<p><strong>Taťána Gazárková is currently a&nbsp;postdoctoral fellow in the Laboratory of Antibiotic Resistance and Microbial Metabolomics. During her doctoral studies, she focused on chromatography and mass spectrometry. Recently, she was awarded second place in the “Sanofi Prize for Pharmacy 2026” competition.</strong></p><p><strong>Taťána Gazárková </strong>is currently a&nbsp;postdoctoral fellow in the <strong>Laboratory of Antibiotic Resistance and Microbial Metabolomics</strong>. During her doctoral studies, she focused on chromatography and mass spectrometry. Recently, she was awarded second place in the <strong>“Sanofi Prize for Pharmacy 2026” </strong>competition, which is awarded by the<strong> French Embassy in the Czech Republic</strong> for her dissertation – Steroid Analysis Using Modern Chromatographic and Mass Spectrometry Techniques: From Fundamental Studies to Targeted Bioanalytical Applications (supervisor: <strong>Lucie Nováková, Charles University</strong>).&nbsp;</p><h5><strong>What makes this field particularly exciting or unique in your view?</strong></h5><p>What I&nbsp;enjoy about analytical chemistry is that, to a&nbsp;certain extent, it is a&nbsp;kind of detective work. You are often looking for ways to “make the invisible visible”. In other words, extract the information you are interested in from a&nbsp;complex sample and then interpret it correctly. What also appeals to me about bioanalytical chemistry is its interdisciplinary nature. It brings together analytical chemistry, biochemistry, biology and medicine, which means that you need to be able not only to translate a&nbsp;biological or clinical question into a&nbsp;measurable analytical experiment, but also to place the resulting data back into a&nbsp;broader biological context. This combination of different perspectives is probably what I&nbsp;enjoy most about the field. At the same time, there is still plenty of room for fundamental research, ranging from studying analytical techniques themselves and improving them to developing new methodological approaches.</p><h5><strong>How did you end up at the </strong><a target="_blank" rel="noopener noreferrer" href="https://mbu.cas.cz/en/research/laboratory-of-antibiotic-resistance-and-microbial-metabolomics"><strong>Laboratory of Antibiotic Resistance and Microbial Metabolomics</strong></a><strong>, and what project are you currently working on?</strong></h5><p>I came to the Institute of Microbiology through a&nbsp;joint project between<strong> Dr Zdeněk Kameník and Assoc. Prof. Jan Bobek from the First Faculty of Medicine, Charles University</strong>. For me, it was also an opportunity to move from targeted analysis and the study of chromatographic techniques towards untargeted metabolomics and new biological questions.</p><p>In the project, we are trying to identify new biologically active compounds that would be effective, particularly against pathogenic fungi. As a&nbsp;potential source of such compounds, we study streptomycetes, bacteria known for their ability to produce a&nbsp;wide range of biologically active compounds, including many antibiotics that are currently in clinical use. We focus on less-explored host-associated streptomycetes, in which we had already observed antifungal activity in previous experiments. We are especially interested in strains active against Candida albicans whose activity cannot be explained by the presence of a&nbsp;known bioactive compound. These strains may represent an interesting source of novel compounds. We then integrate the results of untargeted metabolomic analyses with genomic analyses, which allows us to obtain a&nbsp;more comprehensive view of the biosynthetic potential of selected strains.</p><h5><strong>You also took part in this year’s Vědafest, a&nbsp;science outreach event for the public. What was it like?</strong></h5><p>I already had some experience with science outreach through events such as Researchers’ Night and the Science Fair at my previous institution, but this year’s Vědafest was still new to me in some ways. This time, I&nbsp;was presenting a&nbsp;field that I&nbsp;myself had entered only relatively recently. It was therefore more challenging to find the right analogies and explain the essence of the topic in a&nbsp;way that was simple, yet precise and scientifically accurate. At the same time, that was exactly what made it inspiring. It forces you to look at your own work from a&nbsp;different perspective. What I&nbsp;enjoyed most was the spontaneity and curiosity of the children, who often came up with questions that would never even occur to an adult.</p><h5><strong>What are the biggest challenges you face on your scientific journey, and what helps you overcome them?</strong></h5><p>One of the greatest, but at the same time most interesting, challenges is, in my view, the uncertainty that is inseparably linked to research. For a&nbsp;long time, you often do not know whether you have taken the right direction in addressing a&nbsp;particular question or whether you will ultimately manage to find that figurative final piece of the puzzle. At the same time, this uncertainty is precisely what makes science exciting for me.</p><p>Another major challenge, particularly in interdisciplinary projects, is communication. It is important from the very formulation of a&nbsp;hypothesis and the planning of experiments through to the interpretation of results, including negative ones, and placing them in a&nbsp;broader context. To some extent, every field has its own language, and finding a&nbsp;common understanding is not always straightforward. Personally, I&nbsp;find it very helpful to be able to discuss problems with colleagues on an ongoing basis, whether individually or during regular laboratory seminars. One of the major strengths of our current group is its interdisciplinary nature, which allows me to look at the same problem from several different perspectives. It is also important for me not to lose my curiosity, because that is ultimately what leads us to ask further questions.</p><h5><strong>What are your plans after completing your PhD?</strong></h5><p>After finishing my PhD, I&nbsp;decided that I&nbsp;do not need to have everything that comes next precisely mapped out straight away. I&nbsp;would like to keep different options open for a&nbsp;while and continue building on my experience in analytical chemistry, while at the same time connecting it with other areas that have a&nbsp;biological or medical relevance. I&nbsp;believe that we can keep learning throughout our lives, so I&nbsp;am quite curious to see where the next stage of my journey will take me.</p><p><i>Thank you for the interview!</i></p>

