<p><strong>Whether a drug can effectively bind to its target protein, or how different parts of a virus or a cell interact, depends on processes taking place at the level of individual molecules. Their behaviour is determined not only by their shape, but also by the electrostatic forces acting between them. Understanding how these forces are distributed helps scientists explain why certain molecules attract each other, how they bind and how they interact.</strong></p><p>This is where the <a target="_blank" rel="noopener noreferrer" href="https://acc.biodata.ceitec.cz/"><i><strong>Atomic Charge Calculator (ACC)</strong></i></a> comes in. Researchers at Masaryk University have been developing this computational tool for more than a decade. Its third and most advanced generation to date was developed at <strong>CEITEC Masaryk University</strong> and the<strong> Faculty of Science at Masaryk University</strong>, in collaboration with the <strong>Faculty of Informatics at Masaryk University</strong> and <strong>Palacký University Olomouc</strong>.</p><p><strong>ACC III </strong>calculates the electric charges of individual atoms and visualises their distribution directly within three-dimensional molecular structures. It brings together <strong>twenty different calculation methods</strong> in a single environment and can work with a wide range of molecules – from small organic compounds to proteins and other large biomolecular structures.</p><p>A key advantage of <strong>Atomic Charge Calculator III</strong> is that it combines a broad range of computational methods with ease of access. Basic calculations can be performed directly in a web browser, <strong>with no need to install specialised software or register for an account</strong>. The resulting charges can be displayed directly on a 3D model of the molecule. For advanced users and large-scale analyses, the platform also supports automated data processing and allows its computational core to be run locally.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Co_pritahuje_molekuly_Nova_generace_nastroje_z_CEITEC_zviditelnuje_sily_mezi_atomy_d32d7bd2cd.jpg" alt="CEITEC/Biological Data Management and Analysis Core Facility: What Attracts Molecules? A New Generation of a CEITEC Tool Makes the Forces Between Atoms Visible: Oseltamivir bound to influenza virus neuraminidase (blue: positive partial charges, red: negative charges). A strong electrostatic interaction occurs between a negatively charged region of the drug and positively charged regions of the protein." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Co_pritahuje_molekuly_Nova_generace_nastroje_z_CEITEC_zviditelnuje_sily_mezi_atomy_d32d7bd2cd.jpg 140w," sizes="100vw" width="1600" height="1786"></p><h3><strong>Why are scientists interested in the electric charges of atoms?</strong></h3><p>Electrons are not distributed evenly within molecules. Individual atoms can therefore carry different partial electric charges. These charges play an important role in determining how molecules behave towards their surroundings and towards one another.</p><p>Positively and negatively charged regions of molecules can attract each other, while regions with the same charge repel each other. The distribution of these charges therefore helps determine which molecules approach each other, how they orient themselves and how strongly they may bind. In biology, this is important, for example, in molecular recognition or when a drug binds to its target protein. Understanding partial charges therefore helps scientists gain insight into the interactions underlying the behaviour of many molecular systems.</p><p>There is, however, no single universal way to determine partial charges. Different computational methods can produce different values, and the choice of method also depends on how the results will be used. Accurate quantum-chemical calculations can also become very computationally demanding when large numbers of structures are involved. ACC III therefore brings together<strong> empirical methods </strong>that allow these calculations to be performed more quickly and on a large scale.</p><p><i>“From the outset, we designed ACC III to make calculating partial atomic charges as straightforward as possible. Users do not need to install anything or deal with complicated settings – they simply upload a molecule and start the calculation with a single click. The application then suggests suitable methods from the twenty available and can handle both small molecules and large biomolecular structures,”</i> says <a target="_blank" rel="noopener noreferrer" href="https://www.ceitec.eu/tomas-racek-ph-d/u94476?page=publication"><strong>Tomáš Raček</strong></a>, who has been developing and maintaining ACC since 2018.</p><h3><strong>How an antiviral drug binds to an influenza virus protein</strong></h3><p>The authors demonstrate what charge distribution can reveal using the well-known antiviral drug oseltamivir, marketed as Tamiflu. The drug binds to neuraminidase, a protein of the influenza A virus. ACC III can show directly within the three-dimensional structure where positive and negative partial charges are located and how they contribute to the interaction between the drug and the protein.</p><p><i>“The example of oseltamivir clearly shows why it is useful not only to calculate the charges, but also to visualise them directly within the structure. This allows us to see which parts of the two molecules interact electrostatically. The same approach can be used to study many other molecular systems,”</i> explains Tomáš Raček.</p><p><strong>ACC III is not limited to small molecules</strong>. It can also work with proteins and other large biomolecular structures. The authors demonstrate this using a second example: the <strong>SARS-CoV-2 </strong>pore complex. Coronaviruses form these pores during replication in infected cells and use them to transport viral RNA across membranes. Visualising partial charges helps distinguish the parts of the complex that pass through the non-polar environment of the membrane from its more highly charged regions.</p><h3><strong>From calculation straight to a 3D model</strong></h3><p>The new generation of the Atomic Charge Calculator also offers<strong> more advanced visualisation</strong>. It uses Mol*, which allows calculated charges to be mapped directly onto a three-dimensional structure and explored interactively. A visualisation created using ACC III was also selected for the<strong> cover of the special </strong><i><strong>Nucleic Acids Research</strong></i><strong> Web Server Issue</strong>. Created by Tomáš Raček, the cover image shows the distribution of partial charges in a membrane protein system.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/CEITEC_Co_pritahuje_molekuly_Nova_generace_nastroje_z_CEITEC_zviditelnuje_sily_mezi_atomy_3_85cc310925.jpeg" alt="CEITEC/Oxford University Press: What Attracts Molecules? A New Generation of a CEITEC Tool Makes the Forces Between Atoms Visible: Cover page in Nucleic Acids Research journal." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_CEITEC_Co_pritahuje_molekuly_Nova_generace_nastroje_z_CEITEC_zviditelnuje_sily_mezi_atomy_3_85cc310925.jpeg 124w," sizes="100vw" width="1600" height="2011"></p><p>Results can be downloaded in several standard formats and, for the first time, stored directly in the mmCIF format commonly used for three-dimensional biomolecular structures. Information about the structure and its calculated charges can therefore remain together in a single file and be used by other tools.</p><p>For researchers who need to process large numbers of structures, ACC III also provides an API and a computational core that can be run locally. The platform can therefore be used both for individual calculations through its web interface and as part of larger automated analyses.</p><h3><strong>More than a decade of development</strong></h3><p>Scientists introduced the first Atomic Charge Calculator in <strong>2015</strong>, followed by its second generation in <strong>2020</strong>. In the meantime, the team also developed specialised tools: PDBCharges for structures from the Protein Data Bank and AlphaCharges for structures from the AlphaFold Database.</p><p><i>“The Atomic Charge Calculator was never a one-off project,”</i> says <a target="_blank" rel="noopener noreferrer" href="https://www.ceitec.eu/prof-radka-svobodova-ph-d/u17518?page=publication"><strong>Radka Svobodová</strong></a>, Head of the Biological Data Management and Analysis Core Facility at CEITEC Masaryk University. <i>“For more than a decade, we have been continuously developing tools that respond both to new possibilities in structural bioinformatics and to the needs of their users. The third generation combines straightforward web-based use with capabilities that are important for the automated processing of large numbers of molecular structures.”</i></p><blockquote><p><strong>Atomic Charge Calculator III is freely available through its web interface and does not require registration for basic use.</strong> Its development was supported by the<strong> ELIXIR CZ </strong>research infrastructure.</p></blockquote><h5><strong>The authors presented the new generation of the tool in </strong><a target="_blank" rel="noopener noreferrer" href="https://academic.oup.com/nar/article/54/W1/W211/8662890"><i><strong>Nucleic Acids Research</strong></i></a><strong>.</strong></h5>

What Attracts Molecules? A New Generation of a CEITEC Tool Makes the Forces Between Atoms Visible 

<p><span><strong>Not every concentration job can tolerate heat — and not every concentrator that handles heat well can handle cold. </strong></span><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2441"><span><strong>Refrigerated centrifugal vacuum concentrators</strong></span></a><span><strong> exist for a specific reason: proteins, RNA, enzymes, and synthetic peptides degrade quickly under thermal stress, and standard concentrators that rely on heat alone can compromise sample integrity before evaporation finishes. We compared two of the leading refrigerated systems — the Labconco Refrigerated CentriVap and the </strong></span><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/2611"><span><strong>Thermo Fisher Refrigerated SpeedVac SRF110</strong></span></a><span><strong> — to see how they stack up for labs where sample preservation is non-negotiable.</strong></span></p><blockquote><p><a target="_blank" rel="noopener noreferrer" href="https://explore.organomation.com/labconco-refrigerated-centrivap-vs-thermo-fisher-refrigerated-speedvac"><span><strong>Download the full comparison with pricing here!</strong></span></a></p></blockquote><h3><strong>The Problem Refrigeration Actually Solves</strong></h3><p>It's a detail that gets lost in most spec-sheet comparisons: running a<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/products?manufacturerItems=540&amp;search=centrivap"><strong> vacuum concentrator </strong></a>without temperature control can cause a sample to over-cool itself. As solvent evaporates under vacuum, the process pulls latent heat from the sample — the same evaporative cooling effect that makes sweat feel cold on skin. For a heat-stable solvent, that's irrelevant. For a temperature-sensitive biomolecule, it can drop the sample low enough to risk unwanted freezing or sublimation mid-run. Labconco's own engineering notes for the Refrigerated CentriVap describe this directly: the unit pairs a refrigeration system with a heater so operators can hold a precise set-point temperature and avoid sublimated samples caused by evaporative cooling. That's the whole reason this product category exists, and it's worth understanding before comparing specs line by line.</p><h3><strong>Price: A Wider Gap at the High End</strong></h3><p>The <strong>Labconco Refrigerated CentriVap</strong> is typically priced around <strong>$13,000 USD</strong>. The <strong>Thermo Fisher SRF110</strong> runs higher, generally<strong> $15,000–$17,000 USD</strong>, and that's before factoring in the modular kit components — Thermo Fisher sells the SRF110 with a separate vacuum system, rotor, vapor trap, and heat transfer fluid bundled into the total kit price. The price gap between these two refrigerated units is proportionally larger than what we found comparing their non-refrigerated counterparts, which makes the value case for the CentriVap even more pronounced at this tier.</p><h3><strong>Capacity: The Difference That Matters Most Right Now</strong></h3><p>This is where the two systems really separate, and it lines up with where lab demand is heading. The Refrigerated CentriVap processes up to <strong>312 samples</strong> per run; the SRF110 tops out at <strong>132</strong>. Both handle volumes up to 50 mL, so this isn't a volume trade-off the way it was in our earlier comparison — it's a straight throughput advantage for the CentriVap.</p><p>That gap matters because<a target="_blank" rel="noopener noreferrer" href="https://peptidestaff.com/industry-trends/peptide-therapy-market-forecast-2026/"><strong> peptide-based therapeutics </strong></a>have become one of the fastest-growing classes of drugs in the pharmaceutical industry, and manufacturing capacity — not demand — is widely cited as the primary bottleneck holding the sector back. <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/article/7541"><strong>GLP-1 programs</strong></a> in particular are pushing <a target="_blank" rel="noopener noreferrer" href="https://www.bachem.com/knowledge-center/glp-1-demand-for-peptide-manufacturers/"><span><strong>peptide manufacturers</strong></span></a><span> </span>toward industrialized, large-scale production platforms rather than one-off batch work. <a target="_blank" rel="noopener noreferrer" href="https://www.organomation.com/"><strong>Sample prep equipment</strong></a> sits squarely inside that bottleneck: every purification run, HPLC fraction, and concentration step has to scale alongside the chemistry. A concentrator that processes more than double the samples per run, like the Refrigerated CentriVap, is a meaningfully different proposition for a peptide synthesis or purification lab than it would have been five years ago.</p><h3><strong>Temperature Range: How Cold You Can Go</strong></h3><p>The CentriVap's refrigeration reaches as low as<strong> -10°C</strong>; the SRF110 bottoms out at <strong>-4°C</strong>. Both units heat up to +100°C. That six-degree gap on the cold end isn't dramatic on paper, but for the most heat-labile peptides and enzymes, the lower floor gives operators more margin before a sample is at risk — particularly during longer runs where evaporative cooling has more time to compound any thermal load on the sample.</p><h3><strong>Vortex Speed and Mechanical Flexibility</strong></h3><p>The CentriVap offers an adjustable vortex range from <strong>500 to 1,800 rpm</strong>, while the SRF110 runs up to<strong> 1,725 rpm</strong>. The CentriVap's lower floor is the more useful distinction here — fragile, large, or shear-sensitive samples (think intact proteins or larger peptide constructs) sometimes need to run at reduced rotor speed to avoid mechanical stress, and the CentriVap gives operators that headroom on both ends rather than just a ceiling.</p><h3><strong>Lid Material: Visibility vs. Durability</strong></h3><p>The Refrigerated CentriVap uses a <strong>glass lid</strong>, letting operators see into the chamber during a run. The SRF110 uses an <strong>epoxy-coated aluminum lid</strong>, which trades visibility for added durability. For labs running visually distinct sample batches — colored buffers, multiple project codes, HPLC fractions pulled at different time points — the ability to glance at the chamber without interrupting a run has real workflow value, especially in a core facility setting where one instrument serves multiple research groups.</p><h3><strong>What This Means for Core Facilities</strong></h3><p>Shared instrumentation cores feel throughput and cold-temperature constraints differently than a single-PI lab does. A<a target="_blank" rel="noopener noreferrer" href="https://blog.organomation.com/blog/an-appreciation-for-academic-core-labs"><strong> core running samples from multiple research groups </strong></a>— some doing routine RNA cleanup, others running heat-labile peptide fractions from an HPLC purification step — needs an instrument that won't bottleneck on either axis. The CentriVap's combination of higher per-run capacity and a lower refrigeration floor gives a shared facility more room to serve mixed workloads without forcing every group onto the same conservative settings a less flexible unit would require.</p><h3><strong>Built for the Same Footprint</strong></h3><p>Both units are sized for fume hood placement, with the CentriVap measuring<strong> 15.0 x 27.2 x 13.9 inches </strong>against the SRF110's<strong> 16.62 x 25 x 13.75 inches </strong>— close enough that floor planning isn't a deciding factor either way. Both carry <strong>standard one-year warranties</strong>.</p><h3><strong>The Bottom Line</strong></h3><p>For labs concentrating proteins, RNA, enzymes, or peptide fractions at scale — particularly anyone supporting peptide therapeutic development, where production capacity is already the limiting factor industry-wide — the Labconco Refrigerated CentriVap's combination of higher throughput, lower cold-temperature floor, and lower price makes it the stronger fit. The SRF110 remains a capable option for labs with smaller batch sizes already standardized on Thermo Fisher's modular vacuum ecosystem.</p><p>Organomation distributes the full Labconco CentriVap line, including the Refrigerated and Refrigerated Pro models. Contact our team at sales@organomation.com to talk through rotor configuration, cold trap pairing, and throughput planning for your lab.&nbsp;</p><blockquote><h5><a target="_blank" rel="noopener noreferrer" href="https://explore.organomation.com/labconco-refrigerated-centrivap-vs-thermo-fisher-refrigerated-speedvac"><span><strong>Download the full comparison with pricing here!</strong></span></a></h5></blockquote>

