<p><strong>Ion exchange (IEX) chromatography is an important separation technique that allows the separation of various ionizable molecules on the basis of the charge. With its unique combination of features, ion exchange chromatography stands out as an efficient chromatographic method because it:</strong></p><ul><li>Handles large sample volumes with ease.</li><li>Offers broad applications, particularly for enzymes and proteins.</li><li>Provides powerful resolving capabilities.</li><li>Supports automation for enhanced efficiency.</li><li>Features a simple scale-up mechanism.</li><li>Balances performance and affordability with moderate costs.</li></ul><h3><strong>Ion Exchange Chromatography’s Mechanism of Action</strong></h3><p>The core principle of ion exchange chromatography is based on the reversible exchange of ions between a mobile phase (the liquid solution containing the sample) and a stationary phase (the solid support with charged groups). The stationary phase can be either:</p><ul><li><strong>Cation Exchange:</strong> Contains negatively charged groups that attract and bind positively charged ions (cations).</li><li><strong>Anion Exchange:</strong> Contains positively charged groups that attract and bind negatively charged ions (anions).</li></ul><p>When a sample is introduced into the column, ions in the sample compete with counterions present on the stationary phase for binding sites. The strength of this interaction depends on several factors, including the charge density and size of the ions involved. Ions with higher charge densities typically bind more strongly to the stationary phase than those with lower charge densities.</p><p>This technique is used in various pharmaceutical industries due to its ability to separate various types of desired charged molecules. It is widely used for the purification of enzymes, amino acids, proteins, antibodies, simpler carbohydrates, organic compounds, and nucleic acids.</p><blockquote><p>Explore the <a target="_blank" rel="noopener noreferrer" href="https://www.phenomenex.com/techniques/hplc-ion-exchange"><strong>ion exchange technique</strong></a> to achieve effective separation in chromatography applications.</p></blockquote><h3><strong>Ion Exchange Methodology – How does it work?</strong></h3><p>The process of ion exchange chromatography can be broken down into several stages:</p><ul><li><strong>Equilibration:</strong> The column is equilibrated with a buffer solution that matches the pH required for optimal binding of the target analytes.</li><li><strong>Sample Loading:</strong> The sample is introduced into the column, where its charged components interact with the oppositely charged sites on the stationary phase. This interaction influences the extent to which each molecule is retained.</li><li><strong>Washing:</strong> A washing buffer is used to remove unbound or weakly bound impurities from the column.</li><li><strong>Elution:</strong> Bound molecules are eluted using a gradient of increasing salt concentration or by adjusting the pH, which alters the charge on the analytes and facilitates their release from the stationary phase.</li><li><strong>Collection and Analysis:</strong> Eluted fractions are collected and analyzed using various methods, such as UV spectroscopy or mass spectrometry, to identify and quantify the separated components.</li></ul><h3><strong>Applications of Ion Exchange Chromatography</strong></h3><ul><li><strong>Protein and Enzyme Purification:</strong> Widely used to isolate and purify proteins, enzymes, and other biomolecules based on their charge.</li><li><strong>Nucleic Acid Separation:</strong> Essential for separating and purifying DNA, RNA, and oligonucleotides.</li><li><strong>Amino Acid Analysis:</strong> Utilized for the analysis and quantification of amino acids in complex samples.</li><li><strong>Pharmaceutical Industry:</strong> Applied in drug formulation, quality control, and purification of biopharmaceuticals.</li><li><strong>Water Treatment:</strong> Used to remove unwanted ions, such as hardness-causing calcium and magnesium, from water.</li><li><strong>Food and Beverage Industry:</strong> Assists in purifying food additives, removing contaminants, and enhancing product quality.</li><li><strong>Metabolite Analysis:</strong> Facilitates the identification and separation of small charged metabolites.</li></ul><h3><strong>Key Advantages of Ion Exchange Chromatography</strong></h3><ul><li>One of the primary benefits is its ability to separate molecules based on their charge, which is a fundamental property of many biomolecules such as proteins, peptides, and nucleic acids.</li><li>Another significant advantage is its versatility. Ion exchange chromatography can operate under various conditions, including changes in pH, salt concentration, and temperature, allowing for the separation of a broad range of molecules. This flexibility enhances its applicability in different research fields, from pharmaceuticals to environmental analysis.</li><li>Additionally, ion exchange chromatography offers high resolution and reproducibility, ensuring that desired molecules are purified with excellent yield. The technique is also scalable, making it suitable for both small-scale laboratory work and large-scale industrial applications.</li></ul><h3><strong>Limitations of Ion Exchange Chromatography</strong></h3><ul><li>One significant limitation is its sensitivity to pH and ionic strength. The pH of the mobile phase must be carefully controlled, as changes in pH can affect the ionization state of both the analytes and the stationary phase, leading to incomplete separation or poor resolution. Similarly, the ionic strength of the elution buffer must be optimized; high salt concentrations are often necessary for eluting strongly bound analytes, which can be challenging for sensitive compounds that may precipitate or lose activity under such conditions.</li><li>Another limitation is the potential for sample degradation. High salt concentrations and extreme pH values required for elution can denature proteins or destabilize sensitive biomolecules. Additionally, the capacity of ion exchange columns is finite, meaning that the sample load must be carefully managed. Overloading the column can lead to poor separation and reduced resolution.</li><li>Ion exchange chromatography is also relatively time-consuming, as the elution process often involves gradual gradients of salt or pH, which can extend run times. Moreover, the technique is not suitable for all types of analytes, particularly non-ionic compounds or those that do not exhibit significant charge differences under the conditions used.</li></ul>