Interview: What Drew Postdoc Taťána Gazárková to Analytical Chemistry

<p><strong>Per- and polyfluoroalkyl substances (PFAS) have earned the moniker "forever chemicals" due to their extreme persistence in the environment. Their detection is crucial for protecting public health and the environment as these synthetic compounds continue to pose significant challenges worldwide. This comprehensive exploration examines why PFAS detection matters, current detection methods, and future directions in addressing PFAS contamination.</strong></p><h3><strong>Understanding PFAS and Their Health Impacts</strong></h3><p>PFAS are a class of synthetic organic compounds with diverse structures, properties, and uses. Despite their diversity, all PFAS contain perfluoroalkyl moieties that are extremely resistant to environmental and metabolic degradation [1]. This high persistence is a defining characteristic that makes PFAS management particularly challenging.</p><h3><strong>Documented Health Effects</strong></h3><p>Current scientific research has linked PFAS exposure to numerous adverse health outcomes:</p><ul><li>Reproductive effects including decreased fertility and increased high blood pressure in pregnant women [8]</li><li>Developmental effects in children such as low birth weight, accelerated puberty, and behavioral changes [8]</li><li>Reduced immune system function, including decreased vaccine response</li><li>Interference with natural hormones and endocrine disruption</li><li>Increased cholesterol levels and obesity risk</li><li>Increased risk of several cancers, including prostate, kidney, testicular, oral cavity/pharynx, brain, and endocrine cancers [3]</li></ul><p>A 2023 study linked PFAS-contaminated water with up to a <strong>33% increase in cancer incidence</strong> in affected areas [3]. The study compared regions with elevated PFAS levels to cancer data from the National Cancer Institute, finding higher incidences of various cancers after controlling for factors like smoking and obesity.</p><h3><strong>Environmental Persistence and Contamination</strong></h3><p>The extreme persistence of PFAS represents a fundamental concern for environmental management. PFAS are considered the most environmentally persistent substances among organic chemicals [7]. This persistence means that even if all PFAS uses were immediately phased out, existing contamination would continue to affect ecosystems and water supplies for generations.</p><p>A 2023 study at a military fire training site estimated that PFAS contamination will persist for centuries without remediation [7]. The research found that terminal PFAS still exceed regulatory limits by 2000-fold decades after aqueous film-forming foam (AFFF) use ceased, with precursors accounting for around half of the extractable organofluorine across years.</p><h3><strong>Current Detection Methods</strong></h3><h4><strong>EPA Standardized Methods</strong></h4><p>The<strong> Environmental Protection Agency (EPA</strong>) has developed several standardized methods for PFAS detection, each with specific applications and capabilities:</p><h5><strong>EPA Method 533</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/epa-533-drying-down-pfas-samples-after-spe"><strong>EPA Method 533</strong></a> focuses on "short chain" PFAS with carbon chain lengths of<strong> C4 to C12</strong>. Released in December 2019, this method complements Method 537.1 and includes several key features:</p><ul><li>Uses isotope dilution quantification approach with extracted internal standards, which reduces overall analytical uncertainty</li><li>Employs weak anion exchange solid phase extraction cartridges as opposed to polystyrene divinylbenzene used in 537.1</li><li>Can analyze 25 PFAS compounds, including additional short-chain PFAS that were not apart of Method 537.1</li><li>Allows for longer holding times: 28 days to extraction and 28 days to analyze (compared to 14 days to extraction in Method 537.1)</li><li>Uses ammonium acetate as a preservative (versus Trisma in Method 537.1) [1]</li></ul><h5><strong>EPA Method 537/537.1</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/sample-concentration-epa-method-537-pfas-determination"><strong>EPA Method 537 </strong></a>was first published in 2009 for the determination of 14 PFAS in drinking water [6]. It was later updated to Method 537.1 in 2018 (with editorial updates in 2020) to expand its capabilities:</p><ul><li>Uses<a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/what-is-solid-phase-extraction-spe"><strong> solid phase extraction (SPE) </strong></a>and<a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/preparing-samples-for-lc-ms/ms-analysis"><strong> liquid chromatography/tandem mass spectrometry (LC-MS/MS)</strong></a></li><li>Method 537.1 expanded detection to 18 PFAS compounds, including HFPO-DA (one component of GenX technology)</li><li>Utilizes styrene-divinylbenzene (SDVB) media for extraction</li><li>Requires samples to be extracted within 14 days and analyzed within 28 days</li><li>Methanol is used to elute the extracts. This should then be reconstituted with a 96:4 methanol:water mixture [1]</li></ul><p>Together, Methods 533 and 537.1 can detect a total of <strong>29 unique PFAS compounds in drinking water </strong>and are approved for monitoring under the fifth Unregulated Contaminant Monitoring Rule (UCMR 5) and the PFAS National Primary Drinking Water Regulation [1] [3].</p><h5><strong>EPA Method 1633</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/preparing-diverse-sample-matrices-for-epa-method-1633"><strong>EPA Method 1633</strong></a>, released in 2024, represents a significant advancement in PFAS analysis:</p><ul><li>Developed for the analysis of <strong>40 PFAS compounds </strong>in various matrices, including surface water, groundwater, wastewater, soil, biosolids, sediment, landfill leachate, and fish tissue</li><li>Expands beyond the drinking water focus of Methods 533 and 537.1</li><li>Provides a standardized approach that may replace modified drinking water methods (i.e., modified EPA 537) that were previously used for non-drinking water matrices [1]</li></ul><h4><strong>Conventional Analytical Techniques</strong></h4><p>The gold standard for PFAS analysis involves chromatographic techniques coupled with mass spectrometry:</p><ul><li>Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) is the most widely used method for PFAS analysis, offering high sensitivity and specificity [1]</li><li>High-Resolution Mass Spectrometry (HRMS) allows for rapid detection and identification of PFAS species at very low concentrations [5]</li></ul><p>These techniques can detect PFAS at parts per trillion (ppt) levels, which is essential given the low concentrations at which PFAS can cause health effects [1]. However, these methods require sophisticated equipment, specialized training, and significant financial resources, making them inaccessible in many regions, particularly in developing countries.</p><h4><strong>Emerging Detection Technologies</strong></h4><p>Several innovative approaches are being developed to address the limitations of conventional methods:</p><ul><li>Electrochemical biosensors using modified electrodes have shown promise for selective PFAS detection with low detection limits [2]</li><li>Surface-Enhanced Raman Spectroscopy (SERS) uses metallic nanoparticles and can be made into a portable method for on-site testing [1]</li><li>Molecular imprinted polymers (MIPs) offer thermal and physical stability, reusability, and low-cost synthesis for PFAS detection [6]</li></ul><p>These emerging technologies aim to provide more accessible, field-deployable, and cost-effective alternatives to traditional laboratory-based methods.</p><h3><strong>Challenges in PFAS Detection</strong></h3><h4><strong>Analytical Challenges</strong></h4><p>Detecting PFAS presents several technical challenges:</p><ul><li>The ubiquity of PFAS in laboratory equipment and accessories can lead to background contamination when measuring at parts-per-trillion levels [1]</li><li>Many components in liquid chromatographs, mass spectrometers, and solid-phase extraction systems contain materials that can leach PFAS compounds [9]</li><li>The vast number of PFAS (thousands of compounds) makes comprehensive detection difficult, as analytical standards are only available for a small subset [1]</li><li>Complex matrices like food and environmental samples require sophisticated sample preparation techniques</li></ul><h4><strong>Global Disparities in Detection Capabilities</strong></h4><p>Access to PFAS detection technology varies significantly worldwide:</p><ul><li>Many developing regions, particularly in Africa, lack adequately equipped laboratories with the necessary instrumentation to detect and measure PFAS</li><li>There is often a scarcity of qualified professionals with experience in PFAS analysis in these regions</li><li>The high cost of acquiring and maintaining sophisticated analytical instruments presents a substantial obstacle to conducting extensive PFAS investigations in resource-limited settings [1]</li><li>Competing priorities such as infectious diseases, poverty, and food security often divert attention and resources from environmental pollutants like PFAS</li></ul><h4><strong>Regulatory Landscape and Compliance</strong></h4><p>The regulatory framework for PFAS is evolving rapidly worldwide:</p><ul><li>The EPA finalized Section 8(a)(7) of the Toxic Substances Control Act in September 2024, requiring manufacturers and importers to report on their use of PFAS since 2011 [10]</li><li>Electronic reporting for PFAS will open on July 11, 2025, with final reporting deadlines in 2026</li><li>Companies must report detailed information including chemical identity, production volumes, industrial and consumer products, worker exposure, and disposal methods [10]</li></ul><p>These regulations are driving demand for more effective and accessible PFAS detection methods to ensure compliance and protect public health.</p><h3><strong>Future Directions in PFAS Detection</strong></h3><h4><strong>Technological Advancements</strong></h4><p>The future of PFAS detection lies in developing more accessible, sensitive, and comprehensive methods:</p><ul><li>Non-targeted screening methods that can identify unknown PFAS compounds without requiring analytical standards for each specific compound</li><li>Total fluorine analysis techniques like Adsorbable Organic Fluorine and Total Oxidizable Precursor Assay that can quantify the presence of fluorine atoms within a sample [1]</li><li>Portable sensors and field-deployable technologies that enable on-site monitoring and rapid response to contamination events</li><li>AI-driven solutions that can improve data analysis and interpretation for complex PFAS mixtures</li></ul><h4><strong>Collaborative Approaches</strong></h4><p>Addressing the global challenge of PFAS detection requires coordinated efforts:</p><ul><li>International partnerships between researchers in developed and developing regions to enhance expertise and capacity building</li><li>Standardization of analytical methods to ensure consistency and comparability of results across different laboratories and regions</li><li>Open data sharing and collaboration across countries to leverage collective knowledge and resources</li><li>Integration of PFAS monitoring into broader environmental and public health surveillance systems</li></ul><h3><strong>Conclusion</strong></h3><p>The detection of PFAS is not merely a technical challenge but a critical public health and environmental imperative [1]. As these "forever chemicals" continue to persist in our environment, developing effective, accessible, and comprehensive detection methods becomes increasingly important. By advancing detection technologies, strengthening regulatory frameworks, and fostering global collaboration, we can better understand, monitor, and ultimately mitigate the impacts of PFAS contamination.</p><p>The EPA's standardized methods (533, 537.1, and 1633) provide crucial tools for monitoring PFAS in various environmental matrices, but continued innovation is needed to address the full spectrum of PFAS compounds and to make detection more accessible globally [1] [6]. The path forward requires sustained investment in research and development, capacity building in resource-limited settings, and a commitment to environmental justice that ensures all communities have access to the tools and information needed to protect themselves from PFAS exposure. Only through such comprehensive approaches can we hope to address the complex challenges posed by these persistent pollutants.</p><p><span>Be sure to check out our other installments of our&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/introducing-our-environmental-contaminants-series-making-sense-of-the-alphabet-soup"><span>Environmental Contaminant Series</span></a><span>&nbsp;covering&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-persistent-organic-pollutants-pops"><span>Persistent Organic Pollutants (POPs)</span></a><span>,&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-polycyclic-aromatic-hydrocarbons-pahs"><span>Polycyclic Aromatic Hydrocarbons (PAHs)</span></a><span>,&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-semi-volatile-organic-compounds-svocs"><span>Semi-Volatile Organic Compounds (SVOCs)</span></a><span>, and </span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-polychlorinated-biphenyls-pcbs"><span>Polychlorinated Biphenyls (PCBs)</span></a><span>.</span></p>

The Importance of Detecting Per- and Polyfluoroalkyl Substances (PFAS)

