<p><strong>Per- and polyfluoroalkyl substances (PFAS) have earned the moniker "forever chemicals" due to their extreme persistence in the environment. Their detection is crucial for protecting public health and the environment as these synthetic compounds continue to pose significant challenges worldwide. This comprehensive exploration examines why PFAS detection matters, current detection methods, and future directions in addressing PFAS contamination.</strong></p><h3><strong>Understanding PFAS and Their Health Impacts</strong></h3><p>PFAS are a class of synthetic organic compounds with diverse structures, properties, and uses. Despite their diversity, all PFAS contain perfluoroalkyl moieties that are extremely resistant to environmental and metabolic degradation [1]. This high persistence is a defining characteristic that makes PFAS management particularly challenging.</p><h3><strong>Documented Health Effects</strong></h3><p>Current scientific research has linked PFAS exposure to numerous adverse health outcomes:</p><ul><li>Reproductive effects including decreased fertility and increased high blood pressure in pregnant women [8]</li><li>Developmental effects in children such as low birth weight, accelerated puberty, and behavioral changes [8]</li><li>Reduced immune system function, including decreased vaccine response</li><li>Interference with natural hormones and endocrine disruption</li><li>Increased cholesterol levels and obesity risk</li><li>Increased risk of several cancers, including prostate, kidney, testicular, oral cavity/pharynx, brain, and endocrine cancers [3]</li></ul><p>A 2023 study linked PFAS-contaminated water with up to a <strong>33% increase in cancer incidence</strong> in affected areas [3]. The study compared regions with elevated PFAS levels to cancer data from the National Cancer Institute, finding higher incidences of various cancers after controlling for factors like smoking and obesity.</p><h3><strong>Environmental Persistence and Contamination</strong></h3><p>The extreme persistence of PFAS represents a fundamental concern for environmental management. PFAS are considered the most environmentally persistent substances among organic chemicals [7]. This persistence means that even if all PFAS uses were immediately phased out, existing contamination would continue to affect ecosystems and water supplies for generations.</p><p>A 2023 study at a military fire training site estimated that PFAS contamination will persist for centuries without remediation [7]. The research found that terminal PFAS still exceed regulatory limits by 2000-fold decades after aqueous film-forming foam (AFFF) use ceased, with precursors accounting for around half of the extractable organofluorine across years.</p><h3><strong>Current Detection Methods</strong></h3><h4><strong>EPA Standardized Methods</strong></h4><p>The<strong> Environmental Protection Agency (EPA</strong>) has developed several standardized methods for PFAS detection, each with specific applications and capabilities:</p><h5><strong>EPA Method 533</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/epa-533-drying-down-pfas-samples-after-spe"><strong>EPA Method 533</strong></a> focuses on "short chain" PFAS with carbon chain lengths of<strong> C4 to C12</strong>. Released in December 2019, this method complements Method 537.1 and includes several key features:</p><ul><li>Uses isotope dilution quantification approach with extracted internal standards, which reduces overall analytical uncertainty</li><li>Employs weak anion exchange solid phase extraction cartridges as opposed to polystyrene divinylbenzene used in 537.1</li><li>Can analyze 25 PFAS compounds, including additional short-chain PFAS that were not apart of Method 537.1</li><li>Allows for longer holding times: 28 days to extraction and 28 days to analyze (compared to 14 days to extraction in Method 537.1)</li><li>Uses ammonium acetate as a preservative (versus Trisma in Method 537.1) [1]</li></ul><h5><strong>EPA Method 537/537.1</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/sample-concentration-epa-method-537-pfas-determination"><strong>EPA Method 537 </strong></a>was first published in 2009 for the determination of 14 PFAS in drinking water [6]. It was later updated to Method 537.1 in 2018 (with editorial updates in 2020) to expand its capabilities:</p><ul><li>Uses<a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/what-is-solid-phase-extraction-spe"><strong> solid phase extraction (SPE) </strong></a>and<a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/preparing-samples-for-lc-ms/ms-analysis"><strong> liquid chromatography/tandem mass spectrometry (LC-MS/MS)</strong></a></li><li>Method 537.1 expanded detection to 18 PFAS compounds, including HFPO-DA (one component of GenX technology)</li><li>Utilizes styrene-divinylbenzene (SDVB) media for extraction</li><li>Requires samples to be extracted within 14 days and analyzed within 28 days</li><li>Methanol is used to elute the extracts. This should then be reconstituted with a 96:4 methanol:water mixture [1]</li></ul><p>Together, Methods 533 and 537.1 can detect a total of <strong>29 unique PFAS compounds in drinking water </strong>and are approved for monitoring under the fifth Unregulated Contaminant Monitoring Rule (UCMR 5) and the PFAS National Primary Drinking Water Regulation [1] [3].</p><h5><strong>EPA Method 1633</strong></h5><p><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/preparing-diverse-sample-matrices-for-epa-method-1633"><strong>EPA Method 1633</strong></a>, released in 2024, represents a significant advancement in PFAS analysis:</p><ul><li>Developed for the analysis of <strong>40 PFAS compounds </strong>in various matrices, including surface water, groundwater, wastewater, soil, biosolids, sediment, landfill leachate, and fish tissue</li><li>Expands beyond the drinking water focus of Methods 533 and 537.1</li><li>Provides a standardized approach that may replace modified drinking water methods (i.e., modified EPA 537) that were previously used for non-drinking water matrices [1]</li></ul><h4><strong>Conventional Analytical Techniques</strong></h4><p>The gold standard for PFAS analysis involves chromatographic techniques coupled with mass spectrometry:</p><ul><li>Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) is the most widely used method for PFAS analysis, offering high sensitivity and specificity [1]</li><li>High-Resolution Mass Spectrometry (HRMS) allows for rapid detection and identification of PFAS species at very low concentrations [5]</li></ul><p>These techniques can detect PFAS at parts per trillion (ppt) levels, which is essential given the low concentrations at which PFAS can cause health effects [1]. However, these methods require sophisticated equipment, specialized training, and significant financial resources, making them inaccessible in many regions, particularly in developing countries.</p><h4><strong>Emerging Detection Technologies</strong></h4><p>Several innovative approaches are being developed to address the limitations of conventional methods:</p><ul><li>Electrochemical biosensors using modified electrodes have shown promise for selective PFAS detection with low detection limits [2]</li><li>Surface-Enhanced Raman Spectroscopy (SERS) uses metallic nanoparticles and can be made into a portable method for on-site testing [1]</li><li>Molecular imprinted polymers (MIPs) offer thermal and physical stability, reusability, and low-cost synthesis for PFAS detection [6]</li></ul><p>These emerging technologies aim to provide more accessible, field-deployable, and cost-effective alternatives to traditional laboratory-based methods.</p><h3><strong>Challenges in PFAS Detection</strong></h3><h4><strong>Analytical Challenges</strong></h4><p>Detecting PFAS presents several technical challenges:</p><ul><li>The ubiquity of PFAS in laboratory equipment and accessories can lead to background contamination when measuring at parts-per-trillion levels [1]</li><li>Many components in liquid chromatographs, mass spectrometers, and solid-phase extraction systems contain materials that can leach PFAS compounds [9]</li><li>The vast number of PFAS (thousands of compounds) makes comprehensive detection difficult, as analytical standards are only available for a small subset [1]</li><li>Complex matrices like food and environmental samples require sophisticated sample preparation techniques</li></ul><h4><strong>Global Disparities in Detection Capabilities</strong></h4><p>Access to PFAS detection technology varies significantly worldwide:</p><ul><li>Many developing regions, particularly in Africa, lack adequately equipped laboratories with the necessary instrumentation to detect and measure PFAS</li><li>There is often a scarcity of qualified professionals with experience in PFAS analysis in these regions</li><li>The high cost of acquiring and maintaining sophisticated analytical instruments presents a substantial obstacle to conducting extensive PFAS investigations in resource-limited settings [1]</li><li>Competing priorities such as infectious diseases, poverty, and food security often divert attention and resources from environmental pollutants like PFAS</li></ul><h4><strong>Regulatory Landscape and Compliance</strong></h4><p>The regulatory framework for PFAS is evolving rapidly worldwide:</p><ul><li>The EPA finalized Section 8(a)(7) of the Toxic Substances Control Act in September 2024, requiring manufacturers and importers to report on their use of PFAS since 2011 [10]</li><li>Electronic reporting for PFAS will open on July 11, 2025, with final reporting deadlines in 2026</li><li>Companies must report detailed information including chemical identity, production volumes, industrial and consumer products, worker exposure, and disposal methods [10]</li></ul><p>These regulations are driving demand for more effective and accessible PFAS detection methods to ensure compliance and protect public health.</p><h3><strong>Future Directions in PFAS Detection</strong></h3><h4><strong>Technological Advancements</strong></h4><p>The future of PFAS detection lies in developing more accessible, sensitive, and comprehensive methods:</p><ul><li>Non-targeted screening methods that can identify unknown PFAS compounds without requiring analytical standards for each specific compound</li><li>Total fluorine analysis techniques like Adsorbable Organic Fluorine and Total Oxidizable Precursor Assay that can quantify the presence of fluorine atoms within a sample [1]</li><li>Portable sensors and field-deployable technologies that enable on-site monitoring and rapid response to contamination events</li><li>AI-driven solutions that can improve data analysis and interpretation for complex PFAS mixtures</li></ul><h4><strong>Collaborative Approaches</strong></h4><p>Addressing the global challenge of PFAS detection requires coordinated efforts:</p><ul><li>International partnerships between researchers in developed and developing regions to enhance expertise and capacity building</li><li>Standardization of analytical methods to ensure consistency and comparability of results across different laboratories and regions</li><li>Open data sharing and collaboration across countries to leverage collective knowledge and resources</li><li>Integration of PFAS monitoring into broader environmental and public health surveillance systems</li></ul><h3><strong>Conclusion</strong></h3><p>The detection of PFAS is not merely a technical challenge but a critical public health and environmental imperative [1]. As these "forever chemicals" continue to persist in our environment, developing effective, accessible, and comprehensive detection methods becomes increasingly important. By advancing detection technologies, strengthening regulatory frameworks, and fostering global collaboration, we can better understand, monitor, and ultimately mitigate the impacts of PFAS contamination.</p><p>The EPA's standardized methods (533, 537.1, and 1633) provide crucial tools for monitoring PFAS in various environmental matrices, but continued innovation is needed to address the full spectrum of PFAS compounds and to make detection more accessible globally [1] [6]. The path forward requires sustained investment in research and development, capacity building in resource-limited settings, and a commitment to environmental justice that ensures all communities have access to the tools and information needed to protect themselves from PFAS exposure. Only through such comprehensive approaches can we hope to address the complex challenges posed by these persistent pollutants.</p><p><span>Be sure to check out our other installments of our&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/introducing-our-environmental-contaminants-series-making-sense-of-the-alphabet-soup"><span>Environmental Contaminant Series</span></a><span>&nbsp;covering&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-persistent-organic-pollutants-pops"><span>Persistent Organic Pollutants (POPs)</span></a><span>,&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-polycyclic-aromatic-hydrocarbons-pahs"><span>Polycyclic Aromatic Hydrocarbons (PAHs)</span></a><span>,&nbsp;</span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-semi-volatile-organic-compounds-svocs"><span>Semi-Volatile Organic Compounds (SVOCs)</span></a><span>, and </span><a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/the-importance-of-detecting-polychlorinated-biphenyls-pcbs"><span>Polychlorinated Biphenyls (PCBs)</span></a><span>.</span></p>

