<p><strong>Whether a drug can effectively bind to its target protein, or how different parts of a virus or a cell interact, depends on processes taking place at the level of individual molecules. Their behaviour is determined not only by their shape, but also by the electrostatic forces acting between them. Understanding how these forces are distributed helps scientists explain why certain molecules attract each other, how they bind and how they interact.</strong></p><p>This is where the <a target="_blank" rel="noopener noreferrer" href="https://acc.biodata.ceitec.cz/"><i><strong>Atomic Charge Calculator (ACC)</strong></i></a> comes in. Researchers at Masaryk University have been developing this computational tool for more than a decade. Its third and most advanced generation to date was developed at <strong>CEITEC Masaryk University</strong> and the<strong> Faculty of Science at Masaryk University</strong>, in collaboration with the <strong>Faculty of Informatics at Masaryk University</strong> and <strong>Palacký University Olomouc</strong>.</p><p><strong>ACC III </strong>calculates the electric charges of individual atoms and visualises their distribution directly within three-dimensional molecular structures. It brings together <strong>twenty different calculation methods</strong> in a single environment and can work with a wide range of molecules – from small organic compounds to proteins and other large biomolecular structures.</p><p>A key advantage of <strong>Atomic Charge Calculator III</strong> is that it combines a broad range of computational methods with ease of access. Basic calculations can be performed directly in a web browser, <strong>with no need to install specialised software or register for an account</strong>. The resulting charges can be displayed directly on a 3D model of the molecule. For advanced users and large-scale analyses, the platform also supports automated data processing and allows its computational core to be run locally.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Co_pritahuje_molekuly_Nova_generace_nastroje_z_CEITEC_zviditelnuje_sily_mezi_atomy_d32d7bd2cd.jpg" alt="CEITEC/Biological Data Management and Analysis Core Facility: What Attracts Molecules? A New Generation of a CEITEC Tool Makes the Forces Between Atoms Visible: Oseltamivir bound to influenza virus neuraminidase (blue: positive partial charges, red: negative charges). A strong electrostatic interaction occurs between a negatively charged region of the drug and positively charged regions of the protein." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Co_pritahuje_molekuly_Nova_generace_nastroje_z_CEITEC_zviditelnuje_sily_mezi_atomy_d32d7bd2cd.jpg 140w," sizes="100vw" width="1600" height="1786"></p><h3><strong>Why are scientists interested in the electric charges of atoms?</strong></h3><p>Electrons are not distributed evenly within molecules. Individual atoms can therefore carry different partial electric charges. These charges play an important role in determining how molecules behave towards their surroundings and towards one another.</p><p>Positively and negatively charged regions of molecules can attract each other, while regions with the same charge repel each other. The distribution of these charges therefore helps determine which molecules approach each other, how they orient themselves and how strongly they may bind. In biology, this is important, for example, in molecular recognition or when a drug binds to its target protein. Understanding partial charges therefore helps scientists gain insight into the interactions underlying the behaviour of many molecular systems.</p><p>There is, however, no single universal way to determine partial charges. Different computational methods can produce different values, and the choice of method also depends on how the results will be used. Accurate quantum-chemical calculations can also become very computationally demanding when large numbers of structures are involved. ACC III therefore brings together<strong> empirical methods </strong>that allow these calculations to be performed more quickly and on a large scale.</p><p><i>“From the outset, we designed ACC III to make calculating partial atomic charges as straightforward as possible. Users do not need to install anything or deal with complicated settings – they simply upload a molecule and start the calculation with a single click. The application then suggests suitable methods from the twenty available and can handle both small molecules and large biomolecular structures,”</i> says <a target="_blank" rel="noopener noreferrer" href="https://www.ceitec.eu/tomas-racek-ph-d/u94476?page=publication"><strong>Tomáš Raček</strong></a>, who has been developing and maintaining ACC since 2018.</p><h3><strong>How an antiviral drug binds to an influenza virus protein</strong></h3><p>The authors demonstrate what charge distribution can reveal using the well-known antiviral drug oseltamivir, marketed as Tamiflu. The drug binds to neuraminidase, a protein of the influenza A virus. ACC III can show directly within the three-dimensional structure where positive and negative partial charges are located and how they contribute to the interaction between the drug and the protein.</p><p><i>“The example of oseltamivir clearly shows why it is useful not only to calculate the charges, but also to visualise them directly within the structure. This allows us to see which parts of the two molecules interact electrostatically. The same approach can be used to study many other molecular systems,”</i> explains Tomáš Raček.</p><p><strong>ACC III is not limited to small molecules</strong>. It can also work with proteins and other large biomolecular structures. The authors demonstrate this using a second example: the <strong>SARS-CoV-2 </strong>pore complex. Coronaviruses form these pores during replication in infected cells and use them to transport viral RNA across membranes. Visualising partial charges helps distinguish the parts of the complex that pass through the non-polar environment of the membrane from its more highly charged regions.</p><h3><strong>From calculation straight to a 3D model</strong></h3><p>The new generation of the Atomic Charge Calculator also offers<strong> more advanced visualisation</strong>. It uses Mol*, which allows calculated charges to be mapped directly onto a three-dimensional structure and explored interactively. A visualisation created using ACC III was also selected for the<strong> cover of the special </strong><i><strong>Nucleic Acids Research</strong></i><strong> Web Server Issue</strong>. Created by Tomáš Raček, the cover image shows the distribution of partial charges in a membrane protein system.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Co_pritahuje_molekuly_Nova_generace_nastroje_z_CEITEC_zviditelnuje_sily_mezi_atomy_3_85cc310925.jpeg" alt="CEITEC/Oxford University Press: What Attracts Molecules? A New Generation of a CEITEC Tool Makes the Forces Between Atoms Visible: Cover page in Nucleic Acids Research journal." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Co_pritahuje_molekuly_Nova_generace_nastroje_z_CEITEC_zviditelnuje_sily_mezi_atomy_3_85cc310925.jpeg 124w," sizes="100vw" width="1600" height="2011"></p><p>Results can be downloaded in several standard formats and, for the first time, stored directly in the mmCIF format commonly used for three-dimensional biomolecular structures. Information about the structure and its calculated charges can therefore remain together in a single file and be used by other tools.</p><p>For researchers who need to process large numbers of structures, ACC III also provides an API and a computational core that can be run locally. The platform can therefore be used both for individual calculations through its web interface and as part of larger automated analyses.</p><h3><strong>More than a decade of development</strong></h3><p>Scientists introduced the first Atomic Charge Calculator in <strong>2015</strong>, followed by its second generation in <strong>2020</strong>. In the meantime, the team also developed specialised tools: PDBCharges for structures from the Protein Data Bank and AlphaCharges for structures from the AlphaFold Database.</p><p><i>“The Atomic Charge Calculator was never a one-off project,”</i> says <a target="_blank" rel="noopener noreferrer" href="https://www.ceitec.eu/prof-radka-svobodova-ph-d/u17518?page=publication"><strong>Radka Svobodová</strong></a>, Head of the Biological Data Management and Analysis Core Facility at CEITEC Masaryk University. <i>“For more than a decade, we have been continuously developing tools that respond both to new possibilities in structural bioinformatics and to the needs of their users. The third generation combines straightforward web-based use with capabilities that are important for the automated processing of large numbers of molecular structures.”</i></p><blockquote><p><strong>Atomic Charge Calculator III is freely available through its web interface and does not require registration for basic use.</strong> Its development was supported by the<strong> ELIXIR CZ </strong>research infrastructure.</p></blockquote><h5><strong>The authors presented the new generation of the tool in </strong><a target="_blank" rel="noopener noreferrer" href="https://academic.oup.com/nar/article/54/W1/W211/8662890"><i><strong>Nucleic Acids Research</strong></i></a><strong>.</strong></h5>

What Attracts Molecules? A New Generation of a CEITEC Tool Makes the Forces Between Atoms Visible 