Principles of Ion Exchange Chromatography: A Comprehensive Guide

<h3><strong>What Gives Ginger Its Characteristic Kick?</strong></h3><p><strong>Fresh ginger is bright, aromatic, and sharply spicy, while dried or heated ginger develops a warmer and more intense character. Behind these sensory differences lies a group of bioactive compounds known as gingerols and shogaols. In this study, HPLC was used to compare their presence in fresh ginger, ginger tea, and several commercially available ginger shots.</strong></p><h4><strong>Gingerols and Shogaols: The Chemistry Behind Ginger</strong></h4><p>Ginger (<i>Zingiber officinale</i>) is widely valued both as a food ingredient and for its bioactive constituents. Among these, <strong>[6]-gingerol</strong> is the predominant and most extensively studied pungent compound in fresh ginger. Smaller amounts of <strong>[8]-gingerol</strong> and <strong>[10]-gingerol</strong> are also naturally present.</p><p>Processing changes this chemical profile. When ginger is heated or dried, gingerols can undergo dehydration and form a related group of compounds known as <strong>shogaols</strong>. One of these, <strong>[6]-shogaol</strong>, is associated with strong antioxidant activity and has also been investigated for its anti-inflammatory properties.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_1_Structure_of_6_gingerol_a737949416.png" alt="KNAUER: Figure 1: Structure of [6]-gingerol (drawn with MarvinSketch 6.0.1)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_1_Structure_of_6_gingerol_a737949416.png 245w," sizes="100vw" width="525" height="170"></p><h4><strong>Why Is Ginger So Popular?</strong></h4><p>Ginger is commonly associated with digestive support and is frequently used to help alleviate nausea, including motion sickness and mild gastrointestinal discomfort. Its constituents have also been studied in connection with inflammatory processes, muscle and joint discomfort, and broader physiological effects.</p><p>The chemical composition of ginger products, however, can vary considerably depending on the raw material, formulation, processing conditions, and extraction method. This makes instrumental analysis useful for examining what different ginger products actually contain.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Figure_2_Ginger_picture_generated_by_Open_AI_50c689581b.png" alt="KNAUER: Figure 2: Ginger picture generated with DALL-E (OpenAI; GPT-4o)" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Figure_2_Ginger_picture_generated_by_Open_AI_50c689581b.png 156w," sizes="100vw" width="454" height="454"></p><blockquote><p><i><strong>“And I had but one penny in the world, thou shouldst have it to buy gingerbread.”</strong></i><br><i>– William Shakespeare, Love’s Labour’s Lost</i></p></blockquote><h4><strong>Taking a Closer Look at I.N.G.W.E.R.</strong></h4><p>The study compared several commercial ginger shots with <strong>fresh ginger root and ginger tea</strong>.</p><p>The liquid ginger products were first centrifuged and the supernatant removed. The remaining solid material was extracted with <strong>methanol/water 50:50 (v/v)</strong> and centrifuged again. The resulting extract was passed through a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2380"><strong>0.22 µm nylon syringe filter</strong></a> before injection into the <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/products?category=39&amp;manufacturerItems=503"><strong>HPLC system</strong></a>.</p><p>Chromatographic separation was performed under reversed-phase conditions using a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1635"><strong>KNAUER Eurospher II C18H column</strong></a>:</p><ul><li>Column dimensions: <strong>150 × 3 mm</strong></li><li>Particle size: <strong>3 µm</strong></li><li>Order number: <strong>15CE185E2G</strong></li><li>Flow rate: <strong>0.8 mL/min</strong></li></ul><p>The gingerol concentration was <strong>not determined quantitatively</strong>. Instead, chromatographic signal heights were compared with those obtained from freshly extracted ginger root. Direct comparison between commercial products also needs to take into account that the individual shots contained different proportions of ginger.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Table_1_Percentage_of_ginger_in_shot_samples_according_to_their_list_of_ingredients_1a064c0399.jpg" alt="KNAUER: Table 1 Percentage of ginger in shot samples according to their list of ingredients" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Table_1_Percentage_of_ginger_in_shot_samples_according_to_their_list_of_ingredients_1a064c0399.jpg 210w," sizes="100vw" width="1107" height="820"></p><h4><strong>Ginger Content of the Tested Shots</strong></h4><h5><strong>Fresh Ginger and Ginger Tea</strong></h5><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Left_Chromatogram_of_fresh_ginger_root_4d6339e54d.jpg" alt="KNAUER: Left: Chromatogram of fresh ginger root, 5 g sample was extracted with MeOH:H₂O; 1 – [6]-gingerol,  2 – [8]-gingerol, 3 – [10]-gingerol. Right: Chromatogram of YogiTea ginger lemon, tea bag (1.8 g) was extracted with 200 ml hot water;  1 – [6]-gingerol" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Left_Chromatogram_of_fresh_ginger_root_4d6339e54d.jpg 245w," sizes="100vw" width="1537" height="485"></p><p>Fresh ginger provided the clearest representation of the characteristic gingerols. In contrast, only a small [6]-gingerol signal was observed in the tea extract. One important difference is that the tea was prepared using hot water rather than the methanol/water extraction applied to the other samples.</p><h5><strong>Classic and Pomegranate Ginger Shots</strong></h5><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Left_Chromatogram_of_classic_ginger_shot_b9de81bb02.jpg" alt="KNAUER: Left: Chromatogram of classic ginger shot, 1 -  [6]-gingerol, 2 - [8]-gingerol, 3 - [6]-shogaol,  4 - [10]-gingerol. Right: Chromatogram of  pomegranate ginger shot, 1 -  [6]-gingerol, 2 - [8]-gingerol, 3 - [6]-shogaol,  4 - [10]-gingerol" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Left_Chromatogram_of_classic_ginger_shot_b9de81bb02.jpg 245w," sizes="100vw" width="1522" height="475"></p><p>Both products showed a comparatively rich ginger-derived profile. In addition to <strong>[6]-gingerol</strong>, the chromatograms contained <strong>[8]-gingerol, [10]-gingerol, and [6]-shogaol</strong>.</p><p>Among the commercial products examined, the <strong>classic and pomegranate shots showed the strongest [6]-gingerol signals</strong>.</p><h5><strong>Turmeric and Fruit Shots</strong></h5><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Left_Chromatogram_of_Kurkuma_ginger_shot_b8887746f8.jpg" alt="KNAUER: Left: Chromatogram of Kurkuma ginger shot, 1 -  [6]-gingerol. Right: Chromatogram of  fruit shot, 1 -  [6]-gingerol" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Left_Chromatogram_of_Kurkuma_ginger_shot_b8887746f8.jpg 245w," sizes="100vw" width="1527" height="477"></p><p>In these two samples, <strong>[6]-gingerol</strong> was the principal ginger-related compound identified. The fruit shot produced the lowest [6]-gingerol signal of all the tested ginger shots, which is consistent with its comparatively low declared ginger content of <strong>2%</strong>.</p><h5><strong>Vitamin Acai and Pineapple Ginger Shots</strong></h5><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/KNAUER_Left_Chromatogram_of_Vitamin_Acai_shot_459cc69719.jpg" alt="KNAUER: Left: Chromatogram of Vitamin Acai shot, 1 -  [6]-gingerol,  2 - [8]-gingerol, 3 - [6]-shogaol,  4 - [10]-gingerol. Right: Chromatogram of  pineapple ginger shot, 1 -  [6]-gingerol, 2 - [8]-gingerol, 3 - [6]-shogaol,  4 - [10]-gingerol" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_KNAUER_Left_Chromatogram_of_Vitamin_Acai_shot_459cc69719.jpg 245w," sizes="100vw" width="1510" height="465"></p><p>The Vitamin Acai and pineapple products showed a broader profile similar to the classic and pomegranate shots. <strong>[6]-gingerol, [8]-gingerol, [10]-gingerol, and [6]-shogaol</strong> were detected in both samples.</p><h4><strong>What Did the HPLC Analysis Reveal?</strong></h4><p><strong>[6]-Gingerol was detected in every sample analyzed.</strong> The freshly extracted ginger root gave the strongest reference response, while among the commercial ginger shots, the classic and pomegranate variants showed the highest [6]-gingerol signals.</p><p>The <strong>fruit shot contained the lowest amount based on relative signal height</strong>, while the hot-water ginger tea extract produced only a small gingerol response.</p><p>A broader range of ginger-derived compounds was observed in the <strong>classic, pomegranate, pineapple, and Vitamin Acai shots</strong>, where [8]-gingerol, [10]-gingerol, and [6]-shogaol were detected alongside [6]-gingerol.</p><p>Because the experiment was designed as a comparative rather than quantitative analysis, the results should be interpreted as differences in chromatographic response rather than absolute gingerol concentrations. Nevertheless, the experiment demonstrates how straightforward reversed-phase HPLC can be used to compare the characteristic bioactive compounds present in fresh ginger and processed ginger products.</p><p>Whether fresh, brewed, or packed into a concentrated shot, ginger clearly offers more analytical complexity than its distinctive spicy taste might suggest.</p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/I_N_G_W_E_R_Analytica_254b7c26e3.pdf"><strong>Download application note I.N.G.W.E.R. – Instrumental Analysis of Nutritional Ginger Wellness Extracts here</strong></a></p></blockquote>

I.N.G.W.E.R. – Instrumental Analysis of Nutritional Ginger Wellness Extracts & Residues