The Importance of Detecting Per- and Polyfluoroalkyl Substances (PFAS)

<p><strong>Scientists at CEITEC Brno University of Technology have developed microscopic robots that could one day accelerate beer production and simplify food quality control. The magnetically controlled biobots can actively mix liquids during fermentation, speed up the process, and separate themselves from the finished product once fermentation is complete. The results of the research, carried out by Professor Martin Pumera’s team, were published in the journal </strong><i><strong>ACS Nano</strong></i><strong>.</strong></p><p><i>“When people hear the word ‘robot’ today, they often imagine an electronic device. In reality, however, a robot can be any system capable of autonomously performing a specific task,” </i>explains <strong>Martin Pumera of CEITEC Brno University of Technology</strong>.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_7d9ff82875.jpeg" alt="CEITEC BUT/Jakub Rozboud: CEITEC Microrobots Could Speed Up Beer Production and Food Quality Control: Martin Pumera in his lab at CEITEC BUT." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_7d9ff82875.jpeg 235w," sizes="100vw" width="1600" height="1067"></p><p>The research team created so-called biobots—biohybrid microrobotic capsules containing brewer’s yeast and magnetic nanoparticles. When the yeast produces carbon dioxide during fermentation, the resulting bubbles cause the biobots to move up and down through the liquid. This naturally mixes the contents of the vessel and makes fermentation more efficient. Compared with conventional static particles, the biobots can therefore accelerate chemical processes that are important in food production.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_4_af5fd4611f.jpg" alt="CEITEC BUT/Martin Pumera's archive: CEITEC Microrobots Could Speed Up Beer Production and Food Quality Control: Hematite microrobot (image for illustrative purposes)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_4_af5fd4611f.jpg 209w," sizes="100vw" width="1600" height="1192"></p><p>Another major advantage of the technology is that the biobots can be easily separated from the finished beverage. Thanks to the magnetic particles they contain, they can be controlled with a magnetic field and removed once fermentation is complete, eliminating the need for additional filtration. The researchers also demonstrated that the biobots can be reused over several production cycles.</p><p><i>“Unlike conventional static particles, microrobots actively move throughout the entire volume of the liquid, allowing them to cover a larger area and make the whole process more efficient. At the same time, they also facilitate the automation of production,”</i> adds Martin Pumera. The team is currently discussing potential applications of the technology with a major European brewery.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_3_e8e5a3a55a.jpg" alt="CEITEC BUT/Martin Pumera's archive: CEITEC Microrobots Could Speed Up Beer Production and Food Quality Control: g-C₃N₄ microrobots (image for illustrative purposes)." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_3_e8e5a3a55a.jpg 158w," sizes="100vw" width="1476" height="1460"></p><p>Martin Pumera’s group has long been exploring the use of microrobots and advanced materials in the food industry. In the past, for example, the team developed a flexible sensor for smart packaging capable of detecting spoiled fish. The new biobots therefore represent another step towards more advanced methods of food quality and safety control.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_2_75c7fed958.jpeg" alt="CEITEC BUT/ACS Nano: CEITEC Microrobots Could Speed Up Beer Production and Food Quality Control: ACS Nano - cover featuring article by Martin Pumera et al." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Mikroroboti_z_CEITEC_mohou_urychlit_vyrobu_piva_i_kontrolu_kvality_potravin_2_75c7fed958.jpeg 117w," sizes="100vw" width="1600" height="2128"></p>

