<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezGCMS Library in the week of 31st August 2026? Check out new documents from the field of the gas phase, especially GC and GC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT GCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies</strong>, <strong>Shimadzu, Thermo Fisher Scientific </strong>and presentation by<strong> MDCW / Liège University!</strong></p><h3><strong>1. Agilent Technologies: Extend the time window for the detection of low level anabolic‑androgenic steroids and their metabolites</strong></h3><p><strong>Steroid profiling, screening, and confirmatory analysis using the </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=10&amp;search=7010"><strong>Agilent&nbsp;7010 GC/MS mass spectrometer</strong></a></p><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/5991_9045_EN_Doping_Control_App_Note_1_13dde5f053.pdf"><strong>Full PDF for download</strong></a></li></ul><section><div><div><div><div><div><div><p>Doping laboratories want to have lower detection limits to be able to identify and quantitate illegal drugs for a longer time window between doping and urine sample collection. This Application Note describes how the doping control lab in Kreischa, Germany used the Agilent 7010 Triple Quadrupole GC/MS System (TQ) for enhanced targeted detection of anabolic‑androgenic steroids in urine samples. The 7010 TQ enabled higher sensitivity, longer maintenance-free intervals, and more stable operation than earlier models, and satisfied all measurement specifications required by the World Anti‑Doping Agency (WADA). The 7010 TQ GC/MS ion source produces more ions, and provides exceptional sensitivity for the detection of low intensity metabolites weeks after drug ingestion. However, this higher sensitivity may lead to saturation of endogenous components naturally present at higher concentrations. This method provides a sensitive and robust operation over a wide concentration range, permitting the detection of low-concentration exogenous species in the presence of high‑concentration endogenous species, which can vary with ethnicity.</p><h4><strong>Experimental</strong></h4><p>The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=10&amp;search=7010"><strong>Agilent 7010 GC/TQ system</strong></a> consists of an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=10&amp;search=7890"><strong>Agilent 7890 GC</strong></a> with multimode inlet and backflush, an<strong> Agilent 7993A</strong>, and the Agilent 7010 TQ mass spectrometer.</p><h4><strong>Conclusions&nbsp;</strong></h4><p>Based on the method optimization and thorough testing at the Kreischa lab, an Agilent 7010 GC/MS-based protocol was developed. This protocol fulfills the screening and confirmation requirements of steroid measurements in doping control labs. With this method, it is possible to detect traces of exogenous anabolic steroid metabolites while quantifying small concentrations of testosterone and epitestosterone typical in Asian populations. It permits the measurement of high‑abundance endogenous steroids such as androsterone and etiocholanolone in the same injection, while analyzing testosterone/epitestosterone and androsterone/etiocholanolone ratios without suppression.&nbsp;</p><p>The backflush capability of the system protects the analytical column, and consequently the mass spectrometer, by removing heavy matrix components. This allowed more than 6,000 samples to be analyzed on the same column without requiring ion source cleaning or filament change. It also demonstrated that the higher, 130&nbsp;eV electron energy did not sacrifice the filament lifetime. It performed reliable measurements of both trace (0.2&nbsp;pg on‑column) and high (10,000&nbsp;pg on‑column) concentration analytes in the same run.&nbsp;</p><p>The method validation revealed that the exceptional sensitivity offered by the 7010 GC/MS can be used to:&nbsp;</p><ul><li>Improve the trace detection ability of the method&nbsp;</li><li>Reduce the amount of sample&nbsp;injected&nbsp;</li><li>Extend maintenance-free intervals</li></ul><h3><strong>2. MDCW / Liège University: The Century Mix: updates and cool projects</strong></h3><ul><li>Presentation</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/DG_1_Dimandja_Stefanuto_34c4a66c3d.pdf"><strong>Full PDF for download</strong></a></li></ul><section><div><div><div><div><div><div><p>The presentation <strong>“The Century Mix: updates and cool projects”</strong> introduces the Century Mix, a standardized reference mixture developed for comprehensive two-dimensional gas chromatography (GC×GC). The mixture contains <strong>100 compounds representing a broad range of chemical classes</strong>, including alkanes, alcohols, ketones, esters, lactones, phthalates, and aromatic compounds. Stability was a key criterion in compound selection, and the mixture was developed through cross-laboratory collaboration for <strong>column characterization, method assessment, and quality control</strong>. Its structured chromatographic behavior also makes it useful for studying how different compound classes behave in GC×GC separations.</p><p>A major part of the work examined the <strong>factors influencing retention indices (RI) in GC×GC systems</strong>, which are important for reliable compound annotation in non-targeted analysis. An inter-laboratory study involved <strong>11 GC×GC systems</strong> using cryogenic, Peltier, and flow modulation, different detectors, and both normal and reversed column configurations. Principal component analysis showed clear grouping according to normal versus reversed orthogonality, confirming the strong influence of stationary-phase configuration. A subsequent design-of-experiments study evaluated <strong>140 combinations</strong> of temperature ramp rate, carrier-gas flow rate, modulation period, and secondary-oven temperature offset.</p><p>The results showed that the influence of experimental conditions is strongly <strong>compound dependent</strong>. Of the compounds evaluated in the statistical model, 33 showed RI variation that could be linked to the investigated parameters, whereas 43 did not follow the model well. Compounds such as quinoline, phthalates, lactones, terpenes, and some aromatic compounds showed particularly pronounced effects. For quinoline, for example, the model explained about <strong>93% of RI variability</strong>, with differences of approximately 75 RI units across the tested conditions, while 2-hexanone showed considerably weaker dependence. Overall, <strong>temperature ramp rate and flow rate emerged as particularly important parameters</strong>, although the magnitude of their effect depended on compound chemistry and column configuration.</p><p>The Century Mix is therefore being developed not only as a characterization mixture but also as a tool for <strong>system quality control and more reliable retention-index prediction</strong>. Repeated standardized QC measurements demonstrated very low RI variability and can be used to monitor system stability, experimental effects, and potential instrument drift. The broader goal is to better understand the fundamental chemistry governing GC×GC retention and ultimately improve method development, data processing, and identification of unknown compounds by combining high-quality separations, mass spectra, and predicted retention information.</p><h3><strong>3. Shimadzu: Determination of Free and Total Glycerol and Mono-, Di-, and Triglyceride Contents in Biodiesel According to EN 14105</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_05_sca_180_055_en_9b8677ed6a.pdf"><strong>Full PDF for download</strong></a></li></ul><h4><strong>User benefits</strong></h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=1&amp;search=2060"><strong>Nexis GC-2060</strong></a> offers reliable analysis of biodiesel samples regarding their free and total glycerol and mono-, di-, and triglyceride contents, using hydrogen as a cost-effective carrier gas&nbsp;</li><li>Hydrogen carrier gas can be used safely through built-in safety measures</li><li>The multi-mode injection unit (MMI) allows selection of the preferred injection mode – direct (simple OCI) or convenient splitless PTV mode – both delivering excellent instrument performance in line with the standard’s requirements</li></ul><p>Playing a vital part in countries’ efforts to lower greenhouse gas emissions, biofuels can be manufactured from various feedstocks such as vegetable oils, animal-derived fats, and recycled cooking oils. Biodiesel production predominantly uses rapeseed, soybean, and palm oils. Because feedstocks are so varied, ongoing quality monitoring is essential - since the raw material’s quality greatly influencesthe final biodiesel quality.&nbsp;</p><p>The EN 14105:2024 describes the determination of free and total glycerol contents and mono-, di-, and triglyceride contents in biodiesel by means of gas chromatography with flame ionization detection (GC-FID). Injection shall be performed via on-column injector or an equivalent device<sup>1</sup>.&nbsp;</p><p>This study shows the analysis of biodiesel originating from rapeseed, soybean, and palm oil using the Nexis GC-2060 gas chromatograph and its multi-mode injection unit (MMI).</p><h4><strong>Configuration and Analysis Conditions</strong></h4><p>Gas chromatograph <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=1&amp;search=2060"><strong>Nexis GC-2060</strong></a> with multi-mode injection unit (MMI), flame-ionization detector (FID) and autosampler <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/gcms/library?mainauthorItems=1&amp;search=AOC+-30i"><strong>AOC -30i</strong></a>.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>Nexis and AOC are trademarks of Shimadzu Corporation or its affiliated companies in Japan and/or other countries.. Nexis GC-2060 provides reliable analysis of biodiesel samples for glycerol and glyceride contents according to EN 14105:2024 across the commonly used feedstocks. It supports hydrogen as a cost-effective carrier gas, while the multi-mode injection unit (MMI) offers selection of the injection mode based on user preference: direct mode representing simple on-column (OCI) analysis or splitless programmed temperature vaporization (PTV) mode as a convenient alternative that delivers comparable performance.</p><h3><strong>4. Thermo Fisher Scientific: Streamlined static headspace GC–MS approach for detection of impurities in recycled PET</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_004458_gc_ms_impurities_recycled_pet_an004458_na_en_6cb2435671.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Polyethylene terephthalate (PET) is a widely used thermoplastic polymer valued for its strength, low weight, durability, and adaptability. Owing to these properties, it is extensively applied in packaging, textile fibers, and electronic components. PET is particularly suitable for recycling because it can be melted and reshaped multiple times with minimal loss of performance, and it is easily recognizable by the recycling code “1” (♳). The recycling of PET involves several stages, including collection, sorting, transport, processing, washing, pelletizing, and remanufacturing into new products [1]. However, during these steps, contaminants such as plasticizers, residual monomers, and degradation byproducts may be introduced.&nbsp;</p><p>The presence of such substances can pose potential risks to both environmental and human health, making the identification and characterization of contaminants in recycled PET essential for evaluating material quality and safety. Among the non-intentionally added substances (NIAS), benzene, acetaldehyde, and limonene are of particular relevance. Benzene is a recognized carcinogen and represents a serious health concern if present in PET. It may form as a degradation product of PET, with the reaction catalyzed by acidic compounds released at high temperatures by polymer impurities such as polyvinyl chloride (PVC). Poor temperature control or overheating can increase benzene formation as a degradation byproduct. Acetaldehyde, another degradation product of PET generated during bottle manufacturing, can alter the sensory properties of bottled beverages. Limonene, a flavor compound commonly present in soft drinks, may be absorbed into recycled PET and subsequently migrate into packaged beverages, potentially affecting product quality.&nbsp;</p><p>Gas chromatography coupled to headspace sampling is a fast and simple technique that enables the extraction of volatile and semivolatile compounds from solid and liquid samples without the need for time-consuming sample preparation.&nbsp;</p><p>In this study, headspace sampling coupled to single quadrupole mass spectrometry was used to assess the overall quantitative performance for analysis of acetaldehyde, benzene, and limonene in recycled PET packaging.&nbsp;</p><p>The capability of the Thermo Scientific™ ISQ™ 7610 single quadrupole GC–MS of combining the simultaneous acquisition of both single ion monitoring (SIM) and full scan (FS) allowed for sensitive targeted analysis as well as screening of unknown contaminants possibly present in recycled PET bottles.</p><h4><strong>Experimental&nbsp;</strong></h4><p>In all experiments, a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/64"><strong>TriPlus 500 HS autosampler</strong></a> was coupled to a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/486"><strong>Thermo Scientific™ TRACE™ 1610 Gas Chromatograph (GC)</strong></a>, configured with a Thermo Scientific™ iConnect™ Split/splitless Injector Module (iConnect-SSL), and connected to an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/484"><strong>ISQ 7610 single quadrupole mass spectrometer</strong></a>.&nbsp;</p><p>The separation of the target analytes was achieved using a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1751"><strong>Thermo Scientific™ Trace GOLD™ TG-624 SILMS capillary column</strong></a>, 60 m x 0.25 mm x 1.4 µm (Part No. 26059-3330). This column provides a low to mid polarity phase with high thermal stability (maximum operating temperatures up to 320 °C) and high inertness, enabling Gaussian peak shapes for analysis of volatile organics. The TriPlus 500 HS autosampler is connected directly to the analytical column, removing the use of a long external transfer line. In this configuration, the SSL injector module is used only for the pneumatic control of the carrier gas and split flow.</p><h4><strong>Conclusions&nbsp;</strong></h4><p>The results presented in this work demonstrate that headspace coupled to GC–MS provides a suitable and simple solution for analysis of contaminants in rPET, with no complex sample preparation required.&nbsp;</p><ul><li>The capability of combining FS with SIM acquisition allows for qualitative and quantitative analysis, increasing confidence in compound identification through spectral comparison with NIST library and allowing for the detection of possible analyte co-elution.&nbsp;</li><li>The TriPlus 500 HS autosampler provides highly repeatable solventless extraction from solid samples with absolute area counts RSD &lt; 5%, permitting reliable and consistent quantitative data.&nbsp;</li><li>The ISQ 7610 single quadrupole GC–MS demonstrates an extended linear response (≥ 4–5 orders of magnitude) with R2 ≥ 0.997, calculated amounts within ± 20% the expected value, and ion ratio deviation ≤ 15% across the calibration curve.&nbsp;</li><li>Sensitivity was demonstrated with overall calculated LOD ≤ 0.03 ng/µL.</li><li>Chromeleon CDS helps ensure data integrity, traceability, and effective data management from instrument control to the final report streamlining analysis and data review processes.</li></ul></div></div></div></div></div></div></section></div></div></div></div></div></div></section>