Refrigerated SpeedVac SRF110 vs. CentriVap - Why Sample Capacity Matters More Than Ever for Peptide and Protein Labs

<p><strong>Our Library never stops expanding. What are the most recent contributions to LabRulezLCMS Library in the week of 14th September 2026? Check out new documents from the field of liquid phase, especially HPLC and LC/MS techniques!</strong></p><blockquote><p><span style="font-size:20px;">👉 </span><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/library"><span style="font-size:20px;"><strong>SEARCH THE LARGEST REPOSITORY OF DOCUMENTS ABOUT LCMS AND RELATED TECHNIQUES</strong></span></a></p></blockquote><blockquote><p><strong>👉 Need info about different analytical techniques?</strong> Peek into <a target="_blank" rel="noopener noreferrer" href="https://gcms.labrulez.com/library"><strong>LabRulezGCMS</strong></a> or <a target="_blank" rel="noopener noreferrer" href="https://icpms.labrulez.com/library"><strong>LabRulezICPMS</strong></a> libraries.</p></blockquote><p>This week we bring you application notes by <strong>Agilent Technologies </strong>and <strong>Waters Corporation </strong>and posters by <strong>Shimadzu / AOAC </strong>and<strong> Thermo Fisher Scientific / Metabolomics!</strong></p><h3><strong>1. Agilent Technologies: Improved Analysis of Intact Proteins and Peptides by Reversed Phase HPLC Using the Altura Ultra Inert PLRP-S 1000 Å Column</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/an_altura_ultrainert_column_HPLC_analysis_5994_9322en_agilent_2b3a542647.pdf"><strong>Full PDF for download</strong></a></li></ul><p>Intact protein analysis by reversed-phase HPLC (RP-LC) plays a vital role in quality control for determining the purity of biotherapeutic proteins and improving the identification and quantification of critical quality attributes (CQAs). When coupled to mass spectrometric detection, it allows several things. First, an accurate molecular weight to be determined; second, the identification of variants containing post‑translational modifications (PTMs) and proteoforms; and third, the antibody-to-drug ratio in the case of antibody drug conjugates (ADCs).<sup>1</sup>&nbsp;</p><p>While many RP columns have a silica-based stationary phase to enable broader functionalization, residual acidic silanol groups can interact with basic residues in peptides, proteins, and other biomolecules, resulting in significant peak tailing and loss of chromatographic performance. Polystyrene/divinyl benzene (PS/DVB)-based stationary phases do not contain unintentional adsorption sites. Additionally, larger pore sizes have demonstrated superior chromatographic efficiency through less diffusion restriction into the pore volume and reduction of size exclusion mechanisms, degrading the RP-based selectivity.<sup>2</sup>&nbsp;</p><p>Wide-pore columns like the PLRP-S 1000Å provide an exceptional performance with biomolecules, particularly when combined with MS-compatible mobile phase conditions such as formic acid.&nbsp;</p><p>Even so, some undesirable interactions may be observed when using stainless-steel column hardware. Molecules that possess multiple negative charges (including oligonucleotides, phosphorylated peptides and proteins, and proteins with low isoelectric point in general) may interact with exposed metal ions in stainless-steel column hardware. This can result in the need to "deactivate" new columns by making multiple injections of sample until reproducible results are obtained.&nbsp;</p><p>This application note demonstrates how the new <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=10&amp;search=Altura+Ultra+Inert"><strong>Altura Ultra Inert </strong></a>PLRP-S 1000 Å column serves as an effective high-performance workhorse in the analysis of large, intact biomolecules. Developed to effectively block nonspecific adsorption during separations, Ultra Inert technology reduced passivation time 15-fold and delivered ~ 10% greater recovery for mAbs and ADCs and up to 100% for smaller biomolecules like GLP-1s and small globular proteins.</p><h4><strong>Experimental</strong></h4><h5><strong>Instrumentation&nbsp;</strong></h5><ul><li>Agilent 1290 Multicolumn thermostat (G7116B)&nbsp;</li><li>Agilent 1290 Bio multisampler (G7137A)&nbsp;</li><li>Agilent 1290 Bio high-speed pump (G7132A)&nbsp;</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=10&amp;search=6530"><strong>Agilent 6530 Q-TOF MS system</strong></a>&nbsp;</li></ul><h5><strong>Software and data processing&nbsp;</strong></h5><ul><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=10&amp;search=MassHunter+Workstation"><strong>Agilent MassHunter Workstation, version 10.1&nbsp;</strong></a></li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=10&amp;search=MassHunter+Qualitative+Analysis"><strong>Agilent MassHunter Qualitative Analysis software, version&nbsp;B.07&nbsp;</strong></a></li><li>Agilent DAR calculator, version B01.01</li></ul><h4><strong>Conclusion&nbsp;</strong></h4><p>Intact mass analysis is a critical methodology to determine the purity of biotherapeutics, but due to the chemical complexity of these analytes, nonspecific adsorption from both silica stationary phase and metal column housing can be highly deleterious to separation performance. The Agilent Altura PLRP-S 1000 Å provides a highly robust solution combining the chemical inertness of polystyrene/divinyl benzene stationary phase with the ultra‑inert Altura hardware to dramatically reduce deleterious peak tailing and increase recovery for biotherapeutics. Herein, we see that analyte recovery for both mAbs, ADCs, GLP-1s, and globular proteins are improved versus stainless-steel, while the Altura PLRP-S column is capable of monitoring both quality critical PTMs such as loss of drug payload as well as accurate quantification of ADC DAR.</p><h3><strong>2. Shimadzu / AOAC: Ambient Ionization Mass Spectrometric Detection of Aroma Released During Gummy Chewing</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/aoac_2026_47_2_34c41f762f.pdf"><strong>Full PDF for download</strong></a></li></ul><p>In recent years, there has been growing interest in evaluating flavor using analytical instrumentation, and retronasal aroma during eating is important. In this study, we proposed an analytical method for measuring retronasal aroma during eating using a single quadrupole mass spectrometer (<a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/library?mainauthorItems=1&amp;search=2050"><strong>LCMS-2050</strong></a>) equipped with an ambient ion source (Dark Current Discharge Ionization : DCDI) without pretreatment.</p><h4><strong>Conclusion</strong></h4><p>We developed a simple method for evaluating retronasal aroma using a single quadrupole mass spectrometer with an ambient ionization source. Ambient ionization mass spectrometry (DCDI LCMS-2050) can rapidly measure retronasal aroma during eating. Time-resolved visualization reveals texture-dependent differences in aroma release dynamics among grape-flavored gummies. It is also expected to lead to the visualization of the marriage between food and alcohol. This approach may facilitate objective evaluation of flavor release during consumption and support product formulation and sensory science.</p><h3><strong>3. Thermo Fisher Scientific / Metabolomics: Orbitrap Tribrid Real-Time similarity searching of mzCloud library for guided unknown characterization of tea metabolites</strong></h3><ul><li>Poster</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/po_004849_lsms_rtls_tribrid_apex_small_molecule_metabolomics_po004849_na_en_d0d3156065.pdf"><strong>Full PDF for download</strong></a></li></ul><p>In metabolomics LC-MS data is processed to generate a list of detected compounds with a level of confidence in the identity of each compound based on reference data. This reference data may be spectral data and/or retention time information stored in a library or in silico information generated based on fragmentation rules. These annotated compounds are then used to evaluate biological changes between normal and disease states. One of the major hurdles between collected data and coming to reliable conclusions about the biology is the limited number of standards available to build these libraries. It is common to have hundreds to thousands of compounds detected in a data set that have no library match because there is no commercial standard for that unknown. Instead, there is just an elemental formula and matches from a structure database. These structures can be compared using in silico fragmentation techniques to determine which isomers plausibly match the data. MSn data can help reduce the list of possible matches, but without guidance, ddMS3 may not consistently collect data on the most relevant MS2 fragments to accomplish this.&nbsp;</p><p>In this work we use Real-Time Library Search (RTLS) in a ddMS3 method to help guide the instrument in real time to collect the most relevant data for confirming structural matches.</p><h4><strong>Materials and methods</strong></h4><h5><strong>Test method(s)&nbsp;</strong></h5><p>1 μL aliquots were analyzed using a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/lcms/products?category=48&amp;manufacturerItems=3&amp;search=gold"><strong>Thermo Scientific Hypersil GOLD column</strong></a> on a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/744"><strong>Thermo Scientific Vanquish Horizon UHPLC</strong></a><strong> </strong>coupled with a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/561"><strong>Thermo Scientific Orbitrap IQ-X Tribrid mass spectrometer</strong></a> and <strong>Thermo Scientific Orbitrap Tribrid Apex Small Molecule mass spectrometer</strong>. RTLS was run in similarity mode using the offline version of <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1764"><strong>Thermo Scientific mzCloud library</strong></a>.&nbsp;</p><h5><strong>Data analysis&nbsp;</strong></h5><p>Data was processed using <strong>Thermo Scientific Freestyle and </strong><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1759"><strong>Compound Discoverer software</strong></a><strong>.</strong></p><h4><strong>Conclusions&nbsp;</strong></h4><p>Tea extracts were analyzed using RTLS to find the most similar compound in the offline version of the mzCloud library and trigger MS3 on the highest m/z matching and non-matching fragments. This provided additional information to confirm similarity and provide insight on shared sub-structures to the library compound as well as additional information on the portions of the structure that were unique to the experimental compound.</p><h3><strong>4. Waters Corporation: The Quantification of Glucagon-like Peptide Receptor Agonists (GLP-1 RAs) in Plasma Extracts Using Capillary UHPLC-MS/MS</strong></h3><ul><li>Application note</li><li><a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/pdf/720009537_en_0068921516.pdf"><strong>Full PDF for download</strong></a></li></ul><div><div><section><div><div><div><div><div><div><h5><strong>Benefits&nbsp;</strong></h5><ul><li>10-fold improvement in sensitivity&nbsp;</li><li>Robust methodology for &gt;500 injections&nbsp;</li><li>Reduced solvent usage&nbsp;</li><li>No need for complex nanospray MS source</li></ul><p>Obesity represents, perhaps, the largest healthcare challenge, affecting approximately 1.3 billion people globally, contributing to a diverse range of chronic diseases e.g., metabolic, cardiovascular, muscular skeletal, and multiple cancers.1 The rapid growth of obesity and associated global healthcare costs means there is a critical need for safe effective treatments.2 GLP-1 RA initially developed for type 2 diabetes have shown clinical efficacy as weight loss medicines.2 These drugs mimic the action of gut hormones which regulate energy metabolism and appetite by interacting with the hypothalamus, brain stem etc., resulting in weight loss. The success of these GLP-1 RAs is associated with their on-target efficacy and long duration of action,3 e.g., half-life of semaglutide t½ = 160–180 hours3 cf. 1–2 minutes for human GLP-1.4 The long half-life of these GLP-1 RAs results in low, sub ng/mL plasma levels 48–72 hours after dosing, which requires a high sensitivity bioanalytical assay to accurately quantify the plasma concentrations5 and define the PK elimination phase.&nbsp;</p><p>Tandem quadrupole electrospray ionization (ESI) mass spectrometry, operated in multiple reaction monitoring (MRM) mode, coupled with 2.1 mm ID ultra-high performance liquid chromatography (UHPLC) is the dominant technology platform for quantitative bioanalysis. As next generation GIP/GLP-1 RAs promise to be more potent, resulting in lower dosing levels and plasma levels, there is a need for more sensitive analytical methodologies to support drug metabolism and pharmacokinetics (DMPK) studies. Capillary/nano LC-MS/MS have been extensively employed in proteomics to increase analytical sensitivity and enable small volume analysis.5 This sensitivity increase is derived from a combination of the superior ionization efficiency at low flow rates and analyte concentration due to the smaller column geometry.6 This application note illustrates the use of capillary (300 µm) UHPLC-MS/MS (MRM) to affect 10-fold improvement in GLP-1-RAs peak response in human plasma extracts, and detection limits as low as 20 pg/mL for tirzepatide.</p><h4><strong>Experimental</strong></h4><p>Capillary chromatography was performed on an <strong>ACQUITY™ M-class Chromatography System</strong> connected to a <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/195"><strong>Xevo™ TQ-XS Mass Spectrometer</strong></a> (Waters Corporation, Wilmslow, UK) equipped with a microflow probe. Capillary UHPLC separations were performed on an <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1952"><strong>ACQUITY Premier Peptide CSH C18</strong></a>, 300 Å, 1.7 µm, 300 µm x 50 mm Chromatography Column.</p><p>MS analysis was performed at unit mass resolution using positive ESI at a capillary voltage of 3.0 kV, with a cone voltage of 32 V. The cone gas flow, desolvation gas flow, and desolvation gas temperature were 50 L/h, 300 L/h and 600 °C, respectively. The data were analyzed using <a target="_blank" rel="noopener noreferrer" href="https://labrulez.com/en-us/all/products/1544"><strong>waters_connect™ Software</strong></a><strong>,</strong> and MRM transitions used to monitored for the MS/MS detection of liraglutide, exenatide, semaglutide and tirzepatide were as follows: liraglutide 938.7 → 1128.4, exenatide 838 → 396, semaglutide 1029.2 → 1238.1, and tirzepatide 1204.2 → 396.2. Data analysis was performed using <strong>MS Quan Software.</strong></p><h4><strong>Conclusion</strong></h4><p>Bioanalysis plays a critical role in the drug discovery and development processes providing data to support DMPK, safety assessment, pharmacokinetics/pharmacodynamics (PK/PD), and clinical development studies. The development of new, more potent medicines, innovating delivery platforms, micro sampling, and new approach methodologies (e.g., organ on a chip) all require greater levels of analytical sensitivity. Capillary scale UHPLCMS/MS offers the potential to improve bioanalytical detection limits up to 10-fold, without the need for long analysis times and complex operation associated with nano spray LC-MS/MS. Here, the application of capillary (300 µm ID) scale chromatography for the detection of GLP-1 RAs in human plasma extracts at levels as low as 20 pg/mL with robustness over 500 injections was demonstrated.</p></div></div></div></div></div></div></section></div></div>