 CEITEC Microrobots Could Speed Up Beer Production and Food Quality Control 

<p><strong>In this episode of ‪ChromatographyTalk‬, ‪Organomation‬ General Manager David Oliva sits down with Michelle Taylor, Editor-in-Chief of LabCompare, to go behind the scenes of their groundbreaking two-part documentary series on PFAS (per- and polyfluoroalkyl substances).</strong></p><p>The conversation kicks off with a startling revelation: many of the world’s leading PFAS experts have completely stopped eating seafood due to high contamination levels discovered during testing. From there, we dive deep into the technical and regulatory challenges facing today's analytical laboratories.</p><h4><strong>In this episode, we discuss:</strong></h4><ul><li><strong>The Laboratory Throughput Crisis:</strong> Why labs are currently "overwhelmed with samples" and how tiered testing—using single quad instruments for screening before moving to triple quads—is helping to manage capacity without sacrificing sensitivity.</li><li><strong>The Battle Against Background Contamination:</strong> Why PTFE-free (PFAS-free) laboratory equipment is no longer optional when trying to detect "forever chemicals" at the parts-per-trillion and parts-per-quadrillion levels.</li><li><strong>Complex Matrices (Seafood &amp; Packaging): </strong>The technical hurdles of analyzing high-lipid samples like fish and the rising demand for migration testing as states like Rhode Island begin to phase out PFAS in food packaging.</li><li><strong>Global Regulatory Shifts:</strong> A look at the "dual compliance model" required for labs supporting international exporters, especially with the European Union’s stricter enforcement compared to the U.S. monitoring approach.</li><li><strong>The "Grand Challenge" of Unknowns: </strong>How EPA Method 1621 (Total Organic Fluorine) is helping labs close the mass balance gap and why the next generation of bench chemists must embrace *AI and data science* to manage the massive datasets generated by high-resolution mass spectrometry.</li><li><strong>PFAS Destruction vs. Remediation:</strong> &nbsp;The promising (and problematic) methods for breaking the carbon-fluorine bond, and why incineration may inadvertently be spreading shorter-chain PFAS into the air.</li></ul><p>Whether you are a lab manager looking to future-proof your workflow or a chemist navigating the ever-evolving landscape of EPA Method 1633, this episode provides essential insights into the most pressing environmental crisis of our time.</p><h3><strong>Video Transcription</strong></h3><h4><strong>Michelle Taylor: PFAS Testing Is Becoming a Much Bigger Analytical Challenge</strong></h4><p><strong>PFAS analysis has rapidly evolved from a specialized environmental testing problem into a much broader challenge involving drinking water, food, packaging, laboratory contamination, international regulation, data analysis, and even destruction technologies. In an interview with Michelle Taylor, Editor-in-Chief of Labcompare, the discussion explored what laboratories are learning from the latest PFAS research—and why the analytical demands are likely to continue growing.</strong></p><p>Taylor leads editorial content for <strong>Labcompare</strong>, an online resource covering analytical laboratory instrumentation, products, and scientific developments. Among the projects she considers particularly important are two long-form documentaries produced by Labcompare examining per- and polyfluoroalkyl substances (PFAS), first through drinking water and subsequently through food.</p><p>The documentaries brought together subject-matter experts working across PFAS analysis and exposed some of the practical realities laboratories now face: rapidly changing regulations, extremely low detection limits, complex matrices, contamination risks, and sample volumes that can overwhelm laboratory capacity.</p><h4><strong>From drinking water to seafood</strong></h4><p>One of the most memorable findings for Taylor came during production of the second documentary, which focused on PFAS in food.</p><p>Several experts interviewed for the project told her they had stopped eating seafood, in some cases many years earlier, because of concerns surrounding contamination. For Taylor, the consistency and immediacy of those responses illustrated how closely analytical research can intersect with everyday decisions.</p><p>Seafood also demonstrates why PFAS testing can become analytically difficult.</p><p>Fish and other high-lipid samples require effective extraction to release the analytes, followed by rigorous cleanup to remove fats. According to the experts Taylor interviewed, the cleanup step is particularly critical because residual lipids can damage LC columns and create severe matrix interferences.</p><p>Laboratories are therefore using approaches such as enhanced matrix removal and carbon- or silica-based sorbents to reduce the lipid content of extracts before instrumental analysis. The goal is not simply obtaining sufficient recovery, but producing an extract clean enough to maintain analytical performance and laboratory throughput.</p><h4><strong>How laboratories are handling the PFAS sample burden</strong></h4><p>The analytical sensitivity now required for PFAS testing presents another challenge: laboratories may need to measure compounds at <strong>parts-per-trillion levels</strong> while processing growing numbers of samples.</p><p>Automation has therefore become increasingly important, particularly during sample preparation, where repetitive manual procedures can otherwise create a major bottleneck.</p><p>Taylor also described a <strong>tiered analytical strategy</strong> being used by some laboratories. A less demanding measurement can first be used for screening, while samples generating a positive result are subsequently transferred to a more sensitive platform, such as triple-quadrupole mass spectrometry, for confirmation and quantitation.</p><p>This type of workflow can help laboratories concentrate their highest-performance instrumentation on the samples that actually require it rather than applying the most intensive analysis to every incoming sample.</p><p>The broader principle is likely to become increasingly important as PFAS testing expands: laboratories must find ways to increase throughput without sacrificing the sensitivity demanded by regulatory methods.</p><h4><strong>When the laboratory itself becomes a source of PFAS</strong></h4><p>At trace concentrations, contamination introduced during sample preparation or measurement can become comparable to the concentration being determined.</p><p>This makes the materials used throughout the analytical workflow particularly important.</p><p>Taylor emphasized that PFAS laboratories must maintain continuous awareness of potential contamination from <strong>solvents, water, tubing, containers, and other laboratory components</strong>. Equipment containing fluoropolymers such as PTFE may be problematic in certain PFAS workflows because background contamination can contribute to false positives or elevated blanks.</p><p>As detection limits move lower, dedicated PFAS-compatible or fluoropolymer-free laboratory equipment becomes increasingly valuable.</p><p>Taylor described manufacturers offering clearly identified PFAS-free configurations as an important response to this problem. Rather than forcing laboratories to investigate the material composition of each component individually, dedicated configurations can simplify method implementation and reduce uncertainty about potential background sources.</p><p>For laboratories already dealing with demanding workflows and large sample loads, eliminating potential contamination before it occurs can save considerable troubleshooting time.</p><h4><strong>Food packaging could drive the next major wave of testing</strong></h4><p>PFAS concerns are not limited to the food itself.</p><p>The interview also examined <strong>food-contact materials</strong>, including takeout containers and other packaging from which PFAS may migrate into food. State-level restrictions in the United States are already beginning to affect the materials manufacturers can use.</p><p>For contract laboratories, this creates the possibility of another significant increase in demand for compliance and migration testing.</p><p>Taylor’s recommendation is straightforward: laboratories should follow proposed regulations before they become final.</p><p>Waiting until a new requirement takes effect can leave a laboratory simultaneously trying to acquire instrumentation, establish methods, train staff, and respond to customer demand. Monitoring regulatory agencies, scientific meetings, and industry discussions earlier gives laboratories time to prepare analytical capabilities before the testing requirement becomes urgent.</p><p>She expects PFAS restrictions in food packaging to continue developing first through a patchwork of individual state regulations. Once a sufficient number of states adopt restrictions, however, the economics may increasingly encourage suppliers to move toward PFAS-free materials regardless of whether every jurisdiction requires them.</p><p>A national standard could eventually follow that transition.</p><h4><strong>One sample, two regulatory environments</strong></h4><p>International food exporters face another complication: <strong>PFAS requirements are not necessarily the same between the United States and European Union</strong>.</p><p>Taylor noted that laboratories serving both markets may effectively need to operate under a dual-compliance model.