As regulations evolve and PFAS analysis expands beyond traditional water testing, laboratories are adapting to new challenges across environmental, food and industrial sectors.Laboratories around the world are facing a new reality for <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/environmental/environmental-contaminant-analysis/emerging-contaminants/pfas-testing.html">PFAS analysis</a>. Expanding regulations, growing lists of compounds of concern, and increasing demand for analysis across environmental, food and industrial sectors mean many laboratories are being asked to do more than ever before.While these changes are global, Europe continues to play an important role in shaping the regulatory landscape. Since January 2026, EU Member States have been required to monitor PFAS levels in drinking water and ensure they remain within EU limits. Regulatory attention is also extending beyond drinking water to surface and groundwater, soil, packaging and industrial emissions, as outlined in the <a target="_blank" rel="noopener noreferrer" href="https://environment.ec.europa.eu/topics/chemicals/pfas-pollution_en">European Commission’s overview of PFAS pollution and EU action</a>.Although requirements differ by region, the direction is clear: laboratories are facing analytical questions involving more compounds and a wider range of matrices. For scientists looking to keep pace, our <a target="_blank" rel="noopener noreferrer" href="https://gateway.on24.com/wcc/eh/4080611/category/139628/pfas-testing?partnerref=E.25CMD.EL102.26305.01">PFAS resources</a> bring together webinars, application notes and expert insights across environmental, food and industrial testing.<h5>PFAS analysis is no longer defined by a single matrix or a single workflow.</h5><h3>PFAS analysis is expanding</h3>For many laboratories, PFAS analysis began with drinking water. Today, the scope has expanded considerably.Laboratories are increasingly working across drinking water, groundwater, surface water and wastewater, as well as food and food contact materials, cosmetics and personal care products, environmental samples, and industrial and consumer products.Each matrix presents different analytical challenges. Water analysis can require trace-level quantification, while complex food and consumer-product matrices may require different sample preparation or broader screening approaches. Techniques such as total organic fluorine (TOF) analysis can also provide a complementary perspective to targeted PFAS measurements.This diversity means there is no single analytical approach that answers every PFAS question.<h5>As PFAS analysis expands beyond drinking water, laboratories need approaches that can adapt to diverse sample types and evolving regulatory expectations.</h5><h3>Learning from the scientific community</h3>As laboratories respond to these changing analytical demands, many are exploring new approaches to longstanding challenges such as sample preparation.One example comes from Severn Trent Laboratories (Bridgend, UK), which implemented a PFAS workflow using Dispersive Liquid–Liquid Micro Extraction (DLLME). The approach provides an alternative to traditional solid phase extraction and can help reduce sample handling and solvent consumption.Laboratories interested in the approach can explore more information on <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/environmental/efox-analytical-solutions-platform/workflows.html">DLLME and PFAS workflows</a>.<h3>Watch the webinar</h3><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_Water_Meeting_the_Challenges_of_Environmental_Food_and_Industrial_Testing_2aeaa52248.jpg" alt="Thermo Fisher Scientific: PFAS Analysis Beyond Water: Meeting the Challenges of Environmental, Food and Industrial Testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_Water_Meeting_the_Challenges_of_Environmental_Food_and_Industrial_Testing_2aeaa52248.jpg 245w," sizes="100vw" width="800" height="347"><h4>Severn Trent / PFAS webinar</h4>EFOX approach for environmental workflows: PFAS &amp; emerging contaminantsHear more about this approach and explore wider developments in PFAS and emerging contaminant analysis.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/webinar/6542">Watch on demand</a></h4></blockquote><h3>The changing PFAS landscape</h3>The changing analytical landscape extends well beyond sample preparation. Laboratories are simultaneously navigating evolving regulations, growing lists of compounds of interest, greater scrutiny of food and industrial materials, and increasing interest in broader screening approaches.Europe illustrates how these trends are converging. Alongside drinking-water requirements, EU action extends to industrial emissions and food-contact packaging. The Industrial Emissions Directive imposes stricter monitoring of PFAS emissions, with reporting requirements for PFOA, PFHxS and their salts from 2028. From August 2026, EU rules also ban food-contact packaging containing PFAS above specified concentration limits, as detailed in the <a target="_blank" rel="noopener noreferrer" href="https://environment.ec.europa.eu/topics/chemicals/pfas-pollution_en">European Commission’s overview of PFAS pollution and EU action</a>.Changes are also underway for Europe’s surface water and groundwater. Updated pollutant lists that entered into force in May 2026 include certain PFAS, including TFA, among substances to be monitored more closely and subject to stricter controls under the <a target="_blank" rel="noopener noreferrer" href="https://environment.ec.europa.eu/topics/water/water-framework-directive_en">EU Water Framework Directive.</a>The European picture also demonstrates why PFAS is no longer solely an environmental-water issue. PFAS have been widely used in products including food packaging, textiles, lubricants and batteries, while industrial activities that produce or use PFAS can contribute to environmental releases.Globally, regulatory requirements vary, but the analytical challenge is similar: laboratories need the flexibility to respond as both the compounds of interest and the matrices under investigation change.