nbsp;</li><li>Confirm on-site SEC column and LC system performance with available BEH125, BEH200, BEH450, and mAb Size Variant Standards &nbsp;&nbsp;</li><li><strong>Manufactured in a cGMP, ISO 9001</strong> certified plant using stringent manufacturing protocols and ultra-pure reagents</li></ul><p><strong>Recommended Use: </strong>For size-based peptide, protein, and viral vector analyses.</p><h4><strong>System Dispersion Specifications for Column Recommendations</strong></h4><h5><strong>LC System Dispersions &lt;20 µL (UPLC)</strong></h5><ul><li>ACQUITY Premier Protein SEC 250 Å Guards and Columns</li><li>ACQUITY UPLC Protein BEH SEC 125 Å, 200 Å, and 450 Å Guards and Columns</li><li>1.7 µm guards and columns for low dispersion UPLC systems</li></ul><h5><strong>LC System Dispersions &gt;20 µL – ≤35 µL (UHPLC)</strong></h5><ul><li>XBridge Premier Protein SEC 250 Å Guards and Columns</li><li>XBridge Protein BEH SEC 125 Å, 200 Å, and 450 Å Guards and Columns</li><li>BioResolve mAb SEC Guards and Columns</li><li>2.5 µm guards and columns for UHPLC systems</li></ul><h5><strong>LC System Dispersions &gt;35 µL (HPLC)</strong></h5><ul><li>XBridge Protein BEH SEC 125 Å, 200 Å, and 450 Å Guards and Columns</li><li>XBridge Premier Protein SEC 250 Å Guards and Columns</li><li>BioResolve mAb SEC Guards and Columns</li><li>BioSuite SEC Guards and Columns</li><li>3.5 µm guards and columns for HPLC systems</li></ul><h4><strong>GTxResolve SEC Columns</strong></h4><h5><strong>GTxResolve Premier BEH SEC 450 Å Columns</strong></h5><ul><li>2.5 µm particle size columns for UHPLC and UPLC separations</li><li>Lower secondary interactions and lower noise suitable for platform methods</li><li>Low adsorption hardware necessary for analysis of biologics samples</li><li>450 Å pore size with up to 50% higher resolving power reducing need for sample consumption, resulting in faster analyses<ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/us/en/products/columns/GTxResolve-sec-columns.html"><strong>Explore GTxResolve SEC Columns</strong></a></li></ul></li></ul><h5><strong>GTxResolve Premier SEC 1000 Å Columns</strong></h5><ul><li>3 µm columns for UHPLC and UPLC separations</li><li>1000 Å columns with high efficiency for aggregate analysis of GTx drugs with diameter of 80-200 nm</li><li>Low secondary interaction &amp; improved compatibility with universally applied detector, such as MALS</li><li>Low adsorption hardware necessary for analysis of biologics samples<ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/us/en/products/columns/GTxResolve-sec-columns.html"><strong>Explore GTxResolve SEC Columns</strong></a></li></ul></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_G_Tx_Resolve_SEC_Columns_1b8741a62b.jpg" alt="Waters: GTxResolve SEC Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_G_Tx_Resolve_SEC_Columns_1b8741a62b.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Protein SEC Columns</strong></h4><h5><strong>ACQUITY Premier Protein SEC 250 Å Guards and Columns</strong></h5><ul><li>Sub-2-μm particle columns for UPLC separations</li><li>250 Å pore size</li><li>High throughput &amp; resolution SEC separations of biomolecules ranging from 10,000 to 650,000 Daltons on low dispersion UPLC Systems</li><li>Available SEC Guard Columns to extend analytical SEC Column life</li><li>Significantly reduce non-desired ionic and hydrophobic secondary interaction for desired SEC platform methods with MaxPeak Premier Technology and BEH-PEO SEC particle technology<ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/us/en/products/columns/acquity-premier-columns.html"><strong>Explore ACQUITY Premier Protein BEH SEC Guards and Columns</strong></a></li></ul></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_ACQUITY_Premier_Columns_featuring_Max_Peak_HPS_Technology_11a541350e.jpg" alt="Waters: ACQUITY Premier Columns featuring MaxPeak HPS Technology" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_ACQUITY_Premier_Columns_featuring_Max_Peak_HPS_Technology_11a541350e.jpg 234w," sizes="100vw" width="1024" height="682"></p><h5><strong>XBridge Premier Protein SEC 250 Å Guards and Columns</strong></h5><ul><li>2.5 μm particle columns for HPLC and UHPLC separations</li><li>250 Å pore size</li><li>High resolution SEC separations of biomolecules ranging from 10,000 to 650,000 Daltons on any LC system</li><li>Available SEC Guard Columns to extend analytical SEC Column life</li><li>Significantly reduce non-desired ionic and hydrophobic secondary interaction for desired SEC platform methods with MaxPeak Premier Technology and BEH-PEO SEC particle technology</li><li>Specifically designed and QC tested with NIST-based, mAb Size Variant Standard to help ensure batch-to-batch consistency<ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/global/Waters-XBridge-Premier-Columns/nav.htm"><strong>Explore XBridge Premier Protein BEH SEC Columns</strong></a></li></ul></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_X_Bridge_Premier_Columns_0230c90278.jpg" alt="Waters: XBridge Premier Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_X_Bridge_Premier_Columns_0230c90278.jpg 193w," sizes="100vw" width="950" height="768"></p><h5><strong>BioResolve mAb SEC Guards and Columns</strong></h5><ul><li>2.5 μm particle columns for UPLC, UHPLC, and HPLC separations</li><li>200 Å pore size</li><li>Obtain reproducible, accurate quantitation of monoclonal antibodies (mAbs), associated high molecular weight aggregates (&gt;300,000 Da), and lower molecular weight fragments (e.g., &lt;100,000 Da)</li><li>Each packed column is tested with NIST-based, mAb size variant standard to help ensure batch-to-batch and column-to-column performance consistency<ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/global/BioResolve-SEC-mAb-Consumables-%7C-SEC-Guards/nav.htm"><strong>Explore