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezICPMS Library in the week of 31st August 2026? Check out new documents from the field of spectroscopy/spectrometry and related techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT SPECTROSCOPY/SPECTROMETRY RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><strong>LabRulezLCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> libraries.</p></blockquote><p>This week we bring you brochures by <strong>Agilent Technologies </strong>and<strong> Waters Corporation </strong>and application notes by <strong>Shimadzu </strong>and<strong> Thermo Fisher Scientific!</strong></p><h3><strong>1. Agilent Technologies: Agilent OpenLab ICP-MS Software</strong></h3><p><strong>Simplify every step of ICP-MS analysis</strong></p><p><strong>For Agilent </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=7800"><strong>7800</strong></a><strong>, </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=7850"><strong>7850</strong></a><strong>, and </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=7900"><strong>7900</strong></a><strong> ICP-MS systems, and Agilent </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=8900"><strong>8900</strong></a><strong> and </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=9500"><strong>9500 ICP-QQQ</strong></a><strong> systems.</strong></p><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/br_openlab_icp_ms_software_5994_9288en_agilent_05f01dcdef.pdf"><strong>Full PDF for download</strong></a><strong>&nbsp;</strong></li></ul><p>The brochure introduces <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=10&amp;search=OpenLab+ICP-MS+Software"><strong>Agilent OpenLab ICP-MS Software</strong></a>, designed to simplify routine operation and data handling for <strong>Agilent 7800, 7850, and 7900 ICP-MS systems</strong> and the <strong>8900</strong> and <strong>9500</strong> <strong>ICP-QQQ systems</strong>. The software supports the complete analytical workflow—from checking instrument readiness and creating batches to acquisition, data review, reporting, and compliance. A central dashboard provides an overview of system status, maintenance requirements, instrument health, and utilization, while Smart EMF and post-run performance checks help users identify when maintenance may be required. Guided Diagnostics, Meter Monitor, and time-stamped system records also support troubleshooting by tracking parameters such as vacuum levels, gas flows, and temperatures.</p><p>Method and batch setup are designed to reduce manual configuration. Batches can be created from preset methods, templates, existing batches, Method Wizard, or Method Advisor, and legacy Agilent ICP-MS MassHunter batches can be opened directly in OpenLab ICP-MS. For the <strong>9500 ICP-QQQ</strong>, Method Advisor provides an element-focused approach in which users select target elements and calibration information while the software applies recommended acquisition masses and cell-gas conditions. Preset methods are available for applications including <strong>EPA 200.8/EPA 6020, USP &lt;232&gt;, ICH Q3D, and Chinese Pharmacopoeia requirements</strong>, while an IntelliQuant Screening preset supports semiquantitative screening of unknown samples. Routine instrument tasks can also be automated through autotuning, startup checks, batch queues, end-of-run verification, rinse functions, and automatic shutdown.</p><p>For data evaluation, OpenLab ICP-MS provides a real-time workspace where users can review analyte concentrations, internal-standard recoveries, stability plots, spectra or chromatograms, calibration information, QC charts, and IntelliQuant results in a single view. <strong>IntelliQuant</strong> acquires a complete mass spectrum and displays semiquantitative elemental concentrations using a color-coded periodic table, while <strong>IntelliQuant Star Rating</strong> assigns a zero-to-five-star data-quality score based on factors such as potential interferences, calibration quality, background, detection limits, and precision. Reporting options include whole-batch reports, elemental impurity reports for USP &lt;232&gt;/&lt;233&gt; and ICH Q3D, customizable reports, structured CSV export, and direct data transfer to LIMS.</p><p>The software can be expanded for specialized applications, including <strong>LC-ICP-MS and GC-ICP-MS</strong>, advanced QC workflows, single-particle ICP-MS and FFF-ICP-MS, ADS 2 automation, semiconductor analysis, and peripheral-device control. Supported analytical approaches include external calibration, standard additions, semiquantitative calibration, isotope ratios, and isotope dilution. For regulated laboratories, OpenLab ICP-MS can be combined with scalable OpenLab compliance solutions providing electronic signatures, user access control, configurable roles, system activity logs, and audit trails, supporting workflows subject to <strong>21 CFR Part 11, EU Annex 11, and equivalent regulations</strong>. Overall, the platform is positioned as a unified environment for routine and advanced ICP-MS workflows, combining instrument control, method setup, diagnostics, data-quality assessment, reporting, and compliance support.</p><h3><strong>2. Shimadzu: Identification of Virgin PET and Recycled PET by X-ray Fluorescence Spectrometry</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_01_01204_en_f3f20ff020.pdf"><strong>Full PDF for download</strong></a></li></ul><h5><strong>User benefits</strong></h5><ul><li>EDX enables the identification of recycled PET.&nbsp;</li><li>Measurements are quick and simple, require no cumbersome pretreatment, and can be automated using a multi-sample turret.&nbsp;</li><li>The instrument offers excellent cost-performance and supports the detection of a wide range of elements.</li></ul><p>Establishing a sustainable circular economy is a major societal challenge, and recycling plastic materials such as PET (polyethylene terephthalate) plays a particularly important role in reducing environmental impact. Large numbers of PET bottles and molded products are used every day in the food and beverage sectors. To recycle these materials safely and reliably, technologies are required that can accurately identify their origin. In practice, however, appearance and conventional physical properties alone are insufficient to distinguish virgin material from recycled material, creating a need for a more reliable identification method.&nbsp;</p><p>For rapid identification in industrial settings, a method requiring little or no pretreatment is highly desirable. In some cases, nondestructive analysis is also needed to enable subsequent application of other analytical techniques. This article presents a practical approach in which metal catalysts present in PET are detected by EDX (Energy-Dispersive X-ray Spectroscopy) and used to distinguish material-recycled PET from virgin PET.</p><h4><strong>Principle and Overview&nbsp;</strong></h4><p>Metal catalysts such as antimony (Sb) and germanium (Ge) are used in the synthesis of PET resin. These catalyst metals have been reported to be useful indicators of material origin. 1),2) For example, Sb and Ge are frequently detected together in material-recycled PET, whereas only one catalyst metal is detected in chemically recycled PET and virgin PET. This likely reflects the fact that material-recycled PET is derived from a mixture of feedstocks using different catalysts.&nbsp;</p><p>ICP-AES (ICP optical emission spectrometry) and ICP-MS (ICP mass spectrometry), which are commonly applied to catalyst metal analysis, provide high sensitivity and accuracy. However, they require pretreatment to convert the sample into a solution, thereby lengthening the analytical workflow. By contrast, EDX can measure solid samples directly, making it well-suited to applications requiring rapid results, such as incoming material inspection and in-line analysis in molding plants. Because EDX is non-destructive, it is also suitable for multimodal analytical workflows.&nbsp;</p><p>On the other hand, some commercially available handheld EDX instruments do not support elements such as Sb and Ge. At the same time, higher-end systems may not offer the specifications or price range needed for industrial deployment. The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/icpms/library?mainauthorItems=1&amp;search=EDX-7200"><strong>EDX-7200</strong></a> supports a broad range of elements with excellent cost performance. This article describes the analysis of Sb and Ge in PET using this instrument.</p><h4><strong>Conclusion&nbsp;</strong></h4><p>EDX enables rapid and straightforward elemental analysis without cumbersome sample pretreatment. Previous studies have shown that the presence of Sb and Ge can be used to identify recycled PET. Building on this concept, this article presents a practical analytical approach based on EDX. Using the EDX-7200, which combines broad elemental coverage with excellent cost performance, the proposed method provides a practical tool for rapid on-site identification, quality control, and traceability management. When combined with physical property data and other information, this approach is expected to contribute to the safety assessment and quality assurance of recycled materials, thereby supporting a more advanced circular economy.</p><h3><strong>3. Thermo Fisher Scientific: Optimizing lithium-ion battery recycling operations using handheld XRF analysis</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/lithium_ion_battery_recycling_handheld_xrf_analysis_an1120_en_4c00477b78.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The shift to a low-carbon economy and the adoption of electric vehicles will drive an exponential increase in the demand for lithium-ion batteries. As a corollary to this, the International Energy Agency expects the demand for some key commodities to increase significantly over the next two decades: the demand for Copper (Cu) is anticipated to increase by more than 40%; for nickel (Ni) and cobalt (Co), by 60-70% each; and for lithium (Li), by nearly 90%.¹ This will translate into increased mining activities and potentially generate larger amounts of deleterious waste.&nbsp;</p><p>To reduce the environmental impact and limit reliance on scarce commodities associated with economical and geopolitical implications, several countries have implemented regulations regarding producers’ responsibilities.² These regulations contain both incentives and accountability guidelines for lithium-ion battery and electric vehicles manufacturers. Their goal is to facilitate the emergence of a circular economy in which recycling will increasingly contribute to the supply of the strategic raw materials.&nbsp;</p><p>Lithium-ion batteries are made of multiple components, the most valuable being the cathode that contains between 40 and 70% ³, ⁴ of the total value of the battery, depending on its exact chemistry. As of 2023, lithium nickel cobalt manganese oxides (NCM) account for 66% of lithium-ion battery cathode active materials for electric vehicles, followed by lithium iron phosphates (LFP) which account for 24%, and lithium nickel cobalt aluminum oxide (NCA) accounts for the remaining 10%.³</p><h4><strong>Handheld X-ray Fluorescence Analysis&nbsp;</strong></h4><p>Handheld X-ray fluorescence analysis (HHXRF) is an elemental analysis technique that has proven to be cost-effective in recycling areas such as scrap metal and automotive catalytic converters. HHXRF can measure elements from magnesium (Mg) to uranium (U) in various types of materials such as metals and alloys; non-metallic inorganic materials such as ceramics; or ores or plastics. The <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1993"><strong>Thermo Scientific™ Niton™ XL2</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1992"><strong>Thermo Scientific™ Niton™ XL5 Plus Handheld XRF Analyzers </strong></a>deliver accurate elemental analysis in real time, with little or no sample preparation, across multiple steps of the lithium-ion battery recycling workflow. Although handheld XRF does not detect lithium, it can measure most elements from the periodic table including nickel or cobalt which often command much higher value than the lithium in a lithium-ion battery.⁴</p><h4><strong>Conclusion&nbsp;</strong></h4><p>There is no ideal process to recycle lithium-ion batteries that simultaneously incorporates low environmental impact, high metal recovery yield, and economic viability. Because of the variety of technologies and materials used, recycling lithium-ion batteries is a complex journey with multiple possible paths. HHXRF helps recyclers by generating lab-quality data in real time, allowing them to optimize their processes and make fast decisions that generate significant benefits:&nbsp;</p><ul><li>Unwanted materials containing heavy metals such as lead or cadmium can be prevented from entering subsequent steps in the recycling workflow.&nbsp;</li><li>Materials can be accurately sorted and adequate processes for recovery selected depending on the material type (e.g., LFP vs. MCM).&nbsp;</li><li>The economic value of incoming and outgoing material can be more accurately estimated.</li></ul><h3><strong>4. Waters Corporation: Waters Aura Systems</strong></h3><ul><li>Brochure</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/720009268_7b9ad02cb4.pdf"><strong>Full PDF for download</strong></a></li></ul><p>The presentation introduces the <strong>Waters Aura Systems</strong>, a family of high-throughput, fluidics-free instruments for the characterization and identification of visible and subvisible particles. All Aura platforms provide particle counting, identification, morphology assessment, and flexible sample volumes ranging from microliters to milliliters. The portfolio includes configurations tailored to different applications: <strong>AuraBMI</strong> for biologics particle analysis, <strong>Aura</strong> for particle analysis with identification, <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2437"><strong>AuraPTx</strong></a> for protein formulation development, <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2438"><strong>AuraGT</strong></a> for gene therapy, <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2439"><strong>AuraCL</strong></a> for cell therapy, and <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2190"><strong>Aura+</strong></a> as the most comprehensive platform. The systems are designed for automation-ready operation, straightforward method transfer, and continuity from research through QC.</p><p>A key feature of the Aura platform is the combination of <strong>Backgrounded Membrane Imaging (BMI), Fluorescence Membrane Microscopy (FMM), and Side Illumination Membrane Imaging (SIMI)</strong>. BMI captures particles on a membrane and subtracts the membrane background to improve particle contrast, while FMM uses fluorescent dyes or conjugated antibodies to distinguish specific particle types. This enables differentiation of protein aggregates, cells, viral capsids, degraded excipients, plastics, fibers, and other contaminants that may look similar based on morphology alone. SIMI adds further information for identifying unlabeled inorganic particles such as glass, fibers, and Dynabeads. Together, these techniques provide more specific particle identification than morphology-based classification alone.</p><p>The systems are particularly suited to <strong>biologics, gene therapy, and cell therapy development</strong>. For gene therapy, Aura can evaluate AAV stability, distinguish capsid-related particles, and monitor DNA leakage using SYBR Gold fluorescence, with measurements possible from as little as <strong>5 µL of sample</strong>. For cell therapy, the system can differentiate single cells, cell aggregates, protein aggregates, and extrinsic particles. The platform also supports flexible sample volumes and 24- or 96-well membrane formats, allowing the same general approach to be used from sample-limited early development through larger-volume and QC workflows. The brochure reports excellent quantitative linearity across serial dilutions and emphasizes the ability to preserve sample for additional orthogonal analyses.</p><p>From a technical perspective, Aura Systems provide <strong>100% sampling efficiency</strong>, a particle detection and quantitation range above <strong>1 µm</strong>, and can handle concentrations above <strong>3,000,000 particles/mL</strong> for 1.6 µm particles. Brightfield membrane imaging takes approximately <strong>one minute per sample</strong>, while fluorescence measurements require about <strong>15–30 seconds per sample</strong>. The instruments are compatible with robotic automation and offer different fluorescence-channel configurations depending on the selected Aura model. Overall, the platform is positioned as a comprehensive solution for obtaining quantitative particle counts together with information on particle identity and composition across the development and quality-control lifecycle.</p>