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 14th September 2026? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies </strong>and <strong>Waters Corporation </strong>and posters by <strong>Shimadzu / AOAC </strong>and<strong> Thermo Fisher Scientific / Metabolomics!</strong></p><h3><strong>1. Agilent Technologies: Improved Analysis of Intact Proteins and Peptides by Reversed Phase HPLC Using the Altura Ultra Inert PLRP-S 1000 Å Column</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_altura_ultrainert_column_HPLC_analysis_5994_9322en_agilent_2b3a542647.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Intact protein analysis by reversed-phase HPLC (RP-LC) plays a vital role in quality control for determining the purity of biotherapeutic proteins and improving the identification and quantification of critical quality attributes (CQAs). When coupled to mass spectrometric detection, it allows several things. First, an accurate molecular weight to be determined; second, the identification of variants containing post‑translational modifications (PTMs) and proteoforms; and third, the antibody-to-drug ratio in the case of antibody drug conjugates (ADCs).<sup>1</sup>&nbsp;</p><p>While many RP columns have a silica-based stationary phase to enable broader functionalization, residual acidic silanol groups can interact with basic residues in peptides, proteins, and other biomolecules, resulting in significant peak tailing and loss of chromatographic performance. Polystyrene/divinyl benzene (PS/DVB)-based stationary phases do not contain unintentional adsorption sites. Additionally, larger pore sizes have demonstrated superior chromatographic efficiency through less diffusion restriction into the pore volume and reduction of size exclusion mechanisms, degrading the RP-based selectivity.<sup>2</sup>&nbsp;</p><p>Wide-pore columns like the PLRP-S 1000Å provide an exceptional performance with biomolecules, particularly when combined with MS-compatible mobile phase conditions such as formic acid.&nbsp;</p><p>Even so, some undesirable interactions may be observed when using stainless-steel column hardware. Molecules that possess multiple negative charges (including oligonucleotides, phosphorylated peptides and proteins, and proteins with low isoelectric point in general) may interact with exposed metal ions in stainless-steel column hardware. This can result in the need to "deactivate" new columns by making multiple injections of sample until reproducible results are obtained.&nbsp;</p><p>This application note demonstrates how the new <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=10&amp;search=Altura+Ultra+Inert"><strong>Altura Ultra Inert </strong></a>PLRP-S 1000 Å column serves as an effective high-performance workhorse in the analysis of large, intact biomolecules. Developed to effectively block nonspecific adsorption during separations, Ultra Inert technology reduced passivation time 15-fold and delivered ~ 10% greater recovery for mAbs and ADCs and up to 100% for smaller biomolecules like GLP-1s and small globular proteins.</p><h4><strong>Experimental</strong></h4><h5><strong>Instrumentation&nbsp;</strong></h5><ul><li>Agilent 1290 Multicolumn thermostat (G7116B)&nbsp;</li><li>Agilent 1290 Bio multisampler (G7137A)&nbsp;</li><li>Agilent 1290 Bio high-speed pump (G7132A)&nbsp;</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=10&amp;search=6530"><strong>Agilent 6530 Q-TOF MS system</strong></a>&nbsp;</li></ul><h5><strong>Software and data processing&nbsp;</strong></h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=10&amp;search=MassHunter+Workstation"><strong>Agilent MassHunter Workstation, version 10.1&nbsp;</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=10&amp;search=MassHunter+Qualitative+Analysis"><strong>Agilent MassHunter Qualitative Analysis software, version&nbsp;B.07&nbsp;</strong></a></li><li>Agilent DAR calculator, version B01.01</li></ul><h4><strong>Conclusion&nbsp;</strong></h4><p>Intact mass analysis is a critical methodology to determine the purity of biotherapeutics, but due to the chemical complexity of these analytes, nonspecific adsorption from both silica stationary phase and metal column housing can be highly deleterious to separation performance. The Agilent Altura PLRP-S 1000 Å provides a highly robust solution combining the chemical inertness of polystyrene/divinyl benzene stationary phase with the ultra‑inert Altura hardware to dramatically reduce deleterious peak tailing and increase recovery for biotherapeutics. Herein, we see that analyte recovery for both mAbs, ADCs, GLP-1s, and globular proteins are improved versus stainless-steel, while the Altura PLRP-S column is capable of monitoring both quality critical PTMs such as loss of drug payload as well as accurate quantification of ADC DAR.</p><h3><strong>2. Shimadzu / AOAC: Ambient Ionization Mass Spectrometric Detection of Aroma Released During Gummy Chewing</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/aoac_2026_47_2_34c41f762f.pdf"><strong>Full PDF for download</strong></a></li></ul><p>In recent years, there has been growing interest in evaluating flavor using analytical instrumentation, and retronasal aroma during eating is important. In this study, we proposed an analytical method for measuring retronasal aroma during eating using a single quadrupole mass spectrometer (<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=1&amp;search=2050"><strong>LCMS-2050</strong></a>) equipped with an ambient ion source (Dark Current Discharge Ionization : DCDI) without pretreatment.</p><h4><strong>Conclusion</strong></h4><p>We developed a simple method for evaluating retronasal aroma using a single quadrupole mass spectrometer with an ambient ionization source. Ambient ionization mass spectrometry (DCDI LCMS-2050) can rapidly measure retronasal aroma during eating. Time-resolved visualization reveals texture-dependent differences in aroma release dynamics among grape-flavored gummies. It is also expected to lead to the visualization of the marriage between food and alcohol. This approach may facilitate objective evaluation of flavor release during consumption and support product formulation and sensory science.</p><h3><strong>3. Thermo Fisher Scientific / Metabolomics: Orbitrap Tribrid Real-Time similarity searching of mzCloud library for guided unknown characterization of tea metabolites</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/po_004849_lsms_rtls_tribrid_apex_small_molecule_metabolomics_po004849_na_en_d0d3156065.pdf"><strong>Full PDF for download</strong></a></li></ul><p>In metabolomics LC-MS data is processed to generate a list of detected compounds with a level of confidence in the identity of each compound based on reference data. This reference data may be spectral data and/or retention time information stored in a library or in silico information generated based on fragmentation rules. These annotated compounds are then used to evaluate biological changes between normal and disease states. One of the major hurdles between collected data and coming to reliable conclusions about the biology is the limited number of standards available to build these libraries. It is common to have hundreds to thousands of compounds detected in a data set that have no library match because there is no commercial standard for that unknown. Instead, there is just an elemental formula and matches from a structure database. These structures can be compared using in silico fragmentation techniques to determine which isomers plausibly match the data. MSn data can help reduce the list of possible matches, but without guidance, ddMS3 may not consistently collect data on the most relevant MS2 fragments to accomplish this.&nbsp;</p><p>In this work we use Real-Time Library Search (RTLS) in a ddMS3 method to help guide the instrument in real time to collect the most relevant data for confirming structural matches.</p><h4><strong>Materials and methods</strong></h4><h5><strong>Test method(s)&nbsp;</strong></h5><p>1 μL aliquots were analyzed using a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/products?category=48&amp;manufacturerItems=3&amp;search=gold"><strong>Thermo Scientific Hypersil GOLD column</strong></a> on a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/744"><strong>Thermo Scientific Vanquish Horizon UHPLC</strong></a><strong> </strong>coupled with a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/561"><strong>Thermo Scientific Orbitrap IQ-X Tribrid mass spectrometer</strong></a> and <strong>Thermo Scientific Orbitrap Tribrid Apex Small Molecule mass spectrometer</strong>. RTLS was run in similarity mode using the offline version of <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1764"><strong>Thermo Scientific mzCloud library</strong></a>.&nbsp;</p><h5><strong>Data analysis&nbsp;</strong></h5><p>Data was processed using <strong>Thermo Scientific Freestyle and </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1759"><strong>Compound Discoverer software</strong></a><strong>.</strong></p><h4><strong>Conclusions&nbsp;</strong></h4><p>Tea extracts were analyzed using RTLS to find the most similar compound in the offline version of the mzCloud library and trigger MS3 on the highest m/z matching and non-matching fragments. This provided additional information to confirm similarity and provide insight on shared sub-structures to the library compound as well as additional information on the portions of the structure that were unique to the experimental compound.</p><h3><strong>4. Waters Corporation: The Quantification of Glucagon-like Peptide Receptor Agonists (GLP-1 RAs) in Plasma Extracts Using Capillary UHPLC-MS/MS</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/720009537_en_0068921516.pdf"><strong>Full PDF for download</strong></a></li></ul><div><div><section><div><div><div><div><div><div><h5><strong>Benefits&nbsp;</strong></h5><ul><li>10-fold improvement in sensitivity&nbsp;</li><li>Robust methodology for &gt;500 injections&nbsp;</li><li>Reduced solvent usage&nbsp;</li><li>No need for complex nanospray MS source</li></ul><p>Obesity represents, perhaps, the largest healthcare challenge, affecting approximately 1.3 billion people globally, contributing to a diverse range of chronic diseases e.g., metabolic, cardiovascular, muscular skeletal, and multiple cancers.1 The rapid growth of obesity and associated global healthcare costs means there is a critical need for safe effective treatments.2 GLP-1 RA initially developed for type 2 diabetes have shown clinical efficacy as weight loss medicines.2 These drugs mimic the action of gut hormones which regulate energy metabolism and appetite by interacting with the hypothalamus, brain stem etc., resulting in weight loss. The success of these GLP-1 RAs is associated with their on-target efficacy and long duration of action,3 e.g., half-life of semaglutide t½ = 160–180 hours3 cf. 1–2 minutes for human GLP-1.4 The long half-life of these GLP-1 RAs results in low, sub ng/mL plasma levels 48–72 hours after dosing, which requires a high sensitivity bioanalytical assay to accurately quantify the plasma concentrations5 and define the PK elimination phase.&nbsp;</p><p>Tandem quadrupole electrospray ionization (ESI) mass spectrometry, operated in multiple reaction monitoring (MRM) mode, coupled with 2.1 mm ID ultra-high performance liquid chromatography (UHPLC) is the dominant technology platform for quantitative bioanalysis. As next generation GIP/GLP-1 RAs promise to be more potent, resulting in lower dosing levels and plasma levels, there is a need for more sensitive analytical methodologies to support drug metabolism and pharmacokinetics (DMPK) studies. Capillary/nano LC-MS/MS have been extensively employed in proteomics to increase analytical sensitivity and enable small volume analysis.5 This sensitivity increase is derived from a combination of the superior ionization efficiency at low flow rates and analyte concentration due to the smaller column geometry.6 This application note illustrates the use of capillary (300 µm) UHPLC-MS/MS (MRM) to affect 10-fold improvement in GLP-1-RAs peak response in human plasma extracts, and detection limits as low as 20 pg/mL for tirzepatide.</p><h4><strong>Experimental</strong></h4><p>Capillary chromatography was performed on an <strong>ACQUITY™ M-class Chromatography System</strong> connected to a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/195"><strong>Xevo™ TQ-XS Mass Spectrometer</strong></a> (Waters Corporation, Wilmslow, UK) equipped with a microflow probe. Capillary UHPLC separations were performed on an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1952"><strong>ACQUITY Premier Peptide CSH C18</strong></a>, 300 Å, 1.7 µm, 300 µm x 50 mm Chromatography Column.</p><p>MS analysis was performed at unit mass resolution using positive ESI at a capillary voltage of 3.0 kV, with a cone voltage of 32 V. The cone gas flow, desolvation gas flow, and desolvation gas temperature were 50 L/h, 300 L/h and 600 °C, respectively. The data were analyzed using <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1544"><strong>waters_connect™ Software</strong></a><strong>,</strong> and MRM transitions used to monitored for the MS/MS detection of liraglutide, exenatide, semaglutide and tirzepatide were as follows: liraglutide 938.7 → 1128.4, exenatide 838 → 396, semaglutide 1029.2 → 1238.1, and tirzepatide 1204.2 → 396.2. Data analysis was performed using <strong>MS Quan Software.</strong></p><h4><strong>Conclusion</strong></h4><p>Bioanalysis plays a critical role in the drug discovery and development processes providing data to support DMPK, safety assessment, pharmacokinetics/pharmacodynamics (PK/PD), and clinical development studies. The development of new, more potent medicines, innovating delivery platforms, micro sampling, and new approach methodologies (e.g., organ on a chip) all require greater levels of analytical sensitivity. Capillary scale UHPLCMS/MS offers the potential to improve bioanalytical detection limits up to 10-fold, without the need for long analysis times and complex operation associated with nano spray LC-MS/MS. Here, the application of capillary (300 µm ID) scale chromatography for the detection of GLP-1 RAs in human plasma extracts at levels as low as 20 pg/mL with robustness over 500 injections was demonstrated.</p></div></div></div></div></div></div></section></div></div>