BioResolve mAb SEC Guards and Columns</strong></a></li></ul></li></ul><h5><strong>ACQUITY UPLC Protein BEH SEC Guards and Columns</strong></h5><ul><li>Sub-2-μm particle columns for UPLC separations (2.5 μm for 450 Å)</li><li>Pore size options include: 125 Å, 200 Å, and 450 Å</li><li>Available SEC Guard Columns to extend analytical SEC Column life</li><li>Specifically designed and QC tested with BEH125, BEH200, or BEH450 protein standards to help ensure batch-to-batch consistency</li><li>10x faster than traditional HPLC-based SEC<ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/us/en/products/columns/acquity-uplc-columns.html"><strong>Explore ACQUITY UPLC Protein BEH SEC Guards and Columns</strong></a></li></ul></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Acquity_UPLC_kolony_1dc5c25d3e/Waters-Acquity-UPLC-kolony.jpg" alt="Waters: Acquity UPLC columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Acquity_UPLC_kolony_1dc5c25d3e/thumbnail_Waters-Acquity-UPLC-kolony.jpg 245w," sizes="100vw" width="807" height="407"></p><h5><strong>XBridge Protein BEH SEC Columns</strong></h5><ul><li>2.5 μm particle columns for use on any UPLC, UHPLC, or HPLC system</li><li>Pore size options include: 125 Å, 200 Å, and 450 Å</li><li>Available SEC Guard Columns to extend analytical SEC Column life</li><li>Specifically designed and QC tested with BEH125, BEH200, or BEH450 protein standards to help ensure batch-to-batch consistency<ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/global/XBridge-BEH-Columns-for-High-pH-Chromatography/nav.htm"><strong>Explore XBridge Protein BEH SEC Columns</strong></a></li></ul></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_X_Bridge_Columns_b0b55de501/Waters-XBridge-Columns.jpg" alt="Waters: XBridge Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_X_Bridge_Columns_b0b55de501/thumbnail_Waters-XBridge-Columns.jpg 203w," sizes="100vw" width="900" height="691"></p><h4><strong>Peptide SEC Columns</strong></h4><h5><strong>BioSuite SEC Columns</strong></h5><ul><li>Silica-based diol SEC columns</li><li>Molecular weight exclusion limits are determined primarily by the selected pore size</li><li>Available in analytical and semi-preparative column sizes<ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/global/BioSuite-Columns/nav.htm"><strong>Explore BioSuite SEC Columns</strong></a></li></ul></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Bio_Suite_Columns_bf2bb8249f.jpg" alt="Waters: BioSuite Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Bio_Suite_Columns_bf2bb8249f.jpg 184w," sizes="100vw" width="307" height="260"></p><h5><strong>Protein-Pak SEC Columns</strong></h5><ul><li>Based on a 10 μm diol-bonded silica</li><li>Resolve proteins that differ in molecular weight by a factor of two</li><li>Distinguish proteins differing by as little as 15% in molecular weight<ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/global/Protein-Pak-HPLC-and-UPLC-Columns/nav.htm"><strong>Explore Protein-Pak SEC Columns</strong></a></li></ul></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Protein_Pak_Columns_be6a669326.jpg" alt="Waters: Protein-Pak Columns" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Protein_Pak_Columns_be6a669326.jpg 245w," sizes="100vw" width="500" height="315"></p><h4><strong>Choose the right SEC Column for your lab</strong></h4><p>SEC is ideal for aggregate and fragment analysis in the research, development, and manufacturing of biotherapeutic peptides, proteins, and viral vectors, but choosing the right column for your analysis is important. Use the following criteria to choose a column that provides reliable, high quality SEC analyses of various biomolecules, including insulin, monoclonal antibodies, and adeno associated viruses (AAVs).</p><h5><strong>What to consider when choosing an SEC Column:</strong></h5><ul><li>What is the molecular weight of your sample?</li><li>What is the dispersion of your LC system?</li><li>Are you separating components &lt;2 fold difference in molecular weight (MW)?</li><li>Are you separating components &gt;2 fold difference in MW?</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Choose_the_right_Size_exclusion_chromatography_SEC_column_for_your_analysis_with_Waters_SEC_columns_selection_guide_b81f674f65.jpg" alt="Waters: Choose the right Size-exclusion chromatography (SEC) column for your analysis with Waters SEC columns selection guide." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Choose_the_right_Size_exclusion_chromatography_SEC_column_for_your_analysis_with_Waters_SEC_columns_selection_guide_b81f674f65.jpg 158w," sizes="100vw" width="1024" height="1013"></p><h4><strong>Addressing the complexity of SEC Separations</strong></h4><p>Experience the advancements in SEC-based technologies to address non-desired specific ionic and hydrophobic interactions for more reliable results with ACQUITY Premier Protein SEC and XBridge Premier Protein SEC Columns and Guards.</p><h5><strong>With MaxPeak Premier SEC Columns, you can:</strong></h5><ul><li>Reproducibly resolve injected sample components that are less than 2x different in size for challenging applications</li><li>Use a ‘platform SEC method’ to reduce method development time and cost</li><li>Ensure batch-to-batch and column-to-column performance</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Classes_of_therapeutic_proteins_separated_on_an_ACQUITY_Premier_Protein_SEC_Column_d3f74a8ea4.jpg" alt="Waters: Classes of therapeutic proteins separated on an ACQUITY Premier Protein SEC Column." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Classes_of_therapeutic_proteins_separated_on_an_ACQUITY_Premier_Protein_SEC_Column_d3f74a8ea4.jpg 234w," sizes="100vw" width="1024" height="682"></p>