News from LabRulezICPMS Library - Week 36, 2026

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The Czech Academy of Sciences (CAS) was established by Act No. 283/1992 Coll. as the Czech successor of the former Czechoslovak Academy of Sciences. It is set up as a complex of 54 public research institutions.

Czech Academy of Sciences

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Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

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Thermo Scientific™ Exactive™ GC Orbitrap™ GC-MS System

High-resolution Orbitrap GC-MS system for confident quantitation and unknown screening. Delivers sub-ppb sensitivity, <1 ppm accuracy, and routine full-scan workflows.

<h4><strong>Bringing high-resolution Orbitrap technology into routine GC-MS workflows</strong></h4><p><strong>The Exactive GC Orbitrap system offers the unmatched mass accuracy, resolving power, and sensitivity of Orbitrap technology in a platform optimized for routine applications. This high-performance GC-MS system enables both targeted and non-targeted full-scan workflows with confident quantitation and trace-level detection, even in complex matrices. Designed for maximum robustness and usability, it streamlines operations across food safety, environmental, industrial, forensic, and anti-doping laboratories.</strong></p><h3><strong>Key Features and Benefits</strong></h3><h4>💡 <strong>Unmatched HRAM Performance</strong></h4><ul><li>Resolving power up to <strong>60,000 FWHM at m/z 200</strong></li><li>Mass accuracy: <strong>&lt;1 ppm</strong> (internal), <strong>&lt;3 ppm</strong> (external)</li><li>Quantitative dynamic range: <strong>&gt;10⁶</strong>, with excellent linearity and precision</li><li>Routine IDLs in the <strong>sub-ppb to ppt range</strong></li></ul><h4>🧪 <strong>Full-Scan Sensitivity and Selectivity</strong></h4><ul><li>Combines triple-quad-like quantitation with full-scan Orbitrap capability</li><li>Sub-ppb sensitivity for 100+ pesticides in food matrices</li><li>High selectivity and confidence in trace-level compound identification</li><li>Spectral deconvolution with accurate-mass fragment filtering</li></ul><h4>⚙️ <strong>Proven Orbitrap Design</strong></h4><ul><li>Curved linear trap (C-Trap) and bent flatapole ion optics</li><li>ExtractaBrite™ ion source (EI/PCI/NCI) – removable under vacuum</li><li>Vent-free column exchange using patented source plug</li><li>Optional direct sample probes (DIP, DEP) for solid or thermolabile analytes</li></ul><h4>🧠 <strong>Streamlined Software and Data Processing</strong></h4><ul><li>Controlled by <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/products/77"><strong>TraceFinder™</strong></a> and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1758"><strong>Xcalibur™</strong></a> platforms</li><li>Full-scan acquisition with automated data mining</li><li>Integrated spectral libraries (NIST, Thermo Food/Environmental)</li><li>Spectral fidelity and mass accuracy retained across wide concentration range</li></ul><h4>🔁 <strong>Optimized GC Integration</strong></h4><ul><li>Built on the <strong>TRACE™ 1310 GC platform</strong></li><li>Supports all injection/detection configurations (SSL, PTV, backflush, etc.)</li><li>Paired with <strong>TriPlus™ RSH autosampler</strong> for advanced robotic sample handling</li><li>Excellent retention time stability and fast oven cycling</li></ul><h3><strong>Ideal For Applications In:</strong></h3><ul><li><strong>Food safety and authenticity</strong> (pesticide screening, additives)</li><li><strong>Environmental analysis</strong> (contaminants, pollutants, air toxics)</li><li><strong>Forensics and toxicology</strong> (unknowns, drugs, metabolites)</li><li><strong>Industrial QC</strong> (extractables, volatiles, impurity profiling)</li><li><strong>Non-targeted screening</strong> with full-scan HRAM and retrospective analysis</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/application::product.product/exactive-gc-orbitrap-gc-ms-front-2000x2000.jpg-650.jpg" alt="Thermo Scientific™ Exactive™ GC Orbitrap™ GC-MS System" width="null" height="null"></p>

Thermo Scientific Orbitrap Exploris 480 Mass Spectrometer

Empowering life science researchers to translate each experimental step to a new level of insight with built-in workflows and single-cell sensitivity.