<h3>PFAS analysis across different sample types</h3>Different matrices raise different analytical questions—from selecting an appropriate sample preparation strategy to deciding between targeted quantification and broader screening approaches.<h4>Environmental and water PFAS analysis</h4><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_Water_Meeting_the_Challenges_of_Environmental_Food_and_Industrial_Testing_2_3ef68ae44e.jpg" alt="Thermo Fisher Scientific: PFAS Analysis Beyond Water: Meeting the Challenges of Environmental, Food and Industrial Testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_Water_Meeting_the_Challenges_of_Environmental_Food_and_Industrial_Testing_2_3ef68ae44e.jpg 245w," sizes="100vw" width="768" height="439">Explore analytical approaches for drinking water, groundwater, surface water and wastewater, including automated sample preparation and multi-matrix PFAS quantification.<ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/content/lifetech/global/en/home/industrial/environmental/efox-analytical-solutions-platform/workflows.html">Automated DLLME for environmental PFAS analysis</a></li><li>Resource: <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/ab_004180_efs_orbitrap_exploris_efox_ab004180_em_en_932cc99eb4.pdf">Quantification of 61 PFAS across drinking water, groundwater, surface water and wastewater</a></li></ul><h4>Food and food contact materials PFAS analysis</h4><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_Water_Meeting_the_Challenges_of_Environmental_Food_and_Industrial_Testing_3_eb783dd0d3.jpg" alt="Thermo Fisher Scientific: PFAS Analysis Beyond Water: Meeting the Challenges of Environmental, Food and Industrial Testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_Water_Meeting_the_Challenges_of_Environmental_Food_and_Industrial_Testing_3_eb783dd0d3.jpg 245w," sizes="100vw" width="768" height="433">Explore PFAS analysis in food and food-contact materials, including total organic fluorine (TOF) screening and evolving approaches to investigating fluorinated compounds in packaging.<ul><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/5894">Enhancing PFAS analysis in food contact materials using combustion ion chromatography</a></li></ul><h4>Cosmetics / industrial PFAS analysis</h4><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_Water_Meeting_the_Challenges_of_Environmental_Food_and_Industrial_Testing_4_99a5bfea7e.jpg" alt="Thermo Fisher Scientific: PFAS Analysis Beyond Water: Meeting the Challenges of Environmental, Food and Industrial Testing" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_Water_Meeting_the_Challenges_of_Environmental_Food_and_Industrial_Testing_4_99a5bfea7e.jpg 245w," sizes="100vw" width="768" height="432">Explore approaches for investigating PFAS and total organic fluorine in complex matrices such as cosmetics and other consumer or industrial materials.<ul><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_004403_ic_cic_industrial_an004403_na_en_3c2419b88b.pdf">Total PFAS content in cosmetics using combustion ion chromatography</a></li></ul><blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gateway.on24.com/wcc/eh/4080611/category/139628/pfas-testing?partnerref=E.25CMD.EL102.26305.01">Explore all PFAS resources</a></h4></blockquote><h3>Learn from experts</h3>As PFAS science and regulation continue to evolve, knowledge sharing across the scientific community is becoming increasingly valuable.<h4>Live from the Lab: Solutions for Environmental and Food Contaminant Analysis 2026</h4><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_Water_Meeting_the_Challenges_of_Environmental_Food_and_Industrial_Testing_5_3afde1ec49.jpg" alt="Thermo Fisher Scientific - PFAS Analysis Beyond Water - Meeting the Challenges of Environmental, Food and Industrial Testing 5.jpg" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_PFAS_Analysis_Beyond_Water_Meeting_the_Challenges_of_Environmental_Food_and_Industrial_Testing_5_3afde1ec49.jpg 245w," sizes="100vw" width="768" height="402">Join scientists from industry and academia to explore developments in environmental and food contaminant analysis. PFAS-focused discussions include regulatory trends, drinking water analysis, food-contact materials, workflow optimisation, source differentiation, and untargeted screening. Register to join us online or in person at one of our satellite events across Europe.<blockquote><h4><a target="_blank" rel="noopener noreferrer" href="https://gateway.on24.com/wcc/eh/4080611/category/150288/lftl-event-environmental-and-food-contaminant-testing?partnerref=E.25CMD.EL102.26305.01">Register here: Live from the Lab: Solutions for Environmental and Food Contaminant Testing</a></h4></blockquote><h3>Looking ahead</h3>PFAS analysis is unlikely to become simpler. As regulations evolve and new areas of testing emerge, laboratories will continue to face broader analytical questions across environmental, food and industrial testing.Preparing for the future isn’t about predicting every regulatory change. It’s about developing the knowledge and flexibility to respond as new compounds, matrices and analytical questions emerge.How is your laboratory preparing for the next phase of PFAS analysis? Whether you’re responding to new regulations, expanding into different matrices or evaluating new analytical approaches, staying connected to developments across the scientific community can help you prepare for what’s next.<blockquote>Visit us on&nbsp;<a target="_blank" rel="noopener noreferrer" href="https://www.linkedin.com/showcase/72003132/admin/dashboard/">LinkedIn:</a>&nbsp;#PFAS #PFASAnalysis #EnvironmentalTesting #FoodSafety</blockquote>