Waters Atlantis Premier BEH Z-HILIC Column

Waters Atlantis Premier BEH Z-HILIC Columns provide an increase in polar analyte retention and offer a different selectivity when compared to other HILIC chemistries, both powerful attributes when performing HILIC methods development.

<p><strong>Atlantis Premier BEH Z-HILIC Columns </strong>provide an increase in polar analyte retention and offer a different selectivity when compared to other HILIC chemistries, both powerful attributes when performing HILIC methods development. &nbsp;Built using rugged <strong>ethylene bridged hybrid particles</strong>, these columns are <strong>pH stable from pH 2-10</strong>; the MaxPeak High Performance Surface hardware technology significantly reduces unwanted analyte/surface interactions that can lead to poor peak shape and losses in signal intensity.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Atlantis_Premier_BEH_Z_HILIC_kolony_1_59d95946d7/Waters-Atlantis-Premier-BEH-Z-HILIC-kolony-1.jpg" alt="Waters: Atlantis Premier BEH Z-HILIC column" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Atlantis_Premier_BEH_Z_HILIC_kolony_1_59d95946d7/thumbnail_Waters-Atlantis-Premier-BEH-Z-HILIC-kolony-1.jpg 234w," sizes="100vw" width="660" height="440"></p><h4><strong>Specification</strong></h4><ul><li><strong>Chemistry:</strong> Sulfobetaine</li><li><strong>Separation Mode: </strong>Hydrophilic Interaction (HILIC)</li><li><strong>Particle Substrate: </strong>Hybrid</li><li><strong>pH Range Min: </strong>2 pH</li><li><strong>pH Range Max:</strong> 10 pH</li><li><strong>Maximum Pressure:</strong> 18000 psi (1240 Bar)</li><li><strong>Endcapped: </strong>No</li><li><strong>Bonding Technology:</strong> Zwitterion</li><li><strong>Particle Shape:</strong> Spherical</li><li><strong>Particle Size:</strong> 1.7 µm</li><li><strong>Endfitting Type: </strong>Parker-style</li><li><strong>Pore Size: </strong>95 Å</li><li><strong>Format: </strong>Premier Column</li><li><strong>Surface Area:</strong> 270</li><li><strong>System:</strong> UHPLC, UPLC</li><li><strong>Particle Technology: </strong>BEH</li><li><strong>USP Classification:</strong> L122</li><li><strong>Carbon Load: </strong>17 %</li></ul><h3><strong>Atlantis Premier Columns</strong></h3><h4><strong>Next-generation hybrid particle and surface technology for increased polar analyte retention</strong></h4><p>Retaining polar compounds is one of the most challenging chromatographic problems. With the hybrid particle technology in Atlantis Premier BEH C18 AX and the BEH Z-HILIC Columns, those problems are a thing of the past. These reversed-phase, anion-exchanged, mixed-mode, and zwitterionic columns are the next evolution of columns in the Atlantis family, all designed to achieve superior polar compound retention.</p><p>Atlantis Premier BEH C18 AX and the BEH Z-HILIC Columns combine a new and innovative chromatographic particle technology with proprietary MaxPeak High-Performance Surfaces (HPS) Technology to boost retention of polar acidic compounds by 50% while eliminating unwanted analyte-surface interactions.</p><h4><strong>Atlantis Premier Column Characteristics</strong></h4><h5><strong>Atlantis Premier BEH 95 Å Particle Columns</strong></h5><ul><li>Mixed-mode C18 Anion-exchange (AX) Chemistry</li><li>Increase retention of polar acids</li><li>Wider pH range (2–10)</li><li>Batch-to-batch reproducibility</li><li>Mass Spectrometry (MS) compatible</li></ul><h5><strong>Atlantis Premier BEH Z-HILIC Columns</strong></h5><ul><li>Uses sulfobetaine zwitterionic ligand</li><li>Increase retention of strongly polar analytes</li><li>Wider pH range (2–10)</li><li>Batch-to-batch reproducibility</li><li>Mass Spectrometry (MS) compatible</li></ul>

Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer

The Xevo™ TQ Absolute combines Absolute performance, efficiency, productivity, and confidence to give you the Absolute Power to quantitate your most challenging compounds and make fast decisions.