News from LabRulezLCMS Library - Week 38, 2026

Article

Product

Application

Science and research

Poster

Since its establishment in 2011, CEITEC has quickly developed into a cutting-edge infrastructure for research which performs highly alongside the best institutes in Europe. Among the main priorities of CEITEC are the promotion of a motivating and dynamic international scientific environment, the provision of state-of-the-art research infrastructure, and the policy of open communication and equal opportunities.

CEITEC

Everything from the world of analytical chemistry in one place. We connect people in solving their problems. At Labrulez you will find all the necessary information easily, quickly and clearly. Stop searching and start finding.

LabRulez

Organomation, founded in 1959, designs and manufactures high-quality nitrogen evaporators and extraction systems. Known for innovation and durability, their lab instruments are used globally for efficient sample preparation with strong customer support.

Organomation

Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system

The new Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system delivers exactly what a busy analytical testing lab is looking for: consistently excellent results-every shift, every day, for every operator.

<h3><strong>Welcome to the evolution of everyday IC reliability</strong></h3><p>The new<strong> Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system</strong> makes ion analysis simpler and more intuitive than ever before. And it delivers exactly what a busy analytical testing lab is looking for: <strong>consistently excellent results-every shift, every day, for every operator.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_2_6400708696.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_2_6400708696.jpg 245w," sizes="100vw" width="825" height="498"></p><h3><strong>SIMPLE, INTUITIVE USER EXPERIENCE&nbsp;</strong></h3><ul><li><strong>Smart, function-driven design</strong> lets you quickly and safely access everything on the instrument—no hard-to-reach compartments, and no step stools or extra tools needed!</li><li><strong>Automated startup and shutdown routines</strong> ensure the system is quickly ready for the day’s work without user intervention.&nbsp;</li><li><strong>Built-in how-to videos</strong> reduce training time and simplify setup and operation.</li></ul><h3><strong>ULTRA-RELIABLE PERFORMANCE&nbsp;</strong></h3><ul><li><strong>Advanced high-performance pump technology and electronics</strong> let you take advantage of a wider range of columns and chemistries to improve the speed and quality of your results.</li><li><strong>Fast, flexible, convenient electrolytic suppression: </strong>Just connect the suppressor; no external pump or offline conditioning needed for regeneration.</li><li><strong>Reagent-free IC (RFIC™) capability</strong> makes eluent preparation as simple as “just add water,” while ensuring more consistent results and enabling optimized gradient separations.</li></ul><h3><strong>EASILY CONFIGURABLE AND UPGRADEABLE</strong></h3><ul><li><strong>Versatile, adaptable platform</strong> lets you configure the exact Dionex Inuvion IC system for today’s needs and budget, with confidence that your system will also meet your future needs.</li><li><strong>Multiple options and peripherals </strong>extend IC capabilities, letting you easily—and cost-effectively—adapt to changing sample types and workflow requirements.</li></ul><h3><strong>Simply the best system for everyday ion analysis</strong></h3><figure class="image"><img style="aspect-ratio:1107/755;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_d855feb2a8.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_d855feb2a8.jpg 229w," sizes="100vw" width="1107" height="755"></figure><p><strong>1. Operator-friendly engineering </strong>saves time and reduces errors by allowing easy, unobstructed access to all components, connections and consumables</p><p><strong>2. Compact design </strong>helps you make the most of valuable bench space</p><p><strong>3. Digital gas pressure regulator </strong>increases precision of gas delivery for maximum day-to-day consistency (optional)</p><p><strong>4. Temperature-controlled conductivity cell </strong>improves reproducibility and ensures baseline stability</p><p><strong>5. Vacuum degassing capability</strong> enables more consistent peak identification from smoother baselines</p><p><strong>6. Seal wash pump</strong> reduces maintenance costs when using manually prepared eluents (optional)&nbsp;</p><p><strong>7. Reagent-free IC (RFIC)</strong> saves time and ensures greater day-to-day and operator-to-operator consistency, while also allowing the use of gradient separations</p><p><strong>8. Electrolytic suppression</strong> entirely eliminates the need for manual regenerant preparation (or, opt for a continuously regenerated, always- ready-to-go chemical suppressor)</p><p><strong>9. Thermo Scientific™ Dionex™ IC PEEK Viper™ fittings</strong> ensure confident, low dead volume connections every time—no tools required! (optional)</p><p><strong>10. Integrated column heater</strong> minimizes the impact of fluctuations in lab temperature that can adversely affect results (optional)</p><p><strong>11. 6- or 10-port auxiliary valve</strong> lets you automate in-line sample preparation</p><p><strong>12. State-of-the-art high-pressure pump (up to 5000 psi)</strong> lets you increase flow rates with smaller particle columns to reduce run times or add additional separation capacity with longer column length</p><p><strong>13. System self-diagnostics </strong>automatically detect any issues with hardware and consumables</p><p><strong>14. Self-service capabilities and user-swappable parts</strong> help you get back up and running in a hurry Automatic eluent monitor alerts the operator to low solution levels, avoiding potential system damage or failed runs (optional)</p><p><strong>15. Automatic eluent monitor </strong>alerts the operator to low solution levels, avoiding potential system damage or failed runs (optional)</p><h3><strong>Flexible, adaptable Dionex Inuvion platform</strong></h3><p>You can <strong>configure your Dionex Inuvion system</strong> to meet specific analytical and budget requirements, and easily reconfigure as needed. Multiple configurations and peripherals extend IC capabilities, letting you easily-and cost-effectively-adapt to changing sample types and workflow requirements.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_3_fa8233bcd4.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_Inuvion_ion_chromatography_system_3_fa8233bcd4.jpg 245w," sizes="100vw" width="1246" height="572"></p><h3><strong>Consistently excellent results every day</strong></h3><p>The <strong>Dionex Inuvion IC system supports a full range of columns </strong>to improve the speed and quality of results, for both<strong> anions and cations.</strong> Expanded capabilities, such as Reagent-Free IC (RFIC), enhance operator-to-operator consistency, while enabling the use of eluent gradients to optimize separations.</p><h4><strong>Rapid results</strong></h4><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Obr_2_Ukazka_rychle_separace_zakladnich_aniontu_s_uhlicitanovou_MF_Zkraceni_doby_analyzy_diky_typu_kolony_a_vyssimu_prutoku_0e610b919d.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system: Figure 1. Elution of seven common inorganic anions using carbonate eluent. Short columns and fast flow rates let you reduce run times." srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Obr_2_Ukazka_rychle_separace_zakladnich_aniontu_s_uhlicitanovou_MF_Zkraceni_doby_analyzy_diky_typu_kolony_a_vyssimu_prutoku_0e610b919d.jpg 245w," sizes="100vw" width="1622" height="739"></p><h4><strong>Exceptional reproducibility</strong></h4><figure class="image"><img style="aspect-ratio:1693/754;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Obr_3_Ukazka_reprodukovatelnosti_analyzy_zakladnich_aniontu_40_nastriku_Spickova_technologie_cerpadla_a_elektronika_pristroje_poskytuji_konzistentni_a_reprodukovatelne_vysledky_f66e7430cf.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system: Figure 2. Overlay of 40 replicate injections. State-of-the-art pump technology and Electronics deliver consistent, reproducible results." width="1693" height="754"></figure><h4><strong>Increased sensitivity and consistency</strong></h4><figure class="image"><img style="aspect-ratio:1860/836;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Obr_4_Ukazka_vysoce_citlive_analyzy_aniontu_ve_vodach_Eluent_generator_KOH_a_elektrolyticka_suprese_snizuji_pozadi_cimz_dochazi_ke_zvyseni_citlivosti_da55facfd0.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system: Figure 3. Determination of inorganic anions in drinking and surface waters. KOH eluent generation and electrolytic suppression yield lower backgrounds for greater sensitivity and increased day-to-day consistency." width="1860" height="836"></figure><h4><strong>Method optimization</strong></h4><figure class="image"><img style="aspect-ratio:1799/889;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Obr_5_Ukazka_optimalizace_metody_zkraceni_doby_analyzy_pouzitim_gradientu_mobilni_faze_fc1fbe9cb0.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system: Figure 4. Comparison of isocratic and gradient runs using eluent generation. Reduce run length and sharpen later-eluting peaks with the same ease as an isocratic run with no need for two separate eluents or a proportioning pump." width="1799" height="889"></figure><h3><strong>Compliance-ready Chromeleon CDS</strong></h3><p>A trusted industry standard all over the world, ”Simply Intelligent”<strong> </strong><a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Thermo Scientific™ Chromeleon™ Chromatography Data System (CDS) software</strong></a><strong> </strong>brings out the full power of the Dionex Inuvion IC system. Easy to learn and easy to use, it automates and optimizes daily tasks and helps even inexperienced users achieve consistent, high quality results.</p><figure class="image"><img style="aspect-ratio:3700/1660;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Thermo_Scientific_Dionex_Inuvion_2_303a6eb73b.jpg" alt="Thermo Scientific™ Dionex™ Inuvion™ ion chromatography system." width="3700" height="1660"></figure>