PFAS Analysis Beyond Water: Meeting the Challenges of Environmental, Food and Industrial Testing

<h3>Beyond Exact Matches: Manual and Automated Hybrid Searches in NIST26</h3>Conventional MS/MS library searching works best when the spectrum of an unknown compound closely matches a reference spectrum already stored in the library. But real samples frequently contain compounds that are absent from available libraries. In his presentation <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/Manual_and_Automated_Hybrid_searches_44b28ae6a0.pdf">Manual and Automated Hybrid Searches in NIST26</a>, James Little of Mass Spec Interpretation Services demonstrates how the hybrid-search capabilities in NIST26 can extend effective library coverage by finding structurally related compounds and using their spectral relationships to guide the identification of unknowns.<h4>Extending MS/MS library searching beyond exact matches</h4>A conventional library search attempts to find spectra that closely resemble the measured spectrum. This approach can provide highly confident identifications when an appropriate reference spectrum is available, but its usefulness decreases when the unknown compound itself is missing from the library.The Hybrid MS/MS Search in the NIST Mass Spectral Search Program takes a different approach. Rather than requiring an exact spectral match, it can recognize spectra of structurally related compounds and account for systematic mass differences between the unknown and library candidates. This makes it possible to use existing reference spectra to investigate compounds that have not themselves been measured and deposited in the library.In NIST26, hybrid searching can be performed in two ways:<ul><li>manually by sending individual spectra to the Library Search window,</li><li>automatically as part of the Chromatogram workflow.</li></ul>The two approaches complement one another: automated searching can rapidly screen many chromatographic components, while manual searching provides more opportunities to examine individual candidates and investigate their structures in greater detail.<h4>Using mass differences to recognize structural relationships</h4>An important element of the hybrid search is the interpretation of the mass difference between an unknown spectrum and a related library spectrum.NIST26 reports this difference together with Δform (dForm), which represents a plausible elemental composition associated with the observed mass shift. Instead of treating a different precursor mass as evidence that two compounds are unrelated, the software can therefore evaluate whether the difference corresponds to a chemically reasonable structural modification.The presentation also highlights pctRefForm, a statistical measure related to how frequently a particular dForm occurs relative to commonly observed modifications. Higher values indicate more frequently observed and therefore generally more plausible formula differences, whereas extremely rare differences may be accidental and should be interpreted cautiously.This additional information helps transform a library hit from a simple similarity result into a starting point for structural interpretation.<h4>A manual workflow for investigating unknown chromatographic components</h4>James Little demonstrates a practical workflow in which a standard chromatogram search is first performed and components without a confident identification are selected for further investigation.The unidentified components can be sorted by relative abundance, allowing the analyst to prioritize the most significant signals. Individual spectra are then reviewed, including through butterfly plots, and promising components can be manually transferred to the Library Search window for a hybrid search.This approach is particularly useful when an automated conventional search has failed to provide a satisfactory identification but the spectrum still contains enough structural information to point toward a related compound class.<h4>Identifying a PEG-related unknown</h4>The presentation illustrates the process using an unknown associated with polyethylene glycol (PEG)-type materials. The spectrum suggested an ammonium adduct, (M+NH₄)⁺, followed by the loss of ammonia.Hybrid searching produced candidates related to PEG ethers, with the most reasonable interpretation being a dodecyl ether of polyethylene glycol. The proposed library candidate was then examined in the NIST MS Interpreter to understand its fragmentation behavior.A particularly informative result came from the observed mass difference. The dForm indicated a loss corresponding to three ethylene glycol repeat units, with an observed value of 132.079 matching the theoretical value of 132.079. This agreement provided additional evidence that the unknown and the library candidate belonged to the same structural family but differed in PEG chain length.The candidate structure could then be modified by removing three ethylene glycol repeat units and transferred back to the MS Interpreter for further evaluation. The example shows how a hybrid search can move the analyst beyond simply asking “What compound is in the library?” toward the more useful question “How might my unknown differ from the closest known structure?”<h4>Why ammonium adducts require special attention</h4>Adduct chemistry can complicate MS/MS library searching. In the example presented, the experimental precursor was observed as (M+NH₄)⁺, whereas the NIST MS/MS Library contains more spectra acquired from (M+H)⁺ precursors.The presentation notes that NIST does not intentionally add ammonium when acquiring reference spectra. When an analyst observes a loss of 17 Da, corresponding to NH₃, it can therefore be useful to recognize that the underlying fragmentation may effectively correspond to the protonated molecule.For such cases, Little recommends replacing the precursor value used for searching with the corresponding (M+H)⁺ value rather than relying solely on the precursor displayed in the experimental spectrum.In the PEG example, doing so still returned two monodecyl ether candidates as the leading hits. Importantly, the presentation notes that the major MS/MS fragments generated from the ammonium and protonated precursor forms were essentially the same, supporting comparison with the protonated reference spectra.<h4>Automating hybrid searches across a chromatogram</h4>Manual inspection is valuable when investigating a small number of important unknowns, but chromatographic datasets may contain hundreds of components. NIST26 therefore also supports automated hybrid searching within the Chromatogram workflow.The analyst selects the input file, enables Hybrid Search, and can choose to run the process in the background. Because hybrid searching performs substantially more processing than a standard search, the presentation notes that it can require significantly more time. NIST26 displays the background-task status and alerts the user when processing is complete.The resulting components can again be filtered to focus on unidentified compounds and sorted according to abundance. In the example shown, the automated search returned the same PEG-related candidate found during the manual investigation, demonstrating consistency between the two approaches.Automated hybrid searching can therefore act as an efficient first-pass screening tool, while selected results can subsequently be transferred to the Library Search window for closer examination of candidate structures and fragmentation.<h4>From library matching to structural investigation</h4>Hybrid searching does not eliminate the need for expert interpretation. Instead, it expands the information available when an exact reference spectrum is missing.By combining spectral similarity with precursor-mass differences, plausible dForm values, fragmentation interpretation, and structural modification, NIST26 provides a workflow for moving from an unidentified chromatographic feature toward a chemically meaningful candidate.The presentation demonstrates that the strongest workflow is often a combination of automation and manual interpretation: automated searching identifies promising relationships across large datasets, while targeted manual analysis helps determine whether those relationships make chemical sense. In this way, hybrid searching extends the practical value of spectral libraries beyond the compounds they contain directly and makes them more useful for the investigation of previously uncharacterized analytes.

Manual and Automated Hybrid Searches in NIST26

ISC 2026 - Day 5

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The International Symposium on Chromatography (ISC) represents the oldest conference series focussing on separation science. ISC symposia have been organised since 1956 in each even year. ISC is internationally recognised as one of the premier meeting series for discussion of all modes of chromatography and separation science with a broad coverage of techniques and applications.

International Symposium on Chromatography - (ISC)

My main interest is the identification of organic compounds by mass spectrometry in organic mixtures.