News from LabRulezGCMS Library - Week 36, 2026

News from LabRulezLCMS Library - Week 36, 2026

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 31st August 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring you brochures by <strong>Agilent Technologies </strong>and<strong> Waters Corporation </strong>and application notes by <strong>Shimadzu </strong>and<strong> Thermo Fisher Scientific!</strong></p><h3><strong>1. Agilent Technologies: Agilent OpenLab ICP-MS Software</strong></h3><p><strong>Simplify every step of ICP-MS analysis</strong></p><p><strong>For Agilent </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=7800"><strong>7800</strong></a><strong>, </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=7850"><strong>7850</strong></a><strong>, and </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=7900"><strong>7900</strong></a><strong> ICP-MS systems, and Agilent </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=8900"><strong>8900</strong></a><strong> and </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=9500"><strong>9500 ICP-QQQ</strong></a><strong> systems.</strong></p><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/br_openlab_icp_ms_software_5994_9288en_agilent_05f01dcdef.pdf"><strong>Full PDF for download</strong></a><strong>&nbsp;</strong></li></ul><p>The brochure introduces <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=OpenLab+ICP-MS+Software"><strong>Agilent OpenLab ICP-MS Software</strong></a>, designed to simplify routine operation and data handling for <strong>Agilent 7800, 7850, and 7900 ICP-MS systems</strong> and the <strong>8900</strong> and <strong>9500</strong> <strong>ICP-QQQ systems</strong>. The software supports the complete analytical workflow—from checking instrument readiness and creating batches to acquisition, data review, reporting, and compliance. A central dashboard provides an overview of system status, maintenance requirements, instrument health, and utilization, while Smart EMF and post-run performance checks help users identify when maintenance may be required. Guided Diagnostics, Meter Monitor, and time-stamped system records also support troubleshooting by tracking parameters such as vacuum levels, gas flows, and temperatures.</p><p>Method and batch setup are designed to reduce manual configuration. Batches can be created from preset methods, templates, existing batches, Method Wizard, or Method Advisor, and legacy Agilent ICP-MS MassHunter batches can be opened directly in OpenLab ICP-MS. For the <strong>9500 ICP-QQQ</strong>, Method Advisor provides an element-focused approach in which users select target elements and calibration information while the software applies recommended acquisition masses and cell-gas conditions. Preset methods are available for applications including <strong>EPA 200.8/EPA 6020, USP &lt;232&gt;, ICH Q3D, and Chinese Pharmacopoeia requirements</strong>, while an IntelliQuant Screening preset supports semiquantitative screening of unknown samples. Routine instrument tasks can also be automated through autotuning, startup checks, batch queues, end-of-run verification, rinse functions, and automatic shutdown.</p><p>For data evaluation, OpenLab ICP-MS provides a real-time workspace where users can review analyte concentrations, internal-standard recoveries, stability plots, spectra or chromatograms, calibration information, QC charts, and IntelliQuant results in a single view. <strong>IntelliQuant</strong> acquires a complete mass spectrum and displays semiquantitative elemental concentrations using a color-coded periodic table, while <strong>IntelliQuant Star Rating</strong> assigns a zero-to-five-star data-quality score based on factors such as potential interferences, calibration quality, background, detection limits, and precision. Reporting options include whole-batch reports, elemental impurity reports for USP &lt;232&gt;/&lt;233&gt; and ICH Q3D, customizable reports, structured CSV export, and direct data transfer to LIMS.</p><p>The software can be expanded for specialized applications, including <strong>LC-ICP-MS and GC-ICP-MS</strong>, advanced QC workflows, single-particle ICP-MS and FFF-ICP-MS, ADS 2 automation, semiconductor analysis, and peripheral-device control. Supported analytical approaches include external calibration, standard additions, semiquantitative calibration, isotope ratios, and isotope dilution. For regulated laboratories, OpenLab ICP-MS can be combined with scalable OpenLab compliance solutions providing electronic signatures, user access control, configurable roles, system activity logs, and audit trails, supporting workflows subject to <strong>21 CFR Part 11, EU Annex 11, and equivalent regulations</strong>. Overall, the platform is positioned as a unified environment for routine and advanced ICP-MS workflows, combining instrument control, method setup, diagnostics, data-quality assessment, reporting, and compliance support.</p><h3><strong>2. Shimadzu: Identification of Virgin PET and Recycled PET by X-ray Fluorescence Spectrometry</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_01_01204_en_f3f20ff020.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User benefits</strong></h5><ul><li>EDX enables the identification of recycled PET.&nbsp;</li><li>Measurements are quick and simple, require no cumbersome pretreatment, and can be automated using a multi-sample turret.&nbsp;</li><li>The instrument offers excellent cost-performance and supports the detection of a wide range of elements.</li></ul><p>Establishing a sustainable circular economy is a major societal challenge, and recycling plastic materials such as PET (polyethylene terephthalate) plays a particularly important role in reducing environmental impact. Large numbers of PET bottles and molded products are used every day in the food and beverage sectors. To recycle these materials safely and reliably, technologies are required that can accurately identify their origin. In practice, however, appearance and conventional physical properties alone are insufficient to distinguish virgin material from recycled material, creating a need for a more reliable identification method.&nbsp;</p><p>For rapid identification in industrial settings, a method requiring little or no pretreatment is highly desirable. In some cases, nondestructive analysis is also needed to enable subsequent application of other analytical techniques. This article presents a practical approach in which metal catalysts present in PET are detected by EDX (Energy-Dispersive X-ray Spectroscopy) and used to distinguish material-recycled PET from virgin PET.</p><h4><strong>Principle and Overview&nbsp;</strong></h4><p>Metal catalysts such as antimony (Sb) and germanium (Ge) are used in the synthesis of PET resin. These catalyst metals have been reported to be useful indicators of material origin. 1),2) For example, Sb and Ge are frequently detected together in material-recycled PET, whereas only one catalyst metal is detected in chemically recycled PET and virgin PET. This likely reflects the fact that material-recycled PET is derived from a mixture of feedstocks using different catalysts.&nbsp;</p><p>ICP-AES (ICP optical emission spectrometry) and ICP-MS (ICP mass spectrometry), which are commonly applied to catalyst metal analysis, provide high sensitivity and accuracy. However, they require pretreatment to convert the sample into a solution, thereby lengthening the analytical workflow. By contrast, EDX can measure solid samples directly, making it well-suited to applications requiring rapid results, such as incoming material inspection and in-line analysis in molding plants. Because EDX is non-destructive, it is also suitable for multimodal analytical workflows.&nbsp;</p><p>On the other hand, some commercially available handheld EDX instruments do not support elements such as Sb and Ge. At the same time, higher-end systems may not offer the specifications or price range needed for industrial deployment. The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=1&amp;search=EDX-7200"><strong>EDX-7200</strong></a> supports a broad range of elements with excellent cost performance. This article describes the analysis of Sb and Ge in PET using this instrument.