<h3><strong>Quantitate with Absolute Power</strong></h3><ul><li><strong>Harness Absolute Power for Confident, Fast Decisions</strong></li></ul><p><strong>The Xevo™ TQ Absolute combines Absolute performance, efficiency, productivity, and confidence to give you the Absolute Power to quantitate your most challenging compounds and make fast decisions.</strong></p><h4><strong>Absolute&nbsp;Performance</strong></h4><p>Achieve lower limits of quantitation to meet regulatory requirements with up to <strong>15x more sensitivity</strong> for challenging negative ionizing compounds than the previous product.</p><h4><strong>Absolute Efficiency &nbsp;</strong></h4><p>Achieve improved environmental sustainability and lower your laboratory operational costs with an instrument that uses <strong>up to 50% less electricity and gas and produces 50% less heat</strong> than most other high performance TQ mass spectrometry instruments on the market.</p><h4><strong>Absolute&nbsp;Productivity</strong></h4><p>Boost your productivity with flexible software solutions, including waters_connect,™ the modern, intuitive informatics solution that can<strong> save up to 50% of your data review time </strong>while facilitating data integrity.&nbsp;</p><h4><strong>Absolute Confidence</strong></h4><p>Ensure consistent robustness and reproducibility so you can <strong>maintain performance and productivity </strong>over a longer time period.</p><h3><strong>Absolute Performance</strong></h3><h4><strong>Increased sensitivity with lower limits of quantitation</strong></h4><p>One of the largest challenges facing many labs is the need to achieve lower limits of quantitation and meet regulatory requirements, particularly for challenging negative ionizing compounds.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Corporation_Waters_Xevo_TQ_Absolute_poskytuje_6x_15x_lepsi_citlivost_nez_jeho_predchudci_6ae9af3f1d/Waters-Corporation-Waters-Xevo-TQ-Absolute-poskytuje-6x-15x-lepsi-citlivost-nez-jeho-predchudci.webp" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: *Xevo TQ Absolute shows up to 15x better ion response as compared to the Xevo TQ-XS and up to 6x better ion response than another leading high-performance LC-MS/MS instrument." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Corporation_Waters_Xevo_TQ_Absolute_poskytuje_6x_15x_lepsi_citlivost_nez_jeho_predchudci_6ae9af3f1d/thumbnail_Waters-Corporation-Waters-Xevo-TQ-Absolute-poskytuje-6x-15x-lepsi-citlivost-nez-jeho-predchudci.webp 245w," sizes="100vw" width="1024" height="540"></p><p>Ensure you have the confidence in your data to make decisions fast with an instrument that provides Absolute Performance. <strong>Xevo TQ Absolute delivers up to 15x better sensitivity for challenging negative ionizing compounds</strong> than the previous product, so you can make decisions quickly and efficiently.</p><h3><strong>Absolute Efficiency</strong></h3><h4><strong>Lower operational costs and improved sustainability</strong></h4><p>As a leading technology innovator in chromatography, mass spectrometry, and thermal analysis instruments and software, Waters shares a common mission with our customers: to leave the world a better place than we found it.&nbsp;</p><p>Many of our customers are actively working to address environmental sustainability in balance with the need to continually reduce operational costs. During development of the Xevo TQ Absolute, Waters has addressed these challenges by providing an instrument with lower electricity consumption, gas consumption, and BTU/hr output – lessening the need for air conditioning and lowering costs.</p><p>The Xevo TQ Absolute also provides more analytical capability per square foot of lab space by minimizing the LC-MS/MS footprint, enabling laboratory managers to fully optimize their facilities and increase efficiency.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_Absolute_Triple_Quadrupole_Mass_Spectrometer_Absolute_Efficiency_1b0bcac3ac.jpg" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: Absolute Efficiency." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_Absolute_Triple_Quadrupole_Mass_Spectrometer_Absolute_Efficiency_1b0bcac3ac.jpg 206w," sizes="100vw" width="1050" height="794"></p><p>*Source: <a target="_blank" rel="noopener noreferrer" href="https://sciex.com/content/dam/SCIEX/pdf/customer-docs/site-planning-guide/7500-site-planning-guide-en.pdf">https://sciex.com/</a></p><h3><strong>Absolute Productivity</strong></h3><h4><strong>Achieve more with flexible software solutions&nbsp;</strong></h4><p>In an ever-changing environment, flexibility can help protect against future unknowns. The Xevo TQ Absolute is available on both our waters_connect and MassLynx™ Software platforms, providing the ultimate flexibility to choose a future-proof solution to meet your lab requirements</p><h5><strong>waters_connect</strong></h5><p>Our modern, app-based software platform, waters_connect, delivers efficiency and usability benefits, including the unique Exception Focused Review (XFR) functionality that can save up to 50% of your data review time, ensuring your lab is as productive as possible.</p><h5><strong>MassLynx</strong></h5><p>Our tried and well-established MassLynx Software package delivers market-leading versatility and flexibility for all application areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: Convert data into meaningful results with waters_connect and MassLynx." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_S_micro_Triple_Quadrupole_Mass_Spectrometry_Convert_data_into_meaningful_results_with_waters_connect_and_Mass_Lynx_028cc58bc8.jpg 245w," sizes="100vw" width="1024" height="346"></p><h3><strong>Absolute Confidence</strong></h3><h4><strong>Tackle your toughest challenges</strong></h4><p>Analytical laboratories face several challenges that are constantly changing, so it’s important to have Absolute Confidence that your analytical instrumentation can keep pace.&nbsp;</p><p>The Xevo TQ Absolute has been specifically developed to deliver consistent robustness and reproducibility, so you can maintain performance and productivity over a longer time period.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Corporation_Novy_stit_iontoveho_zdroje_hmotnosniho_spektrometru_Waters_Xevo_TQ_Absolute_0ef51bf805/Waters-Corporation-Novy-stit-iontoveho-zdroje-hmotnosniho-spektrometru-Waters-Xevo-TQ-Absolute.webp" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: New source shield technology featured in the Xevo TQ Absolute Mass Spectrometer minimizes contamination and increases uptime." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Corporation_Novy_stit_iontoveho_zdroje_hmotnosniho_spektrometru_Waters_Xevo_TQ_Absolute_0ef51bf805/thumbnail_Waters-Corporation-Novy-stit-iontoveho-zdroje-hmotnosniho-spektrometru-Waters-Xevo-TQ-Absolute.webp 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Better by design</strong></h4><p>Optimal probe positioning guidance ensures you can achieve the best possible performance while minimizing contamination and reducing the need for inconvenient downtime to clean the instrument. A new source shield maximizes uptime by minimizing contamination of the source from sample matrix or mobile phase salts.</p><h3><strong>Absolute Support</strong></h3><h4><strong>Ensure your success with world-renowned services</strong></h4><p>Waters Service and Support helps maintain system peak performance, minimize downtime, address scientific application challenges, and support stringent compliance requirements.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_Absolute_tandemovy_hmotnostni_spektrometr_2_f0a5cb429c/Waters-Xevo-TQ-Absolute-tandemovy-hmotnostni-spektrometr-2.webp" alt="Waters Xevo TQ Absolute Triple Quadrupole Mass Spectrometer: Absolute support." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_Absolute_tandemovy_hmotnostni_spektrometr_2_f0a5cb429c/thumbnail_Waters-Xevo-TQ-Absolute-tandemovy-hmotnostni-spektrometr-2.webp 234w," sizes="100vw" width="1024" height="682"></p><p><strong>Waters award-winning consistent quality support and professional services ensure your success wherever your laboratory is located in the world. With Waters Service and Support offerings* for your Xevo TQ Absolute, you can:</strong></p><h4><strong>Get Up And Running Quicly</strong></h4><p>Get the onsite training and consultation you need to integrate the Xevo TQ Absolute into your laboratory and assist with data migration and method transfer needs with Waters Professional Services.</p><h4><strong>Meet Your Lab’s Unique Requirements&nbsp;</strong></h4><p>Protect your high-performance instrument investment with the comprehensive portfolio of service plans from Waters FlexCHOICE, which provides access to the most in-depth and up-to-date knowledge of the advanced science and technologies within Waters systems.</p><h4><strong>Facilitates Compliance</strong></h4><p>Simplify the process of qualification, validation, and record-keeping so that your business can focus on delivering products to market with Waters Compliance Services – so you can meet the regulations in your industry and in the countries where you conduct business.</p><h4><strong>Reduce Total Cost Of Ownership</strong></h4><p>FlexCAPITAL<strong>** </strong>is designed to support continuous laboratory operation while satisfying the budgeting challenges of a constantly shifting landscape. Minimize total cost of ownership while optimizing instrument performance and protecting your organization from security risks associated with outdated software platforms.</p><h4><strong>Leverage Your Existing Technology</strong></h4><p>With the FlexUP technology renewal program, you can upgrade your older tandem quadrupole mass spectrometry system to the Xevo TQ Absolute – improving performance, results, and productivity while controlling costs and mitigating compliance risk.</p><p><strong>*</strong>Availability of offerings varies by country. Contact Waters or your local Waters representative for details.</p><p><strong>** </strong>FlexCAPITAL payment plan options and availability may vary by country. Other restrictions may apply.</p>