<p><span><strong>Not every concentration job can tolerate heat — and not every concentrator that handles heat well can handle cold. </strong></span><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2441"><span><strong>Refrigerated centrifugal vacuum concentrators</strong></span></a><span><strong> exist for a specific reason: proteins, RNA, enzymes, and synthetic peptides degrade quickly under thermal stress, and standard concentrators that rely on heat alone can compromise sample integrity before evaporation finishes. We compared two of the leading refrigerated systems — the Labconco Refrigerated CentriVap and the </strong></span><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2611"><span><strong>Thermo Fisher Refrigerated SpeedVac SRF110</strong></span></a><span><strong> — to see how they stack up for labs where sample preservation is non-negotiable.</strong></span></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://explore.organomation.com/labconco-refrigerated-centrivap-vs-thermo-fisher-refrigerated-speedvac"><span><strong>Download the full comparison with pricing here!</strong></span></a></p></blockquote><h3><strong>The Problem Refrigeration Actually Solves</strong></h3><p>It's a detail that gets lost in most spec-sheet comparisons: running a<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/products?manufacturerItems=540&amp;search=centrivap"><strong> vacuum concentrator </strong></a>without temperature control can cause a sample to over-cool itself. As solvent evaporates under vacuum, the process pulls latent heat from the sample — the same evaporative cooling effect that makes sweat feel cold on skin. For a heat-stable solvent, that's irrelevant. For a temperature-sensitive biomolecule, it can drop the sample low enough to risk unwanted freezing or sublimation mid-run. Labconco's own engineering notes for the Refrigerated CentriVap describe this directly: the unit pairs a refrigeration system with a heater so operators can hold a precise set-point temperature and avoid sublimated samples caused by evaporative cooling. That's the whole reason this product category exists, and it's worth understanding before comparing specs line by line.</p><h3><strong>Price: A Wider Gap at the High End</strong></h3><p>The <strong>Labconco Refrigerated CentriVap</strong> is typically priced around <strong>$13,000 USD</strong>. The <strong>Thermo Fisher SRF110</strong> runs higher, generally<strong> $15,000–$17,000 USD</strong>, and that's before factoring in the modular kit components — Thermo Fisher sells the SRF110 with a separate vacuum system, rotor, vapor trap, and heat transfer fluid bundled into the total kit price. The price gap between these two refrigerated units is proportionally larger than what we found comparing their non-refrigerated counterparts, which makes the value case for the CentriVap even more pronounced at this tier.</p><h3><strong>Capacity: The Difference That Matters Most Right Now</strong></h3><p>This is where the two systems really separate, and it lines up with where lab demand is heading. The Refrigerated CentriVap processes up to <strong>312 samples</strong> per run; the SRF110 tops out at <strong>132</strong>. Both handle volumes up to 50 mL, so this isn't a volume trade-off the way it was in our earlier comparison — it's a straight throughput advantage for the CentriVap.</p><p>That gap matters because<a target="_blank" rel="noopener noreferrer" href="https://peptidestaff.com/industry-trends/peptide-therapy-market-forecast-2026/"><strong> peptide-based therapeutics </strong></a>have become one of the fastest-growing classes of drugs in the pharmaceutical industry, and manufacturing capacity — not demand — is widely cited as the primary bottleneck holding the sector back. <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7541"><strong>GLP-1 programs</strong></a> in particular are pushing <a target="_blank" rel="noopener noreferrer" href="https://www.bachem.com/knowledge-center/glp-1-demand-for-peptide-manufacturers/"><span><strong>peptide manufacturers</strong></span></a><span> </span>toward industrialized, large-scale production platforms rather than one-off batch work. <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/"><strong>Sample prep equipment</strong></a> sits squarely inside that bottleneck: every purification run, HPLC fraction, and concentration step has to scale alongside the chemistry. A concentrator that processes more than double the samples per run, like the Refrigerated CentriVap, is a meaningfully different proposition for a peptide synthesis or purification lab than it would have been five years ago.</p><h3><strong>Temperature Range: How Cold You Can Go</strong></h3><p>The CentriVap's refrigeration reaches as low as<strong> -10°C</strong>; the SRF110 bottoms out at <strong>-4°C</strong>. Both units heat up to +100°C. That six-degree gap on the cold end isn't dramatic on paper, but for the most heat-labile peptides and enzymes, the lower floor gives operators more margin before a sample is at risk — particularly during longer runs where evaporative cooling has more time to compound any thermal load on the sample.</p><h3><strong>Vortex Speed and Mechanical Flexibility</strong></h3><p>The CentriVap offers an adjustable vortex range from <strong>500 to 1,800 rpm</strong>, while the SRF110 runs up to<strong> 1,725 rpm</strong>. The CentriVap's lower floor is the more useful distinction here — fragile, large, or shear-sensitive samples (think intact proteins or larger peptide constructs) sometimes need to run at reduced rotor speed to avoid mechanical stress, and the CentriVap gives operators that headroom on both ends rather than just a ceiling.</p><h3><strong>Lid Material: Visibility vs. Durability</strong></h3><p>The Refrigerated CentriVap uses a <strong>glass lid</strong>, letting operators see into the chamber during a run. The SRF110 uses an <strong>epoxy-coated aluminum lid</strong>, which trades visibility for added durability. For labs running visually distinct sample batches — colored buffers, multiple project codes, HPLC fractions pulled at different time points — the ability to glance at the chamber without interrupting a run has real workflow value, especially in a core facility setting where one instrument serves multiple research groups.</p><h3><strong>What This Means for Core Facilities</strong></h3><p>Shared instrumentation cores feel throughput and cold-temperature constraints differently than a single-PI lab does. A<a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/an-appreciation-for-academic-core-labs"><strong> core running samples from multiple research groups </strong></a>— some doing routine RNA cleanup, others running heat-labile peptide fractions from an HPLC purification step — needs an instrument that won't bottleneck on either axis. The CentriVap's combination of higher per-run capacity and a lower refrigeration floor gives a shared facility more room to serve mixed workloads without forcing every group onto the same conservative settings a less flexible unit would require.</p><h3><strong>Built for the Same Footprint</strong></h3><p>Both units are sized for fume hood placement, with the CentriVap measuring<strong> 15.0 x 27.2 x 13.9 inches </strong>against the SRF110's<strong> 16.62 x 25 x 13.75 inches </strong>— close enough that floor planning isn't a deciding factor either way. Both carry <strong>standard one-year warranties</strong>.</p><h3><strong>The Bottom Line</strong></h3><p>For labs concentrating proteins, RNA, enzymes, or peptide fractions at scale — particularly anyone supporting peptide therapeutic development, where production capacity is already the limiting factor industry-wide — the Labconco Refrigerated CentriVap's combination of higher throughput, lower cold-temperature floor, and lower price makes it the stronger fit. The SRF110 remains a capable option for labs with smaller batch sizes already standardized on Thermo Fisher's modular vacuum ecosystem.</p><p>Organomation distributes the full Labconco CentriVap line, including the Refrigerated and Refrigerated Pro models. Contact our team at sales@organomation.com to talk through rotor configuration, cold trap pairing, and throughput planning for your lab.&nbsp;</p><blockquote><h5><a target="_blank" rel="noopener noreferrer" href="https://explore.organomation.com/labconco-refrigerated-centrivap-vs-thermo-fisher-refrigerated-speedvac"><span><strong>Download the full comparison with pricing here!</strong></span></a></h5></blockquote>

Refrigerated SpeedVac SRF110 vs. CentriVap - Why Sample Capacity Matters More Than Ever for Peptide and Protein Labs