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>EDX enables rapid and straightforward elemental analysis without cumbersome sample pretreatment. Previous studies have shown that the presence of Sb and Ge can be used to identify recycled PET. Building on this concept, this article presents a practical analytical approach based on EDX. Using the EDX-7200, which combines broad elemental coverage with excellent cost performance, the proposed method provides a practical tool for rapid on-site identification, quality control, and traceability management. When combined with physical property data and other information, this approach is expected to contribute to the safety assessment and quality assurance of recycled materials, thereby supporting a more advanced circular economy.</p><h3><strong>3. Thermo Fisher Scientific: Optimizing lithium-ion battery recycling operations using handheld XRF analysis</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/lithium_ion_battery_recycling_handheld_xrf_analysis_an1120_en_4c00477b78.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The shift to a low-carbon economy and the adoption of electric vehicles will drive an exponential increase in the demand for lithium-ion batteries. As a corollary to this, the International Energy Agency expects the demand for some key commodities to increase significantly over the next two decades: the demand for Copper (Cu) is anticipated to increase by more than 40%; for nickel (Ni) and cobalt (Co), by 60-70% each; and for lithium (Li), by nearly 90%.¹ This will translate into increased mining activities and potentially generate larger amounts of deleterious waste.&nbsp;</p><p>To reduce the environmental impact and limit reliance on scarce commodities associated with economical and geopolitical implications, several countries have implemented regulations regarding producers’ responsibilities.² These regulations contain both incentives and accountability guidelines for lithium-ion battery and electric vehicles manufacturers. Their goal is to facilitate the emergence of a circular economy in which recycling will increasingly contribute to the supply of the strategic raw materials.&nbsp;</p><p>Lithium-ion batteries are made of multiple components, the most valuable being the cathode that contains between 40 and 70% ³, ⁴ of the total value of the battery, depending on its exact chemistry. As of 2023, lithium nickel cobalt manganese oxides (NCM) account for 66% of lithium-ion battery cathode active materials for electric vehicles, followed by lithium iron phosphates (LFP) which account for 24%, and lithium nickel cobalt aluminum oxide (NCA) accounts for the remaining 10%.³</p><h4><strong>Handheld X-ray Fluorescence Analysis&nbsp;</strong></h4><p>Handheld X-ray fluorescence analysis (HHXRF) is an elemental analysis technique that has proven to be cost-effective in recycling areas such as scrap metal and automotive catalytic converters. HHXRF can measure elements from magnesium (Mg) to uranium (U) in various types of materials such as metals and alloys; non-metallic inorganic materials such as ceramics; or ores or plastics. The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1993"><strong>Thermo Scientific™ Niton™ XL2</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1992"><strong>Thermo Scientific™ Niton™ XL5 Plus Handheld XRF Analyzers </strong></a>deliver accurate elemental analysis in real time, with little or no sample preparation, across multiple steps of the lithium-ion battery recycling workflow. Although handheld XRF does not detect lithium, it can measure most elements from the periodic table including nickel or cobalt which often command much higher value than the lithium in a lithium-ion battery.⁴</p><h4><strong>Conclusion&nbsp;</strong></h4><p>There is no ideal process to recycle lithium-ion batteries that simultaneously incorporates low environmental impact, high metal recovery yield, and economic viability. Because of the variety of technologies and materials used, recycling lithium-ion batteries is a complex journey with multiple possible paths. HHXRF helps recyclers by generating lab-quality data in real time, allowing them to optimize their processes and make fast decisions that generate significant benefits:&nbsp;</p><ul><li>Unwanted materials containing heavy metals such as lead or cadmium can be prevented from entering subsequent steps in the recycling workflow.&nbsp;</li><li>Materials can be accurately sorted and adequate processes for recovery selected depending on the material type (e.g., LFP vs. MCM).&nbsp;</li><li>The economic value of incoming and outgoing material can be more accurately estimated.</li></ul><h3><strong>4. Waters Corporation: Waters Aura Systems</strong></h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/720009268_7b9ad02cb4.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The presentation introduces the <strong>Waters Aura Systems</strong>, a family of high-throughput, fluidics-free instruments for the characterization and identification of visible and subvisible particles. All Aura platforms provide particle counting, identification, morphology assessment, and flexible sample volumes ranging from microliters to milliliters. The portfolio includes configurations tailored to different applications: <strong>AuraBMI</strong> for biologics particle analysis, <strong>Aura</strong> for particle analysis with identification, <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2437"><strong>AuraPTx</strong></a> for protein formulation development, <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2438"><strong>AuraGT</strong></a> for gene therapy, <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2439"><strong>AuraCL</strong></a> for cell therapy, and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2190"><strong>Aura+</strong></a> as the most comprehensive platform. The systems are designed for automation-ready operation, straightforward method transfer, and continuity from research through QC.</p><p>A key feature of the Aura platform is the combination of <strong>Backgrounded Membrane Imaging (BMI), Fluorescence Membrane Microscopy (FMM), and Side Illumination Membrane Imaging (SIMI)</strong>. BMI captures particles on a membrane and subtracts the membrane background to improve particle contrast, while FMM uses fluorescent dyes or conjugated antibodies to distinguish specific particle types. This enables differentiation of protein aggregates, cells, viral capsids, degraded excipients, plastics, fibers, and other contaminants that may look similar based on morphology alone. SIMI adds further information for identifying unlabeled inorganic particles such as glass, fibers, and Dynabeads. Together, these techniques provide more specific particle identification than morphology-based classification alone.</p><p>The systems are particularly suited to <strong>biologics, gene therapy, and cell therapy development</strong>. For gene therapy, Aura can evaluate AAV stability, distinguish capsid-related particles, and monitor DNA leakage using SYBR Gold fluorescence, with measurements possible from as little as <strong>5 µL of sample</strong>. For cell therapy, the system can differentiate single cells, cell aggregates, protein aggregates, and extrinsic particles. The platform also supports flexible sample volumes and 24- or 96-well membrane formats, allowing the same general approach to be used from sample-limited early development through larger-volume and QC workflows. The brochure reports excellent quantitative linearity across serial dilutions and emphasizes the ability to preserve sample for additional orthogonal analyses.</p><p>From a technical perspective, Aura Systems provide <strong>100% sampling efficiency</strong>, a particle detection and quantitation range above <strong>1 µm</strong>, and can handle concentrations above <strong>3,000,000 particles/mL</strong> for 1.6 µm particles. Brightfield membrane imaging takes approximately <strong>one minute per sample</strong>, while fluorescence measurements require about <strong>15–30 seconds per sample</strong>. The instruments are compatible with robotic automation and offer different fluorescence-channel configurations depending on the selected Aura model. Overall, the platform is positioned as a comprehensive solution for obtaining quantitative particle counts together with information on particle identity and composition across the development and quality-control lifecycle.</p>

News from LabRulezICPMS Library - Week 36, 2026

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Waters Xevo CDMS charge detection mass spectrometer

Unlock direct mass measurement of megadalton biomolecules with Waters Xevo CDMS. Analyze viral vectors, RNA, and protein complexes with unprecedented precision and single-ion detection.