News from LabRulezLCMS Library - Week 38, 2026

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Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Phenomenex is a global technology leader committed to developing novel analytical chemistry solutions that solve the separation and purification challenges of researchers in industrial, government and academic laboratories.

Phenomenex

Based in Berlin, KNAUER is a medium-sized, owner-managed company that has been serving the sciences since 1962. We develop and manufacture scientific instruments of superior quality for liquid chromatography, including: Analytical HPLC/UHPLC, Preparative HPLC, Fast protein liquid chromatography (FPLC), Multi-column chromatography/Simulated moving bed (SMB) chromatography. High pressure dosing, in-line detection systems, and osmometry are additional business areas.

KNAUER

Thermo Scientific Vanquish Core HPLC System

The Vanquish Core HPLC systems provide exceptional analytical precision, detector sensitivity, and operational simplicity to enable unprecedented reliability and robustness.

Thermo Scientific™ Vanquish™ Neo UHPLC System

Take advantage of outstanding performance and productivity for all LC-MS workflows with nano-, capillary, and microflow using the Thermo Scientific™ Vanquish™ Neo UHPLC system.

Thermo Scientific Orbitrap Exploris 480 Mass Spectrometer

Empowering life science researchers to translate each experimental step to a new level of insight with built-in workflows and single-cell sensitivity.

<p><strong>Empowering life science researchers to translate each experimental step to a new level of insight with built-in workflows and single-cell sensitivity. Accelerate your path to impactful results with a next-generation ownership experience coupled with an intelligence-driven experimental approach. Achieve a new standard in performance to study trace samples with extraordinary accuracy, certainty, confidence and simplicity. You'll find market leading quantitative performance to solve your most complex challenges with ease, and the proven qualitative performance you expect from Orbitrap- based mass spectrometry.</strong></p><p>From exploratory to targeted quantitation, find the power and reliability to make large scale studies possible, while reducing everyday hassles as you increase productivity. And achieving it all, remarkably, within a compact footprint. An extraordinary instrument, providing extraordinary results; the Thermo Scientific Orbitrap Exploris 480 mass spectrometer.</p><h4><strong>Key benefits of the Orbitrap Exploris 480 mass spectrometer</strong></h4><h5><strong>Next-generation experience</strong></h5><p>Built with next-generation common hardware and software architecture, the guiding principle of ultimate performance and ease of use delivers effortless access to the value contained within your data.</p><h5><strong>High performance, high-throughput insights</strong></h5><p>Adding greater performance and intelligence to market-leading selectivity and spectral quality imparts productivity, depth, and certainty to small and large- scale studies.</p><h5><strong>Robust performance and exceptional serviceability increase uptime</strong></h5><p>By design, exceptional end-to-end robustness minimizes need for performance-related maintenance, increasing uptime and sample throughput.</p><h5><strong>Ease-of-use and intelligence to empower all users</strong></h5><p>Differences in user expertise can be a challenge in many laboratories. Workflows based on intelligent data acquisition methods leverage new levels of instrument performance to deliver high confidence, and high throughput.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Ion_path_and_key_components_of_the_Orbitrap_Exploris_480_mass_spectrometer_3f5791378c.webp" alt="Thermo Fisher Scientific: Ion path and key components of the Orbitrap Exploris 480 mass spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Ion_path_and_key_components_of_the_Orbitrap_Exploris_480_mass_spectrometer_3f5791378c.webp 245w," sizes="100vw" width="950" height="410"></p><div><h4><strong>How does the Orbitrap Exploris 480 MS enable greater data insights faster?</strong></h4></div><div><p>See what makes the Orbitrap Exploris 480 MS stand out, how it can empower all users to obtain the highest quality results and deepest insights with the least amount of effort; see how our breakthrough is now your breakthrough.</p></div><ul><li><strong>Next-Generation Instrument Design</strong></li><li><strong>Targeted Protein Quantitation Workflows with SureQuant IS</strong></li><li><strong>Advancing Accuracy, and Precision in Quantitative Proteomics through Multiplexing</strong></li><li><strong>Sub 1-ppm Mass Accuracy as Standard</strong></li><li><strong>Improved Performance through Instrument Enhancements</strong></li><li><strong>Intelligence-Driven Instrument Set-Up, Control and Data Acquisition</strong></li><li><strong>Visualize the Orbitrap Exploris Data Acquisition Modes</strong></li></ul><h4><strong>Optional features to maximize performance</strong></h4><p>Maximize performance and flexibility to expand experimental capabilities of the Orbitrap Exploris 480 mass spectrometer with multiple hardware and software options, allowing you to see more, quantify more, deliver more confidence and greater insights with even more productivity.</p><ul><li><strong>Enhance your Experimental Performance with the FAIMS Pro Duo interface</strong></li><li><strong>Comprehensive and confident biotherapeutic characterization</strong></li></ul><div data-uw-styling-context="true"><h4><strong>Data analysis made easy</strong></h4></div><div data-uw-styling-context="true"><p data-uw-styling-context="true">From complex proteomic challenges, quantitation with SureQuant and TMT multiplexing, through to complete biotherapeutic characterization, data analysis doesn’t have to be the bottleneck to accessing deeper insights into your high-quality MS data. Despite the numerous workflows involved in the analysis of proteins, there are flexible analysis tools which allow simple, yet confident, interpretation of your data to streamline your research and facilitate decision making to take your research to the next level.</p></div><ul><li><strong>Flexibly Identify and Quantify Proteins Based on your Workflow</strong></li><li><strong>The Right Path Towards Complete Biotherapeutic Characterization</strong></li><li><strong>Compliance and Enterprise Readiness with Chromeleon CDS Software</strong><br>&nbsp;</li></ul>

Thermo Scientific Orbitrap Exploris 240 Mass Spectrometer

Maximize performance and flexibility to expand your experimental capabilities, allowing you to discover more, see more, quantify more, and deliver more confidence and greater insights with even more productivity.