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 14th September 2026? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies </strong>and <strong>Waters Corporation </strong>and posters by <strong>Shimadzu / AOAC </strong>and<strong> Thermo Fisher Scientific / Metabolomics!</strong></p><h3><strong>1. Agilent Technologies: Improved Analysis of Intact Proteins and Peptides by Reversed Phase HPLC Using the Altura Ultra Inert PLRP-S 1000 Å Column</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_altura_ultrainert_column_HPLC_analysis_5994_9322en_agilent_2b3a542647.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Intact protein analysis by reversed-phase HPLC (RP-LC) plays a vital role in quality control for determining the purity of biotherapeutic proteins and improving the identification and quantification of critical quality attributes (CQAs). When coupled to mass spectrometric detection, it allows several things. First, an accurate molecular weight to be determined; second, the identification of variants containing post‑translational modifications (PTMs) and proteoforms; and third, the antibody-to-drug ratio in the case of antibody drug conjugates (ADCs).<sup>1</sup>&nbsp;</p><p>While many RP columns have a silica-based stationary phase to enable broader functionalization, residual acidic silanol groups can interact with basic residues in peptides, proteins, and other biomolecules, resulting in significant peak tailing and loss of chromatographic performance. Polystyrene/divinyl benzene (PS/DVB)-based stationary phases do not contain unintentional adsorption sites. Additionally, larger pore sizes have demonstrated superior chromatographic efficiency through less diffusion restriction into the pore volume and reduction of size exclusion mechanisms, degrading the RP-based selectivity.<sup>2</sup>&nbsp;</p><p>Wide-pore columns like the PLRP-S 1000Å provide an exceptional performance with biomolecules, particularly when combined with MS-compatible mobile phase conditions such as formic acid.&nbsp;</p><p>Even so, some undesirable interactions may be observed when using stainless-steel column hardware. Molecules that possess multiple negative charges (including oligonucleotides, phosphorylated peptides and proteins, and proteins with low isoelectric point in general) may interact with exposed metal ions in stainless-steel column hardware. This can result in the need to "deactivate" new columns by making multiple injections of sample until reproducible results are obtained.&nbsp;</p><p>This application note demonstrates how the new <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=10&amp;search=Altura+Ultra+Inert"><strong>Altura Ultra Inert </strong></a>PLRP-S 1000 Å column serves as an effective high-performance workhorse in the analysis of large, intact biomolecules. Developed to effectively block nonspecific adsorption during separations, Ultra Inert technology reduced passivation time 15-fold and delivered ~ 10% greater recovery for mAbs and ADCs and up to 100% for smaller biomolecules like GLP-1s and small globular proteins.</p><h4><strong>Experimental</strong></h4><h5><strong>Instrumentation&nbsp;</strong></h5><ul><li>Agilent 1290 Multicolumn thermostat (G7116B)&nbsp;</li><li>Agilent 1290 Bio multisampler (G7137A)&nbsp;</li><li>Agilent 1290 Bio high-speed pump (G7132A)&nbsp;</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=10&amp;search=6530"><strong>Agilent 6530 Q-TOF MS system</strong></a>&nbsp;</li></ul><h5><strong>Software and data processing&nbsp;</strong></h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=10&amp;search=MassHunter+Workstation"><strong>Agilent MassHunter Workstation, version 10.1&nbsp;</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=10&amp;search=MassHunter+Qualitative+Analysis"><strong>Agilent MassHunter Qualitative Analysis software, version&nbsp;B.07&nbsp;</strong></a></li><li>Agilent DAR calculator, version B01.01</li></ul><h4><strong>Conclusion&nbsp;</strong></h4><p>Intact mass analysis is a critical methodology to determine the purity of biotherapeutics, but due to the chemical complexity of these analytes, nonspecific adsorption from both silica stationary phase and metal column housing can be highly deleterious to separation performance. The Agilent Altura PLRP-S 1000 Å provides a highly robust solution combining the chemical inertness of polystyrene/divinyl benzene stationary phase with the ultra‑inert Altura hardware to dramatically reduce deleterious peak tailing and increase recovery for biotherapeutics. Herein, we see that analyte recovery for both mAbs, ADCs, GLP-1s, and globular proteins are improved versus stainless-steel, while the Altura PLRP-S column is capable of monitoring both quality critical PTMs such as loss of drug payload as well as accurate quantification of ADC DAR.</p><h3><strong>2. Shimadzu / AOAC: Ambient Ionization Mass Spectrometric Detection of Aroma Released During Gummy Chewing</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/aoac_2026_47_2_34c41f762f.pdf"><strong>Full PDF for download</strong></a></li></ul><p>In recent years, there has been growing interest in evaluating flavor using analytical instrumentation, and retronasal aroma during eating is important. In this study, we proposed an analytical method for measuring retronasal aroma during eating using a single quadrupole mass spectrometer (<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=1&amp;search=2050"><strong>LCMS-2050</strong></a>) equipped with an ambient ion source (Dark Current Discharge Ionization : DCDI) without pretreatment.</p><h4><strong>Conclusion</strong></h4><p>We developed a simple method for evaluating retronasal aroma using a single quadrupole mass spectrometer with an ambient ionization source. Ambient ionization mass spectrometry (DCDI LCMS-2050) can rapidly measure retronasal aroma during eating. Time-resolved visualization reveals texture-dependent differences in aroma release dynamics among grape-flavored gummies. It is also expected to lead to the visualization of the marriage between food and alcohol. This approach may facilitate objective evaluation of flavor release during consumption and support product formulation and sensory science.</p><h3><strong>3. Thermo Fisher Scientific / Metabolomics: Orbitrap Tribrid Real-Time similarity searching of mzCloud library for guided unknown characterization of tea metabolites</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/po_004849_lsms_rtls_tribrid_apex_small_molecule_metabolomics_po004849_na_en_d0d3156065.pdf"><strong>Full PDF for download</strong></a></li></ul><p>In metabolomics LC-MS data is processed to generate a list of detected compounds with a level of confidence in the identity of each compound based on reference data. This reference data may be spectral data and/or retention time information stored in a library or in silico information generated based on fragmentation rules. These annotated compounds are then used to evaluate biological changes between normal and disease states. One of the major hurdles between collected data and coming to reliable conclusions about the biology is the limited number of standards available to build these libraries. It is common to have hundreds to thousands of compounds detected in a data set that have no library match because there is no commercial standard for that unknown. Instead, there is just an elemental formula and matches from a structure database. These structures can be compared using in silico fragmentation techniques to determine which isomers plausibly match the data. MSn data can help reduce the list of possible matches, but without guidance, ddMS3 may not consistently collect data on the most relevant MS2 fragments to accomplish this.&nbsp;</p><p>In this work we use Real-Time Library Search (RTLS) in a ddMS3 method to help guide the instrument in real time to collect the most relevant data for confirming structural matches.</p><h4><strong>Materials and methods</strong></h4><h5><strong>Test method(s)&nbsp;</strong></h5><p>1 μL aliquots were analyzed using a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/products?category=48&amp;manufacturerItems=3&amp;search=gold"><strong>Thermo Scientific Hypersil GOLD column</strong></a> on a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/744"><strong>Thermo Scientific Vanquish Horizon UHPLC</strong></a><strong> </strong>coupled with a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/561"><strong>Thermo Scientific Orbitrap IQ-X Tribrid mass spectrometer</strong></a> and <strong>Thermo Scientific Orbitrap Tribrid Apex Small Molecule mass spectrometer</strong>. RTLS was run in similarity mode using the offline version of <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1764"><strong>Thermo Scientific mzCloud library</strong></a>.&nbsp;</p><h5><strong>Data analysis&nbsp;</strong></h5><p>Data was processed using <strong>Thermo Scientific Freestyle and </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1759"><strong>Compound Discoverer software</strong></a><strong>.</strong></p><h4><strong>Conclusions&nbsp;</strong></h4><p>Tea extracts were analyzed using RTLS to find the most similar compound in the offline version of the mzCloud library and trigger MS3 on the highest m/z matching and non-matching fragments. This provided additional information to confirm similarity and provide insight on shared sub-structures to the library compound as well as additional information on the portions of the structure that were unique to the experimental compound.</p><h3><strong>4. Waters Corporation: The Quantification of Glucagon-like Peptide Receptor Agonists (GLP-1 RAs) in Plasma Extracts Using Capillary UHPLC-MS/MS</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/720009537_en_0068921516.pdf"><strong>Full PDF for download</strong></a></li></ul><div><div><section><div><div><div><div><div><div><h5><strong>Benefits&nbsp;</strong></h5><ul><li>10-fold improvement in sensitivity&nbsp;</li><li>Robust methodology for &gt;500 injections&nbsp;</li><li>Reduced solvent usage&nbsp;</li><li>No need for complex nanospray MS source</li></ul><p>Obesity represents, perhaps, the largest healthcare challenge, affecting approximately 1.3 billion people globally, contributing to a diverse range of chronic diseases e.g., metabolic, cardiovascular, muscular skeletal, and multiple cancers.1 The rapid growth of obesity and associated global healthcare costs means there is a critical need for safe effective treatments.2 GLP-1 RA initially developed for type 2 diabetes have shown clinical efficacy as weight loss medicines.2 These drugs mimic the action of gut hormones which regulate energy metabolism and appetite by interacting with the hypothalamus, brain stem etc., resulting in weight loss. The success of these GLP-1 RAs is associated with their on-target efficacy and long duration of action,3 e.g., half-life of semaglutide t½ = 160–180 hours3 cf. 1–2 minutes for human GLP-1.4 The long half-life of these GLP-1 RAs results in low, sub ng/mL plasma levels 48–72 hours after dosing, which requires a high sensitivity bioanalytical assay to accurately quantify the plasma concentrations5 and define the PK elimination phase.&nbsp;</p><p>Tandem quadrupole electrospray ionization (ESI) mass spectrometry, operated in multiple reaction monitoring (MRM) mode, coupled with 2.1 mm ID ultra-high performance liquid chromatography (UHPLC) is the dominant technology platform for quantitative bioanalysis. As next generation GIP/GLP-1 RAs promise to be more potent, resulting in lower dosing levels and plasma levels, there is a need for more sensitive analytical methodologies to support drug metabolism and pharmacokinetics (DMPK) studies. Capillary/nano LC-MS/MS have been extensively employed in proteomics to increase analytical sensitivity and enable small volume analysis.5 This sensitivity increase is derived from a combination of the superior ionization efficiency at low flow rates and analyte concentration due to the smaller column geometry.6 This application note illustrates the use of capillary (300 µm) UHPLC-MS/MS (MRM) to affect 10-fold improvement in GLP-1-RAs peak response in human plasma extracts, and detection limits as low as 20 pg/mL for tirzepatide.</p><h4><strong>Experimental</strong></h4><p>Capillary chromatography was performed on an <strong>ACQUITY™ M-class Chromatography System</strong> connected to a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/195"><strong>Xevo™ TQ-XS Mass Spectrometer</strong></a> (Waters Corporation, Wilmslow, UK) equipped with a microflow probe. Capillary UHPLC separations were performed on an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1952"><strong>ACQUITY Premier Peptide CSH C18</strong></a>, 300 Å, 1.7 µm, 300 µm x 50 mm Chromatography Column.</p><p>MS analysis was performed at unit mass resolution using positive ESI at a capillary voltage of 3.0 kV, with a cone voltage of 32 V. The cone gas flow, desolvation gas flow, and desolvation gas temperature were 50 L/h, 300 L/h and 600 °C, respectively. The data were analyzed using <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1544"><strong>waters_connect™ Software</strong></a><strong>,</strong> and MRM transitions used to monitored for the MS/MS detection of liraglutide, exenatide, semaglutide and tirzepatide were as follows: liraglutide 938.7 → 1128.4, exenatide 838 → 396, semaglutide 1029.2 → 1238.1, and tirzepatide 1204.2 → 396.2. Data analysis was performed using <strong>MS Quan Software.</strong></p><h4><strong>Conclusion</strong></h4><p>Bioanalysis plays a critical role in the drug discovery and development processes providing data to support DMPK, safety assessment, pharmacokinetics/pharmacodynamics (PK/PD), and clinical development studies. The development of new, more potent medicines, innovating delivery platforms, micro sampling, and new approach methodologies (e.g., organ on a chip) all require greater levels of analytical sensitivity. Capillary scale UHPLCMS/MS offers the potential to improve bioanalytical detection limits up to 10-fold, without the need for long analysis times and complex operation associated with nano spray LC-MS/MS. Here, the application of capillary (300 µm ID) scale chromatography for the detection of GLP-1 RAs in human plasma extracts at levels as low as 20 pg/mL with robustness over 500 injections was demonstrated.</p></div></div></div></div></div></div></section></div></div>

News from LabRulezLCMS Library - Week 38, 2026

Article

Product

Application

Science and research

Poster

Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Thermo Scientific™ Vanquish™ Neo UHPLC System

Take advantage of outstanding performance and productivity for all LC-MS workflows with nano-, capillary, and microflow using the Thermo Scientific™ Vanquish™ Neo UHPLC system.

