Learn how NIST MS Interpreter connects accurate-mass MS/MS fragments with molecular structure, enabling substructure assignment, ppm evaluation, candidate modification, and improved unknown identification.

Learn how extracted ion chromatograms support LC–MS/MS identification, quantitation, isotope validation, and troubleshooting in the NIST XIC Analyzer workflow.

Learn how to recognize and search in-source fragmentation spectra in NIST26 using chromatogram results, Score (Unfiltered), and MS/MS Library Search for compound identification.

A practical guide to processing LC-MS/MS data in the NIST26 Chromatogram Window, from parameter setup and library searching to identification review and result export.

Discover the new NIST26 LC-MS/MS workflow with integrated chromatogram analysis, expanded MS/MS libraries, hybrid searching, and advanced tools for confident unknown compound identification.

Learn how NIST MS Search stores library search history, what HLM files are used for, and how to automatically remove temporary files to keep your workspace clean and organized.

Wiley has released the NIST/EPA/NIH EI Mass Spectral Library 2026 and NIST MS/MS Spectral Library 2026, featuring expanded spectral collections, updated search software, and separate EI and MS/MS products.

Learn how to use MS Interpreter in NIST 26 to interpret accurate-mass EI GC-MS spectra, verify library hits, compare candidate structures, and improve compound identification.

Learn how to create retention index calibrations in NIST 26, calculate RI values automatically, and improve GC-MS compound identification by combining spectral library searching with retention indices.

Learn how NIST 26 Hybrid Search expands EI GC-MS library searching by identifying structurally related compounds using mass-shifted fragment matching, DeltaMass analysis, and MS Interpreter validation.