<p><strong>Understanding the mass and heterogeneity of large and complex biomolecules has long been a barrier to advancement. Conventional techniques fail to resolve the information needed to reconstruct the detailed nuance of structure, especially for megadalton molecular assemblies. It can take months or even years of tedious, expensive research to understand the basics of biomolecular structures.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_CDMS_charge_detection_mass_spectrometer_2_88ab59406f.jpg" alt="Waters: Xevo CDMS charge detection mass spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_CDMS_charge_detection_mass_spectrometer_2_88ab59406f.jpg 234w," sizes="100vw" width="1024" height="682"></p><p>Not anymore. With the breakthrough Xevo CDMS instrument, you can achieve precise measurement of challenging large and highly heterogeneous molecules—including viral vectors, virus-like particles (VLPs), RNA, and protein complexes—that were previously out of reach for mass characterization.</p><p>With this incredible innovation in charge detection mass spectrometry (CDMS), your lab can answer questions that were previously unaskable, unlocking the future of biological science, drug development, cell and gene therapy, and precision medicine.</p><h4><strong>Specifications</strong></h4><ul><li><strong>Technology:</strong> Charge detection mass spectrometry with single-ion detection</li><li><strong>Detection: </strong>Direct mass measurement powered by ELIT technology</li><li><strong>Mass Range: </strong>100 MDa and beyond with molecular weight characterization and purity determination of the​ largest, most heterogenous biotherapeutics</li><li><strong>Resolution: </strong>High-resolution MS analysis of complex mixtures</li><li><strong>Sample Types:</strong> Ideal for a variety of sample types including viral particles, protein assemblies, and exosomes</li><li><strong>Instrument Footprint: </strong>Modern benchtop design with revolutionary nanoESI source</li><li><strong>User Interface:</strong> Intuitive software with guided workflows</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_CDMS_The_ELIT_system_enables_ultra_sensitive_detection_by_isolating_and_measuring_individual_ions_a_capability_not_available_in_traditional_MS_systems_da8ddf4d65.jpg" alt="Waters: Xevo CDMS - The ELIT system enables ultra-sensitive detection by isolating and measuring individual ions—a capability not available in traditional MS systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_CDMS_The_ELIT_system_enables_ultra_sensitive_detection_by_isolating_and_measuring_individual_ions_a_capability_not_available_in_traditional_MS_systems_da8ddf4d65.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Overview</strong></h4><ul><li>Uncover hidden dimensions in biomolecular analysis across cell and gene therapy, biotherapeutics, biophysical science, and nanoparticle research</li><li>Investigate protein structure, function, and mechanisms of diseases at scale with measurement of massive, heterogeneous molecules that were previously invisible</li><li>Achieve real mass clarity with direct, unambiguous, single-ion mass measurement of highly complex, high-mass molecules</li><li>Gain powerful therapeutic insights with characterization of viral vectors, mRNA, and protein complexes</li><li>Get intuitive, ready to submit data workflows, and GxP-ready architecture</li></ul><p><strong>Recommended Use:</strong> For direct analysis of biomolecules in the megadalton range and beyond.</p><h4><strong>Expand biomolecular analysis beyond traditional tools with CDMS</strong></h4><p>Traditional characterization methods like SEC-MALS, analytical ultracentrifugation, and mass photometry often fall short for today’s biomolecules. They require large sample volumes, extended run times, or lack specificity. Xevo CDMS overcomes these limitations with direct, single-ion mass measurement across an extraordinary range, from below 1 MDa to beyond 100 MDa, using as little as 10 µL of sample. With streamlined workflows, faster results, and practical precision, Xevo CDMS delivers insights that conventional tools cannot match, making it a powerful complement or alternative in advanced biomolecular research.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_CDMS_charge_detection_mass_spectrometer_4_72564240d2.jpg" alt="Waters: Xevo CDMS charge detection mass spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_CDMS_charge_detection_mass_spectrometer_4_72564240d2.jpg 234w," sizes="100vw" width="1024" height="683"></p>

Waters Aura+ System for particle characterization

Fast, decisive particle characterization for biologics. Aura+ delivers high-throughput, 5 µL analysis with BMI and FMM imaging for proteins, antibodies, and cell/gene therapies.

<h4><strong>Fast, decisive, low-volume particle characterization analysis for biotherapeutic workflows</strong></h4><p><strong>When you need the flexibility to conduct particle characterization analyses on different types of biologics, including protein and antibody therapeutics, cell therapies, and gene therapies, the Aura+ System has you covered.</strong></p><p>Fully configured to support applications across protein, antibody, cell, and gene therapy workflows, Aura+ brings particle characterization to earlier stages of therapeutic development, so you can make better decisions sooner.</p><p>Powered by the backgrounded membrane imaging (BMI) and fluorescence membrane microscopy (FMM) technology shared within the Aura family of instruments, Aura+ System enables applications from late discovery to development and manufacturing, enhancing decision-making and accelerating your success.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Aura_System_18b9a5e9f5.jpg" alt="Waters: Aura+ System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Aura_System_18b9a5e9f5.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Specifications</strong></h4><ul><li><strong>Imaging area: </strong>24.6 mm2</li><li><strong>Optics: </strong>4x and 20x objectives</li><li><strong>Minimum volume:</strong> 5 µL (assay dependent)</li><li><strong>Resolution:</strong> 1.0 pixel/µm</li><li><strong>Detectable size range: </strong>Range from &gt;1 µm (ECD) to &lt;5 mm (ECD)</li><li><strong>BMI read time: </strong>1 minute/sample</li><li><strong>FMM read time:</strong> 3 FL channels, 30 seconds/sample</li><li><strong>Software:</strong> Particle VUE 4.x all-in-one software suite (image capture and analysis)</li></ul><h4><strong>Overview</strong></h4><ul><li>Save precious material with just 5 µL sample volume requirements&nbsp;</li><li>Get actionable results from a full 96 well plate of labeled samples to data in just 90 minutes</li><li>Boost efficiency with 96-well membrane plate high-throughput capability</li><li>Gain deeper particle insights with advanced imaging</li><li>Rely only on one platform for proteins, antibodies, and cell and gene therapies development</li></ul><p><strong>Recommended Use: </strong>For workflows requiring complete flexibility across a full spectrum of analytes, including biologics, viral vectors, cells, and other contaminants.​</p><h4><strong>Take the guesswork out of your aggregate ID</strong></h4><p>Don’t waste time troubleshooting incorrectly identified aggregates in your therapeutic. Aura+ System uses a combination of brightfield and fluorescent imaging to specifically ID and quantitate cell, viral capsid, protein, degraded excipients, and packaging contaminants so you’ll know exactly what’s in your sample.​</p><p>With high-throughput 96-well plate capability, 5 µL sample volumes, and results in as little as 90 minutes, it offers an efficient solution for detailed particle analysis, meeting USP &lt;788&gt; and &lt;1788&gt; requirements.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Aura_Identify_cell_doublets_and_triplets_1_cellular_aggregates_2_protein_aggregates_3_and_plastic_contaminants_4_in_a_cell_therapeutic_sample_5227e05a6d.jpg" alt="Waters: Aura+ System - Identify cell doublets and triplets (1), cellular aggregates (2), protein aggregates (3), and plastic contaminants (4) in a cell therapeutic sample." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Aura_Identify_cell_doublets_and_triplets_1_cellular_aggregates_2_protein_aggregates_3_and_plastic_contaminants_4_in_a_cell_therapeutic_sample_5227e05a6d.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>BMI: The key to sensitive, robust, early-stage particle characterization</strong></h4><p>Backgrounded membrane imaging (BMI) provides a clearer, faster, and more comprehensive view of what’s really in your sample. By capturing and subtracting background images of the membrane, BMI achieves 10x greater contrast than liquid-based measurements such as light obscuration and flow imaging. Aura+ System provides aggregate data without any clogging concerns or the need for cleaning between measurements.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Aura_BMI_achieves_10x_greater_contrast_than_liquid_based_measurements_such_as_light_obscuration_and_flow_imaging_06d3a7349c.jpg" alt="Waters: Aura+ System - BMI achieves 10x greater contrast than liquid-based measurements such as light obscuration and flow imaging." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Aura_BMI_achieves_10x_greater_contrast_than_liquid_based_measurements_such_as_light_obscuration_and_flow_imaging_06d3a7349c.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Get fast, definitive particle identification with three fluorescence channels</strong></h4><p>The Aura+ System comes with three fluorescence channels so you can get the same information from one experiment that would otherwise take three different studies.</p><p>In addition, The Aura+ System definitively identifies different types of particles within the same sample for more reliable decision-making:</p><ul><li>Three fluorescence membrane microscopy (FMM) channels for three different species of organic particles</li><li>Side illumination membrane imaging (SIMI) channel for extrinsic and inorganic particles</li><li>Ideal for applications including polysorbate degradation, particulate contamination, protein &amp; antibody workflows, cell therapy workflows, AAV aggregation, AAV stability, cell therapy QC, and cell viability</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Aura_Cells_protein_aggregate_and_ig_G_via_immunoassay_6c3e43ecc4.jpg" alt="Waters: Aura+ System - Cells, protein aggregate, and igG (via immunoassay)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Aura_Cells_protein_aggregate_and_ig_G_via_immunoassay_6c3e43ecc4.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Obtain clear details with high magnification</strong></h4><p>With the high magnification capabilities of the Aura+ System, you can see more morphological detail of unlabeled particles, enabling decisive discrimination between your lead and undesirable particles.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Aura_Quickly_differentiate_and_enumerate_cells_versus_Dynabeads_quantify_polysorbate_degradation_and_more_b3e24050f2.jpg" alt="Waters: Aura+ System - Quickly differentiate and enumerate cells versus Dynabeads™, quantify polysorbate degradation, and more." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Aura_Quickly_differentiate_and_enumerate_cells_versus_Dynabeads_quantify_polysorbate_degradation_and_more_b3e24050f2.jpg 234w," sizes="100vw" width="1024" height="682"></p>

Waters Charged Aerosol Detector (CAD)

Waters Charged Aerosol Detector (CAD) enables universal quantitation of non-volatile and semi-volatile compounds independent of UV activity, with wide dynamic range and seamless integration with Empower™ Software.