<p><strong>Empowering life science researchers to translate each experimental step to a new level of insight with built-in workflows and single-cell sensitivity. Accelerate your path to impactful results with a next-generation ownership experience coupled with an intelligence-driven experimental approach. Achieve a new standard in performance to study trace samples with extraordinary accuracy, certainty, confidence and simplicity. You'll find market leading quantitative performance to solve your most complex challenges with ease, and the proven qualitative performance you expect from Orbitrap- based mass spectrometry.</strong></p><p>From exploratory to targeted quantitation, find the power and reliability to make large scale studies possible, while reducing everyday hassles as you increase productivity. And achieving it all, remarkably, within a compact footprint. An extraordinary instrument, providing extraordinary results; the Thermo Scientific Orbitrap Exploris 480 mass spectrometer.</p><h4><strong>Key benefits of the Orbitrap Exploris 480 mass spectrometer</strong></h4><h5><strong>Next-generation experience</strong></h5><p>Built with next-generation common hardware and software architecture, the guiding principle of ultimate performance and ease of use delivers effortless access to the value contained within your data.</p><h5><strong>High performance, high-throughput insights</strong></h5><p>Adding greater performance and intelligence to market-leading selectivity and spectral quality imparts productivity, depth, and certainty to small and large- scale studies.</p><h5><strong>Robust performance and exceptional serviceability increase uptime</strong></h5><p>By design, exceptional end-to-end robustness minimizes need for performance-related maintenance, increasing uptime and sample throughput.</p><h5><strong>Ease-of-use and intelligence to empower all users</strong></h5><p>Differences in user expertise can be a challenge in many laboratories. Workflows based on intelligent data acquisition methods leverage new levels of instrument performance to deliver high confidence, and high throughput.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Ion_path_and_key_components_of_the_Orbitrap_Exploris_480_mass_spectrometer_3f5791378c.webp" alt="Thermo Fisher Scientific: Ion path and key components of the Orbitrap Exploris 480 mass spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Ion_path_and_key_components_of_the_Orbitrap_Exploris_480_mass_spectrometer_3f5791378c.webp 245w," sizes="100vw" width="950" height="410"></p><div><h4><strong>How does the Orbitrap Exploris 480 MS enable greater data insights faster?</strong></h4></div><div><p>See what makes the Orbitrap Exploris 480 MS stand out, how it can empower all users to obtain the highest quality results and deepest insights with the least amount of effort; see how our breakthrough is now your breakthrough.</p></div><ul><li><strong>Next-Generation Instrument Design</strong></li><li><strong>Targeted Protein Quantitation Workflows with SureQuant IS</strong></li><li><strong>Advancing Accuracy, and Precision in Quantitative Proteomics through Multiplexing</strong></li><li><strong>Sub 1-ppm Mass Accuracy as Standard</strong></li><li><strong>Improved Performance through Instrument Enhancements</strong></li><li><strong>Intelligence-Driven Instrument Set-Up, Control and Data Acquisition</strong></li><li><strong>Visualize the Orbitrap Exploris Data Acquisition Modes</strong></li></ul><h4><strong>Optional features to maximize performance</strong></h4><p>Maximize performance and flexibility to expand experimental capabilities of the Orbitrap Exploris 480 mass spectrometer with multiple hardware and software options, allowing you to see more, quantify more, deliver more confidence and greater insights with even more productivity.</p><ul><li><strong>Enhance your Experimental Performance with the FAIMS Pro Duo interface</strong></li><li><strong>Comprehensive and confident biotherapeutic characterization</strong></li></ul><div data-uw-styling-context="true"><h4><strong>Data analysis made easy</strong></h4></div><div data-uw-styling-context="true"><p data-uw-styling-context="true">From complex proteomic challenges, quantitation with SureQuant and TMT multiplexing, through to complete biotherapeutic characterization, data analysis doesn’t have to be the bottleneck to accessing deeper insights into your high-quality MS data. Despite the numerous workflows involved in the analysis of proteins, there are flexible analysis tools which allow simple, yet confident, interpretation of your data to streamline your research and facilitate decision making to take your research to the next level.</p></div><ul><li><strong>Flexibly Identify and Quantify Proteins Based on your Workflow</strong></li><li><strong>The Right Path Towards Complete Biotherapeutic Characterization</strong></li><li><strong>Compliance and Enterprise Readiness with Chromeleon CDS Software</strong><br>&nbsp;</li></ul>

Thermo Scientific Orbitrap Exploris 240 Mass Spectrometer

Maximize performance and flexibility to expand your experimental capabilities, allowing you to discover more, see more, quantify more, and deliver more confidence and greater insights with even more productivity.

<div container-id="cq-colctrl-lt8" comp-id="B2"><div><p><strong>Maximize performance and flexibility to expand your experimental capabilities, allowing you to discover more, see more, quantify more, and deliver more confidence and greater insights with even more productivity.</strong></p><p>Deliver on your objectives with performance to drive discovery and identification, plus receive the quantitative precision and accuracy you need to confidently scale up and achieve impact. With operational simplicity through intelligent data acquisition and processing, discover your fast track to confident results regardless of sample complexity, the depth of insights required or the presence of unknown compounds.</p><h4><strong>Application capabilities through instrument versatility</strong></h4><p>Maximize performance and flexibility to expand your experimental capabilities, allowing you to discover more, see more, quantify more, and deliver more confidence and greater insights with even more productivity.</p><ul><li><strong>Confident and comprehensive proteomic analyses</strong></li><li><strong>Translational proteomics: Scaling translational discoveries into reliable clinical applications</strong></li><li><strong>Comprehensive biotherapeutic characterization: Maximize biotherapeutic insights&nbsp;</strong></li><li><strong>Intact native mass analysis: Maximize biotherapeutic insights&nbsp;</strong></li><li><strong>Metabolomics workflows: One solution for all metabolics workflows&nbsp;</strong></li><li><strong>Clinical research: Translate qualitative and quantitative assays into future clinical applications</strong></li><li><strong>Food/beverage and environmental analyses: Fast-track to results with confidence&nbsp;</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Thermo_Scientific_Orbitrap_Exploris_240_Mass_Spectrometer_a4d2d7771c.jpg" alt="Thermo Fisher Scientific: a) Quantitative experimental design for the analysis of a control and three knockout (KO) strains. b) The orthogonality of the FAIMS Pro interface shows improved peptide coverage when using a range of different CVs. c) Intensity ranking across five orders of quantitative dynamic range for the peptide spectrum matches provided by Proteome Discoverer software. d) Quantitative ratios for each of the samples, highlighting the relative abundance of the KO proteins." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Thermo_Scientific_Orbitrap_Exploris_240_Mass_Spectrometer_a4d2d7771c.jpg 245w," sizes="100vw" width="1000" height="543"></p><div><h4><strong>Key benefits of the Orbitrap Exploris 240 mass spectrometer</strong></h4></div><div><p>Delivering actionable insights faster than ever before by combining proven benefits of Thermo Scientific Orbitrap technology, with sub 1-ppm mass accuracy and high resolution, with intelligent data acquisition and processing.</p></div><h5><strong>Everyday experimental flexibility</strong></h5><p>Discover workhorse versatility from confident proteomic and small-molecule identification and quantitation to biopharmaceutical characterization and in-depth sample-profiling.</p><h5><strong>Faster path to confident insights</strong></h5><p>Delivering actionable insights faster than ever before by combining proven benefits of Thermo Scientific Orbitrap technology, such as sub 1-ppm mass accuracy and high resolution, with intelligent data acquisition and processing.</p><h5><strong>Reliable, robust, and maintainable</strong></h5><p>Meet an exceptional system every day, one with versatility and operational simplicity, but that doesn’t compromise robustness and reliability so you can be confident in its ability to perform on long-term studies.</p><h5><strong>Focus on driving results with faster setup</strong></h5><p>Fully integrated instrument control, setup, and data processing, helps you focus on delivering actionable results while single-system calibrations and pre-defined method templates drive productivity.</p><blockquote><h5><strong>Top reasons to choose Orbitrap Exploris 240 MS over Q-TOF instrumentation</strong></h5><p>Others claim to set new standards in proteomics. Is Protein ID without quantitation sufficient for shotgun proteomics to provide biological insights? Meet the Orbitrap Exploris 240 mass spectrometer – with leading quantitative performance, sensitivity and versatility, designed to meet your needs.</p><p>Trust us to deliver technology innovations that are foundations of reliable workflows and solutions, along with publishable and actionable results.</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/products-and-services/promotions/industrial/10-reasons-choose-orbitrap-exploris-over-qtof.html"><span><strong>Learn more</strong></span></a></li></ul></blockquote><h4><strong>Data Analysis with connectivity to drive productivity</strong></h4><p>From complex proteomic challenges, complete biotherapeutic characterization, or small-molecule discovery to everyday testing, data analysis is your gateway to accessing deeper insights into your high-quality MS and MS2 data. Despite the numerous workflows involved, there are flexible analysis tools for simple, confident interpretation of your data to streamline research and facilitate rapid decision making.</p><ul><li><strong>Flexibly identify and quantify proteins based on your workflow</strong></li><li><strong>Biopharmaceutical characterization with BioPharma Finder software</strong></li><li><strong>Streamline your small-molecule qualitative and quantitative assays</strong></li><li><strong>Small-molecule characterization with Compound Discoverer software</strong></li><li><strong>Complete screening and quantitation using Thermo Scientific TraceFinder software</strong></li><li><strong>Complete compliant control with Chromeleon CDS for MS</strong></li></ul></div></div>

Thermo Scientific Orbitrap Exploris 120 Mass Spectrometer

With its unique ability to provide consistently accurate data and a design made for operational simplicity, it sets the new standard in instrument productivity and ruggedness.

