Mixed-Mode Solid Phase Extraction (SPE) Sorbent
Incorporates the hydrophobic selectivity of a C8 phase and strong anion-exchange for the extraction of acidic drugs from biological matrices.
Phenomenex: Strata Screen-A- Surface Area (m²/g): -
- Separation Mode: Multi-Mode
- Particle Size: 55
- Recommended Use: Extracts acidic drugs from biological matrices
Starting Method
Strata Screen-A Strong Anion-Exchange
- Condition: 1 mL Methanol
- Equilibrate: 1 mL Water
- Load: Pretreated sample
- Wash 1: 1 mL 25mM Ammonium Acetate Buffer, pH 6-7
- Wash 2: 1 mL Methanol, dry under vacuum for 2-5 min
- Elute: 1 mL 5% Formic Acid in Methanol
Based on 100 mg/1 mL sorbent mass. The above is a convenient starting point for SPE method development, further optimization may be required to tailor the method for your specific extraction needs.