Waters Xevo G3 QTof Mass Spectrometer

The Xevo™ G3 QTof, an analytical workhorse, is designed to characterize and quantify a diverse set of molecules.

<h3><strong>Complete Coverage for Confident Characterization</strong></h3><p><strong>The Xevo™ G3 QTof, an analytical workhorse, is designed to characterize and quantify a diverse set of molecules.</strong></p><h4><strong>ULTIMATE PERFORMANCE</strong></h4><p>Ensure maximum coverage of analytes and with improved transmission low m/z ions, labile species, while still excelling in <strong>traditional biopharmaceutical workflows</strong> and addressing emerging needs to <strong>characterize new modalities</strong>.</p><h4><strong>CONNECTED PRODUCTIVITY</strong></h4><p>Harmonize workflows across development, manufacturing and QC by deploying the <strong>Xevo G3 QTof</strong> and the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/289"><strong>BioAccord™ System</strong></a> with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/191"><strong>ACQUITY™ Premier</strong></a> within the waters_connect™ ecosystem.</p><h4><strong>EXTENDED FLEXIBILITY</strong></h4><p>Improved quantitative capabilities, with wider inter- and intra-spectrum dynamic range for comprehensive quantitative/qualitative analysis, ideal for screening and targeted applications.</p><h4><strong>UNQUESTIONED CONFIDENCE</strong></h4><p>Ensure high quality data with consistent robustness and reproducibility through advances in ion optics, maintaining performance and productivity over a longer time period.</p><h3><strong>Ultimate Performance</strong></h3><h4><strong>Increase your application coverage</strong></h4><p>As labs extend their capabilities, more is required from their analytical systems. The Xevo G3 QTof incorporates new technology building blocks that improve a scientists’ ability to characterize:</p><ol><li>Complex biologics with inclusion of a <strong>m/z 16,000 calibration range</strong> and <strong>tailored informatics</strong>.</li><li>Challenging small molecules with updates to the ion optics and detection system that <strong>maximize transmission and dynamic range</strong>.</li></ol><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_G3_Q_Tof_The_Xevo_G3_Q_Tof_equipped_with_the_Step_Wave_XS_ion_guide_efficiently_transmits_low_mz_ions_labile_species_increasing_compound_coverage_and_analytical_fidelity_73db146372.jpg" alt="Waters Xevo G3 QTof: The Xevo G3 QTof, equipped with the StepWave™ XS ion guide, efficiently transmits low mz ions, labile species, increasing compound coverage and analytical fidelity." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_G3_Q_Tof_The_Xevo_G3_Q_Tof_equipped_with_the_Step_Wave_XS_ion_guide_efficiently_transmits_low_mz_ions_labile_species_increasing_compound_coverage_and_analytical_fidelity_73db146372.jpg 234w," sizes="100vw" width="1024" height="682"></p><h3><strong>Connected Productivity</strong></h3><h4><strong>Harmonize your workflows across the pipeline</strong></h4><p>Harmonizing workflows across development, manufacturing and QC is key to ensuring lab productivity. The Xevo G3 QTof is ideal for <strong>characterizing biomolecules</strong> and processes before transitioning to dedicated attribute monitoring assays on either the Xevo G3 QTof or <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/289"><strong>BioAccord System</strong></a> with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/191"><strong>ACQUITY Premier</strong></a>.</p><p>The <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1544"><strong>waters_connect</strong></a><strong> </strong>Ecosystem offers seamless, compliant-ready workflows to understand and monitor biotherapeutic variation. Systems and users can be connected through waters_connect, with security-controlled access, full data traceability, with the operational efficiency and scalability of networked deployment.</p><p>Achieve robust and unbiased performance for analysis of your biotherapeutics with ACQUITY Premier Systems and Columns and an expanding array of informatics tools, including <strong>Peptide MAM</strong>, <strong>INTACT Mass</strong>, and <strong>CONFIRM Sequence</strong> applications.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_G3_Q_Tof_Harmonize_your_workflows_with_Xevo_G3_Q_Tof_the_Bio_Accord_System_and_tailored_informatics_f9cc61424f.jpg" alt="Waters Xevo G3 QTof: Harmonize your workflows with Xevo G3 QTof, the BioAccord System and tailored informatics." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_G3_Q_Tof_Harmonize_your_workflows_with_Xevo_G3_Q_Tof_the_Bio_Accord_System_and_tailored_informatics_f9cc61424f.jpg 237w," sizes="100vw" width="1024" height="674"></p><h3><strong>Delivering Qualitative and Quantitative Performance</strong></h3><h4><strong>Is it detected and how much is detected?</strong></h4><p>Analytical laboratories are under pressure to maximize system usage, so a flexible multifunctional instrument that can deliver high quality qualitative and quantitative data sets is critical.</p><p>The Xevo G3 QTof, has evolved to address those needs, with updates to core technology delivering <strong>up to 5 orders of linear dynamic range</strong> through application of adaptive intensity control for <strong>targeted Tof-MRM analysis</strong>.</p><p>For untargeted and screening experiments, with up to 4x increase in-spectrum dynamic range, the Xevo G3 QTof is able detect and quantify components of interest in the most challenging of complex matrices.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Corporation_Waters_Xevo_G3_Q_Tof_jako_instruemtnace_pro_ziskani_kvalitativnich_a_kvantitativnich_dat_daa8aa1ef4/Waters-Corporation-Waters-Xevo-G3-QTof-jako-instruemtnace-pro-ziskani-kvalitativnich-a-kvantitativnich-dat.webp" alt="Waters Xevo G3 QTof: Utilizing Tof-MRM to answer critical questions." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Corporation_Waters_Xevo_G3_Q_Tof_jako_instruemtnace_pro_ziskani_kvalitativnich_a_kvantitativnich_dat_daa8aa1ef4/thumbnail_Waters-Corporation-Waters-Xevo-G3-QTof-jako-instruemtnace-pro-ziskani-kvalitativnich-a-kvantitativnich-dat.webp 245w," sizes="100vw" width="984" height="497"></p><h3><strong>Complete Confidence</strong></h3><h3><strong>High quality reliable data sets every time</strong></h3><p>Instrument stability and uptime are unquestioned necessities in a fast-paced high-throughput environment. The evolved design of the Xevo G3 QTof has been engineered to deliver consistent robustness and reproducibility, maintaining performance and productivity over a longer time period. With updated ion optics and optimized ion beam conditioning the Xevo G3 QTof is a true analytical workhorse that deliverables high quality data routinely.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Corporation_Konstrukce_hmotnostniho_spektrometru_Xevo_G3_Q_Tof_10fbbd6639/Waters-Corporation-Konstrukce-hmotnostniho-spektrometru-Xevo-G3-QTof.webp" alt="Waters Xevo G3 QTof: The Xevo G3 QTof, equipped with the StepWave™ XS ion guide, efficiently transmits low m/z ions, labile species, increasing compound coverage and analytical fidelity." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Corporation_Konstrukce_hmotnostniho_spektrometru_Xevo_G3_Q_Tof_10fbbd6639/thumbnail_Waters-Corporation-Konstrukce-hmotnostniho-spektrometru-Xevo-G3-QTof.webp 175w," sizes="100vw" width="1695" height="1514"></p><h3><strong>Unhindered Analytical Capabilities</strong></h3><h4><strong>Extending the reach of characterization</strong></h4><p>Having an extensive toolkit at your disposal protects against future unknowns and the ever-increasing complexity of samples.</p><p>The Xevo G3 QTof is equipped with the universal source architecture, maximizing versatility and minimizing downtown. With options including<strong> ESI, ESCi,™ APCI, APGC,™ ASAP,™ UniSpray,™ nanoFlow ESI, </strong>and <strong>DESI XS*</strong> the Xevo G3 QTof can be used for many different applications and molecule types — swap your source not your instrument.</p><p>Support of a range of inlets including <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/191"><strong>ACQUITY Premier System</strong></a><strong>, ACQUITY UPLC™ PLUS Series, ACQUITY UPLC M-Class,</strong> and <strong>ACQUITY 2D-LC* </strong>ensures your lab is equipped for the future and can handle challenging and complex samples.&nbsp;<br><strong>* </strong>For specific configuration requirements consult with your Waters Representative.</p><p>The Xevo G3 QTof is available on both our <strong>waters_connect</strong> and <strong>MassLynx™ Software</strong> platforms, providing the ultimate flexibility to meet your labs analytical requirements.</p><p><strong>waters_connect: </strong>The modern, app-based software platform, waters_connect, offers seamless, compliant-ready workflows ensuring data traceability and transferability in a fast paced, highly connected laboratory.</p><p><strong>MassLynx:</strong> The well-established MassLynx Software package delivers market-leading versatility and flexibility for all application areas.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_G3_Q_Tof_Sequence_coverage_map_of_a_21mer_heavily_modified_oligonucleotide_within_the_CONFIRM_Sequence_application_displaying_all_the_confirmed_fragment_ions_4c7a8a75cf.jpg" alt="Waters Xevo G3 QTof: Sequence coverage map of a 21mer heavily modified oligonucleotide within the CONFIRM Sequence application, displaying all the confirmed fragment ions." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_G3_Q_Tof_Sequence_coverage_map_of_a_21mer_heavily_modified_oligonucleotide_within_the_CONFIRM_Sequence_application_displaying_all_the_confirmed_fragment_ions_4c7a8a75cf.jpg 235w," sizes="100vw" width="1237" height="822"></p>