<div container-id="cq-colctrl-lt8" comp-id="B2"><div><p><strong>Maximize performance and flexibility to expand your experimental capabilities, allowing you to discover more, see more, quantify more, and deliver more confidence and greater insights with even more productivity.</strong></p><p>Deliver on your objectives with performance to drive discovery and identification, plus receive the quantitative precision and accuracy you need to confidently scale up and achieve impact. With operational simplicity through intelligent data acquisition and processing, discover your fast track to confident results regardless of sample complexity, the depth of insights required or the presence of unknown compounds.</p><h4><strong>Application capabilities through instrument versatility</strong></h4><p>Maximize performance and flexibility to expand your experimental capabilities, allowing you to discover more, see more, quantify more, and deliver more confidence and greater insights with even more productivity.</p><ul><li><strong>Confident and comprehensive proteomic analyses</strong></li><li><strong>Translational proteomics: Scaling translational discoveries into reliable clinical applications</strong></li><li><strong>Comprehensive biotherapeutic characterization: Maximize biotherapeutic insights&nbsp;</strong></li><li><strong>Intact native mass analysis: Maximize biotherapeutic insights&nbsp;</strong></li><li><strong>Metabolomics workflows: One solution for all metabolics workflows&nbsp;</strong></li><li><strong>Clinical research: Translate qualitative and quantitative assays into future clinical applications</strong></li><li><strong>Food/beverage and environmental analyses: Fast-track to results with confidence&nbsp;</strong></li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Thermo_Scientific_Orbitrap_Exploris_240_Mass_Spectrometer_a4d2d7771c.jpg" alt="Thermo Fisher Scientific: a) Quantitative experimental design for the analysis of a control and three knockout (KO) strains. b) The orthogonality of the FAIMS Pro interface shows improved peptide coverage when using a range of different CVs. c) Intensity ranking across five orders of quantitative dynamic range for the peptide spectrum matches provided by Proteome Discoverer software. d) Quantitative ratios for each of the samples, highlighting the relative abundance of the KO proteins." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Thermo_Scientific_Orbitrap_Exploris_240_Mass_Spectrometer_a4d2d7771c.jpg 245w," sizes="100vw" width="1000" height="543"></p><div><h4><strong>Key benefits of the Orbitrap Exploris 240 mass spectrometer</strong></h4></div><div><p>Delivering actionable insights faster than ever before by combining proven benefits of Thermo Scientific Orbitrap technology, with sub 1-ppm mass accuracy and high resolution, with intelligent data acquisition and processing.</p></div><h5><strong>Everyday experimental flexibility</strong></h5><p>Discover workhorse versatility from confident proteomic and small-molecule identification and quantitation to biopharmaceutical characterization and in-depth sample-profiling.</p><h5><strong>Faster path to confident insights</strong></h5><p>Delivering actionable insights faster than ever before by combining proven benefits of Thermo Scientific Orbitrap technology, such as sub 1-ppm mass accuracy and high resolution, with intelligent data acquisition and processing.</p><h5><strong>Reliable, robust, and maintainable</strong></h5><p>Meet an exceptional system every day, one with versatility and operational simplicity, but that doesn’t compromise robustness and reliability so you can be confident in its ability to perform on long-term studies.</p><h5><strong>Focus on driving results with faster setup</strong></h5><p>Fully integrated instrument control, setup, and data processing, helps you focus on delivering actionable results while single-system calibrations and pre-defined method templates drive productivity.</p><blockquote><h5><strong>Top reasons to choose Orbitrap Exploris 240 MS over Q-TOF instrumentation</strong></h5><p>Others claim to set new standards in proteomics. Is Protein ID without quantitation sufficient for shotgun proteomics to provide biological insights? Meet the Orbitrap Exploris 240 mass spectrometer – with leading quantitative performance, sensitivity and versatility, designed to meet your needs.</p><p>Trust us to deliver technology innovations that are foundations of reliable workflows and solutions, along with publishable and actionable results.</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/products-and-services/promotions/industrial/10-reasons-choose-orbitrap-exploris-over-qtof.html"><span><strong>Learn more</strong></span></a></li></ul></blockquote><h4><strong>Data Analysis with connectivity to drive productivity</strong></h4><p>From complex proteomic challenges, complete biotherapeutic characterization, or small-molecule discovery to everyday testing, data analysis is your gateway to accessing deeper insights into your high-quality MS and MS2 data. Despite the numerous workflows involved, there are flexible analysis tools for simple, confident interpretation of your data to streamline research and facilitate rapid decision making.</p><ul><li><strong>Flexibly identify and quantify proteins based on your workflow</strong></li><li><strong>Biopharmaceutical characterization with BioPharma Finder software</strong></li><li><strong>Streamline your small-molecule qualitative and quantitative assays</strong></li><li><strong>Small-molecule characterization with Compound Discoverer software</strong></li><li><strong>Complete screening and quantitation using Thermo Scientific TraceFinder software</strong></li><li><strong>Complete compliant control with Chromeleon CDS for MS</strong></li></ul></div></div>

Thermo Scientific Orbitrap Exploris 120 Mass Spectrometer

With its unique ability to provide consistently accurate data and a design made for operational simplicity, it sets the new standard in instrument productivity and ruggedness.

<p><strong>The proven Thermo Scientific Orbitrap technology in the Thermo Scientific Orbitrap Exploris 120 mass spectrometer accelerates your route to qualitative and quantitative confidence for both method development and everyday testing purposes. With its unique ability to provide consistently accurate data and a design made for operational simplicity, it sets the new standard in instrument productivity and ruggedness.</strong></p><h4><strong>Key benefits of the Orbitrap Exploris 120 mass spectrometer&nbsp;</strong></h4><h5><strong>Confidently perform high-throughput qualitative and quantitative analysis</strong></h5><p>Spend less time questioning your results with the unique ability of Orbitrap high-resolution, accurate-mass spectrometers (HRAM) to provide accurate results and reduce false positives or negatives. Confidently resolve ions of interest from interfering ions with high mass resolution up to 120,000 at m/z 200 for both method development and everyday testing analyses.</p><h5><strong>Keep your laboratory running seamlessly with the new standard in instrument ruggedness</strong></h5><p>Maximize return on your investment with capabilities that minimize downtime. Perform a single, stable calibration for the entire mass range from m/z 40-3000. With an improved scan rate up to 22 Hz, maximize your compound coverage with confidence. The ability to do both positive and negative mode switching ensures you analyze twice as many analytes in the same sample.</p><h5><strong>Focus on driving results with faster method set-up</strong></h5><p>Empower high-resolution MS users by giving them the ability to analyze samples using ready-to-run method templates. Minimize time spent on software training for Thermo Scientific MS users with a common software user interface for data acquisition.</p><h4><strong>How the Orbitrap Exploris 120 MS works</strong></h4><p>Discover how the Orbitrap Exploris 120 MS instrument enables you to prioritize your time on making critical decisions which impact the future of you or your client's organization. The latest instrument capabilities have been designed with the sole purpose of putting you on the fast path to accurate, reportable results. Leave the lab at the end of the day feeling productive and accomplished.</p><ul><li><strong>Uncover and quantify more suspect analytes</strong></li><li><strong>Sub-ppm mass accuracy as standard</strong></li><li><strong>System to system consistency</strong></li><li><strong>Robust performance</strong></li><li><strong>Maximize compound coverage with faster scan rates&nbsp;</strong></li><li><strong>Analyze samples twice as fast with rapid polarity switching&nbsp;</strong></li><li><strong>Intelligence-driven instrument setup, control and data acquisition&nbsp;</strong></li><li><strong>Quantitation: Which scan modes do I use on the instrument?</strong></li><li><strong>Take a video tour&nbsp;</strong></li></ul><div><h4><strong>Data analysis software: Streamline small molecule qualitative and quantitative assays</strong></h4></div><div><p>Connecting small molecule unknown identification and characterization through to screening and quantitation doesn’t just stop at data acquisition across multiple platforms. Now that you have acquired comprehensive, high-quality MS and MS<sup>2</sup> data, you need to identify and characterize unknowns and transfer discovery knowledge through to every day testing.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Which_data_analysis_software_is_right_for_you_30a173dd7f.jpg" alt="Thermo Fisher Scientific: Which data analysis software is right for you?" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Which_data_analysis_software_is_right_for_you_30a173dd7f.jpg 213w," sizes="100vw" width="1385" height="1016"></p><p>Our connected data processing software ecosystem streamlines interpretation of your high-confidence discovery data through powerful Thermo Scientific Compound Discoverer software with direct access to the world’s largest LC-MS<sup data-uw-styling-context="true">n</sup> reference spectral library, Thermo Scientific&nbsp;mzCloud, or through utilization of offline or proprietary libraries. These libraries act as your knowledge repository and allow direct transfer through to everyday screening and quantitation using Thermo Scientific&nbsp;TraceFinder software.</p><ul><li><strong>mzCloud Mass Spectral Library</strong></li><li><strong>Small molecule characterization with Compound Discoverer software</strong></li><li><strong>Complete screening and quantitation using TraceFinder software</strong></li><li><strong>Complete compliant control with Chromeleon CDS for MS</strong></li></ul><h4><strong>Common applications for Orbitrap Exploris 120 Mass Spectrometer</strong></h4><p>To perform method development and everyday testing with confidence, you need a liquid chromatography mass spectrometry (LC-MS) workflow solution that is relevant to your laboratory’s goals. The Orbitrap Exploris 120 MS instrument can be used for a variety of applications, including clinical research, environmental and food safety, forensic toxicology, and pharmaceutical analysis.</p><ul><li><strong>Clinical Research</strong></li><li><strong>Forensic Toxicology</strong></li><li><strong>Drug Screening and Confirmation</strong></li><li><strong>Environmental Emerging Contaminants</strong></li><li><strong>Pesticide Residues Analysis</strong></li><li><strong>Veterinary Drugs Residues Analysis</strong></li><li><strong>Pharmaceutical applications</strong></li></ul></div>

Thermo Scientific TSQ Altis Plus Triple Quadrupole Mass Spectrometer

Overcome quantitative workflow challenges with the TSQ Altis Plus MS, which ensures superior speed, sensitivity, and precision for low-level detection in complex matrices.