Thermo Scientific Orbitrap Exploris 480 Mass Spectrometer

Empowering life science researchers to translate each experimental step to a new level of insight with built-in workflows and single-cell sensitivity.

<p><strong>Empowering life science researchers to translate each experimental step to a new level of insight with built-in workflows and single-cell sensitivity. Accelerate your path to impactful results with a next-generation ownership experience coupled with an intelligence-driven experimental approach. Achieve a new standard in performance to study trace samples with extraordinary accuracy, certainty, confidence and simplicity. You'll find market leading quantitative performance to solve your most complex challenges with ease, and the proven qualitative performance you expect from Orbitrap- based mass spectrometry.</strong></p><p>From exploratory to targeted quantitation, find the power and reliability to make large scale studies possible, while reducing everyday hassles as you increase productivity. And achieving it all, remarkably, within a compact footprint. An extraordinary instrument, providing extraordinary results; the Thermo Scientific Orbitrap Exploris 480 mass spectrometer.</p><h4><strong>Key benefits of the Orbitrap Exploris 480 mass spectrometer</strong></h4><h5><strong>Next-generation experience</strong></h5><p>Built with next-generation common hardware and software architecture, the guiding principle of ultimate performance and ease of use delivers effortless access to the value contained within your data.</p><h5><strong>High performance, high-throughput insights</strong></h5><p>Adding greater performance and intelligence to market-leading selectivity and spectral quality imparts productivity, depth, and certainty to small and large- scale studies.</p><h5><strong>Robust performance and exceptional serviceability increase uptime</strong></h5><p>By design, exceptional end-to-end robustness minimizes need for performance-related maintenance, increasing uptime and sample throughput.</p><h5><strong>Ease-of-use and intelligence to empower all users</strong></h5><p>Differences in user expertise can be a challenge in many laboratories. Workflows based on intelligent data acquisition methods leverage new levels of instrument performance to deliver high confidence, and high throughput.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Ion_path_and_key_components_of_the_Orbitrap_Exploris_480_mass_spectrometer_3f5791378c.webp" alt="Thermo Fisher Scientific: Ion path and key components of the Orbitrap Exploris 480 mass spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Ion_path_and_key_components_of_the_Orbitrap_Exploris_480_mass_spectrometer_3f5791378c.webp 245w," sizes="100vw" width="950" height="410"></p><div><h4><strong>How does the Orbitrap Exploris 480 MS enable greater data insights faster?</strong></h4></div><div><p>See what makes the Orbitrap Exploris 480 MS stand out, how it can empower all users to obtain the highest quality results and deepest insights with the least amount of effort; see how our breakthrough is now your breakthrough.</p></div><ul><li><strong>Next-Generation Instrument Design</strong></li><li><strong>Targeted Protein Quantitation Workflows with SureQuant IS</strong></li><li><strong>Advancing Accuracy, and Precision in Quantitative Proteomics through Multiplexing</strong></li><li><strong>Sub 1-ppm Mass Accuracy as Standard</strong></li><li><strong>Improved Performance through Instrument Enhancements</strong></li><li><strong>Intelligence-Driven Instrument Set-Up, Control and Data Acquisition</strong></li><li><strong>Visualize the Orbitrap Exploris Data Acquisition Modes</strong></li></ul><h4><strong>Optional features to maximize performance</strong></h4><p>Maximize performance and flexibility to expand experimental capabilities of the Orbitrap Exploris 480 mass spectrometer with multiple hardware and software options, allowing you to see more, quantify more, deliver more confidence and greater insights with even more productivity.</p><ul><li><strong>Enhance your Experimental Performance with the FAIMS Pro Duo interface</strong></li><li><strong>Comprehensive and confident biotherapeutic characterization</strong></li></ul><div data-uw-styling-context="true"><h4><strong>Data analysis made easy</strong></h4></div><div data-uw-styling-context="true"><p data-uw-styling-context="true">From complex proteomic challenges, quantitation with SureQuant and TMT multiplexing, through to complete biotherapeutic characterization, data analysis doesn’t have to be the bottleneck to accessing deeper insights into your high-quality MS data. Despite the numerous workflows involved in the analysis of proteins, there are flexible analysis tools which allow simple, yet confident, interpretation of your data to streamline your research and facilitate decision making to take your research to the next level.</p></div><ul><li><strong>Flexibly Identify and Quantify Proteins Based on your Workflow</strong></li><li><strong>The Right Path Towards Complete Biotherapeutic Characterization</strong></li><li><strong>Compliance and Enterprise Readiness with Chromeleon CDS Software</strong><br>&nbsp;</li></ul>

Thermo Scientific Orbitrap Exploris 240 Mass Spectrometer

Maximize performance and flexibility to expand your experimental capabilities, allowing you to discover more, see more, quantify more, and deliver more confidence and greater insights with even more productivity.

<div container-id="cq-colctrl-lt8" comp-id="B2"><div><p><strong>Maximize performance and flexibility to expand your experimental capabilities, allowing you to discover more, see more, quantify more, and deliver more confidence and greater insights with even more productivity.</strong></p><p>Deliver on your objectives with performance to drive discovery and identification, plus receive the quantitative precision and accuracy you need to confidently scale up and achieve impact. With operational simplicity through intelligent data acquisition and processing, discover your fast track to confident results regardless of sample complexity, the depth of insights required or the presence of unknown compounds.</p><h4><strong>Application capabilities through instrument versatility</strong></h4><p>Maximize performance and flexibility to expand your experimental capabilities, allowing you to discover more, see more, quantify more, and deliver more confidence and greater insights with even more productivity.</p><ul><li><strong>Confident and comprehensive proteomic analyses</strong></li><li><strong>Translational proteomics: Scaling translational discoveries into reliable clinical applications</strong></li><li><strong>Comprehensive biotherapeutic characterization: Maximize biotherapeutic insights&nbsp;</strong></li><li><strong>Intact native mass analysis: Maximize biotherapeutic insights&nbsp;</strong></li><li><strong>Metabolomics workflows: One solution for all metabolics workflows&nbsp;</strong></li><li><strong>Clinical research: Translate qualitative and quantitative assays into future clinical applications</strong></li><li><strong>Food/beverage and environmental analyses: Fast-track to results with confidence&nbsp;</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Thermo_Scientific_Orbitrap_Exploris_240_Mass_Spectrometer_a4d2d7771c.jpg" alt="Thermo Fisher Scientific: a) Quantitative experimental design for the analysis of a control and three knockout (KO) strains. b) The orthogonality of the FAIMS Pro interface shows improved peptide coverage when using a range of different CVs. c) Intensity ranking across five orders of quantitative dynamic range for the peptide spectrum matches provided by Proteome Discoverer software. d) Quantitative ratios for each of the samples, highlighting the relative abundance of the KO proteins." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Thermo_Scientific_Orbitrap_Exploris_240_Mass_Spectrometer_a4d2d7771c.jpg 245w," sizes="100vw" width="1000" height="543"></p><div><h4><strong>Key benefits of the Orbitrap Exploris 240 mass spectrometer</strong></h4></div><div><p>Delivering actionable insights faster than ever before by combining proven benefits of Thermo Scientific Orbitrap technology, with sub 1-ppm mass accuracy and high resolution, with intelligent data acquisition and processing.</p></div><h5><strong>Everyday experimental flexibility</strong></h5><p>Discover workhorse versatility from confident proteomic and small-molecule identification and quantitation to biopharmaceutical characterization and in-depth sample-profiling.</p><h5><strong>Faster path to confident insights</strong></h5><p>Delivering actionable insights faster than ever before by combining proven benefits of Thermo Scientific Orbitrap technology, such as sub 1-ppm mass accuracy and high resolution, with intelligent data acquisition and processing.</p><h5><strong>Reliable, robust, and maintainable</strong></h5><p>Meet an exceptional system every day, one with versatility and operational simplicity, but that doesn’t compromise robustness and reliability so you can be confident in its ability to perform on long-term studies.</p><h5><strong>Focus on driving results with faster setup</strong></h5><p>Fully integrated instrument control, setup, and data processing, helps you focus on delivering actionable results while single-system calibrations and pre-defined method templates drive productivity.</p><blockquote><h5><strong>Top reasons to choose Orbitrap Exploris 240 MS over Q-TOF instrumentation</strong></h5><p>Others claim to set new standards in proteomics. Is Protein ID without quantitation sufficient for shotgun proteomics to provide biological insights? Meet the Orbitrap Exploris 240 mass spectrometer – with leading quantitative performance, sensitivity and versatility, designed to meet your needs.</p><p>Trust us to deliver technology innovations that are foundations of reliable workflows and solutions, along with publishable and actionable results.</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/products-and-services/promotions/industrial/10-reasons-choose-orbitrap-exploris-over-qtof.html"><span><strong>Learn more</strong></span></a></li></ul></blockquote><h4><strong>Data Analysis with connectivity to drive productivity</strong></h4><p>From complex proteomic challenges, complete biotherapeutic characterization, or small-molecule discovery to everyday testing, data analysis is your gateway to accessing deeper insights into your high-quality MS and MS2 data. Despite the numerous workflows involved, there are flexible analysis tools for simple, confident interpretation of your data to streamline research and facilitate rapid decision making.</p><ul><li><strong>Flexibly identify and quantify proteins based on your workflow</strong></li><li><strong>Biopharmaceutical characterization with BioPharma Finder software</strong></li><li><strong>Streamline your small-molecule qualitative and quantitative assays</strong></li><li><strong>Small-molecule characterization with Compound Discoverer software</strong></li><li><strong>Complete screening and quantitation using Thermo Scientific TraceFinder software</strong></li><li><strong>Complete compliant control with Chromeleon CDS for MS</strong></li></ul></div></div>

Thermo Scientific Orbitrap Exploris 120 Mass Spectrometer

With its unique ability to provide consistently accurate data and a design made for operational simplicity, it sets the new standard in instrument productivity and ruggedness.