Thermo Scientific Stellar Mass Spectrometer

Move biomarker candidates from discovery to validation more efficiently, confidently, and at lower cost with breakthroughs in extended scale, massive throughput, higher sensitivity, greater specificity, and unrivaled productivity.

<div><div id="container-a1c36dfacf"><div><div><div id="text-913638046"><p><strong>A new paradigm for targeted quantitation.&nbsp;Move biomarker candidates from discovery to validation more efficiently, confidently, and at lower cost with breakthroughs in extended scale, massive throughput, higher sensitivity, greater specificity, and unrivaled productivity.</strong></p><p>The Thermo Scientific Stellar Mass Spectrometer introduces revolutionary technology combining robust quantitation with the specificity of rapid full scan MS<sup>n</sup>&nbsp;acquisition creating unrivaled improvements in laboratory productivity.</p><div><div id="text-801893275"><h3><strong>Expanded experimental capabilities to meet the most challenging biomarker verification</strong></h3></div></div><div><div id="container-1e8e478f3a"><div><div><div id="text-1204752335"><p>The Thermo Scientific Stellar Mass Spectrometer offers an array of data acquisition capabilities to deliver robust and reproducible quantitation for a wide range of analytes across an extended dynamic range.</p></div></div></div></div></div><h4><strong>System highlights</strong></h4><div><div id="container-a89a56f063"><div><div><div id="text-451891225"><h5><strong>Improve ionization efficiency for more compounds at higher LC flow rates&nbsp;</strong></h5></div></div><div><div id="text-1671602085"><p>For a wider range of compounds separated using liquid chromatography operated at analytical flow rates, the Stellar Mass Spectrometer comes equipped with the Thermo Scientific OptaMax Plus Ion Source, which can deliver higher vaporizer temperatures to improve desolvation and ionization potentials.</p></div></div></div></div></div><figure class="image"><img style="aspect-ratio:1290/725;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_Stellar_revolucni_hmotnostni_spektrometr_SF_Sys_Opta_Max_c303cf500a.jpg" alt="Thermo Fisher Scientific: Thermo Scientific Stellar Mass Spectrometer - SF Sys OptaMax" width="1290" height="725"></figure><div><div id="container-d79c3b2946"><div><div><div id="text-251514658"><h5><strong>Spend less time on instrument set-up and focus on the science</strong></h5></div></div><div><div id="text-989104128"><p>Trigger on-demand or scheduled system calibrations remotely and without disruption to your LC-MS system with the integrated Auto-Ready ion source.</p></div></div></div></div></div><div><div id="container-81dd07c9bb"><div><div><div id="text-1289282711"><h5><strong>Improve ion utilization by extending the capabilities of the new collision cell</strong></h5></div></div><div><div id="text-1641484825"><p>The ion concentrating routing multipole (ICRM) is a curved collision cell performing both beam-type fragmentation (HCD) and precursor/product ion accumulation capabilities as controlled by dynamic automatic gain control (AGC) with synchronized ion packet release to the high-pressure linear ion trap for downstream manipulation or detection.</p></div></div></div></div></div><figure class="image"><img style="aspect-ratio:1290/725;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_Stellar_revolucni_hmotnostni_spektrometr_SF_Sys_ICRM_3b2326f3af.jpg" alt="Thermo Fisher Scientific: Thermo Scientific Stellar Mass Spectrometer - SF Sys ICRM" width="1290" height="725"></figure><div><div id="container-dbf5a6cdd9"><div><div><div id="text-813962034"><h5><strong>Efficiently manage ion populations for fast and sensitive analysis</strong></h5></div></div><div><div id="text-2033771024"><p>The&nbsp;hyper-fast dual-pressure linear ion trap mass analyzer expands analytical capabilities while maximizing fast, high-quality data acquisition.</p><p>The differential neutral pressures maintained in the high- and low-pressure linear ion traps prepares ions for higher-order manipulation or fast and sensitive ion ejection at scan rates up to 220 kDa/S, but typically operates at 125 kDa/S for robust data acquisition.</p></div></div></div></div></div><div><div id="container-9a523f34e0"><div><div><div id="text-1491120095"><h5><strong>Extended analytical capabilities to increase laboratory productivity</strong></h5></div></div><div><div id="text-328051555"><p>The high-pressure linear ion trap maximizes ion packet manipulation enabling multi-notch RF excitation for dissociation or ejection for SIM, higher order MS<sup>n</sup>, SPS MS<sup>3</sup>, or data-independent acquisition (DIA) to address the most challenging quantitative experiments.&nbsp;</p><div><div id="container-82e5907416"><div><div><div id="text-693866740"><h5><strong>Leverage single ion detection sensitivity to address the most challenging quantitation demands</strong></h5></div></div><div><div id="text-737565098"><p>Efficient and sensitive ion detection drives improved quantitative performance at scale. The dual conversion dynode configuration coupled to the photomultiplier tube detects ca. 84% of trapped ions for single ion sensitivity.</p></div></div></div></div></div></div></div></div></div></div><figure class="image"><img style="aspect-ratio:2048/1152;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_Stellar_hmotnostni_spektrometr_SF_Sys_Extended_Scale_750dc20128.jpg" alt="Thermo Fisher Scientific: Thermo Scientific Stellar Mass Spectrometer - SF Sys Extended Scale" width="2048" height="1152"></figure><div><div id="text-1993749933"><h5><strong>Automated intelligence manages tMSn acquisition</strong></h5></div></div><div><div id="text-1206797739"><p>Streamline tMSn method creation and data acquisition management. PRM Conductor software effectively and efficiently creates robust targeted quantitative methods and manages reproducible data acquisition and processing.</p></div></div><div><div id="container-b03b606507"><div><div><div id="text-2005266584"><h5><strong>Maximize data completeness with the Adaptive RT routine</strong></h5></div></div><div><div id="text-671832198"><p>Eliminate the cost and time of optimizing RT kits to the study samples to boost timed/scheduled data acquisition performance using the Adaptive RT routine.</p><p>The method leverages a novel real-time mapping routine to dynamically adjust timed/scheduled data acquisition windows at narrower time intervals to eliminate missing values that compromise data quality.&nbsp;</p></div></div></div></div></div><figure class="image"><img style="aspect-ratio:1290/654;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_Stellar_revolucni_hmotnostni_spektrometr_SF_Sys_PRM_Conductor_5b596e7e4c.jpg" alt="Thermo Fisher Scientific: Thermo Scientific Stellar Mass Spectrometer - SF Sys PRM Conductor" width="1290" height="654"></figure><div><div id="container-a192ba4b83"><div><div><div id="container-38d4c699d2"><div><div><div id="text-1578189934"><h5><strong>Industry-leading polarity switching speeds increase laboratory productivity</strong></h5></div></div><div><div id="text-1173595596"><p>Reduce the time, cost, and challenges associated with creating and implementing highly multiplexed quantitative metabolite analysis. Fast polarity switching speeds enable comprehensive compound interrogation in +ESI and -ESI at all MS<sup>n</sup> levels on an LC timescale.</p><div><div id="container-b5fb525888"><div><div><div id="text-18006314"><h5><strong>Environmentally friendly dry pumps decrease energy usage and maintenance</strong></h5></div></div><div><div id="text-1704557304"><p>Changing from two oil-based fore pumps to a single dry pump reduces heat output by 22% and decreases maintenance.</p><p>The use of a single dry pump also eliminates oil vapors and the need for oil checks and changes.</p><h3><strong>Solutions for additional research support</strong></h3><div><h4><strong>Translational proteomics</strong></h4><p>The Stellar Mass Spectrometer offers new possibilities for translational proteomics with improved specificity for greater quantitative performance at scale.</p><h4><strong>Quantitative proteomics</strong></h4><p>Accurate and precise quantitation for label-free and TMT multiplexing sample analysis strategies with the Stellar Mass Spectrometer.</p><div><h4><strong>Metabolomics and Lipidomics</strong></h4><p>Extended analytical capabilities quantify more metabolites and lipids with greater specificity using faster liquid chromatography gradients to increase laboratory productivity.</p></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div></div>

Thermo Scientific™ GENESYS™ 50 UV-Vis Spectrophotometer

Perform routine measurements for quality control or teaching in the chemistry classroom with rugged Thermo Scientific™ GENESYS 50 UV-Vis Spectrophotometer.