<p><strong>The proven Thermo Scientific Orbitrap technology in the Thermo Scientific Orbitrap Exploris 120 mass spectrometer accelerates your route to qualitative and quantitative confidence for both method development and everyday testing purposes. With its unique ability to provide consistently accurate data and a design made for operational simplicity, it sets the new standard in instrument productivity and ruggedness.</strong></p><h4><strong>Key benefits of the Orbitrap Exploris 120 mass spectrometer&nbsp;</strong></h4><h5><strong>Confidently perform high-throughput qualitative and quantitative analysis</strong></h5><p>Spend less time questioning your results with the unique ability of Orbitrap high-resolution, accurate-mass spectrometers (HRAM) to provide accurate results and reduce false positives or negatives. Confidently resolve ions of interest from interfering ions with high mass resolution up to 120,000 at m/z 200 for both method development and everyday testing analyses.</p><h5><strong>Keep your laboratory running seamlessly with the new standard in instrument ruggedness</strong></h5><p>Maximize return on your investment with capabilities that minimize downtime. Perform a single, stable calibration for the entire mass range from m/z 40-3000. With an improved scan rate up to 22 Hz, maximize your compound coverage with confidence. The ability to do both positive and negative mode switching ensures you analyze twice as many analytes in the same sample.</p><h5><strong>Focus on driving results with faster method set-up</strong></h5><p>Empower high-resolution MS users by giving them the ability to analyze samples using ready-to-run method templates. Minimize time spent on software training for Thermo Scientific MS users with a common software user interface for data acquisition.</p><h4><strong>How the Orbitrap Exploris 120 MS works</strong></h4><p>Discover how the Orbitrap Exploris 120 MS instrument enables you to prioritize your time on making critical decisions which impact the future of you or your client's organization. The latest instrument capabilities have been designed with the sole purpose of putting you on the fast path to accurate, reportable results. Leave the lab at the end of the day feeling productive and accomplished.</p><ul><li><strong>Uncover and quantify more suspect analytes</strong></li><li><strong>Sub-ppm mass accuracy as standard</strong></li><li><strong>System to system consistency</strong></li><li><strong>Robust performance</strong></li><li><strong>Maximize compound coverage with faster scan rates&nbsp;</strong></li><li><strong>Analyze samples twice as fast with rapid polarity switching&nbsp;</strong></li><li><strong>Intelligence-driven instrument setup, control and data acquisition&nbsp;</strong></li><li><strong>Quantitation: Which scan modes do I use on the instrument?</strong></li><li><strong>Take a video tour&nbsp;</strong></li></ul><div><h4><strong>Data analysis software: Streamline small molecule qualitative and quantitative assays</strong></h4></div><div><p>Connecting small molecule unknown identification and characterization through to screening and quantitation doesn’t just stop at data acquisition across multiple platforms. Now that you have acquired comprehensive, high-quality MS and MS<sup>2</sup> data, you need to identify and characterize unknowns and transfer discovery knowledge through to every day testing.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Which_data_analysis_software_is_right_for_you_30a173dd7f.jpg" alt="Thermo Fisher Scientific: Which data analysis software is right for you?" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Which_data_analysis_software_is_right_for_you_30a173dd7f.jpg 213w," sizes="100vw" width="1385" height="1016"></p><p>Our connected data processing software ecosystem streamlines interpretation of your high-confidence discovery data through powerful Thermo Scientific Compound Discoverer software with direct access to the world’s largest LC-MS<sup data-uw-styling-context="true">n</sup> reference spectral library, Thermo Scientific&nbsp;mzCloud, or through utilization of offline or proprietary libraries. These libraries act as your knowledge repository and allow direct transfer through to everyday screening and quantitation using Thermo Scientific&nbsp;TraceFinder software.</p><ul><li><strong>mzCloud Mass Spectral Library</strong></li><li><strong>Small molecule characterization with Compound Discoverer software</strong></li><li><strong>Complete screening and quantitation using TraceFinder software</strong></li><li><strong>Complete compliant control with Chromeleon CDS for MS</strong></li></ul><h4><strong>Common applications for Orbitrap Exploris 120 Mass Spectrometer</strong></h4><p>To perform method development and everyday testing with confidence, you need a liquid chromatography mass spectrometry (LC-MS) workflow solution that is relevant to your laboratory’s goals. The Orbitrap Exploris 120 MS instrument can be used for a variety of applications, including clinical research, environmental and food safety, forensic toxicology, and pharmaceutical analysis.</p><ul><li><strong>Clinical Research</strong></li><li><strong>Forensic Toxicology</strong></li><li><strong>Drug Screening and Confirmation</strong></li><li><strong>Environmental Emerging Contaminants</strong></li><li><strong>Pesticide Residues Analysis</strong></li><li><strong>Veterinary Drugs Residues Analysis</strong></li><li><strong>Pharmaceutical applications</strong></li></ul></div>

Thermo Scientific Orbitrap™ Exploris™ GC Mass Spectrometer

Transform your data quality to deliver the right answer first time, every time with the Thermo Scientific™ Orbitrap™ Exploris™ GC Mass Spectrometer.

<div><div id="product-description"><strong>Simplify operations and deliver consistently accurate results in analytical testing using the Thermo Scientific™ Orbitrap™ Exploris™ GC Mass Spectrometer. This GC-MS system offers a unique depth of analysis and unparalleled accuracy and precision to improve everyday quantitation, screening and sample profiling. It provides the flexibility to keep pace with ever-changing regulations and explore new analytical opportunities through increased scope and method consolidation. Simple instrument set up and intelligent informatics enable users of all abilities to easily access data-rich information.</strong></div><div><h4><strong>Deliver accurate quantitative results and spend less time reviewing data in high throughput analytical testing</strong></h4><ul><li>Offers the power and flexibility of full-scan high-resolution accurate mass data to quantitative, screening and discovery workflows</li><li>Accelerates data reviewing with multi-point compound identification, including spectral matching, isotope pattern match, retention indices and multiple confirmation ions</li></ul><h4><strong>Be one step ahead of changing demands</strong></h4><ul><li>Provides the flexibility to keep pace with ever-changing regulations and enables you to explore new business opportunities through increased scope and method consolidation</li><li>Offers the option to configure the system with either 30,000 or 60,000 mass resolving power and the ability to add MS/MS capability today or in the future</li></ul><h4><strong>Focus on results, not instrument setup</strong></h4><ul><li>Simple instrument set up and intelligent informatics enable users of all abilities to easily access data-rich information</li><li>Next-generation software, including built-in method templates, provides easy-to-use and flexible options that are fully accessible to all members of the analytical team</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Thermo_Scientific_Orbitrap_Exploris_GC_Mass_Spectrometer_337a570de7.jpg" alt="Thermo Fisher Scientific: Thermo Scientific Orbitrap™ Exploris™ GC Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Thermo_Scientific_Orbitrap_Exploris_GC_Mass_Spectrometer_337a570de7.jpg 245w," sizes="100vw" width="1032" height="617"></p><h4><strong>Benefits that boost productivity</strong></h4><h5><strong>Increase scope</strong></h5><p>Gain the flexibility to quickly add new compounds without compound optimization and decide post acquisition which analytes to measure.</p><h5><strong>Fast system setup</strong></h5><p>Walk up, tune, and calibrate in under five minutes with full confidence that the system is operating at maximum performance for all users.</p><h5><strong>Efficient review and reporting</strong></h5><p>Use multiple points of identification to quickly confirm or reject detections, increasing peace of mind. Spectral matching, isotope patterns, retention indices, and elemental compositions provide high confidence in results.</p><h5><strong>Accurate quantitation</strong></h5><p>Six orders of linear dynamic range covers the concentrations encountered in even the most complex sample matrices.</p><h5><strong>Method consolidation</strong></h5><p>Combine acquisition methods onto a single system, reducing the need for multiple systems and streamlining data processing.</p><h5><strong>Retrospective analysis</strong></h5><p>Interrogate previously acquired high-resolution accurate-mass (HRAM) data in multiple ways to answer additional analytical questions without additional sample injections.</p><h4><strong>Power GC-MS with Thermo Scientific software solutions</strong></h4><ul><li><strong>Chromeleon CDS:</strong> Enterprise-ready, regulatory-compliant quantitation</li><li><strong>TraceFinder software:</strong> High-throughput screening and quantitation</li><li><strong>Compound Discoverer software:</strong> Small-molecule unknown identification</li></ul><h3><strong>Specifications</strong></h3><ul><li><strong>Dynamic Range:</strong> &gt;5000 within a single Orbitrap mass analyzer spectrum</li><li><strong>Mass Range: </strong>30 to 3000 m/z</li><li><strong>Mass Accuracy: </strong>External calibration achieves &lt;3 ppm RMS drift over 24 hours, Internal lock mass calibration achieves &lt;1 ppm RMS drift over 24 hours</li><li><strong>Resolution: </strong>Up to 60,000 at m/z 200</li><li><strong>Scan Rates: </strong>Up to 40 Hz at resolution setting 7,500 at m/z 200</li><li><strong>Description:</strong> Orbitrap Exploris GC Mass Spectrometer, no MS/MS</li></ul></div></div>

Thermo Scientific™ Orbitrap™ Exploris™ GC 240 Mass Spectrometer

Take research capability to a new, unprecedented level of performance with the Thermo Scientific™ Orbitrap Exploris™ GC 240 mass spectrometer and accelerate your scientific discovery. 

