Confidence in PFAS Data: Smarter Sample Prep, Contamination Control, Highly Sensitive and Robust MS

The increasing focus on ultrashort PFAS, particularly Trifluoroacetic Acid (TFA) and Difluoroacetic Acid (DFA), is creating new analytical challenges for laboratories worldwide. Reliable quantification at trace levels requires a holistic approach that combines regulatory awareness, robust sample preparation, contamination management, optimized chromatography, and sensitive detection.

In this webinar, Phenomenex experts will discuss key regulatory drivers, SPE sorbent selection, official PFAS methods, contamination control strategies and the role of delay columns in achieving reliable PFAS measurements.

SCIEX experts will present a complete workflow for TFA and DFA analysis demonstrating how advanced LC-MS/MS technology and workflow automation help laboratories achieve ultra-sensitive detection, high throughput, and confidence in TFA and DFA analysis across multiple matrices. 

Key Learning Points

• Understand the regulatory landscape and analytical challenges driving PFAS monitoring, with a focus on food, environmental, and emerging ultrashort-chain PFAS applications.
• Implement robust PFAS workflows through optimized SPE sample preparation, appropriate column selection, and contamination management strategies, including the use of delay columns to improve analytical performance.
• Improve data confidence and laboratory productivity by applying best practices for PFAS identification, quantification, and workflow standardization.
• Address the growing challenge of TFA and DFA analysis using highly sensitive, automated LC-MS/MS workflows that deliver reliable results across multiple matrices with minimal hands-on time.

Who should attend:

• Environmental & Drinking Water Laboratories
• Food Testing & Food Safety Laboratories
• PFAS Analysts & Method Development Scientists
• SPE & Sample Preparation Specialists
• LC-MS/MS Users
• Laboratory Managers & Technical Leaders
• Regulatory & Compliance Professionals

Presenter: Luigi Margarucci, PhD (EMEA Seminar and Application Lead, Phenomenex)

Luigi holds a PhD in Pharmaceutical Sciences and began his career at Phenomenex in 2015 as a Technical Sales Consultant. In 2017, he took on the role of Mass Spectrometry Specialist, followed by Chromatography Training Manager in 2020. Since 2021, he has served as Technical Manager for Italy.

He gained extensive experience in chromatography coupled with mass spectrometry while working as a researcher and research fellow at the University of Salerno, collaborating with leading chromatography and mass spectrometry centers in Italy and across Europe, including Utrecht University (The Netherlands).

To date, Luigi has authored 27 scientific publications and has written and delivered numerous seminars on analytical techniques such as HPLC, GC, and SPE. 

Presenter: Jianru Stahl-Zeng (Senior Market Development Manager Food, Environmental and Forensics, SCIEX)

Jianru has been part of SCIEX since 2001. She initially was part of the application Support team and covered not only proteomics but also small molecules applications. Jianru then moved to technical marketing and focused on Food and Environmental applications.

Since 2018, she is managing the EMEAI technical marketing team and projects. Jianru is also the Global Technical Leader for Food and Environmental applications.