Studying Mobile Phases for HILIC UV/MS Analysis of Oligonucleotide Therapeutics including an siRNA Duplex, a Lipid Conjugated ASO, and a CRISPR sgRNA

Application Note Investigating the Strength of the Sense and Antisense Oligonucleotide Interaction to Form siRNA Duplexes Using the BioAccord™ LC-MS System Catalin Doneanu, Ying Qing Yu Waters Corporation, United States Published on August 03, 2026 Abstract A hydrophilic interaction liquid…

Application Note Breaking Down RNA Stability: Accelerated Aging of Reference Standards with ASAP prime® Modeling Kristina Flavier1, Chetan Shende1, Justin McCabe1, Christian Reidy2, Makda Araya2, Balasubrahmanyam Addepalli 2 , Koley Hall 3 1 FreeThink Technologies, Inc, Branford CT, USA 2…

Application Note Expanding the Antibody-Oligo Conjugate (AOC) Characterization Toolbox: Part 2Denaturing and Non-denaturing Analysis of siRNA Payload Samantha Ippoliti, Ying Qing Yu, Connor Brandenburg, Tara MacCulloch Waters Corporation, United States Note: This is the second application note in a three-part…

Application Note Reproducible Hydrophilic Interaction Chromatography for Denaturing and NonDenaturing Analyses of Oligonucleotides Using GTxResolve Premier BEH Amide Columns Abraham S. Finny, Tatiana Johnston, Brent Sauner, Balasubrahmanyam Addepalli, Matthew A. Lauber Waters Corporation For research use only. Not for use…