<p><strong>The proven Thermo Scientific Orbitrap technology in the Thermo Scientific Orbitrap Exploris 120 mass spectrometer accelerates your route to qualitative and quantitative confidence for both method development and everyday testing purposes. With its unique ability to provide consistently accurate data and a design made for operational simplicity, it sets the new standard in instrument productivity and ruggedness.</strong></p><h4><strong>Key benefits of the Orbitrap Exploris 120 mass spectrometer&nbsp;</strong></h4><h5><strong>Confidently perform high-throughput qualitative and quantitative analysis</strong></h5><p>Spend less time questioning your results with the unique ability of Orbitrap high-resolution, accurate-mass spectrometers (HRAM) to provide accurate results and reduce false positives or negatives. Confidently resolve ions of interest from interfering ions with high mass resolution up to 120,000 at m/z 200 for both method development and everyday testing analyses.</p><h5><strong>Keep your laboratory running seamlessly with the new standard in instrument ruggedness</strong></h5><p>Maximize return on your investment with capabilities that minimize downtime. Perform a single, stable calibration for the entire mass range from m/z 40-3000. With an improved scan rate up to 22 Hz, maximize your compound coverage with confidence. The ability to do both positive and negative mode switching ensures you analyze twice as many analytes in the same sample.</p><h5><strong>Focus on driving results with faster method set-up</strong></h5><p>Empower high-resolution MS users by giving them the ability to analyze samples using ready-to-run method templates. Minimize time spent on software training for Thermo Scientific MS users with a common software user interface for data acquisition.</p><h4><strong>How the Orbitrap Exploris 120 MS works</strong></h4><p>Discover how the Orbitrap Exploris 120 MS instrument enables you to prioritize your time on making critical decisions which impact the future of you or your client's organization. The latest instrument capabilities have been designed with the sole purpose of putting you on the fast path to accurate, reportable results. Leave the lab at the end of the day feeling productive and accomplished.</p><ul><li><strong>Uncover and quantify more suspect analytes</strong></li><li><strong>Sub-ppm mass accuracy as standard</strong></li><li><strong>System to system consistency</strong></li><li><strong>Robust performance</strong></li><li><strong>Maximize compound coverage with faster scan rates&nbsp;</strong></li><li><strong>Analyze samples twice as fast with rapid polarity switching&nbsp;</strong></li><li><strong>Intelligence-driven instrument setup, control and data acquisition&nbsp;</strong></li><li><strong>Quantitation: Which scan modes do I use on the instrument?</strong></li><li><strong>Take a video tour&nbsp;</strong></li></ul><div><h4><strong>Data analysis software: Streamline small molecule qualitative and quantitative assays</strong></h4></div><div><p>Connecting small molecule unknown identification and characterization through to screening and quantitation doesn’t just stop at data acquisition across multiple platforms. Now that you have acquired comprehensive, high-quality MS and MS<sup>2</sup> data, you need to identify and characterize unknowns and transfer discovery knowledge through to every day testing.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Which_data_analysis_software_is_right_for_you_30a173dd7f.jpg" alt="Thermo Fisher Scientific: Which data analysis software is right for you?" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Which_data_analysis_software_is_right_for_you_30a173dd7f.jpg 213w," sizes="100vw" width="1385" height="1016"></p><p>Our connected data processing software ecosystem streamlines interpretation of your high-confidence discovery data through powerful Thermo Scientific Compound Discoverer software with direct access to the world’s largest LC-MS<sup data-uw-styling-context="true">n</sup> reference spectral library, Thermo Scientific&nbsp;mzCloud, or through utilization of offline or proprietary libraries. These libraries act as your knowledge repository and allow direct transfer through to everyday screening and quantitation using Thermo Scientific&nbsp;TraceFinder software.</p><ul><li><strong>mzCloud Mass Spectral Library</strong></li><li><strong>Small molecule characterization with Compound Discoverer software</strong></li><li><strong>Complete screening and quantitation using TraceFinder software</strong></li><li><strong>Complete compliant control with Chromeleon CDS for MS</strong></li></ul><h4><strong>Common applications for Orbitrap Exploris 120 Mass Spectrometer</strong></h4><p>To perform method development and everyday testing with confidence, you need a liquid chromatography mass spectrometry (LC-MS) workflow solution that is relevant to your laboratory’s goals. The Orbitrap Exploris 120 MS instrument can be used for a variety of applications, including clinical research, environmental and food safety, forensic toxicology, and pharmaceutical analysis.</p><ul><li><strong>Clinical Research</strong></li><li><strong>Forensic Toxicology</strong></li><li><strong>Drug Screening and Confirmation</strong></li><li><strong>Environmental Emerging Contaminants</strong></li><li><strong>Pesticide Residues Analysis</strong></li><li><strong>Veterinary Drugs Residues Analysis</strong></li><li><strong>Pharmaceutical applications</strong></li></ul></div>

Thermo Scientific TSQ Altis Plus Triple Quadrupole Mass Spectrometer

Overcome quantitative workflow challenges with the TSQ Altis Plus MS, which ensures superior speed, sensitivity, and precision for low-level detection in complex matrices.

<p class="cke-user_style-important"><strong>Advance quantitative workflows and increase productivity</strong></p><p><strong>Address current and future challenges with Thermo Scientific TSQ Plus triple quadrupole mass spectrometers, which provide enhanced acquisition speed/sensitivity, proven robustness, and reliability. Instrument choices offer features for a range of applications, from everyday targeted quantitation to cutting-edge research.</strong></p><h2><strong>TSQ Altis Plus Triple Quadrupole Mass Spectrometer</strong></h2><h3><strong>Ultimate quantitative performance made possible</strong></h3><p>Overcome the most demanding quantitative workflow challenges. With superior <strong>acquisition speeds, enhanced sensitivity, prototypical selectivity</strong>, and <strong>exceptional robustness</strong>, the <strong>TSQ Altis Plus mass spectrometer </strong>delivers unprecedented accuracy and precision <strong>for low-level compound detection</strong> and <strong>quantitation in complex matrices </strong>that redefines ultimate instrument performance.</p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Altis_Plus_Triple_Quadrupole_Mass_Spectrometer_3_dddb4870a2/Thermo-TSQ-Altis-Plus-Triple-Quadrupole-Mass-Spectrometer-3.jpg" alt="Thermo Scientific TSQ Altis Plus Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Altis_Plus_Triple_Quadrupole_Mass_Spectrometer_3_dddb4870a2/thumbnail_Thermo-TSQ-Altis-Plus-Triple-Quadrupole-Mass-Spectrometer-3.jpg 156w," sizes="100vw" width="650" height="650"></figure><div><h2><strong>Highlights</strong></h2></div><div colctrl-id="2-1"><div><div container-id="cq-colctrl-lt7" comp-id="A1"><div><h3 style="text-align:left;"><strong>Achieve the highest confidence in targeted compound detection and quantitation through leading sensitivity&nbsp;</strong></h3><p>Greater than <strong>6 orders</strong> of linear dynamic range with high selectivity. Enhanced acquisition speeds empower large-scale studies for translational workflow development or method optimization with effective dwell time settings as low as <strong>0.3 milliseconds — 5 millisecond</strong> polarity switching maximizes productivity in fewer experiments.</p><p>Where data confidence is required, the instrumental features on the TSQ Altis Plus triple quadrupole mass spectrometer drive high-performance targeted experiments for complex matrices.</p><div colctrl-id="3-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h3><strong>High-throughput screening and quantitation</strong></h3><p>Innovations in the ion source, mass analyzer, active <strong>Q2 collision cell</strong>, and <strong>RF electronics </strong>offer high sensitivity, selectivity, and superior acquisition speeds/polarity switching times that are ideal with ultra-high performance liquid chromatography (UHPLC) separations. With scheduled SRM acquisition and<strong> 600 SRMs/second</strong>, <strong>1000’s of compounds</strong> can be screened or quantified per method. Fast data acquisition reaches the number of required data points for outstanding confidence at extremely low concentrations, in the most challenging matrices.</p></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h3><strong>Expanded experimental capabilities</strong></h3><p>Integrated workflow solutions centered on the TSQ Altis Plus mass spectrometer address regulated requirements targeting a growing list of diverse compounds. New UHPLC and ion chromatography (IC) systems maximize sample delivery and separation capabilities, maintaining the sensitivity to meet minimum residue limits without costly sample preparation or derivatization steps. <strong>Thermo Scientific Chromeleon Chromatographic Data System</strong> (CDS) software controls all experimental attributes in a regulated environment to further drive productivity.</p></div></div></div></div><div colctrl-id="4-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Altis_Plus_Triple_Quadrupole_Mass_Spectrometer_4_bc3264af33/Thermo-TSQ-Altis-Plus-Triple-Quadrupole-Mass-Spectrometer-4.jpg" alt="Thermo Scientific TSQ Altis Plus Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Altis_Plus_Triple_Quadrupole_Mass_Spectrometer_4_bc3264af33/thumbnail_Thermo-TSQ-Altis-Plus-Triple-Quadrupole-Mass-Spectrometer-4.jpg 156w," sizes="100vw" width="650" height="650"></figure><h3><strong>Operational simplicity</strong></h3><p>Targeted research and routine applications demand fast and responsive instrument control software, with intuitive operations. Simplified calibration approach consolidates steps needed by the operator, combining an intelligent instrument check and calibration routine. <strong>Direct method transfer </strong>from the previous generation Thermo Scientific TSQ mass spectrometers can be performed for equal or better performance <strong>without optimization</strong>.</p><p>Experimental determination of dwell times assigned to each transition has been automated based on user-defined chromatographic peak width and the option of fixed cycle time or optimal number of data points per chromatographic peak.&nbsp;Prioritization settings allow further adjustments.</p></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h3><strong>Database integration</strong></h3><p>Method development for targeted acquisition methods requires a prior knowledge of optimal product ions and energetics. Utilization of <strong>experimental libraries </strong>created from discovery experiments can by-pass the need for purified standards and lengthy optimization routines. The output from processed data in <strong>Thermo Scientific TraceFinder software</strong> can be directly imported into the instrument method editor, streamlining large-scale study creation.</p><p>Discovery experiments, however, may not contain all compounds targeted in a study. Integration with <strong>Thermo Scientific mzCloud databases</strong> enables selection of additional compounds from the most advanced mass spectral database to be added into existing experimental methods.</p></div></div></div></div></div></div></div></div>