<h4><strong>GENESYS - developed for users, designed for results</strong></h4><p>Built on the foundation of 60 years of spectroscopy experience, the next generation Thermo Scientific™ GENESYS™ family of Vis/UV-Vis spectrophotometers provides exceptional performance with a contemporary design.</p><ul><li>Start taking measurements immediately with the simple-to-use, high-resolution, color-display start menu</li><li>Exchange samples with ease with large, accessible sample compartment</li><li>Save your data fast any way you want it with multiple data-export options</li></ul><p>There is a GENESYS spectrophotometer you can count on to provide accurate, reproducible results for your application requirements.</p><h3><strong>GENESYS 50 UV-Vis Spectrophotometer</strong></h3><p><strong>For teaching labs, research labs and industrial QC requiring robust construction, ease-of-use and software capability.</strong></p><h5><strong>Advanced usability, modern functionality</strong></h5><ul><li>7-inch, high-resolution touchscreen interface</li><li>Local control increases speed and reliability for routine analysis</li><li>Large sample compartment with front access simplifies sample handling</li><li>Wi-Fi ready - save data and methods, print results from on-board control</li></ul><h5><strong>Designed for</strong></h5><ul><li>Chemistry labs</li><li>Routine measurements</li><li>Moderate throughput requirements</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_Genesys_50_Kyveta_bae9677ae0.jpg" alt="Thermo Scientific™ GENESYS™ 50 UV-Vis Spectrophotometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Scientific_Genesys_50_Kyveta_bae9677ae0.jpg 188w," sizes="100vw" width="534" height="443"></p><h3><strong>Walk-up convenience</strong></h3><p><strong>Simple-to-use, touchscreen user interface features the methods and applications most important to you.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Genesys_spectrophotometers_ae282fe726.jpg" alt="Thermo Scientific GENESYS Spectrophotometers" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Genesys_spectrophotometers_ae282fe726.jpg 239w," sizes="100vw" width="1422" height="928"></p><h5><strong>Flexible computer control</strong></h5><p>Optional VISIONlite software offers complete control from a Microsoft ® Windows ® computer providing applications for:</p><ul><li>Scanning</li><li>Quantitative analysis</li><li>Kinetics</li><li>Fixed wavelength measurements</li></ul><h3><strong>GENESYS 50 UV-Vis Spectrophotometer Specifications</strong></h3><ul><li><strong>Baseline Flatness:</strong> ±0.002 A</li><li><strong>Compartments:</strong>&nbsp;<ul><li>Accessible from top, front or side</li><li>Able to accommodate cells up to 100 mm cells</li><li>Available accessory for test-tubes up to 25 mm diameter and 150 mm height</li><li>Removable, washable sample compartment liner with magnetic placement and hold-down</li></ul></li><li><strong>Connections:</strong>&nbsp;<ul><li>Single USB-A</li><li>Duplex USB-A</li><li>Export data to network or PC via USB, Ethernet, or Wi-Fi USB adaptor, available</li><li>Print via USB, Ethernet or Wi-Fi USB adaptor available</li></ul></li><li><strong>Dimensions (L x W x H):</strong> 35.5 x 38.5 x 19.5 cm</li><li><strong>Drift:</strong> (At 500 nm after 1 hour warmup) &lt;0.0005 A/hr.</li><li><strong>Electrical Requirements:</strong> External AC to DC converter. Voltage and Frequency (Hz) selected automatically, 100/240 V, 50/60 Hz</li><li><strong>Includes:</strong> GENESYS 50 Spectrophotometer</li><li><strong>Keypad:</strong> Touchscreen</li><li><strong>Lamp Life:</strong> &gt; 5 years typical, 3 years guaranteed</li><li><strong>Noise:</strong> (RMS at 500 nm 60 consecutive measurements)<ul><li>≤0.00020A at 0A at 260 and 500 nm</li><li>≤0.00030A at 1A at 260 and 500 nm</li><li>≤0.00040A at 2A at 260 and 500 nm</li></ul></li><li><strong>Optical Design:</strong> Dual Beam</li><li><strong>Photometric Accuracy:</strong> ±0.002A at 0.5A, ±0.004A at 1.0A, ±0.008 A at 2.0 A</li><li><strong>Photometric Display:</strong> -3A to +5A</li><li><strong>Photometric Range:</strong> –2A to +3.5A</li><li><strong>Photometric Repeatability:</strong> ±0.001 A at 1 A measured at 1.0 A at 546 nm</li><li><strong>Printer Included:</strong> Snap-on printer available</li><li><strong>Scan Speed:</strong> Slow, medium and fast – up to 1600 nm/min.</li><li><strong>Stray Light:</strong> &lt; 1.0%T 198 nm (KCl) , &lt;0.05%T at 220 nm (NaI), &lt;0.03%T at 340 nm (NaNO<sub>2</sub>)</li><li><strong>Warranty:</strong> 2 yrs std + 1 yr ext upon reg</li><li><strong>Wavelength Accuracy:</strong> ±0.5 nm</li><li><strong>Wavelength Data Interval:</strong> 0.2 nm, 0.5 nm, 1 nm, 2 nm, 5 nm</li><li><strong>Wavelength Repeatability:</strong> &lt; ±0.2 nm</li><li><strong>Weight (Metric):</strong> 7.5 kg</li><li><strong>Detector Type:</strong> Dual Silicon Photodiodes</li><li><strong>Display:</strong> 7 in. High Definition Color Touchscreen, Fixed, 800 x 1280 pixels</li><li><strong>Spectral Bandwidth:</strong> 2 nm</li><li><strong>Wavelength Range:</strong> 190 to 1100 nm</li><li><strong>Unit Size:</strong> Each</li></ul>

Thermo Scientific™ GENESYS™ 150 UV-Vis Spectrophotometer

Perform quantitative measurements in routine industrial QA/QC or university chemistry labs with the automated and network-capable Thermo Scientific™ GENESYS 150 UV-Vis Spectrophotometer.

<h4><strong>GENESYS - developed for users, designed for results</strong></h4><p>Built on the foundation of 60 years of spectroscopy experience, the next generation Thermo Scientific™ GENESYS™ family of Vis/UV-Vis spectrophotometers provides exceptional performance with a contemporary design.</p><ul><li>Start taking measurements immediately with the simple-to-use, high-resolution, color-display start menu</li><li>Exchange samples with ease with large, accessible sample compartment</li><li>Save your data fast any way you want it with multiple data-export options</li></ul><p>There is a GENESYS spectrophotometer you can count on to provide accurate, reproducible results for your application requirements.</p><h3><strong>GENESYS 150 UV-Vis Spectrophotometer</strong></h3><p><strong>For advanced teaching labs, R&amp;D, research and life science applications requiring higher throughput or temperature control.</strong></p><h5><strong>Elite performance, enhanced capabilities</strong></h5><ul><li>7-inch, high-resolution touchscreen interface</li><li>Local control increases speed and reliability for routine analysis</li><li>Large sample compartment with front access simplifies sample handling</li><li>Wi-Fi ready - save data and methods, print results from on-board control</li></ul><h5><strong>Designed for</strong></h5><ul><li>Chemistry labs</li><li>Routine measurements</li><li>Moderate throughput requirements</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_vis_spektrofotometr_genesys_150_titul_B_a202c02cea.jpg" alt="Thermo Scientific™ GENESYS™ 150 Uv-Vis Spectrophotometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Scientific_vis_spektrofotometr_genesys_150_titul_B_a202c02cea.jpg 180w," sizes="100vw" width="415" height="360"></p><h3><strong>Walk-up convenience</strong></h3><p><strong>Simple-to-use, touchscreen user interface features the methods and applications most important to you.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Genesys_spectrophotometers_ae282fe726.jpg" alt="Thermo Scientific: Genesys spectrophotometers" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Genesys_spectrophotometers_ae282fe726.jpg 239w," sizes="100vw" width="1422" height="928"></p><h5><strong>Flexible computer control</strong></h5><p>Optional VISIONlite software offers complete control from a Microsoft ® Windows ® computer providing applications for:</p><ul><li>Scanning</li><li>Quantitative analysis</li><li>Kinetics</li><li>Fixed wavelength measurements</li></ul><h3><strong>GENESYS 150 UV-Vis Spectrophotometer Specifications</strong></h3><ul><li><strong>Baseline Flatness:</strong> ±0.002 A</li><li><strong>Compartments:</strong> Accommodates (optional):<ul><li>8-position cell changer</li><li>4-position cell changer (long path cells)</li><li>Peltier thermostatted cell holder (20–60 °C)</li><li>Sipper accessory</li><li>Fiber optic probe coupler</li></ul></li><li><strong>Connections:</strong>&nbsp;<ul><li>Single USB-A</li><li>Duplex USB-A</li><li>Export data to network or PC via USB, Ethernet, or Wi-Fi USB adaptor, available</li><li>Print via USB, Ethernet or Wi-Fi USB adaptor available</li></ul></li><li><strong>Dimensions (L x W x H):</strong> 35.5 x 38.5 x 19.5 cm</li><li><strong>Drift:</strong> (At 500 nm after 1 hour warmup) &lt;0.0005 A/hr.</li><li><strong>Electrical Requirements:</strong> External AC to DC converter. Voltage and Frequency (Hz) selected automatically, 100/240 V, 50/60 Hz</li><li><strong>Includes:</strong> Genesys 150 Spectrophotometer</li><li><strong>Keypad:</strong> Touchscreen</li><li><strong>Lamp Life:</strong> &gt; 5 years typical, 3 years guaranteed</li><li><strong>Noise:</strong> (RMS at 500 nm 60 consecutive measurements)<ul><li>≤0.00020A at 0A at 260 and 500 nm</li><li>≤0.00030A at 1A at 260 and 500 nm</li><li>≤0.00040A at 2A at 260 and 500 nm</li></ul></li><li><strong>Optical Design:</strong> Dual Beam</li><li><strong>Photometric Accuracy:</strong> ±0.002A at 0.5A, ±0.004A at 1.0A, ±0.008 A at 2.0 A</li><li><strong>Photometric Display:</strong> -3A to +5A</li><li><strong>Photometric Range:</strong> –2A to +3.5A</li><li><strong>Photometric Repeatability:</strong> ±0.001 A at 1 A measured at 1.0 A at 546 nm</li><li><strong>Printer Included:</strong> Snap-on printer available</li><li><strong>Scan Speed:</strong> Slow, medium and fast – up to 1600 nm/min.</li><li><strong>Stray Light:</strong> &lt; 1.0%T 198 nm (KCl) , &lt;0.05%T at 220 nm (NaI), &lt;0.03%T at 340 nm (NaNO<sub>2</sub>)</li><li><strong>Warranty:</strong> 2 yrs std + 1 yr ext upon reg</li><li><strong>Wavelength Accuracy:</strong> ±0.5 nm</li><li><strong>Wavelength Data Interval:</strong> 0.2 nm, 0.5 nm, 1 nm, 2 nm, 5 nm</li><li><strong>Wavelength Repeatability:</strong> &lt; ±0.2 nm</li><li><strong>Weight (Metric):</strong> 7.5 kg</li><li><strong>Detector Type:</strong> Dual Silicon Photodiodes</li><li><strong>Display:</strong> 7 in. High Definition Color Touchscreen, Tiltable, 800 x 1280 pixels</li><li><strong>Spectral Bandwidth:</strong> 2 nm</li><li><strong>Wavelength Range:</strong> 190 to 1100 nm</li><li><strong>Unit Size:</strong> Each</li></ul>

Thermo Scientific™ GENESYS™ 180 UV-Vis Spectrophotometer

Perform high throughput quantitative UV-Vis measurements where a double beam is required as a reference cell position with the  Thermo Scientific™ GENESYS™ 180 UV-Visible Spectrophotometer. 