<p class="cke-user_style-important"><strong>Advance quantitative workflows and increase productivity</strong></p><p><strong>Address current and future challenges with Thermo Scientific TSQ Plus triple quadrupole mass spectrometers, which provide enhanced acquisition speed/sensitivity, proven robustness, and reliability. Instrument choices offer features for a range of applications, from everyday targeted quantitation to cutting-edge research.</strong></p><h2><strong>TSQ Altis Plus Triple Quadrupole Mass Spectrometer</strong></h2><h3><strong>Ultimate quantitative performance made possible</strong></h3><p>Overcome the most demanding quantitative workflow challenges. With superior <strong>acquisition speeds, enhanced sensitivity, prototypical selectivity</strong>, and <strong>exceptional robustness</strong>, the <strong>TSQ Altis Plus mass spectrometer </strong>delivers unprecedented accuracy and precision <strong>for low-level compound detection</strong> and <strong>quantitation in complex matrices </strong>that redefines ultimate instrument performance.</p><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Altis_Plus_Triple_Quadrupole_Mass_Spectrometer_3_dddb4870a2/Thermo-TSQ-Altis-Plus-Triple-Quadrupole-Mass-Spectrometer-3.jpg" alt="Thermo Scientific TSQ Altis Plus Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Altis_Plus_Triple_Quadrupole_Mass_Spectrometer_3_dddb4870a2/thumbnail_Thermo-TSQ-Altis-Plus-Triple-Quadrupole-Mass-Spectrometer-3.jpg 156w," sizes="100vw" width="650" height="650"></figure><div><h2><strong>Highlights</strong></h2></div><div colctrl-id="2-1"><div><div container-id="cq-colctrl-lt7" comp-id="A1"><div><h3 style="text-align:left;"><strong>Achieve the highest confidence in targeted compound detection and quantitation through leading sensitivity&nbsp;</strong></h3><p>Greater than <strong>6 orders</strong> of linear dynamic range with high selectivity. Enhanced acquisition speeds empower large-scale studies for translational workflow development or method optimization with effective dwell time settings as low as <strong>0.3 milliseconds — 5 millisecond</strong> polarity switching maximizes productivity in fewer experiments.</p><p>Where data confidence is required, the instrumental features on the TSQ Altis Plus triple quadrupole mass spectrometer drive high-performance targeted experiments for complex matrices.</p><div colctrl-id="3-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><h3><strong>High-throughput screening and quantitation</strong></h3><p>Innovations in the ion source, mass analyzer, active <strong>Q2 collision cell</strong>, and <strong>RF electronics </strong>offer high sensitivity, selectivity, and superior acquisition speeds/polarity switching times that are ideal with ultra-high performance liquid chromatography (UHPLC) separations. With scheduled SRM acquisition and<strong> 600 SRMs/second</strong>, <strong>1000’s of compounds</strong> can be screened or quantified per method. Fast data acquisition reaches the number of required data points for outstanding confidence at extremely low concentrations, in the most challenging matrices.</p></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h3><strong>Expanded experimental capabilities</strong></h3><p>Integrated workflow solutions centered on the TSQ Altis Plus mass spectrometer address regulated requirements targeting a growing list of diverse compounds. New UHPLC and ion chromatography (IC) systems maximize sample delivery and separation capabilities, maintaining the sensitivity to meet minimum residue limits without costly sample preparation or derivatization steps. <strong>Thermo Scientific Chromeleon Chromatographic Data System</strong> (CDS) software controls all experimental attributes in a regulated environment to further drive productivity.</p></div></div></div></div><div colctrl-id="4-1"><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><figure class="image"><img style="aspect-ratio:650/650;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_TSQ_Altis_Plus_Triple_Quadrupole_Mass_Spectrometer_4_bc3264af33/Thermo-TSQ-Altis-Plus-Triple-Quadrupole-Mass-Spectrometer-4.jpg" alt="Thermo Scientific TSQ Altis Plus Triple Quadrupole Mass Spectrometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_TSQ_Altis_Plus_Triple_Quadrupole_Mass_Spectrometer_4_bc3264af33/thumbnail_Thermo-TSQ-Altis-Plus-Triple-Quadrupole-Mass-Spectrometer-4.jpg 156w," sizes="100vw" width="650" height="650"></figure><h3><strong>Operational simplicity</strong></h3><p>Targeted research and routine applications demand fast and responsive instrument control software, with intuitive operations. Simplified calibration approach consolidates steps needed by the operator, combining an intelligent instrument check and calibration routine. <strong>Direct method transfer </strong>from the previous generation Thermo Scientific TSQ mass spectrometers can be performed for equal or better performance <strong>without optimization</strong>.</p><p>Experimental determination of dwell times assigned to each transition has been automated based on user-defined chromatographic peak width and the option of fixed cycle time or optimal number of data points per chromatographic peak.&nbsp;Prioritization settings allow further adjustments.</p></div></div></div><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><h3><strong>Database integration</strong></h3><p>Method development for targeted acquisition methods requires a prior knowledge of optimal product ions and energetics. Utilization of <strong>experimental libraries </strong>created from discovery experiments can by-pass the need for purified standards and lengthy optimization routines. The output from processed data in <strong>Thermo Scientific TraceFinder software</strong> can be directly imported into the instrument method editor, streamlining large-scale study creation.</p><p>Discovery experiments, however, may not contain all compounds targeted in a study. Integration with <strong>Thermo Scientific mzCloud databases</strong> enables selection of additional compounds from the most advanced mass spectral database to be added into existing experimental methods.</p></div></div></div></div></div></div></div></div>

Thermo Scientific™ Dionex™ Aquion™ Ion Chromatography (IC) System

Perform basic anion or cation analyses reliably with Dionex™ Aquion™ IC system bundles that include hardware, software, and consumables for easy ordering.