<p><strong>Simplify the most complex analytical challenges and achieve excellent data quality with the Thermo Scientific™ Orbitrap™ Exploris™ GC 240 mass spectrometer.&nbsp;</strong></p><p>By delivering <strong>uncompromising qualitative and quantitative information</strong>, this <strong>high-resolution accurate-mass GC-MS system</strong> addresses the evolving requirements of research laboratories for <strong>compound identification and quantitation</strong>. From <strong>discovery profiling</strong>, <strong>metabolomics</strong> and <strong>applied quantification</strong>, scientists gain <strong>unparalleled access to information-rich data and results</strong>.</p><p><strong>Experience breakthrough performance in high resolution GC-MS analysis</strong> to gain the <strong>deepest insights</strong> into your sample.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Orbitrap_Exploris_GC_240_Mass_Spectrometer_1_99d830b929/Thermo-Orbitrap-Exploris-GC-240-Mass-Spectrometer-1.jpg" alt="Thermo Scientific™ Orbitrap™ Exploris™ GC 240 Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Orbitrap_Exploris_GC_240_Mass_Spectrometer_1_99d830b929/thumbnail_Thermo-Orbitrap-Exploris-GC-240-Mass-Spectrometer-1.jpg 156w," sizes="100vw" width="650" height="650"></p><h5><strong>The Orbitrap Exploris GC 240 mass spectrometer:</strong></h5><ul><li><strong>Enables you to get the right answer first time</strong></li><li><strong>Offers the flexibility to adapt to ever-changing needs</strong> with its <strong>superior mass accuracy, dynamic range and robustness</strong></li><li><strong>Includes intelligent instrument setup and an intuitive user experience</strong> to make it fully accessible for users of all skill levels</li><li><strong>Offers unprecedented 240,000 resolution (at m/z 200)</strong> to deliver <strong>sub-1-ppm mass accuracy</strong> and <strong>sensitivity down to part-per-trillion concentrations</strong></li><li><strong>Maintains system sensitivity at all mass resolution levels</strong>, so there is <strong>no need to compromise between resolution and sensitivity</strong></li><li><strong>Features repeatable performance injection after injection</strong> to enable discoveries to be made across <strong>high sample studies</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Orbitrap_Exploris_GC_240_Mass_Spectrometer_2_8a411289bf/Thermo-Orbitrap-Exploris-GC-240-Mass-Spectrometer-2.jpg" alt="Thermo Scientific™ Orbitrap™ Exploris™ GC 240 Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Orbitrap_Exploris_GC_240_Mass_Spectrometer_2_8a411289bf/thumbnail_Thermo-Orbitrap-Exploris-GC-240-Mass-Spectrometer-2.jpg 156w," sizes="100vw" width="650" height="650"></p><h3><strong>Thermo Scientific™ Orbitrap™ Exploris™ GC 240 Mass Spectrometer Specifications</strong></h3><ul><li><strong>Description:</strong> Orbitrap Exploris GC 240 Mass Spectrometer</li><li><strong>Dynamic Range:</strong> &gt;5000 within a single Orbitrap mass analyzer spectrum</li><li><strong>Mass Accuracy:</strong> External calibration achieves &lt;3 ppm RMS drift over 24 hours, Internal lock mass calibration achieves &lt;1 ppm RMS drift over 24 hours.</li><li><strong>Scan Rates:</strong> Up to 40 Hz at resolution setting 7,500 at m/z 200</li><li><strong>Mass Range:</strong> 30 to 3000 m/z</li><li><strong>Resolution:</strong> Up to 240,000 at m/z 200</li><li><strong>Unit Size:</strong> Each</li></ul>

Thermo Scientific Q Exactive Plus Hybrid Quadrupole-Orbitrap Mass Spectrometer

Thermo Scientific Q Exactive Plus Hybrid Quadrupole-Orbitrap Mass Spectrometer confidently and routinely characterize, quantify, and confirm in a single analysis using a single mass spectrometer.

<p><strong>Take Quanfirmation™ to the next level. The Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass Spectrometer introduced the revolutionary concept of Quanfirmation. The Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer takes Quanfirmation to the next level with increased performance and new options that enhance applications from confident DMPK qual/quan screening studies to characterization of intact monoclonal antibodies.</strong></p><h5><strong>Superior Quantitation</strong></h5><ul><li><strong>Advanced quadrupole technology (AQT)</strong> improves precursor selection and transmission for more-accurate quantitation of low-abundance analytes in complex matrices</li><li><strong>Sophisticated data-independent acquisition (DIA)</strong> and parallel reaction monitoring (PRM) deliver reproducible quantitation with complete qualitative confidence</li><li>An <strong>advanced active beam guide (AABG) </strong>reduces noise and extends maintenance intervals</li></ul><h5><strong>Enhanced Analysis of Intact Proteins</strong></h5><ul><li><strong>Optional intact protein mode</strong> provides superior trapping of large molecules for improved analysis of intact proteins and protein complexes</li><li><strong>Optional enhanced resolution </strong>ensures maximum ID confidence in top-down proteomics and lipidomics</li></ul><h5><strong>High-Confidence Results</strong></h5><ul><li><strong>HR/AM and full-scan capabilities </strong>capture all sample data, all of the time, enabling retrospective data analysis without need to re-run samples</li><li><strong>Resolving power up to 140,000 FWHM </strong>eliminates isobaric interferences, increasing confidence in results when analyzing samples in complex matrices</li><li><strong>Better than 1-ppm mass accuracy</strong> in full- and all-ion fragmentation (AIF) scan modes ensures confident compound identification</li><li><strong>Fast scanning at 12 Hz</strong> and spectral multiplexing suited to UHPLC applications</li><li><strong>Rapid polarity switching</strong> maximizes information obtained</li><li><strong>AIF and multiple dissociation techniques</strong> — in-source CID and HCD — aid in compound identification</li><li><strong>Mass range to 6000 m/z </strong>enhances detection of singly charged small molecules and biomolecules</li><li><strong>More than four orders of magnitude</strong> intrascan dynamic range, along with femtogram-level sensitivity, allow detection of trace-level and high-abundance compounds in the same scan</li></ul>

Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole Orbitrap™ Mass Spectrometer

Thermo Scientific Q Exactive UHMR Hybrid Quadrupole-Orbitrap MS offers ultra-high mass range native MS with top-down capabilities, extreme sensitivity, and resolution up to 80,000 m/z.

<h3><strong>Go beyond what you thought possible with native mass spectrometry</strong></h3><p>The Thermo Scientific™ Q Exactive™ UHMR is the first hybrid quadrupole-Orbitrap™ mass spectrometer designed specifically for ultra-high mass range (UHMR) native MS and top-down protein analysis. It combines exceptional sensitivity, ultra-high resolution at high m/z, and unique pseudo-MS³ capabilities, enabling detailed characterization of intact protein assemblies and complex biological systems.</p><h3>🔬 <strong>Breakthrough in Native Mass Spectrometry</strong></h3><p>Native mass spectrometry preserves the non-covalent structure and interactions of proteins and protein complexes, making it an indispensable tool for structural biology and biopharma. The Q Exactive UHMR system enables direct mass analysis of intact macromolecules, including membrane proteins, virus capsids, and ribosomal particles—with unrivaled detail.</p><ul><li><strong>Ultra-high mass range detection</strong> up to <strong>80,000 m/z</strong></li><li><strong>Native top-down analysis</strong> of protein complexes and assemblies</li><li><strong>High sensitivity</strong> for precious or low-abundance samples</li><li><strong>Resolve mass differences</strong> even in heterogeneous megaDalton assemblies</li></ul><h3>⚙️ <strong>Technological Innovations</strong></h3><p>The Q Exactive UHMR system integrates multiple hardware advancements to overcome the historical limitations of native MS:</p><ul><li><strong>In-source trapping</strong> for efficient desolvation and controlled dissociation</li><li><strong>Advanced quadrupole mass filter</strong> with selection up to <strong>25,000 m/z</strong></li><li><strong>Reduced RF frequencies</strong> across the ion path for better high-mass transmission</li><li><strong>Pseudo-MS³ capability</strong>: fragment large complexes into subunits, then sequence them in HCD cell</li></ul><h3>🧬 <strong>Applications and Capabilities</strong></h3><h4><strong>Confident characterization of complex biological systems:</strong></h4><ul><li><strong>Virus capsid analysis:</strong> Differentiation and sequencing of 3–4 MDa hepatitis B virus capsids</li><li><strong>Ribosome studies:</strong> Resolution of substoichiometric proteins in E. coli 70S particles</li><li><strong>Membrane proteins:</strong> Gentle liberation from micelles and native top-down sequencing (e.g., AmtB trimer)</li><li><strong>Chaperonin complexes:</strong> Native top-down analysis of GroEL tetradecamer</li></ul><h4><strong>Detect and resolve small differences in high-mass species:</strong></h4><ul><li>Post-translational modifications</li><li>Ligand binding</li><li>Protein truncations and isoforms</li></ul><h3>💡 <strong>Software for Confident Data Interpretation</strong></h3><p>Maximize the power of native MS with industry-leading software:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1837"><strong>BioPharma Finder™ Software</strong> </a>– For intact mass confirmation, top-down analysis, and PTM localization</li><li><strong>ProSightPC™ Software</strong> – Advanced top-down proteomics with integrated UniProt database search</li></ul><h3>🧪 <strong>Who Is It For?</strong></h3><p>Ideal for research groups and industry labs focused on:</p><ul><li>Structural biology</li><li>Biotherapeutic development</li><li>Native and top-down proteomics</li><li>Protein-ligand interaction studies</li></ul><h3>🧭 <strong>Summary of Key Features</strong></h3><ul><li><strong>Mass range:</strong> Up to 80,000 m/z</li><li><strong>Quadrupole isolation:</strong> Up to 25,000 m/z</li><li><strong>Sensitivity:</strong> Orders of magnitude higher at high m/z</li><li><strong>Fragmentation:</strong> HCD, pseudo-MS<sup>3</sup> for native top-down</li><li><strong>In-source trapping:</strong> Yes, optimized for membrane protein assemblies</li><li><strong>Software:</strong> BioPharma Finder, ProSightPC</li><li><strong>Compatible analyses:</strong> Native MS, top-down, intact mass, charge detection</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Q_Exactive_UHMR_Hybrid_Quadrupole_Orbitrap_hmotnostni_spektrometr_a7f594a56d/Pragolab-Thermo-Q-Exactive-UHMR-Hybrid-Quadrupole-Orbitrap-hmotnostni-spektrometr.webp" alt="Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole Orbitrap™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Q_Exactive_UHMR_Hybrid_Quadrupole_Orbitrap_hmotnostni_spektrometr_a7f594a56d/thumbnail_Pragolab-Thermo-Q-Exactive-UHMR-Hybrid-Quadrupole-Orbitrap-hmotnostni-spektrometr.webp 156w," sizes="100vw" width="650" height="650"></p>

Thermo Scientific™ Orbitrap Fusion™ Tribrid™ Mass Spectrometer

Orbitrap Fusion Tribrid MS combines quadrupole, ion trap, and Orbitrap analyzers for ultra-flexible MSⁿ workflows, enabling deep proteomics, PTM analysis, and confident structural elucidation.