</p><p>In the interview, she highlighted EU requirements targeting specific PFAS—including <strong>PFOS, PFOA, PFNA, and PFHxS</strong>—at very low concentrations in certain foods, while the U.S. approach has historically involved a different combination of monitoring programs, evolving compound lists, and import-related requirements.</p><p>For laboratories supporting international customers, this means more than simply selecting a different reporting limit.</p><p>Different markets may require different target lists, methods, documentation, auditing, and compliance procedures. Laboratories therefore need analytical platforms capable of ultratrace measurements while also maintaining the operational flexibility to support multiple regulatory frameworks.</p><p>That additional complexity also carries a practical cost: performing different protocols for different jurisdictions means more staff time, additional workflow management, and potentially greater instrument demand.</p><h4><strong>Total fluorine screening can help laboratories decide what to analyze next</strong></h4><p>Targeted LC-MS/MS methods are highly sensitive, but they only measure compounds included in the analytical panel.</p><p>This creates an important question: <strong>what about fluorinated substances that are present but are not included in the targeted method?</strong></p><p>The interview discussed <strong>EPA Method 1621</strong>, which uses a broader fluorine-based screening approach. Taylor described this type of measurement as useful for helping laboratories assess the gap between compounds captured by targeted LC-MS/MS methods and the broader amount of organofluorine present in a sample.</p><p>Such screening can also become part of a tiered workflow.</p><p>For applications such as food packaging, laboratories could initially use a broader fluorine measurement to determine whether a sample warrants further investigation. Positive or suspicious samples could then move to more selective and sensitive targeted analysis for identification and quantitation.</p><p>Non-targeted high-resolution mass spectrometry can add another layer by revealing compounds outside conventional target lists.</p><p>Together, these approaches create a funnel from broad screening toward increasingly detailed characterization rather than attempting the most comprehensive analysis on every sample from the outset.</p><h4><strong>PFAS analysis is becoming a data problem too</strong></h4><p>High-resolution mass spectrometry can generate enormous datasets containing signals from large numbers of known and unknown compounds.</p><p>As a result, Taylor believes the role of the analytical chemist is changing.</p><p>Strong laboratory skills remain essential, but scientists increasingly need <strong>data literacy</strong> as well. Understanding complex datasets, working with advanced software, and interacting effectively with artificial intelligence and machine-learning tools are becoming important parts of modern analytical work.</p><p>Taylor does not see this change primarily as replacing scientific expertise.</p><p>Instead, she compares it with earlier laboratory automation: repetitive or technically demanding tasks can increasingly be handled by software, allowing scientists to spend more time interpreting results and making decisions.</p><p>AI may also make sophisticated analytical information more accessible. A less experienced mass spectrometry user could potentially receive explanations of complex data through software capable of presenting results in natural language, reducing dependence on a single specialist being immediately available.</p><p>There is another potential advantage beyond speed.</p><p>Machine-learning systems can recognize patterns across large datasets that may be difficult or impossible for an individual scientist to detect manually. As analytical datasets become larger and multidimensional, that pattern-recognition capability could become increasingly valuable.</p><h4><strong>Finding PFAS is only the first half of the problem</strong></h4><p>For years, much of the PFAS discussion has focused on answering two questions:</p><ul><li><strong>Are PFAS present, and how much is there?</strong></li></ul><p>The next challenge is considerably harder: <strong>how do we actually remove or destroy them?</strong></p><p>Taylor described this as an expanding research field that will increasingly involve analytical laboratories.</p><p>The strength of the carbon-fluorine bond makes PFAS destruction difficult. Some treatment approaches seek to break this bond and achieve complete defluorination, but incomplete destruction can create another analytical problem.</p><p>For example, thermal treatment may transform longer-chain PFAS into shorter-chain fluorinated compounds rather than eliminating them completely. Those products may then enter another environmental compartment, including atmospheric emissions.</p><p>Consequently, laboratories studying PFAS destruction must do more than measure disappearance of the original compound. They also need to determine whether <strong>fluorinated transformation products or other byproducts remain</strong>.</p><p>Analytical chemistry therefore has two roles: monitoring PFAS contamination and demonstrating whether remediation technologies truly destroy the substances they are intended to remove.</p><h4><strong>The PFAS problem is expanding beyond water and food</strong></h4><p>The first two Labcompare documentaries focused primarily on <strong>water and food</strong>, two matrices already receiving substantial regulatory and public attention.</p><p>But Taylor does not expect the story to end there.</p><p>If Labcompare produces another PFAS documentary, she sees <strong>PFAS in air</strong> as a likely subject. Discussions with experts during earlier filming repeatedly raised atmospheric contamination, including both direct environmental occurrence and emissions potentially associated with treatment or destruction processes.</p><p>The progression illustrates how quickly the PFAS field is expanding.</p><p>Drinking water regulation accelerated analytical development. Food testing introduced more difficult matrices and new exposure pathways. Packaging is creating another compliance challenge. Environmental remediation raises questions about destruction products. Atmospheric monitoring could become another significant frontier.</p><p>For laboratories already working with chromatography and mass spectrometry, Taylor’s message is essentially to be prepared—even organizations that do not currently consider themselves “PFAS laboratories” may eventually become involved.</p><h4><strong>An analytical field that is still changing rapidly</strong></h4><p>Perhaps the strongest theme running through the interview is that PFAS analysis has no fixed endpoint yet.</p><p>Methods continue to evolve. Regulations change. Target compound lists expand. Instrument sensitivity improves. Laboratories discover new sources of background contamination, while researchers identify additional exposure pathways and investigate new destruction technologies.</p><p>Taylor compares the situation to earlier periods of rapid analytical development, such as the evolution of forensic DNA analysis: each technological advance reveals more information, which in turn creates new questions and new analytical requirements.</p><p>That makes preparation particularly important.</p><p>Laboratories cannot predict every future regulation, but they can follow proposed requirements, develop flexible workflows, invest in contamination control and data capabilities, and understand how their existing chromatography and mass spectrometry expertise could be applied to emerging PFAS challenges.</p><p>The analytical problem is no longer simply detecting a group of “forever chemicals.”</p><p>It is becoming a much larger question of <strong>how we identify them, quantify them, prevent contamination during analysis, understand their movement through food and the environment, comply with evolving regulations, and ultimately prove that they have actually been destroyed.</strong></p><blockquote><p><strong>This text has been automatically transcribed from a video presentation using AI technology. It may contain inaccuracies and is not guaranteed to be 100% correct.</strong></p></blockquote><blockquote><h4><strong>Concentrating on Chromatography Podcast</strong></h4><p>Dive into the frontiers of chromatography, mass spectrometry, and sample preparation with host David Oliva. Each episode features candid conversations with leading researchers, industry innovators, and passionate scientists who are shaping the future of analytical chemistry. From decoding PFAS detection challenges to exploring the latest in AI-assisted liquid chromatography, this show uncovers practical workflows, sustainability breakthroughs, and the real-world impact of separation science. Whether you’re a chromatographer, lab professional, or researcher you'll discover inspiring content!</p><p>You can find <strong>Concentrating on Chromatography Podcast </strong>in podcast apps:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://open.spotify.com/show/1wZg67rCjoGju4yhqxI3tL"><strong>Spotify</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podcasts.apple.com/tz/podcast/concentrating-on-chromatography/id1788429185"><strong>Apple podcast</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://podscan.fm/podcasts/concentrating-on-chromatography"><strong>podscan</strong></a></li></ul><p>and on <a target="_blank" rel="noopener noreferrer" href="https://www.youtube.com/@ChromatographyTalk/videos"><strong>YouTube channel</strong></a></p></blockquote>