Waters Empower Chromatography Data System (CDS)

Empower Chromatography Data System (CDS) has been intentionally designed to help you address your most rigorous chromatographic, regulatory, and networking challenges.

<div><div id="title-230ef9ecce" data-locator="title-with-text"><h3><strong>Elevate your chromatography with the universal language of the lab</strong></h3></div></div><div><div id="text-3b75bcd8fb" data-locator="text"><p><strong>Simplifying the way you collect, manage, and report chromatography test results is critical to your lab efficiency. With a suite of flexible functionalities that grows to meet your changing quality, business, and laboratory needs, Empower Chromatography Data System (CDS) has been intentionally designed to help you address your most rigorous chromatographic, regulatory, and networking challenges.</strong></p><p>Empower CDS<strong> </strong>helps your entire laboratory operate more efficiently and securely with the industry's most advanced data acquisition, management, processing, analytics, and reporting capabilities. Easily scalable from a single workstation to an enterprise-wide network, where you can work at the bench, across sites, and even remotely with on-premises or cloud options, Empower CDS provides an environment where your records are traceable, so you always have full control of your most critical asset - your data.</p><div><div id="text-8f4122209c" data-locator="text"><h3><strong>Overview</strong></h3><div data-locator="section-container-body"><div><div><div data-locator="layoutcontainer-"><div><div id="text-07744ba23e" data-locator="text"><ul><li><strong>Store and retrieve chromatography data using an embedded, relational database</strong>; simplifying data retrieval by searching with criteria that is meaningful to you</li><li><strong>Save time, reduce manual integration, and calculate more precise peak integrations</strong> with the ApexTrack algorithm in Empower CDS</li><li><strong>Easily control</strong> Waters high-performance liquid chromatography (HPLC), UHPLC, and UPLC systems, as well as non-Waters HPLC, gas chromatography (GC), photodiode array detector (PDA), and mass spectrometry (MS) systems</li><li><strong>Achieve more enhanced detection capabilities</strong> when using Waters mass detectors or the Waters ACQUITY UPLC PDA Detector</li><li><strong>Grow seamlessly from a single workstation to an enterprise-wide system</strong> with the scalable, modular architecture in Empower CDS, which fits into the most modern and secure high-availability corporate architecture</li><li><strong>Deploy applications</strong> such as dissolution, method validation, integrated chemical structures, and polymer or size exclusion analysis</li></ul></div></div><div><div id="text-a7790dd22b" data-locator="text"><h3><strong>Recommended Use</strong></h3><p>For advanced data acquisition, management, processing, reporting, and distribution of chromatography analysis data.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Empower_Chromatography_Data_System_CDS_Operate_more_efficiently_and_securely_with_the_flexible_capabilities_of_Empower_Chromatography_Data_System_CDS_9625ca12d5.jpg" alt="Waters Empower Chromatography Data System (CDS): Operate more efficiently and securely with the flexible capabilities of Empower Chromatography Data System (CDS)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Empower_Chromatography_Data_System_CDS_Operate_more_efficiently_and_securely_with_the_flexible_capabilities_of_Empower_Chromatography_Data_System_CDS_9625ca12d5.jpg 234w," sizes="100vw" width="1024" height="682"></p><div><div id="text-f39d8a00c0" data-locator="text"><h3 data-locator="modal-title"><strong>Interface options unique to your users</strong></h3><p>Empower Software represents a fundamental shift in <strong>UPLC/UHPLC, HPLC, and LC-MS</strong> system usability. It is equipped with unique interface options designed for your lab, regardless of the task or user's skill level. When users log in, they are presented with the application that provides the appropriate workflow for them. If authorized, users can select another software interface that is suitable for their current task.</p><h5><strong>The three Empower Software applications are:</strong></h5><ul><li><strong>QuickStart</strong>&nbsp;- Collect, process, and report data from a single-window access. Use a wizard to set up methods and run assays. Navigate the entire Empower environment from one screen, including instrument control, view plotted data in real time, view raw data, and access tools to customize and print reports.</li><li><strong>Pro</strong>&nbsp;- Access to all software functions for advanced users, system administrators, or anyone who needs total control.</li><li><strong>Open Access</strong>&nbsp;- Select your method and the number of samples you need to run and get started with the click of a mouse. No chromatography experience is necessary.</li></ul><figure class="image"><img style="aspect-ratio:1024/594;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Empower_Chromatography_Data_System_CDS_The_Empower_Quick_Start_interface_uses_a_navigation_bar_to_guide_you_through_the_software_and_all_tasks_are_carried_out_in_one_window_dfe3ec8bb7.jpg" alt="Waters Empower Chromatography Data System (CDS): The Empower QuickStart interface uses a navigation bar to guide you through the software and all tasks are carried out in one window." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Empower_Chromatography_Data_System_CDS_The_Empower_Quick_Start_interface_uses_a_navigation_bar_to_guide_you_through_the_software_and_all_tasks_are_carried_out_in_one_window_dfe3ec8bb7.jpg 245w," sizes="100vw" width="1024" height="594"></figure><div><div id="text-b65d021cbc" data-locator="text"><h3 data-locator="modal-title"><strong>Ideal for data analysis</strong></h3><h5><strong>Improve data analysis workflows and information sharing across your lab with Empower Software, which helps you achieve:</strong></h5><ul><li><strong>Reliable shoulder peak detection</strong> - ApexTrack effectively detects and integrates shouldered peaks, providing more reliable detection of low-level peaks on noisy or sloping baselines for less manual manipulation and more accurate results.</li><li><strong>Automated custom calculations</strong> - Simply use a wizard to set up your parameters, like averages or % relative standard deviation (RSD). After configuring the calculation once, Empower Software automatically determines the answer when data is processed - no more data transfer, spreadsheet manipulation, or transfer errors.&nbsp;</li><li><strong>Better information sharing </strong>- Easily share information with colleagues worldwide with results and reports stored within the same database. Create combined summary reports across laboratories, instruments, and projects, regardless of where data was acquired or processed. Create PDFs or email reports, distribute methods and information electronically, access information between remote sites, and review and electronically sign off results.</li><li><strong>Fast access to information </strong>- Empower CDS has an embedded relational database, enabling you to store chromatographic results, automatically linking all metadata without manual information tracking or documentation, and better preparing you for review questions or audits. Find data fast and easily with relevant search terms and automatic time stamps of user activity - without a flat file environment, awkward naming conventions, or manual method and result versioning.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Empower_Chromatography_Data_System_CDS_9a791332d9.jpg" alt="Waters Empower Chromatography Data System (CDS): As an example of the breadth of technology that Empower offers, the software can control mass spectrometry (MS) instruments and acquire and process MS data. Spectral information from multiple detection modes can be viewed simultaneously. This enables scientists to easily perform complex analyses with minimal training, increasing lab productivity." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Empower_Chromatography_Data_System_CDS_9a791332d9.jpg 245w," sizes="100vw" width="1024" height="553"></p><div><div id="text-a10f03a0ca" data-locator="text"><h3 data-locator="modal-title"><strong>At-a-glance key chromatography data views to maximize lab resources</strong></h3><p>Empower Laboratory Analytics assembles and displays critical chromatography performance data in easy-to-view, graphical dashboards so you can focus on what’s most important―the interpretation of key information, not its collection.&nbsp;</p><p>Empower Laboratory Analytics offers a range of prebuilt dashboard types, including system summary, system usage, project usage analysis, and methods analysis. These at-a-glance dashboards let you quickly and accurately determine how laboratory resources are being used, without significant manual effort. With these dashboards, you can make evidence-based decisions on which improvements are needed to increase laboratory efficiency.&nbsp;</p><p>With Empower Laboratory Analytics, you can maximize system utilization and better manage resources. You can quickly identify training needs, error messages affecting workflows, and non-robust processing methods. With Empower Software, your lab can better plan for capital expenditures and identify opportunities to shorten run times with UPLC/UHPLC technology.</p></div></div><div><div id="text-497ef11ba3" data-locator="text"><h3 data-locator="modal-title"><strong>Monitor your chromatography system anytime, anywhere</strong></h3><h5><strong>Empower Mobile gives you wireless access to Empower Software from a tablet or smartphone, making it easier to know what’s happening in your laboratory no matter where you are to:</strong></h5><ul><li>Improve laboratory efficiency</li><li>Easily find and share results remotely</li><li>Expedite workflow for signoff on reports</li><li>Lower operating costs for system administration tasks</li><li>Reduce sample and mobile phase waste</li></ul><p>Whether you are an analyst, manager, or system administrator, this easy-to-use application, specially designed to run on mobile devices, gives you the flexibility to work on other priorities, knowing that you can use your mobile device at any time to monitor system status, perform routine system administration tasks, and review and sign off reports.</p><p>Empower Mobile is versatile and has been optimized to work with Apple iPad and iPhone and Android tablet and smartphone devices. Empower Mobile can be installed on your Empower Software network in either workgroup or enterprise configurations, all at no additional cost to you.&nbsp;</p><div><div id="text-8f9e5e7bd5" data-locator="text"><blockquote><h3><strong>Empower 3.9.0 is here</strong></h3><h5><strong>Keep your lab current with the latest Empower Software release built to enhance efficiency, productivity, and compliance readiness so you can drive better scientific and business outcomes across your organization.</strong></h5><h4><strong>With Empower 3.9.0 you can:</strong></h4><ul><li><strong>Reduce risk: </strong>Full Windows® 11 support to keep your data safe with the latest Microsoft® updates.</li><li><strong>Increase efficiency: </strong>Updates in the Review window simplify work for users when workflows require technical controls to reduce the potential for human bias.</li><li><strong>Reduce cost and effort: </strong>New Empower RapidDeploy Software option for LAC/E devices reduces the effort spent planning, preparing, and coordinating LAC/E device upgrades and significantly reduces resource constraints often encountered during upgrades — reducing upgrade costs and minimizing downtime during upgrades so you can&nbsp;keep your operations current.</li></ul><h4><a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/nextgen/us/en/services/software-services/software-upgrades/empower-software-upgrade-request.html"><strong>Upgrade to the latest version!</strong></a></h4></blockquote></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Waters MassLynx Mass Spectrometry Software

With development largely driven by input from our extensive user base, MassLynx provides the fundamental platform to acquire, analyze, manage, and share mass spectrometry information.