<h4><strong>GENESYS - developed for users, designed for results</strong></h4><p>Built on the foundation of 60 years of spectroscopy experience, the next generation Thermo Scientific™ GENESYS™ family of Vis/UV-Vis spectrophotometers provides exceptional performance with a contemporary design.</p><ul><li>Start taking measurements immediately with the simple-to-use, high-resolution, color-display start menu</li><li>Exchange samples with ease with large, accessible sample compartment</li><li>Save your data fast any way you want it with multiple data-export options</li></ul><p>There is a GENESYS spectrophotometer you can count on to provide accurate, reproducible results for your application requirements.</p><h3><strong>GENESYS 180 UV-Vis Spectrophotometer</strong></h3><p><strong>For laboratories requiring double beam with a reference cell position.</strong></p><h5><strong>High-throughput ready</strong></h5><ul><li>Double-beam optics</li><li>Ideal solution when a reference beam is required, such as for kinetics</li><li>8-cell changer standard</li><li>Make measurements outside the sample compartment without cuvettes using fiber optic coupler and probe</li></ul><p><strong>Designed for laboratories requiring double beam operation with a reference cell position.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Thermo_Scientific_vis_spektrofotometr_genesys_180_titul_D_open_90df06abb8.jpg" alt="Thermo Scientific™ GENESYS™ 180 UV-Vis Spectrophotometer" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Pragolab_Thermo_Scientific_vis_spektrofotometr_genesys_180_titul_D_open_90df06abb8.jpg 171w," sizes="100vw" width="467" height="427"></p><h3><strong>Walk-up convenience</strong></h3><p><strong>Simple-to-use, touchscreen user interface features the methods and applications most important to you.</strong></p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Genesys_spectrophotometers_ae282fe726.jpg" alt="Thermo Scientific Genesys spectrophotometers" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Genesys_spectrophotometers_ae282fe726.jpg 239w," sizes="100vw" width="1422" height="928"></p><h5><strong>Flexible computer control</strong></h5><p>Optional VISIONlite software offers complete control from a Microsoft ® Windows ® computer providing applications for:</p><ul><li>Scanning</li><li>Quantitative analysis</li><li>Kinetics</li><li>Fixed wavelength measurements</li></ul><h3><strong>GENESYS 180 UV-Vis Spectrophotometer Specifications</strong></h3><ul><li><strong>Baseline Flatness:</strong> ±0.002 A</li><li><strong>Compartments:</strong><ul><li>8-position cell changer (standard)</li><li>Also accommodates (optional):<ul><li>4-position cell changer (long path cells)</li><li>Peltier thermostatted cell holder (20–60 °C)</li><li>Sipper accessory</li><li>Fiber optic probe coupler</li></ul></li></ul></li><li><strong>Connections:</strong>&nbsp;<ul><li>Single USB-A</li><li>Duplex USB-A</li><li>Export data to network or PC via USB, Ethernet, or Wi-Fi USB adaptor, available</li><li>Print via USB, Ethernet or Wi-Fi USB adaptor available</li></ul></li><li><strong>Dimensions (L x W x H):</strong> 35.5 x 38.5 x 19.5 cm</li><li><strong>Drift:</strong> (At 500 nm after 1 hour warmup) &lt;0.0005 A/hr.</li><li><strong>Electrical Requirements:</strong> External AC to DC converter. Voltage and Frequency (Hz) selected automatically, 100/240 V, 50/60 Hz</li><li><strong>Keypad:</strong> Touchscreen</li><li><strong>Lamp Life:</strong> &gt; 5 years typical, 3 years guaranteed</li><li><strong>Noise:</strong> (RMS at 500 nm 60 consecutive measurements)<ul><li>≤0.00020A at 0A at 260 and 500 nm</li><li>≤0.00030A at 1A at 260 and 500 nm</li><li>≤0.00040A at 2A at 260 and 500 nm</li></ul></li><li><strong>Optical Design:</strong> Double Beam</li><li><strong>Photometric Accuracy:</strong> ±0.002A at 0.5A, ±0.004A at 1.0A, ±0.008 A at 2.0 A</li><li><strong>Photometric Display:</strong> -3A to +5A</li><li><strong>Photometric Range:</strong> –2A to +3.5A</li><li><strong>Photometric Repeatability:</strong> ±0.001 A at 1 A measured at 1.0 A at 546 nm</li><li><strong>Printer Included:</strong> Snap-on printer available</li><li><strong>Scan Speed:</strong> Slow, medium and fast – up to 1600 nm/min.</li><li><strong>Stray Light:</strong> &lt; 1.0%T 198 nm (KCl) , &lt;0.05%T at 220 nm (NaI), &lt;0.03%T at 340 nm (NaNO<sub>2</sub>)</li><li><strong>Warranty:</strong> 2 yrs std + 1 yr ext upon reg</li><li><strong>Wavelength Accuracy:</strong> ±0.5 nm</li><li><strong>Wavelength Data Interval:</strong> 0.1 nm, 0.2 nm, 0.5 nm, 1 nm, 2 nm, 5 nm</li><li><strong>Wavelength Repeatability:</strong> &lt; ±0.2 nm</li><li><strong>Weight (Metric):</strong> 7.5 kg</li><li><strong>Detector Type:</strong> Dual Silicon Photodiodes</li><li><strong>Display:</strong> 7 in. High Definition Color Touchscreen, Tiltable, 800 x 1280 pixels</li><li><strong>Spectral Bandwidth:</strong> 2 nm</li><li><strong>Type:</strong> UV-Vis Spectrophotometer</li><li><strong>Wavelength Range:</strong> 190 to 1100 nm</li><li><strong>Unit Size:</strong> Each</li></ul>

Thermo Scientific BioMate 160 UV-Vis Spectrophotometer

Perform quantitative measurements in life science laboratories with the automated and network-capable Thermo Scientific™ BioMate™ 160 UV-Visible Spectrophotometer. 

<p><strong>Perform quantitative measurements in life science laboratories with the automated and network-capable Thermo Scientific™ BioMate™ 160 UV-Visible Spectrophotometer. The BioMate 160 Spectrophotometer offers pre-programmed assay methods for nucleic acid and protein concentration as well as cell culture measurements. Optimized for usability and performance, this platform features a high-resolution color touchscreen, optional Wi-Fi networking, and a rugged design.</strong></p><p>The BioMate UV-Vis Spectrophotometer provides automation for high-throughput options and room-light resistance, allowing lid-open operation for improved speed and convenience. Software includes pre-programmed life science methods such as Nucleic Acid A260; Protein A280 and A205; Protein Colorimetric assays and OD600.</p><p>A full line of accessories, including automated cell changers and cell holders, sipper, and fiber optic probes are designed to simplify sampling and accommodate high throughput measurements and temperature control.</p><h5><strong>Features:</strong></h5><ul><li>7-inch high-resolution touchscreen user interface</li><li>Pre-programmed life science methods</li><li>Networking capable (Wi-Fi adaptor available)</li><li>Room light resistance for 'open-lid' operation</li><li>Sipper accessory</li><li>Removable, washable sample compartment liner with magnetic placement and hold-down</li><li>Accommodates cells up to 100 mm pathlength</li><li>(Optional) 8-position cell changer with switchable turret</li><li>(Optional) 4-position cell changer (long path cells)</li><li>(Optional) Peltier-thermostatted single cell holder (20 °C - 60 °C)</li></ul><h5><strong>Designed for:</strong></h5><ul><li>Advanced teaching labs</li><li>R&amp;D departments</li><li>Applications requiring high throughput or temperature control</li></ul><h4><strong>Specifications</strong></h4><p><strong>Instrument Type:</strong> UV-Visible Spectrophotometer<br><strong>Optical Design:</strong> Dual beam<br><strong>Wavelength Range:</strong> 190–1100 nm<br><strong>Spectral Bandwidth:</strong> 2 nm<br><strong>Photometric Range:</strong> –2 A to +3.5 A<br><strong>Photometric Accuracy:</strong> ±0.002 A at 0.5 A, ±0.004 A at 1.0 A, ±0.008 A at 2.0 A<br><strong>Photometric Repeatability:</strong> ±0.001 A at 1 A (546 nm)<br><strong>Photometric Display:</strong> –3 A to +5 A<br><strong>Noise (RMS at 500 nm):</strong></p><ul><li>≤0.00020 A at 0 A</li><li>≤0.00030 A at 1 A</li><li>≤0.00040 A at 2 A<br><strong>Drift:</strong> &lt;0.0005 A/hr at 500 nm after 1-hour warmup<br><strong>Baseline Flatness:</strong> ±0.002 A<br><strong>Stray Light:</strong></li><li>&lt;1.0%T at 198 nm (KCl)</li><li>&lt;0.05%T at 220 nm (NaI)</li><li>&lt;0.03%T at 340 nm (NaNO₂)</li></ul><h5><strong>Wavelength Performance</strong></h5><ul><li><strong>Accuracy:</strong> ±0.5 nm</li><li><strong>Repeatability:</strong> ±0.2 nm</li><li><strong>Data Interval Options:</strong> 0.2, 0.5, 1, 2, 5 nm</li><li><strong>Scan Speed:</strong> Slow, medium, fast (up to 1600 nm/min)</li></ul><h5><strong>Display &amp; User Interface</strong></h5><ul><li><strong>Touchscreen:</strong> 7 in. high-definition color, tiltable (800 × 1280 px)</li><li><strong>Keypad:</strong> Touchscreen interface</li></ul><h5><strong>Connectivity &amp; Data Handling</strong></h5><ul><li><strong>Connections:</strong> Single USB-A, Duplex USB-A</li><li><strong>Data Export:</strong> USB, Ethernet, Wi-Fi adaptor (optional)</li><li><strong>Printer Support:</strong> Snap-on printer (optional), USB/Ethernet/Wi-Fi printing available</li></ul><h5><strong>Sample Compartment Compatibility (Optional Accessories)</strong></h5><ul><li>8-position or 4-position cell changers</li><li>Long path cell changer</li><li>Peltier thermostatted cell holder (20–60 °C)</li><li>Sipper accessory</li><li>Fiber optic probe coupler</li></ul><h5><strong>General Specifications</strong></h5><ul><li><strong>Lamp Life:</strong> &gt;5 years typical, 3 years guaranteed</li><li><strong>Detector Type:</strong> Dual silicon photodiodes</li><li><strong>Dimensions (L × W × H):</strong> 35.5 × 38.5 × 19.5 cm</li><li><strong>Weight:</strong> 7.5 kg</li><li><strong>Power Requirements:</strong> 100–240 V, 50/60 Hz (auto-selecting via external AC–DC converter)</li><li><strong>Certifications:</strong> Certificate of Analysis (COA), Certificate of Conformance (COC)</li><li><strong>Warranty:</strong> 2 years standard + 1-year extension upon registration</li><li><strong>Unit Size:</strong> Each</li></ul>

Thermo Scientific EXTREVA ASE Accelerated Solvent Extractor

Achieve true walkaway sample-to-vial sample preparation with the Thermo Scientific™ EXTREVA™ ASE™ Accelerated Solvent Extractor. 

<p><strong>Achieve true walkaway sample-to-vial sample preparation with the Thermo Scientific™ EXTREVA™ ASE™ Accelerated Solvent Extractor. Without any intervention, perform sample extraction, in-cell cleanup and evaporation—all in one seamless operation—reducing manual labor from hours to minutes and enabling you to focus on other lab priorities while using up to 50% less solvent than other sample preparation techniques.</strong></p><p><strong>Accelerate your journey from sample to vial</strong></p><h5><strong>The EXTREVA ASE Accelerated Solvent Extractor offers:</strong></h5><ul><li><strong>All-in-one sample preparation.</strong> The EXTREVA ASE system automatically extracts and concentrates samples, eliminating the need to manually move sample extracts to another device for solvent evaporation.</li><li><strong>A walk-away solution. </strong>The system minimizes hands-on sample preparation tasks, enabling staff to accomplish other tasks.</li><li><strong>Parallel extraction. </strong>One EXTREVA ASE system can perform four parallel sample extractions, substantially increasing throughput.</li><li><strong>Gas-assisted extraction. </strong>The dynamic gas-assisted extraction mode reduces solvent consumption to between 5 and 100 milliliters per sample in most cases.</li><li><strong>Automation. </strong>Full automation improves recoveries and reproducibility while reducing training needs. Unlike humans, automated systems are ideal for performing the same tedious task repeatedly, and they don’t make mistakes.</li><li><strong>Method flexibility and optimization</strong>. Up to six different solvents can be used, including wash solvents for cleaning between methods. Precise flow control optimizes methods.</li><li><strong>Barcode-reading.</strong> The system tracks sample information and preparation parameters using a 2-D bar code reader to facilitate tracking and integrity. Data is recorded on the instrument or Thermo Scientific™ <a target="_blank" rel="noopener noreferrer" href="https://lcms.labrulez.com/products/76"><strong>Chromeleon™ Chromatography Data System (CDS) software</strong></a>.</li></ul><h4><strong>Specifications</strong></h4><ul><li><strong>Instrument Type:</strong> Automated Sample Preparation System</li><li><strong>Application:</strong> Simultaneous sample extraction and concentration</li><li><strong>Model Description:</strong> EXTREVA ASE Extraction and Evaporation System</li></ul><h5><strong>Performance &amp; Capabilities</strong></h5><ul><li><strong>Extraction Temperature Range:</strong> 40–200 °C</li><li><strong>Evaporation Temperature Range:</strong> 40–100 °C</li><li><strong>Compatible Solvents:</strong> Wide range of organic and aqueous solvents</li><li><strong>Pressure Capability:</strong> Up to 200 psi</li><li><strong>Power Consumption:</strong> 2000 W</li><li><strong>Frequency:</strong> 50/60 Hz</li></ul><h5><strong>Sample &amp; Solvent Handling</strong></h5><ul><li><strong>Extraction Cells (stainless steel):</strong> 1, 5, 10, 22, 34, 66, 100 mL</li><li><strong>Extraction Cell Tray:</strong> 16-position with 1 rinse</li><li><strong>Collection Vials:</strong><ul><li>60 mL and 100 mL evaporation vials</li><li>250 mL evaporation bottles</li><li>Direct concentrate to 2 mL sample vials with rinse capability</li></ul></li><li><strong>Collection Vial Tray:</strong> 16-position tray insert for 60 mL vials and 250 mL bottles; includes 4 rinse positions</li></ul><h5><strong>Utilities &amp; Requirements</strong></h5><ul><li><strong>Pneumatic Requirements:</strong><ul><li>Air: 130–140 psi</li><li>Nitrogen: 350–450 psi</li></ul></li></ul><h5><strong>Physical Specifications</strong></h5><ul><li><strong>Dimensions (D × W × H):</strong> 65.2 × 100 × 88.6 cm (25.6 × 39.4 × 34.8 in.)</li><li><strong>Weight:</strong> 160 kg (353 lb)</li><li><strong>Unit Size:</strong> Each</li></ul>

Thermo Scientific™ Dionex™ ASE™ 350 Accelerated Solvent Extractor

Save time, reduce solvent consumption, and boost productivity with Thermo Scientific™ Dionex™ ASE™ 350 Accelerated Solvent Extractor.