James Little/Mass Spec Interpretation Services

Thermo Scientific Accucore Polar Premium HPLC Columns

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Achieve fast, high-resolution separations of polar and nonpolar analytes using Thermo Scientific™ Accucore™ Polar Premium LC columns. Rugged 2.6μm solid-core particles enable fast, high-efficiency separations at low backpressures.&nbsp;The robust amide-embedded C18 stationary phase provides unique selectivity complementary to conventional C18 columns, is stable from pH 1.5–10, and is fully compatible with highly aqueous mobile phases. Robust bonding technology and automated packing procedures ensure excellent reproducibility and long column lifetimes.<h5>Alternative Selectivity</h5><ul><li>Polar embedded reverse phase material offers complementary selectivity to standard C18 columns.</li></ul><h5>Stable over Wide pH Range</h5><ul><li>Specially designed bonded phase is stable from pH 1.5–10.5.</li></ul><h5>Compatible with Highly Aqueous Mobile Phases</h5><ul><li>Rugged amide-embedded C18 phase will not undergo phase collapse in 100% aqueous mobile phase.</li></ul><h5>Fast Separations</h5><ul><li>2.6μm core-enhanced technology particles enable operation at high flow rates without generating excessive backpressures.</li></ul><h5>Excellent Peak Shapes for Enhanced Resolution and Sensitivity</h5><ul><li>Solid-core 2.6μm particles and narrow particle size distribution reduce band broadening and improve separation efficiencies.</li><li>High surface coverage of silica minimizes secondary interactions and peak tailing.</li></ul><h5>Low Backpressures</h5><ul><li>Solid-core 2.6μm particles for less backpressure compared to UHPLC sub-2μm particles</li><li>Compatible with conventional HPLC instrumentation and UHPLC platforms</li></ul><h5>Excellent Reproducibility and Robustness</h5><ul><li>Advanced bonding technology</li><li>Automated packing process</li></ul><h4>Specifications</h4><ul><li>Endcapped: Yes</li><li>Max. Pressure: 14500 psi (1000 bar)</li><li>Packing Material: Spherical, Solid Core, Ultrapure Silica</li><li>Particle Shape: Spherical Solid Core</li><li>Stationary Phase: Polar Embedded</li><li>Surface Area: 90 m²/g</li><li>Temperature: 70°C</li><li>USP Type: L60</li><li>Carbon Load: 9%</li><li>Phase: Reversed Phase</li><li>Pore Size: 150 Å</li><li>pH: 1.5 to 10.5</li></ul>

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Offer unique selectivity for aromatic and moderately polar analytes with Thermo Scientific™ Accucore™ Phenyl-Hexyl LC Columns.Based on Core Enhanced Technology, Accucore columns provide fast, high-resolution separations without the elevated backpressures required by sub-2μm particles.<ul><li>Fast separations with excellent resolution and sensitivity</li><li>Lower backpressures so that UHPLC is not required</li><li>Mixed-Mode Selectivity for Aromatic and Moderately Polar Analytes</li><li>Enhanced Pi-pi Interactions with Aromatics</li><li>Moderate Hydrophobicity</li></ul><h4>Specifications</h4><ul><li>Endcapped: Yes</li><li>For Use With: HPLC</li><li>Max. Pressure: 14500 psi (1000 bar)</li><li>Packing Material: Spherical, Solid Core, Ultrapure Silica</li><li>Particle Shape: Spherical Solid Core</li><li>Stationary Phase: Phenyl/Hexyl</li><li>Surface Area: 130 m²/g</li><li>Temperature: 70°C</li><li>USP Type: L11</li><li>Carbon Load: 5%</li><li>Phase: Reversed Phase</li><li>Pore Size: 80 Å</li><li>pH: 2 to 8</li></ul>

Thermo Scientific Q Exactive Plus Hybrid Quadrupole-Orbitrap Mass Spectrometer

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Take Quanfirmation™ to the next level. The Thermo Scientific™ Q Exactive™ Hybrid Quadrupole-Orbitrap™ Mass Spectrometer introduced the revolutionary concept of Quanfirmation. The Q Exactive™ Plus Hybrid Quadrupole-Orbitrap™ Mass Spectrometer takes Quanfirmation to the next level with increased performance and new options that enhance applications from confident DMPK qual/quan screening studies to characterization of intact monoclonal antibodies.<h5>Superior Quantitation</h5><ul><li>Advanced quadrupole technology (AQT) improves precursor selection and transmission for more-accurate quantitation of low-abundance analytes in complex matrices</li><li>Sophisticated data-independent acquisition (DIA) and parallel reaction monitoring (PRM) deliver reproducible quantitation with complete qualitative confidence</li><li>An advanced active beam guide (AABG) reduces noise and extends maintenance intervals</li></ul><h5>Enhanced Analysis of Intact Proteins</h5><ul><li>Optional intact protein mode provides superior trapping of large molecules for improved analysis of intact proteins and protein complexes</li><li>Optional enhanced resolution ensures maximum ID confidence in top-down proteomics and lipidomics</li></ul><h5>High-Confidence Results</h5><ul><li>HR/AM and full-scan capabilities capture all sample data, all of the time, enabling retrospective data analysis without need to re-run samples</li><li>Resolving power up to 140,000 FWHM eliminates isobaric interferences, increasing confidence in results when analyzing samples in complex matrices</li><li>Better than 1-ppm mass accuracy in full- and all-ion fragmentation (AIF) scan modes ensures confident compound identification</li><li>Fast scanning at 12 Hz and spectral multiplexing suited to UHPLC applications</li><li>Rapid polarity switching maximizes information obtained</li><li>AIF and multiple dissociation techniques — in-source CID and HCD — aid in compound identification</li><li>Mass range to 6000 m/z enhances detection of singly charged small molecules and biomolecules</li><li>More than four orders of magnitude intrascan dynamic range, along with femtogram-level sensitivity, allow detection of trace-level and high-abundance compounds in the same scan</li></ul>

Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole Orbitrap™ Mass Spectrometer