<h4><strong>Reliable, budget-friendly ion chromatography for routine anion and cation analysis</strong></h4><p>Simplify ion analysis in your laboratory with the <strong>Dionex™ Aquion™ IC system</strong>, a compact and easy-to-operate platform designed for routine applications in <strong>environmental, food safety, and academic labs</strong>. Ideal for budget-conscious operations, the Aquion system delivers dependable performance, quick startup, and low operating costs.</p><h3><strong>Key system features</strong></h3><ul><li><strong>Chemically inert PEEK flow path</strong></li><li><strong>Serial dual-piston pump</strong><ul><li>Flow rate: 0.01–5.0 mL/min</li><li>Pressure: up to 5000 psi</li></ul></li><li><strong>High-pressure pulse dampener</strong></li><li><strong>Electrically actuated, PEEK, 6-port Rheodyne injection valve</strong></li><li><strong>Conductivity detection with digital signal processing</strong><ul><li>Range: 0–15,000 μS</li><li>Temperature-controlled conductivity cell for signal stability</li></ul></li><li><strong>Support for electrolytic or chemical suppressors</strong></li><li><strong>Optional column heater</strong></li><li><strong>Built-in inline vacuum degasser</strong></li></ul><h3><strong>Benefits of electrolytic suppression</strong></h3><ul><li>Lower background conductivity and reduced detection limits</li><li>Faster system startup</li><li>Superior sensitivity for both anion and cation analysis</li><li>No need for manual regenerant preparation</li></ul><h3><strong>Optimized detection with conductivity</strong></h3><p>The Aquion system is optimized for conductivity detection using a <strong>thermostated high-performance cell</strong> that ensures stability against ambient temperature fluctuations. Digital signal control offers a wide dynamic range for simultaneous detection of analytes with varying concentrations.</p><h3><strong>Seamless control with Chromeleon™ CDS software</strong></h3><p>Included in every system bundle, <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS)</strong></a> software provides intuitive instrument control, automated workflows, and streamlined data handling:</p><ul><li><strong>eWorkflows</strong>: auto-load instrument conditions and processing templates</li><li><strong>Calibration Wizard</strong>: step-by-step guidance for method setup and quantification</li><li><strong>Wellness Trending</strong>: monitor system performance over time for predictive maintenance</li></ul><h3><strong>Anion and Cation System Bundles</strong></h3><p>Each bundle includes everything needed to get started:</p><h4><strong>Included in all system bundles:</strong></h4><ul><li>Dionex Aquion IC System with power cable</li><li>Dionex Aquion Analysis Kit (anion or cation specific)</li><li>Chromeleon SE software and license</li><li>3-year warranty (parts-only coverage in years 2 and 3)<br>→ Optional extended warranty available including labor and travel in years 2 and 3</li></ul><h4><strong>Anion Analysis Kit includes:</strong></h4><ul><li><strong>Dionex IonPac AG22 (4 × 50 mm) guard column</strong></li><li><strong>Dionex IonPac AS22 (4 × 250 mm) analytical column</strong></li><li><strong>Dionex AERS 500 Carbonate (4 mm) suppressor</strong></li><li><strong>Combined Seven Anion Standard II</strong><br><i>Note: Eluent concentrate must be ordered separately.</i></li></ul><h4><strong>Cation Analysis Kit includes:</strong></h4><ul><li><strong>Dionex IonPac CG12A (4 × 50 mm) guard column</strong></li><li><strong>Dionex IonPac CS12A (4 × 250 mm) analytical column</strong></li><li><strong>Dionex CDRS 600 (4 mm) suppressor</strong><br><i>Note: Eluent concentrate and standards must be ordered separately.</i></li></ul><h3><strong>Why choose Dionex Aquion?</strong></h3><ul><li>Proven IC platform with straightforward operation</li><li>Reliable results and stable performance</li><li>Full compatibility with standard and microbore column formats (2–5 mm)</li><li>Low cost of ownership with high-quality support and service</li><li>Ideal entry point for labs new to ion chromatography</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Dionex_Aquion_Iontovy_Chromatograf_2_8c661a76f1/Thermo-Dionex-Aquion-Iontovy-Chromatograf-2.jpg" alt="Thermo Scientific™ Dionex™ Aquion™ Ion Chromatography (IC) System" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Dionex_Aquion_Iontovy_Chromatograf_2_8c661a76f1/thumbnail_Thermo-Dionex-Aquion-Iontovy-Chromatograf-2.jpg 156w," sizes="100vw" width="650" height="650"></p>

Thermo Scientific Chromeleon CDS Mass Spectrometry Software

Chromeleon CDS unifies MS workflows with full compliance, remote access, and seamless control of Thermo Scientific MS instruments in a scalable, secure platform.

<div><div><p><strong>Consolidate your mass spectrometry (MS) laboratory with robust support for targeted quantitation and screening workflows in biopharma, environmental, and food safety sectors.</strong></p><p><strong>Connect instruments, users, and data</strong> in a centralized scalable server-based system, providing remote data access and central management of methods, templates, and reports.<strong> Full support</strong> for GMP compliance helps ensure data integrity, traceability, and verification throughout the data lifecycle. Native control of Thermo Scientific MS instruments, including <strong>single quadrupole, triple quadrupole </strong>and <strong>high-resolution accurate mass</strong> (HRAM), enables robust instrument operations.</p><p><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Thermo Scientific Chromeleon Chromatography Data System (CDS) Software </strong></a>combines with industry-leading Thermo Scientific MS instrumentation to deliver an&nbsp;outstanding solution for targeted MS<sup>n</sup> quantitation workflows.</p><h3><strong>Key Chromeleon features</strong></h3><div><div><div><h4><strong>Built for MS workflows</strong></h4><p>Chromeleon Software supports targeted quantitation and screening MS workflows by providing a comprehensive solution for data acquisition, processing, and reporting. See how the software facilitates advanced data analysis and integrates seamlessly with other software tools to enhance the efficiency and reliability of your MS workflows. Examples include:</p><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/pharma-biopharma/pre-clinical-and-clinical-drug-testing/small-molecule-bioanalysis-dmpk.html"><strong>Bioanalysis:</strong></a><strong> </strong>Take advantage of simultaneous MS data acquisition, automated system suitability testing, spectral library integration, and data exchange with <a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/digital-solutions/lab-informatics/lab-information-management-systems-lims/solutions/watson.html">Thermo Scientific Watson LIMS.</a></li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/pharma-biopharma/biopharmaceutical-analytical-testing/intact-protein-analysis-workflows.html"><strong>Intact proteins:</strong></a><strong>&nbsp;</strong>Achieve high-quality results with optimized algorithms for both isotopically resolved and unresolved data, MS<sub><sup>1</sup></sub> - MS<sub><sup>3</sup></sub> targeted library searching, and deliver high-throughput, accurate results.</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/pharma-biopharma/biopharmaceutical-analytical-testing/multi-attribute-method.html?erpType=Global_E1"><strong>Multi-Attribute Method (MAM):</strong></a><strong>&nbsp;</strong>Combine the flexibility of <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1837"><strong>Thermo Scientific BioPharma Finder Software</strong></a><strong> </strong>with compliance-ready Chromeleon Software to deliver a powerful MAM workflow.</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/food-beverage/food-analytical-testing/persistent-organic-pollutants-food.html"><strong>Dioxin, PCBs, and POPs analysis:</strong></a><strong>&nbsp;</strong>Use built-in advanced internal standard techniques for accurate quantitation in complex matrices and automate sequence creation, calculations and reporting.</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/environmental/environmental-contaminant-analysis/emerging-contaminants/pfas-testing.html"><strong>PFAS analysis:</strong></a><strong>&nbsp;</strong>Combine Chromeleon Software with <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1759"><strong>Thermo Scientific Compound Discoverer Software</strong></a> for compliant MS data acquisition, advanced discovery, identification, and targeted processing, and reporting.</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/food-beverage/food-analytical-testing/pesticide-residues-analysis.html"><strong>Pesticide analysis:</strong></a><strong>&nbsp;</strong>Utilize out-of-the-box workflows for fast and simple processing with tailored view settings, automated cross-confirmation, and adherence to SANTE guidelines.</li></ul><div><div><div><h4><strong>Single software solution</strong></h4><p>Increase <strong>productivity with a single software solution</strong> for your entire laboratory and eliminate the complexity of multiple data systems to <strong>simplify training, streamline workflows, and reduce manual processes</strong> across your lab.</p><p>Supporting a broad range of <strong>MS and chromatography techniques</strong> within one intuitive platform, the <strong>consistent user experience spans all analyses</strong>—regardless of deployment model—and includes <strong>complete coverage from instrument control to data acquisition, processing, and reporting</strong> for both front-end separation and MS detection.</p><div><div><div><h4><strong>Control and access from anywhere</strong></h4><p>Keep your operations running <strong>smoothly and securely</strong>, whether working in the lab or remotely. Deliver <strong>secure, remote access</strong> to instruments and data, making it easy to <strong>monitor runs, review results, and manage workflows from anywhere</strong>.</p><p><strong>Reduce IT overhead</strong> with streamlined system management using tools like the <strong>built-in updater</strong> to automate centralized rollout of maintenance packages, operating system updates, antivirus updates, among others, across the entire installation.</p><p>Help ensure <strong>data security</strong> with comprehensive <strong>system access control</strong>, auditing, and reporting using powerful querying capabilities facilitated by <strong>automated, centralized data storage</strong> with a <strong>secure relational database</strong>.</p><div><div><div><h4><strong>Built-in resilience and scalability</strong></h4><p>Achieve <strong>resilient, scalable performance</strong> across your laboratory operations. Designed for <strong>continuous uptime with zero data loss</strong>, the software features <strong>best-in-class automated network failure protection</strong> to keep your laboratory running and protect your data.</p><p>Its <strong>flexible architecture scales effortlessly</strong> from small, on-premise installations to large, multi-site deployments—on-premise, in the cloud, or virtual—without the need for reinstallation—while maintaining a <strong>consistent user experience</strong>.</p><p>Safeguard your data at every stage with <strong>robust network architecture and multi-layered security</strong>, eliminating single points of failure. With Chromeleon Software, your lab stays <strong>secure, connected, and ready to grow</strong>.</p><div><div><div><h4><strong>Enabling regulatory compliance</strong></h4><p>Chromeleon Software is designed from the ground up to help MS and chromatography labs <strong>simplify achieving, maintaining and demonstrating compliance</strong> to rigorous regulatory standards such as <strong>GxP, ISO, and 21 CFR Part 11</strong>. It provides <strong>powerful tools to help ensure data integrity</strong>, including <strong>extensive user access controls</strong>, <strong>comprehensive time-stamped audit trails</strong>, and <strong>result versioning capabilities</strong>. <strong>Electronic signatures and automated reporting</strong> enable efficient data review by exception, allowing for <strong>quick identification and resolution of discrepancies</strong>. These features work together to support laboratories in maintaining <strong>secure, traceable, and compliant workflows</strong>.</p></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) Software

Run your lab on an intuitive, user-friendly Chromatography Data System (CDS) that also scales from workstation to global deployment. 

