Understanding Oligonucleotides & Nucleic Acid Based Bioanalytical Workflows

This webinar provides a foundational overview of sample enrichment approaches and LC analysis workflows for oligonucleotides, DNA, and RNA-based therapeutic molecules.

We will start by exploring the molecular structure and challenges associated with these molecules and learn about the various chromatographic techniques for their comprehensive characterization.

The session will cover the practical approaches for sample preparation and selectivity optimization for gaining higher sensitivity and efficiency in LC-MS/MS methods. Attendees will gain insight into how the method development and optimization approaches can be applied across a variety of DNA and RNA-based molecules for solving the prevalent bioanalytical challenges.

One webinar, two viewing options

Viewing Options

Session 1

• Tuesday, October 27, 2026
  Los Angeles: 10:00 AM PT | New York: 1:00 PM EST
  Mexico City: 12:00 PM CDT

Session 2

• Wednesday, October 28, 2026
  London: 9:00 AM GMT | Berlin: 10:00 AM CET 
  Mumbai: 2:30 PM IST

Key Learning Points

• Describe Nucleic Acids and Oligonucleotides, including their molecular structure, their production process, and how they are delivered as therapeutic medicines. 
• Define the ubiquitous challenges associated with these molecules and define the Critical Quality Attributes (CQAs) for mRNA and explain how they relate to product quality, safety, and performance. 
• Describe common sample enrichment approaches for these molecules.
• Understand the typical workflow designs and their role in supporting downstream LC and LC-MS/MS analysis.  

Who Should Attend

• Any scientists and professionals working in biopharma, life sciences, CROs, CDMOs or analytical laboratories interested in learning about Oligonucleotides and Nucleic Acid based therapeutic analysis workflows as well as sample enrichment and sample preparation approaches.  

Speaker: Namrata Saxena (Technical Manager, Phenomenex)

 Namrata Saxena is the Technical Manager for the Asia-Pacific region at Phenomenex and is part of the global technical team, she provides expert support for a wide range of chromatographic challenges particularly in the characterization of biotherapeutics and emerging cell and gene therapy modalities. Her role includes delivering technical training, hosting seminars and webinars, and contributing to scientific content development. Prior to joining Phenomenex, Namrata worked as a Product Specialist at Bischoff Chromatography GmbH in Germany where she gained extensive experience in stationary phase chemistry, column manufacturing and method development domains. Namrata is based in Sydney, Australia and can be reached through e-mail or phone.