PFAS in Water, Food & Packaging: Michelle Taylor on the "Forever Chemicals" Documentary Series

Article

Scientists

Environment

Food

Water

Interview

Science and research

Video

Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Bioanalytic QTOF quantitative and qualitative analysis training

The purpose of the training is to introduce users to the capabilities of the LC-HR-MS/MS (QTOF) system in quantitative and qualitative analysis.

<h4><strong>BASIC INFORMATION</strong></h4><ul><li>TITLE:&nbsp;<strong> QTOF quantitative and qualitative analysis training</strong></li><li>CATEGORY: <strong>LC-MS/MS training</strong></li><li>LOCATION: <strong>Lodz, PL</strong></li><li>TRAINING TIME: <strong>3 days</strong></li><li>NUMBER OF PARTICIPANTS: <strong>up to 5 people</strong></li><li>EQUIPMENT:<strong> SCIEX</strong><span class="ts-pf-details-content"><strong> </strong></span><strong>QTOF LC-MS/MS</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Bioanalytic_Bioanalytic_QTOF_quantitative_and_qualitative_analysis_training_af1620ae8c.jpg" alt="Bioanalytic: Bioanalytic QTOF quantitative and qualitative analysis training." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Bioanalytic_Bioanalytic_QTOF_quantitative_and_qualitative_analysis_training_af1620ae8c.jpg 221w," sizes="100vw" width="1000" height="707"></p><h4><strong>TRAINING COURSE DESCRIPTION</strong></h4><p><strong>Qualitative and quantitative analysis of QTOF</strong> - the training is designed for laboratory personnel using <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library?instrumentationItems=30&amp;mainauthorItems=55"><strong>high-resolution (HR) LC-MS/MS</strong></a> systems for qualitative and quantitative analysis. The following topics are covered during the training:</p><ul><li><strong>QTOF spectrometer calibration</strong></li><li><strong>Targeted and untargeted methods</strong></li><li><strong>Quantitative analysis (TOF MS, MRMhr)</strong></li><li><strong>Qualitative and quantitative analysis - DDA (IDA) vs DIA (SWATH) methodology</strong></li><li><strong>Software and its use in high-resolution data analysis</strong></li><li><strong>Reporting of results</strong></li></ul><p>The purpose of the training is to introduce users to the capabilities of the LC-HR-MS/MS (QTOF) system in quantitative and qualitative analysis. To point out the advantages of high resolution in identifying or confirming the presence of substances in a sample and also the strengths of modern QTOF systems in parallel quantitative analysis.</p><h3><strong>Training program</strong></h3><h4><span style="font-size:20px;"><strong>Day I</strong></span></h4><h5><strong>Theoretical part</strong></h5><ul><li>The principle of operation and capabilities of the QTOF system</li><li>Comparison of typical analytical procedures and their application</li><li>Targeted and quantitative analysis (TOF MS vs MRMhr)</li><li>DDA (IDA) vs DIA (SWATH) methodology.</li><li>Supporting software - Molecule Profiler, ACD Labs, MarkerView</li><li>General principles of compound fragmentation</li></ul><h4><span style="font-size:20px;"><strong>Day II</strong></span></h4><p><strong>Objective</strong> - to develop methods for quantitative analysis, confirmation or search for metabolites of a known substance, general characterization of the sample.</p><h5><strong>Practical part:</strong></h5><ul><li>Creation and optimization of the MRMhr targeted method</li><li>Creation and optimization of a non-targeted method IDA</li><li>Creation and optimization of the non-targeted method SWATH</li><li>Data acquisition (overnight)</li></ul><h4><span style="font-size:20px;"><strong>Day III</strong></span></h4><p><strong>Objective</strong> - quantitative analysis, confirmation of the presence or identification of metabolites of a known substance, general characterization of the sample (identification of compounds present in the sample), profiling.</p><h5><strong>Practical part:</strong></h5><ul><li>Quantitative analysis - TOF MS vs MRMhr</li><li>Methods for searching and analyzing data</li><li>IDA vs SWATH data</li><li>Manual search and identification</li><li>Automated search and identification - SciexOS, databases</li><li>Molecule Profiler, MarkerView</li><li>Summary and discussion</li></ul>

Thermo Scientific Orbitrap Exploris MX Mass Detector

Accelerate biopharmaceutical late-stage development, commercialization, manufacturing, and quality control (QC) by easily and reliably obtaining compliance-ready, high-quality mass information. 