<h3><strong>Expand Your Detection Range with a Detector Purpose-Built for Empower™ Software</strong></h3><p>Empower™ Software–based laboratories require detection solutions that are easy to adopt, robust, and capable of accurately quantifying non-volatile and semi-volatile compounds—regardless of chemical structure or UV activity.<br>The <strong>Waters Charged Aerosol Detector (CAD)</strong> is purposefully engineered to meet these demands, delivering universal, reliable detection fully integrated with Waters chromatography systems and Empower™ or MassLynx™ Software.</p><p>With a wide dynamic range exceeding four orders of magnitude, the Waters CAD enables <strong>simultaneous quantitation of low-level, non-UV-active analytes</strong>, along with related impurities and excipients, in a single run—helping laboratories reduce method development time, increase productivity, and improve process control.</p><h4><strong>Key Benefits</strong></h4><ul><li><strong>Universal detection without UV limitations</strong><br>Detect and quantify non-volatile and semi-volatile compounds independent of chromophore presence.</li><li><strong>Wide dynamic range (&gt;4 orders of magnitude)</strong><br>Confidently quantify trace-level components and major constituents simultaneously.</li><li><strong>Purpose-built for Empower™ Software</strong><br>Seamless integration into regulated workflows with Empower-based qualification and long-term software compatibility.</li><li><strong>Compatible across Waters LC platforms</strong><br>Integrates easily with Alliance™, Arc™, ACQUITY™ Arc, ACQUITY™ H-Class, ACQUITY™ I-Class, and UPLC™ Systems.</li><li><strong>Designed for robustness and ease of use</strong><br>Optimized hardware, simplified maintenance, and enhanced system protection features minimize downtime.</li></ul><h4><strong>Technical Specifications</strong></h4><h5><strong>Detector Performance</strong></h5><ul><li><strong>Detector flow rate:</strong><br>0.010–2.000 mL/min</li><li><strong>Dynamic range:</strong><br>Greater than four orders of magnitude (four individual power values)</li><li><strong>Sampling rate:</strong><br>Up to 200 Hz</li><li><strong>Number of channels:</strong><br>Four (4), supported by four (4) independent background current channels</li></ul><h5><strong>Temperature Control</strong></h5><ul><li><strong>Evaporation temperature:</strong><ul><li>Ambient (off)</li><li>Controlled range: 10 °C to 100 °C (0.1 °C increments)</li><li>Minimum of 5 °C above ambient</li></ul></li></ul><h5><strong>Gas Requirements</strong></h5><ul><li><strong>Inert gas supply:</strong><br>Nitrogen (recommended) or compressed air</li><li><strong>Inlet pressure:</strong><br>4.83–5.52 bar<br>(483–552 kPa, 70.0–80.0 psi)</li><li><strong>Gas consumption:</strong><br>Typically ≤ 5 L/min</li></ul><h5><strong>Diagnostics and Monitoring</strong></h5><ul><li><strong>Diagnostic channels include:</strong><ul><li>Nebulizer gas flow and pressure (psi)</li><li>Evaporator temperature (°C)</li><li>Ion trap voltage (V)</li><li>Charger current (µA)</li><li>Mixing chamber temperature (°C)</li></ul></li></ul><h5><strong>Electrical and Physical Specifications</strong></h5><ul><li><strong>Power requirements:</strong><br>100–240 VAC</li><li><strong>Dimensions:</strong><ul><li>Width: 34.3 cm (13.5 in)</li><li>Height: 20.8 cm (8.2 in)</li><li>Depth: 61.0 cm (24.0 in)</li></ul></li><li><strong>Biocompatible:</strong><br>No</li></ul><h5><strong>Software and System Compatibility</strong></h5><ul><li>Optimized for <strong>Empower™ Software</strong> and <strong>MassLynx™ Software</strong> control</li><li>Robust chromatography data system (CDS) communications to minimize downtime</li><li>Backward compatibility to <strong>Empower™ 3 Feature Release 4 Service Release 3 (SR3)</strong></li><li>Fully compatible with systems qualification and validation requirements in regulated environments</li></ul><h5><strong>Seamless Method Transfer Across Laboratories</strong></h5><p>The Waters CAD is designed to simplify method transfer within organizations and across external laboratories. It maintains method simplicity while adding enhanced tools for equivalency and reproducibility, reducing the need for revalidation when transitioning from legacy or third-party CAD solutions.</p><p>The intuitive <strong>ACQUITY™ console control panel</strong> enables straightforward operation and simplifies replacement of outdated technology across laboratory networks.</p><h5><strong>Designed for Ease of Use and Reliability</strong></h5><ul><li>Single filter manifold with <strong>push/pull filter replacement</strong></li><li>Easy-to-replace nebulizer for improved serviceability</li><li>Intelligent divert valve automatically sends flow to waste if gas pressure is lost or system errors occur</li><li>Enhanced <strong>leak detection and flood protection</strong>, safeguarding instruments in the event of CDS communication loss</li></ul><h5><strong>Recommended Use</strong></h5><p><strong>Accurate quantitation in:</strong></p><ul><li>HPLC, UHPLC, and UPLC separations</li><li>Preparative and purification workflows</li><li>Pharmaceutical QC and R&amp;D</li><li>Analysis of excipients, lipids, sugars, surfactants, and non-UV-active impurities</li></ul>

Waters Xevo MRT P10 QTof Mass Spectrometer

Ultra-fast HRMS with MRT technology delivering up to 20× higher MS/MS sensitivity, 200 Hz acquisition speed, and exceptional performance for multiomics and imaging applications.

<p><strong>The Waters Xevo MRT P10 Mass Spectrometer is a next-generation high-resolution accurate mass system built on revolutionary Multi-Reflecting Time-of-Flight (MRT) technology. Combining exceptional sensitivity, ultrafast acquisition speed, and outstanding mass accuracy, it establishes a new benchmark for both research and routine analytical laboratories.</strong></p><p>Delivering up to <strong>20-fold higher MS/MS sensitivity</strong> compared with the previous Xevo MRT platform, the system enables confident detection and quantification of low-abundance compounds in highly complex matrices. With acquisition rates of up to <strong>100 Hz in MS mode</strong> and <strong>200 Hz in MS/MS mode</strong>, the Xevo MRT P10 captures comprehensive analytical information without compromising mass accuracy or resolution.</p><p>Advanced acquisition capabilities, including state-of-the-art <strong>DDA</strong>, <strong>DIA</strong>, and <strong>SONAR Pulse Acquisition Mode</strong>, provide deeper analytical insight, improved precursor specificity, and enhanced workflow flexibility for proteomics, lipidomics, metabolomics, spatial biology, and other multiomics applications.</p><p>Combined with the <strong>waters_connect™ Software Platform</strong>, the system supports seamless conversion to mzML format and straightforward integration into existing analytical and bioinformatics workflows.</p><h4><strong>Key Features</strong></h4><ul><li>Revolutionary Multi-Reflecting Time-of-Flight (<strong>MRT) technology</strong></li><li>Up to <strong>20× higher MS/MS sensitivity</strong> than Xevo MRT</li><li>Up to <strong>100,000 FWHM mass resolution</strong></li><li><strong>MS acquisition rates up to 100 Hz</strong></li><li><strong>MS/MS a</strong>cquisition rates up to <strong>200 Hz</strong></li><li>Outstanding mass accuracy and isotopic fidelity</li><li>Advanced <strong>DDA</strong> and <strong>DIA </strong>acquisition modes</li><li><strong>SONAR Pulse Acquisition Mode</strong></li><li>Hybrid targeted and untargeted acquisition workflows</li><li>Deep proteome, lipidome, and metabolome coverage</li><li>Suitable for single-cell analysis</li><li>Direct mzML data export</li><li><strong>waters_connect™ software</strong> integration</li><li>Compact benchtop design</li><li>Compatible with <strong>DESI XS</strong> imaging workflows</li></ul><h3><strong>Technical Specifications</strong></h3><h4><strong>Mass Analyzer</strong></h4><ul><li><strong>Technology: </strong>Multi-Reflecting Time-of-Flight (MRT)</li><li><strong>System type:</strong> High-Resolution Accurate Mass (HRAM)</li></ul><h4><strong>Performance</strong></h4><ul><li><strong>Mass resolution:</strong> up to 100,000 FWHM</li><li><strong>Mass accuracy: </strong>high accuracy in both MS and MS/MS</li><li><strong>Isotopic fidelity:</strong> high-quality isotope pattern accuracy</li></ul><h4><strong>Data Acquisition</strong></h4><ul><li><strong>MS acquisition speed:</strong> up to 100 Hz</li><li><strong>MS/MS acquisition speed: </strong>up to 200 Hz</li><li>Data-Dependent Acquisition (DDA)</li><li>Data-Independent Acquisition (DIA)</li><li>SONAR Pulse Acquisition Mode</li><li>Hybrid targeted and untargeted acquisition</li></ul><h4><strong>Software</strong></h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1544"><strong>waters_connect™ Software Platform</strong></a></li><li>mzML export support</li><li>Bioinformatics workflow integration</li><li>Advanced data processing capabilities</li></ul><h4><strong>Applications</strong></h4><ul><li>Proteomics</li><li>Lipidomics</li><li>Metabolomics</li><li>Multiomics research</li><li>Single-cell analysis</li><li>Biomarker discovery</li><li>Pharmaceutical research</li><li>Translational medicine</li><li>Food analysis</li><li>Environmental testing</li><li>Mass spectrometry imaging</li></ul><h4><strong>Imaging Applications</strong></h4><ul><li>Compatible with DESI XS Source</li><li>High-resolution molecular imaging</li><li>Acquisition speeds up to 200 Hz</li><li>Up to 100,000 FWHM resolution</li></ul>

Waters Cyclic IMS P20 Mass Spectrometer

Cyclic IMS P20 combines high-resolution ion mobility, native MS, and imaging capabilities for detailed structural characterization of complex biological samples.

