The most powerful tribrid MS platform for deep, multidimensional analysis in proteomics, metabolomics, and structural biology
The Orbitrap Fusion Lumos Tribrid MS is a cutting-edge mass spectrometer that combines a quadrupole, a linear ion trap, and an Orbitrap™ high-resolution accurate-mass analyzer in a single platform. With unmatched sensitivity, selectivity, and versatility, it enables scientists to tackle complex biological questions with confidence—whether in discovery proteomics, targeted quantitation, top-down protein analysis, glycoproteomics, lipidomics, or small molecule research.
Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer
🔬 Unmatched Analytical Performance
- >500,000 resolution with Orbitrap Ultra-High Field analyzer
- Sub-ppm mass accuracy with real-time calibration
- Attomole-level quantification using PRM and DIA
- High sensitivity MS/MS with HCD, CID, ETD, EThcD, and new ETD HD fragmentation
🔄 Flexibility Across Workflows
- Tribrid architecture: combine quadrupole precursor selection, ion trap MSn, and Orbitrap detection
- DIA, PRM, and SPS-MS3 quantification workflows with isobaric tags (e.g., TMT, TMTpro)
- Top-down intact protein analysis with high sequence coverage
- Fast polarity switching and intelligent acquisition for lipidomics
🧪 Ideal for Multi-Omics and PTMs
- Deep profiling of glycopeptides, phosphoproteins, and other post-translational modifications
- Resolution of isobaric isoforms, methylation patterns, and histone modifications
- Confident structure elucidation of small molecules with fine isotope resolution
💡 Smart Technology for Productivity
- Advanced Quadrupole Technology (AQT) for high transmission and selectivity
- Automatic gain control (AGC) for optimal ion population
- Easy ETD™ source and vent-free maintenance with source plug
- Method templates and visual method editor for intuitive setup
🧬 Applications
- Quantitative and discovery proteomics (e.g., large-scale TMT SPS-MS3)
- Structural characterization of antibodies and proteoforms
- Targeted metabolite quantitation and small molecule identification
- Comprehensive glycoproteomics and lipidomics workflows
🧷 Software Compatibility
- Xcalibur™ and Tune for control and calibration
- Proteome Discoverer™, ProSight™, TraceFinder™, Mass Frontier™, Compound Discoverer™ for data analysis across omics
Thermo Scientific™ Orbitrap Fusion™ Lumos™ Tribrid™ Mass Spectrometer