<h3><strong>Our well-established MassLynx software package delivers market-leading versatility and flexibility for all application areas.</strong>&nbsp;</h3><div><div id="text-f93532e53f" data-locator="text"><p><strong>MassLynx was first pioneered to simplify interaction with mass spectrometry (MS) and has continually improved to meet changing customer needs. The result: a market-leading software solution that allows users to best leverage their MS system and harness real-time intelligence, ensure MS system performance, and more quickly convert sample data into valuable knowledge. With development largely driven by input from our extensive user base, MassLynx provides the fundamental platform to acquire, analyze, manage, and share mass spectrometry information.</strong></p><p>MassLynx Software features a <strong>21 CFR Part 11-compatible security</strong> including <strong>file encryption, audit log</strong>, and <strong>secure archival/retrieval technology</strong> with flexible security policies to meet your lab requirements. Waters also offers excellent <a target="_blank" rel="noopener noreferrer" href="https://www.waters.com/waters/nav.htm?cid=1000349" data-di-id="di-id-5aca7e0f-b105e917"><strong>service and suppor</strong>t</a> to get the system up and running – for on-time results without the stress.</p><h2><strong>MassLynx Quantitation Applications</strong></h2><div><div id="title-eb2a5ffa29" data-locator="title-with-text"><h4><strong>Streamline quantitative data acquisition and processing</strong></h4></div></div><div><div id="text-baefaeaec6" data-locator="text"><p>The rate determining step in many analyses is not data acquisition, but the speed your data can be converted into useful information.</p><p>To assist you with both application-specific data acquisition and the transformation of data into usable results, MassLynx for quantitation offers a range of <strong>application managers</strong> with specialized data processing functionalities, which eliminates the need for complex time-consuming manual data review, increasing your productivity.</p><p>The functionality of <strong>MassLynx application managers</strong> has been guided by our customers and optimized for your data analysis and processing requirements.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Mass_Lynx_Quantitation_Applications_b5a284165b.jpg" alt="Waters: MassLynx Quantitation Applications." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Mass_Lynx_Quantitation_Applications_b5a284165b.jpg 245w," sizes="100vw" width="1428" height="625"></p><h3><strong>Overview</strong></h3><div data-locator="section-container-body"><div><div><div data-locator="layoutcontainer-"><div><div id="text-4b29255c4a" data-locator="text"><ul><li>A tried and well-established software package, MassLynx delivers the versatility and flexibility you require for all of your quantitation applications</li><li>MassLynx security system provides compliance ready tools to meet GxP and 21 CFR Part 11 regulations and TargetLynx XS delivers the information necessary for regulatory compliance</li><li>Inlet method editor and MS method editor allow the user to intuitively build LC-MS/MS methods for quantitative data acquisition</li><li>Auto-dwell for MRM dwell times makes it easy to optimize MRM methods to maximize points per peak and get the best quantitative performance</li><li>IntelliStart guarantees maximum system performance and usability for reproducible results</li></ul></div></div><div><div id="text-adc477d45b" data-locator="text"><h3><strong>Recommended Use</strong></h3><p>MassLynx quantitation applications streamline quantitative data acquisition and processing.</p><div><div id="title-be02784995" data-locator="title-with-text"><h2><strong>MassLynx Mass Detection Applications</strong></h2></div></div><div><div id="title-d5b484d548" data-locator="title-with-text"><h4><strong>Intuitively interact with your mass detection system with MassLynx</strong></h4></div></div><div><div id="text-0fc50dc8ea" data-locator="text"><p>The challenges of mass spectrometry (MS) analyses are often compounded by the use of several types of analytical instruments and high personnel turnover. To maintain and even increase laboratory productivity and efficiency, MassLynx Software simplifies interaction with your mass detection system. MassLynx enables users with a wide range of expertise to easily acquire high-quality mass spectral data with minimal training.</p><p>MassLynx application managers enable you to focus the power of MS on your laboratory's tasks.</p><h3><strong>Overview</strong></h3><div data-locator="section-container-body"><div><div><div data-locator="layoutcontainer-"><div><div id="text-fb3c291dd5" data-locator="text"><ul><li>MassLynx delivers the versatility and flexibility you require for all of your mass detection applications</li><li>Easy-to-use application managers enable you to simply transform mass spectral data into usable results</li><li>Intuitive setup and interaction with the mass detector guarantees optimal performance and reproducible results</li><li>Routinely using the same intuitive software provides familiarity and simplicity for more efficient workflows</li><li>Inlet method editor and MS method editor allow the user to intuitively build LC-MS methods for qualitative and quantitative data acquisition</li></ul></div></div><div><div id="text-4b89cfd965" data-locator="text"><h3><strong>Recommended Use</strong></h3><p>Masslynx Application Managers enable laboratories to confidently produce high quality results without complexity.</p><p><img style="aspect-ratio:1086/319;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Mass_Lynx_Mass_Detection_Applications_f261c2afd6.jpg" alt="Waters: MassLynx Mass Detection Applications." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Mass_Lynx_Mass_Detection_Applications_f261c2afd6.jpg 245w," sizes="100vw" width="1086" height="319"></p><div><div id="title-67851c4cd4" data-locator="title-with-text"><h2><strong>MassLynx High-Resolution Applications&nbsp;</strong></h2></div></div><div><div id="title-1688118c0d" data-locator="title-with-text"><h4><strong>Fully characterize your samples with Waters high-resolution mass spectrometry</strong></h4></div></div><div><div id="text-fc7cb897e2" data-locator="text"><p>As the power of high-resolution mass spectrometry (HRMS) allows today’s labs to obtain high quality data, the challenge is then to confidently identify and characterize components of interest.</p><p>Waters MassLynx Applications enable your lab to efficiently process and interpret HRMS data sets – whether your samples are biological, chemical, environmental, or pharmaceutical, we have a solution that meet your needs, whether it's based on gas chromatography (GC-MS) or liquid chromatography mass spectrometry (LC-MS).</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Mass_Lynx_High_Resolution_Applications_9811f2e6b9.jpg" alt="Waters: MassLynx High-Resolution Applications." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Mass_Lynx_High_Resolution_Applications_9811f2e6b9.jpg 245w," sizes="100vw" width="1422" height="594"></p><h3><strong>Overview</strong></h3><div data-locator="section-container-body"><div><div><div data-locator="layoutcontainer-"><div><div id="text-b16ee61766" data-locator="text"><ul><li>Rapidly identify metabolites with MetaboLynx XS</li><li>Achieve confident structural elucidation with MassFragment</li><li>Automate the processing of LC-MS, GC-MS, LC-MS/MS, or GC-MS/MS data with ChromaLynx</li><li>Meet quantitative and qualitative proteomics research requirements with ProteinLynx Global Server (PLGS)</li></ul></div></div><div><div id="text-1dee9a4274" data-locator="text"><h3><strong>Recommended Use&nbsp;</strong></h3><p>For identifying and characterizing data acquired using high-resolution mass spectrometry.</p></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Waters Alliance iS HPLC System

Waters™ delivers a reliable partner for QC labs. The Alliance™ iS HPLC System enhances efficiency, reduces errors, and simplifies workflows - your new essential lab ally.