<p><strong>Accelerate biopharmaceutical late-stage development, commercialization, manufacturing, and quality control (QC) by easily and reliably obtaining compliance-ready, high-quality mass information.&nbsp;</strong></p><p>The <strong>Thermo Scientific Orbitrap Exploris MX mass detector</strong> is the perfect fit for deploying routine mass monitoring.</p><p>In addition to high-resolution mass detection provided by Thermo Scientific Orbitrap mass analyzers, this fit for purpose system is simple to operate and compliance ready with <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/chromatography/chromatography-learning-center/chromeleon-cds-information/cds-mass-spectrometry-software.html">Thermo Scientific Chromeleon chromatography data system (CDS) software</a>. Consistent performance between the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/402">Thermo Scientific Orbitrap Exploris 240 mass spectrometer</a> and Orbitrap Exploris MX detector ensures seamless method transfer from development to QC.</p><h4><strong>High-resolution accurate-mass (HRAM) data provide utmost confidence for:</strong></h4><ul><li>Sequence confirmation</li><li>Peptide monitoring</li><li>Intact protein analysis (from small to large molecules, reduced mAbs, and intact mAbs under native and denaturing conditions)</li><li>Glycan profiling</li><li>Oligonucleotide and oligonucleotide impurity mass confirmation</li></ul><h3><strong>Highlights of Orbitrap Exploris MX mass detector&nbsp;</strong></h3><div colctrl-id="5-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h4><strong>Simplicity for scientists and technicians</strong></h4><p>Simplify tasks and reduce errors for more ‘right first time’ analyses with Chromeleon CDS, with built in methods, control, data processing, and management. The suite of smart tools makes your work faster and easier, while ensuring reproducible, high-quality mass monitoring.</p></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h4><strong>Accelerate productivity</strong></h4><p>High uptime boosts productivity. Rapid “set and forget” calibration procedures provide consistent mass stability for at least four weeks at prescribed conditions. Instrument status monitoring and optimized pressure control alert users when maintenance is needed, avoiding unnecessary downtime and repeat analyses.</p></div></div></div></div><div colctrl-id="6-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h4><strong>Compliance for competitive advantage</strong></h4><p>Designed for data integrity, data security, and compliance, fully scalable Chromeleon CDS provides comprehensive technical controls to give you a competitive edge in meeting global regulatory requirements.</p></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h4><strong>Consistent results deliver confidence</strong></h4><p>Robust and reliable performance from system to system and site to site ensure confidence in results used to make critical decisions. Industry-proven Orbitrap technology, now purposely designed for mass monitoring in future-proof lab operations.</p></div></div></div></div><div colctrl-id="7-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h4><strong>Seamless method transfer to MAM</strong></h4><p>Easy transfer of sophisticated Multi-Attribute Method (MAM) assays from development to manufacturing bridges the gap between development and QC.</p></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h4><strong>Dedicated, global support team</strong></h4><p>The dedicated, global Thermo Scientific MAM team maximizes your productivity and confidence with installation, training, and fast service and support. Standardized system performance evaluation test (SET) and installation qualification/operational qualification (IQ/OA) thoroughly assess system performance with comprehensive installation and post-maintenance acceptance criteria.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Orbitrap_Exploris_MX_Mass_Detector_4_2ad72d9b21.jpg" alt="Orbitrap Exploris MX mass stability: mass deviation relative to first observed mass in parts-per-million for 9 BSA tryptic peptides monitored over a period of 6 weeks using the new internal recalibration option. Each data point is an average of 19 individual injections." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Orbitrap_Exploris_MX_Mass_Detector_4_2ad72d9b21.jpg 184w," sizes="100vw" width="1240" height="1052"></p><h3><strong>Accelerate MAM deployment&nbsp;</strong></h3><h4><strong>Seamless knowledge and method transfer</strong></h4><p>Benefit from the end-to-end Thermo Scientific MAM 2.0 workflow approach to comprehensive characterization and monitoring of biotherapeutics from development to commercialization. <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/402">Orbitrap Exploris 240</a> mass spectrometer methods, established during development, seamlessly transfer to the Orbitrap Exploris MX detector in manufacturing or by contract partners. In addition to full integration into the high-resolution MAM 2.0 workflow, the usability and low cost of the Orbitrap Exploris MX detector make it the perfect fit for high-throughput QC and contract labs.</p><p>Users can identify and evaluate relevant product quality attributes (PQAs) via high-throughput analytics provided by Thermo Scientific BioPharma Finder software. Connected labs can access data from development through QC using MAM 2.0 powered by Thermo Scientific Ardia Platform. And, PQAs can be monitored throughout the entire drug development process using the MAM target peptide workbook built from the list of identified peptides upon incorporation into a Chromeleon processing method. The processing method along with the instrument method, injection sequence, view setting and report template can be stored into a MAM eWorkflow for easy and direct transfer to QC via Chromeleon CDS Enterprise software.</p><div><h5><strong>MAM 2.0 offers:</strong></h5><ul><li>Fast decision making based on high-confidence PQAs obtained using industry-leading HRAM Orbitrap technology</li><li>Seamless knowledge and method transfer across instruments, departments, and sites using compliance-ready, Chromeleon CDS enterprise software, and Ardia Platform</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Orbitrap_Exploris_MX_Mass_Detector_cd7474e7ed.jpg" alt="Thermo Scientific Orbitrap Exploris MX Mass Detector" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Orbitrap_Exploris_MX_Mass_Detector_cd7474e7ed.jpg 245w," sizes="100vw" width="1170" height="504"></p><blockquote><p><strong>Thermo Scientific MAM 2.0</strong></p><p>The end-to-end MAM solution for a fully connected, compliance-ready platform. MAM 2.0 includes everything you need to bring your next biotherapeutic candidate straight through to breakthrough.</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/pharma-biopharma/biopharmaceutical-analytical-testing/multi-attribute-method.html"><strong>Learn more</strong></a></li></ul></blockquote></div></div></div></div></div>

Thermo Scientific Orbitrap Exploris Mass Spectrometers

Discover which Orbitrap Exploris mass spectrometry system will meet your business needs for more efficient screening, identification, confirmation and quantitation.

<p><strong>Benefit from record-setting performance. With built-in intelligence, sensitivity and selectivity; the Thermo Scientific Orbitrap Exploris mass spectrometry is quantitative high-resolution, accurate-mass (HRAM) liquid chromatography mass spectrometry (LC-MS) for analysis depth to the lowest levels with high quantitative accuracy and precision to meet your exact analytical requirements. Scale up your research and translate your results more rapidly and simply than ever before.</strong></p><h3><strong>Why choose an Orbitrap Exploris mass spectrometer for your laboratory?</strong></h3><p>Discover which Orbitrap Exploris mass spectrometry system will meet your business needs for more efficient screening (including targeted, suspected and nontargeted), identification, confirmation and quantitation.</p><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1490"><strong>Orbitrap Exploris MX mass detector</strong></a></h4><p>Accelerate biopharmaceutical commercialization, manufacturing and quality control by easily and reliably obtaining compliance-ready, high-quality mass information with the Thermo Scientific Orbitrap Exploris MX Mass Detector.</p><p><strong>Typical applications: </strong>Biopharmaceutical characterization and QC, intact protein analysis, Multi-Attribute Method (MAM), oligonucleotides, pharmaceuticals</p><p><strong>Analyses: </strong>Targeted / non-targeted screening (MS), Unknown Identification (MS), Absolute and Relative Quantitation (MS)</p><p><strong>Resolution powers: </strong>180,000</p><p><strong>Mass range: </strong>m/z 40–3,000 up to m/z 8,000 with BioPharma option</p><p><strong>Scan speed: </strong>22Hz</p><p><strong>Sources &amp; Flexibility: </strong><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-exploris-mass-spectrometers.html#small">AP-SMALDI<sup>5</sup>&nbsp;AF source for MS Imaging</a></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Orbitrap_Exploris_MX_Mass_Detector_2_a84ed39672.jpg" alt="Thermo Scientific Orbitrap Exploris MX Mass Detector" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Orbitrap_Exploris_MX_Mass_Detector_2_a84ed39672.jpg 169w," sizes="100vw" width="1696" height="1575"></p><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/403"><strong>Orbitrap Exploris 120 Mass Spectrometer&nbsp;</strong></a></h4><p>Benefit from best in class high-resolution accurate mass for confident testing, screening and quantification of small molecules with the Thermo Scientific Orbitrap Exploris 120 Mass Spectrometer.&nbsp;&nbsp;</p><p><strong>Typical applications: </strong>Food and environmental testing, metabolomics, forensic toxicology, clinical research, pharmaceuticals</p><p><strong>Analyses: </strong>Targeted / non-targeted screening (MS), Unknown Identification (MS), Confirmation (MS/MS), Absolute and Relative Quantitation (MS and/or MS<sup>2</sup>)</p><p><strong>Resolution powers: </strong>120,000</p><p><strong>Mass range: </strong><i>m/z</i>&nbsp;40 – 3,000</p><p><strong>Scan speed: </strong>22Hz</p><p><strong>Sources &amp; Flexibility: </strong><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/order/catalog/product/IQLAAEGABBFAGOMZZZ">APCI/APPI Combination</a>, <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-exploris-mass-spectrometers.html#small">AP-SMALDI<sup>5</sup>&nbsp;AF source for MS Imaging</a></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Orbitrap_Exploris_120_Mass_Spectrometer_3_77e4e07555/Thermo-Orbitrap-Exploris-120-Mass-Spectrometer-3.jpg" alt="Thermo Scientific Orbitrap Exploris 120 Mass Spectrometer " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Orbitrap_Exploris_120_Mass_Spectrometer_3_77e4e07555/thumbnail_Thermo-Orbitrap-Exploris-120-Mass-Spectrometer-3.jpg 171w," sizes="100vw" width="938" height="856"></p><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/402"><strong>Orbitrap Exploris 240 Mass Spectrometer&nbsp;</strong></a></h4><p>Get unmatched confidence for discovery and identification, with application versatility and operational simplicity with the Thermo Scientific Orbitrap Exploris 240 Mass Spectrometer.&nbsp;</p><p><strong>Typical applications: </strong>Biopharmaceutical characterization, proteomics, metabolomics, lipidomics, food and environmental research, clinical research</p><p><strong>Analyses: </strong>Targeted / non-targeted screening (MS), Unknown Identification (MS), Confirmation (MS/MS), Absolute and Relative Quantitation (MS and/or MS<sup>2</sup>)</p><p><strong>Resolution powers: </strong>240,000</p><p><strong>Mass range: </strong><i>m/z</i>&nbsp;40 - 6000, (up to 8000 with BioPharma option)</p><p><strong>Scan speed: </strong>30Hz</p><p><strong>Sources &amp; Flexibility: </strong><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-accessories/field-asymmetric-ion-mobility-spectrometry-faims.html">FAIMS Pro Duo interface</a>, <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/order/catalog/product/IQLAAEGABBFAGOMZZZ">APCI/APPI Combination</a>, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2464">EASY-Spray Source</a>, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2463">Nanospray Flex Ion Sources</a>&nbsp;, <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-exploris-mass-spectrometers.html#small">AP-SMALDI<sup>5</sup>&nbsp;AF source for MS Imaging</a></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Orbitrap_Exploris_240_Mass_Spectrometer_2_a5085c34b0/Thermo-Orbitrap-Exploris-240-Mass-Spectrometer-2.jpg" alt="Thermo Scientific Orbitrap Exploris 240 Mass Spectrometer " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Orbitrap_Exploris_240_Mass_Spectrometer_2_a5085c34b0/thumbnail_Thermo-Orbitrap-Exploris-240-Mass-Spectrometer-2.jpg 175w," sizes="100vw" width="945" height="841"></p><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/401"><strong>Orbitrap Exploris 480 Mass Spectrometer&nbsp;</strong></a></h4><p>Achieve next-level insights, exploratory and targeted quantitation, next-gen power, performance, and ease of use with the Thermo Scientific Orbitrap Exploris 480 Mass Spectrometer.</p><p><strong>Typical applications: </strong>Shotgun proteomics (LFQ DIA, DDA), single cell proteomics, TMT multiplexing, targeted peptide quantification, metabolomics, biopharmaceutical applications (including HCP and protein characterization).</p><p><strong>Analyses: </strong>Targeted / non-targeted screening (MS), Unknown Identification (MS), Confirmation (MS/MS), Absolute and Relative Quantitation (MS and/or MS<sup>2</sup>)</p><p><strong>Resolution powers: </strong>480,000</p><p><strong>Mass range: </strong><i>m/z</i>&nbsp;40 - 6000, (up to 8000 with BioPharma option)</p><p><strong>Scan speed: </strong>40Hz</p><p><strong>Sources &amp; Flexibility: </strong><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/us/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-accessories/field-asymmetric-ion-mobility-spectrometry-faims.html">FAIMS Pro Duo interface</a>, <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/order/catalog/product/IQLAAEGABBFAGOMZZZ">APCI/APPI Combination</a>, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2464">EASY-Spray Source</a>, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2463">Nanospray Flex Ion Sources</a>&nbsp;, <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-exploris-mass-spectrometers.html#small">AP-SMALDI<sup>5</sup>&nbsp;AF source for MS Imaging</a></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Orbitrap_Exploris_480_Mass_Spectrometer_3_d9f3e43e8f/Thermo-Orbitrap-Exploris-480-Mass-Spectrometer-3.jpg" alt="Thermo Scientific Orbitrap Exploris 480 Mass Spectrometer " srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Orbitrap_Exploris_480_Mass_Spectrometer_3_d9f3e43e8f/thumbnail_Thermo-Orbitrap-Exploris-480-Mass-Spectrometer-3.jpg 239w," sizes="100vw" width="640" height="417"></p><h4><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/2304"><strong>Thermo Scientific Orbitrap Exploris EFOX Mass Detector</strong></a></h4><p><span>Simplify environmental and food safety testing with the Thermo Scientific™ Orbitrap Exploris™ EFOX Mass Detector, purpose-built for reliable high-resolution screening, quantitation and profiling of trace contaminants.</span></p><p><span><strong>Typical applications:</strong> Environmental testing, food safety testing, PFAS analysis, pesticide analysis, trace contaminant screening</span></p><p><span><strong>Analyses:</strong> Targeted / suspect screening (MS), Sample profiling (MS), Absolute and Relative Quantitation (MS)</span></p><p><span><strong>Resolution powers:</strong> 90,000</span></p><p><span><strong>Mass range:</strong></span> <i><span>m/z</span></i><span> 40–1,500</span></p><p><span><strong>Scan speed:</strong> 22 Hz</span></p><p><span><strong>Sources &amp; Flexibility:</strong></span> <span>OptaMax™ NG ion source, EASY-IC™ ion source for internal mass calibration, source-induced collision dissociation (CID), </span><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-exploris-mass-spectrometers.html#small">AP-SMALDI<sup>5</sup>&nbsp;AF source for MS Imaging</a></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Orbitrap_Exploris_EFOX_Mass_Detector_d619887924.jpg" alt="Thermo Scientific Orbitrap Exploris EFOX Mass Detector" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Orbitrap_Exploris_EFOX_Mass_Detector_d619887924.jpg 156w," sizes="100vw" width="650" height="650"></p>