<p><strong>The Waters Cyclic IMS P20 Mass Spectrometer is a next-generation ion mobility-enabled mass spectrometry platform designed to reveal molecular structure with greater confidence by combining high-resolution cyclic ion mobility separation with accurate mass analysis. The system resolves co-eluting, isomeric, and isobaric species, providing deeper structural insight into complex biological samples.</strong></p><p>Built for advanced research applications, the Cyclic IMS P20 supports proteomics, metabolomics, lipidomics, native mass spectrometry, and mass spectrometry imaging workflows. Multi-pass ion mobility separations, Wideband Enhancement (WBE), and advanced fragmentation technologies provide exceptional analytical depth and sensitivity.</p><p>The platform supports <strong>MALDI XS and DESI XS imaging</strong> workflows, enabling high-confidence spatial analysis and molecular visualization. Additional capabilities including CIU, HDX, ECD, and SID make the system ideally suited for investigating biomolecular structure, stability, dynamics, and intermolecular interactions.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Cyclic_IMS_P20_Mass_Spectrometer_with_MALDI_XS_and_DESI_XS_1a6ac479a1.jpg" alt="Waters: Cyclic IMS P20 Mass Spectrometer with MALDI XS and DESI XS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Cyclic_IMS_P20_Mass_Spectrometer_with_MALDI_XS_and_DESI_XS_1a6ac479a1.jpg 234w," sizes="100vw" width="1024" height="682"></p><h3><strong>Key Features</strong></h3><ul><li>High-resolution Cyclic Ion Mobility Spectrometry</li><li>Separation of isomeric, isobaric, and co-eluting species</li><li>Multi-pass ion mobility separation</li><li>Wideband Enhancement (WBE) technology</li><li>Up to 10× improvement in MS/MS sensitivity</li><li>Advanced native MS capabilities</li><li>Dynamic Field Declustering (DFD)</li><li>Quadrupole mass selection up to 32,000 m/z</li><li>Extended mass range beyond 100,000 m/z</li><li>Electron Capture Dissociation (ECD)</li><li>Surface-Induced Dissociation (SID)</li><li>Integrated Collision-Induced Unfolding (CIU)</li><li>Hydrogen-Deuterium Exchange (HDX) workflows</li><li>MALDI XS and DESI XS imaging support</li><li>Automated CCS calibration</li><li>Intuitive software environment</li><li>Modular and future-proof platform</li></ul><h3><strong>Technical Specifications</strong></h3><h4><strong>Technology</strong></h4><ul><li>Cyclic Ion Mobility Spectrometry (Cyclic IMS)</li><li>Orthogonal Acceleration Time-of-Flight (oaTOF)</li><li>Multi-pass ion mobility separation</li><li>IMSⁿ experiments</li></ul><h4><strong>Advanced Capabilities</strong></h4><ul><li>Wideband Enhancement (WBE)</li><li>Dynamic Field Declustering (DFD)</li><li>Collision-Induced Unfolding (CIU)</li><li>Electron Capture Dissociation (ECD)</li><li>Surface-Induced Dissociation (SID)</li><li>Hydrogen-Deuterium Exchange (HDX)</li></ul><h4><strong>Mass Range</strong></h4><ul><li>Quadrupole selection up to 32,000 m/z</li><li>Detection beyond 100,000 m/z</li></ul><h4><strong>Imaging Applications</strong></h4><ul><li>MALDI XS</li><li>DESI XS</li><li>High-resolution molecular imaging</li><li>Isomeric lipid separation</li></ul><h4><strong>Software</strong></h4><ul><li>Automated CCS calibration</li><li>Advanced method development</li><li>IMS data processing and interpretation</li><li>HDX and CIU workflow support</li></ul><h4><strong>Typical Applications</strong></h4><ul><li>Proteomics</li><li>Native mass spectrometry</li><li>Structural biology</li><li>Lipidomics</li><li>Metabolomics</li><li>Biotherapeutic characterization</li><li>GLP-1 research</li><li>Protein complex analysis</li><li>Molecular imaging</li><li>Forensics</li><li>Environmental analysis</li></ul>

Waters/Wyatt omniDAWN™ MALS detector

Waters omniDAWN is an advanced MALS detector for UPLC/UHPLC, delivering absolute molecular weight and particle size measurements from 200 Da to 1 GDa.

<p><strong>The omniDAWN™ MALS Detector is a next-generation multi-angle light scattering system specifically designed for UPLC™ and UHPLC workflows. It delivers absolute molecular weight and particle size measurements without relying on column calibration or molecular standards, allowing researchers to obtain highly accurate characterization data at true high-performance chromatography speeds.</strong></p><p>Equipped with 18 optimally positioned scattering angles and a flow cell engineered to minimize stray light, omniDAWN measures molar masses from 200 Da to 1 GDa and particle radii from 10 nm to 1 µm. The system is ideally suited for characterization of proteins, antibody-drug conjugates (ADCs), lipid nanoparticles (LNPs), viral vectors, polymers, and other complex macromolecular systems.</p><p>Combined with ASTRA™ software, omniDAWN provides comprehensive characterization of molecular size, molar mass, composition, and stoichiometry. Integrated health monitoring and the COMET™ ultrasonic cleaning module ensure reliable operation, minimal maintenance, and consistent analytical performance.</p><h3><strong>Key Features</strong></h3><ul><li>Purpose-built for UPLC™ and UHPLC systems</li><li>Absolute molecular weight determination without calibration standards</li><li>Absolute particle size characterization</li><li>18 optimized light scattering angles</li><li>Molecular weight range from 200 Da to 1 GDa</li><li>Particle radius range from 10 nm to 1 µm</li><li>High sensitivity with minimal stray light interference</li><li>Up to 4× faster LC-MALS analysis using UPLC</li><li>Reduced sample consumption</li><li>Improved chromatographic resolution</li><li>Advanced workflows for ADCs, LNPs, viral vectors, and polymers</li><li>ASTRA™ software for advanced data analysis</li><li>Integrated System Ready Monitor</li><li>COMET™ ultrasonic in situ cleaning</li><li>Real-time health diagnostics</li><li>Automated system performance monitoring</li></ul><h3><strong>Technical Specifications</strong></h3><h4><strong>Technology</strong></h4><ul><li>Multi-Angle Light Scattering (MALS)</li><li>18 light scattering detectors</li><li>Low stray-light flow cell design</li></ul><h4><strong>Measurement Range</strong></h4><ul><li><strong>Molecular weight:</strong> 200 Da to 1 GDa</li><li><strong>Particle radius: </strong>10 nm to 1 µm</li></ul><h4><strong>Performance</strong></h4><ul><li>UPLC™ and UHPLC compatible</li><li>Up to 4× faster than conventional HPLC-MALS</li><li>Improved chromatographic resolution</li><li>Reduced sample requirements</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Wyatt_omni_DAWN_MALS_photometer_2_61d44b5eca.jpg" alt="Waters/Wyatt: A) Achieve up to 4× faster LC-MALS runs with UPLC. B) Achieve superior separation, revealing fragment peaks not discernible by HPLC." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Wyatt_omni_DAWN_MALS_photometer_2_61d44b5eca.jpg 106w," sizes="100vw" width="400" height="588"></p><h4><strong>Software</strong></h4><ul><li>ASTRA™ Software</li><li>Molecular weight analysis</li><li>Particle size determination</li><li>Conjugate stoichiometry analysis</li><li>ADC characterization</li><li>LNP characterization</li><li>Viral vector characterization</li><li>Polymer branching analysis</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Wyatt_omni_DAWN_MALS_photometer_3_635f3c2555.jpg" alt="Waters/Wyatt: ASTRA software goes beyond measuring overall molecular weight by: A) uniquely resolving individual components to quantify protein and conjugated species and determine stoichiometry, and B) reporting the total protein fraction." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Wyatt_omni_DAWN_MALS_photometer_3_635f3c2555.jpg 244w," sizes="100vw" width="511" height="327"></p><h4><strong>Monitoring and Maintenance</strong></h4><ul><li>System Ready Monitor</li><li>Real-Time Health Monitoring</li><li>COMET™ ultrasonic cleaning</li><li>Automated diagnostics</li><li>Continuous system performance verification</li></ul><h4><strong>Typical Applications</strong></h4><ul><li>Monoclonal antibodies</li><li>Antibody-drug conjugates (ADCs)</li><li>Lipid nanoparticles (LNPs)</li><li>Viral vectors</li><li>Proteins and peptides</li><li>Polymer materials</li><li>Conjugated polymers</li><li>Biotherapeutics</li><li>Nanotechnology research</li></ul>

Waters Alliance iS Bio HPLC System

Alliance iS Bio HPLC combines MaxPeak HPS Technology, bio-inert separations, reduced errors, and enhanced reproducibility for biopharma QC workflows.