Thermo Scientific™ Dionex™ Aquion™ Ion Chromatography (IC) System

Perform basic anion or cation analyses reliably with Dionex™ Aquion™ IC system bundles that include hardware, software, and consumables for easy ordering.

<h4><strong>Reliable, budget-friendly ion chromatography for routine anion and cation analysis</strong></h4><p>Simplify ion analysis in your laboratory with the <strong>Dionex™ Aquion™ IC system</strong>, a compact and easy-to-operate platform designed for routine applications in <strong>environmental, food safety, and academic labs</strong>. Ideal for budget-conscious operations, the Aquion system delivers dependable performance, quick startup, and low operating costs.</p><h3><strong>Key system features</strong></h3><ul><li><strong>Chemically inert PEEK flow path</strong></li><li><strong>Serial dual-piston pump</strong><ul><li>Flow rate: 0.01–5.0 mL/min</li><li>Pressure: up to 5000 psi</li></ul></li><li><strong>High-pressure pulse dampener</strong></li><li><strong>Electrically actuated, PEEK, 6-port Rheodyne injection valve</strong></li><li><strong>Conductivity detection with digital signal processing</strong><ul><li>Range: 0–15,000 μS</li><li>Temperature-controlled conductivity cell for signal stability</li></ul></li><li><strong>Support for electrolytic or chemical suppressors</strong></li><li><strong>Optional column heater</strong></li><li><strong>Built-in inline vacuum degasser</strong></li></ul><h3><strong>Benefits of electrolytic suppression</strong></h3><ul><li>Lower background conductivity and reduced detection limits</li><li>Faster system startup</li><li>Superior sensitivity for both anion and cation analysis</li><li>No need for manual regenerant preparation</li></ul><h3><strong>Optimized detection with conductivity</strong></h3><p>The Aquion system is optimized for conductivity detection using a <strong>thermostated high-performance cell</strong> that ensures stability against ambient temperature fluctuations. Digital signal control offers a wide dynamic range for simultaneous detection of analytes with varying concentrations.</p><h3><strong>Seamless control with Chromeleon™ CDS software</strong></h3><p>Included in every system bundle, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS)</strong></a> software provides intuitive instrument control, automated workflows, and streamlined data handling:</p><ul><li><strong>eWorkflows</strong>: auto-load instrument conditions and processing templates</li><li><strong>Calibration Wizard</strong>: step-by-step guidance for method setup and quantification</li><li><strong>Wellness Trending</strong>: monitor system performance over time for predictive maintenance</li></ul><h3><strong>Anion and Cation System Bundles</strong></h3><p>Each bundle includes everything needed to get started:</p><h4><strong>Included in all system bundles:</strong></h4><ul><li>Dionex Aquion IC System with power cable</li><li>Dionex Aquion Analysis Kit (anion or cation specific)</li><li>Chromeleon SE software and license</li><li>3-year warranty (parts-only coverage in years 2 and 3)<br>→ Optional extended warranty available including labor and travel in years 2 and 3</li></ul><h4><strong>Anion Analysis Kit includes:</strong></h4><ul><li><strong>Dionex IonPac AG22 (4 × 50 mm) guard column</strong></li><li><strong>Dionex IonPac AS22 (4 × 250 mm) analytical column</strong></li><li><strong>Dionex AERS 500 Carbonate (4 mm) suppressor</strong></li><li><strong>Combined Seven Anion Standard II</strong><br><i>Note: Eluent concentrate must be ordered separately.</i></li></ul><h4><strong>Cation Analysis Kit includes:</strong></h4><ul><li><strong>Dionex IonPac CG12A (4 × 50 mm) guard column</strong></li><li><strong>Dionex IonPac CS12A (4 × 250 mm) analytical column</strong></li><li><strong>Dionex CDRS 600 (4 mm) suppressor</strong><br><i>Note: Eluent concentrate and standards must be ordered separately.</i></li></ul><h3><strong>Why choose Dionex Aquion?</strong></h3><ul><li>Proven IC platform with straightforward operation</li><li>Reliable results and stable performance</li><li>Full compatibility with standard and microbore column formats (2–5 mm)</li><li>Low cost of ownership with high-quality support and service</li><li>Ideal entry point for labs new to ion chromatography</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Dionex_Aquion_Iontovy_Chromatograf_2_8c661a76f1/Thermo-Dionex-Aquion-Iontovy-Chromatograf-2.jpg" alt="Thermo Scientific™ Dionex™ Aquion™ Ion Chromatography (IC) System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Dionex_Aquion_Iontovy_Chromatograf_2_8c661a76f1/thumbnail_Thermo-Dionex-Aquion-Iontovy-Chromatograf-2.jpg 156w," sizes="100vw" width="650" height="650"></p>

Thermo Scientific Dionex Integrion HPIC System 

Achieve versatile and efficient separations that meet your routine ion analysis demands with the reliable Thermo Scientific Dionex Integrion HPIC system. 

<div><div id="container-9240b945f2"><div><div id="title-b4d119a2b1"><h3 data-uw-rm-heading="level" role="heading" aria-level="2"><strong>Dionex Integrion HPIC System: An easy solution for routine analysis</strong></h3></div></div><div><div id="container-2c24fcced5"><div><div id="text-1819779492"><p><strong>Achieve versatile and efficient separations that meet your routine ion analysis demands with the reliable Thermo Scientific Dionex Integrion HPIC system. Its high-pressure ion chromatography (HPIC) capabilities enable faster analysis without compromising data quality. The Dionex Integrion&nbsp;HPIC system is designed for routine&nbsp;ion chromatography (IC) applications for water, food and beverage, biofuels and pharmaceutical analysis.</strong></p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Dionex_Integrion_Iontovy_Chromatograf_2_7a7f2ce86a/Thermo-Dionex-Integrion-Iontovy-Chromatograf-2.jpg" alt="Thermo Scientific Dionex Integrion HPIC System " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Dionex_Integrion_Iontovy_Chromatograf_2_7a7f2ce86a/thumbnail_Thermo-Dionex-Integrion-Iontovy-Chromatograf-2.jpg 156w," sizes="100vw" width="650" height="650"></figure></div></div></div></div></div></div><div><div id="container-ee4e409cf5"><div><div id="sectiontitle-d7eca6bc0f"><h3><strong>Highlights</strong></h3></div></div><div><div id="container-94710c6880"><div><div><div id="container-006293a352"><div><div><div id="text-328176320"><h4><strong>Simple plumbing layout</strong></h4><p><strong>The plumbing layout </strong>of this high-pressure ion chromatography system is based on a logical flow path for <strong>easy component access</strong> in a compact platform with a small physical footprint.</p></div></div></div></div></div><div><div id="container-9133f3a75a"><div><div><div id="text-1491634964"><h4><strong>Inert, reliable components</strong></h4><p><strong>Inert, nonmetallic PEEK components</strong> throughout the <strong>Dionex Integrion HPIC system </strong>ensure <strong>compatibility with corrosive eluents and analyses free from metal contamination.</strong> Easy-to-install<strong> IC PEEK Viper fittings</strong> have <strong>low dead volume</strong> and require no special training or tools.</p></div></div></div></div></div><div><div id="container-1d936b69ba"><div><div><div id="text-644579526"><h4><strong>Wide range of IC columns</strong></h4><p>The Dionex Integrion HPIC system is<strong> compatible with a wide variety of column sizes,</strong> including<strong> smaller-particle-size 4 µm columns for HPIC capabilities, </strong>which provide faster run times and better resolution, to meet the requirements of your applications. &nbsp;</p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Dionex_Integrion_Iontovy_Chromatograf_3_bf2f665361/Thermo-Dionex-Integrion-Iontovy-Chromatograf-3.jpg" alt="Thermo Scientific Dionex Integrion HPIC System " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Dionex_Integrion_Iontovy_Chromatograf_3_bf2f665361/thumbnail_Thermo-Dionex-Integrion-Iontovy-Chromatograf-3.jpg 156w," sizes="100vw" width="650" height="650"></figure></div></div></div></div></div><div><div id="container-f643098693"><div><div><div id="text-1278873072"><h4><strong>Automated Eluent Generation (EG)</strong></h4><p>Optional <strong>Reagent-Free Ion Chromatography</strong> with Eluent Generation (RFIC-EG) combines<strong> automated eluent generators and electrolytically regenerated suppressors</strong> to create eluents and regenerants.</p></div></div></div></div></div></div></div></div><div><div id="container-1021b10e17"><div><div><div id="container-a6d8f5fdb8"><div><div><div id="text-1022646706"><h4><strong>Flexible detector options</strong></h4><p>The Dionex Integrion HPIC system allows for easy, swappable integration with either a <strong>conductivity detector</strong> <strong>(CD)</strong> or an <strong>electrochemical detector (ED)</strong>. The system is also compatible with<strong> various external detectors</strong>, including a <strong>mass spectrometer (MS) </strong>or a<strong> variable wavelength detector (VWD).</strong></p></div></div></div></div></div></div></div></div><div><div id="container-cd507ea43e"><div><div><div id="container-3bdbc48a4f"><div><div><div id="text-1802479128"><h4><strong>CDS Software</strong></h4><p>The Dionex Integrion HPIC system comes with the easy-to-use <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Thermo Scientific Chromeleon Chromatography Data System (CDS)</strong></a><strong>.</strong> This software platform provides powerful control and data processing for IC and offers eWorkflows that make all our essential applications easily accessible.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Dionex_Integrion_Iontovy_Chromatograf_a_ICS_4000_c7b3adbeea/Pragolab-Thermo-Dionex-Integrion-Iontovy-Chromatograf-a-ICS-4000.jpg" alt="Thermo Scientific Dionex Integrion HPIC System " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Dionex_Integrion_Iontovy_Chromatograf_a_ICS_4000_c7b3adbeea/thumbnail_Pragolab-Thermo-Dionex-Integrion-Iontovy-Chromatograf-a-ICS-4000.jpg 236w," sizes="100vw" width="965" height="638"></p></div></div></div></div></div></div></div></div></div></div>