Thermo Scientific Orbitrap Excedion Pro Mass Spectrometers

Welcome to the future of mass spectrometry. Enhance your research and achieve groundbreaking discoveries with Thermo Scientific Orbitrap Excedion Pro Hybrid Mass Spectrometers, the next generation of mass spectrometry.

Thermo Scientific Orbitrap Astral Zoom Mass Spectrometer

Orbitrap Astral Zoom boosts flexibility, speed, sensitivity, and quantitation for Omics and Biopharma with hybrid DIA, TMT HR modes, and next-gen acquisition.

Waters Xevo TQ Absolute XR Triple Quadrupole Mass Spectrometer

Quantitate with Absolute Power: up to 15× higher sensitivity, 6× longer uptime, and 50% less energy use. The Xevo TQ Absolute XR delivers eXtreme Robustness in a compact design.

<h4><strong>Quantitate with Absolute Power and eXtreme Robustness</strong></h4><p><strong>Gain absolute confidence to make powerful decisions and reach lower limits of quantitation, maintaining optimum sensitivity for longer, with the Xevo TQ Absolute XR instrument.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_Absolute_XR_cover_3ea1a92ace.jpg" alt="Waters: Xevo TQ Absolute XR Triple Quadrupole MS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_Absolute_XR_cover_3ea1a92ace.jpg 245w," sizes="100vw" width="1603" height="900"></p><p>Engineered for maximum productivity in a compact, sustainable design, the Waters Xevo TQ Absolute XR instrument features the new <strong>StepWave XR ion guide</strong> for enhanced resilience against contamination, even with high-throughput, complex sample matrices. That means more uptime, fewer interventions, and lab performance you can trust, all while aligning with your environmental, social, and governance (ESG) goals.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_Absolute_XR_Obr_2_Iontova_optika_Step_Wave_XR_doplnena_o_resolving_ion_guide_pro_ucinny_transport_iontu_ze_zdroje_do_MS_analyzatoru_02ce815972.jpg" alt="Waters: StepWave XR ion guide" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_Absolute_XR_Obr_2_Iontova_optika_Step_Wave_XR_doplnena_o_resolving_ion_guide_pro_ucinny_transport_iontu_ze_zdroje_do_MS_analyzatoru_02ce815972.jpg 245w," sizes="100vw" width="936" height="388"></p><h4><strong>Overview</strong></h4><ul><li><strong>Absolute confidence: </strong>Experience up to six times more robustness<sup>1</sup> with the new StepWave XR ion guide, designed for superior resilience to contamination. The Xevo TQ Absolute XR Mass Spectrometer ensures consistent, reliable performance, even under the most challenging analytical conditions.</li><li><strong>Absolute performance: </strong>Push quantitation limits further and meet stringent regulatory requirements with up to 15x greater sensitivity<sup>2</sup> for difficult-to-ionize negative mode compounds, setting a new benchmark in high-performance quantitation.</li><li><strong>Absolute efficiency: </strong>Reduce your laboratory’s environmental impact and operational costs with a mass spectrometer that consumes up to 50% less electricity and gas while generating 50% less heat than other high-performance TQ instruments.</li><li><strong>Absolute productivity: </strong>Streamline data analysis with waters_connect software, featuring Exception Focused Review (XFR) functionality to accelerate workflows, cutting data review time by up to 50% for more efficient, accurate results.</li><li><strong>Absolute versatility:</strong> Choose from our differentiated range of source options to find the technology most suited to your applications including DESI XS, APGC, and UniSpray.</li></ul><p><i><strong><sup>1</sup></strong>In a well-controlled experiment, performance was maintained for up to six times the duration on the Xevo TQ Absolute XR compared to the Xevo TQ Absolute; more than 12,000 samples of pesticides in fish feed matrix were analyzed</i></p><p><i><strong><sup>2</sup></strong>Compared to previous generation high performance tandem mass spectrometer, the Xevo TQ-XS.</i></p><ul><li><strong>Recommended Use: </strong>Reach lower limits of quantitation and meet regulatory requirements, even for challenging negative ionizing compounds.</li></ul><h5><strong>Ensure Absolute confidence with eXtreme Robustness</strong></h5><p>The Xevo TQ Absolute XR Mass Spectrometer analyzes up to six times more samples before service maintenance is required. Get the answer right first time and reduce unplanned downtime! This is one example of multiresidue pesticide analysis in a complex matrix (fish feed), for more examples please visit the brochure.</p><h5><strong>Accelerated Multiresidue Pesticides study</strong></h5><p>Fish feed, an example of a complex, challenging matrix, was tested using QuEChERS extraction without cleanup and without a divert-to-waste step. The Xevo TQ Absolute instrument demonstrated robust performance, operating effectively for approximately 1,500–2,000 injections (~3 months of continuous use1) before any signs of quadrupole charging appeared. The Xevo TQ Absolute XR mass spectrometer further extends this robustness, maintaining stable performance beyond 12,000 injections. Both instruments successfully handled over 400 MRMs in under 6 minutes, with no need for instrument venting for cleaning during the study.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_TQ_Absolute_XR_Triple_Quadrupole_MS_d5133acb55.jpg" alt="Waters: The Xevo TQ Absolute mass spectrometer began to show signs of quadrupole charging after approximately 1,500–2,000 injections of fish feed matrix (represented here by fluazinam; equivalent to ~3 months of use*). In contrast, the Xevo TQ Absolute XR system maintained system performance well beyond 12,000 injections." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_TQ_Absolute_XR_Triple_Quadrupole_MS_d5133acb55.jpg 234w," sizes="100vw" width="1280" height="853"></p><h5><strong>Achieve Absolute performance with improved sensitivity</strong></h5><p>To reach lower limits of quantitation and meet regulatory requirements, even for challenging negative ionizing compounds, you need an instrument that delivers absolute performance. The Xevo TQ Absolute XR instrument delivers up to 15x better sensitivity for challenging negative ionizing compounds than the previous product, so you can make confident decisions, faster.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_Xevo_TQ_Absolute_XR_instrument_delivers_up_to_15x_better_sensitivity_3535e8e6b1.jpg" alt="Waters: The Xevo TQ Absolute XR instrument delivers up to 15x better sensitivity for challenging negative ionizing compounds than the previous product, so you can make confident decisions, faster." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_Xevo_TQ_Absolute_XR_instrument_delivers_up_to_15x_better_sensitivity_3535e8e6b1.jpg 245w," sizes="100vw" width="1280" height="676"></p><h5><strong>Realize Absolute efficiency and lower operational costs</strong></h5><p>Many businesses are trying to actively address environmental sustainability while also reducing operational costs – and the Xevo TQ Absolute XR instrument helps make that possible.</p><p>With lower electricity consumption, gas consumption, and BTU/hr output, it lessens the demand for air conditioning and drives down energy costs. The minimized LC-MS/MS footprint of the Xevo TQ Absolute XR Mass Spectrometer delivers more analytical power per square foot, enabling lab managers to maximize space and drive greater operational efficiency.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_Xevo_TQ_Absolute_XR_instrument_offers_strong_performance_a26e9d6d7a.jpg" alt="Waters: The Xevo TQ Absolute XR instrument offers strong performance with less energy consumption in a compact form factor compared to today’s average high-end and high-end MS/MS systems, per data from published vendor site installation guides." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_Xevo_TQ_Absolute_XR_instrument_offers_strong_performance_a26e9d6d7a.jpg 245w," sizes="100vw" width="1280" height="622"></p><h5><strong>Achieve Absolute productivity with flexible software options</strong></h5><p>Unlock the full potential of the instrument when paired with our next-generation solution software. From automated data processing to the time-saving Exception Focused Review (XFR) feature, you’ll streamline data review time by up to 50% and spend more time advancing your science.</p><p>Built on a secure, traceable platform, waters_connect for Quantitation is built to accelerate your LC-MS/MS workflows. giving you the absolute confidence to scale, adapt, and lead in any environment.</p><p>For labs that need proven versatility across applications, the <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/635"><strong>Waters MassLynx Software</strong></a> continues to deliver time-tested flexibility and control.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_The_unique_functionality_of_waters_connect_96ac36ea2d.jpg" alt="Waters: The unique functionality of waters_connect for quantitation ensures your Xevo TQ Absolute XR provides absolute productivity." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_The_unique_functionality_of_waters_connect_96ac36ea2d.jpg 234w," sizes="100vw" width="1024" height="682"></p><h5><strong>Accelerating your success with award-winning service</strong></h5><p>Ensure your laboratory runs efficiently and is ready to address the opportunities of tomorrow with the Waters comprehensive analytical solutions with expert training (<strong>APS</strong>) and flexible and cost-effective solutions to advance your business with system service (<strong>FlexCHOICE</strong>), trade-ins and technological upgrades (<strong>FlexUP</strong>).</p><h5><strong>Cover more applications from our range of complementary technologies</strong></h5><p>Choose from our comprehensive range of ionization technologies providing differentiated application coverage to get the most from your analyses.</p><ul><li><strong>UniSpray</strong> - Absolute potential unlocked. Enable your lab to improve process efficiency through potential gains in sensitivity, precision and reduced matrix effects, relative to the equivalent electrospray ionization source option.3</li><li><strong>APGC </strong>- The next generation of GC is already here with Atmospheric Pressure Gas Chromatography offering labs absolute power - a powerful alternative to electron ionization technology, enabling low limits of detection, confident compound identification, and confirmation.</li><li><strong>DESI XS</strong> - With a combination of mass spectrometry imaging (MSI) and tandem quadrupole mass spectrometry, a remarkable technique emerges to perform sensitive, fast, and quantitative MSI directly on sample surfaces.&nbsp;</li></ul>

Waters Xevo CDMS charge detection mass spectrometer

Unlock direct mass measurement of megadalton biomolecules with Waters Xevo CDMS. Analyze viral vectors, RNA, and protein complexes with unprecedented precision and single-ion detection.

<p><strong>Understanding the mass and heterogeneity of large and complex biomolecules has long been a barrier to advancement. Conventional techniques fail to resolve the information needed to reconstruct the detailed nuance of structure, especially for megadalton molecular assemblies. It can take months or even years of tedious, expensive research to understand the basics of biomolecular structures.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_CDMS_charge_detection_mass_spectrometer_2_88ab59406f.jpg" alt="Waters: Xevo CDMS charge detection mass spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_CDMS_charge_detection_mass_spectrometer_2_88ab59406f.jpg 234w," sizes="100vw" width="1024" height="682"></p><p>Not anymore. With the breakthrough Xevo CDMS instrument, you can achieve precise measurement of challenging large and highly heterogeneous molecules—including viral vectors, virus-like particles (VLPs), RNA, and protein complexes—that were previously out of reach for mass characterization.</p><p>With this incredible innovation in charge detection mass spectrometry (CDMS), your lab can answer questions that were previously unaskable, unlocking the future of biological science, drug development, cell and gene therapy, and precision medicine.</p><h4><strong>Specifications</strong></h4><ul><li><strong>Technology:</strong> Charge detection mass spectrometry with single-ion detection</li><li><strong>Detection: </strong>Direct mass measurement powered by ELIT technology</li><li><strong>Mass Range: </strong>100 MDa and beyond with molecular weight characterization and purity determination of the​ largest, most heterogenous biotherapeutics</li><li><strong>Resolution: </strong>High-resolution MS analysis of complex mixtures</li><li><strong>Sample Types:</strong> Ideal for a variety of sample types including viral particles, protein assemblies, and exosomes</li><li><strong>Instrument Footprint: </strong>Modern benchtop design with revolutionary nanoESI source</li><li><strong>User Interface:</strong> Intuitive software with guided workflows</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_CDMS_The_ELIT_system_enables_ultra_sensitive_detection_by_isolating_and_measuring_individual_ions_a_capability_not_available_in_traditional_MS_systems_da8ddf4d65.jpg" alt="Waters: Xevo CDMS - The ELIT system enables ultra-sensitive detection by isolating and measuring individual ions—a capability not available in traditional MS systems." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_CDMS_The_ELIT_system_enables_ultra_sensitive_detection_by_isolating_and_measuring_individual_ions_a_capability_not_available_in_traditional_MS_systems_da8ddf4d65.jpg 234w," sizes="100vw" width="1024" height="682"></p><h4><strong>Overview</strong></h4><ul><li>Uncover hidden dimensions in biomolecular analysis across cell and gene therapy, biotherapeutics, biophysical science, and nanoparticle research</li><li>Investigate protein structure, function, and mechanisms of diseases at scale with measurement of massive, heterogeneous molecules that were previously invisible</li><li>Achieve real mass clarity with direct, unambiguous, single-ion mass measurement of highly complex, high-mass molecules</li><li>Gain powerful therapeutic insights with characterization of viral vectors, mRNA, and protein complexes</li><li>Get intuitive, ready to submit data workflows, and GxP-ready architecture</li></ul><p><strong>Recommended Use:</strong> For direct analysis of biomolecules in the megadalton range and beyond.</p><h4><strong>Expand biomolecular analysis beyond traditional tools with CDMS</strong></h4><p>Traditional characterization methods like SEC-MALS, analytical ultracentrifugation, and mass photometry often fall short for today’s biomolecules. They require large sample volumes, extended run times, or lack specificity. Xevo CDMS overcomes these limitations with direct, single-ion mass measurement across an extraordinary range, from below 1 MDa to beyond 100 MDa, using as little as 10 µL of sample. With streamlined workflows, faster results, and practical precision, Xevo CDMS delivers insights that conventional tools cannot match, making it a powerful complement or alternative in advanced biomolecular research.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Waters_Xevo_CDMS_charge_detection_mass_spectrometer_4_72564240d2.jpg" alt="Waters: Xevo CDMS charge detection mass spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Waters_Xevo_CDMS_charge_detection_mass_spectrometer_4_72564240d2.jpg 234w," sizes="100vw" width="1024" height="683"></p>

Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer

Triple quadrupole Thermo Scientific TSQ Certis built for long-term robustness, up to 900 SRMs/s, and stable performance across tens of thousands of injections using OptaMax Plus ion source and advanced Stellar ion optics.