<p><strong>The Waters Alliance iS Bio HPLC System is an advanced liquid chromatography platform specifically designed for biopharmaceutical quality control laboratories. Combining exceptional bio-inertness, intuitive operation, and intelligent automation tools, the system helps reduce human error, improve productivity, and ensure consistent analytical performance.</strong></p><p>Featuring <strong>MaxPeak™ High Performance Surfaces (HPS) Technology</strong>, the Alliance iS Bio minimizes unwanted interactions between analytes and metallic flow path surfaces. This improves analyte recovery, sensitivity, reproducibility, and retention time consistency while reducing system conditioning requirements. The technology is particularly beneficial for oligonucleotides, phosphopeptides, monoclonal antibodies, and other metal-sensitive biomolecules.</p><p>The system integrates intuitive touchscreen operation, guided workflows, RFID-enabled column tracking, and advanced compliance-support tools. Combined with corrosion-resistant construction materials and robust performance under challenging operating conditions, the Alliance iS Bio HPLC System is an ideal platform for modern biopharma QC laboratories.</p><h3><strong>Key Features</strong></h3><ul><li>MaxPeak™ High Performance Surfaces (<strong>HPS) Technology</strong></li><li>Highly <strong>bio-inert sample flow path</strong></li><li>Reduced analyte-surface interactions</li><li>Improved analyte recovery and sensitivity</li><li>Enhanced reproducibility and retention time consistency</li><li>Up to 40% reduction in human errors</li><li>Intuitive touchscreen operation</li><li>Guided workflows</li><li><strong>RFID-enabled eConnect column</strong> tracking</li><li><strong>Intelligent Method Translator App</strong> (iMTA)</li><li>Automated column history tracking</li><li>Empower Audit Trail functionality</li><li><strong>waters_connect™</strong> System Monitoring</li><li>Integrated maintenance and troubleshooting tools</li><li><strong>Carryover ≤ 0.002%</strong></li><li>Robust operation across extreme temperature conditions</li><li>Tool-free finger-tight fittings</li></ul><h3><strong>Technical Specifications</strong></h3><h4><strong>Chromatography System</strong></h4><ul><li><strong>System type: </strong>HPLC</li><li><strong>Pump configuration: </strong>Quaternary</li><li><strong>Injection type:</strong> Flow-through needle</li><li><strong>Solvent conditioning:</strong> Passive pre-heating</li></ul><h4><strong>Operating Parameters</strong></h4><ul><li><strong>Maximum operating pressure:</strong> 12,000 psi</li><li><strong>Flow rate range:</strong> 0.001–10.000 mL/min</li><li><strong>pH range:</strong> 1–13</li><li><strong>Carryover:</strong> ≤ 0.002% (caffeine, UV conditions)</li></ul><h4><strong>Sample Management</strong></h4><ul><li><strong>Sample compartment temperature:</strong> 4–40 °C</li><li><strong>Maximum sample capacity:</strong><ul><li>48-position 2.0 mL vial holder</li><li>54-position 2.0 mL vial holder</li><li>96-well plate</li><li>384-well plate</li><li>48-position 0.65 mL microcentrifuge tube plate</li><li>24-position 1.5 mL microcentrifuge tube plate</li></ul></li></ul><h4><strong>Column Management</strong></h4><ul><li>RFID column tracking</li><li>eConnect Waters Column support</li><li><strong>Capacity:</strong><ul><li>One column up to 300 mm length</li><li>Up to 8 mm internal diameter</li></ul></li></ul><h4><strong>Detector Options</strong></h4><ul><li>PDA Detector</li><li>TUV Detector</li></ul><h4><strong>Software and Informatics</strong></h4><ul><li>Empower™ Chromatography Data System (CDS)</li><li>Intelligent Method Translator App (iMTA)</li><li>waters_connect™ Monitoring</li><li>Audit Trail functionality</li><li>Automated column history tracking</li></ul><h4><strong>Construction</strong></h4><ul><li>Inert sample flow path with MaxPeak HPS Technology</li><li>Corrosion-resistant bio-compatible materials</li><li>High-salt tolerant design</li></ul><h4><strong>Dimensions and Weight</strong></h4><ul><li><strong>Width: </strong>49.9 cm</li><li><strong>Height: </strong>74.2 cm</li><li><strong>Depth:</strong> 63.5 cm</li><li><strong>Weight:</strong> 72.5 kg</li></ul><h4><strong>Typical Applications</strong></h4><ul><li>Biopharmaceutical QC</li><li>Monoclonal antibodies (mAbs)</li><li>Oligonucleotide analysis</li><li>Phosphopeptide analysis</li><li>Peptide mapping</li><li>Size exclusion chromatography (SEC)</li><li>Bioseparations</li><li>Pharmaceutical QC</li><li>Regulatory testing laboratories</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_SEC_separation_of_a_USP_m_Ab_System_Suitability_Solution_on_a_legacy_HPLC_system_and_the_Alliance_i_S_Bio_HPLC_System_with_a_Bio_Suite_Diol_SEC_Column_851dc3a90f.jpg" alt="Waters: SEC separation of a USP mAb System Suitability Solution on a legacy HPLC system and the Alliance iS Bio HPLC System with a BioSuite Diol SEC Column." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_SEC_separation_of_a_USP_m_Ab_System_Suitability_Solution_on_a_legacy_HPLC_system_and_the_Alliance_i_S_Bio_HPLC_System_with_a_Bio_Suite_Diol_SEC_Column_851dc3a90f.jpg 234w," sizes="100vw" width="1024" height="682"></p>

Waters Aura PTx System for particle characterization

Aura PTx combines BMI and fluorescence microscopy to rapidly detect protein aggregates and polysorbate degradation from just 5 µL of sample.

<p><strong>The Aura PTx System is an innovative analytical platform designed to accelerate protein formulation development and stability screening for therapeutic drug development. Combining Backgrounded Membrane Imaging (BMI) and Fluorescence Membrane Microscopy (FMM) with dual fluorescence channels, the system enables rapid detection, counting, and characterization of protein aggregates and excipient degradation products within a single experiment.</strong></p><p>Unlike traditional imaging methods that rely solely on particle morphology, Aura PTx can distinguish protein and non-protein particles using fluorescence-based identification. The combination of <strong>Thioflavin T (ThT)</strong> and <strong>BODIPY FL C16</strong> staining enables simultaneous assessment of protein aggregation and polysorbate degradation, two critical indicators of biologic formulation stability.</p><p>Requiring only 5 µL of sample and supporting automated 96-well plate workflows, the Aura PTx System is ideally suited for high-throughput formulation screening during early-stage development of therapeutic proteins, monoclonal antibodies, and other biologics.</p><h3><strong>Key Features</strong></h3><ul><li>Combines BMI and FMM technologies in one platform</li><li>Dual fluorescence channels for simultaneous analysis</li><li>Distinguishes protein and non-protein particles</li><li>Detects and quantifies protein aggregates</li><li>Monitors polysorbate degradation</li><li>Simultaneous protein and excipient stability assessment</li><li>Requires only 5 µL sample volume</li><li>Automated 96-well plate workflow</li><li>High-throughput formulation screening</li><li>No cleaning required between measurements</li><li>Fast sample processing and analysis</li><li>Suitable for Design of Experiments (DoE)</li><li>Supports biologics development</li><li>Early detection of formulation stability issues</li></ul><h3><strong>Technical Specifications</strong></h3><h4><strong>Technology</strong></h4><ul><li>Backgrounded Membrane Imaging (BMI)</li><li>Fluorescence Membrane Microscopy (FMM)</li><li>Dual-channel fluorescence detection</li></ul><h4><strong>Optics</strong></h4><ul><li>Objective: 4×</li><li>Resolution: 1.0 pixel/µm</li><li>Imaging area: 24.6 mm²</li></ul><h4><strong>Particle Detection</strong></h4><ul><li>Detectable size range:<ul><li>1 µm (ECD)</li><li>&lt;5 mm (ECD)</li></ul></li></ul><h4><strong>Sample Handling</strong></h4><ul><li>Minimum sample volume: 5 µL</li><li>Compatible with 96-well plates</li><li>Optimized for high-throughput screening</li></ul><h4><strong>Analysis Speed</strong></h4><ul><li>BMI read time: 1 minute per sample</li><li>FMM read time: 30 seconds per sample</li></ul><h4><strong>Fluorescence Analysis</strong></h4><ul><li>Thioflavin T (ThT) for protein aggregate detection</li><li>BODIPY FL C16 for polysorbate degradation analysis</li><li>Simultaneous protein and excipient characterization</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_Aura_P_Tx_System_tells_you_exactly_what_is_protein_via_Th_T_staining_and_what_is_not_even_in_mixed_particles_9cb34b80b1.jpg" alt="Waters: The Aura PTx System tells you exactly what is protein (via ThT staining) and what is not, even in mixed particles." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_Aura_P_Tx_System_tells_you_exactly_what_is_protein_via_Th_T_staining_and_what_is_not_even_in_mixed_particles_9cb34b80b1.jpg 234w," sizes="100vw" width="1024" height="682"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_Aura_P_Tx_System_is_the_first_to_use_thioflavin_T_Th_T_and_BODIPY_FL_C16_staining_to_detect_and_quantify_protein_aggregates_and_polysorbate_breakdown_fc113affba.jpg" alt="Waters: The Aura PTx System is the first to use thioflavin T (ThT) and BODIPY FL C16 staining to detect and quantify protein aggregates and polysorbate breakdown." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_Aura_P_Tx_System_is_the_first_to_use_thioflavin_T_Th_T_and_BODIPY_FL_C16_staining_to_detect_and_quantify_protein_aggregates_and_polysorbate_breakdown_fc113affba.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Software</strong></h4><ul><li>Particle Vue™ 4.x Software Suite</li><li>Integrated data analysis</li><li>Automated particle identification and characterization</li></ul><h4><strong>Typical Applications</strong></h4><ul><li>Biopharmaceutical development</li><li>Protein formulation screening</li><li>Monoclonal antibodies</li><li>Biosimilars</li><li>Stability studies</li><li>Excipient screening</li><li>Polysorbate degradation monitoring</li><li>Aggregate characterization</li><li>Design of Experiments (DoE)</li><li>Biologics quality control</li></ul>

Waters Aura GT System for particle characterization

Aura GT enables characterization of AAV and viral vectors from just 5 µL of sample, including detection of capsid and DNA aggregates using BMI and FMM technologies.