<h3><strong>The Alliance iS HPLC System didn’t start in our lab.</strong></h3><p class="cke-user_style-important"><strong>It started in yours.</strong></p><p><strong>Pharmaceutical Quality Control (QC)</strong> labs face relentless demand to <strong>do more with less</strong> amid higher staff turnover, growing levels of sample complexity, and the drive to reduce errors.</p><p>With regulatory scrutiny and faster time to market fueling these intense demands, the need for <strong>simplicity has never been greater</strong>.</p><p>Waters™ understands the challenges you face and is ready to deliver a true ally for your laboratory. With capabilities developed specifically for the QC laboratory, the <strong>Alliance™ iS HPLC System</strong> will quickly become your favorite ally.</p><ul style="list-style-type:disc;"><li>Intuitively prevents up to 40% of common errors*</li><li>Provides fast, simple guidance at the point of need</li><li>Boosts productivity and capacity through effective resource utilization and error-free operation</li><li>Drives workflow efficiencies and quality improvements</li><li>Improves data integrity</li></ul><p>*Based on Waters’ market research in 2022, surveying 56 global Pharma QC labs running &gt;25 systems</p><h3><strong>Common challenges facing the QC lab</strong></h3><p class="cke-user_style-important"><strong>What you are telling us</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_i_S_HPLC_System_cc30c5f925.jpg" alt="Waters Alliance iS HPLC System - What you are telling us" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_i_S_HPLC_System_cc30c5f925.jpg 245w," sizes="100vw" width="2038" height="1132"></p><h3><strong>Meet your new lab ally</strong></h3><p>Intuitive and reliable, the <strong>Alliance iS HPLC System</strong> is designed to work seamlessly with <strong>Empower™ Software</strong> and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720007883en_41b7055d98/720007883en.pdf"><strong>eConnect™ Column Tag Technology</strong></a>, unlocking unique features and functionality that eliminate the need to choose between simplicity, efficiency, and quality.</p><h3><strong>Step-change the performance of your lab</strong></h3><p class="cke-user_style-important"><strong>Achieve First Time Quality (FTQ) with the Alliance iS HPLC System</strong></p><p>The <strong>Alliance iS HPLC System</strong> supports FTQ by reducing the risk of common errors and improving the reliability of analytical measurements. Your lab can <strong>reduce reagents and consumables waste</strong>, and automated system checks help to meet critical error reduction KPIs. The increase in operational efficiency and productivity will save time and money and boost the capacity of your lab.**</p><p>With ease of use at the heart of the user experience, the <strong>Alliance iS HPLC System</strong> identifies potential errors earlier, reducing the number of retests and failure investigations. This supports a Quality culture resulting not only in safer products critical to human health and well-being, but also an improved working environment, directly impacting employee retention and motivation.**</p><p>**vs the Alliance HPLC System</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_i_S_HPLC_System_2_44577b6737.jpg" alt="Waters Alliance iS HPLC System with bottles connected." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_i_S_HPLC_System_2_44577b6737.jpg 234w," sizes="100vw" width="1024" height="682"></p><h3><strong>The System: intuitively simple</strong></h3><h5><strong>System Status Lighting and Solvent Tubing Clips&nbsp;</strong></h5><p>Status lighting provides you with a clear visual indication of the system status (in use, idle etc), while the color-coded solvent tubing clips ensure the tubing remains organized to enable tracing from instrument to the solvent bottle flags.</p><h5><strong>Made for Empower</strong></h5><p><strong>Waters Empower Software Suite</strong> helps your entire laboratory operate better, with the industry’s most advanced data acquisition, management, processing, analytics, and reporting capabilities. Empower Software provides you an environment where your records are traceable, so you always have full control of your most critical asset - your data.</p><h5><strong>waters_connect™ System Monitoring&nbsp;</strong></h5><p>Maximize lab productivity - utilize resources more effectively with real-time lab management from anywhere, anytime. System Monitoring provides intuitive and centralized access to detailed Empower Software instrument information via the waters_connect Cloud Platform, without compromising security or compliance.</p><h5><strong>Intelligent Method Translator App&nbsp;</strong></h5><p>Working with Empower Software, the iMTA enables you to create an Alliance iS HPLC System Instrument Method directly from a Waters or other third-party LC system. Basic chromatographic conditions are automatically transferred for you, and the new Empower instrument method can be reported, providing traceability to the original method for compliance.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_i_S_HPLC_System_with_bottles_connected_and_the_doors_open_ff4184918a.jpg" alt="Waters Alliance iS HPLC System with bottles connected and the doors open." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_i_S_HPLC_System_with_bottles_connected_and_the_doors_open_ff4184918a.jpg 234w," sizes="100vw" width="1024" height="682"></p><h3><strong>Say ‘hi’ to your lab ally</strong></h3><h5><strong>Intuitive touchscreen&nbsp;</strong></h5><p>An easy-to-use, advanced touchscreen integrates with Empower Software and provides easy-to-follow steps. Pre-run checks for common errors such as missing vials, incorrect column, and qualification/preventative maintenance requirements enable you to catch these mistakes before they result in a sample analysis failure, preventing re-runs.</p><h5><strong>Help at your fingertips&nbsp;</strong></h5><p>The Alliance iS HPLC System support journey delivers smart on-board technology that digitally brings you straight to the information you need at the new Waters Help Center. Train and troubleshoot with ease, knowing that Waters will support you at every stage.</p><h5><strong>Smart column capabilities&nbsp;</strong></h5><p>Ensure complete column traceability and facilitate post-run troubleshooting with the eConnect HPLC Columns. Ready-to-use from the box, eConnect columns are securely fitted with an NFC-enabled eConnect device tag, ensuring they are always automatically identified, verified, and tracked by the system. These second-generation smart columns propel today’s QC laboratory toward an entirely digital platform and away from manual logbooks.</p><h3><strong>Enjoy stress-free analysis</strong></h3><p>The Alliance iS HPLC System keeps you and your lab stress-free and running smoothly with an intuitive touchscreen that supports the productivity and efficiency of your lab.</p><ul><li>Start your day easily with a system guided start-up.</li><li>Pre-run checks to minimize sample analysis failures due to human error.</li><li>When issues arise, Alliance iS HPLC System provides you with information about what needs attention.</li><li>Guided workflows provide step-by-step guidance on how to resolve common issues.</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_i_S_HPLC_System_2_0e64835283.jpg" alt="Waters Alliance iS HPLC System - Enjoy stress-free analysis." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_i_S_HPLC_System_2_0e64835283.jpg 204w," sizes="100vw" width="1388" height="1063"></p><h3><strong>Built to perform, time after time</strong></h3><h4><strong>Intuitive innovation</strong></h4><p>Developed with the singular goal of providing innovation that solves the problems that matter in the QC lab, the Alliance iS HPLC System includes a range of new and unique features.&nbsp;</p><ul><li>New electronics to enable the Alliance iS HPLC System smart features (including advanced touchscreen, eConnect Column Tag Technology, and unparalleled interactivity with Empower Software)</li><li>Redesigned check valves and mixer for increased performance and robustness</li><li>Faster detector warm-up time and reduced drift to ensure you’re up and running quickly, for as long as your analysis requires</li><li>Robust performance when operating at the extremes of the Column Heater Cooler and Sample Manager temperature ranges</li><li>Class leading carryover performance and injection precision</li></ul><figure class="image"><img style="aspect-ratio:1561/740;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_i_S_HPLC_System_3_9aab20fd13.jpg" alt="Waters Alliance iS HPLC System - Overlay of 42 injections of gradient performance mix over 44 hours demonstrated RT repeatability of 0.5% RSD on the Alliance iS HPLC System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_i_S_HPLC_System_3_9aab20fd13.jpg 245w," sizes="100vw" width="1561" height="740"></figure><h3><strong>Alliance iS HPLC System gives you so much more</strong></h3><p class="cke-user_style-important"><strong>Unlock new potential with Empower Software</strong></p><p><strong>The Alliance iS HPLC System works exclusively with our </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/labrulez-bucket-strapi-h3hsga3/720008057en_af76145fe7/720008057en.pdf"><strong>Empower Software</strong></a><strong> version 3 Feature Release 4 </strong>or later, with fully enabled and differentiated features, starting with eConnect Technology. Empower Software elevates your quality, your business, and your lab.</p><ul style="list-style-type:disc;"><li>Intuitive method matching</li><li>Bi-directional touchscreen interactivity</li><li>Column tracking and history</li><li>Enhanced instrument traceability</li><li>Pre-run checks</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_i_S_HPLC_System_4_430a084194.jpg" alt="Waters Alliance iS HPLC System gives you so much more." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_i_S_HPLC_System_4_430a084194.jpg 245w," sizes="100vw" width="1385" height="674"></p><h3><strong>Help at your fingertips</strong></h3><p class="cke-user_style-important"><strong>From onscreen to onsite, we’re there for you.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Alliance_i_S_HPLC_System_5_df4f1467ed.jpg" alt="Waters Alliance iS HPLC System - From onscreen to onsite, we’re there for you." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Alliance_i_S_HPLC_System_5_df4f1467ed.jpg 245w," sizes="100vw" width="1550" height="910"></p><p>Maintain peak performance, minimize unexpected downtime, and ensure regulatory compliance of your AllianceTM iS HPLC System by partnering with Waters Service. Waters FlexCHOICETM Full-Service Plan for Regulated Laboratories includes:</p><ul style="list-style-type:disc;"><li>Yearly Waters Performance Maintenance</li><li>Priority* remote and onsite service including all parts, labor and travel</li><li>Full suite of compliance services</li><li>Discounts on future hardware upgrades and user training</li><li>Optional coverage available:<ul><li>Additional Performance Maintenance visits</li><li>Two business day on-site response time**</li></ul></li></ul><p>Priority over non-contract customers **May not be available in all areas</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_first_system_designed_for_Empower_the_Alliance_i_S_HPLC_System_features_intuitive_simplicity_built_specifically_for_QC_laboratories_112259fad6.jpg" alt="Waters Alliance iS HPLC System - The first system designed for Empower, the Alliance iS HPLC System features intuitive simplicity built specifically for QC laboratories." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_first_system_designed_for_Empower_the_Alliance_i_S_HPLC_System_features_intuitive_simplicity_built_specifically_for_QC_laboratories_112259fad6.jpg 234w," sizes="100vw" width="1024" height="682"></p>

Products distributed by Waters Corporation (Europe) - page 7

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