Thermo Scientific Dionex ICS-6000 HPIC System

The modular Thermo Scientific Dionex ICS-6000 HPIC system is a highly configurable ion chromatography (IC) system with high pressure capabilities.

<h3><strong>Dionex ICS-6000 HPIC System: Run different methods simultaneously</strong></h3><p><strong>The modular Thermo Scientific Dionex ICS-6000 HPIC system is a highly configurable ion chromatography (IC) system with high pressure capabilities. It enables you to develop and run different methods for a single sample or for different samples simultaneously. The robust design of this system enables operation at up to 5000 psi and produces consistent, reliable results. As a top-of-the-line ion chromatography system, the Dionex ICS-6000 HPIC system is designed to adapt to the needs of users and push the boundaries of what is possible in ion analysis.</strong></p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Dionex_ICS_6000_Iontovy_Chromatograf_3_cd832a923f/Thermo-Dionex-ICS-6000-Iontovy-Chromatograf-3.jpg" alt="Thermo Scientific Dionex ICS-6000 HPIC System." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Dionex_ICS_6000_Iontovy_Chromatograf_3_cd832a923f/thumbnail_Thermo-Dionex-ICS-6000-Iontovy-Chromatograf-3.jpg 156w," sizes="100vw" width="650" height="650"></figure><h3><strong>Highlights</strong></h3><h4><strong>Flexible configurations</strong></h4><p>Dionex ICS-6000 HPIC systems<strong> come in a variety of configurations</strong>, with the ability operate <strong>as a single- or dual-channel system</strong> to run samples concurrently. This high-pressure IC system can address a full range of IC applications, from <strong>2-D IC</strong> for trace-level analysis to<strong> high-performance anion-exchange chromatography with pulsed amperometric detection (HPAE-PAD) </strong>for complex carbohydrate analysis.</p><h4><strong>Wide range of IC columns</strong></h4><p>The Dionex ICS-6000 HPIC system is compatible with<strong> 4 μm-particle-size IC columns,</strong> which are available in <strong>150 or 250 mm lengths.</strong> The 150 mm-length columns decrease run times while maintaining chromatographic resolution. The 250 mm-length columns offer improved peak resolution.</p><h4><strong>Automated Eluent Generation (EG)</strong></h4><p>For unmatched method reproducibility and accuracy, the system can electrolytically generate <strong>high-purity hydroxide, carbonate, bicarbonate, or methanesulfonic acid (MSA) eluents </strong>when provided with a source of high-purity deionized water. Using the <strong>Dual EGC mode</strong>, the Dionex ICS-6000 HPIC system can <strong>also generate potassium hydroxide/potassium methanesulfonate (KOH/KMSA) eluents </strong>for complex carbohydrate analysis.</p><figure class="image"><img style="aspect-ratio:1246/940;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_ICS_6000_HPIC_System_66f622c7f9.jpg" alt="Thermo Scientific Dionex ICS-6000 HPIC System: Feutin alditol oligosaccharide analysis using (a) manually prepared eluents (NaOH/NaOAc) (b) Dual EGC mode (KOH/KMSA) with 1 mm column format (c) Dual EGC mode (KOH/KMSA) with 0.4 mm column format." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_ICS_6000_HPIC_System_66f622c7f9.jpg 206w," sizes="100vw" width="1246" height="940"></figure><h4><strong>Versatile detection capabilities</strong></h4><p>The system is<strong> </strong>compatible with a wide variety of detectors, including <strong>suppressed conductivity, electrochemical, UV-Vis absorbance, inductively coupled plasma mass spectrometry (ICP-MS), and mass spectrometry (MS).</strong></p><h4><strong>Mass spectrometry compatible</strong></h4><p>The Dionex ICS-6000 HPIC system is the<strong> ideal IC system to work in tandem with mass spectrometry, </strong>as it can used for a wide variety of sample analyses. From single quadrupole to high resolution accurate mass (HRAM) <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=5&amp;manufacturerItems=3&amp;search=Orbitrap"><strong>Thermo Scientific Orbitrap mass spectrometers</strong></a>, IC-MS analysis provides improved selectivity and higher sensitivity.</p><figure class="image"><img style="aspect-ratio:1245/682;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_ICS_6000_HPIC_System_3_ecfef0173d.jpg" alt="Thermo Scientific Dionex ICS-6000 HPIC System: HRAM MS/MS fragments facilitate identification of unknown compounds. IC, combined with HRAM mass spectrometry, is an ideal solution for component identification in non-targeted and unknown workflows. In this figure, identification of lithium-ion battery failure analysis products using HRAM MS/MS offers four-decimal-point accuracy to distinguish between species. The unique fragmentation signature enhances that confidence." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_ICS_6000_HPIC_System_3_ecfef0173d.jpg 245w," sizes="100vw" width="1245" height="682"></figure><figure class="image"><img style="aspect-ratio:1362/727;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_ICS_6000_HPIC_System_2_64749e2b9d.jpg" alt="Thermo Scientific Dionex ICS-6000 HPIC System: Targeted MS/MS analysis enables quantitation of molecules in a wide variety of matrices. IC, combined with triple quadrupole mass spectrometry, is an ideal solution for resolving molecules that are often difficult to separate from a matrix using conventional liquid chromatography techniques. In this chromatogram, glyphosate in drinking water is detected at a level of 5 ng/L. The linearity of the assay allows quantitation over 3 orders of magnitude, from 5 ng/L to 1000 ng/L, enabling a wide detection range without having to dilute samples." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_ICS_6000_HPIC_System_2_64749e2b9d.jpg 245w," sizes="100vw" width="1362" height="727"></figure><h4><strong>CDS Software</strong></h4><p>The Dionex ICS-6000 HPIC system comes with the<strong> easy-to-use Thermo Scientific Chromeleon Chromatography Data System (CDS)</strong>. This software provides powerful control and data processing for IC and offers eWorkflows that make all our essential applications easily accessible. Additionally,<strong> the Chromeleon CDS can control mass spectrometry systems, enabling seamless IC-MS analyses.</strong></p>

Thermo Scientific TSQ Quantis Plus Triple Quadrupole Mass Spectrometer

The Thermo Scientific TSQ Quantis Plus mass spectrometer provides effortless method set up with industry-leading multi-channel solutions and automated reporting.