<p><strong>The Thermo Scientific TSQ Certis is a high-performance triple quadrupole LC-MS/MS system designed for targeted quantitative analysis in demanding routine and regulated environments. Built on the proven </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/404"><strong>TSQ Altis Plus </strong></a><strong>platform, it integrates advanced front-end hardware, innovative ion optics, and compliance-ready software to deliver superior performance and uptime.</strong></p><p>Powered by the <strong>OptaMax Plus ion source</strong> and <strong>Stellar ion vector optics</strong>, TSQ Certis provides exceptional sensitivity, long-term robustness, and reproducible performance even for complex sample matrices. With an acquisition speed of up to <strong>900 SRMs per second</strong>, the system is ideally suited for <strong>pharmaceutical, clinical, forensic toxicology, environmental, and food safety laboratories</strong>.</p><p>Its rugged design supports <strong>tens of thousands of injections between cleanings</strong>, while an integrated <strong>early-warning maintenance system</strong> helps prevent unplanned downtime. Full compatibility with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Chromeleon CDS</strong></a><strong>, </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/77"><strong>TraceFinder</strong></a><strong>, </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1758"><strong>Xcalibur</strong></a><strong>, FreeStyle, and </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1764"><strong>mzCloud</strong> </a>ensures seamless integration into both routine and advanced analytical workflows.</p><h4><strong>Key features</strong></h4><ul><li>Triple quadrupole LC-MS/MS for targeted quantitation</li><li>Up to <strong>900 SRMs/s</strong> for high-throughput workflows</li><li>OptaMax Plus ion source with enhanced vaporizer temperatures</li><li>Excellent sensitivity and signal stability</li><li>Fast polarity switching <strong>&lt; 5 ms</strong></li><li>Rugged design with extended maintenance intervals</li><li>Compliance-ready software ecosystem</li><li><strong>3-year standard factory warranty</strong></li></ul><h4><strong>Selected specifications</strong></h4><ul><li><strong>Type:</strong> Triple Quadrupole LC-MS</li><li><strong>Mass range:</strong> 2–2010 m/z</li><li><strong>Resolution:</strong> 0.2 FWHM</li><li><strong>Acquisition speed:</strong> 900 SRMs/s</li><li><strong>Weight:</strong> 112 kg</li><li><strong>Dimensions (W × D × H):</strong> 833 × 660 × 703 mm</li><li><strong>LC compatibility:</strong> <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products?category=37&amp;search=vanquish">Vanquish LC</a>, Transcend LC</li><li><strong>Ion sources:</strong> OptaMax Plus, OptiSpray, EASY-Spray NG, FAIMS Pro Duo, VeriSpray</li></ul><div><div><div><div><div><h3><strong>Clinical research application: long-term instrument stability even with contaminant-heavy matrices</strong></h3></div></div><div><div><p>Analyzing human whole blood by LC-MS presents persistent challenges: matrix contaminants can accumulate within the ion source and API stack, compromising signal integrity and reproducibility. Restoring data quality demands time-consuming maintenance. The TSQ Certis Mass Spectrometer proves its durability by maintaining stable, precise performance through tens of thousands of injections—minimizing downtime and maximizing throughput.</p></div></div></div></div></div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_TSQ_Certis_Triple_Quadrupole_Mass_Spectrometer_0ec820459f.jpg" alt="Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer: Raw peak area of 15pg Ascomycin on column was determined in whole blood for 10,209 injections. The experiment was run over a 5-week period, and the system delivered an RSD of 13.8% with no cleaning of the ion transfer tube or the sweep cone." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_TSQ_Certis_Triple_Quadrupole_Mass_Spectrometer_0ec820459f.jpg 245w," sizes="100vw" width="2048" height="1152"></p><div><div><div><div><div><h3><strong>Endocrinology application: superior performance for steroid quantitation</strong></h3></div></div><div><div><p>Liquid chromatography coupled with triple quadrupole (LC–QqQ) mass spectrometry has become the industry standard for the quantitative determination of steroids in biological matrices. Compared to immunoassays, LC–QqQ MS offers superior analytical specificity, lower detection limits, and improved reproducibility, making it ideal for regulated pharmacokinetic, endocrinological, and clinical research applications. The TSQ Certis Mass Spectrometer provides the speed, specificity, and ultra-high sensitivity necessary for reliable steroid quantitation.&nbsp;</p></div></div></div></div></div><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_TSQ_Certis_Triple_Quadrupole_Mass_Spectrometer_2_3a48cc4deb.jpg" alt="Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer: LC SRM chromatogram of 18 steroids in BSA run using the Thermo Scientific Vanquish Flex UHPLC System and TSQ Certis Mass Spectrometer. This is an 8-minute chromatography run utilizing the Thermo Scientific Hypersil Gold C18 Column for separation. The samples were protein crashed from 0.05% BSA in PBS, and injecting 5µL." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_TSQ_Certis_Triple_Quadrupole_Mass_Spectrometer_2_3a48cc4deb.jpg 245w," sizes="100vw" width="2048" height="1152"></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_TSQ_Certis_Triple_Quadrupole_Mass_Spectrometer_3_62ede15e59.jpg" alt="Thermo Scientific TSQ Certis Triple Quadrupole Mass Spectrometer: Highly sensitive triple quadrupole instrumentation, often with advanced ion optics, is needed for Dihydrotestosterone (DHT) quantitation. The DHT quantitation peak and calibration curve of DHT run at 0.4pg on column with an RSD of 8.2%." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_TSQ_Certis_Triple_Quadrupole_Mass_Spectrometer_3_62ede15e59.jpg 245w," sizes="100vw" width="2048" height="1152"></p>

Wiley LC-MSⁿ Library of Drugs, Poisons and Their Metabolites, 2nd Edition

The Maurer/Wissenbach/Weber LC-MSⁿ Library, 2nd Ed., offers MS² and MS³ spectra for over 2,270 drugs and 3,600+ metabolites. It enables proven metabolite-based LC-MSⁿ screening and is one of the few libraries focused on metabolite spectra.

<h4><strong>Optimize LC-MSⁿ Screening with a Proven Metabolite-Based Library</strong></h4><p>The <strong>Maurer/Wissenbach/Weber LC-MSⁿ Library, 2nd Edition</strong>, offers a powerful screening method using <strong>MS² and MS³ spectra</strong> for over <strong>2,270 parent drugs</strong> and <strong>3,600+ metabolites</strong>. It’s one of the few libraries focused specifically on <strong>metabolite spectra</strong>, improving sensitivity, selectivity, and reducing false negatives in LC-MS analysis.</p><p>Developed for <strong>clinical and forensic applications</strong>, the library helps confirm compound identity and detect metabolites even when parent analytes are suppressed. It also reduces false positives through characteristic metabolite patterns.</p><p>Includes instrument-specific training materials on <strong>sample prep</strong>, <strong>chromatography</strong>, and <strong>MS settings</strong>.</p><h5><strong>Library Specs:</strong></h5><ul><li>Spectra: &gt;13,000</li><li>Structures: 10,787</li><li>Compounds: &gt;2,270</li><li>Metabolites/Artifacts: &gt;3,600</li><li>Endogenous Molecules: 90</li></ul><p>Search compound coverage at <a target="_blank" rel="noopener noreferrer" href="https://spectrabase.com/"><strong>compoundsearch.com</strong></a>.</p>

Wiley Registry of Tandem Mass Spectral Data – MSforID

The "Wiley Registry of Tandem Mass Spectral Data: MS for ID" consists of 12,048 positive and negative mode spectra of over 1,000 compounds of interest for forensics, toxicology, and pathology. 

<h4><strong>High Mass-Accuracy LC-MS/MS Library for Confident Identification</strong></h4><p>The <strong>Wiley Registry of Tandem Mass Spectral Data: MS for ID</strong> includes <strong>12,048 spectra</strong> in positive and negative modes covering <strong>1,163 compounds</strong> relevant to <strong>forensics, toxicology, and pathology</strong>—including drugs, pesticides, and pharmaceuticals.</p><p>Developed by the <strong>Oberacher team</strong> at Innsbruck Medical University under controlled conditions, the library offers <strong>~95% specificity</strong> and <strong>&gt;92% sensitivity</strong>. It delivers <strong>fast, reproducible results</strong> and is highly transferable across LC-MS/MS platforms.</p><p><strong>Highlights:</strong></p><ul><li>12,048 spectra for 1,000+ small bioorganic molecules</li><li>Optimized for high-accuracy identification</li><li>Includes advanced LC-MS/MS search algorithm</li><li>Compatible with most instrument formats</li></ul><p>Search compound coverage at: <a target="_blank" rel="noopener noreferrer" href="https://www.compoundsearch.com">www.compoundsearch.com</a></p>

Products focused on LC/MS/MS - page 2

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