Reproducible Hydrophilic Interaction Chromatography for Denaturing and Non- Denaturing Analyses of Oligonucleotides Using GTxResolve Premier BEH Amide Columns

Application Note Studying Mobile Phases for HILIC UV/MS Analysis of Oligonucleotide Therapeutics including an siRNA Duplex, a Lipid Conjugated ASO, and a CRISPR sgRNA Szabolcs Fekete, Makda Araya, Balasubrahmanyam Addepalli, Matthew A. Lauber Waters Corporation Abstract Hydrophilic interaction liquid chromatography…

Application Note Breaking Down RNA Stability: Accelerated Aging of Reference Standards with ASAP prime® Modeling Kristina Flavier1, Chetan Shende1, Justin McCabe1, Christian Reidy2, Makda Araya2, Balasubrahmanyam Addepalli 2 , Koley Hall 3 1 FreeThink Technologies, Inc, Branford CT, USA 2…

CONSUMABLES GUIDE BOOK Characterizing Oligonucleotides Precise and robust chromatographic methods for the characterization of synthetic oligonucleotides CONSUMABLES GUIDE BOOK A Changing Industry Attribute Testing There has been a resurgence in synthetic burgeoning pipelines across the industry. These A synthetic oligonucleotide…

Application Note Bioanalytical HILIC LC-MS Compatibility Using the GTxResolve™ Premier Amide Column and OligoWorks™ SPE Sample Preparation Solution Makda Araya, Mary Trudeau, Balasubrahmanyam Addepalli, Matthew Lauber Waters Corporation, United States Published on September 15, 2025 Application Brief This is an…