<p><strong>The Aura GT System is the first dedicated platform designed for the detection, counting, and characterization of viral vectors used in gene therapy, including AAV (Adeno-Associated Virus) and lentiviral vectors. Combining Backgrounded Membrane Imaging (BMI) and Fluorescence Membrane Microscopy (FMM) with dual fluorescence channels, the system enables rapid and reliable assessment of viral particle aggregation and stability during early-stage development.</strong></p><p>Requiring only <strong>5 µL of sample</strong>, Aura GT allows characterization even when only limited material is available. Using fluorescent dyes such as <strong>Thioflavin T (ThT)</strong> and <strong>SYBR™ Gold</strong>, researchers can distinguish capsid aggregates from DNA-containing aggregates, identify root causes of instability, and gain valuable insights into viral vector quality.</p><p>The system supports high-throughput 96-well plate screening and enables direct comparison of formulations, AAV serotypes, production lots, storage conditions, and stability profiles. Results that traditionally required months of work can now be obtained within hours.</p><h3><strong>Key Features</strong></h3><ul><li>Combines <strong>BMI and FMM technologies</strong> in one platform</li><li>Specifically designed for <strong>AAV, lentivirus, and viral vectors</strong></li><li>Detects, counts, and characterizes viral aggregates</li><li>Differentiates <strong>capsid and DNA aggregates</strong></li><li>Identifies root causes of aggregation and instability</li><li>Requires only <strong>5 µL sample volume</strong></li><li>Dual fluorescence channels for simultaneous characterization</li><li>High-throughput <strong>96-well plate screening</strong></li><li>Direct comparison of formulations, serotypes, and production lots</li><li>Viral vector stability assessment</li><li>Actionable results within hours</li><li>Eliminates labor-intensive traditional assays</li><li>Optimized for gene therapy development</li><li>High sensitivity and throughput</li></ul><h3><strong>Technical Specifications</strong></h3><h4><strong>Technology</strong></h4><ul><li>Backgrounded Membrane Imaging (BMI)</li><li>Fluorescence Membrane Microscopy (FMM)</li><li>Dual-channel fluorescence detection</li></ul><h4><strong>Optics</strong></h4><ul><li><strong>Objective:</strong> 4×</li><li><strong>Resolution: </strong>1.0 pixel/µm</li><li><strong>Imaging area: </strong>24.6 mm²</li></ul><h4><strong>Particle Detection</strong></h4><ul><li>Detectable size range:<ul><li>1 µm (ECD)</li><li>&lt;5 mm (ECD)</li></ul></li></ul><h4><strong>Sample Handling</strong></h4><ul><li><strong>Minimum sample volume: </strong>5 µL</li><li><strong>Compatible with 96-well plates</strong></li><li>Optimized for high-throughput screening</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Get_your_gene_therapy_products_to_market_even_faster_with_Aura_GT_System_195d42d00b.jpg" alt="Waters: Get your gene therapy products to market even faster with Aura GT System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Get_your_gene_therapy_products_to_market_even_faster_with_Aura_GT_System_195d42d00b.jpg 245w," sizes="100vw" width="1024" height="522"></p><h4><strong>Analysis Speed</strong></h4><ul><li><strong>BMI read time:</strong> 1 minute per sample</li><li><strong>FMM read time: </strong>30 seconds per sample</li><li>2 fluorescence channels</li></ul><h4><strong>Fluorescence Analysis</strong></h4><ul><li>Thioflavin T (ThT) for capsid aggregate detection</li><li>SYBR™ Gold for DNA detection</li><li>Simultaneous identification of protein and DNA aggregates</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Identify_root_cause_and_characterize_AAV_particles_at_low_volume_with_Aura_GT_System_c3f1c6a334.jpg" alt="Waters: Identify root cause and characterize AAV particles at low volume with Aura GT System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Identify_root_cause_and_characterize_AAV_particles_at_low_volume_with_Aura_GT_System_c3f1c6a334.jpg 234w," sizes="100vw" width="1024" height="683"></p><h4><strong>Software</strong></h4><ul><li>Particle Vue™ 4.x Software Suite</li><li>Image acquisition and analysis</li><li>Automated particle characterization</li></ul><h4><strong>Typical Applications</strong></h4><ul><li>Gene therapy development</li><li>AAV vector characterization</li><li>Lentiviral vectors</li><li>Stability studies</li><li>Aggregation studies</li><li>AAV serotype comparison</li><li>Formulation screening</li><li>Production lot evaluation</li><li>DNA aggregate analysis</li><li>Viral vector development</li></ul>

Waters Aura CL System for particle characterization

Waters Aura CL rapidly identifies cells, aggregates, and residual Dynabeads™ from just 5 µL of sample while assessing viability and purity in cell therapy workflows.

<p><strong>The Aura CL System is the first dedicated platform designed for rapid identification, counting, and characterization of subvisible particles in cell therapy development and manufacturing. Unlike traditional methods, it can reliably distinguish viable cells, unwanted particles, protein aggregates, and manufacturing-related contaminants such as Dynabeads™, while simultaneously providing cell counts, viability information, and sample purity assessment.</strong></p><p>The system combines <strong>Backgrounded Membrane Imaging (BMI)</strong>, <strong>Fluorescence Membrane Microscopy (FMM)</strong>, and <strong>Side Illumination Membrane Imaging (SIMI)</strong> technologies to deliver fast, automated particle analysis without subjective operator interpretation. Through fluorescence labeling, users can clearly differentiate cellular from non-cellular particles, protein from non-protein aggregates, and various cell populations within complex samples.</p><p>Requiring only <strong>5 µL of sample</strong>, Aura CL supports high-throughput screening and can analyze up to 96 samples in less than one hour, making it an ideal solution for cell therapy development, manufacturing, and quality control workflows.</p><h3><strong>Key Features</strong></h3><ul><li>Combines <strong>BMI, FMM, and SIMI </strong>technologies</li><li>Automated identification of <strong>cells and non-cell particles</strong></li><li>Detection and counting of residual<strong> Dynabeads™</strong></li><li>Cell viability assessment</li><li>Characterization of subvisible particles</li><li>Differentiates <strong>protein and non-protein aggregates</strong></li><li>Distinguishes<strong> cellular and non-cellular particles</strong></li><li>Requires only<strong> 5 µL sample volume</strong></li><li>High-throughput <strong>96-well plate screening</strong></li><li>Fully automated analysis workflow</li><li>Results within minutes</li><li>Supports cell therapy development and manufacturing</li><li>Greater accuracy than manual hemocytometry</li><li>Reduces human interpretation errors</li></ul><h3><strong>Technical Specifications</strong></h3><h4><strong>Technology</strong></h4><ul><li>Backgrounded Membrane Imaging (BMI)</li><li>Fluorescence Membrane Microscopy (FMM)</li><li>Side Illumination Membrane Imaging (SIMI)</li></ul><h4><strong>Optics</strong></h4><ul><li><strong>Objectives:</strong><ul><li>4×</li><li>10×</li></ul></li><li><strong>Resolution: </strong>1.0 pixel/µm</li><li><strong>Imaging area:</strong> 24.6 mm²</li></ul><h4><strong>Particle Detection</strong></h4><ul><li>Detectable size range:<ul><li>1 µm (ECD)</li><li>&lt;5 mm (ECD)</li></ul></li></ul><h4><strong>Sample Handling</strong></h4><ul><li><strong>Minimum sample volume: </strong>5 µL</li><li>Compatible with 96-well plates</li><li>Optimized for high-throughput screening</li></ul><h4><strong>Analysis Speed</strong></h4><ul><li><strong>BMI read time: </strong>1 minute per sample</li><li><strong>FMM read time: </strong>30 seconds per sample</li></ul><h4><strong>Fluorescence Analysis</strong></h4><ul><li>Cell and non-cell particle identification</li><li>Cell viability measurements</li><li>Protein aggregate detection</li><li>Non-protein particle detection</li><li>Fluorescent antibody and cell labeling applications</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_With_Aura_CL_System_you_can_achieve_high_throughput_and_definitive_identification_of_viable_cells_and_take_the_guesswork_out_of_cell_viability_assessments_a46a5ee8b4.jpg" alt="Waters: With Aura CL System, you can achieve high-throughput and definitive identification of viable cells and take the guesswork out of cell viability assessments." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_With_Aura_CL_System_you_can_achieve_high_throughput_and_definitive_identification_of_viable_cells_and_take_the_guesswork_out_of_cell_viability_assessments_a46a5ee8b4.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Software</strong></h4><ul><li>Particle Vue™ 4.x Software Suite</li><li>Image acquisition and analysis</li><li>Automated particle classification</li><li>Viability and purity assessment tools</li></ul><h4><strong>Typical Applications</strong></h4><ul><li>Cell therapy development</li><li>CAR-T manufacturing</li><li>Cell product quality control</li><li>Residual Dynabeads™ detection</li><li>Cell viability testing</li><li>Cell culture purity monitoring</li><li>Subvisible particle characterization</li><li>Biologics development</li><li>Lot release testing</li><li>Manufacturing process control</li></ul>

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