<div><p><strong>Automate extraction, filtration and clean up of compounds from solid and semisolid samples in minutes using the automated Thermo Scientific™ Dionex™ ASE™ 350 Accelerated Solvent Extractor. This system accommodates sample sizes of 1-100g, allows unattended extraction of up to 24 samples and uses 50 to 90% less solvent compared to other methods.&nbsp;</strong></p><p>The chemically inert pathway supports acid and alkaline sample matrices and solvents. Flexible, easy-to-operate and cost-effective, the Dionex ASE 350 is ideally suited for high-throughput laboratories and for a wide variety of applications.</p><div><h4><strong>Rapid and efficient extractions</strong></h4><ul><li>Elevated temperature (up to 200°C) and pressure (1500psi) reduce extraction times and solvent consumption</li><li>Fast pump (70mL/min.) enables fast extractions (typically 12-20 minutes)</li><li>Specialized oven design ensures precise temperature control for excellent reproducibility</li><li>Integrated solvent controller allows mixing and delivery of up to three solvents</li><li>The <strong>Thermo Scientific™ SmartRun™ System</strong> ensures cell size and collection vessel size are matched for an optimal extraction</li></ul><h4><strong>Enhanced flexibility to support multiple applications</strong></h4><ul><li>System accommodates <strong>1, 5, 10, 22, 34, 66 </strong>and <strong>100mL cell sizes</strong></li><li>pH-hardened pathway with <strong>Thermo Scientific™ Dionium™ components and cell</strong> enables compatibility with acid or alkaline pretreated matrices</li></ul><h4><strong>Dramatically reduced solvent consumption</strong></h4><ul><li>Requires less than 50mL solvent for a 20g sample</li><li>Includes solvent saver mode for further solvent savings</li></ul><h4><strong>Enhanced laboratory productivity</strong></h4><ul><li>System holds up to 24 samples for unattended operation</li><li>Flow-through technology allows in-line filtration and in-cell cleanup</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Dionex_ASE_350_system_2_9426ff3f9a/Thermo-Scientific-Dionex-ASE-350-system_2.jpg" alt="Thermo Scientific™ Dionex™ ASE™ 350 Accelerated Solvent Extractor" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Scientific_Dionex_ASE_350_system_2_9426ff3f9a/thumbnail_Thermo-Scientific-Dionex-ASE-350-system_2.jpg 114w," sizes="100vw" width="579" height="792"></p><h3><strong>🛠️ Specifications</strong></h3><ul><li><strong>Collection Vial Tray</strong>: 26-position tray insert for 60 mL vials; 19-position tray insert for 250 mL bottles</li><li><strong>Depth (English)</strong>: 27.3 in.</li><li><strong>Depth (Metric)</strong>: 69.3 cm</li><li><strong>Description</strong>: Extractor Only</li><li><strong>Extraction Fluids</strong>: Compatible with a wide range of organic and aqueous solvents</li><li><strong>Fluid Sensors</strong>: IR</li><li><strong>Frequency</strong>: 50/60 Hz</li><li><strong>Height (English)</strong>: 24.3 in.</li><li><strong>Height (Metric)</strong>: 61.7 cm</li><li><strong>Pneumatic Requirements</strong>: Air at 400–827 kPa (60–120 psi); N2 (at 1034 ×–1340 kPa (150–200 psi))</li><li><strong>Power Consumption</strong>: 500 Max VA</li><li><strong>Pressure</strong>: 10 MPa (1500 psi)</li><li><strong>Pump Flow</strong>: 70 mL/min</li><li><strong>Temperature Control</strong>: Up to 200 °C</li><li><strong>Weight (English)</strong>: 140 lb.</li><li><strong>Weight (Metric)</strong>: 65 kg</li><li><strong>Width (English)</strong>: 26.5 in.</li><li><strong>Width (Metric)</strong>: 67.3 cm</li><li><strong>Collection Vials</strong>: 60, 250 mL</li><li><strong>Dimensions (D x W x H)</strong>: 69.3 x 67.3 x 61.7 cm</li><li><strong>Extraction Cell Tray</strong>: 24 Cell, 2 Rinse</li><li><strong>Extraction Cells</strong>: 1, 5, 10, 22, 34, 66, 100 mL</li><li><strong>For Use With (Equipment)</strong>: Dionex ASE 350</li><li><strong>Type</strong>: Dionex ASE 350 System</li><li><strong>Unit Size</strong>: Each</li></ul></div></div>

Thermo Scientific Orbitrap Ascend Tribrid Mass Spectrometer

Be ready for tomorrow’s most challenging demands. Exceed experimental expectation with the MultiOmics, Structural Biology, and BioPharma Editions of the Thermo Scientific Orbitrap Ascend Editions Tribrid Mass Spectrometer.

<p><strong>Exceed experimental expectation with the MultiOmics, Structural Biology, and BioPharma Editions of the Thermo Scientific Orbitrap Ascend Editions Tribrid Mass Spectrometer.</strong></p><p><strong>With new capabilities for multiplexed quantitative proteomics, native protein characterization, and deep biopharmaceutical analyses, the three new Editions deliver ultimate experimental throughput, versatility, and ease-of-use for your specific needs.</strong></p><p>Detect and characterize the most difficult protein complexes and native samples without losing low <i>m/z</i> instrument performance and flexibility with the new Native MS option, including world class Orbitrap detection up to <i>m/z</i> 16,000 and ion isolation in the ion trap and quadrupole up to <i>m/z</i> 8,000, with isolation widths down to <i>m/z</i> 100 and <i>m/z</i> 5, respectively.</p><figure class="image"><img style="aspect-ratio:1937/796;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Scientific_Orbitrap_Ascend_Tribrid_hmotnostni_spektrometr_3_03576fcf9a/Thermo-Scientific-Orbitrap-Ascend-Tribrid-hmotnostni-spektrometr_3.jpg" alt="Thermo Fisher Scientific: Key innovations for Thermo Scientific Orbitrap Ascend Tribrid Mass Spectrometer" width="1937" height="796"></figure><h3><strong>Orbitrap Ascend Editions Tribrid MS</strong></h3><div><ul><li><strong>Orbitrap Ascend MultiOmics Tribrid MS: </strong>Discover more from comprehensive metabolomics to proteomics.</li><li><strong>Orbitrap Ascend Structural Biology Tribrid MS:</strong> Take advantage of ultimate versatility for native protein characterization.</li><li><strong>Orbitrap Ascend BioPharma Tribrid MS: </strong>Successfully characterize your most complex biotherapeutics.</li></ul><div><h3><strong>Introducing the Orbitrap Ascend Editions Tribrid MS</strong></h3></div><div><div><div id="container-deb530bb93"><div><div><div id="container-fffbeb2334"><div><div><div id="text-1451003751"><p>Eliminate the guesswork from your purchase decision with the MultiOmics, BioPharma, and Structural Biology Editions of the Thermo Scientific Orbitrap Ascend Tribrid Mass Spectrometer.&nbsp;Simplify your decisions and streamline your research with a tailored configuration for your unique application space.</p><p>Employ cutting edge native structural and biopharmaceutical analyses with multiple fragmentation and ion manipulation techniques. With the new Native MS option, detect protein complexes up to <i>m/z</i> 16,000 in the Orbitrap mass analyzer and isolate proteoforms&nbsp;up to <i>m/z</i> 8,000 with an isolation width as low as <i>m/z</i> 5 in the quadrupole.</p><p>Quantify more peptides, identify more proteins, confidently assign more labile-PTMs, and discover more previously undetectable protein complexes. Characterize proteoforms and modified compounds with more precision than ever before.&nbsp;</p></div></div></div></div></div></div></div></div></div><h3><strong>System highlights</strong></h3><h5><strong>Spend less time on instrument set-up and focus on your science</strong></h5><p>With the integrated Auto-Ready ion source, trigger on-demand or scheduled system calibrations remotely and without disruption to your LC-MS system.</p><h5><strong>Gain increased characterization from lipids to intact proteins to oligonucleotides with orthogonal fragmentation &nbsp;</strong></h5><p>The Orbitrap Ascend Editions mass spectrometers have multiple fragmentation techniques that provide complementary information.</p><ul><li>Standard collision-induced dissociation (CID) and higher-energy collisional dissociation (HCD) can be used for multiple analytes.</li><li>Optional electron transfer dissociation (ETD) increases coverage for proteins and glycopeptide experiments, and ultraviolet photodissociation (UVPD) benefits protein, oligonucleotide, and lipid analysis.</li></ul><h5><strong>Study the largest protein complexes using native MS techniques, all on the same system as bottom-up proteomics techniques</strong></h5><p>The Native MS option comprises the extension of the Orbitrap mass range to m/z 16,000, ion trap ion isolation up to 8,000 with MSn capabilities, and more sensitive and selective extended quadrupole isolation up to m/z 8,000. With the Native MS option, you can detect large protein complexes and characterize the subunits by multiple fragmentation techniques.</p><h5><strong>Environmentally friendly dry pumps decrease energy usage and maintenance</strong></h5><p>By changing the fore pumps from oil-based to a dry pump, we reduce the heat output by 22%. They also eliminate the production of oil vapors and the need for oil checks and changes, lowering maintenance.</p><p>The Orbitrap Ascend Editions mass spectrometers have also received the ACT label, the standard for determining the environmental impact of laboratory products to help labs make informed, sustainable purchasing decisions.</p><h5><strong>Software solutions for your application</strong></h5><p>Streamlined instrument control software across all next-generation Thermo Scientific platforms for ease-of-use through different systems. Edition-specific application templates are ready to use and built into the method editor so you can get meaningful results faster.</p><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Thermo_Scientific_Orbitrap_Ascend_Tribrid_Mass_Spectrometer_The_most_versatile_platform_for_deep_untargeted_and_accurate_targeted_metabolomics_336c0b833d.jpg" alt="Thermo Fisher Scientific: Thermo Scientific Orbitrap Ascend Tribrid Mass Spectrometer - The most versatile platform for deep untargeted and accurate targeted metabolomics" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Thermo_Scientific_Orbitrap_Ascend_Tribrid_Mass_Spectrometer_The_most_versatile_platform_for_deep_untargeted_and_accurate_targeted_metabolomics_336c0b833d.jpg 245w," sizes="100vw" width="2349" height="1165"></p><h4><strong>Orbitrap Ascend MultiOmics Tribrid MS</strong></h4><p>Benefit from experimental throughput, versatility, and ease-of-use. With industry leading capabilities, the Thermo Scientific Orbitrap Ascend MultiOmics Tribrid Mass Spectrometer delivers ultimate data quality. Quantify more samples at lower concentrations using intelligent acquisition and faster Real-Time Search.</p><h5><strong>Applications</strong></h5><ul><li>The most versatile platform for deep untargeted and accurate targeted metabolomics</li><li>The most versatile platform for deep untargeted and accurate targeted metabolomics</li><li>The most versatile platform for deep untargeted and accurate targeted metabolomics</li><li>The most versatile platform for deep untargeted and accurate targeted metabolomics</li><li>The most versatile platform for deep untargeted and accurate targeted metabolomics</li><li>Lipidomics experiments benefit from AqcuireX software and alternative fragmentation capabilities</li></ul><h4><strong>Orbitrap Ascend Structural Biology Tribrid MS</strong></h4><div><div id="container-26e6c6fa34"><div><div><div id="text-872767366"><p>Be prepared for tomorrow's challenges in structural analysis with this powerful solution. Achieve greater coverage and explore different ion manipulation options with an expanded <i>m/z</i> range and multiple fragmentation options.</p><ul><li>Characterize complex molecules (Native MS option) with a recommended mass range up to <i>m/z</i> 16,000 and an extended quadrupole isolation range of up to <i>m/z</i> 8,000.</li><li>Take advantage of multiple fragmentation options (ETD, EThcD, UVPD) and Proton-Transfer Charge Reduction to achieve comprehensive sequence coverage of your protein target.</li></ul><h5><strong>Applications</strong></h5><ul><li>Native MS option facilitates the identification of membrane proteins by top-down MS&nbsp;</li><li>Utilizing PTCR for complex mixture analysis enables more identification across the <i>m/z</i> range &nbsp;</li><li>Crosslinking experimentation is aided by Real-Time Library Search available on the Orbitrap Ascend Structural Biology MS&nbsp;&nbsp;</li><li>Comprehensive disulfide bond mapping analysis using FAIMS and EThcD</li><li>Characterize larger proteoforms by top-down proteomics</li><li>Characterize larger proteoforms by top-down proteomics</li><li>Native MS option extends ion detection of large protein complexes</li></ul><p><img src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Thermo_Fisher_Scientific_Thermo_Scientific_Orbitrap_Ascend_Tribrid_Mass_Spectrometer_Lipidomics_experiments_benefit_from_Aqcuire_X_software_and_alternative_fragmentation_capabilities_da54862143.jpg" alt="Thermo Fisher Scientific: Thermo Scientific Orbitrap Ascend Tribrid Mass Spectrometer - Lipidomics experiments benefit from AqcuireX software and alternative fragmentation capabilities" srcset="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/thumbnail_Thermo_Fisher_Scientific_Thermo_Scientific_Orbitrap_Ascend_Tribrid_Mass_Spectrometer_Lipidomics_experiments_benefit_from_Aqcuire_X_software_and_alternative_fragmentation_capabilities_da54862143.jpg 245w," sizes="100vw" width="3257" height="850"></p><h4><strong>Orbitrap Ascend BioPharma Tribrid MS</strong></h4></div></div></div></div></div><p>Elevate your analytical capabilities and successfully characterize your most complex products from peptides to native protein characterization with the Thermo Scientific Orbitrap Ascend BioPharma Tribrid Mass Spectrometer.&nbsp; Achieve greater coverage for oligonucleotide sequences and analyze even the largest and most complex molecules.</p><ul><li>Recommended alternate fragmentation techniques enable detailed structural elucidation.</li><li>Automated Auto-Ready ion source and application-specific pre-built method templates streamline instrument setup.</li></ul><h5><strong>Applications</strong></h5><ul><li>Comprehensive native analysis of complex therapeutic proteins using Native MS option and PTCR</li><li>Comprehensively characterize antibody-drug conjugates combining orthogonal fragmentation techniques</li><li>Enhanced speed and sensitivity for high sequence coverage and low abundant PTM identifications in peptide mapping experiments</li><li>Improved sensitivity allows highly confident identification of ppb Host Cell Proteins at analytical flow rates</li><li>Characterize intact sgRNA up to 100 base pairs using low-q CID fragmentation</li><li>Unparalleled characterization of low-abundant modifications in oligonucleotides</li></ul><p>&nbsp;</p></div>