<h4><strong>Revolutionary tribrid architecture for comprehensive structural analysis and deep proteome coverage</strong></h4><p>The Orbitrap Fusion Tribrid mass spectrometer combines a quadrupole, a linear ion trap, and an Orbitrap mass analyzer in a unique architecture that delivers unmatched analytical performance. It provides life scientists with advanced MS<sup>n</sup> capabilities, flexibility in fragmentation techniques, and exceptional resolution and speed — ideal for tackling the most complex analytical challenges in proteomics, PTMs, metabolomics, lipidomics, and small molecule research.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Orbitrap_Fusion_Tribrid_hmotnostni_spektrometr_e93c577ae5/Pragolab-Thermo-Orbitrap-Fusion-Tribrid-hmotnostni-spektrometr.webp" alt="Thermo Scientific™ Orbitrap Fusion™ Tribrid™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Orbitrap_Fusion_Tribrid_hmotnostni_spektrometr_e93c577ae5/thumbnail_Pragolab-Thermo-Orbitrap-Fusion-Tribrid-hmotnostni-spektrometr.webp 245w," sizes="100vw" width="1914" height="1059"></p><h3><strong>Key Features and Benefits</strong></h3><h4>🔬 <strong>Revolutionary Tribrid Design</strong></h4><ul><li>Combines <strong>quadrupole</strong>, <strong>linear ion trap</strong>, and <strong>Orbitrap</strong> analyzers</li><li>Perform <strong>MSⁿ up to n = 10</strong> with detection in either ion trap or Orbitrap</li><li>Fragmentation options: <strong>CID</strong>, <strong>HCD</strong>, <strong>ETD</strong>, and <strong>EThcD</strong> at any MS stage</li><li><strong>Synchronous Precursor Selection (SPS)</strong>: up to <strong>20 precursors per scan</strong> for MS³</li></ul><h4>⚙️ <strong>High Performance &amp; Resolution</strong></h4><ul><li><strong>Resolving power up to 500,000 FWHM</strong> at m/z 200</li><li><strong>&lt;1 ppm</strong> mass accuracy with EASY-IC™ internal calibration</li><li><strong>Polarity switching in 1.1 s full cycle</strong></li><li><strong>Scan speeds up to 20 Hz</strong> for Orbitrap and ion trap MSn</li></ul><h4>🧪 <strong>Versatility in Applications</strong></h4><ul><li>Analyze <strong>low-abundance</strong>, <strong>high-complexity</strong>, or structurally complex samples</li><li>Confidently resolve <strong>isobaric interferences</strong> and detect <strong>PTMs</strong></li><li>Full compatibility with <strong>intact protein analysis</strong>, glycoproteomics, and TMT SPS-MS³ quantitation workflows</li></ul><h4>🔁 <strong>Efficient Ion Handling</strong></h4><ul><li><strong>EASY-Max NG</strong> or <strong>NanoSpray Flex NG</strong> ion sources</li><li><strong>Active Beam Guide</strong> and <strong>S-Lens</strong> for efficient ion transmission</li><li><strong>Dynamic Scan Management</strong> optimizes scan scheduling and parallelization</li></ul><h4>💡 <strong>Ease of Use</strong></h4><ul><li>Intuitive <strong>Tune and Method Editors</strong></li><li>Method templates for routine and advanced workflows</li><li><strong>Quanfirmation</strong>: HRAM SIM for quantitation + ion trap MS/MS for confirmation</li><li>Automated calibration, AGC, and exclusion logic</li></ul><h4>🧬 <strong>Compatible Software</strong></h4><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1758"><strong>Xcalibur™</strong></a><strong>, </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1782"><strong>Proteome Discoverer™</strong></a><strong>, </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1756"><strong>ProSight™</strong></a><strong>, </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1757"><strong>Mass Frontier™</strong></a><strong>, </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1759"><strong>Compound Discoverer™</strong></a>, and others</li><li>Support for data-dependent, targeted, and deconvolution workflows</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Orbitrap_Fusion_Tribrid_hmotnostni_spektrometr_2_3d7accb56e/Pragolab-Thermo-Orbitrap-Fusion-Tribrid-hmotnostni-spektrometr-2.webp" alt="Thermo Scientific™ Orbitrap Fusion™ Tribrid™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Orbitrap_Fusion_Tribrid_hmotnostni_spektrometr_2_3d7accb56e/thumbnail_Pragolab-Thermo-Orbitrap-Fusion-Tribrid-hmotnostni-spektrometr-2.webp 245w," sizes="100vw" width="1038" height="622"></p>

Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer

The Orbitrap Fusion Lumos Tribrid MS combines quadrupole, ion trap, and Orbitrap analyzers for high-resolution, ultra-sensitive MSn workflows in proteomics, metabolomics, and biopharma.

<h4><strong>The most powerful tribrid MS platform for deep, multidimensional analysis in proteomics, metabolomics, and structural biology</strong></h4><p>The <strong>Orbitrap Fusion Lumos Tribrid MS</strong> is a cutting-edge mass spectrometer that combines a quadrupole, a linear ion trap, and an Orbitrap™ high-resolution accurate-mass analyzer in a single platform. With unmatched sensitivity, selectivity, and versatility, it enables scientists to tackle complex biological questions with confidence—whether in discovery proteomics, targeted quantitation, top-down protein analysis, glycoproteomics, lipidomics, or small molecule research.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Orbitrap_Fusion_Lumos_Tribrid_hmotnostni_spektrometr_1_39be5478b4/Pragolab-Thermo-Orbitrap-Fusion-Lumos-Tribrid-hmotnostni-spektrometr-1.webp" alt="Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Orbitrap_Fusion_Lumos_Tribrid_hmotnostni_spektrometr_1_39be5478b4/thumbnail_Pragolab-Thermo-Orbitrap-Fusion-Lumos-Tribrid-hmotnostni-spektrometr-1.webp 245w," sizes="100vw" width="1823" height="1068"></p><h3>🔬 <strong>Unmatched Analytical Performance</strong></h3><ul><li><strong>&gt;500,000 resolution</strong> with Orbitrap Ultra-High Field analyzer</li><li><strong>Sub-ppm mass accuracy</strong> with real-time calibration</li><li><strong>Attomole-level quantification</strong> using PRM and DIA</li><li><strong>High sensitivity MS/MS</strong> with HCD, CID, ETD, EThcD, and new ETD HD fragmentation</li></ul><h3>🔄 <strong>Flexibility Across Workflows</strong></h3><ul><li><strong>Tribrid architecture</strong>: combine quadrupole precursor selection, ion trap MSn, and Orbitrap detection</li><li><strong>DIA, PRM, and SPS-MS3</strong> quantification workflows with isobaric tags (e.g., TMT, TMTpro)</li><li><strong>Top-down intact protein analysis</strong> with high sequence coverage</li><li><strong>Fast polarity switching</strong> and intelligent acquisition for lipidomics</li></ul><h3>🧪 <strong>Ideal for Multi-Omics and PTMs</strong></h3><ul><li>Deep profiling of <strong>glycopeptides</strong>, <strong>phosphoproteins</strong>, and other post-translational modifications</li><li>Resolution of <strong>isobaric isoforms</strong>, methylation patterns, and histone modifications</li><li>Confident structure elucidation of small molecules with fine isotope resolution</li></ul><h3>💡 <strong>Smart Technology for Productivity</strong></h3><ul><li><strong>Advanced Quadrupole Technology</strong> (AQT) for high transmission and selectivity</li><li><strong>Automatic gain control (AGC)</strong> for optimal ion population</li><li><strong>Easy ETD™ source</strong> and <strong>vent-free maintenance</strong> with source plug</li><li><strong>Method templates and visual method editor</strong> for intuitive setup</li></ul><h3>🧬 <strong>Applications</strong></h3><ul><li>Quantitative and discovery proteomics (e.g., large-scale TMT SPS-MS3)</li><li>Structural characterization of antibodies and proteoforms</li><li>Targeted metabolite quantitation and small molecule identification</li><li>Comprehensive glycoproteomics and lipidomics workflows</li></ul><h3>🧷 <strong>Software Compatibility</strong></h3><ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1758"><strong>Xcalibur™</strong></a> and <strong>Tune</strong> for control and calibration</li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1782"><strong>Proteome Discoverer™</strong></a><strong>, </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1756"><strong>ProSight™</strong></a><strong>, </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/77"><strong>TraceFinder™</strong></a><strong>, </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1757"><strong>Mass Frontier™</strong></a><strong>, </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1759"><strong>Compound Discoverer™</strong></a> for data analysis across omics</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Orbitrap_Fusion_Lumos_Tribrid_hmotnostni_spektrometr_3_7458a4eb26/Pragolab-Thermo-Orbitrap-Fusion-Lumos-Tribrid-hmotnostni-spektrometr-3.webp" alt="Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Orbitrap_Fusion_Lumos_Tribrid_hmotnostni_spektrometr_3_7458a4eb26/thumbnail_Pragolab-Thermo-Orbitrap-Fusion-Lumos-Tribrid-hmotnostni-spektrometr-3.webp 245w," sizes="100vw" width="2578" height="1296"></p>

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