Revolutionary tribrid architecture for comprehensive structural analysis and deep proteome coverage
The Orbitrap Fusion Tribrid mass spectrometer combines a quadrupole, a linear ion trap, and an Orbitrap mass analyzer in a unique architecture that delivers unmatched analytical performance. It provides life scientists with advanced MSn capabilities, flexibility in fragmentation techniques, and exceptional resolution and speed — ideal for tackling the most complex analytical challenges in proteomics, PTMs, metabolomics, lipidomics, and small molecule research.
Thermo Scientific™ Orbitrap Fusion™ Tribrid™ Mass Spectrometer
Key Features and Benefits
🔬 Revolutionary Tribrid Design
- Combines quadrupole, linear ion trap, and Orbitrap analyzers
- Perform MSⁿ up to n = 10 with detection in either ion trap or Orbitrap
- Fragmentation options: CID, HCD, ETD, and EThcD at any MS stage
- Synchronous Precursor Selection (SPS): up to 20 precursors per scan for MS³
⚙️ High Performance & Resolution
- Resolving power up to 500,000 FWHM at m/z 200
- <1 ppm mass accuracy with EASY-IC™ internal calibration
- Polarity switching in 1.1 s full cycle
- Scan speeds up to 20 Hz for Orbitrap and ion trap MSn
🧪 Versatility in Applications
- Analyze low-abundance, high-complexity, or structurally complex samples
- Confidently resolve isobaric interferences and detect PTMs
- Full compatibility with intact protein analysis, glycoproteomics, and TMT SPS-MS³ quantitation workflows
🔁 Efficient Ion Handling
- EASY-Max NG or NanoSpray Flex NG ion sources
- Active Beam Guide and S-Lens for efficient ion transmission
- Dynamic Scan Management optimizes scan scheduling and parallelization
💡 Ease of Use
- Intuitive Tune and Method Editors
- Method templates for routine and advanced workflows
- Quanfirmation: HRAM SIM for quantitation + ion trap MS/MS for confirmation
- Automated calibration, AGC, and exclusion logic
🧬 Compatible Software
- Xcalibur™, Proteome Discoverer™, ProSight™, Mass Frontier™, Compound Discoverer™, and others
- Support for data-dependent, targeted, and deconvolution workflows
Thermo Scientific™ Orbitrap Fusion™ Tribrid™ Mass Spectrometer