<div><div container-id="cq-colctrl-lt1" comp-id="A1"><div><h2>End the compromise between lab efficiency and IT needs</h2></div></div><div container-id="cq-colctrl-lt1" comp-id="A2"><div><p><strong>Run your lab on an intuitive, user-friendly Chromatography Data System (CDS) that also scales from workstation to global deployment. Connecting people, instruments, and enterprise data management, Thermo Scientific Chromeleon CDS delivers productivity gains, data integrity, and full support of GMP compliance for chromatography, third party systems, including capillary electrophoresis, and Thermo Scientific mass spectrometry instruments.</strong></p><p>Built-in Chromeleon eWorkflow™ provides you with the means to go from injection to final results in just three mouse clicks. Chromeleon CDS provides data security, audit-trails documentation and simplified reviews, and is built around a relational database to provide comprehensive coverage of functionality to adhere to GMP and data integrity guidelines.&nbsp;</p><p>Its service-oriented architecture allows for the fastest performance by separating high-load tasks to run in individual processes on dedicated hardware. With significant advances in system architecture delivering faster processing, particularly for MS users, and enhanced network stability for large networks through balanced distribution of data management and domain administration loads, your lab can perform like never before.</p><p>Chromeleon Enterprise Software effectively scales to accommodate over<strong> 1000 instruments</strong> and seamlessly connects users worldwide within a tiered enterprise system.</p><p>And now with the<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/1821"><strong>Thermo Scientific Ardia Platform</strong></a><strong>&nbsp;</strong>connected software environment, you can super-charge your Chromeleon CDS with enhanced lab management tools and Ardia Server-side processing for even faster MS/MS data handling speeds.&nbsp;</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_Chromatography_Data_System_CDS_Software_9_7afc16ebb0.jpg" alt="Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) Software" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_Chromatography_Data_System_CDS_Software_9_7afc16ebb0.jpg 245w," sizes="100vw" width="2570" height="1086"></p><div><h3><strong>Key CDS features</strong></h3></div><div><p>A networked or enterprise CDS is vital for compliant, efficient and reliable operation. Streamline your workflows using software that was built with both the lab and IT in mind. Scale from a single workstation up to global, multi-site deployment with a solution designed for tracking, accountability, and QA/QC that is incredibly easy to use, with fewer mouse clicks.</p><p>Chromeleon CDS supports more than<strong> 500 chromatography instruments</strong>, including third-party capillary electrophoresis systems and Thermo Scientific single/triple quadrupole as well as high-resolution accurate-mass (HRAM) mass spectrometry instruments in a single data system.</p></div><div colctrl-id="5-1"><div><div container-id="cq-colctrl-lt3" comp-id="A1"><div><div data-seo-schema="" data-seo-element="description"><div><h4><strong>Workstation</strong></h4><p><strong>Instruments, intelligence, insight</strong></p><p>Chromeleon CDS delivers ease of use, comprehensive instrument control, automated data analysis and flexible reporting.</p><ul><li>Eliminate errors and simplify training using eWorkflow procedures&nbsp;</li><li>Achieve more "right-first-time" analyses using Smart Startup and Intelligent Run Control</li><li>Accelerate data processing, reviewing and reporting with dynamic updating and smart tools built in</li></ul></div></div><figure class="image"><img style="aspect-ratio:2682/600;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_Chromatography_Data_System_CDS_Software_2_45040ea7dd.jpg" alt="Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) Software: Workstation" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_Chromatography_Data_System_CDS_Software_2_45040ea7dd.jpg 245w," sizes="100vw" width="2682" height="600"></figure><div data-seo-schema="" data-seo-element="description"><div><h4><strong>Workstation Connect</strong></h4><p><strong>Security, sharing, support</strong></p><p>Convert multiple workstations to a small network to realize many benefits of enterprise without the effort or expense.</p><ul><li>Remote instrument control and data processing</li><li>Compliance and data integrity tools as standard</li><li>Improved sharing and security of data without need for a separate server</li><li>Access guaranteed support response times</li></ul><p><img style="aspect-ratio:2682/600;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_Chromatography_Data_System_CDS_Software_3_92167c8126.jpg" alt="Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) Software: Workstation Connect" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_Chromatography_Data_System_CDS_Software_3_92167c8126.jpg 245w," sizes="100vw" width="2682" height="600"></p></div></div><div data-seo-schema="" data-seo-element="description"><div><h4><strong>Enterprise</strong></h4><p><strong>Compliance, connectivity, confidence</strong></p><p>Support your scientific business and digital transformation goals from single laboratory to global, multi-site, cloud-based deployment.&nbsp;</p><ul><li>Manage instruments, procedures, and protocols in a single software</li><li>Connect multiple sites to a central data server with the same performance as a fully local operation</li><li>Integrate with other informatics solutions: LIMS, LES or ELN</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_Chromatography_Data_System_CDS_Software_4_16c82a693c.jpg" alt="Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) Software: Enterprise" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_Chromatography_Data_System_CDS_Software_4_16c82a693c.jpg 245w," sizes="100vw" width="2682" height="600"></p><div><h3><strong>Focus areas</strong></h3></div><div colctrl-id="6-1"><div><div container-id="cq-colctrl-lt4" comp-id="A1"><div><div data-seo-schema="" data-seo-element="description"><div><h4><strong>Built for the Lab</strong></h4><p><strong>Analyze without compromise</strong></p><ul><li>Meet compliance and productivity needs</li><li>Designed for chromatography, CE, and MS (including HRAM)</li><li>Customizable user interface</li><li>Amplified spreadsheet-based custom reporting engine</li><li>Achieve more “right-first-time” analyses</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_Chromatography_Data_System_CDS_Software_5_b25345a248.jpg" alt="Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) Software: Built for the Lab" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_Chromatography_Data_System_CDS_Software_5_b25345a248.jpg 245w," sizes="100vw" width="2682" height="600"></p></div></div><div data-seo-schema="" data-seo-element="description"><div><h4><strong>Built for IT</strong></h4><p><strong>Standardize without compromise</strong></p><ul><li>Meet stability and data security needs</li><li>Ensure business continuity</li><li>Go beyond 1000+ connected users/instruments/workstations without affecting performance</li><li>Benefit from centralized management</li><li>Deliver strong, reliable ROI</li><li>Ability to adapt to your infrastructure</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_Chromatography_Data_System_CDS_Software_6_253bc4812c.jpg" alt="Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) SoftwareBuilt for IT" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_Chromatography_Data_System_CDS_Software_6_253bc4812c.jpg 245w," sizes="100vw" width="2682" height="600"></p></div></div><div data-seo-schema="" data-seo-element="description"><div><h4><strong>Built for Compliance</strong></h4><p><strong>Optimize without compromise</strong></p><ul><li>Utilize built-in features to establish and maintain your validated state&nbsp;</li><li>Schedule automated data management tasks</li><li>Simplify meeting latest regulatory requirements</li><li>Streamline with centralized data and audit trail review</li><li>Benefit from our rigorous testing</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_Chromatography_Data_System_CDS_Software_7_40b07fccc8.jpg" alt="Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) Software: Built for Compliance" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_Chromatography_Data_System_CDS_Software_7_40b07fccc8.jpg 245w," sizes="100vw" width="2682" height="600"></p></div></div><div data-seo-schema="" data-seo-element="description"><div><h4><strong>Built for MS</strong></h4><p><strong>Specialize without compromise</strong></p><ul><li>Leverage MS productivity tools for up to 10x faster processing</li><li>Optimize background processing whilst freeing the UI</li><li>Utilize built-in MS workflow packages and report templates</li><li>Gain confidence in results with support for cross-technique confirmation</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Chromeleon_Chromatography_Data_System_CDS_Software_8_94a5adf2cb.jpg" alt="Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) Software: Built for MS" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Chromeleon_Chromatography_Data_System_CDS_Software_8_94a5adf2cb.jpg 245w," sizes="100vw" width="2682" height="600"></p></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Thermo Scientific™ TraceFinder™ Software

Driven by a powerful and intuitive set of acquisition and data processing tools, Thermo Scientific TraceFinder software provides rapid access to your results and increases output across the entire laboratory.

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