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<h3>Go beyond what you thought possible with native mass spectrometry</h3>The Thermo Scientific™ Q Exactive™ UHMR is the first hybrid quadrupole-Orbitrap™ mass spectrometer designed specifically for ultra-high mass range (UHMR) native MS and top-down protein analysis. It combines exceptional sensitivity, ultra-high resolution at high m/z, and unique pseudo-MS³ capabilities, enabling detailed characterization of intact protein assemblies and complex biological systems.<h3>🔬 Breakthrough in Native Mass Spectrometry</h3>Native mass spectrometry preserves the non-covalent structure and interactions of proteins and protein complexes, making it an indispensable tool for structural biology and biopharma. The Q Exactive UHMR system enables direct mass analysis of intact macromolecules, including membrane proteins, virus capsids, and ribosomal particles—with unrivaled detail.<ul><li>Ultra-high mass range detection up to 80,000 m/z</li><li>Native top-down analysis of protein complexes and assemblies</li><li>High sensitivity for precious or low-abundance samples</li><li>Resolve mass differences even in heterogeneous megaDalton assemblies</li></ul><h3>⚙️ Technological Innovations</h3>The Q Exactive UHMR system integrates multiple hardware advancements to overcome the historical limitations of native MS:<ul><li>In-source trapping for efficient desolvation and controlled dissociation</li><li>Advanced quadrupole mass filter with selection up to 25,000 m/z</li><li>Reduced RF frequencies across the ion path for better high-mass transmission</li><li>Pseudo-MS³ capability: fragment large complexes into subunits, then sequence them in HCD cell</li></ul><h3>🧬 Applications and Capabilities</h3><h4>Confident characterization of complex biological systems:</h4><ul><li>Virus capsid analysis: Differentiation and sequencing of 3–4 MDa hepatitis B virus capsids</li><li>Ribosome studies: Resolution of substoichiometric proteins in E. coli 70S particles</li><li>Membrane proteins: Gentle liberation from micelles and native top-down sequencing (e.g., AmtB trimer)</li><li>Chaperonin complexes: Native top-down analysis of GroEL tetradecamer</li></ul><h4>Detect and resolve small differences in high-mass species:</h4><ul><li>Post-translational modifications</li><li>Ligand binding</li><li>Protein truncations and isoforms</li></ul><h3>💡 Software for Confident Data Interpretation</h3>Maximize the power of native MS with industry-leading software:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1837">BioPharma Finder™ Software </a>– For intact mass confirmation, top-down analysis, and PTM localization</li><li>ProSightPC™ Software – Advanced top-down proteomics with integrated UniProt database search</li></ul><h3>🧪 Who Is It For?</h3>Ideal for research groups and industry labs focused on:<ul><li>Structural biology</li><li>Biotherapeutic development</li><li>Native and top-down proteomics</li><li>Protein-ligand interaction studies</li></ul><h3>🧭 Summary of Key Features</h3><ul><li>Mass range: Up to 80,000 m/z</li><li>Quadrupole isolation: Up to 25,000 m/z</li><li>Sensitivity: Orders of magnitude higher at high m/z</li><li>Fragmentation: HCD, pseudo-MS3 for native top-down</li><li>In-source trapping: Yes, optimized for membrane protein assemblies</li><li>Software: BioPharma Finder, ProSightPC</li><li>Compatible analyses: Native MS, top-down, intact mass, charge detection</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Q_Exactive_UHMR_Hybrid_Quadrupole_Orbitrap_hmotnostni_spektrometr_a7f594a56d/Pragolab-Thermo-Q-Exactive-UHMR-Hybrid-Quadrupole-Orbitrap-hmotnostni-spektrometr.webp" alt="Thermo Scientific™ Q Exactive™ UHMR Hybrid Quadrupole Orbitrap™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Q_Exactive_UHMR_Hybrid_Quadrupole_Orbitrap_hmotnostni_spektrometr_a7f594a56d/thumbnail_Pragolab-Thermo-Q-Exactive-UHMR-Hybrid-Quadrupole-Orbitrap-hmotnostni-spektrometr.webp 156w," sizes="100vw" width="650" height="650">

Thermo Scientific™ Orbitrap™ IQ-X™ Tribrid™ Mass Spectrometer

Know your unknown compounds with confidence, using intelligent mass spectrometry that combines ease-of-use with smart acquisition methods to deliver higher data certainty.

Designed to unravel complex chemical structures while delivering the highest versatility and comprehensive workflow support for unknown compound ID and small molecule analysis, the Thermo Scientific™ Orbitrap™ IQ-X™ Tribrid™ mass spectrometer empowers you to collect more meaningful data.Combining industry-leading mass analyzer technology analysis with intelligent acquisition, intuitive software and remote, hands free calibration, discover a new level of improved confidence in structure elucidation, with on-the-fly identification of small molecules to reveal more chemical structures with ease.The Orbitrap IQ-X Tribrid MS seamlessly integrates with industry-leading solutions to provide a complete workflow solution, including Thermo Scientific™ Vanquish™ Duo UHPLC Systems, Thermo Scientific™ FAIMS Pro Duo interface for differential ion mobility, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1759">Thermo Scientific™ Compound Discoverer™ data analysis software</a>, and the most comprehensive spectral libraries available on <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1764">Thermo Scientific™ mzCloud™</a>, enabling an intelligent MSⁿ data acquisition strategy to easily conduct small molecule structural elucidation, identification, and characterization.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Orbitrap_IQ_X_Tribrid_hmotnostni_spektrometr_1_a565298840/Pragolab-Thermo-Orbitrap-IQ-X-Tribrid-hmotnostni-spektrometr-1.webp" alt="Thermo Scientific™ Orbitrap™ IQ-X™ Tribrid™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Orbitrap_IQ_X_Tribrid_hmotnostni_spektrometr_1_a565298840/thumbnail_Pragolab-Thermo-Orbitrap-IQ-X-Tribrid-hmotnostni-spektrometr-1.webp 238w," sizes="100vw" width="1447" height="949"><h5>Other benefits of this mass spectrometry system include:</h5><ul><li>A combination of the best of quadrupole, linear ion trap and Thermo Scientific™ Orbitrap™ mass analyzer technology for acquisition of the richest MSⁿ data per sample.</li><li>Spend more time on results, less time on instrument set-up with the new Auto-Ready ion source for remote, hands free calibration, combined with the Thermo Scientific™ EASY-IC™ (Internal Calibration) source to deliver superior mass accuracy in every scan, mass calibration can be fully automated, increasing productivity.</li><li>Real-Time Library Search provides higher confidence small molecule analysis using on-the-fly spectral matching for decision-based triggering of MSⁿ scan events that increase certainty.</li><li>Expanded <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1763">Thermo Scientific™ AcquireX workflow</a> capabilities provide easy and intelligent acquisitions to find more compounds by integrating independent experiments into an automated workflow for efficient and comprehensive sample and study characterization.</li><li>Flexible fragmentation choices for structural determination of lipids, metabolites, and other small molecules utilizing Collision induced dissociation (CID), Higher-energy collisional dissociation (HCD) and optional Ultraviolet Photodissociation (UVPD).</li><li>Improved unknown analysis and fine isotope detection with optional 1,000,000 (1M) FWHM resolution at m/z 200.</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Orbitrap_IQ_X_Tribrid_hmotnostni_spektrometr_2_3b50aefc74/Pragolab-Thermo-Orbitrap-IQ-X-Tribrid-hmotnostni-spektrometr-2.webp" alt="Thermo Scientific™ Orbitrap™ IQ-X™ Tribrid™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Orbitrap_IQ_X_Tribrid_hmotnostni_spektrometr_2_3b50aefc74/thumbnail_Pragolab-Thermo-Orbitrap-IQ-X-Tribrid-hmotnostni-spektrometr-2.webp 245w," sizes="100vw" width="1880" height="822"><h3>Thermo Scientific™ Orbitrap™ IQ-X™ Tribrid™ Mass Spectrometer Specifications</h3><ul><li>Dimensions (D x W x H): 30 x 50 x 28 in. (77 x 127 x 70 cm)</li><li>Dynamic Range: &gt;5000 within a single scan</li><li>Mass Accuracy:&nbsp;<ul><li>Orbitrap mass accuracy:<ul><li>&lt;3 ppm RMS using external calibration</li><li>&lt;1 ppm RMS using internal calibration</li></ul></li></ul></li><li>Polarity Switching: One Full Cycle in 1.1 sec</li><li>Scan Rates:&nbsp;<ul><li>OTMSⁿ: Up to 40 Hz</li><li>ITMSⁿ: Up to 45 Hz</li></ul></li><li>Weight (Metric): 318 kg (700 lb.)</li><li>Mass Range: Full MS Mass Range: 50 to 2000 m/z to MSⁿ Mass Range: 40 to 2000 m/z</li><li>Max. Resolution: Up to 500,000 at m/z 200</li><li>Resolution:&nbsp;<ul><li>7500 to 500,000 (FWHM) at m/z 200</li><li>1M Option: up to 1,000,000 (FWHM) at m/z 200</li></ul></li><li>Type: Orbitrap IQ-X Tribrid MS IC</li><li>Unit Size: Each</li></ul>

Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ Mass Spectrometer

With enhanced performance and usability, the Orbitrap Eclipse Tribrid MS makes it easy to produce the high-quality data required to drive the right decisions, while expanding the breadth of your work and pushing your science beyond today’s discovery.

Introducing the Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ mass spectrometer, our newest generation instrument designed with your most difficult analytical challenges in mind. With enhanced performance and usability, the Orbitrap Eclipse Tribrid mass spectrometer makes it easy to produce the high-quality data required to drive the right decisions, while expanding the breadth of your work and pushing your science beyond today’s discovery.Obtain high confidence insights for very complex molecules with the Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ mass spectrometer. It combines industry-leading versatility and usability with the exceptional performance afforded by its built-in intelligence and revolutionary Thermo Scientific™ Tribrid™ architecture to deliver an instrument designed to address the most difficult analytical challenges.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Orbitrap_Eclipse_Tribrid_hmotnostni_spektrometr_1_622422d68a/Pragolab-Thermo-Orbitrap-Eclipse-Tribrid-hmotnostni-spektrometr-1.webp" alt="Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Orbitrap_Eclipse_Tribrid_hmotnostni_spektrometr_1_622422d68a/thumbnail_Pragolab-Thermo-Orbitrap-Eclipse-Tribrid-hmotnostni-spektrometr-1.webp 245w," sizes="100vw" width="596" height="310"><h5>This newest Tribrid platform includes:</h5><ul><li>Advanced Ion Management Technology (AIM+) with the new QR5 segmented quadrupole mass filter</li><li>Real-Time Search</li><li>Enhanced Vacuum Technology</li><li>Optional Proton Transfer Charge Reduction (PTCR)</li><li>Optional High Mass Range MSⁿ (HMRⁿ) mode</li></ul><h5>Collectively, these features make this instrument uniquely suited for:</h5><ul><li>Accurate and high-throughput full-proteome quantitation</li><li>Characterization of complex mixtures of protein or small molecule-based pharmaceuticals</li><li>Deciphering higher-order protein structures</li></ul>The Orbitrap Eclipse Tribrid MS makes it easy to tackle these difficult analyses and collect the high-quality data required to drive the right decisions, pushing your science beyond today's discovery.With its built-in intelligence and versatility, the Orbitrap Eclipse Tribrid MS makes it easy to produce the high quality data required to drive the right decisions.<ul><li>Exceptional precursor selectivity and sensitivity with the next generation quadrupole mass filter</li><li>Unmatched depth and accuracy of TMT analysis with novel Real-Time Search</li><li>High Mass Range MSⁿ (HMRⁿ) option for comprehensive analysis of native protein complexes</li><li>Unique Proton Transfer Charge Reduction (PTCR) option for simplifying complex top-down spectra</li><li>Full experimental flexibility with revolutionary instrument control</li><li>A wide range of optional functionalities for unprecedented versatility</li><li>Common user interface with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/401">Thermo Scientific™ Orbitrap Exploris™ 480</a> and <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=20&amp;manufacturerItems=3&amp;search=TSQ">TSQ™ triple quadrupole mass spectrometers</a></li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Orbitrap_Eclipse_Tribrid_hmotnostni_spektrometr_2_53ee609c22/Pragolab-Thermo-Orbitrap-Eclipse-Tribrid-hmotnostni-spektrometr-2.webp" alt="Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Orbitrap_Eclipse_Tribrid_hmotnostni_spektrometr_2_53ee609c22/thumbnail_Pragolab-Thermo-Orbitrap-Eclipse-Tribrid-hmotnostni-spektrometr-2.webp 245w," sizes="100vw" width="1452" height="710"><h3>Thermo Scientific™ Orbitrap Eclipse™ Tribrid™ Mass Spectrometer Specifications</h3><ul><li>Dimensions (D x W x H): 30 x 50 x 28 in. (77 x 127 x 70 cm)</li><li>Dynamic Range: &gt;5000 with a single OTMS spectrum</li><li>Mass Accuracy:&nbsp;<ul><li>Orbitrap mass accuracy:<ul><li>&lt;3 ppm RMS using external calibration</li><li>&lt;1 ppm RMS using internal calibration</li></ul></li></ul></li><li>Model: Tribrid MS</li><li>Polarity Switching: One Full Cycle in &lt; 1.1 sec</li><li>Scan Rates:&nbsp;<ul><li>OTMSⁿ: Up to 40 Hz</li><li>ITMSⁿ: Up to 45 Hz</li></ul></li><li>Weight (Metric): 180 kg (400 lb.)</li><li>Mass Range:&nbsp;<ul><li>Standard mass range: 50 to 2000 m/z</li><li>Mid mass range: 200 to 6000 m/z</li><li>Optomenal HMRⁿ mass range: 500 to 8000 m/z</li></ul></li><li>Max. Resolution: Up to 500,000 at m/z 200</li><li>Type: Orbitrap LC-MS</li><li>Unit Size: Each</li></ul>

Thermo Scientific Vanquish Duo UHPLC Systems

A Vanquish Duo UHPLC system enables you to run two methods simultaneously on one instrument, doubling your throughput or deepening your sample knowledge while maximizing your productivity and performance.