<h3><strong>Advance quantitative workflows and increase productivity</strong></h3><p><strong>Address current and future challenges with Thermo Scientific TSQ Plus triple quadrupole mass spectrometers, which provide enhanced acquisition speed/sensitivity, proven robustness, and reliability. Instrument choices offer features for a range of applications, from everyday targeted quantitation to cutting-edge research.</strong></p><div colctrl-id="4-1"><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h2><strong>TSQ Quantis Plus Triple Quadrupole Mass Spectrometer</strong></h2><h3 data-uw-rm-heading="level" role="heading" aria-level="2"><strong>Extended quantitative performance made accessible</strong></h3><p>Experience reliability and sensitivity, and report results with confidence. The <strong>Thermo Scientific TSQ Quantis Plus mass spectrometer </strong>provides effortless method set up with <strong>industry-leading multi-channel solutions</strong> and <strong>automated reporting</strong> that enable robust high-throughput quantitation.</p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_1_0f234767cf/Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-1.jpg" alt="Thermo Scientific TSQ Quantis Plus Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_1_0f234767cf/thumbnail_Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-1.jpg 156w," sizes="100vw" width="650" height="650"></figure><div><h2><strong>Highlights</strong></h2></div><div colctrl-id="2-1"><div><div container-id="cq-colctrl-lt1" comp-id="A1"><div><p><strong>Advanced instrument control software, compound database integration,</strong> and <strong>predefined method templates</strong> simplify operations, enabling LC-MS/MS users of all skill sets to obtain high-confidence data.</p><p>Achieve next-level productivity, versatility, and performance for method development and routine sample analysis. The Thermo Scientific TSQ Quantis Plus triple quadrupole mass spectrometer combines <strong>enhanced acquisition speed</strong> and <strong>sensitivity with proven robustness and reliability </strong>to deliver confident targeted screening and quantitation for high-throughput applications.</p><div colctrl-id="3-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h3><strong>Reducing the barrier to productivity: Operational simplicity</strong></h3><p>Targeted research and routine applications demand fast and responsive instrument control software, with intuitive operations. <strong>Predefined method templates</strong> with<strong> integration to databases</strong>, including the <strong>Thermo Scientific mzCloud database</strong>, enable targeted quantitation method creation based on empirical knowledge. Also, direct method transfer from previous Thermo Scientific TSQ Quantis mass spectrometers can be loaded and operated <strong>without optimization</strong>.</p><p>Experimental determination of dwell times assigned to transitions is automated based on user-defined chromatographic peak width, with the option of fixed cycle time or optimal number of data points per chromatographic peak.&nbsp;Prioritization settings allow further adjustments.</p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_2_c265f9a0a3/Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-2.jpg" alt="Thermo Scientific TSQ Quantis Plus Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Quantis_Triple_Quadrupole_Mass_Spectrometer_2_c265f9a0a3/thumbnail_Thermo-TSQ-Quantis-Triple-Quadrupole-Mass-Spectrometer-2.jpg 156w," sizes="100vw" width="650" height="650"></figure></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h3><strong>Speed with selectivity and sensitivity</strong></h3><p>Achieve superior acquisition speeds on the TSQ Quantis Plus mass spectrometer, which can acquire <strong>600 SRMs/sec</strong> and when combined with a new power supply enables <strong>5 ms polarity switching</strong> and allows the required number of data points to be acquired for expanded number of target compounds, even with ultra-high performance liquid chromatography (UHPLC) separation.</p><p>The TSQ Quantis Plus mass spectrometer delivers excellent quantitative performance in both selected reaction monitoring (SRM) and high-resolution selected reaction monitoring (H-SRM) for fit-for-purpose selectivity. The enhanced active<strong> Q2 collision cell </strong>improves product ion transmission, especially for low-mass product ions, which can increase detection efficiency.</p></div></div></div></div><div colctrl-id="4-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h3><strong>Expanded experimental capabilities</strong></h3><p>Integrated workflow solutions centered on the TSQ Quantis Plus mass spectrometer address regulated requirements targeting a growing list of diverse compounds. New UHPLC and high performance ion chromotagraphy (HPIC) systems maximize sample delivery and separation capabilities, maintaining the sensitivity to meet minimum residue limits without costly sample preparation or derivatization steps. Thermo Scientific<strong> Chromeleon Chromatography Data System</strong> (CDS) controls all experimental attributes in a regulated environment to further drive productivity.</p></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h3><strong>Robust and reliable quantitation</strong></h3><p>Innovative designs in the ion source, neutral blocker, and mass analyzers maintain optimal performance while maximizing instrument uptime. The ion transfer tube enables simple extraction and cleaning in minutes, without breaking the instrument vacuum or requiring instrument calibration. New integrated instrument performance check and calibration routine reduce manual interaction, maximizing data acquisition and instrument productivity.</p></div></div></div></div></div></div></div></div></div></div></div></div>

Thermo Scientific TSQ Fortis Plus Triple Quadrupole Mass Spectrometer

The TSQ Fortis Plus provides a seamless user experience for clinical research laboratories that focus on processing and analyzing a large number of samples.

<p class="cke-user_style-important"><strong>Advance quantitative workflows and increase productivity</strong></p><p><strong>Address current and future challenges with Thermo Scientific TSQ Plus triple quadrupole mass spectrometers, which provide enhanced acquisition speed/sensitivity, proven robustness, and reliability. Instrument choices offer features for a range of applications, from everyday targeted quantitation to cutting-edge research.</strong></p><h2><strong>TSQ Fortis Plus Triple Quadrupole Mass Spectrometer</strong></h2><h3 data-uw-rm-heading="level" role="heading" aria-level="2"><strong>Robust quantitative performance made simple</strong></h3><p>The <strong>TSQ Fortis Plus</strong> provides a seamless user experience for <strong>clinical research laboratories</strong> that focus on processing and analyzing a <strong>large number of samples</strong>. Designed for ease, it enables confident quantitation of hundreds of <strong>samples in complex matrices</strong>, every day.</p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Fortis_Plus_Triple_Quadrupole_Mass_Spectrometer_1_5021103aa3/Thermo-TSQ-Fortis-Plus-Triple-Quadrupole-Mass-Spectrometer-1.jpg" alt="Thermo Scientific TSQ Fortis Plus Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Fortis_Plus_Triple_Quadrupole_Mass_Spectrometer_1_5021103aa3/thumbnail_Thermo-TSQ-Fortis-Plus-Triple-Quadrupole-Mass-Spectrometer-1.jpg 156w," sizes="100vw" width="650" height="650"></figure><div><h2 id="menu1"><strong>Highlights</strong></h2></div><div colctrl-id="2-1"><div><div container-id="cq-colctrl-lt1" comp-id="A1"><div><p>Accelerate your path to quantitative productivity with the <strong>Thermo Scientific TSQ Fortis Plus triple quadrupole mass spectrometer</strong>. Enhanced acquisition speed and sensitivity, combined with proven robustness and reliability, deliver next-level performance and value for <strong>high-throughput analyses</strong>. Simplified operations integrated with powerful Thermo Scientific chromatographic systems and market-leading software ensure users of all skill levels obtain reproducible, high-confidence results that meet laboratory requirements.</p><div colctrl-id="3-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h3><strong>Reducing the barrier to productivity: Operational simplicity</strong></h3><p>Targeted research and routine applications demand fast and responsive instrument control software, with intuitive operations. <strong>Predefined method templates</strong> with integration to databases, including the <strong>Thermo Scientific mzCloud database</strong>, enable targeted quantitation method creation based on empirical knowledge. Also, <strong>direct method transfer from previous TSQ Fortis mass spectrometers </strong>can be loaded and operated without optimization.</p><p>Experimental determination of dwell times assigned to transitions is automated based on user-defined chromatographic peak width, with the option of fixed cycle time or optimal number of data points per chromatographic peak. Prioritization settings allow further adjustments.&nbsp;</p></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h3><strong>Speed with selectivity and sensitivity</strong></h3><p>Achieve superior acquisition speeds on the <strong>TSQ Fortis Plus mass spectrometer</strong>, which can acquire <strong>600 SRMs/sec</strong> and when combined with a new power supply enables <strong>5 ms </strong>polarity switching and allows the required number of data points to be acquired for expanded number of target compounds, even with ultra-high performance liquid chromatography (UHPLC) separation.</p><p>The TSQ&nbsp;Fortis Plus mass spectrometer delivers excellent quantitative performance in both selected reaction monitoring (SRM) and high-resolution selected reaction monitoring (H-SRM) for fit-for-purpose selectivity. The enhanced active <strong>Q2 collision cell </strong>improves product ion transmission, especially for low-mass product ions, which can increase detection efficiency.</p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Fortis_Plus_Triple_Quadrupole_Mass_Spectrometer_3_a876fda658/Thermo-TSQ-Fortis-Plus-Triple-Quadrupole-Mass-Spectrometer-3.jpg" alt="Thermo Scientific TSQ Fortis Plus Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Fortis_Plus_Triple_Quadrupole_Mass_Spectrometer_3_a876fda658/thumbnail_Thermo-TSQ-Fortis-Plus-Triple-Quadrupole-Mass-Spectrometer-3.jpg 156w," sizes="100vw" width="650" height="650"></figure></div></div></div></div><div colctrl-id="4-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h3><strong>Expanded experimental capabilities</strong></h3><p>Integrated workflow solutions centered on the <strong>TSQ Fortis Plus mass spectrometer</strong> address regulated requirements targeting a growing list of diverse compounds. New UHPLC and high performance ion chromotagraphy (HPIC) systems maximize sample delivery and separation capabilities, maintaining the sensitivity to meet minimum residue limits without costly sample preparation or derivatization steps. The <strong>Thermo Scientific Chromeleon Chromatography Data System</strong> (CDS) controls all experimental attributes in a regulated environment to further drive productivity.</p></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h3><strong>Robust and reliable quantitation</strong></h3><p><strong>Innovative designs in the ion source, neutral blocker</strong>, and<strong> mass analyzers</strong> maintain optimal performance while maximizing instrument uptime. The ion transfer tube enables simple extraction and cleaning in minutes, without breaking the instrument vacuum or requiring instrument calibration. New integrated instrument performance checks and calibration routine reduce manual interaction, maximizing data acquisition and instrument productivity.</p></div></div></div></div></div></div></div></div>

Products from Thermo Fisher Scientific - page 17

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