Thermo Scientific Orbitrap Astral Mass Spectrometer

A new horizon for single-cell, quantitative, and translational proteomics.

<div><div container-id="cq-colctrl-lt1" comp-id="A1"><div><p><strong>Looking to unlock additional insights into biology and disease mechanisms? With faster throughput, deeper coverage, higher sensitivity, and accurate and precise quantitation; the Thermo Scientific Orbitrap Astral Mass Spectrometer enables you to dramatically expand the scale and scope of your experiments.</strong></p><p>See how it sets a new standard for mass spectrometry performance and redefines what is possible for discovery and translational research to help you rapidly and comprehensively capture the dynamic, temporal, and spatial complexity of biology.</p><h3><strong>Key benefits</strong></h3><h4><strong>Faster throughput</strong></h4><p>Achieve faster throughput with a high throughput injection-to-injection cycle of just 8 minutes.</p><ul><li>Analyze one sample in only 8 minutes</li><li>In one day, analyze over 1.4 million protein groups from 180 samples</li></ul><h4><strong>Deeper coverage</strong></h4><p>The near whole-proteome coverage of these methods reduces the chances of missing out on important proteins of interest.</p><ul><li>See more in less time or spend more time and go even deeper</li><li>Double the depth and quadruple the throughput for phosphoproteomics</li></ul><h4><strong>Higher sensitivity</strong></h4><p>The high dynamic range of the proteome necessitates the measurement of not only high abundance proteins, but also proteins with just a few copies.</p><ul><li>Deeper coverage from single cells at faster throughput</li><li>1 ng HeLa DIA/18 min (80 SPD)</li></ul><h4><strong>Accurate and precise quantitation</strong></h4><p>Biological changes are quantitative in nature, requiring accurate and precise measurements to determine statistically significant biomarkers.</p><ul><li>Accurate and precise quantitation of three-proteome mixtures</li><li>The Orbitrap Astral mass spectrometer enables accurate and precise quantitation with 88% of identified proteins having 20% CV or less and 75% having 10% CV or less</li></ul><p><img style="aspect-ratio:1224/513;" src="https://storage.googleapis.com/labrulez-bucket-strapi-h3hsga3/Pragolab_Konstrukce_hmotnostniho_spektrometru_Thermo_Orbitrap_Astral_e38e10580c/Pragolab-Konstrukce-hmotnostniho-spektrometru-Thermo-Orbitrap-Astral.jpg" alt="Thermo Fisher Scientific: Thermo Scientific Orbitrap Astral Mass Spectrometer" width="1224" height="513"></p><h3><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-astral-mass-spectrometer.html"><strong>An overview</strong></a><strong> of the Orbitrap Astral MS from Alexander Makarov, Ph.D.</strong></h3><p>The new Astral analyzer builds on Thermo Fisher Scientific’s proven Orbitrap mass spectrometry platform with novel technology to deliver up to two times deeper proteome coverage and up to four times more throughput compared to current mass spectrometers.</p><p>Alexander Makarov, Ph.D., Director Global Research LSMS, Thermo Fisher Scientific, claims the Astral analyzer represents a new class of high-resolution accurate-mass analyzers with a unique performance envelope.</p><p>"The introduction of the Astral analyzer represents a starting point in the future evolution of its technology to new frontiers of performance," said Makarov.</p><h3><strong>What customers are saying</strong></h3><h4><strong>A New Standard for Data-Independent Acquisition</strong></h4><p>Learn how the Orbitrap Astral mass spectrometer will enable precision medicine at scale with revolutionary new DIA methods for plasma proteomics.</p><p>The future of proteomics lies in the accurate and precise measurement of thousands of proteins across thousands of samples. Data-independent Acquisition (DIA) facilitates deep proteome coverage with high quantitative accuracy and precision using label-free quantitation (LFQ) due to the unbiased and reproducible nature of mass spectrometry measurements.</p><div><div container-id="cq-colctrl-lt0" comp-id="A1"><div><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-astral-mass-spectrometer/why-orbitrap-astral.html?videoId=6331001711112">Mike MacCoss, Ph.D.</a>, Professor, Department of Genome Sciences, University of Washington</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-astral-mass-spectrometer/why-orbitrap-astral.html?videoId=6331014977112">Jennifer Van Eyk, Ph.D.</a>, Director, Basic Science Research, Barbra Streisand Women’s Heart Center Director, Advanced Clinical Biosystem Institute Center, Cedars-Sinai</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-astral-mass-spectrometer/why-orbitrap-astral.html?videoId=6331000425112">Jesper Olsen, Ph.D.</a>, Deputy Center Director, Professor, Novo Nordisk Foundation Center for Protein Research, University of Copenhagen</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-astral-mass-spectrometer/why-orbitrap-astral.html?videoId=6331001022112">Qing Yu</a>, Research Associate at Harvard Medical School</li></ul></div></div></div><h4><strong>The Era of Single-Cell Proteomics Has Arrived</strong></h4><p>Single cell proteomics can determine the dynamic nature of the proteome across cell types in both time and space. The increased resolution that is gained by measuring single cells instead of bulk samples provides a deeper insight into disease mechanisms and fundamental biological processes to unravel the complexity of biology. Learn how the Orbitrap Astral mass spectrometer opens a new horizon for single-cell proteomics by empowering higher throughput and deeper coverage without sacrificing quantitative accuracy and precision.</p><div><div container-id="cq-colctrl-lt0" comp-id="B1"><div><ul><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-astral-mass-spectrometer/why-orbitrap-astral.html?videoId=6331010858112">Erwin Schoof, Ph.D.</a>, Associate Professor, Department of Biotechnology and Biomedicine, Section for Protein Science and Biotherapeutics, Cell Diversity Lab, Technical University of Denmark</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-astral-mass-spectrometer/why-orbitrap-astral.html?videoId=6331001916112">Joshua Coon, Ph.D.</a>, Professor of Biomolecular Chemistry at the University of Wisconsin-Madison</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-astral-mass-spectrometer/why-orbitrap-astral.html?videoId=6331012816112">Nikolai Slavov, Ph.D.</a>, Founding Director of Parallel Squared Technology Institute and Professor at Northeastern University</li><li><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/industrial/mass-spectrometry/liquid-chromatography-mass-spectrometry-lc-ms/lc-ms-systems/orbitrap-lc-ms/orbitrap-astral-mass-spectrometer/why-orbitrap-astral.html?videoId=6331016836112">Sophia Steigerwald, Ph.D.</a>, Student at the Max Planck Institute of Biochemistry</li></ul></div></div></div><h3><strong>How it works</strong></h3><p>The Orbitrap Astral Mass Spectrometer combines three mass analyzers: a quadrupole mass analyzer for high selectivity and high ion transmission; an Orbitrap mass analyzer for high dynamic range and high-resolution measurements; and a novel Astral analyzer for fast and sensitive measurements. The front end, from the ion source up to the segmented quadrupole mass filter, is designed to maximize instrument sensitivity and robustness. Ions are trapped and concentrated in the ion routing multipole, which facilitates the transfer of ions to either of the high-resolution accurate-mass (HRAM) analyzers. Synchronization of ion transfer and processing throughout the instrument enables the parallel handling of five separate ion packets simultaneously. This synchronization enables each mass analyzer to be used in combination to optimize performance and experimental flexibility.</p><p>The Orbitrap analyzer is ideally suited for the acquisition of high dynamic range HRAM MS and MS<sup>2</sup> spectra, including an optional Biopharma mode to extend the mass range up to <i>m/z</i> 8,000. The Astral Mass Analyzer delivers high acquisition rates up to 200 Hz, single ion detection sensitivity, and high dynamic range HRAM SIM and MS<sup>2</sup> measurements that are fully synchronized with parallel Orbitrap analyzer operation. Due to this synchronization the Orbitrap Astral Mass Spectrometer excels at many data acquisition strategies including High Resolution Data-Independent Acquisition (HR-DIA) and data-dependent acquisition (DDA). These acquisition strategies combined with the high resolution and dynamic range of the Orbitrap and Astral analyzers enable accurate and precise quantitation using either Label-Free Quantitation (LFQ) or multiplexing with Tandem Mass Tag (TMT)-labeled peptides.</p></div></div></div><p class="cke-user_style-important"><strong>A 3D tour of the instrument can be found </strong><a target="_blank" rel="noopener noreferrer" href="https://www.thermofisher.com/cz/en/home/virtual/orbitrap-astral-ms-3d-tour.html"><strong>here</strong></a><strong>.</strong></p>

Products distributed by Thermo Fisher Scientific (EMEA) - page 14

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