<h3>Optimize your productivity</h3>In today’s challenging research and production environments, you are being asked to be more productive without increasing spending or compromising quality.&nbsp;At the same time, advancements and innovations are needed to improve operational efficiency and performance. How do you accomplish this? It’s easy with the Thermo Scientific™ Vanquish™ High-throughput LC systems built for enhanced productivity. Vanquish High-throughput LC systems combine individual Vanquish components and software wizards to deliver increased throughput or detector utilization.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_8_2befa2ab8e.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_8_2befa2ab8e.jpg 191w," sizes="100vw" width="1325" height="1086"><h3>Two flow paths for maximized productivity</h3>Your laboratory may be facing increased pressure to improve working efficiency and deal with limiting resources, such as budget, space, or manpower. Vanquish High-throughput LC systems are designed to overcome these limitations by providing multiple flow paths for parallelization of specific stages of the LC run.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_2_06370d93f8.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_2_06370d93f8.jpg 245w," sizes="100vw" width="955" height="591"><h4>Unique dual technology</h4>The Vanquish platform contains two unique dual modules. Vanquish dual pumps merge two individual, low pressure mixing pumps in one housing enabling separate eluents and gradients for each pump.Vanquish dual split samplers possess two independently controlled injection units including separate injection valves and injection needles. Used in Dual LC and LC-MS workflows only, this enables high throughput and extensive sample characterization workflows.<h3>Two configurations to best serve your needs</h3>Vanquish High-throughput workflows are configured with Thermo Scientific™ Vanquish™ Core system, Thermo Scientific™ Vanquish™ Flex system or Thermo Scientific™ Vanquish™ Horizon system modules. Both workflows make use of two pumps to increase instrument productivity.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_3_77acff4bea.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: Two configurations to best serve your needs." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_3_77acff4bea.jpg 245w," sizes="100vw" width="1682" height="735"><h4>Vanquish Duo UHPLC Systems</h4><ul><li>Supported systems:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/744">Vanquish Horizon</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/743">Vanquish Flex</a></li></ul></li><li>Sampler: Dual split sampler</li><li>Detector: Two out of the complete detector portfolio</li><li>Software control:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS)</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1838">Thermo Scientific™ Standard Instrument Integration (SII)</a> for <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/627">Waters™ Empower™ 3 CDS</a></li></ul></li></ul><h4>Vanquish Tandem LC Systems</h4><ul><li>Supported systems:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/744">Vanquish Horizon</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/743">Vanquish Flex</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/397">Vanquish Core</a></li></ul></li><li>Sampler: Split sampler</li><li>Detector: One out of the complete detector portfolio and/or one mass spectrometer</li><li>Software control:<ul><li><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromeleon CDS</a></li><li>Standard System Integration for <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1758">Thermo Scientific™ Xcalibur™ software</a></li></ul></li></ul><h3>Vanquish Duo UHPLC systems</h3>A Vanquish Duo UHPLC system enables you to run two methods simultaneously on one instrument, doubling your throughput or deepening your sample knowledge while maximizing your productivity and performance. The unique Vanquish Duo UHPLC system will:<ul><li>Improve return on investment by reducing cost per sample</li><li>Increase sample throughput without changing validated methods</li><li>Increase capacity without sacrificing bench space</li><li>Accelerate your method development process</li><li>Analyze the same set of samples with multiple methods, reducing sample preparation time and maximizing sample knowledge</li></ul><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_4_4cb62100fd.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_4_4cb62100fd.jpg 245w," sizes="100vw" width="1678" height="512"><h4>What can you do with a Vanquish Duo UHPLC system?</h4><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_5_84912c40d4.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: What can you do with a Vanquish Duo UHPLC system?" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_5_84912c40d4.jpg 245w," sizes="100vw" width="1604" height="658"><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_6_f8939b888a.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: Two independent assays run simultaneously from a single sample on one LC instrument to deepen your sample knowledge." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_6_f8939b888a.jpg 245w," sizes="100vw" width="1372" height="385"><h4>Complete control with just a few clicks</h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76">Chromeleon CDS</a> delivers industry-leading ease-of-use for the Vanquish Duo system. Independently control the two channels of the Vanquish Duo system from a single interface with full traceability of all actions that is 21 CFR Part 11 compliant.<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_c2d9ed2c2c.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: Easy-to-use and intuitive system control of the Dual LC workflow within Chromeleon CDS." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_c2d9ed2c2c.jpg 245w," sizes="100vw" width="1190" height="632"><h3>See the Vanquish Duo UHPLC system</h3>The Vanquish Duo UHPLC system has been built to utilize a wide range of analytical detectors, including mass spectrometry (MS), diode array detection (DAD), charged aerosol detection (CAD), variable wavelength detection (VWD), and fluorescence detection (FLD).<img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_7_c288dc2658.jpg" alt="Thermo Scientific Vanquish Duo UHPLC Systems: See the Vanquish Duo UHPLC system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Vanquish_Duo_UHPLC_Systems_7_c288dc2658.jpg 174w," sizes="100vw" width="939" height="841"><h5>1. Vanquish Solvent Monitor</h5>Use the Vanquish Solvent Monitor to increase your regulatory compliance, productivity, and safety of your laboratory. That device guarantees that your HPLC systems will never run dry and the waste will not spill over during your analysis, reducing loss of valuable measurement time and sample material.<h5>2. Vanquish User Interface</h5>With the Vanquish User Interface, you are the master of your LC instrument. The display always shows you the key parameters of your instrument such as flow and pressure and guides you in a visual step-by-step video tutorial through key maintenance tasks.<h5>3. Versatile detection capabilities</h5>Differing molecular characteristics of your analyte, from small molecules to complex biomolecules, necessitate multiple detector methodologies. Vanquish Duo UHPLC systems can be used with any two detectors out of the broad detector portfolio including MS, DAD, VWD, FLD and CAD.<h5>4. Compatible with your software infrastructure</h5>A Vanquish Duo UHPLC system can be operated in various software environments including the latest Chromeleon software feature release, Chromeleon CDS long-term, and extended support version and Waters Empower.<h5>5. Versatile column management</h5>Greater column capacity (two 30 cm columns or a greater number of shorter columns per compartment), plus class-leading temperature range and temperature stability.<h5>6. Delivering powerful separations</h5>Run samples with two similar or different columns to increase throughput or maximize output. Setup with optional second compartment for independent column temperatures.<h5>7. Easier operation</h5>Patented tool-free Thermo Scientific™ Viper™ Fingertight Fittings with near-zero dead volume operation and ergonomic design.<h5>8. Unique Thermo Scientific™ SmartInject technology</h5>Superior retention time precision and enhanced column protection with intelligent SmartInject technology on both flow paths.<h5>9. Two proprietary injection valves</h5>Two separate injection valves with no shared fluidics allowing full application flexibility, including individual eluents, wash liquids and loop sizes.<h5>10. Easier sample handling</h5>Automated barcode reader to eliminate tedious rack configuration.<h5>11. Higher sample capacity</h5>High sample capacity is standard (four plates versus two plates on industry average). Increase capacity further with the optional Thermo Scientific™ Vanquish™ Charger module.<h5>12. Accurate flow for more data confidence</h5>The flow is delivered by a dual pump offering two truly individual devices in a single housing with ternary gradient proportioning.<h5>13. Simple maintenance</h5>Module maintenance is reduced to a minimum and can be worked on without instrument de-stacking, plus smart light bars on the front of the system provide instant system status update.<h5>14. Keep the lab tidy</h5>The built-in drawer stores accessories, related documents, or any other useful material for the system.<h3>Thermo Scientific LC portfolio overview</h3><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_LC_portfolio_overview_2db5044366.jpg" alt="Thermo Scientific LC portfolio overview." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_LC_portfolio_overview_2db5044366.jpg 188w," sizes="100vw" width="795" height="660">

