Enhanced Resolution for Longer Oligonucleotide Analytes With a MaxPeak™ Premier Oligonucleotide BEH C18 300 Å Column

Application Note Reproducible Hydrophilic Interaction Chromatography for Denaturing and NonDenaturing Analyses of Oligonucleotides Using GTxResolve Premier BEH Amide Columns Abraham S. Finny, Tatiana Johnston, Brent Sauner, Balasubrahmanyam Addepalli, Matthew A. Lauber Waters Corporation For research use only. Not for use…

Application Note Platform Ion Pairing RPLC Method for Oligonucleotides Using High Throughput 20 mm Length Columns Szabolcs Fekete, Mateusz Imiolek, Matthew A. Lauber Waters Corporation Abstract A novel generic (platform) method is proposed for the separation of oligonucleotide size variants…

Application Note Studying Mobile Phases for HILIC UV/MS Analysis of Oligonucleotide Therapeutics including an siRNA Duplex, a Lipid Conjugated ASO, and a CRISPR sgRNA Szabolcs Fekete, Makda Araya, Balasubrahmanyam Addepalli, Matthew A. Lauber Waters Corporation Abstract Hydrophilic interaction liquid chromatography…

Application Note CRISPR Single Guide RNA Characterization by IP- RP-LC-MS with a Premier Oligonucleotide BEH 300 Å C18 Column Maissa M. Gaye, Chris Knowles, Balasubrahmanyam Addepalli, Matthew A. Lauber Waters Corporation Abstract The high speed, low cost, and reduced need…