Thermo Scientific Vanquish FLEX UHPLC System

Whether you are analyzing innovative biotherapeutics or novel chemical medicines, method development with Thermo Scientific™ Vanquish™ Flex™ UHPLC system has never been easier.

Thermo Scientific Vanquish Horizon UHPLC System

Designed with innovative technology and fine detail, the Vanquish Horizon UHPLC delivers outstanding precision, sensitivity, and simplicity for unmatched performance and robustness.

Thermo Scientific Dionex AutoTrace 280 Solid-Phase Extraction Instrument

Extract analytes of interest from large volume aqueous samples easily and efficiently with the Thermo Scientific™ Dionex™ AutoTrace™ 280 Solid-Phase Extraction (SPE) Instrument.

Extract analytes of interest from large volume aqueous samples easily and efficiently with the Thermo Scientific™ Dionex™ AutoTrace™ 280 Solid-Phase Extraction (SPE) Instrument.&nbsp;The AutoTrace 280 automates all four steps of SPE (conditioning, loading, rinsing, and eluting), reducing solvent consumption and improving recovery and reproducibility. Boost productivity and reduce cost of analysis by simultaneously processing up to six samples in 2-3 hours with only 15 minutes of operator involvement. The AutoTrace 280 meets requirements in US EPA methods including the 500 and 600 series.<h5>Improved reliability and recovery</h5><ul><li>Automated SPE minimizes operator intervention</li><li>Positive pressure loading and elution of samples and solvents provide constant flow for improved analytical precision</li></ul><h5>Flexibility in operation</h5><ul><li>Loads sample volumes from 20 mL to 4 L</li><li>Compatible with 1, 3, and 6 mL cartridges and with 47 mm SPE disks</li><li>Automatically conditions, rinses, and elutes SPE cartridges with a choice of five solvents</li><li>Offers a choice of six different collection vial racks</li></ul><h5>Improved laboratory safety</h5><ul><li>Minimal sample handling reduces operator exposure to hazardous chemicals</li><li>No hood required</li></ul><h5>Enhanced laboratory productivity and reduced costs</h5><ul><li>Unattended operation</li><li>Batch processing of up to 6 samples</li><li>Reduced solvent usage</li><li>Segregates aqueous and solvent waste using separate waste lines for efficient, cost-effective waste handling</li></ul><h5>Supports a range of matrices and applications</h5><ul><li>Ability to process samples containing suspended solids</li><li>Meets requirements for solid-phase extraction for U.S. EPA methods including 500 and 600 series</li></ul><h5>Recommended use</h5><ul><li>Analyze prepared samples with Thermo Scientific LC or GC systems for a fully integrated workflow</li></ul><h4>Specifications</h4><ul><li>Instrument Type: Automated Solid Phase Extraction (SPE) System</li><li>Application: For use with 47 mm SPE disks</li><li>Model Description: AutoTrace 280 SPE System</li></ul><h5>Performance &amp; Operating Details</h5><ul><li>Disk Compatibility: Designed for 47 mm SPE disks</li><li>Pressure Range:<ul><li>Output: 0 to 30 psi (0 to 1.4 bar)</li><li>Input: Up to 100 psi (6.9 bar) maximum</li></ul></li><li>Voltage: 100–240 V ±10%</li><li>Frequency: 47–63 Hz</li></ul><h5>Physical Specifications</h5><ul><li>Dimensions (D × W × H): 57 × 63.5 × 69 cm</li><li>Unit Size: Each</li></ul>

Products from Thermo Fisher Scientific - page 15

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